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Found 3760 Enz. Inhib. hit(s) with Target = 'Tumor necrosis factor'
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566086(CHEMBL4793441)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566082(CHEMBL4779359)
Affinity DataKd:  2.40nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50359044(CHEMBL1922178)
Affinity DataKd:  2.45nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50021403(Ganoderic Acid F)
Affinity DataKd:  2.69nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  3.81nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566088(CHEMBL4793924)
Affinity DataKd:  6.80nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566087(CHEMBL4787790)
Affinity DataKd:  7.30nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50359037(CHEMBL602899)
Affinity DataKd:  8nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50359040(CHEMBL1922174)
Affinity DataKd:  8nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50356915(GANODERIC ACID B)
Affinity DataKd:  8nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50021401(CHEMBL3289609)
Affinity DataKd:  13nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50552392(CHEMBL4743779)
Affinity DataKd:  13nMAssay Description:Binding affinity to human TNF measured after 2 hrs by surface plasmon resonanceMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50356920(CHEMBL1915761)
Affinity DataKd:  17nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50021402(Ganoderic Acid D)
Affinity DataKd:  19nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566081(CHEMBL4778232)
Affinity DataKd:  74nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 9(Homo sapiens)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50601008(CHEMBL5202442)
Affinity DataKd:  108nMAssay Description:Binding affinity to human recombinant CD137 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM228654((E)-4-(2-(4-chloro-3-nitrophenyl)) (C87))
Affinity DataKd:  110nMpH: 7.0Assay Description:Surface plasmon resonance (SPR) assays were carried out on a BIAcore 3000 instrument (Biacore, Inc). Briefly, purified hTNFα was dissolved at 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50378582(APIGETRIN | Apigenin 7-O-β-D-glucoside (8) | ...)
Affinity DataKd:  200nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor ligand superfamily member 11(Homo sapiens)
Shanghai Jiaotong University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50525149(CHEMBL4457006)
Affinity DataKd:  614nMAssay Description:Binding affinity to human RANKL by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50241242(2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen...)
Affinity DataKd:  790nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50021397(CHEMBL3289608)
Affinity DataKd:  1.82E+3nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor ligand superfamily member 11(Homo sapiens)
Shanghai Jiaotong University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50547333(CHEMBL3742191)
Affinity DataKd:  2.18E+3nMAssay Description:Binding affinity to GST-fused human RANKL extracellular domain (Lys159 to Asp317 residues) expressed in Escherichia coli BL21(DE3) pLysS by fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 9(Homo sapiens)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50601007(CHEMBL5176354)
Affinity DataKd:  2.37E+3nMAssay Description:Binding affinity to human CD137 assessed as dissociation constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566080(CHEMBL4783333)
Affinity DataKd:  2.70E+3nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair
TargetTumor necrosis factor ligand superfamily member 11(Homo sapiens)
Shanghai Jiaotong University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50525153(CHEMBL4560856)
Affinity DataKd:  2.70E+3nMAssay Description:Binding affinity to human RANKL by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTumor necrosis factor ligand superfamily member 11(Homo sapiens)
Shanghai Jiaotong University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50291908(CHEMBL4165601)
Affinity DataKd:  2.75E+3nMAssay Description:Binding affinity to recombinant human sRANKL expressed in Escherichia coli by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor ligand superfamily member 11(Homo sapiens)
Shanghai Jiaotong University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50547356(CHEMBL3742150)
Affinity DataKd:  2.82E+3nMAssay Description:Binding affinity to GST-fused human RANKL extracellular domain (Lys159 to Asp317 residues) expressed in Escherichia coli BL21(DE3) pLysS by fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTumor necrosis factor ligand superfamily member 11(Homo sapiens)
Shanghai Jiaotong University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50525147(CHEMBL4554653)
Affinity DataKd:  3.10E+3nMAssay Description:Binding affinity to human RANKL by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTumor necrosis factor ligand superfamily member 11(Homo sapiens)
Shanghai Jiaotong University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50525145(CHEMBL4454307)
Affinity DataKd:  3.50E+3nMAssay Description:Binding affinity to human RANKL by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTumor necrosis factor ligand superfamily member 11(Homo sapiens)
Shanghai Jiaotong University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50547353(CHEMBL3741922)
Affinity DataKd:  3.55E+3nMAssay Description:Binding affinity to GST-fused human RANKL extracellular domain (Lys159 to Asp317 residues) expressed in Escherichia coli BL21(DE3) pLysS by fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50545753(CHEMBL4649816)
