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Found 147 Enz. Inhib. hit(s) with Target = 'Inositol 1,4,5-trisphosphate receptor'
TargetInositol 1,4,5-trisphosphate receptor type 3(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50078572(CHEMBL172534 | CHEMBL297496 | {4-[(4-Dimethylamino...)
Affinity DataKd:  1.20nMpH: 7.4Assay Description:Dissociation constant of compound was measured in IP3-binding domain(IBD) of human Inositol 1,4,5-trisphosphate receptor at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 3(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50078573(CHEMBL297235 | Phosphoric acid 3-amino-propyl este...)
Affinity DataKd:  1.12E+3nMpH: 7.4Assay Description:Dissociation constant of compound was measured in IP3-binding domain(IBD) of human Inositol 1,4,5-trisphosphate receptor at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 3(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50075183(1,4,5-Insp3 | 1D-myo-inositol 1,4,5-triphosphate |...)
Affinity DataKd:  195nMpH: 7.4Assay Description:Dissociation constant of compound was measured in IP3-binding domain(IBD) of human Inositol 1,4,5-trisphosphate receptor at pH 7.4More data for this Ligand-Target Pair
TargetInositol 1,4,5-trisphosphate receptor type 3(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50078574(CHEMBL46273 | inositol 1,4,5-trisphosphate analogu...)
Affinity DataKd:  188nMpH: 7.4Assay Description:Dissociation constant of compound was measured in IP3-binding domain(IBD) of human Inositol 1,4,5-trisphosphate receptor at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50132166(1,2,4,5-InsP4 | CHEMBL100498 | Phosphoric acid mon...)
Affinity DataKi:  26.4nMAssay Description:Compound was evaluated for its ability to displace [3H]Ins(1,4,5)P3 from membranes prepared from bovine adrenal corticlesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetInositol 1,4,5-trisphosphate receptor type 1/2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50211666(CHEMBL1161456)
Affinity DataKi:  2.92E+5nMAssay Description:Compound was evaluated for its ability to inhibit Inositol phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetInositol 1,4,5-trisphosphate receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50075183(1,4,5-Insp3 | 1D-myo-inositol 1,4,5-triphosphate |...)
Affinity DataIC50:  300nMAssay Description:Binding affinity against Ins(1,4,5)P3 receptor in swiss 3T3 cellsMore data for this Ligand-Target Pair
TargetInositol 1,4,5-trisphosphate receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50111931(CHEMBL434103 | Phosphoric acid 3-(4-pyren-1-yl-but...)
Affinity DataKd:  140nMAssay Description:Dissociation constant of the compound was determined using IP3-binding domain (IBD) of human Type 1 inositol 1,4,5-trisphosphate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50069313(CHEMBL158474 | Phosphoric acid mono-((1S,2S,3R,4S,...)
Affinity DataIC50:  598nMAssay Description:Binding affinity towards Inositol 1,4,5-trisphosphate receptor was evaluated by the standard competitive binding assay using 1.25 nM [3H]-D-I(1,4,5)P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50069314(CHEMBL346769 | D-MYO-INOSITOL 1,2,4,5-TETRAKISPHOS...)
Affinity DataIC50:  13nMAssay Description:Binding affinity towards Inositol 1,4,5-trisphosphate receptor was evaluated by the standard competitive binding assay using 1.25 nM [3H]-D-I(1,4,5)P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 3(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50075647(CHEMBL283791 | Phosphoric acid mono-((1R,2S,3R,4S,...)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of Ins(1,3,4,5)P4-PtdIns(3,4,5)P3-specific receptor from Pig cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 3(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50075648((1R,3S,4R,6R)-4,5,6-trihydroxy-2-methyl-2,3-bis(ph...)
Affinity DataIC50:  44nMAssay Description:Inhibition of Ins(1,3,4,5)P4-PtdIns(3,4,5)P3-specific receptor from Pig cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 3(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50075649(1D-myo-inositol 1,4,5,6-tetrakis(dihydrogen phosph...)
Affinity DataIC50:  430nMAssay Description:Inhibition of Ins(1,3,4,5)P4-PtdIns(3,4,5)P3-specific receptor from Pig cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 3(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50075650(1D-myo-inositol 3,4,5,6-tetrakisphosphate | 1L-myo...)
Affinity DataIC50:  620nMAssay Description:Inhibition of Ins(1,3,4,5)P4-PtdIns(3,4,5)P3-specific receptor from Pig cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 3(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50075651(1D-myo-inositol 1,3,4,5-tetrakis(dihydrogen phosph...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of Ins(1,3,4,5)P4-PtdIns(3,4,5)P3-specific receptor from Pig cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50082885(CHEMBL144954 | Phosphoric acid mono-((1R,2R,3S,4R,...)
