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Compile Data Set for Download or QSAR

Found 968 hits Enz. Inhib. hit(s) with Target = 'Leucine aminopeptidase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
leucine aminopeptidase


(Plasmodium falciparum 3D7)
BDBM50497553
PNG
(CHEMBL3359696)
Show SMILES ONC(=O)C(NC(=O)c1ccccc1F)c1ccc(cc1)-n1cccn1
Show InChI InChI=1S/C18H15FN4O3/c19-15-5-2-1-4-14(15)17(24)21-16(18(25)22-26)12-6-8-13(9-7-12)23-11-3-10-20-23/h1-11,16,26H,(H,21,24)(H,22,25)
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0.00800n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum M17 incubated for 10 mins before H-Leu-NHMec substrate addition by fluorescence assay


J Med Chem 57: 9168-83 (2014)


Article DOI: 10.1021/jm501323a
BindingDB Entry DOI: 10.7270/Q2QN69RJ
More data for this
Ligand-Target Pair
leucine aminopeptidase


(Plasmodium falciparum 3D7)
BDBM50497551
PNG
(CHEMBL3359700)
Show SMILES Nc1ccc(cc1)C(=O)NC(C(=O)NO)c1ccc(cc1)-n1cccn1
Show InChI InChI=1S/C18H17N5O3/c19-14-6-2-13(3-7-14)17(24)21-16(18(25)22-26)12-4-8-15(9-5-12)23-11-1-10-20-23/h1-11,16,26H,19H2,(H,21,24)(H,22,25)
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0.0110n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum M17 incubated for 10 mins before H-Leu-NHMec substrate addition by fluorescence assay


J Med Chem 57: 9168-83 (2014)


Article DOI: 10.1021/jm501323a
BindingDB Entry DOI: 10.7270/Q2QN69RJ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
leucine aminopeptidase


(Plasmodium falciparum 3D7)
BDBM50497552
PNG
(CHEMBL3359698)
Show SMILES ONC(=O)C(NC(=O)c1ccc(F)cc1)c1ccc(cc1)-n1cccn1
Show InChI InChI=1S/C18H15FN4O3/c19-14-6-2-13(3-7-14)17(24)21-16(18(25)22-26)12-4-8-15(9-5-12)23-11-1-10-20-23/h1-11,16,26H,(H,21,24)(H,22,25)
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0.0120n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum M17 incubated for 10 mins before H-Leu-NHMec substrate addition by fluorescence assay


J Med Chem 57: 9168-83 (2014)


Article DOI: 10.1021/jm501323a
BindingDB Entry DOI: 10.7270/Q2QN69RJ
More data for this
Ligand-Target Pair
leucine aminopeptidase


(Plasmodium falciparum 3D7)
BDBM50497556
PNG
(CHEMBL3359699)
Show SMILES Nc1cccc(c1)C(=O)NC(C(=O)NO)c1ccc(cc1)-n1cccn1
Show InChI InChI=1S/C18H17N5O3/c19-14-4-1-3-13(11-14)17(24)21-16(18(25)22-26)12-5-7-15(8-6-12)23-10-2-9-20-23/h1-11,16,26H,19H2,(H,21,24)(H,22,25)
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0.0140n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum M17 incubated for 10 mins before H-Leu-NHMec substrate addition by fluorescence assay


J Med Chem 57: 9168-83 (2014)


Article DOI: 10.1021/jm501323a
BindingDB Entry DOI: 10.7270/Q2QN69RJ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
leucine aminopeptidase


(Plasmodium falciparum 3D7)
BDBM50497548
PNG
(CHEMBL3359691)
Show SMILES CCC(=O)NC(C(=O)NO)c1ccc(cc1)-n1cccn1
Show InChI InChI=1S/C14H16N4O3/c1-2-12(19)16-13(14(20)17-21)10-4-6-11(7-5-10)18-9-3-8-15-18/h3-9,13,21H,2H2,1H3,(H,16,19)(H,17,20)
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0.0160n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum M17 incubated for 10 mins before H-Leu-NHMec substrate addition by fluorescence assay


J Med Chem 57: 9168-83 (2014)


Article DOI: 10.1021/jm501323a
BindingDB Entry DOI: 10.7270/Q2QN69RJ
More data for this
Ligand-Target Pair
leucine aminopeptidase


