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Compile Data Set for Download or QSAR

Found 2138 hits Enz. Inhib. hit(s) with Target = 'Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50490821
PNG
(2-Fluoroethyl 4-Nitrophenyl Ethylphosphonate | CHE...)
Show SMILES CCP(=O)(OCCF)Oc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C10H13FNO5P/c1-2-18(15,16-8-7-11)17-10-5-3-9(4-6-10)12(13)14/h3-6H,2,7-8H2,1H3
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1.20n/an/an/an/an/an/an/an/a



The University of Montana

Curated by ChEMBL


Assay Description
Inhibition of rat brain AChE by concentration-dependent inhibition assay


Bioorg Med Chem Lett 23: 2048-51 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.010
BindingDB Entry DOI: 10.7270/Q2VH5RSV
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50240416
PNG
(CHEMBL23838 | O,O-diethyl O-p-nitrophenyl phosphat...)
Show SMILES CCOP(=O)(OCC)Oc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C10H14NO6P/c1-3-15-18(14,16-4-2)17-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3
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1.60n/an/an/an/an/an/an/an/a



The University of Montana

Curated by ChEMBL


Assay Description
Inhibition of rat brain AChE by concentration-dependent inhibition assay


Bioorg Med Chem Lett 23: 2048-51 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.010
BindingDB Entry DOI: 10.7270/Q2VH5RSV
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50240416
PNG
(CHEMBL23838 | O,O-diethyl O-p-nitrophenyl phosphat...)
Show SMILES CCOP(=O)(OCC)Oc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C10H14NO6P/c1-3-15-18(14,16-4-2)17-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3
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3.40n/an/an/an/an/an/an/an/a



The University of Montana

Curated by ChEMBL


Assay Description
Inhibition of rat brain AChE by time-dependent inhibition assay


Bioorg Med Chem Lett 23: 2048-51 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.010
BindingDB Entry DOI: 10.7270/Q2VH5RSV
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50490821
PNG
(2-Fluoroethyl 4-Nitrophenyl Ethylphosphonate | CHE...)
Show SMILES CCP(=O)(OCCF)Oc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C10H13FNO5P/c1-2-18(15,16-8-7-11)17-10-5-3-9(4-6-10)12(13)14/h3-6H,2,7-8H2,1H3
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3.80n/an/an/an/an/an/an/an/a



The University of Montana

Curated by ChEMBL


Assay Description
Inhibition of rat brain AChE by time-dependent inhibition assay


Bioorg Med Chem Lett 23: 2048-51 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.010
BindingDB Entry DOI: 10.7270/Q2VH5RSV
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50490822
PNG
(2-Fluoroethyl 4-Nitrophenyl Methylphosphonate | CH...)
Show SMILES CP(=O)(OCCF)Oc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C9H11FNO5P/c1-17(14,15-7-6-10)16-9-4-2-8(3-5-9)11(12)13/h2-5H,6-7H2,1H3
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6.10n/an/an/an/an/an/an/an/a



The University of Montana

Curated by ChEMBL


Assay Description
Inhibition of rat brain AChE by concentration-dependent inhibition assay


Bioorg Med Chem Lett 23: 2048-51 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.010
BindingDB Entry DOI: 10.7270/Q2VH5RSV
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50490822
PNG
(2-Fluoroethyl 4-Nitrophenyl Methylphosphonate | CH...)
Show SMILES CP(=O)(OCCF)Oc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C9H11FNO5P/c1-17(14,15-7-6-10)16-9-4-2-8(3-5-9)11(12)13/h2-5H,6-7H2,1H3
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6.20n/an/an/an/an/an/an/an/a



The University of Montana

Curated by ChEMBL


Assay Description
Inhibition of rat brain AChE by time-dependent inhibition assay


Bioorg Med Chem Lett 23: 2048-51 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.010
BindingDB Entry DOI: 10.7270/Q2VH5RSV
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM10440
PNG
((5S)-5-[(12-{[(5S)-2-oxo-1,2,5,6,7,8-hexahydroquin...)
Show SMILES O=c1ccc2[C@H](CCCc2[nH]1)NCCCCCCCCCCCCN[C@H]1CCCc2[nH]c(=O)ccc12
Show InChI InChI=1S/C30H46N4O2/c35-29-19-17-23-25(13-11-15-27(23)33-29)31-21-9-7-5-3-1-2-4-6-8-10-22-32-26-14-12-16-28-24(26)18-20-30(36)34-28/h17-20,25-26,31-32H,1-16,21-22H2,(H,33,35)(H,34,36)/t25-,26-/m0/s1
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19.6 -43.6 52n/an/an/an/a7.022



Weizmann Institute of Science



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at ...


