BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2035 hits Enz. Inhib. hit(s) with Target = 'Potassium channel (ATP modulatory)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50505262
PNG
(CHEMBL4559408)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)N)C(=O)N[C@@H](CC(N)=O)C(=O)N2)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](NC1=O)[C@@H](C)CC)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C106H176N34O23S5/c1-11-56(6)83-103(161)138-84(57(7)12-2)104(162)139-85(58(8)13-3)105(163)140-40-25-33-79(140)102(160)132-72(44-61-48-117-54-121-61)96(154)127-69(34-41-164-10)92(150)134-76-51-167-168-52-77(135-94(152)70(42-55(4)5)128-87(145)59(9)111)100(158)131-74(46-81(113)142)98(156)136-78(101(159)130-73(45-80(112)141)97(155)126-68(93(151)137-83)32-24-39-118-106(115)116)53-166-165-50-75(88(146)120-49-82(143)122-65(29-17-21-36-108)89(147)123-64(86(114)144)28-16-20-35-107)133-91(149)67(31-19-23-38-110)124-90(148)66(30-18-22-37-109)125-95(153)71(129-99(76)157)43-60-47-119-63-27-15-14-26-62(60)63/h14-15,26-27,47-48,54-59,64-79,83-85,119H,11-13,16-25,28-46,49-53,107-111H2,1-10H3,(H2,112,141)(H2,113,142)(H2,114,144)(H,117,121)(H,120,146)(H,122,143)(H,123,147)(H,124,148)(H,125,153)(H,126,155)(H,127,154)(H,128,145)(H,129,157)(H,130,159)(H,131,158)(H,132,160)(H,133,149)(H,134,150)(H,135,152)(H,136,156)(H,137,151)(H,138,161)(H,139,162)(H4,115,116,118)/t56-,57-,58-,59-,64-,65-,66-,67-,68+,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,83-,84-,85-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
KEGG
PC cid
PC sid
UniChem
Article
PubMed
2n/an/an/an/an/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Inhibition of ROMK (unknown origin)


J Med Chem 62: 8682-8694 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01891
More data for this
Ligand-Target Pair
Potassium channel (ATP modulatory)


(GUINEA PIG)
BDBM86244
PNG
(A-312110)
Show SMILES Fc1ccc(cc1I)[C@@H]1C2C(=O)COCC2=NC2=C1S(=O)(=O)CC2
Show InChI InChI=1S/C16H13FINO4S/c17-9-2-1-8(5-10(9)18)14-15-12(6-23-7-13(15)20)19-11-3-4-24(21,22)16(11)14/h1-2,5,14-15H,3-4,6-7H2/t14-,15?/m1/s1
Reactome pathway

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Patents

Article
PubMed
4.90n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Mol Pharmacol 64: 143-53 (2003)


Article DOI: 10.1124/mol.64.1.143
BindingDB Entry DOI: 10.7270/Q22B8WMJ
More data for this
Ligand-Target Pair
Potassium channel (ATP modulatory)


(GUINEA PIG)
BDBM86250
PNG
(CAS_60559-98-0 | NSC_43345 | P1075)
Show SMILES CCC(C)(C)N=C(NC#N)Nc1cccnc1
Show InChI InChI=1S/C12H17N5/c1-4-12(2,3)17-11(15-9-13)16-10-6-5-7-14-8-10/h5-8H,4H2,1-3H3,(H2,15,16,17)
Reactome pathway

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
10.5n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Mol Pharmacol 64: 143-53 (2003)


Article DOI: 10.1124/mol.64.1.143
BindingDB Entry DOI: 10.7270/Q22B8WMJ
More data for this
Ligand-Target Pair
Potassium channel (ATP modulatory)


(GUINEA PIG)
BDBM86250
PNG
(CAS_60559-98-0 | NSC_43345 | P1075)
Show SMILES CCC(C)(C)N=C(NC#N)Nc1cccnc1
Show InChI InChI=1S/C12H17N5/c1-4-12(2,3)17-11(15-9-13)16-10-6-5-7-14-8-10/h5-8H,4H2,1-3H3,(H2,15,16,17)
Reactome pathway