(Plasmodium falciparum 3D7)
BDBM50497549
PNG
(CHEMBL3359690)
Show SMILES CC(=O)NC(C(=O)NO)c1ccc(cc1)-n1cccn1
Show InChI InChI=1S/C13H14N4O3/c1-9(18)15-12(13(19)16-20)10-3-5-11(6-4-10)17-8-2-7-14-17/h2-8,12,20H,1H3,(H,15,18)(H,16,19)
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0.0190n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum M17 incubated for 10 mins before H-Leu-NHMec substrate addition by fluorescence assay


J Med Chem 57: 9168-83 (2014)


Article DOI: 10.1021/jm501323a
BindingDB Entry DOI: 10.7270/Q2QN69RJ
More data for this
Ligand-Target Pair
leucine aminopeptidase


(Plasmodium falciparum 3D7)
BDBM50497543
PNG
(CHEMBL3359693)
Show SMILES CC(C)(C)C(=O)NC(C(=O)NO)c1ccc(cc1)-n1cccn1
Show InChI InChI=1S/C16H20N4O3/c1-16(2,3)15(22)18-13(14(21)19-23)11-5-7-12(8-6-11)20-10-4-9-17-20/h4-10,13,23H,1-3H3,(H,18,22)(H,19,21)
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0.0280n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum M17 incubated for 10 mins before H-Leu-NHMec substrate addition by fluorescence assay


J Med Chem 57: 9168-83 (2014)


Article DOI: 10.1021/jm501323a
BindingDB Entry DOI: 10.7270/Q2QN69RJ
More data for this
Ligand-Target Pair
leucine aminopeptidase


(Plasmodium falciparum 3D7)
BDBM50497544
PNG
(CHEMBL3359688)
Show SMILES CC(C)(C)OC(=O)NC(C(=O)NO)c1ccc(cc1)-n1cccn1
Show InChI InChI=1S/C16H20N4O4/c1-16(2,3)24-15(22)18-13(14(21)19-23)11-5-7-12(8-6-11)20-10-4-9-17-20/h4-10,13,23H,1-3H3,(H,18,22)(H,19,21)
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0.0300n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum M17 incubated for 10 mins before H-Leu-NHMec substrate addition by fluorescence assay


J Med Chem 57: 9168-83 (2014)


Article DOI: 10.1021/jm501323a
BindingDB Entry DOI: 10.7270/Q2QN69RJ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
leucine aminopeptidase


(Plasmodium falciparum 3D7)
BDBM50497545
PNG
(CHEMBL3359697)
Show SMILES ONC(=O)C(NC(=O)c1cccc(F)c1)c1ccc(cc1)-n1cccn1
Show InChI InChI=1S/C18H15FN4O3/c19-14-4-1-3-13(11-14)17(24)21-16(18(25)22-26)12-5-7-15(8-6-12)23-10-2-9-20-23/h1-11,16,26H,(H,21,24)(H,22,25)
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0.0350n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum M17 incubated for 10 mins before H-Leu-NHMec substrate addition by fluorescence assay


J Med Chem 57: 9168-83 (2014)


Article DOI: 10.1021/jm501323a
BindingDB Entry DOI: 10.7270/Q2QN69RJ
More data for this
Ligand-Target Pair
leucine aminopeptidase


(Plasmodium falciparum 3D7)
BDBM50497547
PNG
(CHEMBL3359694)
Show SMILES CC(C)(C)NC(=O)NC(C(=O)NO)c1ccc(cc1)-n1cccn1
Show InChI InChI=1S/C16H21N5O3/c1-16(2,3)19-15(23)18-13(14(22)20-24)11-5-7-12(8-6-11)21-10-4-9-17-21/h4-10,13,24H,1-3H3,(H,20,22)(H2,18,19,23)
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0.0380n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum M17 incubated for 10 mins before H-Leu-NHMec substrate addition by fluorescence assay


J Med Chem 57: 9168-83 (2014)


Article DOI: 10.1021/jm501323a
BindingDB Entry DOI: 10.7270/Q2QN69RJ
More data for this
Ligand-Target Pair
leucine aminopeptidase


