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Found 3339 Enz. Inhib. hit(s) with Target = 'C-C chemokine receptor type 5'
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50267124(CHEMBL2163486)
Affinity DataKd:  1.60nMAssay Description:Antagonist activity at human CCR5 expressed in HEK 293 Glosensor cells assessed as reduction in RANTES-induced intracellular calcium levels preincuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50336345(4-(4-(((R)-1-butyl-3-((R)-cyclohexyl(hydroxy)methy...)
Affinity DataKd:  3nMAssay Description:Binding affinity to CCR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50339033(5-[(4-(3S)-4-[(1R,2R)-2-ethoxy-5-(trifluoromethyl)...)
Affinity DataKd:  3.10nMAssay Description:Activation of CCR5 in human PBMC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50267125(CHEMBL4089991)
Affinity DataKd:  10nMAssay Description:Antagonist activity at human CCR5 expressed in HEK 293 Glosensor cells assessed as reduction in RANTES-induced intracellular calcium levels preincuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Mus musculus)
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50000788((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...)
Affinity DataKd:  11nMAssay Description:Binding affinity to CCR5 in NY1DD transgenic mouse brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Mus musculus)
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50000788((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...)
Affinity DataKd:  21nMAssay Description:Binding affinity to CCR5 in C57BL/6J mouse brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50509860(CHEMBL4442783)
Affinity DataKd:  24nMAssay Description:Binding affinity to CCR5 in T-cell (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50334986(4,4-Difluoro-cyclohexanecarboxylic acid {(S)-3-[(1...)
Affinity DataKd:  25nMAssay Description:Binding affinity to CCR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50267126(CHEMBL4068906)
Affinity DataKd:  316nMAssay Description:Antagonist activity at human CCR5 expressed in HEK 293 Glosensor cells assessed as reduction in RANTES-induced intracellular calcium levels preincuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50378981(CHEMBL2011439)
Affinity DataKd:  8.20E+3nMAssay Description:Binding affinity to C-terminus C9-tagged immobilized CCR5 by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50378980(CHEMBL1618631)
Affinity DataKd:  1.00E+4nMAssay Description:Binding affinity to C-terminus C9-tagged immobilized CCR5 by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50378978(CHEMBL2011440)
Affinity DataKd:  1.08E+4nMAssay Description:Binding affinity to C-terminus C9-tagged immobilized CCR5 after 1 min by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50378978(CHEMBL2011440)
Affinity DataKd:  1.75E+4nMAssay Description:Binding affinity to C-terminus C9-tagged immobilized CCR5 by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50378983(CHEMBL1907216)
Affinity DataKd:  1.84E+4nMAssay Description:Binding affinity to C-terminus C9-tagged immobilized CCR5 by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50378979(CHEMBL2011441)
Affinity DataKd:  2.26E+4nMAssay Description:Binding affinity to C-terminus C9-tagged immobilized CCR5 by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50378982(CHEMBL1623307)
Affinity DataKd:  2.75E+4nMAssay Description:Binding affinity to C-terminus C9-tagged immobilized CCR5 by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50378979(CHEMBL2011441)
Affinity DataKd:  2.86E+4nMAssay Description:Binding affinity to C-terminus C9-tagged immobilized CCR5 after 1 min by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50378977(CHEMBL1621896)
Affinity DataKd:  4.90E+4nMAssay Description:Binding affinity to C-terminus C9-tagged immobilized CCR5 by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50134046((4-{(4-Bromo-phenyl)-[(E)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Macaca fascicularis)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50334986(4,4-Difluoro-cyclohexanecarboxylic acid {(S)-3-[(1...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [125I]-MIP-1alpha from CCR5 in rhesus monkey Chem-1 cell membranes after 120 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Macaca fascicularis)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50464147(CHEMBL256907)
Affinity DataKi:  0.240nMAssay Description:Displacement of [125I]MIP-1alpha from CCR5 receptor in rhesus monkey membrane incubated for 120 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM160935(US10167299, Maraviroc | US9107954, maraviroc)
Affinity DataKi:  0.240nMAssay Description:Afterwards, the pharmacological profile of bivalent ligand 1 at the chemokine receptor CCR5 was characterized similarly. The competitive radioligand ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50124943((4-{(4-Bromo-phenyl)-[(Z)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of [125I]RANTES binding to CCR5 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50134054((4-{(4-Bromo-phenyl)-[(E)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50124953((4-{(4-Bromo-phenyl)-[(Z)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of [125I]RANTES binding to CCR5 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50134070((4-{(4-Bromo-phenyl)-[(E)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50124957((4-{(4-Bromo-phenyl)-[(Z)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of [125I]RANTES binding to CCR5 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50123438((3,5-Dichloro-pyridin-4-yl)-(4-methyl-4-{(S)-3-met...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50123438((3,5-Dichloro-pyridin-4-yl)-(4-methyl-4-{(S)-3-met...)