Affinity DataIC50:  1.00E+3nMAssay Description:Binding affinity against Inositol 1,4,5-trisphosphate receptor on bovine adrenal cortex microsomes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50082886(CHEMBL355920 | Phosphoric acid mono-((1R,2R,3R,4R,...)
Affinity DataIC50:  3.00E+3nMAssay Description:Binding affinity against Inositol 1,4,5-trisphosphate receptor on bovine adrenal cortex microsomes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50082887(CHEMBL18162 | Phosphoric acid mono-((1R,2S,3S,4R,5...)
Affinity DataIC50:  2.00E+3nMAssay Description:Binding affinity against Inositol 1,4,5-trisphosphate receptor on bovine adrenal cortex microsomes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50082888(CHEMBL278700 | Phosphoric acid mono-((1R,3R,4R)-3,...)
Affinity DataIC50:  3.90E+3nMAssay Description:Binding affinity against Inositol 1,4,5-trisphosphate receptor on bovine adrenal cortex microsomes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50082889(CHEMBL145009 | Phosphoric acid mono-((1R,2S,3S,4R,...)
Affinity DataIC50:  5.00E+3nMAssay Description:Binding affinity against Inositol 1,4,5-trisphosphate receptor on bovine adrenal cortex microsomes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50075183(1,4,5-Insp3 | 1D-myo-inositol 1,4,5-triphosphate |...)
Affinity DataIC50:  1.40E+4nMAssay Description:Binding affinity against Inositol 1,4,5-trisphosphate receptor on bovine adrenal cortex microsomes.More data for this Ligand-Target Pair
TargetInositol 1,4,5-trisphosphate receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50078573(CHEMBL297235 | Phosphoric acid 3-amino-propyl este...)
Affinity DataKd:  1.50E+3nMAssay Description:Dissociation constant of the compound was determined using IP3-binding domain (IBD) of human Type 1 inositol 1,4,5-trisphosphate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50078572(CHEMBL172534 | CHEMBL297496 | {4-[(4-Dimethylamino...)
Affinity DataKd:  1.20nMAssay Description:Dissociation constant of the compound was determined using IP3-binding domain (IBD) of human Type 1 inositol 1,4,5-trisphosphate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50111928(CHEMBL169923 | Phosphoric acid 3-[(naphthalene-1-c...)
Affinity DataKd:  160nMAssay Description:Dissociation constant of the compound was determined using IP3-binding domain (IBD) of human Type 1 inositol 1,4,5-trisphosphate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50111932(CHEMBL369479 | inositol 1,4,5-Trisphosphate analog...)
Affinity DataKd:  620nMAssay Description:Dissociation constant of the compound was determined using IP3-binding domain (IBD) of human Type 1 inositol 1,4,5-trisphosphate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50075183(1,4,5-Insp3 | 1D-myo-inositol 1,4,5-triphosphate |...)
Affinity DataKd:  260nMAssay Description:Dissociation constant of the compound was determined using IP3-binding domain (IBD) of human Type 1 inositol 1,4,5-trisphosphate receptorMore data for this Ligand-Target Pair
TargetInositol 1,4,5-trisphosphate receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50111929(CHEMBL352326 | Phosphoric acid 3-{4-[bis-(4-dimeth...)
Affinity DataKd:  3.20E+3nMAssay Description:Dissociation constant of the compound was determined using IP3-binding domain (IBD) of human Type 1 inositol 1,4,5-trisphosphate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50184323(CHEMBL379040 | phosphoric acid mono-{(2R,3R,4R,5R,...)
Affinity DataEC50:  4.60nMAssay Description:Agonistic potency at rat IP3 type 1 receptor expressed in chicken DT40 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50184324(CHEMBL383049 | phosphoric acid mono-{(2R,3R,4R,5S,...)
Affinity DataEC50:  4nMAssay Description:Agonistic potency at rat IP3 type 1 receptor expressed in chicken DT40 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50184326(CHEMBL380941 | phosphoric acid mono-[(2R,3R,4R,5S,...)
Affinity DataEC50:  213nMAssay Description:Agonistic potency at rat IP3 type 1 receptor expressed in chicken DT40 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50184329(CHEMBL383659 | phosphoric acid mono-((2R,3R,4R,5S,...)
Affinity DataEC50:  1.08E+3nMAssay Description:Agonistic potency at rat IP3 type 1 receptor expressed in chicken DT40 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50184325(2-[5-(6-amino-9H-9-purinyl)-2-hydroxymethyl-4-oxyp...)
