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Found 1312 Enz. Inhib. hit(s) with Target = 'Heat shock protein HSP 90-beta'
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM50357454(CHEMBL1917878)
Affinity DataKd:  0.350nMAssay Description:Binding affinity to human Hsp90beta after overnight incubation by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM20926(5-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-N-ethyl-4-...)
Affinity DataKd:  1.70nMAssay Description:Binding affinity to Hsp90 nucleotide binding domainMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM20800(2-amino-6-halopurine analogue, 20 | 6-chloro-9-[(4...)
Affinity DataKd:  1.70nMAssay Description:Binding affinity to Hsp90 nucleotide binding domainMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM227589(Radicicol)
Affinity DataKd:  2.20nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM50492759(CHEMBL2413569)
Affinity DataKd:  2.80nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM50492753(CHEMBL2413570)
Affinity DataKd:  3.5nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM50492754(CHEMBL2413568)
Affinity DataKd:  3.60nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM15359((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Affinity DataKd:  7.30nMAssay Description:Binding affinity to human Hsp90beta after overnight incubation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM50492764(CHEMBL2413571)
Affinity DataKd:  10nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM225746(hsp90_43)
Affinity DataKd:  10.7nMAssay Description:ITCMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM50233854(CHEMBL267159 | Carbamic acid (4E,10E)-(8S,9S,12S,1...)
Affinity DataKd:  16nMAssay Description:Binding affinity to Hsp90 in human SKBR3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM225747(hsp90_44)
Affinity DataKd:  26.8nMAssay Description:ITCMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM50492762(CHEMBL2413565)
Affinity DataKd:  55nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM225719(hsp90_12)
Affinity DataKd:  68.6nMAssay Description:ITCMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM225744(hsp90_40)
Affinity DataKd:  69nMAssay Description:ITCMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM50492756(CHEMBL2413566)
Affinity DataKd:  72nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM50492755(CHEMBL2413587)
Affinity DataKd:  84nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM50492757(CHEMBL2413581)
Affinity DataKd:  89nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM50030868((8S,9S,12S,13R,14S,16R)-19-amino-13-hydroxy-8,14-d...)
Affinity DataKd:  100nMAssay Description:Binding affinity to human recombinant HSP90More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM50492758(CHEMBL2413580)
Affinity DataKd:  107nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM483525(US10927076, Compound KUNB22)
Affinity DataKd:  110nMAssay Description:Assay was performed in 96-well format in black, flat bottom plates (Santa Cruz Biotechnology) with a final volume of 100 μL. 25 μL of assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM225743(hsp90_38)
Affinity DataKd:  115nMAssay Description:ITCMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM225719(hsp90_12)
Affinity DataKd:  123nMAssay Description:Thermofluor AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM50492765(CHEMBL2413579)
Affinity DataKd:  151nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM50008059(CHEBI:5292 | GELDANAMYCIN)
Affinity DataKd:  152nMAssay Description:Binding affinity to N-terminal FLAG-tagged human recombinant HSP90beta expressed in Escherichia coli BL21(DE3) by microscale thermophoresis assayMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM50008059(CHEBI:5292 | GELDANAMYCIN)
Affinity DataKd:  158nMAssay Description:Binding affinity to recombinant human Hsp90 beta expressed in Escherichia coli BL21(DE3) pLysS by microscale thermophoresis assayMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM225744(hsp90_40)
Affinity DataKd:  165nMAssay Description:Thermofluor AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM225746(hsp90_43)
Affinity DataKd:  172nMAssay Description:Thermofluor AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM50526863(CHEMBL4474770)
Affinity DataKd:  180nMAssay Description:Binding affinity to HSP90-beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM483524(US10927076, Compound KUNB31a)
Affinity DataKd:  180nMAssay Description:Assay was performed in 96-well format in black, flat bottom plates (Santa Cruz Biotechnology) with a final volume of 100 μL. 25 μL of assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM50526863(CHEMBL4474770)
Affinity DataKd:  180nMAssay Description:Displacement of FITC-geldanamycin from HSP90beta (unknown origin) after 24 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM36528(3-benzyl-1-ethyl-6-methyl-1H,5H,6H,7H-pyrimido[5,4...)
