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Found 775 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 9'
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM49152(5-chloranyl-7-[(4-ethylpiperazin-1-yl)-pyridin-3-y...)
Affinity DataIC50:  1.88E+3nMpH: 7.4Assay Description:Briefly, this fluorogenic assays uses an acetylated lysine tripeptide substrate, amide-linked to a fluorescently quenched aminocoumarin (AMC). Enzyme...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50: >3.33E+4nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM19422(4-(acetylamino)-N-(2-amino-phenyl) benzamide | CI-...)
Affinity DataIC50: >3.33E+4nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM178095(BRD2492)
Affinity DataIC50: >3.33E+4nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM178100(BRD3308 | US11377423, Cmpd 1)
Affinity DataIC50: >3.33E+4nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM36484((S)-Benzyl (6-acetamido-1-((4-methyl-2-oxo-2H-chro...)
Affinity DataIC50:  1.02E+3nMpH: 7.4 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM36483((S)-6-acetamido-2-(2-((S)-2-acetamido-4-methylpent...)
Affinity DataIC50:  2.34E+3nMpH: 7.4 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50:  2.68E+3nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50: >1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Affinity DataIC50: >1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)
Affinity DataIC50: >1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM50276074(CHEMBL470791 | HDAC inhibitor, Compound 2 | N-(2-a...)
Affinity DataIC50: >1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataIC50:  3.70E+3nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataIC50:  4.04E+3nMpH: 8.0Assay Description:Briefly, recombinant HDACs and substrates were diluted in reaction buffer (50 mM Tris-HCl, pH 8.0, 137 mM NaCl, 2.7mM KCl, 1mM MgCl2, 1 mg/ml BSA, 1%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM32188(CLIOQUINOL | Clioquinol (CQ) | TG2-36-2 | cid_2788)
Affinity DataIC50:  7.46E+4nMpH: 8.0Assay Description:Briefly, recombinant HDACs and substrates were diluted in reaction buffer (50 mM Tris-HCl, pH 8.0, 137 mM NaCl, 2.7mM KCl, 1mM MgCl2, 1 mg/ml BSA, 1%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM32188(CLIOQUINOL | Clioquinol (CQ) | TG2-36-2 | cid_2788)
Affinity DataIC50:  5.70E+4nMpH: 8.0Assay Description:Briefly, recombinant HDACs and substrates were diluted in reaction buffer (50 mM Tris-HCl, pH 8.0, 137 mM NaCl, 2.7mM KCl, 1mM MgCl2, 1 mg/ml BSA, 1%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM218163(US9249087, 6)
Affinity DataIC50:  1.45E+4nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM218161(US9249087, 4)
Affinity DataIC50:  1.83E+4nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM218159(US9249087, 2)
Affinity DataIC50:  8.16E+3nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM22449(CHEMBL356769 | N-(4-{(2R,4R,6S)-4-{[(4,5-diphenyl-...)
Affinity DataIC50: >3.00E+4nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM218226(US9249087, Table 1 , Compound 3)
Affinity DataIC50:  1.45E+4nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM218225(US9249087, Table 1 , Compound 2)
Affinity DataIC50:  1.83E+4nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM218224(US9249087, Table 1 , Compound 1)
Affinity DataIC50:  8.16E+3nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: >1.00E+5nMpH: 8.0Assay Description:Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Affinity DataIC50: >3.00E+4nMpH: 8.0 T: 2°CAssay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Affinity DataIC50:  4.31E+3nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataKi:  1.20nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataKi:  3.80nMAssay Description:Inhibition of human HDAC9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM50353234(CHEMBL1830537)
Affinity DataKi:  4.40nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataKi:  5.30nMAssay Description:Inhibition of human recombinant HDAC9 using fluorogenic HDAC substrate class 2a after 30 mins by fluorimetrc methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM50353233(CHEMBL1830536)
Affinity DataKi:  5.70nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM50319209(6-[3-(4-Bromo-benzoyl)-ureido]-hexanoic acid hydro...)
Affinity DataKi:  6nMAssay Description:Inhibition of HDAC9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM50517218(CHEMBL4525406)
Affinity DataKi:  8nMAssay Description:Inhibition of HDAC9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM50353232(CHEMBL1830424)
Affinity DataKi:  11nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM50353229(CHEMBL1830397)
Affinity DataKi:  11nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM50353230(CHEMBL1830420)
Affinity DataKi:  14nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM50353231(CHEMBL1830422)
Affinity DataKi:  16nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM50248476(CHEMBL491316 | N-hydroxy-3-(2-phenethyl-1-(2-(pyrr...)
Affinity DataKi:  19nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM50248476(CHEMBL491316 | N-hydroxy-3-(2-phenethyl-1-(2-(pyrr...)
Affinity DataKi:  19nMAssay Description:Inhibition of recombinant HDAC9 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataKi:  19nMAssay Description:Inhibition of human HDAC9 using (Boc-Lys(trifluoroacetyl)-AMC) as substrate measured after 2 hrs by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM50353227(CHEMBL3215861)
Affinity DataKi:  19nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM50248570(3-(1-(3-(dimethylamino)-2,2-dimethylpropyl)-2-phen...)
Affinity DataKi:  21nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataKi:  24nMAssay Description:Inhibition of human HDAC9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM50248522(CHEMBL489332 | N-hydroxy-3-(2-phenethyl-1-(2-(pipe...)
Affinity DataKi:  24nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)
Affinity DataKi:  24nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM50353228(CHEMBL1830396)
Affinity DataKi:  30nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataKi:  49nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM50319235(6-(3-Benzoyl-ureido)-hexanoic acid hydroxyamide | ...)
Affinity DataKi:  55nMAssay Description:Inhibition of HDAC9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataKi:  65nMAssay Description:Inhibition of HDAC9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)
Affinity DataKi:  250nMAssay Description:Inhibition of human HDAC9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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