(Plasmodium falciparum 3D7)
BDBM50497557
PNG
(CHEMBL3359692)
Show SMILES CC(C)C(=O)NC(C(=O)NO)c1ccc(cc1)-n1cccn1
Show InChI InChI=1S/C15H18N4O3/c1-10(2)14(20)17-13(15(21)18-22)11-4-6-12(7-5-11)19-9-3-8-16-19/h3-10,13,22H,1-2H3,(H,17,20)(H,18,21)
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0.0530n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum M17 incubated for 10 mins before H-Leu-NHMec substrate addition by fluorescence assay


J Med Chem 57: 9168-83 (2014)


Article DOI: 10.1021/jm501323a
BindingDB Entry DOI: 10.7270/Q2QN69RJ
More data for this
Ligand-Target Pair
leucine aminopeptidase


(Plasmodium falciparum 3D7)
BDBM50497546
PNG
(CHEMBL3359695)
Show SMILES ONC(=O)C(NC(=O)c1ccccc1)c1ccc(cc1)-n1cccn1
Show InChI InChI=1S/C18H16N4O3/c23-17(14-5-2-1-3-6-14)20-16(18(24)21-25)13-7-9-15(10-8-13)22-12-4-11-19-22/h1-12,16,25H,(H,20,23)(H,21,24)
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0.154n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum M17 incubated for 10 mins before H-Leu-NHMec substrate addition by fluorescence assay


J Med Chem 57: 9168-83 (2014)


Article DOI: 10.1021/jm501323a
BindingDB Entry DOI: 10.7270/Q2QN69RJ
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50024594
PNG
((R)-1-Ammonium-3-methyl-butane-1-phosphonic acid a...)
Show SMILES CC(C)C[C@H]([NH3+])P(O)([O-])=O
Show InChI InChI=1S/C5H14NO3P/c1-4(2)3-5(6)10(7,8)9/h4-5H,3,6H2,1-2H3,(H2,7,8,9)/t5-/m1/s1
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0.230n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
BindingDB Entry DOI: 10.7270/Q2CF9RQF
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50316049
PNG
(1-amino-3-phenylpropylphosphonic acid | CHEMBL1090...)
Show SMILES NC(CCc1ccccc1)P(O)(O)=O
Show InChI InChI=1S/C9H14NO3P/c10-9(14(11,12)13)7-6-8-4-2-1-3-5-8/h1-5,9H,6-7,10H2,(H2,11,12,13)
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4.60n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
BindingDB Entry DOI: 10.7270/Q2CF9RQF
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50025048
PNG
(CHEMBL3355099)
Show SMILES N[C@@H](CCc1ccccc1)P(O)(O)=O
Show InChI InChI=1S/C9H14NO3P/c10-9(14(11,12)13)7-6-8-4-2-1-3-5-8/h1-5,9H,6-7,10H2,(H2,11,12,13)/t9-/m1/s1
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5n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
BindingDB Entry DOI: 10.7270/Q2CF9RQF
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50078125
PNG
((1-Amino-3-phenyl-propyl)-phosphinic acid | CHEMBL...)
Show SMILES OP(O)C(=N)CCc1ccccc1
Show InChI InChI=1S/C9H12NO2P/c10-9(13(11)12)7-6-8-4-2-1-3-5-8/h1-5,10-12H,6-7H2
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7.70n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
BindingDB Entry DOI: 10.7270/Q2CF9RQF
More data for this
Ligand-Target Pair
leucine aminopeptidase


(Plasmodium falciparum 3D7)
BDBM50190112
PNG
(CHEMBL88808)
Show SMILES NC(CCc1ccccc1)P(O)(=O)CC(Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C19H24NO5P/c20-18(11-8-14-4-2-1-3-5-14)26(24,25)13-16(19(22)23)12-15-6-9-17(21)10-7-15/h1-7,9-10,16,18,21H,8,11-13,20H2,(H,22,23)(H,24,25)
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10n/an/an/an/an/an/an/an/a



Wroc?aw University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum LAP


Bioorg Med Chem Lett 29: 1031-1042 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.034
More data for this
Ligand-Target Pair
leucine aminopeptidase


(Plasmodium falciparum 3D7)
BDBM50190111
PNG
(CHEMBL327844)
Show SMILES NC(CCc1ccccc1)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C19H24NO4P/c20-18(12-11-15-7-3-1-4-8-15)25(23,24)14-17(19(21)22)13-16-9-5-2-6-10-16/h1-10,17-18H,11-14,20H2,(H,21,22)(H,23,24)
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13n/an/an/an/an/an/an/an/a