Affinity DataEC50:  2.10nMAssay Description:Agonistic potency at rat IP3 type 1 receptor expressed in chicken DT40 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50184328(CHEMBL204903 | phosphoric acid mono-[(2R,3R,4R,5S,...)
Affinity DataEC50:  2.04E+3nMAssay Description:Agonistic potency at rat IP3 type 1 receptor expressed in chicken DT40 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50075183(1,4,5-Insp3 | 1D-myo-inositol 1,4,5-triphosphate |...)
Affinity DataEC50:  24.8nMAssay Description:Agonistic potency at rat IP3 type 1 receptor expressed in chicken DT40 cellsMore data for this Ligand-Target Pair
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50184327(CHEMBL205303 | phosphoric acid mono-[(2R,3R,4R,5S,...)
Affinity DataEC50:  4.43E+3nMAssay Description:Agonistic potency at rat IP3 type 1 receptor expressed in chicken DT40 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50184331(CHEMBL204253 | phosphoric acid mono-((2R,3R,4R,5S,...)
Affinity DataEC50:  394nMAssay Description:Agonistic potency at rat IP3 type 1 receptor expressed in chicken DT40 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50184332(CHEMBL382185 | phosphoric acid mono-{(2R,3R,4R,5S,...)
Affinity DataEC50:  11.3nMAssay Description:Agonistic potency at rat IP3 type 1 receptor expressed in chicken DT40 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50184330(CHEMBL205008 | phosphoric acid mono-[(2R,3R,4R,5S,...)
Affinity DataEC50:  49.2nMAssay Description:Agonistic potency at rat IP3 type 1 receptor expressed in chicken DT40 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50075183(1,4,5-Insp3 | 1D-myo-inositol 1,4,5-triphosphate |...)
Affinity DataEC50:  20nMAssay Description:Agonist activity at rat recombinant IP3R1 expressed in chicken DT40 cells assessed as calcium release from intracellular storesMore data for this Ligand-Target Pair
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50184325(2-[5-(6-amino-9H-9-purinyl)-2-hydroxymethyl-4-oxyp...)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at rat recombinant IP3R1 expressed in chicken DT40 cells assessed as calcium release from intracellular storesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50323704(CHEMBL1213158)
Affinity DataEC50:  2.70nMAssay Description:Agonist activity at rat recombinant IP3R1 expressed in chicken DT40 cells assessed as calcium release from intracellular storesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50323705(CHEMBL1213159)
Affinity DataEC50:  4.90nMAssay Description:Agonist activity at rat recombinant IP3R1 expressed in chicken DT40 cells assessed as calcium release from intracellular storesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50323706(CHEMBL1212943)
Affinity DataEC50:  5nMAssay Description:Agonist activity at rat recombinant IP3R1 expressed in chicken DT40 cells assessed as calcium release from intracellular storesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50323707(CHEMBL1213160)
Affinity DataEC50:  5nMAssay Description:Agonist activity at rat recombinant IP3R1 expressed in chicken DT40 cells assessed as calcium release from intracellular storesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50323708(CHEMBL1213161)
Affinity DataEC50:  21nMAssay Description:Agonist activity at rat recombinant IP3R1 expressed in chicken DT40 cells assessed as calcium release from intracellular storesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50323709(CHEMBL1213163)
Affinity DataEC50:  30nMAssay Description:Agonist activity at rat recombinant IP3R1 expressed in chicken DT40 cells assessed as calcium release from intracellular storesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50323710((1R,2R,3S,4R,6S)-3,6-dihydroxycyclohexane-1,2,4-tr...)
Affinity DataEC50:  32nMAssay Description:Agonist activity at rat recombinant IP3R1 expressed in chicken DT40 cells assessed as calcium release from intracellular storesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50323711((1R,2R,3S,4S,5R,6S)-5-(2-aminoethoxy)-3,6-dihydrox...)
Affinity DataEC50:  42nMAssay Description:Agonist activity at rat recombinant IP3R1 expressed in chicken DT40 cells assessed as calcium release from intracellular storesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50075183(1,4,5-Insp3 | 1D-myo-inositol 1,4,5-triphosphate |...)
Affinity DataKd:  12.5nMAssay Description:Displacement of [3H]IP3 from full-length rat recombinant IP3R1 expressed in chicken DT40 cells by equilibrium competitive binding assayMore data for this Ligand-Target Pair
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50184325(2-[5-(6-amino-9H-9-purinyl)-2-hydroxymethyl-4-oxyp...)
Affinity DataKd:  1.26nMAssay Description:Displacement of [3H]IP3 from full-length rat recombinant IP3R1 expressed in chicken DT40 cells by equilibrium competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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