Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Integrase (Human immunodeficiency virus 1) | BDBM50559797![]() (CHEMBL4786078) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | PubMed | 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol Myers Squibb Curated by ChEMBL | Assay Description Binding affinity to wild type HIV1 integrase G140S/Q148H mutant | Bioorg Med Chem 28: (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50559796![]() (CHEMBL4779601) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | PubMed | 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol Myers Squibb Curated by ChEMBL | Assay Description Binding affinity to wild type HIV1 integrase G140S/Q148H mutant | Bioorg Med Chem 28: (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50527158![]() (CHEMBL4476366) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | Article PubMed | 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c... | J Med Chem 63: 2620-2637 (2020) Article DOI: 10.1021/acs.jmedchem.9b01681 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50527145![]() (CHEMBL4460705) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | Article PubMed | 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c... | J Med Chem 63: 2620-2637 (2020) Article DOI: 10.1021/acs.jmedchem.9b01681 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50527154![]() (CHEMBL4454255) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid PDB UniChem | PDB Article PubMed | 90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c... | J Med Chem 63: 2620-2637 (2020) Article DOI: 10.1021/acs.jmedchem.9b01681 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50527152![]() (CHEMBL4573064) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid PDB UniChem | PDB Article PubMed | 170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c... | J Med Chem 63: 2620-2637 (2020) Article DOI: 10.1021/acs.jmedchem.9b01681 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50527149![]() (CHEMBL4565963) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | Article PubMed | 310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c... | J Med Chem 63: 2620-2637 (2020) Article DOI: 10.1021/acs.jmedchem.9b01681 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50527146![]() (CHEMBL4538853) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | Article PubMed | 430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c... | J Med Chem 63: 2620-2637 (2020) Article DOI: 10.1021/acs.jmedchem.9b01681 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50527148![]() (CHEMBL4461955) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | Article PubMed | 680 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c... | J Med Chem 63: 2620-2637 (2020) Article DOI: 10.1021/acs.jmedchem.9b01681 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50495689![]() (CHEMBL3116306) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | Article PubMed | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lomonosov Moscow State University Curated by ChEMBL | Assay Description Non-competitive inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate after 1 hr by double-recipro... | Eur J Med Chem 73: 73-82 (2014) Article DOI: 10.1016/j.ejmech.2013.11.028 BindingDB Entry DOI: 10.7270/Q24M97H3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50527153![]() (CHEMBL4469948) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | Article PubMed | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c... | J Med Chem 63: 2620-2637 (2020) Article DOI: 10.1021/acs.jmedchem.9b01681 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50495689![]() (CHEMBL3116306) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | Article PubMed | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lomonosov Moscow State University Curated by ChEMBL | Assay Description Non-competitive inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate after 1 hr by double-recipro... | Eur J Med Chem 73: 73-82 (2014) Article DOI: 10.1016/j.ejmech.2013.11.028 BindingDB Entry DOI: 10.7270/Q24M97H3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50527152![]() (CHEMBL4573064) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid PDB UniChem | PDB Article PubMed | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c... | J Med Chem 63: 2620-2637 (2020) Article DOI: 10.1021/acs.jmedchem.9b01681 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50527150![]() (CHEMBL4541973) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | Article PubMed | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c... | J Med Chem 63: 2620-2637 (2020) Article DOI: 10.1021/acs.jmedchem.9b01681 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50527157![]() (CHEMBL4452801) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | Article PubMed | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c... | J Med Chem 63: 