Wroc?aw University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum LAP


Bioorg Med Chem Lett 29: 1031-1042 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.034
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50025043
PNG
(CHEMBL3355104)
Show SMILES NC(CCc1ccc(CO)cc1)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C20H26NO5P/c21-19(11-10-15-6-8-17(13-22)9-7-15)27(25,26)14-18(20(23)24)12-16-4-2-1-3-5-16/h1-9,18-19,22H,10-14,21H2,(H,23,24)(H,25,26)
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20n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
BindingDB Entry DOI: 10.7270/Q2CF9RQF
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Sus scrofa)
BDBM50022748
PNG
(2-Amino-4-methyl-pentane-1-thiol | CHEMBL69349)
Show SMILES CC(C)C[C@@H](N)CS
Show InChI InChI=1S/C6H15NS/c1-5(2)3-6(7)4-8/h5-6,8H,3-4,7H2,1-2H3/t6-/m1/s1
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22n/an/an/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Competitive inhibition of LAP in porcine kidney microsomes


J Med Chem 61: 6468-6490 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00782
BindingDB Entry DOI: 10.7270/Q28S4SHS
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50025041
PNG
(CHEMBL3355106)
Show SMILES NC(CCc1ccncc1)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C18H23N2O4P/c19-17(7-6-14-8-10-20-11-9-14)25(23,24)13-16(18(21)22)12-15-4-2-1-3-5-15/h1-5,8-11,16-17H,6-7,12-13,19H2,(H,21,22)(H,23,24)
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39n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
BindingDB Entry DOI: 10.7270/Q2CF9RQF
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50025042
PNG
(CHEMBL3355105)
Show SMILES NC(CCc1cccnc1)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C18H23N2O4P/c19-17(9-8-15-7-4-10-20-12-15)25(23,24)13-16(18(21)22)11-14-5-2-1-3-6-14/h1-7,10,12,16-17H,8-9,11,13,19H2,(H,21,22)(H,23,24)
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50n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
BindingDB Entry DOI: 10.7270/Q2CF9RQF
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Sus scrofa)
BDBM50190111
PNG
(CHEMBL327844)
Show SMILES NC(CCc1ccccc1)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C19H24NO4P/c20-18(12-11-15-7-3-1-4-8-15)25(23,24)14-17(19(21)22)13-16-9-5-2-6-10-16/h1-10,17-18H,11-14,20H2,(H,21,22)(H,23,24)
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66n/an/an/an/an/an/an/an/a



Wroc?aw University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine LAP


Bioorg Med Chem Lett 29: 1031-1042 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.034
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50129684
PNG
(3-[(1-amino-3-phenyl-propyl)-hydroxy-phosphinoyl]-...)
Show SMILES OC(=O)C(Cc1ccccc1)CP(O)(O)C(=N)CCc1ccccc1
Show InChI InChI=1S/C19H24NO4P/c20-18(12-11-15-7-3-1-4-8-15)25(23,24)14-17(19(21)22)13-16-9-5-2-6-10-16/h1-10,17,20,23-25H,11-14H2,(H,21,22)
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66n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
BindingDB Entry DOI: 10.7270/Q2CF9RQF
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Sus scrofa)
BDBM50190112
PNG
(CHEMBL88808)
Show SMILES NC(CCc1ccccc1)P(O)(=O)CC(Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C19H24NO5P/c20-18(11-8-14-4-2-1-3-5-14)26(24,25)13-16(19(22)23)12-15-6-9-17(21)10-7-15/h1-7,9-10,16,18,21H,8,11-13,20H2,(H,22,23)(H,24,25)
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67n/an/an/an/an/an/an/an/a



Wroc?aw University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine LAP


Bioorg Med Chem Lett 29: 1031-1042 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.034
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50129681
PNG
(3-[(1-Amino-3-phenyl-propyl)-hydroxy-phosphinoyl]-...)
Show SMILES OC(=O)C(Cc1ccc(O)cc1)CP(O)(O)C(=N)CCc1ccccc1
Show InChI InChI=1S/C19H24NO5P/c20-18(11-8-14-4-2-1-3-5-14)26(24,25)13-16(19(22)23)12-15-6-9-17(21)10-7-15/h1-7,9-10,16,20-21,24-26H,8,11-13H2,(H,22,23)
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67n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
BindingDB Entry DOI: 10.7270/Q2CF9RQF
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50025070
PNG
(CHEMBL3355110)
Show SMILES NCc1ccc(CC(CP(O)(=O)C(N)CCc2cccnc2)C(O)=O)cc1
Show InChI InChI=1S/C19H26N3O4P/c20-11-15-5-3-14(4-6-15)10-17(19(23)24)13-27(25,26)18(21)8-7-16-2-1-9-22-12-16/h1-6,9,12,17-18H,7-8,10-11,13,20-21H2,(H,23,24)(H,25,26)
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74n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
BindingDB Entry DOI: 10.7270/Q2CF9RQF
More data for this
Ligand-Target Pair
leucine aminopeptidase


