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Found 844 Enz. Inhib. hit(s) with Target = 'DNA damage-binding protein 1'
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM65456(19171-19-8 | 4-amino-2-(2,6-dioxopiperidin-3-yl)is...)
Affinity DataIC50:  1.20E+3nMpH: 7.0Assay Description:The 6XHis-tagged full length human CRBN bound to full length human DDB1 used in the assay was purified as described elsewhere with the exception that...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM65454(191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...)
Affinity DataIC50:  1.50E+3nMpH: 7.0Assay Description:The 6XHis-tagged full length human CRBN bound to full length human DDB1 used in the assay was purified as described elsewhere with the exception that...More data for this Ligand-Target Pair
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM65497(CC-220 (Compound 6) | US9694015, 6.4S)
Affinity DataIC50:  60nMpH: 7.0Assay Description:The 6XHis-tagged full length human CRBN bound to full length human DDB1 used in the assay was purified as described elsewhere with the exception that...More data for this Ligand-Target Pair
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM65454(191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...)
Affinity DataIC50:  3.00E+3nMpH: 8.0 T: 2°CAssay Description:Thermal stabilities of CRBN-DDB1 in the presence or absence of phthalimide, thalidomide, lenalidomide and pomalidomide were done in the presence of S...More data for this Ligand-Target Pair
TargetDNA damage-binding protein 1(Homo sapiens (Human))
Celgene

LigandPNGBDBM50070114((+/-)-thalidomide | 2-(2,6-Dioxo-piperidin-3-yl)-i...)
Affinity DataIC50:  3.00E+4nMpH: 8.0 T: 2°CAssay Description:Thermal stabilities of CRBN-DDB1 in the presence or absence of phthalimide, thalidomide, lenalidomide and pomalidomide were done in the presence of S...More data for this Ligand-Target Pair
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM65456(19171-19-8 | 4-amino-2-(2,6-dioxopiperidin-3-yl)is...)
Affinity DataIC50:  3.00E+3nMpH: 8.0 T: 2°CAssay Description:Thermal stabilities of CRBN-DDB1 in the presence or absence of phthalimide, thalidomide, lenalidomide and pomalidomide were done in the presence of S...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631074(N-[(3S)-2,6-dioxo-3-piperidyl]-2-phenyl-acetamide ...)
Affinity DataKd:  27nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631075(N-(2,6-Dioxopiperidin-3-yl)-2,3-dihydro-1H-indene-...)
Affinity DataKd:  655nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631076(N-(2,6-Dioxopiperidin-3-yl)-2-propylisoindoline-1-...)
Affinity DataKd:  57nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631077((−)-N-(2,6-Dioxopiperidin-3-yl)-2,3-dihydro-...)
Affinity DataKd:  68nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631078((+)-N-(2,6-Dioxopiperidin-3-yl)-2,3-dihydro-1H-ind...)
Affinity DataKd:  197nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631079(N-(2,6-Dioxopiperidin-3-yl)-2,3-dihydro-1H-indene-...)
Affinity DataKd:  146nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631080(N-(2,6-dioxo-3-piperidyl)-1H-indole-3-carboxamide ...)
Affinity DataKd:  28nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631081(N-(2,6-dioxo-3-piperidyl)-1-methyl-indole-3-carbox...)
Affinity DataKd:  30nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631082(N-(2,6-Dioxopiperidin-3-yl)indoline-1-carboxamide ...)
Affinity DataKd:  2nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631083(N-(2,6-dioxo-3-piperidyl)benzamide | US11802131, E...)
Affinity DataKd:  20nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631084(N-(2,6-dioxo-3-piperidyl)cyclopentanecarboxamide |...)
Affinity DataKd:  12nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631085(N-(2,6-dioxo-3-piperidyl)benzofuran-3-carboxamide ...)
Affinity DataKd:  2nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631086(N-(2,6-dioxo-3-piperidyl)benzothiophene-3-carboxam...)
Affinity DataKd:  8nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631087((1R)-N-(2,6-Dioxopiperidin-3-yl)-1,2,3,4-tetrahydr...)