2620-2637 (2020) Article DOI: 10.1021/acs.jmedchem.9b01681 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50240448![]() (2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...) | PDB UniProtKB/TrEMBL GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lomonosov Moscow State University Curated by ChEMBL | Assay Description Non-competitive inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate after 1 hr by double-recipro... | Eur J Med Chem 73: 73-82 (2014) Article DOI: 10.1016/j.ejmech.2013.11.028 BindingDB Entry DOI: 10.7270/Q24M97H3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50527160![]() (CHEMBL4475105) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | Article PubMed | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c... | J Med Chem 63: 2620-2637 (2020) Article DOI: 10.1021/acs.jmedchem.9b01681 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50527144![]() (CHEMBL4587557) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | Article PubMed | 1.53E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c... | J Med Chem 63: 2620-2637 (2020) Article DOI: 10.1021/acs.jmedchem.9b01681 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50240448![]() (2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...) | PDB UniProtKB/TrEMBL GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 3.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lomonosov Moscow State University Curated by ChEMBL | Assay Description Competitive inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate after 1 hr by double-reciprocal ... | Eur J Med Chem 73: 73-82 (2014) Article DOI: 10.1016/j.ejmech.2013.11.028 BindingDB Entry DOI: 10.7270/Q24M97H3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50527151![]() (CHEMBL4440179) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | Article PubMed | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c... | J Med Chem 63: 2620-2637 (2020) Article DOI: 10.1021/acs.jmedchem.9b01681 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50527147![]() (CHEMBL4592796) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | Article PubMed | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c... | J Med Chem 63: 2620-2637 (2020) Article DOI: 10.1021/acs.jmedchem.9b01681 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50527156![]() (CHEMBL4551451) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | Article PubMed | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c... | J Med Chem 63: 2620-2637 (2020) Article DOI: 10.1021/acs.jmedchem.9b01681 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50527155![]() (CHEMBL4439901) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | Article PubMed | >5.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c... | J Med Chem 63: 2620-2637 (2020) Article DOI: 10.1021/acs.jmedchem.9b01681 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50527159![]() (CHEMBL4560817) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | Article PubMed | 6.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c... | J Med Chem 63: 2620-2637 (2020) Article DOI: 10.1021/acs.jmedchem.9b01681 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...) | BDBM168608![]() (US9079834, 2) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.0190 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Canada Inc. US Patent | Assay Description Assays for the inhibition of acute HIV infection of T-lymphoid cells were conducted in accordance with Vacca, J.P. et al, Proc. Natl. Acad. Sci. USA ... | US Patent US9079834 (2015) BindingDB Entry DOI: 10.7270/Q2PV6J44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...) | BDBM60467![]() (BDBM168607 | US9079834, 1-1) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Canada Inc. US Patent | Assay Description Assays for the inhibition of acute HIV infection of T-lymphoid cells were conducted in accordance with Vacca, J.P. et al, Proc. Natl. Acad. Sci. USA ... | US Patent US9079834 (2015) BindingDB Entry DOI: 10.7270/Q2PV6J44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...) | BDBM60623![]() (BDBM180165 | US9133157, 103) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a | 5.5 | 25 |
Merck Canada Inc. US Patent | Assay Description The inhibition of WT HIV-1 protease was studied using the reaction of the protease (expressed in Eschericia coli) with a peptide substrate [Val-Ser-G... | US Patent US9133157 (2015) BindingDB Entry DOI: 10.7270/Q2Q52NDV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...) | BDBM180212![]() (US9133157, 94) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a | 5.5 | 25 |
Merck Canada Inc. US Patent | Assay Description The inhibition of WT HIV-1 protease was studied using the reaction of the protease (expressed in Eschericia coli) with a peptide substrate [Val-Ser-G... | US Patent US9133157 (2015) BindingDB Entry DOI: 10.7270/Q2Q52NDV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...) | BDBM180171![]() (US9133157, 53) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.156 | n/a | n/a | n/a | n/a | 5.5 | 25 |