Affinity DataKd:  4.26E+3nMAssay Description:Binding affinity to recombinant TNFalpha (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as Kd for TNF-alpha-TNFR1 binding at 10 u...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50575321(CHEMBL4851618)
Affinity DataKd:  4.40E+3nMAssay Description:Binding affinity to TNF (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTumor necrosis factor ligand superfamily member 11(Homo sapiens)
Shanghai Jiaotong University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50291909(CHEMBL4161101)
Affinity DataKd:  4.54E+3nMAssay Description:Binding affinity to recombinant human sRANKL expressed in Escherichia coli by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor ligand superfamily member 11(Homo sapiens)
Shanghai Jiaotong University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50547334(CHEMBL3741720)
Affinity DataKd:  4.60E+3nMAssay Description:Binding affinity to GST-fused human RANKL extracellular domain (Lys159 to Asp317 residues) expressed in Escherichia coli BL21(DE3) pLysS by fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTumor necrosis factor ligand superfamily member 11(Homo sapiens)
Shanghai Jiaotong University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50547347(CHEMBL3741778)
Affinity DataKd:  4.60E+3nMAssay Description:Binding affinity to GST-fused human RANKL extracellular domain (Lys159 to Asp317 residues) expressed in Escherichia coli BL21(DE3) pLysS by fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTumor necrosis factor ligand superfamily member 11(Homo sapiens)
Shanghai Jiaotong University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50547335(CHEMBL3741275)
Affinity DataKd:  4.60E+3nMAssay Description:Binding affinity to GST-fused human RANKL extracellular domain (Lys159 to Asp317 residues) expressed in Escherichia coli BL21(DE3) pLysS by fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTumor necrosis factor ligand superfamily member 11(Homo sapiens)
Shanghai Jiaotong University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50547343(CHEMBL4787527)
Affinity DataKd:  4.90E+3nMAssay Description:Binding affinity to GST-fused human RANKL extracellular domain (Lys159 to Asp317 residues) expressed in Escherichia coli BL21(DE3) pLysS by fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTumor necrosis factor ligand superfamily member 11(Homo sapiens)
Shanghai Jiaotong University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50594513(CHEMBL5187481)
Affinity DataKd:  5.03E+3nMAssay Description:Binding affinity to human RANKL assessed as dissociation constant by surface plasmon resonance methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50575304(CHEMBL4877313)
Affinity DataKd:  5.10E+3nMAssay Description:Binding affinity to TNF (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTumor necrosis factor ligand superfamily member 11(Homo sapiens)
Shanghai Jiaotong University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50547332(CHEMBL4756975)
Affinity DataKd:  5.24E+3nMAssay Description:Binding affinity to GST-fused human RANKL extracellular domain (Lys159 to Asp317 residues) expressed in Escherichia coli BL21(DE3) pLysS by fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTumor necrosis factor ligand superfamily member 11(Homo sapiens)
Shanghai Jiaotong University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50547358(CHEMBL3741437)
Affinity DataKd:  5.34E+3nMAssay Description:Binding affinity to GST-fused human RANKL extracellular domain (Lys159 to Asp317 residues) expressed in Escherichia coli BL21(DE3) pLysS by fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  5.36E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 5 % DMSO as solventMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  5.36E+3nMpH: 6.5Assay Description:Binding affinity to GST-tagged human TNF-alpha in 10 mM citrate-phosphate at pH 6.5 by fluorescence assayMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  5.70E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % DMSO as solventMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  5.75E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % PEG3350 as solventMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  6.18E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 5 % PEG3350 as solventMore data for this Ligand-Target Pair
TargetTumor necrosis factor ligand superfamily member 11(Homo sapiens)
Shanghai Jiaotong University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50525152(CHEMBL4514088)
Affinity DataKd:  6.30E+3nMAssay Description:Binding affinity to human RANKL measured after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTumor necrosis factor ligand superfamily member 11(Homo sapiens)
Shanghai Jiaotong University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50547344(CHEMBL4783826)
Affinity DataKd:  6.62E+3nMAssay Description:Binding affinity to GST-fused human RANKL extracellular domain (Lys159 to Asp317 residues) expressed in Escherichia coli BL21(DE3) pLysS by fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTumor necrosis factor ligand superfamily member 11(Homo sapiens)
Shanghai Jiaotong University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50525151(CHEMBL4470163)
Affinity DataKd:  7.30E+3nMAssay Description:Binding affinity to human RANKL measured after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  7.34E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 10 % DMSO as solventMore data for this Ligand-Target Pair
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