J Am Chem Soc 125: 363-73 (2003)


Article DOI: 10.1021/ja021111w
BindingDB Entry DOI: 10.7270/Q26D5R69
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM10440
PNG
((5S)-5-[(12-{[(5S)-2-oxo-1,2,5,6,7,8-hexahydroquin...)
Show SMILES O=c1ccc2[C@H](CCCc2[nH]1)NCCCCCCCCCCCCN[C@H]1CCCc2[nH]c(=O)ccc12
Show InChI InChI=1S/C30H46N4O2/c35-29-19-17-23-25(13-11-15-27(23)33-29)31-21-9-7-5-3-1-2-4-6-8-10-22-32-26-14-12-16-28-24(26)18-20-30(36)34-28/h17-20,25-26,31-32H,1-16,21-22H2,(H,33,35)(H,34,36)/t25-,26-/m0/s1
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20n/an/an/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
Inhibition of rat AChE


J Med Chem 51: 3154-70 (2008)


Article DOI: 10.1021/jm701253t
BindingDB Entry DOI: 10.7270/Q22Z16D4
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50342601
PNG
(CHEMBL1255901 | Huperzine A)
Show SMILES C\C=C1/[C@@H]2Cc3[nH]c(=O)ccc3[C@]1(N)CC(C)=C2
Show InChI InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10-,15-/m0/s1
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24n/an/an/an/an/an/an/an/a



Universit£t Wien

Curated by ChEMBL


Assay Description
Compound was tested for its ability to inhibit acetylcholinesterase (AChE) in rat brain; 0.024-0.040 uM


Bioorg Med Chem Lett 11: 2627-30 (2001)


Article DOI: 10.1016/s0960-894x(01)00518-2
BindingDB Entry DOI: 10.7270/Q2VH5PCN
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM10441
PNG
((+)-Huperzine A | (+/-)Huperzine A | (-)-Huperzine...)
Show SMILES C\C=C1/C2Cc3[nH]c(=O)ccc3C1(N)CC(C)=C2
Show InChI InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+
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47.1 -41.4 114n/an/an/an/a7.022



Weizmann Institute of Science



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at ...


J Am Chem Soc 125: 363-73 (2003)


Article DOI: 10.1021/ja021111w
BindingDB Entry DOI: 10.7270/Q26D5R69
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50429847
PNG
(CHEMBL2338670)
Show SMILES Oc1cccc2C(=O)c3cc(C[n+]4ccccc4)cc(O)c3C(=O)c12
Show InChI InChI=1S/C20H13NO4/c22-15-6-4-5-13-17(15)20(25)18-14(19(13)24)9-12(10-16(18)23)11-21-7-2-1-3-8-21/h1-10H,11H2,(H-,22,23,25)/p+1
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279n/an/an/an/an/an/an/an/a



Hainan University

Curated by ChEMBL


Assay Description
Inhibition of AChE in rat cortex using acetylthiocholine iodide as substrate by double Lineweaver-Burk plot analysis


Bioorg Med Chem 21: 1064-73 (2013)


Article DOI: 10.1016/j.bmc.2013.01.015
BindingDB Entry DOI: 10.7270/Q2GB25C5
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50104605
PNG
(13-Eth-(E)-ylidene-11-methyl-6-aza-tricyclo[7.3.1....)
Show SMILES C\C=C1/C2Cc3[nH]c(=O)ccc3C1CC(C)=C2
Show InChI InChI=1S/C15H17NO/c1-3-11-10-6-9(2)7-13(11)12-4-5-15(17)16-14(12)8-10/h3-6,10,13H,7-8H2,1-2H3,(H,16,17)/b11-3+
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2.00E+3n/an/an/an/an/an/an/an/a



Universit£t Wien

Curated by ChEMBL


Assay Description
Compound was tested for its ability to inhibit acetylcholinesterase (AChE) in rat brain


Bioorg Med Chem Lett 11: 2627-30 (2001)


Article DOI: 10.1016/s0960-894x(01)00518-2
BindingDB Entry DOI: 10.7270/Q2VH5PCN
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50026058
PNG
(CHEMBL3335259)
Show SMILES COc1cc(OC)c(C(=O)\C=C\c2ccccc2)c(O)c1CN1CCCCC1
Show InChI InChI=1S/C23H27NO4/c1-27-20-15-21(28-2)22(19(25)12-11-17-9-5-3-6-10-17)23(26)18(20)16-24-13-7-4-8-14-24/h3,5-6,9-12,15,26H,4,7-8,13-14,16H2,1-2H3/b12-11+
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2.75E+3n/an/an/an/an/an/an/an/a