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
10.7n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Br J Pharmacol 143: 81-90 (2004)


Article DOI: 10.1038/sj.bjp.0705908
BindingDB Entry DOI: 10.7270/Q2QR4VQ0
More data for this
Ligand-Target Pair
Potassium channel (ATP modulatory)


(GUINEA PIG)
BDBM86247
PNG
(BAY X 9228 | CAS_3038059 | NSC_3038059)
Show SMILES CCOc1ccccc1N=C(C[N+]([O-])=O)NC(C)C(C)(C)C
Show InChI InChI=1S/C16H25N3O3/c1-6-22-14-10-8-7-9-13(14)18-15(11-19(20)21)17-12(2)16(3,4)5/h7-10,12H,6,11H2,1-5H3,(H,17,18)
Reactome pathway

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
16n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Mol Pharmacol 64: 143-53 (2003)


Article DOI: 10.1124/mol.64.1.143
BindingDB Entry DOI: 10.7270/Q22B8WMJ
More data for this
Ligand-Target Pair
Potassium channel (ATP modulatory)


(GUINEA PIG)
BDBM86250
PNG
(CAS_60559-98-0 | NSC_43345 | P1075)
Show SMILES CCC(C)(C)N=C(NC#N)Nc1cccnc1
Show InChI InChI=1S/C12H17N5/c1-4-12(2,3)17-11(15-9-13)16-10-6-5-7-14-8-10/h5-8H,4H2,1-3H3,(H2,15,16,17)
Reactome pathway

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
20.6n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Mol Pharmacol 64: 143-53 (2003)


Article DOI: 10.1124/mol.64.1.143
BindingDB Entry DOI: 10.7270/Q22B8WMJ
More data for this
Ligand-Target Pair
Potassium channel (ATP modulatory)


(GUINEA PIG)
BDBM86247
PNG
(BAY X 9228 | CAS_3038059 | NSC_3038059)
Show SMILES CCOc1ccccc1N=C(C[N+]([O-])=O)NC(C)C(C)(C)C
Show InChI InChI=1S/C16H25N3O3/c1-6-22-14-10-8-7-9-13(14)18-15(11-19(20)21)17-12(2)16(3,4)5/h7-10,12H,6,11H2,1-5H3,(H,17,18)
Reactome pathway

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
41.3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Mol Pharmacol 64: 143-53 (2003)


Article DOI: 10.1124/mol.64.1.143
BindingDB Entry DOI: 10.7270/Q22B8WMJ
More data for this
Ligand-Target Pair
Potassium channel (ATP modulatory)


(GUINEA PIG)
BDBM86245
PNG
(CAS_85371-64-8 | NSC_4826 | PINACIDIL)
Show SMILES CC(N=C(NC#N)Nc1ccncc1)C(C)(C)C
Show InChI InChI=1S/C13H19N5/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11/h5-8,10H,1-4H3,(H2,15,16,17,18)
Reactome pathway

UniProtKB/TrEMBL

GoogleScholar
Purchase

PC cid
PC sid
UniChem

Patents

Article
PubMed
104n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Mol Pharmacol 64: 143-53 (2003)


Article DOI: 10.1124/mol.64.1.143
BindingDB Entry DOI: 10.7270/Q22B8WMJ
More data for this
Ligand-Target Pair
Potassium channel (ATP modulatory)


(GUINEA PIG)
BDBM86251
PNG
(CAS_94535-50-9 | CROMAKALIM (-) | NSC_93504)
Show SMILES CC1(C)Oc2ccc(cc2C(C1O)N1CCCC1=O)C#N
Show InChI InChI=1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3
Reactome pathway

UniProtKB/TrEMBL

GoogleScholar
Purchase

KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
157n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Mol Pharmacol 64: 143-53 (2003)