Merck Canada Inc. US Patent | Assay Description The inhibition of WT HIV-1 protease was studied using the reaction of the protease (expressed in Eschericia coli) with a peptide substrate [Val-Ser-G... | US Patent US9133157 (2015) BindingDB Entry DOI: 10.7270/Q2Q52NDV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...) | BDBM180183![]() (US9133157, 65) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.180 | n/a | n/a | n/a | n/a | 5.5 | 25 |
Merck Canada Inc. US Patent | Assay Description The inhibition of WT HIV-1 protease was studied using the reaction of the protease (expressed in Eschericia coli) with a peptide substrate [Val-Ser-G... | US Patent US9133157 (2015) BindingDB Entry DOI: 10.7270/Q2Q52NDV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...) | BDBM180163![]() (US9133157, 44) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.196 | n/a | n/a | n/a | n/a | 5.5 | 25 |
Merck Canada Inc. US Patent | Assay Description The inhibition of WT HIV-1 protease was studied using the reaction of the protease (expressed in Eschericia coli) with a peptide substrate [Val-Ser-G... | US Patent US9133157 (2015) BindingDB Entry DOI: 10.7270/Q2Q52NDV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...) | BDBM180201![]() (US9133157, 83) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | 5.5 | 25 |
Merck Canada Inc. US Patent | Assay Description The inhibition of WT HIV-1 protease was studied using the reaction of the protease (expressed in Eschericia coli) with a peptide substrate [Val-Ser-G... | US Patent US9133157 (2015) BindingDB Entry DOI: 10.7270/Q2Q52NDV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...) | BDBM180164![]() (US9133157, 102 | US9133157, 45) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.308 | n/a | n/a | n/a | n/a | 5.5 | 25 |
Merck Canada Inc. US Patent | Assay Description The inhibition of WT HIV-1 protease was studied using the reaction of the protease (expressed in Eschericia coli) with a peptide substrate [Val-Ser-G... | US Patent US9133157 (2015) BindingDB Entry DOI: 10.7270/Q2Q52NDV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...) | BDBM180211![]() (US9133157, 93) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.310 | n/a | n/a | n/a | n/a | 5.5 | 25 |
Merck Canada Inc. US Patent | Assay Description The inhibition of WT HIV-1 protease was studied using the reaction of the protease (expressed in Eschericia coli) with a peptide substrate [Val-Ser-G... | US Patent US9133157 (2015) BindingDB Entry DOI: 10.7270/Q2Q52NDV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...) | BDBM180119![]() (US9133157, 8) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.310 | n/a | n/a | n/a | n/a | 5.5 | 25 |
Merck Canada Inc. US Patent | Assay Description The inhibition of WT HIV-1 protease was studied using the reaction of the protease (expressed in Eschericia coli) with a peptide substrate [Val-Ser-G... | US Patent US9133157 (2015) BindingDB Entry DOI: 10.7270/Q2Q52NDV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...) | BDBM180206![]() (US9133157, 88) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.330 | n/a | n/a | n/a | n/a | 5.5 | 25 |
Merck Canada Inc. US Patent | Assay Description The inhibition of WT HIV-1 protease was studied using the reaction of the protease (expressed in Eschericia coli) with a peptide substrate [Val-Ser-G... | US Patent US9133157 (2015) BindingDB Entry DOI: 10.7270/Q2Q52NDV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...) | BDBM180203![]() (US9133157, 85) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.330 | n/a | n/a | n/a | n/a | 5.5 | 25 |
Merck Canada Inc. US Patent | Assay Description The inhibition of WT HIV-1 protease was studied using the reaction of the protease (expressed in Eschericia coli) with a peptide substrate [Val-Ser-G... | US Patent US9133157 (2015) BindingDB Entry DOI: 10.7270/Q2Q52NDV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...) | BDBM180204![]() (US9133157, 86) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.340 | n/a | n/a | n/a | n/a | 5.5 | 25 |