(Plasmodium falciparum 3D7)
BDBM50497554
PNG
(CHEMBL3359689)
Show SMILES Cl.NC(C(=O)NO)c1ccc(cc1)-n1cccn1
Show InChI InChI=1S/C11H12N4O2.ClH/c12-10(11(16)14-17)8-2-4-9(5-3-8)15-7-1-6-13-15;/h1-7,10,17H,12H2,(H,14,16);1H
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86n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum M17 incubated for 10 mins before H-Leu-NHMec substrate addition by fluorescence assay


J Med Chem 57: 9168-83 (2014)


Article DOI: 10.1021/jm501323a
BindingDB Entry DOI: 10.7270/Q2QN69RJ
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50025099
PNG
(CHEMBL3355111)
Show SMILES NCc1cccc(CC(CP(O)(=O)C(N)CCc2ccncc2)C(O)=O)c1
Show InChI InChI=1S/C19H26N3O4P/c20-12-16-3-1-2-15(10-16)11-17(19(23)24)13-27(25,26)18(21)5-4-14-6-8-22-9-7-14/h1-3,6-10,17-18H,4-5,11-13,20-21H2,(H,23,24)(H,25,26)
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108n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
BindingDB Entry DOI: 10.7270/Q2CF9RQF
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50025066
PNG
(CHEMBL3355109)
Show SMILES NCc1ccc(CC(CP(O)(=O)C(N)CCc2ccccc2)C(O)=O)cc1
Show InChI InChI=1S/C20H27N2O4P/c21-13-17-8-6-16(7-9-17)12-18(20(23)24)14-27(25,26)19(22)11-10-15-4-2-1-3-5-15/h1-9,18-19H,10-14,21-22H2,(H,23,24)(H,25,26)
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138n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
BindingDB Entry DOI: 10.7270/Q2CF9RQF
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50025044
PNG
(CHEMBL3355103)
Show SMILES NC(CCc1ccc(O)cc1)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C19H24NO5P/c20-18(11-8-14-6-9-17(21)10-7-14)26(24,25)13-16(19(22)23)12-15-4-2-1-3-5-15/h1-7,9-10,16,18,21H,8,11-13,20H2,(H,22,23)(H,24,25)
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157n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
BindingDB Entry DOI: 10.7270/Q2CF9RQF
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50025050
PNG
(CHEMBL3355108)
Show SMILES NCc1cccc(CC(CP(O)(=O)C(N)CCc2ccccc2)C(O)=O)c1
Show InChI InChI=1S/C20H27N2O4P/c21-13-17-8-4-7-16(11-17)12-18(20(23)24)14-27(25,26)19(22)10-9-15-5-2-1-3-6-15/h1-8,11,18-19H,9-10,12-14,21-22H2,(H,23,24)(H,25,26)
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195n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
BindingDB Entry DOI: 10.7270/Q2CF9RQF
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50337147
PNG
((RS)-1-amino-3-cyclohexylpropylphosphonic acid | C...)
Show SMILES NC(CCC1CCCCC1)P(O)(O)=O
Show InChI InChI=1S/C9H20NO3P/c10-9(14(11,12)13)7-6-8-4-2-1-3-5-8/h8-9H,1-7,10H2,(H2,11,12,13)
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210n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50025047
PNG
(CHEMBL3355100)
Show SMILES Cc1cc(C)cc(CCC(N)P(O)(=O)CC(Cc2ccccc2)C(O)=O)c1
Show InChI InChI=1S/C21H28NO4P/c1-15-10-16(2)12-18(11-15)8-9-20(22)27(25,26)14-19(21(23)24)13-17-6-4-3-5-7-17/h3-7,10-12,19-20H,8-9,13-14,22H2,1-2H3,(H,23,24)(H,25,26)
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213n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
BindingDB Entry DOI: 10.7270/Q2CF9RQF
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50025046
PNG
(CHEMBL3355101)
Show SMILES NC(CCc1ccc(cc1)[N+]([O-])=O)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C19H23N2O6P/c20-18(11-8-14-6-9-17(10-7-14)21(24)25)28(26,27)13-16(19(22)23)12-15-4-2-1-3-5-15/h1-7,9-10,16,18H,8,11-13,20H2,(H,22,23)(H,26,27)
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215n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
BindingDB Entry DOI: 10.7270/Q2CF9RQF
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50024597
PNG
((S)-1-Ammonium-3-methyl-butane-1-phosphonic acid a...)
Show SMILES CC(C)C[C@@H]([NH3+])P(O)([O-])=O
Show InChI InChI=1S/C5H14NO3P/c1-4(2)3-5(6)10(7,8)9/h4-5H,3,6H2,1-2H3,(H2,7,8,9)/t5-/m0/s1
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220n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
BindingDB Entry DOI: 10.7270/Q2CF9RQF
More data for this
Ligand-Target Pair
leucine aminopeptidase