Article DOI: 10.1124/mol.64.1.143
BindingDB Entry DOI: 10.7270/Q22B8WMJ
More data for this
Ligand-Target Pair
Potassium channel (ATP modulatory)


(GUINEA PIG)
BDBM86245
PNG
(CAS_85371-64-8 | NSC_4826 | PINACIDIL)
Show SMILES CC(N=C(NC#N)Nc1ccncc1)C(C)(C)C
Show InChI InChI=1S/C13H19N5/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11/h5-8,10H,1-4H3,(H2,15,16,17,18)
Reactome pathway

UniProtKB/TrEMBL

GoogleScholar
Purchase

PC cid
PC sid
UniChem

Patents

Article
PubMed
251n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Mol Pharmacol 64: 143-53 (2003)


Article DOI: 10.1124/mol.64.1.143
BindingDB Entry DOI: 10.7270/Q22B8WMJ
More data for this
Ligand-Target Pair
Potassium channel (ATP modulatory)


(GUINEA PIG)
BDBM86249
PNG
(ZD 6169 | ZD-6169)
Show SMILES C[C@](O)(C(=O)Nc1ccc(cc1)C(=O)c1ccccc1)C(F)(F)F
Show InChI InChI=1S/C17H14F3NO3/c1-16(24,17(18,19)20)15(23)21-13-9-7-12(8-10-13)14(22)11-5-3-2-4-6-11/h2-10,24H,1H3,(H,21,23)/t16-/m0/s1
Reactome pathway

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
451n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Mol Pharmacol 64: 143-53 (2003)


Article DOI: 10.1124/mol.64.1.143
BindingDB Entry DOI: 10.7270/Q22B8WMJ
More data for this
Ligand-Target Pair
Potassium channel (ATP modulatory)


(GUINEA PIG)
BDBM86251
PNG
(CAS_94535-50-9 | CROMAKALIM (-) | NSC_93504)
Show SMILES CC1(C)Oc2ccc(cc2C(C1O)N1CCCC1=O)C#N
Show InChI InChI=1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3
Reactome pathway

UniProtKB/TrEMBL

GoogleScholar
Purchase

KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
542n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Mol Pharmacol 64: 143-53 (2003)


Article DOI: 10.1124/mol.64.1.143
BindingDB Entry DOI: 10.7270/Q22B8WMJ
More data for this
Ligand-Target Pair
Potassium channel (ATP modulatory)


(GUINEA PIG)
BDBM86249
PNG
(ZD 6169 | ZD-6169)
Show SMILES C[C@](O)(C(=O)Nc1ccc(cc1)C(=O)c1ccccc1)C(F)(F)F
Show InChI InChI=1S/C17H14F3NO3/c1-16(24,17(18,19)20)15(23)21-13-9-7-12(8-10-13)14(22)11-5-3-2-4-6-11/h2-10,24H,1H3,(H,21,23)/t16-/m0/s1
Reactome pathway

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
630n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Mol Pharmacol 64: 143-53 (2003)


Article DOI: 10.1124/mol.64.1.143
BindingDB Entry DOI: 10.7270/Q22B8WMJ
More data for this
Ligand-Target Pair
Potassium channel (ATP modulatory)


(GUINEA PIG)
BDBM86246
PNG
(zm244085)
Show SMILES O=C1CCCC2=NC3=C(C(C12)c1cccc(c1)C#N)C(=O)CCC3
Show InChI InChI=1S/C20H18N2O2/c21-11-12-4-1-5-13(10-12)18-19-14(6-2-8-16(19)23)22-15-7-3-9-17(24)20(15)18/h1,4-5,10,18-19H,2-3,6-9H2
Reactome pathway

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Patents

Article
PubMed
671n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Mol Pharmacol 64: 143-53 (2003)


Article DOI: 10.1124/mol.64.1.143
BindingDB Entry DOI: 10.7270/Q22B8WMJ
More data for this
Ligand-Target Pair
Renal Outer Medullary Potassium (ROMK)


