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Found 442 Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 7B'
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM123687(US8741907, 3 | US9067945, 2)
Affinity DataIC50: >4.00E+3nMpH: 7.5Assay Description:The test substances are dissolved in 100% DMSO and serially diluted to determine their in vitro effect on PDE 9A. Typically, serial dilutions from 20...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM123687(US8741907, 3 | US9067945, 2)
Affinity DataIC50: >4.00E+3nMpH: 7.5Assay Description:The test substances are dissolved in 100% DMSO and serially diluted to determine their in vitro effect on PDE 9A. 2 uL portions of the diluted substa...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM116311(US8637528, OM955)
Affinity DataIC50:  106nMpH: 8.0Assay Description:The assay method used was a scintillation proximity assay (SPA) (obtained from GE Healthcare, Product Code TRKQ7100), with [3H]-cGMP as the substrate...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50151526(CHEMBL363097 | N-(4-{5-[(Z)-Cyclohexylimino]-4-met...)
Affinity DataIC50:  144nMpH: 8.0Assay Description:The assay method used was a scintillation proximity assay (SPA) (obtained from GE Healthcare, Product Code TRKQ7100), with [3H]-cGMP as the substrate...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM116309(US8637528, OM69)
Affinity DataIC50:  4.80nMpH: 8.0Assay Description:The assay method used was a scintillation proximity assay (SPA) (obtained from GE Healthcare, Product Code TRKQ7100), with [3H]-cGMP as the substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM116310(US8637528, OM056)
Affinity DataIC50:  9.27nMpH: 8.0Assay Description:The assay method used was a scintillation proximity assay (SPA) (obtained from GE Healthcare, Product Code TRKQ7100), with [3H]-cGMP as the substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50150264(CHEMBL3769817)
Affinity DataKi:  300nMAssay Description:Inhibition of recombinant full lenght human PDE7B using fluorescent labeled cAMP as substrate after 15 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50150119(CHEMBL3769414)
Affinity DataKi:  360nMAssay Description:Inhibition of recombinant full lenght human PDE7B using fluorescent labeled cAMP as substrate after 15 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50150171(CHEMBL3770470)
Affinity DataKi:  910nMAssay Description:Inhibition of recombinant full lenght human PDE7B using fluorescent labeled cAMP as substrate after 15 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50150239(CHEMBL3769461)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of recombinant full lenght human PDE7B using fluorescent labeled cAMP as substrate after 15 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50150238(CHEMBL3770107)
Affinity DataKi:  6.10E+3nMAssay Description:Inhibition of recombinant full lenght human PDE7B using fluorescent labeled cAMP as substrate after 15 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14769(6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-...)
Affinity DataIC50: >2.00E+5nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50: >2.00E+5nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14771((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Affinity DataIC50:  990nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14774(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)
Affinity DataIC50: >2.00E+5nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14772((R,S)-Mesopram | 5-(4-methoxy-3-propoxy-phenyl)-5-...)
Affinity DataIC50: >2.00E+5nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50:  8.80E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  7.80E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14776(2-{2-ethoxy-5-[(4-ethylpiperazine-1-)sulfonyl]phen...)
Affinity DataIC50:  1.90E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataIC50:  7.40E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14773(4-cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)cyclo...)
Affinity DataIC50:  4.40E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50028917(CHEMBL3359103)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of human recombinant PDE7B assessed as inhibition of hydrolysis of [3H]cAMP after 20 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50028925(CHEMBL3359111)
Affinity DataIC50:  1.41E+3nMAssay Description:Inhibition of human recombinant PDE7B assessed as inhibition of hydrolysis of [3H]cAMP after 20 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50028926(CHEMBL3359624)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human recombinant PDE7B assessed as inhibition of hydrolysis of [3H]cAMP after 20 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50028927(CHEMBL196910)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human recombinant PDE7B assessed as inhibition of hydrolysis of [3H]cAMP after 20 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50028886(CHEMBL3359633)
Affinity DataIC50:  600nMAssay Description:Inhibition of human recombinant PDE7B assessed as inhibition of hydrolysis of [3H]cAMP after 20 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50028887(CHEMBL3359635)
Affinity DataIC50:  1.39E+4nMAssay Description:Inhibition of human recombinant PDE7B assessed as inhibition of hydrolysis of [3H]cAMP after 20 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE7bMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50259057(3-isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-py...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE7bMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50259108((-)3-Isopropyl-5-{[(trans)-2-(pyrimidin-2-ylamino)...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE7bMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50180268(CHEMBL3814662)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PDE7BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of PDE7BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of PDE7BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50300113(1-cyclopentyl-6-[(3S,4S)-4-methyl-1-(quinoxalin-6-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE7BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50308557(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of PDE7BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50319163(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE7BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of PDE7BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50334653(5-((1H-benzo[d]imidazol-2-yl)methylthio)-2-methyl-...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of PDE7BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50334670(2,9-Dimethyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of PDE7BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50357234(CHEMBL1916475)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of PDE7BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50397838(CHEMBL2179105 | PF-04447943 | US10513524, Referenc...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE7BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50397052(CHEMBL2171423)
Affinity DataIC50:  19nMAssay Description:Inhibition of cloned human recombinant PDE7B assessed as [3H]cAMP hydrolysis by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50397053(CHEMBL2171422)
Affinity DataIC50:  11nMAssay Description:Inhibition of cloned human recombinant PDE7B assessed as [3H]cAMP hydrolysis by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM50397054(CHEMBL2171421)
Affinity DataIC50:  43nMAssay Description:Inhibition of cloned human recombinant PDE7B assessed as [3H]cAMP hydrolysis by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM607104(US11685745, Example 37)
Affinity DataIC50: <10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM607105(US11685745, Example 43)
Affinity DataIC50: <10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM607106(US11685745, Example 51)
Affinity DataIC50: <10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM607107(US11685745, Example 64)
Affinity DataIC50: <10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM607108(US11685745, Example 79)
Affinity DataIC50: <10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Boehringer Ingehleim International

US Patent
LigandPNGBDBM607109(US11685745, Example 123)
Affinity DataIC50: <10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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