(Plasmodium falciparum 3D7)
BDBM50497555
PNG
(CHEMBL3359686)
Show SMILES CC(C)(C)OC(=O)NC(C(O)=O)c1ccc(cc1)-n1cccn1
Show InChI InChI=1S/C16H19N3O4/c1-16(2,3)23-15(22)18-13(14(20)21)11-5-7-12(8-6-11)19-10-4-9-17-19/h4-10,13H,1-3H3,(H,18,22)(H,20,21)
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464n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum M17 incubated for 10 mins before H-Leu-NHMec substrate addition by fluorescence assay


J Med Chem 57: 9168-83 (2014)


Article DOI: 10.1021/jm501323a
BindingDB Entry DOI: 10.7270/Q2QN69RJ
More data for this
Ligand-Target Pair
leucine aminopeptidase


(Plasmodium falciparum 3D7)
BDBM50497550
PNG
(CHEMBL3359687)
Show SMILES Cl.NC(C(O)=O)c1ccc(cc1)-n1cccn1
Show InChI InChI=1S/C11H11N3O2.ClH/c12-10(11(15)16)8-2-4-9(5-3-8)14-7-1-6-13-14;/h1-7,10H,12H2,(H,15,16);1H
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>500n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum M17 incubated for 10 mins before H-Leu-NHMec substrate addition by fluorescence assay


J Med Chem 57: 9168-83 (2014)


Article DOI: 10.1021/jm501323a
BindingDB Entry DOI: 10.7270/Q2QN69RJ
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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500n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of bovine LAPc using L-leucine-p-nitroanilide as substrate by spectrophotometric analysis


Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50025045
PNG
(CHEMBL3355102)
Show SMILES NC(CCc1cccc(O)c1)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C19H24NO5P/c20-18(10-9-15-7-4-8-17(21)12-15)26(24,25)13-16(19(22)23)11-14-5-2-1-3-6-14/h1-8,12,16,18,21H,9-11,13,20H2,(H,22,23)(H,24,25)
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593n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
BindingDB Entry DOI: 10.7270/Q2CF9RQF
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50025049
PNG
(CHEMBL3355107)
Show SMILES Cc1cc(C)cc(CC(CP(O)(=O)C(N)CCc2ccccc2)C(O)=O)c1
Show InChI InChI=1S/C21H28NO4P/c1-15-10-16(2)12-18(11-15)13-19(21(23)24)14-27(25,26)20(22)9-8-17-6-4-3-5-7-17/h3-7,10-12,19-20H,8-9,13-14,22H2,1-2H3,(H,23,24)(H,25,26)
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1.03E+3n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
BindingDB Entry DOI: 10.7270/Q2CF9RQF
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM234297
PNG
(Met-ψ[P(O)(OH)CH2]-Ala (5))
Show SMILES CSCCC(N)P(O)(=O)CC(C)C(O)=O
Show InChI InChI=1S/C8H18NO4PS/c1-6(8(10)11)5-14(12,13)7(9)3-4-15-2/h6-7H,3-5,9H2,1-2H3,(H,10,11)(H,12,13)
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3.64E+3 -31.0n/an/an/an/an/a8.425



Academy of Sciences of the Czech Republic



Assay Description
LAP was assayed in 75 mM triethanolamine hydrochloride buffer (pH = 8.4, containing 5 mM MgCl2) at 25C. The substrate (L-leucine-p-nitroanilide) was...