(Rattus norvegicus (Rat))
BDBM82071
PNG
(CAS_93413-69-5 | CAS_99300-78-4 | NSC_62923 | VENL...)
Show SMILES COc1ccc(cc1)C(CN(C)C)C1(O)CCCCC1
Show InChI InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3
Reactome pathway

UniProtKB/SwissProt

GoogleScholar
Purchase

DrugBank
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.00E+3n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by PDSP Ki Database




Neuropsychopharmacology 25: 871-80 (2001)


Article DOI: 10.1016/S0893-133X(01)00298-6
BindingDB Entry DOI: 10.7270/Q25M648W
More data for this
Ligand-Target Pair
Renal Outer Medullary Potassium (ROMK)


(Rattus norvegicus (Rat))
BDBM84745
PNG
(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)
Show SMILES CNCC[C@H](Oc1cccc2ccccc12)c1cccs1
Show InChI InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1
Reactome pathway

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEBI
DrugBank
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
1.00E+3n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by PDSP Ki Database




Neuropsychopharmacology 25: 871-80 (2001)


Article DOI: 10.1016/S0893-133X(01)00298-6
BindingDB Entry DOI: 10.7270/Q25M648W
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50171290
PNG
(5-(4-Bromo-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl...)
Show SMILES CCc1c(nn(c1-c1ccc(Br)cc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1
Show InChI InChI=1S/C23H23BrCl2N4O/c1-2-18-21(23(31)28-29-12-4-3-5-13-29)27-30(20-11-10-17(25)14-19(20)26)22(18)15-6-8-16(24)9-7-15/h6-11,14H,2-5,12-13H2,1H3,(H,28,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.00E+3n/an/an/an/an/an/an/an/a



Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database




J Pharmacol Exp Ther 310: 905-14 (2004)


Article DOI: 10.1124/jpet.104.067884
BindingDB Entry DOI: 10.7270/Q2RR1WTX
More data for this
Ligand-Target Pair
Renal Outer Medullary Potassium (ROMK)


(Rattus norvegicus (Rat))
BDBM50022784
PNG
((R)-N-methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine...)
Show SMILES CNCCC(Oc1ccccc1C)c1ccccc1
Show InChI InChI=1S/C17H21NO/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15/h3-11,17-18H,12-13H2,1-2H3
Reactome pathway

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.00E+3n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by PDSP Ki Database




Neuropsychopharmacology 27: 699-711 (2002)


Article DOI: 10.1016/S0893-133X(02)00346-9
BindingDB Entry DOI: 10.7270/Q2GQ6W98
More data for this
Ligand-Target Pair
Potassium channel (ATP modulatory)


(GUINEA PIG)
BDBM86246
PNG
(zm244085)
Show SMILES O=C1CCCC2=NC3=C(C(C12)c1cccc(c1)C#N)C(=O)CCC3
Show InChI InChI=1S/C20H18N2O2/c21-11-12-4-1-5-13(10-12)18-19-14(6-2-8-16(19)23)22-15-7-3-9-17(24)20(15)18/h1,4-5,10,18-19H,2-3,6-9H2
Reactome pathway

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Patents

Article
PubMed
2.77E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Mol Pharmacol 64: 143-53 (2003)


Article DOI: 10.1124/mol.64.1.143
BindingDB Entry DOI: 10.7270/Q22B8WMJ
More data for this
Ligand-Target Pair
Potassium channel (ATP modulatory)


(GUINEA PIG)
BDBM86248
PNG
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)
Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
Reactome pathway

UniProtKB/TrEMBL

GoogleScholar
Purchase

CHEBI
KEGG
PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Mol Pharmacol 64: 143-53 (2003)


Article DOI: 10.1124/mol.64.1.143
BindingDB Entry DOI: 10.7270/Q22B8WMJ
More data for this
Ligand-Target Pair
Potassium channel (ATP modulatory)


