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Compile Data Set for Download or QSAR

Found 377 hits Enz. Inhib. hit(s) with Target = 'Acetylcholine Binding protein'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50088453
PNG
(1-(6-Bromo-5-ethoxy-pyridin-3-yl)-[1,4]diazepane |...)
Show SMILES CCOc1cc(cnc1Br)N1CCCNCC1
Show InChI InChI=1S/C12H18BrN3O/c1-2-17-11-8-10(9-15-12(11)13)16-6-3-4-14-5-7-16/h8-9,14H,2-7H2,1H3
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0.0670n/an/an/an/an/an/an/an/a



University of Copenhagen



Assay Description
Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...


J Biol Chem 287: 4248-59 (2012)


Article DOI: 10.1074/jbc.M111.292243
BindingDB Entry DOI: 10.7270/Q2J964Z5
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50143314
PNG
((+)-Epibatidine | (-)-epibatidine | (1R,2R,4S)-2-(...)
Show SMILES Clc1ccc(cn1)[C@H]1C[C@@H]2CC[C@H]1N2
Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2/t8-,9+,10+/m0/s1
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0.0970n/an/an/an/an/an/an/an/a



University of Copenhagen



Assay Description
Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...


J Biol Chem 287: 4248-59 (2012)


Article DOI: 10.1074/jbc.M111.292243
BindingDB Entry DOI: 10.7270/Q2J964Z5
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50049757
PNG
(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Show SMILES Clc1ccc(cn1)C1CC2CCC1N2
Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2
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0.300n/an/an/an/an/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Binding affinity to freshwater snail Lymnaea stagnalis AChBP assessed as [3H]EPI binding by radioligand binding assay


J Agric Food Chem 59: 2825-8 (2011)


Article DOI: 10.1021/jf1019455
BindingDB Entry DOI: 10.7270/Q2GF0XCJ
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Aplysia Californica)
BDBM50472282
PNG
(DESCYANOTHIACLOPRID | descyanothiacloprid)
Show SMILES Clc1ccc(CN2CCSC2=N)cn1
Show InChI InChI=1S/C9H10ClN3S/c10-8-2-1-7(5-12-8)6-13-3-4-14-9(13)11/h1-2,5,11H,3-4,6H2
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0.600n/an/an/an/an/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Binding affinity to salt water mollusc Aplysia californica AChBP Y55W mutant assessed as [3H]acetamiprid binding by radioligand binding assay


J Agric Food Chem 59: 2825-8 (2011)


Article DOI: 10.1021/jf1019455
BindingDB Entry DOI: 10.7270/Q2GF0XCJ
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50520722
PNG
(CHEMBL4554047)
Show SMILES Clc1ccc(C[C@@]2(COc3cccnc3)CCCNC2)cc1Cl
Show InChI InChI=1S/C18H20Cl2N2O/c19-16-5-4-14(9-17(16)20)10-18(6-2-8-22-12-18)13-23-15-3-1-7-21-11-15/h1,3-5,7,9,11,22H,2,6,8,10,12-13H2/t18-/m0/s1
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0.860n/an/an/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein incubated for 60 mins followed by 3 hrs incubation in dark condi...


Eur J Med Chem 160: 37-48 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.073
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Aplysia Californica)
BDBM50049757
PNG
(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Show SMILES Clc1ccc(cn1)C1CC2CCC1N2
Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2
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1n/an/an/an/an/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Binding affinity to salt water mollusc Aplysia californica AChBP Y55W mutant assessed as [3H]acetamiprid binding by radioligand binding assay


J Agric Food Chem 59: 2825-8 (2011)


Article DOI: 10.1021/jf1019455
BindingDB Entry DOI: 10.7270/Q2GF0XCJ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50088454
PNG
(1-(6-Bromo-pyridin-3-yl)-[1,4]diazepane | 1-(6-bro...)
Show SMILES Brc1ccc(cn1)N1CCCNCC1
Show InChI InChI=1S/C10H14BrN3/c11-10-3-2-9(8-13-10)14-6-1-4-12-5-7-14/h2-3,8,12H,1,4-7H2
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1.30n/an/an/an/an/an/an/an/a



University of Copenhagen



Assay Description
Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...