Affinity DataKd:  4nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631088((1S)-N-(2,6-Dioxopiperidin-3-yl)-1,2,3,4-tetrahydr...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631089(N-(2,6-Dioxopiperidin-3-yl)-N-methyl-1H-indole-3-c...)
Affinity DataKd:  3nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631090(N-[(3S)-2,6-dioxo-3-piperidyl]-1H-indole-3-carboxa...)
Affinity DataKd:  14nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631091((R)-N-(2,6-Dioxopiperidin-3-yl)-1H-indole-3-carbox...)
Affinity DataKd:  14nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631092(N-((S)-2,6-Dioxopiperidin-3-yl)-6,7-dihydro-5H-cyc...)
Affinity DataKd:  1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631093(N-((R)-2,6-Dioxopiperidin-3-yl)-6,7-dihydro-5H-cyc...)
Affinity DataKd:  3nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631094((S)-N-(2,6-Dioxopiperidin-3-yl)benzofuran-3-carbox...)
Affinity DataKd:  1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631095((N-((R)-2,6-Dioxopiperidin-3-yl)-6,7-dihydro-5H-cy...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631096(N-((S)-2,6-Dioxopiperidin-3-yl)-6,7-dihydro-5H-cyc...)
Affinity DataKd:  25nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631097((R)-N-(2,6-Dioxopiperidin-3-yl)benzo[b]thiophene-3...)
Affinity DataKd:  9nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631098((S)-N-(2,6-Dioxopiperidin-3-yl)benzo[b]thiophene-3...)
Affinity DataKd:  23nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631099((S)-N-((R)-2,6-Dioxopiperidin-3-yl)-1,2,3,4-tetrah...)
Affinity DataKd:  6nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631100((S)-N-((S)-2,6-Dioxopiperidin-3-yl)-1,2,3,4-tetrah...)
Affinity DataKd:  3nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631101((S)-N-(2,6-Dioxopiperidin-3-yl)-3,4-dihydroquinoli...)
Affinity DataKd:  4nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631102((S)-N-(2,6-Dioxopiperidin-3-yl)-2,3-dihydro-1H-pyr...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631103((S)-N-(2,6-Dioxopiperidin-3-yl)-3,4-dihydro-1,8-na...)
Affinity DataKd:  4nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631104(N-[(3S)-2,6-Dioxo-3-piperidyl]chromane-4-carboxami...)
Affinity DataKd:  5nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631105((4S)-N-[(3S)-2,6-Dioxopiperidin-3-yl]-1,2,3,4-tetr...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631106((4R)-N-[(3S)-2,6-Dioxopiperidin-3-yl]-1,2,3,4-tetr...)
Affinity DataKd:  6nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631107((R)-N-(2,6-Dioxopiperidin-3-yl)benzofuran-3-carbox...)
Affinity DataKd:  26nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631108((R)-N-(2,6-Dioxopiperidin-3-yl)-3,4-dihydroquinoli...)
Affinity DataKd:  19nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631109((R)-N-(2,6-Dioxopiperidin-3-yl)-2,3-dihydro-1H-pyr...)
Affinity DataKd:  10nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631110(N-[(3S)-2,6-Dioxo-3-piperidyl]-1,2,3,4-tetrahydroq...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631111(N-[(3S)-2,6-Dioxo-3-piperidyl]-1-methyl-3,4-dihydr...)
Affinity DataKd:  5nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631112(N-[(3R)-2,6-Dioxo-3-piperidyl]-1,2,3,4-tetrahydroq...)
Affinity DataKd:  19nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631113(N-[(3R)-2,6-Dioxo-3-piperidyl]-1-methyl-3,4-dihydr...)
Affinity DataKd:  68nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631114(N-[(3R)-2,6-Dioxo-3-piperidyl]chromane-4-carboxami...)
Affinity DataKd:  14nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631115(Methyl (S)-3-((2,6-dioxopiperidin-3-yl)carbamoyl)-...)
Affinity DataKd:  18nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631116((4S)-N-[(3R)-2,6-Dioxopiperidin-3-yl]-1,2,3,4-tetr...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Celgene

LigandPNGBDBM631117((4R)-N-[(3R)-2,6-Dioxopiperidin-3-yl]-1,2,3,4-tetr...)
Affinity DataKd:  12nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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