Hunan University

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat brain AChE by Michaelis-Menten equation


Bioorg Med Chem Lett 24: 4749-53 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.087
BindingDB Entry DOI: 10.7270/Q2PR7XKV
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50026058
PNG
(CHEMBL3335259)
Show SMILES COc1cc(OC)c(C(=O)\C=C\c2ccccc2)c(O)c1CN1CCCCC1
Show InChI InChI=1S/C23H27NO4/c1-27-20-15-21(28-2)22(19(25)12-11-17-9-5-3-6-10-17)23(26)18(20)16-24-13-7-4-8-14-24/h3,5-6,9-12,15,26H,4,7-8,13-14,16H2,1-2H3/b12-11+
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4.58E+3n/an/an/an/an/an/an/an/a



Hunan University

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat brain AChE using acetylthiocholin iodide as substrate by Michaelis-Menten equation


Bioorg Med Chem Lett 24: 4749-53 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.087
BindingDB Entry DOI: 10.7270/Q2PR7XKV
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50133817
PNG
(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)
Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2Cl)cc1
Show InChI InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)
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>1.00E+4n/an/an/an/an/an/an/an/a



Pudue Pharma Discovery Research

Curated by PDSP Ki Database




J Pharmacol Exp Ther 306: 377-86 (2003)


Article DOI: 10.1124/jpet.102.045674
BindingDB Entry DOI: 10.7270/Q2TX3CX5
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50104603
PNG
(13-Eth-(Z)-ylidene-11-methyl-6-aza-tricyclo[7.3.1....)
Show SMILES C\C=C1\C2Cc3[nH]c(=O)ccc3C1CC(C)=C2
Show InChI InChI=1S/C15H17NO/c1-3-11-10-6-9(2)7-13(11)12-4-5-15(17)16-14(12)8-10/h3-6,10,13H,7-8H2,1-2H3,(H,16,17)/b11-3-
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1.23E+4n/an/an/an/an/an/an/an/a



Universit£t Wien

Curated by ChEMBL


Assay Description
Compound was tested for its ability to inhibit acetylcholinesterase (AChE) in rat brain


Bioorg Med Chem Lett 11: 2627-30 (2001)


Article DOI: 10.1016/s0960-894x(01)00518-2
BindingDB Entry DOI: 10.7270/Q2VH5PCN
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50028409
PNG
(CHEMBL285508 | Trimethyl-[3-(2-oxo-2lambda*5*-[1,3...)
Show SMILES C[N+](C)(C)c1cccc(OP2(=O)OCCCO2)c1
Show InChI InChI=1S/C12H19NO4P/c1-13(2,3)11-6-4-7-12(10-11)17-18(14)15-8-5-9-16-18/h4,6-7,10H,5,8-9H2,1-3H3/q+1
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3.10E+4n/an/an/an/an/an/a7.0n/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory constant of the compound against rat brain acetylcholinesterase at pH 7.0


J Med Chem 26: 145-52 (1983)


Article DOI: 10.1021/jm00356a006
BindingDB Entry DOI: 10.7270/Q23T9G75
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50104604
PNG
(11-Methyl-6-aza-tricyclo[7.3.1.0*2,7*]trideca-2(7)...)
Show SMILES CC1=CC2Cc3[nH]c(=O)ccc3C(C1)C2=O
Show InChI InChI=1S/C13H13NO2/c1-7-4-8-6-11-9(2-3-12(15)14-11)10(5-7)13(8)16/h2-4,8,10H,5-6H2,1H3,(H,14,15)
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>5.00E+5n/an/an/an/an/an/an/an/a



Universit£t Wien

Curated by ChEMBL


Assay Description
Compound was tested for its ability to inhibit acetylcholinesterase (AChE) in rat brain


Bioorg Med Chem Lett 11: 2627-30 (2001)


Article DOI: 10.1016/s0960-894x(01)00518-2
BindingDB Entry DOI: 10.7270/Q2VH5PCN
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM8960
PNG
((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Show SMILES COc1cc2CC(CC3CCN(Cc4ccccc4)CC3)C(=O)c2cc1OC
Show InChI InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3
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n/an/a 0.0160n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman method


Citation and Details

Article DOI: 10.1007/s00044-012-0227-3
BindingDB Entry DOI: 10.7270/Q24F1TN5
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50248715
PNG
((E)-2-{4-[(Diethylamino)methyl]benzylidene}-5,6-di...)
Show SMILES CCN(CC)Cc1ccc(\C=C2/Cc3cc(OC)c(OC)cc3C2=O)cc1
Show InChI InChI=1S/C23H27NO3/c1-5-24(6-2)15-17-9-7-16(8-10-17)11-19-12-18-13-21(26-3)22(27-4)14-20(18)23(19)25/h7-11,13-14H,5-6,12,15H2,1-4H3/b19-11+
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n/an/a 0.0350n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman method