J Biol Chem 287: 4248-59 (2012)


Article DOI: 10.1074/jbc.M111.292243
BindingDB Entry DOI: 10.7270/Q2J964Z5
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM91624
PNG
(alpha7 agonists 4t)
Show SMILES CN1[C@H]2CC[C@@H]1C[C@H](C2)n1cc(COc2cc(=O)n(C)c3ccccc23)nn1
Show InChI InChI=1S/C21H25N5O2/c1-24-15-7-8-16(24)10-17(9-15)26-12-14(22-23-26)13-28-20-11-21(27)25(2)19-6-4-3-5-18(19)20/h3-6,11-12,15-17H,7-10,13H2,1-2H3/t15-,16+,17-
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1.30 -49.9n/an/an/an/an/a7.420



University of California San Diego



Assay Description
Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 ?l of 0.2 mg/ml an...


Mol Pharmacol 82: 687-699 (2014)


Article DOI: 10.1124/mol.112.080291
BindingDB Entry DOI: 10.7270/Q2805163
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Aplysia Californica)
BDBM50487234
PNG
(CHEMBL1391421)
Show SMILES [O-][N+](=O)\C=C1/NCCN1Cc1ccc(Cl)nc1
Show InChI InChI=1S/C10H11ClN4O2/c11-9-2-1-8(5-13-9)6-14-4-3-12-10(14)7-15(16)17/h1-2,5,7,12H,3-4,6H2/b10-7+
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1.70n/an/an/an/an/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Binding affinity to salt water mollusc Aplysia californica AChBP Y55W mutant assessed as [3H]acetamiprid binding by radioligand binding assay


J Agric Food Chem 59: 2825-8 (2011)


Article DOI: 10.1021/jf1019455
BindingDB Entry DOI: 10.7270/Q2GF0XCJ
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM91603
PNG
(4' | alpha7 agonists 4')
Show SMILES CN1CC=C(OCc2cnnn2C2CC3CCC(C2)[N+]3(C)C)c2ccccc12
Show InChI InChI=1S/C22H30N5O/c1-25-11-10-22(20-6-4-5-7-21(20)25)28-15-17-14-23-24-26(17)16-12-18-8-9-19(13-16)27(18,2)3/h4-7,10,14,16,18-19H,8-9,11-13,15H2,1-3H3/q+1
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2 -48.8n/an/an/an/an/a7.420



University of California San Diego



Assay Description
Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 ?l of 0.2 mg/ml an...


Mol Pharmacol 82: 687-699 (2014)


Article DOI: 10.1124/mol.112.080291
BindingDB Entry DOI: 10.7270/Q2805163
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM92377
PNG
(NS3573, 2)
Show SMILES CCOc1cncc(c1)N1CCCNCC1
Show InChI InChI=1S/C12H19N3O/c1-2-16-12-8-11(9-14-10-12)15-6-3-4-13-5-7-15/h8-10,13H,2-7H2,1H3
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2.20n/an/an/an/an/an/an/an/a



University of Copenhagen



Assay Description
Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...


J Biol Chem 287: 4248-59 (2012)


Article DOI: 10.1074/jbc.M111.292243
BindingDB Entry DOI: 10.7270/Q2J964Z5
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50520723
PNG
(CHEMBL4440256)
Show SMILES Clc1ccc(CC2(COc3cccnc3)CCCNC2)cc1Cl
Show InChI InChI=1S/C18H20Cl2N2O/c19-16-5-4-14(9-17(16)20)10-18(6-2-8-22-12-18)13-23-15-3-1-7-21-11-15/h1,3-5,7,9,11,22H,2,6,8,10,12-13H2
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2.30n/an/an/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein incubated for 60 mins followed by 3 hrs incubation in dark condi...


Eur J Med Chem 160: 37-48 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.073
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Aplysia Californica)
BDBM50080818
PNG
((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
Show SMILES CN1[C@H](C[C@H](O)c2ccccc2)CCC[C@@H]1CC(=O)c1ccccc1
Show InChI InChI=1S/C22H27NO2/c1-23-19(15-21(24)17-9-4-2-5-10-17)13-8-14-20(23)16-22(25)18-11-6-3-7-12-18/h2-7,9-12,19-21,24H,8,13-16H2,1H3/t19-,20+,21-/m0/s1
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2.51n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from Aplysia californica acetylcholine binding protein expressed using baculoviral system after 1.5 hrs by scintillat...