(GUINEA PIG)
BDBM86248
PNG
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)
Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
Reactome pathway

UniProtKB/TrEMBL

GoogleScholar
Purchase

CHEBI
KEGG
PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Mol Pharmacol 64: 143-53 (2003)


Article DOI: 10.1124/mol.64.1.143
BindingDB Entry DOI: 10.7270/Q22B8WMJ
More data for this
Ligand-Target Pair
Renal Outer Medullary Potassium (ROMK)


(Rattus norvegicus (Rat))
BDBM50133817
PNG
(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)
Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2Cl)cc1
Show InChI InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)
Reactome pathway

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Pudue Pharma Discovery Research

Curated by PDSP Ki Database




J Pharmacol Exp Ther 306: 377-86 (2003)


Article DOI: 10.1124/jpet.102.045674
BindingDB Entry DOI: 10.7270/Q2TX3CX5
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM21280
PNG
(5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)met...)
Show SMILES Cc1ccc(Cn2nc(cc2-c2ccc(Cl)c(C)c2)C(=O)NC2[C@@]3(C)CCC(C3)C2(C)C)cc1
Show InChI InChI=1S/C29H34ClN3O/c1-18-6-8-20(9-7-18)17-33-25(21-10-11-23(30)19(2)14-21)15-24(32-33)26(34)31-27-28(3,4)22-12-13-29(27,5)16-22/h6-11,14-15,22,27H,12-13,16-17H2,1-5H3,(H,31,34)/t22?,27?,29-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Sanofi Recherche

Curated by PDSP Ki Database




J Pharmacol Exp Ther 284: 644-50 (1998)


BindingDB Entry DOI: 10.7270/Q2D50KHT
More data for this
Ligand-Target Pair
Renal Outer Medullary Potassium (ROMK)


(Rattus norvegicus (Rat))
BDBM50094703
PNG
(5-(3-Bromo-phenyl)-7-(6-morpholin-4-yl-pyridin-3-y...)
Show SMILES Nc1ncnc2nc(cc(-c3cccc(Br)c3)c12)-c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C22H19BrN6O/c23-16-3-1-2-14(10-16)17-11-18(28-22-20(17)21(24)26-13-27-22)15-4-5-19(25-12-15)29-6-8-30-9-7-29/h1-5,10-13H,6-9H2,(H2,24,26,27,28)
Reactome pathway

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




J Pharmacol Exp Ther 295: 1156-64 (2000)


BindingDB Entry DOI: 10.7270/Q2DF6PSP
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM456266
PNG
(((R)-1-(5-(((2-hydroxy-2- (4-methyl-1-oxo-1,3- dih...)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CNCc1ccc(nc1)-n1cc(cn1)C#N
Show InChI InChI=1S/C21H19N5O3/c1-13-16(3-4-17-18(13)12-29-21(17)28)19(27)10-23-7-14-2-5-20(24-8-14)26-11-15(6-22)9-25-26/h2-5,8-9,11,19,23,27H,7,10,12H2,1H3/t19-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.150n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2), 1 Mg...


US Patent US10723723 (2020)

More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM456266
PNG
(((R)-1-(5-(((2-hydroxy-2- (4-methyl-1-oxo-1,3- dih...)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CNCc1ccc(nc1)-n1cc(cn1)C#N
Show InChI InChI=1S/C21H19N5O3/c1-13-16(3-4-17-18(13)12-29-21(17)28)19(27)10-23-7-14-2-5-20(24-8-14)26-11-15(6-22)9-25-26/h2-5,8-9,11,19,23,27H,7,10,12H2,1H3/t19-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.570n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Solutions and reagents: Thallium flux assay was performed using FluxOR kit (F10017, Life Technologies). Loading buffer, assay buffer and stimulus buf...