Citation and Details

Article DOI: 10.1007/s00044-012-0227-3
BindingDB Entry DOI: 10.7270/Q24F1TN5
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50248747
PNG
((E)-5,6-Dimethoxy-2-{4-[(pyrrolidin-1-yl)methyl]-b...)
Show SMILES COc1cc2C\C(=C/c3ccc(CN4CCCC4)cc3)C(=O)c2cc1OC
Show InChI InChI=1S/C23H25NO3/c1-26-21-13-18-12-19(23(25)20(18)14-22(21)27-2)11-16-5-7-17(8-6-16)15-24-9-3-4-10-24/h5-8,11,13-14H,3-4,9-10,12,15H2,1-2H3/b19-11+
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n/an/a 0.0450n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman method


Citation and Details

Article DOI: 10.1007/s00044-012-0227-3
BindingDB Entry DOI: 10.7270/Q24F1TN5
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50169850
PNG
(5,6-Dimethoxy-2-(4-pyrrolidin-1-ylmethyl-phenoxy)-...)
Show SMILES COc1cc2CC(Oc3ccc(CN4CCCC4)cc3)C(=O)c2cc1OC
Show InChI InChI=1S/C22H25NO4/c1-25-19-11-16-12-21(22(24)18(16)13-20(19)26-2)27-17-7-5-15(6-8-17)14-23-9-3-4-10-23/h5-8,11,13,21H,3-4,9-10,12,14H2,1-2H3
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n/an/a 0.0500n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman method


Citation and Details

Article DOI: 10.1007/s00044-012-0227-3
BindingDB Entry DOI: 10.7270/Q24F1TN5
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM9054
PNG
(6-chloro-N-{7-[(6-chloro-1,2,3,4-tetrahydroacridin...)
Show SMILES Clc1ccc2c(NCCCCCCCNc3c4CCCCc4nc4cc(Cl)ccc34)c3CCCCc3nc2c1
Show InChI InChI=1S/C33H38Cl2N4/c34-22-14-16-26-30(20-22)38-28-12-6-4-10-24(28)32(26)36-18-8-2-1-3-9-19-37-33-25-11-5-7-13-29(25)39-31-21-23(35)15-17-27(31)33/h14-17,20-21H,1-13,18-19H2,(H,36,38)(H,37,39)
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n/an/a 0.0700n/an/an/an/a7.437



National Defense Medical Center



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Med Chem 45: 2277-82 (2002)


Article DOI: 10.1021/jm010308g
BindingDB Entry DOI: 10.7270/Q2KW5D89
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50235322
PNG
(CHEMBL4066593)
Show SMILES Clc1ccc2c(NCCCCCCCCNc3c4CCCCc4nc4ccccc34)c3CCCCc3nc2c1
Show InChI InChI=1S/C34H41ClN4/c35-24-19-20-28-32(23-24)39-31-18-10-7-15-27(31)34(28)37-22-12-4-2-1-3-11-21-36-33-25-13-5-8-16-29(25)38-30-17-9-6-14-26(30)33/h5,8,13,16,19-20,23H,1-4,6-7,9-12,14-15,17-18,21-22H2,(H,36,38)(H,37,39)
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n/an/a 0.0700n/an/an/an/an/an/a



Tehran University of Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of rat cortex AchE using acetylthiocholine iodide as substrate by Ellman's method


Eur J Med Chem 128: 332-345 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.060
BindingDB Entry DOI: 10.7270/Q2HM5BQX
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50169857
PNG
(2-(4-Diethylaminomethyl-phenoxy)-5,6-dimethoxy-ind...)
Show SMILES CCN(CC)Cc1ccc(OC2Cc3cc(OC)c(OC)cc3C2=O)cc1
Show InChI InChI=1S/C22H27NO4/c1-5-23(6-2)14-15-7-9-17(10-8-15)27-21-12-16-11-19(25-3)20(26-4)13-18(16)22(21)24/h7-11,13,21H,5-6,12,14H2,1-4H3
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n/an/a 0.100n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman method


Citation and Details

Article DOI: 10.1007/s00044-012-0227-3
BindingDB Entry DOI: 10.7270/Q24F1TN5
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50248781
PNG
((E)-5,6-Dimethoxy-2-{4-[(piperidin-1-yl)methyl]-be...)
Show SMILES COc1cc2C\C(=C/c3ccc(CN4CCCCC4)cc3)C(=O)c2cc1OC
Show InChI InChI=1S/C24H27NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-6-8-18(9-7-17)16-25-10-4-3-5-11-25/h6-9,12,14-15H,3-5,10-11,13,16H2,1-2H3/b20-12+
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n/an/a 0.102n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman method


