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Found 18 Enz. Inhib. hit(s) with Target = 'GABA A receptor alpha-1/beta-1/gamma-2'
TargetGABA A receptor alpha-1/beta-1/gamma-2(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50229594(CHEMBL253597 | N-(2-methoxybenzyl)-N-(4-phenoxypyr...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to GABA alpha-1-beta-1-gamma-2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50580362(CHEMBL5086854)
Affinity DataIC50:  1.50E+3nMAssay Description:Negative allosteric modulation activity at human GABAA alpha1beta1gamma2 stably expressed in HEK cells by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50064420((4-Hydroxy-3,5-diisopropyl-phenyl)-phenyl-methanon...)
Affinity DataEC50:  4.70E+4nMAssay Description:Direct activation of chloride current in Xenopus laevis oocytes expressing human alpha-1beta1-gamma2 GABA-A receptor subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50064419(4-Chloro-2,6-diisopropyl-phenol | CHEMBL292402)
Affinity DataEC50:  1.00E+4nMAssay Description:Modulation of GABA-induced chloride currents in Xenopus laevis oocytes expressing human alpha-1beta1-gamma2 GABA-A receptor subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50064424(4-Iodo-2,6-diisopropyl-phenol | 4-Iodo-2,6-diisopr...)
Affinity DataEC50:  1.20E+4nMAssay Description:Modulation of GABA-induced chloride currents in Xenopus laevis oocytes expressing human alpha-1beta1-gamma2 GABA-A receptor subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50058046(CHEMBL526 | propofol)
Affinity DataEC50:  8.00E+3nMAssay Description:Modulation of GABA-induced chloride currents in Xenopus laevis oocytes expressing human alpha-1beta1-gamma2 GABA-A receptor subunitsMore data for this Ligand-Target Pair
TargetGABA A receptor alpha-1/beta-1/gamma-2(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50064417(4-Bromo-2,6-diisopropyl-phenol | CHEMBL54497)
Affinity DataEC50:  1.20E+4nMAssay Description:Modulation of GABA-induced chloride currents in Xenopus laevis oocytes expressing human alpha-1beta1-gamma2 GABA-A receptor subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50064424(4-Iodo-2,6-diisopropyl-phenol | 4-Iodo-2,6-diisopr...)
Affinity DataEC50:  5.10E+4nMAssay Description:Direct activation of chloride current in Xenopus laevis oocytes expressing human alpha-1beta1-gamma2 GABA-A receptor subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50064420((4-Hydroxy-3,5-diisopropyl-phenyl)-phenyl-methanon...)
Affinity DataEC50:  9.00E+3nMAssay Description:Modulation of GABA-induced chloride currents in Xenopus laevis oocytes expressing human alpha-1beta1-gamma2 GABA-A receptor subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50064419(4-Chloro-2,6-diisopropyl-phenol | CHEMBL292402)
Affinity DataEC50:  3.80E+4nMAssay Description:Direct activation of chloride current in Xenopus laevis oocytes expressing human alpha-1beta1-gamma2 GABA-A receptor subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50459890(Bromophene | CHEBI:70620)
Affinity DataEC50:  320nMAssay Description:Agonist activity at recombinant human GABAA receptor alpha1beta1gamma2L expressed in Xenopus laevis oocytes incubated for 30 secs by electrophysiolog...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50503415(CHEMBL4540194)
Affinity DataEC50:  2.71E+5nMAssay Description:Positive allosteric modulation of GABA-A alpha1beta1gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GAB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50503414(CHEMBL4560044)
Affinity DataEC50:  9.80E+4nMAssay Description:Positive allosteric modulation of GABA-A alpha1beta1gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GAB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50503421(CHEMBL4587325)
Affinity DataEC50:  1.00E+4nMAssay Description:Positive allosteric modulation of GABA-A alpha1beta1(S290N)gamma2S mutant receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50503414(CHEMBL4560044)
Affinity DataEC50:  1.10E+4nMAssay Description:Positive allosteric modulation of GABA-A alpha1beta1(S290N)gamma2S mutant receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50503421(CHEMBL4587325)
Affinity DataEC50:  1.48E+5nMAssay Description:Positive allosteric modulation of GABA-A alpha1beta1gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GAB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50064417(4-Bromo-2,6-diisopropyl-phenol | CHEMBL54497)
Affinity DataEC50:  3.80E+4nMAssay Description:Direct activation of chloride current in Xenopus laevis oocytes expressing human alpha-1beta1-gamma2 GABA-A receptor subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50058046(CHEMBL526 | propofol)
Affinity DataEC50:  4.40E+4nMAssay Description:Direct activation of chloride current in Xenopus laevis oocytes expressing human alpha-1beta1-gamma2 GABA-A receptor subunitsMore data for this Ligand-Target Pair