Bioorg Med Chem Lett 22: 1448-54 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.008
BindingDB Entry DOI: 10.7270/Q26Q1ZHD
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50088438
PNG
(1-(pyridin-3-yl)-1,4-diazepane | 1-Pyridin-3-yl-[1...)
Show SMILES C1CNCCN(C1)c1cccnc1
Show InChI InChI=1S/C10H15N3/c1-3-10(9-12-4-1)13-7-2-5-11-6-8-13/h1,3-4,9,11H,2,5-8H2
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3.10n/an/an/an/an/an/an/an/a



University of Copenhagen



Assay Description
Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...


J Biol Chem 287: 4248-59 (2012)


Article DOI: 10.1074/jbc.M111.292243
BindingDB Entry DOI: 10.7270/Q2J964Z5
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50520715
PNG
(CHEMBL4437999)
Show SMILES Clc1cccc(CC2(COc3ccc(Cl)nc3)CCCNC2)c1
Show InChI InChI=1S/C18H20Cl2N2O/c19-15-4-1-3-14(9-15)10-18(7-2-8-21-12-18)13-23-16-5-6-17(20)22-11-16/h1,3-6,9,11,21H,2,7-8,10,12-13H2
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3.40n/an/an/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein incubated for 60 mins followed by 3 hrs incubation in dark condi...


Eur J Med Chem 160: 37-48 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.073
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50520705
PNG
(CHEMBL4458658)
Show SMILES OCCCCC#Cc1cncc(OCC2(Cc3cccc(Cl)c3)CCCNC2)c1
Show InChI InChI=1S/C24H29ClN2O2/c25-22-9-5-8-20(13-22)15-24(10-6-11-26-18-24)19-29-23-14-21(16-27-17-23)7-3-1-2-4-12-28/h5,8-9,13-14,16-17,26,28H,1-2,4,6,10-12,15,18-19H2
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3.5n/an/an/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein incubated for 60 mins followed by 3 hrs incubation in dark condi...


Eur J Med Chem 160: 37-48 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.073
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Aplysia Californica)
BDBM50251868
PNG
((Z)-thiacloprid | CHEMBL451432 | {(2Z)-3-[(6-chlor...)
Show SMILES Clc1ccc(CN2CCS\C2=N/C#N)cn1
Show InChI InChI=1S/C10H9ClN4S/c11-9-2-1-8(5-13-9)6-15-3-4-16-10(15)14-7-12/h1-2,5H,3-4,6H2/b14-10-
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3.90n/an/an/an/an/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Binding affinity to salt water mollusc Aplysia californica AChBP Y55W mutant assessed as [3H]acetamiprid binding by radioligand binding assay


J Agric Food Chem 59: 2825-8 (2011)


Article DOI: 10.1021/jf1019455
BindingDB Entry DOI: 10.7270/Q2GF0XCJ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM91615
PNG
(15q | alpha7 agonists 15q)
Show SMILES C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](C2)n1cc(CSc2nc3ccccc3s2)nn1
Show InChI InChI=1S/C19H24N5S2/c1-24(2)15-7-8-16(24)10-14(9-15)23-11-13(21-22-23)12-25-19-20-17-5-3-4-6-18(17)26-19/h3-6,11,14-16H,7-10,12H2,1-2H3/q+1/t14-,15-,16+
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4 -47.1n/an/an/an/an/a7.420



University of California San Diego



Assay Description
Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 ?l of 0.2 mg/ml an...


Mol Pharmacol 82: 687-699 (2014)


Article DOI: 10.1124/mol.112.080291
BindingDB Entry DOI: 10.7270/Q2805163
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50520710
PNG
(CHEMBL4551353)
Show SMILES Clc1cccc(CC2(COc3cncnc3)CCCNC2)c1
Show InChI InChI=1S/C17H20ClN3O/c18-15-4-1-3-14(7-15)8-17(5-2-6-19-11-17)12-22-16-9-20-13-21-10-16/h1,3-4,7,9-10,13,19H,2,5-6,8,11-12H2
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5.20n/an/an/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein incubated for 60 mins followed by 3 hrs incubation in dark condi...