Citation and Details

Article DOI: 10.1007/s00044-012-0227-3
BindingDB Entry DOI: 10.7270/Q24F1TN5
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50248880
PNG
(5,6-Dimethoxy-2-{4-[(piperidin-1-yl)methyl]-benzyl...)
Show SMILES COc1cc2CC(Cc3ccc(CN4CCCCC4)cc3)C(=O)c2cc1OC
Show InChI InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-6-8-18(9-7-17)16-25-10-4-3-5-11-25/h6-9,14-15,20H,3-5,10-13,16H2,1-2H3
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n/an/a 0.124n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman method


Citation and Details

Article DOI: 10.1007/s00044-012-0227-3
BindingDB Entry DOI: 10.7270/Q24F1TN5
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50169865
PNG
(5,6-Dimethoxy-2-[4-(1-piperidin-1-yl-ethyl)-phenox...)
Show SMILES COc1cc2CC(Oc3ccc(cc3)C(C)N3CCCCC3)C(=O)c2cc1OC
Show InChI InChI=1S/C24H29NO4/c1-16(25-11-5-4-6-12-25)17-7-9-19(10-8-17)29-23-14-18-13-21(27-2)22(28-3)15-20(18)24(23)26/h7-10,13,15-16,23H,4-6,11-12,14H2,1-3H3
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n/an/a 0.130n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman method


Citation and Details

Article DOI: 10.1007/s00044-012-0227-3
BindingDB Entry DOI: 10.7270/Q24F1TN5
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50169871
PNG
(5,6-Dimethoxy-2-[4-(1-pyrrolidin-1-yl-ethyl)-pheno...)
Show SMILES COc1cc2CC(Oc3ccc(cc3)C(C)N3CCCC3)C(=O)c2cc1OC
Show InChI InChI=1S/C23H27NO4/c1-15(24-10-4-5-11-24)16-6-8-18(9-7-16)28-22-13-17-12-20(26-2)21(27-3)14-19(17)23(22)25/h6-9,12,14-15,22H,4-5,10-11,13H2,1-3H3
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n/an/a 0.140n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman method


Citation and Details

Article DOI: 10.1007/s00044-012-0227-3
BindingDB Entry DOI: 10.7270/Q24F1TN5
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50169863
PNG
(5,6-Dimethoxy-2-(4-piperidin-1-ylmethyl-phenoxy)-i...)
Show SMILES COc1cc2CC(Oc3ccc(CN4CCCCC4)cc3)C(=O)c2cc1OC
Show InChI InChI=1S/C23H27NO4/c1-26-20-12-17-13-22(23(25)19(17)14-21(20)27-2)28-18-8-6-16(7-9-18)15-24-10-4-3-5-11-24/h6-9,12,14,22H,3-5,10-11,13,15H2,1-2H3
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n/an/a 0.150n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman method


Citation and Details

Article DOI: 10.1007/s00044-012-0227-3
BindingDB Entry DOI: 10.7270/Q24F1TN5
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50169860
PNG
(2-[4-(1-Dimethylamino-ethyl)-phenoxy]-5,6-dimethox...)
Show SMILES COc1cc2CC(Oc3ccc(cc3)C(C)N(C)C)C(=O)c2cc1OC
Show InChI InChI=1S/C21H25NO4/c1-13(22(2)3)14-6-8-16(9-7-14)26-20-11-15-10-18(24-4)19(25-5)12-17(15)21(20)23/h6-10,12-13,20H,11H2,1-5H3
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n/an/a 0.150n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman method


Citation and Details

Article DOI: 10.1007/s00044-012-0227-3
BindingDB Entry DOI: 10.7270/Q24F1TN5
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50248849
PNG
(5,6-Dimethoxy-2-{4-[(pyrrolidin-1-yl)methyl]-benzy...)
Show SMILES COc1cc2CC(Cc3ccc(CN4CCCC4)cc3)C(=O)c2cc1OC
Show InChI InChI=1S/C23H27NO3/c1-26-21-13-18-12-19(23(25)20(18)14-22(21)27-2)11-16-5-7-17(8-6-16)15-24-9-3-4-10-24/h5-8,13-14,19H,3-4,9-12,15H2,1-2H3
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n/an/a 0.154n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman method