Affinity DataKi:  0.700nMAssay Description:Ability to inhibit [125I]-labeled RANTES binding to the CCR5 receptor expressed in membrane preparations from CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50124957((4-{(4-Bromo-phenyl)-[(Z)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50104942((4-Fluoro-naphthalen-1-yl)-{4-[4-(4-methoxy-benzen...)
Affinity DataKi:  1nMAssay Description:Inhibition of RANTES binding to C-C chemokine receptor type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50398339(CHEMBL2178569)
Affinity DataKi:  1nMAssay Description:Binding affinity to CCR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50104954((2,6-Dimethyl-phenyl)-(4-methyl-4-{(S)-3-methyl-4-...)
Affinity DataKi:  1nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50134072((4-{(4-Bromo-phenyl)-[(E)-methoxyimino]-methyl}-4'...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Mus musculus)
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50104933(CHEMBL105821 | {4-[(4-Bromo-phenyl)-ethoxyimino-me...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of RANTES binding to Chemokine receptor type 5 receptor from NIH 3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50145684((4,6-Dimethyl-pyrimidin-5-yl)-(4-methyl-4-{(S)-3-m...)
Affinity DataKi:  1.10nMAssay Description:Antagonistic activity of the compound against C-C chemokine receptor type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50104933(CHEMBL105821 | {4-[(4-Bromo-phenyl)-ethoxyimino-me...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of RANTES binding to C-C chemokine receptor type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50104940(CHEMBL323172 | {4-[(4-Bromo-phenyl)-methoxyimino-m...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of RANTES binding to C-C chemokine receptor type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50134044((4-{(4-Bromo-phenyl)-[(E)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Mus musculus)
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50104940(CHEMBL323172 | {4-[(4-Bromo-phenyl)-methoxyimino-m...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of RANTES binding to Chemokine receptor type 5 receptor from NIH 3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50124946((4-{(4-Bromo-phenyl)-[(Z)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of [125I]RANTES binding to CCR5 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50124946((4-{(4-Bromo-phenyl)-[(Z)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50124956((4-{(4-Bromo-phenyl)-[(E)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50124956((4-{(4-Bromo-phenyl)-[(E)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of [125I]RANTES binding to CCR5 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50145681((4,6-Dimethyl-pyrimidin-5-yl)-(4-methyl-4-{(S)-3-m...)
Affinity DataKi:  1.40nMAssay Description:Antagonistic activity of the compound against C-C chemokine receptor type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)
Affinity DataKi:  1.40nMAssay Description:Inhibitory activity of the compound against specific binding of [125I]-MIP-1 alpha to human CCR5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50145686((4-{(S)-4-[(S)-2-Cyclopropyl-1-(4-trifluoromethyl-...)
Affinity DataKi:  1.60nMAssay Description:Antagonistic activity of the compound against C-C chemokine receptor type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50115528((Z)-(4-((4-bromophenyl)(ethoxyimino)methyl)-4'-met...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of RANTES binding to C-C chemokine receptor type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50104946((2,4-Dimethyl-pyridin-3-yl)-(4-methyl-4-{(S)-3-met...)
Affinity DataKi:  2nMAssay Description:Ability to inhibit [125I]-labeled RANTES binding to the CCR5 receptor expressed in membrane preparations from CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50104930((Z)-{4-[(4-Bromo-phenyl)-methoxyimino-methyl]-[1,4...)
Affinity DataKi:  2nMAssay Description:Inhibition of RANTES binding to C-C chemokine receptor type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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