Eur J Med Chem 160: 37-48 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.073
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50520720
PNG
(CHEMBL4557873)
Show SMILES Clc1cccc(CC2(COc3cccnc3)CCCNC2)c1
Show InChI InChI=1S/C18H21ClN2O/c19-16-5-1-4-15(10-16)11-18(7-3-9-21-13-18)14-22-17-6-2-8-20-12-17/h1-2,4-6,8,10,12,21H,3,7,9,11,13-14H2
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5.30n/an/an/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein incubated for 60 mins followed by 3 hrs incubation in dark condi...


Eur J Med Chem 160: 37-48 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.073
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50520729
PNG
(CHEMBL4541936)
Show SMILES OCCC#Cc1cncc(OCC2(Cc3cccc(Cl)c3)CCCNC2)c1
Show InChI InChI=1S/C22H25ClN2O2/c23-20-7-3-6-18(11-20)13-22(8-4-9-24-16-22)17-27-21-12-19(14-25-15-21)5-1-2-10-26/h3,6-7,11-12,14-15,24,26H,2,4,8-10,13,16-17H2
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5.60n/an/an/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein incubated for 60 mins followed by 3 hrs incubation in dark condi...


Eur J Med Chem 160: 37-48 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.073
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50520732
PNG
(CHEMBL4444365)
Show SMILES FC(F)(F)c1cccc(CC2(COc3cccnc3)CCCNC2)c1
Show InChI InChI=1S/C19H21F3N2O/c20-19(21,22)16-5-1-4-15(10-16)11-18(7-3-9-24-13-18)14-25-17-6-2-8-23-12-17/h1-2,4-6,8,10,12,24H,3,7,9,11,13-14H2
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5.90n/an/an/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein incubated for 60 mins followed by 3 hrs incubation in dark condi...


Eur J Med Chem 160: 37-48 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.073
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50520716
PNG
(CHEMBL4467323)
Show SMILES Clc1cccc(CC2(COc3cccnc3)CCCNC2)c1Cl
Show InChI InChI=1S/C18H20Cl2N2O/c19-16-6-1-4-14(17(16)20)10-18(7-3-9-22-12-18)13-23-15-5-2-8-21-11-15/h1-2,4-6,8,11,22H,3,7,9-10,12-13H2
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6n/an/an/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein incubated for 60 mins followed by 3 hrs incubation in dark condi...


Eur J Med Chem 160: 37-48 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.073
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Aplysia Californica)
BDBM50143314
PNG
((+)-Epibatidine | (-)-epibatidine | (1R,2R,4S)-2-(...)
Show SMILES Clc1ccc(cn1)[C@H]1C[C@@H]2CC[C@H]1N2
Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2/t8-,9+,10+/m0/s1
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7.40 -45.6n/an/an/an/an/a7.420



UC San Diego



Assay Description
Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 ul of 0.2 mg/ml an...


Taylor Research Group (2014)


BindingDB Entry DOI: 10.7270/Q2DR2T3Z
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Acetylcholine Binding protein


(Aplysia Californica)
BDBM91615
PNG
(15q | alpha7 agonists 15q)
Show SMILES C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](C2)n1cc(CSc2nc3ccccc3s2)nn1
Show InChI InChI=1S/C19H24N5S2/c1-24(2)15-7-8-16(24)10-14(9-15)23-11-13(21-22-23)12-25-19-20-17-5-3-4-6-18(17)26-19/h3-6,11,14-16H,7-10,12H2,1-2H3/q+1/t14-,15-,16+
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8 -45.4n/an/an/an/an/a7.420



University of California San Diego



Assay Description
Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 ?l of 0.2 mg/ml an...


Mol Pharmacol 82: 687-699 (2014)


Article DOI: 10.1124/mol.112.080291
BindingDB Entry DOI: 10.7270/Q2805163
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM86311
PNG
(CAS_485-35-8 | Cytisine | Cytisine-(-) | NSC_22407)
Show SMILES O=c1cccc2C3CNCC(C3)Cn12
Show InChI InChI=1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2
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8.20n/an/an/an/an/an/an/an/a



University of Copenhagen



Assay Description
Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...