Citation and Details

Article DOI: 10.1007/s00044-012-0227-3
BindingDB Entry DOI: 10.7270/Q24F1TN5
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50248780
PNG
((E)-5,6-Dimethoxy-2-{3-[(piperidin-1-yl)methyl]-be...)
Show SMILES COc1cc2C\C(=C/c3cccc(CN4CCCCC4)c3)C(=O)c2cc1OC
Show InChI InChI=1S/C24H27NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-7-6-8-18(11-17)16-25-9-4-3-5-10-25/h6-8,11-12,14-15H,3-5,9-10,13,16H2,1-2H3/b20-12+
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n/an/a 0.162n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman method


Citation and Details

Article DOI: 10.1007/s00044-012-0227-3
BindingDB Entry DOI: 10.7270/Q24F1TN5
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM8963
PNG
(CHEMBL32823 | Homodimeric Tacrine Analog 3b | N-[7...)
Show SMILES C(CCCNc1c2CCCCc2nc2ccccc12)CCCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C33H40N4/c1(2-12-22-34-32-24-14-4-8-18-28(24)36-29-19-9-5-15-25(29)32)3-13-23-35-33-26-16-6-10-20-30(26)37-31-21-11-7-17-27(31)33/h4,6,8,10,14,16,18,20H,1-3,5,7,9,11-13,15,17,19,21-23H2,(H,34,36)(H,35,37)
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n/an/a 0.200n/an/an/an/a7.437



National Defense Medical Center



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Med Chem 45: 2277-82 (2002)


Article DOI: 10.1021/jm010308g
BindingDB Entry DOI: 10.7270/Q2KW5D89
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50235323
PNG
(CHEMBL4080023)
Show SMILES C(CCCCNc1c2CCCCc2nc2ccccc12)CCCNc1c2CCCCc2nc2CCCCc12
Show InChI InChI=1S/C34H46N4/c1(3-13-23-35-33-25-15-5-9-19-29(25)37-30-20-10-6-16-26(30)33)2-4-14-24-36-34-27-17-7-11-21-31(27)38-32-22-12-8-18-28(32)34/h5,9,15,19H,1-4,6-8,10-14,16-18,20-24H2,(H,35,37)(H,36,38)
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n/an/a 0.200n/an/an/an/an/an/a



Tehran University of Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of rat cortex AchE using acetylthiocholine iodide as substrate by Ellman's method


Eur J Med Chem 128: 332-345 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.060
BindingDB Entry DOI: 10.7270/Q2HM5BQX
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50169870
PNG
(2-(4-Dimethylaminomethyl-phenoxy)-5,6-dimethoxy-in...)
Show SMILES COc1cc2CC(Oc3ccc(CN(C)C)cc3)C(=O)c2cc1OC
Show InChI InChI=1S/C20H23NO4/c1-21(2)12-13-5-7-15(8-6-13)25-19-10-14-9-17(23-3)18(24-4)11-16(14)20(19)22/h5-9,11,19H,10,12H2,1-4H3
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n/an/a 0.210n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman method


Citation and Details

Article DOI: 10.1007/s00044-012-0227-3
BindingDB Entry DOI: 10.7270/Q24F1TN5
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50169859
PNG
(2-[4-(1-Diethylamino-ethyl)-phenoxy]-5,6-dimethoxy...)
Show SMILES CCN(CC)C(C)c1ccc(OC2Cc3cc(OC)c(OC)cc3C2=O)cc1
Show InChI InChI=1S/C23H29NO4/c1-6-24(7-2)15(3)16-8-10-18(11-9-16)28-22-13-17-12-20(26-4)21(27-5)14-19(17)23(22)25/h8-12,14-15,22H,6-7,13H2,1-5H3
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n/an/a 0.220n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman method


Citation and Details

Article DOI: 10.1007/s00044-012-0227-3
BindingDB Entry DOI: 10.7270/Q24F1TN5
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50248746
PNG
((E)-5,6-Dimethoxy-2-{3-[(pyrrolidin-1-yl)methyl]-b...)
Show SMILES COc1cc2C\C(=C/c3cccc(CN4CCCC4)c3)C(=O)c2cc1OC
Show InChI InChI=1S/C23H25NO3/c1-26-21-13-18-12-19(23(25)20(18)14-22(21)27-2)11-16-6-5-7-17(10-16)15-24-8-3-4-9-24/h5-7,10-11,13-14H,3-4,8-9,12,15H2,1-2H3/b19-11+
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n/an/a 0.237n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman method


Citation and Details

Article DOI: 10.1007/s00044-012-0227-3
BindingDB Entry DOI: 10.7270/Q24F1TN5
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50248712
PNG
((E)-2-{4-[(Ethylmethylamino)methyl]benzylidene}-5,...)
Show SMILES CCN(C)Cc1ccc(\C=C2/Cc3cc(OC)c(OC)cc3C2=O)cc1
Show InChI InChI=1S/C22H25NO3/c1-5-23(2)14-16-8-6-15(7-9-16)10-18-11-17-12-20(25-3)21(26-4)13-19(17)22(18)24/h6-10,12-13H,5,11,14H2,1-4H3/b18-10+
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n/an/a 0.266n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman method