Merck Canada Inc. US Patent | Assay Description The inhibition of WT HIV-1 protease was studied using the reaction of the protease (expressed in Eschericia coli) with a peptide substrate [Val-Ser-G... | US Patent US9133157 (2015) BindingDB Entry DOI: 10.7270/Q2Q52NDV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...) | BDBM168610![]() (US9079834, 5) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.390 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Canada Inc. US Patent | Assay Description Assays for the inhibition of acute HIV infection of T-lymphoid cells were conducted in accordance with Vacca, J.P. et al, Proc. Natl. Acad. Sci. USA ... | US Patent US9079834 (2015) BindingDB Entry DOI: 10.7270/Q2PV6J44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...) | BDBM50461442![]() (CHEMBL4225363) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Binding affinity to CA-SP1 P373S/V370A double mutant in HIV-1 subtype B NL4-3 infected in human MT2 cells assessed as inhibition of viral maturation ... | Bioorg Med Chem Lett 28: 1550-1557 (2018) Article DOI: 10.1016/j.bmcl.2018.03.067 BindingDB Entry DOI: 10.7270/Q29G5QFN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...) | BDBM50461431![]() (CHEMBL4228517) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.420 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Binding affinity to CA-SP1 P373S/V370A double mutant in HIV-1 subtype B NL4-3 infected in human MT2 cells assessed as inhibition of viral maturation ... | Bioorg Med Chem Lett 28: 1550-1557 (2018) Article DOI: 10.1016/j.bmcl.2018.03.067 BindingDB Entry DOI: 10.7270/Q29G5QFN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...) | BDBM168612![]() (US9079834, 7) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.430 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Canada Inc. US Patent | Assay Description Assays for the inhibition of acute HIV infection of T-lymphoid cells were conducted in accordance with Vacca, J.P. et al, Proc. Natl. Acad. Sci. USA ... | US Patent US9079834 (2015) BindingDB Entry DOI: 10.7270/Q2PV6J44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...) | BDBM180135![]() (US9133157, 16) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.440 | n/a | n/a | n/a | n/a | 5.5 | 25 |
Merck Canada Inc. US Patent | Assay Description The inhibition of WT HIV-1 protease was studied using the reaction of the protease (expressed in Eschericia coli) with a peptide substrate [Val-Ser-G... | US Patent US9133157 (2015) BindingDB Entry DOI: 10.7270/Q2Q52NDV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...) | BDBM180216![]() (US9133157, 98) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.440 | n/a | n/a | n/a | n/a | 5.5 | 25 |
Merck Canada Inc. US Patent | Assay Description The inhibition of WT HIV-1 protease was studied using the reaction of the protease (expressed in Eschericia coli) with a peptide substrate [Val-Ser-G... | US Patent US9133157 (2015) BindingDB Entry DOI: 10.7270/Q2Q52NDV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...) | BDBM180192![]() (US9133157, 74) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.450 | n/a | n/a | n/a | n/a | 5.5 | 25 |
Merck Canada Inc. US Patent | Assay Description The inhibition of WT HIV-1 protease was studied using the reaction of the protease (expressed in Eschericia coli) with a peptide substrate [Val-Ser-G... | US Patent US9133157 (2015) BindingDB Entry DOI: 10.7270/Q2Q52NDV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...) | BDBM180232![]() (US9133157, 117) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.470 | n/a | n/a | n/a | n/a | 5.5 | 25 |
Merck Canada Inc. US Patent | Assay Description The inhibition of WT HIV-1 protease was studied using the reaction of the protease (expressed in Eschericia coli) with a peptide substrate [Val-Ser-G... | US Patent US9133157 (2015) BindingDB Entry DOI: 10.7270/Q2Q52NDV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50021581![]() (CHEMBL414850 | L-870810) | PDB UniProtKB/TrEMBL GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lille 1 Curated by ChEMBL | Assay Description Inhibition of HIV1 integrase | J Med Chem 51: 7717-30 (2008) Article DOI: 10.1021/jm8007085 BindingDB Entry DOI: 10.7270/Q2222XJ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50021581![]() (CHEMBL414850 | L-870810) | PDB UniProtKB/TrEMBL GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lille 1 Curated by ChEMBL | Assay Description Inhibition of HIV1 integrase using labelled oligonucleotide substrate by ELISA | J Med Chem 51: 2575-9 (2008) Article DOI: 10.1021/jm7011134 BindingDB Entry DOI: 10.7270/Q26M39K5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM23402![]() (5-(1,1-dioxo-1,2-thiazinan-2-yl)-N-[(4-fluoropheny...) | PDB MMDB UniProtKB/TrEMBL DrugBank GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Messina Curated by ChEMBL | Assay Description In vitro concentration required to inhibit the overall HIV-1 integrase strand transfer | J Med Chem 48: 7084-8 (2005) Article DOI: 10.1021/jm050549e BindingDB Entry DOI: 10.7270/Q27W6BR1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50062551![]() (CHEBI:76010 | DOLUTEGRAVIR | Dolutegravir | GSK134...) | PDB UniProtKB/TrEMBL GoogleScholar | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University Curated by ChEMBL | Assay Description Inhibition of HIV integrase strand transfer activity | Bioorg Med Chem 27: 3836-3845 (2019) Article DOI: 10.1016/j.bmc.2019.07.011 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |
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