J Biol Chem 287: 4248-59 (2012)


Article DOI: 10.1074/jbc.M111.292243
BindingDB Entry DOI: 10.7270/Q2J964Z5
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50088437
PNG
(1-(5-Phenyl-pyridin-3-yl)-[1,4]diazepane | CHEMBL3...)
Show SMILES C1CNCCN(C1)c1cncc(c1)-c1ccccc1
Show InChI InChI=1S/C16H19N3/c1-2-5-14(6-3-1)15-11-16(13-18-12-15)19-9-4-7-17-8-10-19/h1-3,5-6,11-13,17H,4,7-10H2
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8.90n/an/an/an/an/an/an/an/a



University of Copenhagen



Assay Description
Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...


J Biol Chem 287: 4248-59 (2012)


Article DOI: 10.1074/jbc.M111.292243
BindingDB Entry DOI: 10.7270/Q2J964Z5
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50520718
PNG
(CHEMBL4447538)
Show SMILES Clc1ccc(CC2(COc3cccnc3)CCCNC2)cc1
Show InChI InChI=1S/C18H21ClN2O/c19-16-6-4-15(5-7-16)11-18(8-2-10-21-13-18)14-22-17-3-1-9-20-12-17/h1,3-7,9,12,21H,2,8,10-11,13-14H2
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9.80n/an/an/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein incubated for 60 mins followed by 3 hrs incubation in dark condi...


Eur J Med Chem 160: 37-48 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.073
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50520727
PNG
(CHEMBL4537917)
Show SMILES Clc1cccc(CC2(COc3ccc(Br)nc3)CCCNC2)c1
Show InChI InChI=1S/C18H20BrClN2O/c19-17-6-5-16(11-22-17)23-13-18(7-2-8-21-12-18)10-14-3-1-4-15(20)9-14/h1,3-6,9,11,21H,2,7-8,10,12-13H2
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11n/an/an/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein incubated for 60 mins followed by 3 hrs incubation in dark condi...


Eur J Med Chem 160: 37-48 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.073
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50520712
PNG
(CHEMBL4556242)
Show SMILES OCCCC#Cc1cncc(OCC2(Cc3cccc(Cl)c3)CCCNC2)c1
Show InChI InChI=1S/C23H27ClN2O2/c24-21-8-4-7-19(12-21)14-23(9-5-10-25-17-23)18-28-22-13-20(15-26-16-22)6-2-1-3-11-27/h4,7-8,12-13,15-16,25,27H,1,3,5,9-11,14,17-18H2
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12n/an/an/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein incubated for 60 mins followed by 3 hrs incubation in dark condi...


Eur J Med Chem 160: 37-48 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.073
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50520719
PNG
(CHEMBL4452235)
Show SMILES Cc1cccc(CC2(COc3cccnc3)CCCNC2)c1
Show InChI InChI=1S/C19H24N2O/c1-16-5-2-6-17(11-16)12-19(8-4-10-21-14-19)15-22-18-7-3-9-20-13-18/h2-3,5-7,9,11,13,21H,4,8,10,12,14-15H2,1H3
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12n/an/an/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein incubated for 60 mins followed by 3 hrs incubation in dark condi...


Eur J Med Chem 160: 37-48 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.073
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50520706
PNG
(CHEMBL4437423)
Show SMILES C(Oc1cccnc1)C1(Cc2ccc(cc2)-c2ccccc2)CCCNC1
Show InChI InChI=1S/C24H26N2O/c1-2-6-21(7-3-1)22-11-9-20(10-12-22)16-24(13-5-15-26-18-24)19-27-23-8-4-14-25-17-23/h1-4,6-12,14,17,26H,5,13,15-16,18-19H2
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12n/an/an/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein incubated for 60 mins followed by 3 hrs incubation in dark condi...