Affinity DataKd:  182nMAssay Description:AlphaScreen technology based high-throughput (ALPHA) assay is used to identify inhibitors of Hsp90-TPR2A interaction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM50492760(CHEMBL2413586)
Affinity DataKd:  191nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM50492761(CHEMBL2413582)
Affinity DataKd:  201nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM34905(1,6-dimethyl-3-propyl-pyrimido[5,4-e][1,2,4]triazi...)
Affinity DataKd:  202nMpH: 8.0Assay Description:A fluorescence polarization (FP) assay monitor the fluorescein-labeled C-terminal Hsp90 peptide-TPRA interaction. FP assay will also confirm binding...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM225743(hsp90_38)
Affinity DataKd:  225nMAssay Description:Thermofluor AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM50492763(CHEMBL2413573)
Affinity DataKd:  237nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM483511(US10927076, Compound Table2.CHO)
Affinity DataKd:  240nMAssay Description:Assay was performed in 96-well format in black, flat bottom plates (Santa Cruz Biotechnology) with a final volume of 100 μL. 25 μL of assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM50161651(4-(1H-IMIDAZOL-4-YL)-3-(5-ETHYL-2,4-DIHYDROXY-PHEN...)
Affinity DataKd:  280nMAssay Description:Inhibition of Hsp90 by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM483530(US10927076, Compound KUNB28)
Affinity DataKd:  295nMAssay Description:Assay was performed in 96-well format in black, flat bottom plates (Santa Cruz Biotechnology) with a final volume of 100 μL. 25 μL of assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM31044(1-Ethyl-6-methyl-3-thiophen-2-yl-1H-pyrimido[5,4-e...)
Affinity DataKd:  308nMpH: 8.0Assay Description:A fluorescence polarization (FP) assay monitor the fluorescein-labeled C-terminal Hsp90 peptide-TPRA interaction. FP assay will also confirm binding...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM50249907((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-amino-8,13,14...)
Affinity DataKd:  320nMAssay Description:Binding affinity to human recombinant HSP90More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM483533(US10927076, Compound KUNB25)
Affinity DataKd:  330nMAssay Description:Assay was performed in 96-well format in black, flat bottom plates (Santa Cruz Biotechnology) with a final volume of 100 μL. 25 μL of assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM31040(1-Ethyl-6-methyl-3-phenyl-1H-pyrimido[5,4-e][1,2,4...)
Affinity DataKd:  360nMAssay Description:AlphaScreen technology based high-throughput (ALPHA) assay is used to identify inhibitors of Hsp90-TPR2A interaction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM31044(1-Ethyl-6-methyl-3-thiophen-2-yl-1H-pyrimido[5,4-e...)
Affinity DataKd:  365nMAssay Description:AlphaScreen technology based high-throughput (ALPHA) assay is used to identify inhibitors of Hsp90-TPR2A interaction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM34671(1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...)
Affinity DataKd:  365nMpH: 8.0Assay Description:A fluorescence polarization (FP) assay monitor the fluorescein-labeled C-terminal Hsp90 peptide-TPRA interaction. FP assay will also confirm binding...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM483515(US10927076, Compound Table2.CONH2)
Affinity DataKd:  370nMAssay Description:Assay was performed in 96-well format in black, flat bottom plates (Santa Cruz Biotechnology) with a final volume of 100 μL. 25 μL of assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM225747(hsp90_44)
Affinity DataKd:  376nMAssay Description:Thermofluor AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM225782(hsp90_73)
Affinity DataKd:  393nMAssay Description:ITCMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails PubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Sanofi-Aventis Research And Development

Curated by ChEMBL
LigandPNGBDBM50249913((8S,9S,12S,13R,14S,16R)-19-(2-(azetidin-1-yl)ethyl...)
Affinity DataKd:  400nMAssay Description:Binding affinity to human recombinant HSP90More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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