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Found 874 Enz. Inhib. hit(s) with Target = 'Tryptophan 5-hydroxylase 1'
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50019142(CHEMBL3288777)
Affinity DataKd:  6.82E+3nMAssay Description:Binding affinity to TPH-1 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Rattus norvegicus)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50019142(CHEMBL3288777)
Affinity DataIC50:  6.22E+3nMAssay Description:Inhibition of TPH-1-mediated serotonin biosynthesis in rat RBL2H3 cells after 48 hrs by RP-HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Rattus norvegicus)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50019143(CHEMBL511275 | US10683309, Example LP533401)
Affinity DataIC50:  400nMAssay Description:Inhibition of TPH-1-mediated serotonin biosynthesis in rat RBL2H3 cells after 48 hrs by RP-HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243505((S)-2-amino-3-(4-(5-(cyclohexylmethylamino)pyrazin...)
Affinity DataIC50:  240nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243655((2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(3...)
Affinity DataIC50:  54nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243619((S) -2-amino-3-[4-(2-amino-6-[2,2,2-trifluoro-1-(2...)
Affinity DataIC50:  29nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243618((2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(2...)
Affinity DataIC50:  24nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243617((S)-2-Amino-3-(4-{2-amino-6-[2,2,2-trifluoro-1-(3'...)
Affinity DataIC50:  70nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243024((2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(n...)
Affinity DataIC50:  180nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243023((S)-2-amino-3-(4-(2-amino-6-((R)-1-(naphthalen-2-y...)
Affinity DataIC50:  380nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243022((S)-2-amino-3-(4-(2-amino-6-((R)-1-(naphthalen-2-y...)
Affinity DataIC50:  32nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50242933((S)-2-amino-3-(4-(5-((9-ethyl-9H-carbazol-3-yl)met...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50242932((S)-2-amino-3-(4-(6-(3-(cyclopentyloxy)-4-methoxyb...)
Affinity DataIC50:  970nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243616((S)-2-amino-3-(4'-(3-(cyclopentyloxy)-4-methoxy be...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243615(3-amino-3-(4-(4-amino-6-((S)-1-naphthalen-2-yl)eth...)
Affinity DataIC50:  3.77E+3nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243614(2-amino-3-(4-(4-amino-6-(R)-1-(naphthalene-2-yl)et...)
Affinity DataIC50:  1.11E+4nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243613((S)-2-Amino-3-(4-(4-amino-6-((naphthalene-2-ylmeth...)
Affinity DataIC50:  24nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243569((S)-2-amino-3-(3-(4-amino-6-((R)-1-(naphthalen-1-y...)
Affinity DataIC50:  1.26E+4nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243568((S)-2-amino-3-(1-(4-amino-6-((R)-1-(naphthalen-2-y...)
Affinity DataIC50:  770nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243567((S)-2-amino-3-(5-(4-amino-6-((R)-1-(naphthalen-1-y...)
Affinity DataIC50:  890nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243566(2-amino-3-(4(4-amino-6-(R)-1-(naphthalene-2-yl)eth...)
Affinity DataIC50: >1.10E+4nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243021(2-Amino-3-(4-(4-amino-6-(R)-1-(naphthalene-2-yl)et...)
Affinity DataIC50:  200nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243020((S)-2-amino-3-(4-(4-amino-6-((R)-1-(naphthalen-2-y...)
Affinity DataIC50:  26nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243019((S)-2-amino-3-(4-(5-((2'-methylbiphenyl-2-yl)methy...)
Affinity DataIC50:  40nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243018((S)-2-Amino-3-(4-{5-[(biphenyl-4-ylmethyl)-amino]-...)
Affinity DataIC50:  44nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50242930((S)-2-amino-3-(4-(5-(3,4-dimethoxybenzylamino)pyra...)
Affinity DataIC50:  69nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50242929((S)-2-amino-3-(4-(5-((9-ethyl-9H-carbazol-3-yl)met...)
Affinity DataIC50:  31nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50242928((S)-2-amino-3-{4-[5-(3-cyclopentyloxy-4-methoxy-be...)
Affinity DataIC50:  45nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243565((S)-2-amino-3-(4-(5-(naphthalen-2-ylmethylamino)py...)
Affinity DataIC50:  13nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243564((2S)-2-amino-3-(4-(5-((1,2,3,4-tetrahydronaphthale...)
Affinity DataIC50:  46nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243563((S)-2-amino-3-(4-{5-[(quinolin-3-ylmethyl)-amino]-...)
Affinity DataIC50:  190nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243562((S)-2-amino-3-(4-(5-(pyridine-2-ylmethylamino)pyra...)
Affinity DataIC50:  6.15E+3nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243507((S)-2-amino-3-(4-(5-(4-cyanobenzylamino)pyrazin-2-...)
Affinity DataIC50:  110nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243506((S)-2-amino-3-(4-(5-(furan-3-ylmethyl amino)pyrazi...)
Affinity DataIC50:  960nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Rattus norvegicus)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243022((S)-2-amino-3-(4-(2-amino-6-((R)-1-(naphthalen-2-y...)
Affinity DataEC50:  1.70E+3nMAssay Description:Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Rattus norvegicus)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243655((2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(3...)
Affinity DataEC50:  63nMAssay Description:Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Rattus norvegicus)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243619((S) -2-amino-3-[4-(2-amino-6-[2,2,2-trifluoro-1-(2...)
Affinity DataEC50:  70nMAssay Description:Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Rattus norvegicus)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243618((2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(2...)
Affinity DataEC50:  48nMAssay Description:Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Rattus norvegicus)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243617((S)-2-Amino-3-(4-{2-amino-6-[2,2,2-trifluoro-1-(3'...)
Affinity DataEC50:  56nMAssay Description:Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Rattus norvegicus)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243024((2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(n...)
Affinity DataEC50:  510nMAssay Description:Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Rattus norvegicus)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50243023((S)-2-amino-3-(4-(2-amino-6-((R)-1-(naphthalen-2-y...)
Affinity DataEC50:  1.10E+4nMAssay Description:Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50145634(CHEMBL3764999)
Affinity DataIC50:  26nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50145635(CHEMBL3764206)
Affinity DataIC50:  50nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50145636(CHEMBL3764034)
Affinity DataIC50:  55nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50145637(CHEMBL3765301)
Affinity DataIC50:  96nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50145638(CHEMBL3765770)
Affinity DataIC50:  211nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50145639(CHEMBL3764448)
Affinity DataIC50:  361nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50145640(CHEMBL3764208)
Affinity DataIC50:  449nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50145641(CHEMBL3765608)
Affinity DataIC50:  519nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50145642(CHEMBL3764344)
Affinity DataIC50:  949nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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