Eur J Med Chem 160: 37-48 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.073
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50520731
PNG
(CHEMBL4558905)
Show SMILES FC(F)(F)c1ccc(CC2(COc3cccnc3)CCCNC2)cc1
Show InChI InChI=1S/C19H21F3N2O/c20-19(21,22)16-6-4-15(5-7-16)11-18(8-2-10-24-13-18)14-25-17-3-1-9-23-12-17/h1,3-7,9,12,24H,2,8,10-11,13-14H2
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12n/an/an/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein incubated for 60 mins followed by 3 hrs incubation in dark condi...


Eur J Med Chem 160: 37-48 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.073
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50382466
PNG
(CHEMBL2024087)
Show SMILES OCC[C@H]1C[C@@H]1c1cncc(OC[C@@H]2CCN2)c1
Show InChI InChI=1S/C14H20N2O2/c17-4-2-10-6-14(10)11-5-13(8-15-7-11)18-9-12-1-3-16-12/h5,7-8,10,12,14,16-17H,1-4,6,9H2/t10-,12-,14-/m0/s1
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12.8n/an/an/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from Lymnaea stagnalis AChBP


J Med Chem 55: 8028-37 (2012)


Article DOI: 10.1021/jm3008739
BindingDB Entry DOI: 10.7270/Q2NC62BW
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50520728
PNG
(CHEMBL4447431)
Show SMILES Clc1ccccc1CC1(COc2cccnc2)CCCNC1
Show InChI InChI=1S/C18H21ClN2O/c19-17-7-2-1-5-15(17)11-18(8-4-10-21-13-18)14-22-16-6-3-9-20-12-16/h1-3,5-7,9,12,21H,4,8,10-11,13-14H2
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13n/an/an/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein incubated for 60 mins followed by 3 hrs incubation in dark condi...


Eur J Med Chem 160: 37-48 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.073
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Aplysia Californica)
BDBM91615
PNG
(15q | alpha7 agonists 15q)
Show SMILES C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](C2)n1cc(CSc2nc3ccccc3s2)nn1
Show InChI InChI=1S/C19H24N5S2/c1-24(2)15-7-8-16(24)10-14(9-15)23-11-13(21-22-23)12-25-19-20-17-5-3-4-6-18(17)26-19/h3-6,11,14-16H,7-10,12H2,1-2H3/q+1/t14-,15-,16+
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13 -44.3n/an/an/an/an/a7.420



University of California San Diego



Assay Description
Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 ?l of 0.2 mg/ml an...


Mol Pharmacol 82: 687-699 (2014)


Article DOI: 10.1124/mol.112.080291
BindingDB Entry DOI: 10.7270/Q2805163
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Aplysia Californica)
BDBM91615
PNG
(15q | alpha7 agonists 15q)
Show SMILES C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](C2)n1cc(CSc2nc3ccccc3s2)nn1
Show InChI InChI=1S/C19H24N5S2/c1-24(2)15-7-8-16(24)10-14(9-15)23-11-13(21-22-23)12-25-19-20-17-5-3-4-6-18(17)26-19/h3-6,11,14-16H,7-10,12H2,1-2H3/q+1/t14-,15-,16+
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13 -44.3n/an/an/an/an/a7.420



University of California San Diego



Assay Description
Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 ?l of 0.2 mg/ml an...


Mol Pharmacol 82: 687-699 (2014)


Article DOI: 10.1124/mol.112.080291
BindingDB Entry DOI: 10.7270/Q2805163
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50393247
PNG
(CHEMBL1258006)
Show SMILES O=C(N[C@@H]1C2CCN(CC2)[C@H]1Cc1cccnc1)c1cc2ccccc2o1
Show InChI InChI=1S/C22H23N3O2/c26-22(20-13-17-5-1-2-6-19(17)27-20)24-21-16-7-10-25(11-8-16)18(21)12-15-4-3-9-23-14-15/h1-6,9,13-14,16,18,21H,7-8,10-12H2,(H,24,26)/t18-,21+/m0/s1
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14.4n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from Lymnaea stagnalis His6-AChBP expressed in Bac-to-Bac baculovirus expression system


J Med Chem 53: 7192-201 (2010)