Citation and Details

Article DOI: 10.1007/s00044-012-0227-3
BindingDB Entry DOI: 10.7270/Q24F1TN5
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50248819
PNG
(2-{4-[(Diethylamino)methyl]benzyl}-5,6-dimethoxy2,...)
Show SMILES CCN(CC)Cc1ccc(CC2Cc3cc(OC)c(OC)cc3C2=O)cc1
Show InChI InChI=1S/C23H29NO3/c1-5-24(6-2)15-17-9-7-16(8-10-17)11-19-12-18-13-21(26-3)22(27-4)14-20(18)23(19)25/h7-10,13-14,19H,5-6,11-12,15H2,1-4H3
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n/an/a 0.287n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman method


Citation and Details

Article DOI: 10.1007/s00044-012-0227-3
BindingDB Entry DOI: 10.7270/Q24F1TN5
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM9055
PNG
(6-chloro-N-{8-[(6-chloro-1,2,3,4-tetrahydroacridin...)
Show SMILES Clc1ccc2c(NCCCCCCCCNc3c4CCCCc4nc4cc(Cl)ccc34)c3CCCCc3nc2c1
Show InChI InChI=1S/C34H40Cl2N4/c35-23-15-17-27-31(21-23)39-29-13-7-5-11-25(29)33(27)37-19-9-3-1-2-4-10-20-38-34-26-12-6-8-14-30(26)40-32-22-24(36)16-18-28(32)34/h15-18,21-22H,1-14,19-20H2,(H,37,39)(H,38,40)
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n/an/a 0.300n/an/an/an/a7.437



National Defense Medical Center



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Med Chem 45: 2277-82 (2002)


Article DOI: 10.1021/jm010308g
BindingDB Entry DOI: 10.7270/Q2KW5D89
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50235324
PNG
(CHEMBL4104258)
Show SMILES Clc1ccc2c(NCCCCCCCCCNc3c4CCCCc4nc4CCCCc34)c3CCCCc3nc2c1
Show InChI InChI=1S/C35H47ClN4/c36-25-20-21-29-33(24-25)40-32-19-11-8-16-28(32)35(29)38-23-13-5-3-1-2-4-12-22-37-34-26-14-6-9-17-30(26)39-31-18-10-7-15-27(31)34/h20-21,24H,1-19,22-23H2,(H,37,39)(H,38,40)
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n/an/a 0.300n/an/an/an/an/an/a



Tehran University of Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of rat cortex AchE using acetylthiocholine iodide as substrate by Ellman's method


Eur J Med Chem 128: 332-345 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.060
BindingDB Entry DOI: 10.7270/Q2HM5BQX
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50037158
PNG
(CHEMBL106739 | Methyl-carbamic acid 3-({ethyl-[5-(...)
Show SMILES CCN(CCCCCN1C(=O)c2ccc(cc2C1=O)[N+]([O-])=O)Cc1cccc(OC(=O)NC)c1
Show InChI InChI=1S/C24H28N4O6/c1-3-26(16-17-8-7-9-19(14-17)34-24(31)25-2)12-5-4-6-13-27-22(29)20-11-10-18(28(32)33)15-21(20)23(27)30/h7-11,14-15H,3-6,12-13,16H2,1-2H3,(H,25,31)
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n/an/a 0.380n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd

Curated by ChEMBL


Assay Description
Inhibition concentration against rat acetylcholinesterase


J Med Chem 37: 3141-53 (1994)


Article DOI: 10.1021/jm00045a020
BindingDB Entry DOI: 10.7270/Q2JS9PHX
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50248816
PNG
(2-{4-[(Ethylmethylamino)methyl]benzyl}-5,6-dimetho...)
Show SMILES CCN(C)Cc1ccc(CC2Cc3cc(OC)c(OC)cc3C2=O)cc1
Show InChI InChI=1S/C22H27NO3/c1-5-23(2)14-16-8-6-15(7-9-16)10-18-11-17-12-20(25-3)21(26-4)13-19(17)22(18)24/h6-9,12-13,18H,5,10-11,14H2,1-4H3
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n/an/a 0.380n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman method


