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Found 587 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase HCK'
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM81374(BODIPY-labeled probe, 4a)
Affinity DataKd:  8.70nMpH: 7.5Assay Description:In vitro activity assay using various kinases.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM81375(Amine compound, 12a)
Affinity DataIC50:  9.60nMpH: 7.5Assay Description:In vitro activity assay using various kinases.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM81376(Amine compound, 13a)
Affinity DataIC50:  6.30nMpH: 7.5Assay Description:In vitro activity assay using various kinases.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM93207(Kinase inhibitor, 5)
Affinity DataIC50: <0.5nMpH: 7.5 T: 2°CAssay Description:Fluorescence assay used for determination of catch and release efficiency. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM50430875(CHEMBL2336005 | US9062066, LCB 03-0110)
Affinity DataIC50:  4.40nMpH: 8.0Assay Description:The inhibitory activity measurement against the kinases mentioned above was measured in the kinase inhibition reaction mixture containing 2 ul purifi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM50430875(CHEMBL2336005 | US9062066, LCB 03-0110)
Affinity DataIC50:  50.7nMpH: 8.0Assay Description:The inhibitory activity measurement against the kinases mentioned above was measured in the kinase inhibition reaction mixture containing 2 ul purifi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM50437405(CHEMBL2408778)
Affinity DataKi:  504nMAssay Description:Inhibition of HCK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM50119568(CHEMBL3617738)
Affinity DataKi:  730nMAssay Description:Inhibition of Hck (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM50119566(CHEMBL3617732)
Affinity DataKi:  980nMAssay Description:Inhibition of Hck (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM50341519((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of HCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM50119567(CHEMBL3617740)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of Hck (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM50354476(CHEMBL1836673)
Affinity DataKi:  1.72E+3nMAssay Description:Inhibition human recombinant HcK using KVEKIGEGTYGVVYK peptide substrate in presence of [gamma-32P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM50463479(CHEMBL4249925)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of HCK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM50463483(CHEMBL4245242)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of HCK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM50354480(CHEMBL1836678)
Affinity DataKi:  3.87E+3nMAssay Description:Inhibition human recombinant HcK using KVEKIGEGTYGVVYK peptide substrate in presence of [gamma-32P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM50354481(CHEMBL1836679)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition human recombinant HcK using KVEKIGEGTYGVVYK peptide substrate in presence of [gamma-32P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM50119571(CHEMBL3617729)
Affinity DataKi: >1.25E+6nMAssay Description:Inhibition of Hck (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM14807(3-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-pr...)
Affinity DataIC50:  1.28E+4nMT: 2°CAssay Description:In vitro kinase activity of Nef-Hck complex and Hck alone using Z'-lyte kinase assay system and Tyr2 peptide substrate from Invitrogen.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM36544(DFP-4AB | Diphenylfuropyrimidine-4-aminobutanol)
Affinity DataIC50: >3.00E+4nMT: 2°CAssay Description:In vitro kinase activity of Nef-Hck complex and Hck alone using Z'-lyte kinase assay system and Tyr2 peptide substrate from Invitrogen.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM36545(DFP-4APF | diphenylfuropyrimidine-4-aminopropylfur...)
Affinity DataIC50: >3.00E+4nMT: 2°CAssay Description:In vitro kinase activity of Nef-Hck complex and Hck alone using Z'-lyte kinase assay system and Tyr2 peptide substrate from Invitrogen.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM14806(5,6-Diphenyl-furo[2,3-d]pyrimidin-4 -ylamine | 5,6...)
Affinity DataIC50: >3.00E+4nMT: 2°CAssay Description:In vitro kinase activity of Nef-Hck complex and Hck alone using Z'-lyte kinase assay system and Tyr2 peptide substrate from Invitrogen.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM31085(1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluorom...)
Affinity DataKd:  880nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM26300(2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}qu...)
Affinity DataKd:  3.90E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM25118((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)
Affinity DataKd:  3.30E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM31088(1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-y...)
Affinity DataKd:  1.20E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM4779(CHEMBL31965 | CHEMBL545315 | CI-1033 | Canertinib ...)
Affinity DataKd:  4.20E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataKd:  0.350nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM31090((E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-eth...)
Affinity DataKd:  2.30E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataKd:  1.80E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataKd:  4.40E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM31093(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)
Affinity DataKd:  1.50E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM31094(PKC-412 | cid_24202429)
Affinity DataKd:  720nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  2.20E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705)
Affinity DataKd:  20nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataKd:  880nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM21(CHEMBL24828 | N-(4-bromo-2-fluorophenyl)-6-methoxy...)
Affinity DataKd:  360nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM47094(US8933228, 22)
Affinity DataIC50:  458nMAssay Description:The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50: >1.89E+3nMAssay Description:The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM142597(US8933228, Ref 1)
Affinity DataIC50:  47nMAssay Description:The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM142598(US10238658, Example Reference | US10813932, Refere...)
Affinity DataIC50:  3nMAssay Description:The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM142599(US8933228, 1)
Affinity DataIC50: <2nMAssay Description:The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM142600(US8933228, 2)
Affinity DataIC50: <2nMAssay Description:The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM142601(US8933228, 3)
Affinity DataIC50:  2nMAssay Description:The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM142602(US8933228, 4)
Affinity DataIC50:  7nMAssay Description:The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM142603(US8933228, 5)
Affinity DataIC50:  3nMAssay Description:The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM142604(US8933228, 6)
Affinity DataIC50:  3nMAssay Description:The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM142605(US8933228, 7)
Affinity DataIC50:  3nMAssay Description:The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM142606(US8933228, 8)
Affinity DataIC50:  5nMAssay Description:The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM142618(US8933228, 9)
Affinity DataIC50: <2nMAssay Description:The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington

LigandPNGBDBM142619(US8933228, 10)
Affinity DataIC50:  3nMAssay Description:The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...More data for this Ligand-Target Pair
In DepthDetails US Patent
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