J Enzyme Inhib Med Chem 26: 155-61 (2011)


Article DOI: 10.3109/14756366.2010.482047
BindingDB Entry DOI: 10.7270/Q22N515B
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170875
PNG
(CHEMBL3805288)
Show SMILES NC(CNCc1ccc(N)cc1)P(O)(O)=O
Show InChI InChI=1S/C9H16N3O3P/c10-8-3-1-7(2-4-8)5-12-6-9(11)16(13,14)15/h1-4,9,12H,5-6,10-11H2,(H2,13,14,15)
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7.02E+3n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM23983
PNG
(3-amino-N-hydroxy-1,2,3,4-tetrahydronaphthalene-2-...)
Show SMILES NC1Cc2ccccc2CC1C(=O)NO
Show InChI InChI=1S/C11H14N2O2/c12-10-6-8-4-2-1-3-7(8)5-9(10)11(14)13-15/h1-4,9-10,15H,5-6,12H2,(H,13,14)
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1.00E+4 -29.0n/an/an/an/an/a8.030



ENSCMu



Assay Description
Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...


Bioorg Med Chem 14: 7241-57 (2006)


Article DOI: 10.1016/j.bmc.2006.06.050
BindingDB Entry DOI: 10.7270/Q2N29V73
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170881
PNG
(CHEMBL3805028)
Show SMILES CC(C)CNCC(N)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H27N2O4P/c1-12(2)9-18-10-15(17)23(21,22)11-14(16(19)20)8-13-6-4-3-5-7-13/h3-7,12,14-15,18H,8-11,17H2,1-2H3,(H,19,20)(H,21,22)
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1.52E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170878
PNG
(CHEMBL3806197)
Show SMILES COc1ccc(CCNCC(N)P(O)(O)=O)cc1
Show InChI InChI=1S/C11H19N2O4P/c1-17-10-4-2-9(3-5-10)6-7-13-8-11(12)18(14,15)16/h2-5,11,13H,6-8,12H2,1H3,(H2,14,15,16)
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Similars

Article
PubMed
1.95E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170897
PNG
(CHEMBL3805573)
Show SMILES NC(CNC1CCCCCC1)P(O)(O)=O
Show InChI InChI=1S/C9H21N2O3P/c10-9(15(12,13)14)7-11-8-5-3-1-2-4-6-8/h8-9,11H,1-7,10H2,(H2,12,13,14)
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.08E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170880
PNG
(CHEMBL3806187)
Show SMILES CCCNCC(N)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C15H25N2O4P/c1-2-8-17-10-14(16)22(20,21)11-13(15(18)19)9-12-6-4-3-5-7-12/h3-7,13-14,17H,2,8-11,16H2,1H3,(H,18,19)(H,20,21)
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
2.10E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170884
PNG
(CHEMBL3805495)
Show SMILES COc1ccc(CCNCC(N)P(O)(=O)CC(Cc2ccccc2)C(O)=O)cc1
Show InChI InChI=1S/C21H29N2O5P/c1-28-19-9-7-16(8-10-19)11-12-23-14-20(22)29(26,27)15-18(21(24)25)13-17-5-3-2-4-6-17/h2-10,18,20,23H,11-15,22H2,1H3,(H,24,25)(H,26,27)
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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.11E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM234295
PNG
(Met-PH (2))
Show SMILES CSCCC(N)P(O)=O
Show InChI InChI=1S/C4H12NO2PS/c1-9-3-2-4(5)8(6)7/h4,8H,2-3,5H2,1H3,(H,6,7)
GoogleScholar
PC cid
PC sid
PDB
UniChem
Article
PubMed
2.20E+4 -26.6n/an/an/an/an/a8.425



Academy of Sciences of the Czech Republic



Assay Description
LAP was assayed in 75 mM triethanolamine hydrochloride buffer (pH = 8.4, containing 5 mM MgCl2) at 25C. The substrate (L-leucine-p-nitroanilide) was...


J Enzyme Inhib Med Chem 26: 155-61 (2011)


Article DOI: 10.3109/14756366.2010.482047
BindingDB Entry DOI: 10.7270/Q22N515B
More data for this
Ligand-Target Pair
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