Article DOI: 10.1021/jm100834y
BindingDB Entry DOI: 10.7270/Q21J9C1V
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Aplysia Californica)
BDBM50078048
PNG
(1-(6-Chloro-pyridin-3-ylmethyl)-imidazolidin-(2Z)-...)
Show SMILES NC1=NCCN1Cc1ccc(Cl)nc1
Show InChI InChI=1S/C9H11ClN4/c10-8-2-1-7(5-13-8)6-14-4-3-12-9(14)11/h1-2,5H,3-4,6H2,(H2,11,12)
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15n/an/an/an/an/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Binding affinity to salt water mollusc Aplysia californica AChBP Y55W mutant assessed as [3H]acetamiprid binding by radioligand binding assay


J Agric Food Chem 59: 2825-8 (2011)


Article DOI: 10.1021/jf1019455
BindingDB Entry DOI: 10.7270/Q2GF0XCJ
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50520713
PNG
(CHEMBL4444981)
Show SMILES OCCCCC#Cc1ccc(OCC2(Cc3cccc(Cl)c3)CCCNC2)cn1
Show InChI InChI=1S/C24H29ClN2O2/c25-21-8-5-7-20(15-21)16-24(12-6-13-26-18-24)19-29-23-11-10-22(27-17-23)9-3-1-2-4-14-28/h5,7-8,10-11,15,17,26,28H,1-2,4,6,12-14,16,18-19H2
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16n/an/an/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein incubated for 60 mins followed by 3 hrs incubation in dark condi...


Eur J Med Chem 160: 37-48 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.073
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50472282
PNG
(DESCYANOTHIACLOPRID | descyanothiacloprid)
Show SMILES Clc1ccc(CN2CCSC2=N)cn1
Show InChI InChI=1S/C9H10ClN3S/c10-8-2-1-7(5-12-8)6-13-3-4-14-9(13)11/h1-2,5,11H,3-4,6H2
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16n/an/an/an/an/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Binding affinity to freshwater snail Lymnaea stagnalis AChBP assessed as [3H]EPI binding by radioligand binding assay


J Agric Food Chem 59: 2825-8 (2011)


Article DOI: 10.1021/jf1019455
BindingDB Entry DOI: 10.7270/Q2GF0XCJ
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Aplysia Californica)
BDBM91624
PNG
(alpha7 agonists 4t)
Show SMILES CN1[C@H]2CC[C@@H]1C[C@H](C2)n1cc(COc2cc(=O)n(C)c3ccccc23)nn1
Show InChI InChI=1S/C21H25N5O2/c1-24-15-7-8-16(24)10-17(9-15)26-12-14(22-23-26)13-28-20-11-21(27)25(2)19-6-4-3-5-18(19)20/h3-6,11-12,15-17H,7-10,13H2,1-2H3/t15-,16+,17-
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16 -43.8n/an/an/an/an/a7.420



University of California San Diego



Assay Description
Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 ?l of 0.2 mg/ml an...


Mol Pharmacol 82: 687-699 (2014)


Article DOI: 10.1124/mol.112.080291
BindingDB Entry DOI: 10.7270/Q2805163
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50520717
PNG
(CHEMBL4540765)
Show SMILES Cc1ccc(CC2(COc3cccnc3)CCCNC2)cc1
Show InChI InChI=1S/C19H24N2O/c1-16-5-7-17(8-6-16)12-19(9-3-11-21-14-19)15-22-18-4-2-10-20-13-18/h2,4-8,10,13,21H,3,9,11-12,14-15H2,1H3
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16n/an/an/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein incubated for 60 mins followed by 3 hrs incubation in dark condi...


Eur J Med Chem 160: 37-48 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.073
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50520707
PNG
(CHEMBL4451952)
Show SMILES FC(F)(F)c1ccccc1CC1(COc2cccnc2)CCCNC1
Show InChI InChI=1S/C19H21F3N2O/c20-19(21,22)17-7-2-1-5-15(17)11-18(8-4-10-24-13-18)14-25-16-6-3-9-23-12-16/h1-3,5-7,9,12,24H,4,8,10-11,13-14H2
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17n/an/an/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein incubated for 60 mins followed by 3 hrs incubation in dark condi...