Citation and Details

Article DOI: 10.1007/s00044-012-0227-3
BindingDB Entry DOI: 10.7270/Q24F1TN5
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50149212
PNG
(CHEMBL117521 | N-(1,2,3,4,8a,10a-Hexahydro-acridin...)
Show SMILES C(CCCNC1=C2CCCCC2=NC2C=CCC=C12)CCCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C33H42N4/c1(2-12-22-34-32-24-14-4-8-18-28(24)36-29-19-9-5-15-25(29)32)3-13-23-35-33-26-16-6-10-20-30(26)37-31-21-11-7-17-27(31)33/h4,8,10,14,16,18,20,30,35H,1-3,5-7,9,11-13,15,17,19,21-23H2,(H,34,36)
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n/an/a 0.400n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibitory concentration against Acetylcholinesterase in rat brain


J Med Chem 47: 3463-82 (2004)


Article DOI: 10.1021/jm040031v
BindingDB Entry DOI: 10.7270/Q2NC61ZJ
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM8963
PNG
(CHEMBL32823 | Homodimeric Tacrine Analog 3b | N-[7...)
Show SMILES C(CCCNc1c2CCCCc2nc2ccccc12)CCCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C33H40N4/c1(2-12-22-34-32-24-14-4-8-18-28(24)36-29-19-9-5-15-25(29)32)3-13-23-35-33-26-16-6-10-20-30(26)37-31-21-11-7-17-27(31)33/h4,6,8,10,14,16,18,20H,1-3,5,7,9,11-13,15,17,19,21-23H2,(H,34,36)(H,35,37)
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n/an/a 0.400n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate measured after 8 mins in presence of BuChE inhibitor ethopropazine by Ellma...


Eur J Med Chem 132: 294-309 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.062
BindingDB Entry DOI: 10.7270/Q2HX1G33
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM8963
PNG
(CHEMBL32823 | Homodimeric Tacrine Analog 3b | N-[7...)
Show SMILES C(CCCNc1c2CCCCc2nc2ccccc12)CCCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C33H40N4/c1(2-12-22-34-32-24-14-4-8-18-28(24)36-29-19-9-5-15-25(29)32)3-13-23-35-33-26-16-6-10-20-30(26)37-31-21-11-7-17-27(31)33/h4,6,8,10,14,16,18,20H,1-3,5,7,9,11-13,15,17,19,21-23H2,(H,34,36)(H,35,37)
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n/an/a 0.400n/an/an/an/an/an/a



CSIR-Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat brain Acetylcholinesterase using acetylthiocholine as substrate in presence of BChE inhibitor ethopropazine by spectrophotometric m...


Bioorg Med Chem 27: 895-930 (2019)


Article DOI: 10.1016/j.bmc.2019.01.025
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50248637
PNG
((E)-2-{4-[(Dimethylamino)methyl]benzylidene}-5,6-d...)
Show SMILES COc1cc2C\C(=C/c3ccc(CN(C)C)cc3)C(=O)c2cc1OC
Show InChI InChI=1S/C21H23NO3/c1-22(2)13-15-7-5-14(6-8-15)9-17-10-16-11-19(24-3)20(25-4)12-18(16)21(17)23/h5-9,11-12H,10,13H2,1-4H3/b17-9+
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n/an/a 0.415n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman method


Citation and Details

Article DOI: 10.1007/s00044-012-0227-3
BindingDB Entry DOI: 10.7270/Q24F1TN5
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50248714
PNG
((E)-2-{3-[(Diethylamino)methyl]benzylidene}-5,6-di...)
Show SMILES CCN(CC)Cc1cccc(\C=C2/Cc3cc(OC)c(OC)cc3C2=O)c1
Show InChI InChI=1S/C23H27NO3/c1-5-24(6-2)15-17-9-7-8-16(10-17)11-19-12-18-13-21(26-3)22(27-4)14-20(18)23(19)25/h7-11,13-14H,5-6,12,15H2,1-4H3/b19-11+
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n/an/a 0.444n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman method


Citation and Details

Article DOI: 10.1007/s00044-012-0227-3
BindingDB Entry DOI: 10.7270/Q24F1TN5
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50248657
PNG
((E)-2-{3-[(Ethylmethylamino)methyl]benzylidene}-5,...)
Show SMILES CCN(C)Cc1cccc(\C=C2/Cc3cc(OC)c(OC)cc3C2=O)c1
Show InChI InChI=1S/C22H25NO3/c1-5-23(2)14-16-8-6-7-15(9-16)10-18-11-17-12-20(25-3)21(26-4)13-19(17)22(18)24/h6-10,12-13H,5,11,14H2,1-4H3/b18-10+
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n/an/a 0.487n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman method


Citation and Details

Article DOI: 10.1007/s00044-012-0227-3
BindingDB Entry DOI: 10.7270/Q24F1TN5
More data for this
Ligand-Target Pair
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