Eur J Med Chem 160: 37-48 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.073
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50520711
PNG
(CHEMBL4579917)
Show SMILES Clc1cccc(CC2(COc3ccncc3)CCCNC2)c1
Show InChI InChI=1S/C18H21ClN2O/c19-16-4-1-3-15(11-16)12-18(7-2-8-21-13-18)14-22-17-5-9-20-10-6-17/h1,3-6,9-11,21H,2,7-8,12-14H2
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17n/an/an/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein incubated for 60 mins followed by 3 hrs incubation in dark condi...


Eur J Med Chem 160: 37-48 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.073
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Aplysia Californica)
BDBM91621
PNG
(21q | alpha7 agonists 21q)
Show SMILES Cc1cc(C)nc(SCCCc2cn(nn2)[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)n1
Show InChI InChI=1S/C20H31N6S/c1-14-10-15(2)22-20(21-14)27-9-5-6-16-13-25(24-23-16)17-11-18-7-8-19(12-17)26(18,3)4/h10,13,17-19H,5-9,11-12H2,1-4H3/q+1/t17-,18-,19+
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18 -43.5n/an/an/an/an/a7.420



University of California San Diego



Assay Description
Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 ?l of 0.2 mg/ml an...


Mol Pharmacol 82: 687-699 (2014)


Article DOI: 10.1124/mol.112.080291
BindingDB Entry DOI: 10.7270/Q2805163
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50078048
PNG
(1-(6-Chloro-pyridin-3-ylmethyl)-imidazolidin-(2Z)-...)
Show SMILES NC1=NCCN1Cc1ccc(Cl)nc1
Show InChI InChI=1S/C9H11ClN4/c10-8-2-1-7(5-13-8)6-14-4-3-12-9(14)11/h1-2,5H,3-4,6H2,(H2,11,12)
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18n/an/an/an/an/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Binding affinity to freshwater snail Lymnaea stagnalis AChBP assessed as [3H]EPI binding by radioligand binding assay


J Agric Food Chem 59: 2825-8 (2011)


Article DOI: 10.1021/jf1019455
BindingDB Entry DOI: 10.7270/Q2GF0XCJ
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50417105
PNG
(CHEMBL1258240)
Show SMILES Brc1ccc(NC(=O)O[C@@H]2C3CCN(CC3)[C@H]2Cc2cccnc2)cc1
Show InChI InChI=1S/C20H22BrN3O2/c21-16-3-5-17(6-4-16)23-20(25)26-19-15-7-10-24(11-8-15)18(19)12-14-2-1-9-22-13-14/h1-6,9,13,15,18-19H,7-8,10-12H2,(H,23,25)/t18-,19+/m0/s1
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18.2n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from Lymnaea stagnalis His6-AChBP expressed in Bac-to-Bac baculovirus expression system


J Med Chem 53: 7192-201 (2010)


Article DOI: 10.1021/jm100834y
BindingDB Entry DOI: 10.7270/Q21J9C1V
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Aplysia Californica)
BDBM50212288
PNG
((2E)-1-[(6-chloropyridin-3-yl)methyl]-N-nitroimida...)
Show SMILES [O-][N+](=O)NC1=NCCN1Cc1ccc(Cl)nc1
Show InChI InChI=1S/C9H10ClN5O2/c10-8-2-1-7(5-12-8)6-14-4-3-11-9(14)13-15(16)17/h1-2,5H,3-4,6H2,(H,11,13)
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19n/an/an/an/an/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Binding affinity to salt water mollusc Aplysia californica AChBP Y55W mutant assessed as [3H]acetamiprid binding by radioligand binding assay


J Agric Food Chem 59: 2825-8 (2011)


Article DOI: 10.1021/jf1019455
BindingDB Entry DOI: 10.7270/Q2GF0XCJ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50520721
PNG
(CHEMBL4448437)
Show SMILES Cc1ccccc1CC1(COc2cccnc2)CCCNC1
Show InChI InChI=1S/C19H24N2O/c1-16-6-2-3-7-17(16)12-19(9-5-11-21-14-19)15-22-18-8-4-10-20-13-18/h2-4,6-8,10,13,21H,5,9,11-12,14-15H2,1H3
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19n/an/an/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein incubated for 60 mins followed by 3 hrs incubation in dark condi...


Eur J Med Chem 160: 37-48 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.073
More data for this
Ligand-Target Pair
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