US Patent US10723723 (2020)

More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM456149
PNG
(US10723723, Example 35)
Show SMILES COc1c(CNC[C@H](O)c2ccc3C(=O)OCc3c2C)cnn1-c1cc(C)c(cn1)C#N
Show InChI InChI=1S/C23H23N5O4/c1-13-6-21(26-9-15(13)7-24)28-22(31-3)16(10-27-28)8-25-11-20(29)17-4-5-18-19(14(17)2)12-32-23(18)30/h4-6,9-10,20,25,29H,8,11-12H2,1-3H3/t20-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Solutions and reagents: Thallium flux assay was performed using FluxOR kit (F10017, Life Technologies). Loading buffer, assay buffer and stimulus buf...


US Patent US10723723 (2020)

More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM456226
PNG
((R)-5'-(((2-hydroxy-2-(4- methyl-1-oxo-1,3- dihydr...)
Show SMILES COc1cc(ncc1C#N)-c1ccc(CNC[C@H](O)c2ccc3C(=O)OCc3c2C)cn1
Show InChI InChI=1S/C24H22N4O4/c1-14-17(4-5-18-19(14)13-32-24(18)30)22(29)12-26-9-15-3-6-20(27-10-15)21-7-23(31-2)16(8-25)11-28-21/h3-7,10-11,22,26,29H,9,12-13H2,1-2H3/t22-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2), 1 Mg...


US Patent US10723723 (2020)

More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM456268
PNG
((R)-1-(5-(((2-hydroxy-2- (4-methyl-1-oxo-1,3- dihy...)
Show SMILES Cc1nn(cc1C#N)-c1ccc(CNC[C@H](O)c2ccc3C(=O)OCc3c2C)cn1
Show InChI InChI=1S/C22H21N5O3/c1-13-17(4-5-18-19(13)12-30-22(18)29)20(28)10-24-8-15-3-6-21(25-9-15)27-11-16(7-23)14(2)26-27/h3-6,9,11,20,24,28H,8,10,12H2,1-2H3/t20-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2), 1 Mg...


US Patent US10723723 (2020)

More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM456260
PNG
((R)-6-(4-(((2-hydroxy-2- (4-methyl-1-oxo-1,3- dihy...)
Show SMILES COc1cc(ncc1C#N)-n1cc(CNC[C@H](O)c2ccc3C(=O)OCc3c2C)cn1
Show InChI InChI=1S/C22H21N5O4/c1-13-16(3-4-17-18(13)12-31-22(17)29)19(28)10-24-7-14-8-26-27(11-14)21-5-20(30-2)15(6-23)9-25-21/h3-5,8-9,11,19,24,28H,7,10,12H2,1-2H3/t19-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.40n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Solutions and reagents: Thallium flux assay was performed using FluxOR kit (F10017, Life Technologies). Loading buffer, assay buffer and stimulus buf...


US Patent US10723723 (2020)

More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM195013
PNG
(US9206198, 78 | US9206198, 79)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(CC(O)c3ccc4C(=O)OCc4c3Cl)CC2)C1=O
Show InChI InChI=1S/C23H25ClN2O6/c1-13-17(12-32-20(13)28)26-9-6-23(22(26)30)4-7-25(8-5-23)10-18(27)15-3-2-14-16(19(15)24)11-31-21(14)29/h2-3,18,27H,4-12H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/a7.437



Merck Sharp & Dohme Corp

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...


US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM265526
PNG
(US9718808, 44)
Show SMILES CC1=C(COC1=O)N1CC[C@@]2(CC[C@@H](CC2)NCc2ccc(cc2)-n2cnnn2)C1=O
Show InChI InChI=1S/C22H26N6O3/c1-15-19(13-31-20(15)29)27-11-10-22(21(27)30)8-6-17(7-9-22)23-12-16-2-4-18(5-3-16)28-14-24-25-26-28/h2-5,14,17,23H,6-13H2,1H3/t17-,22-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.10n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A Thallium Flux Assay was performed on each of the final product compounds of the Examples. This assay has been described previously; see, e.g., PCT ...


US Patent US9718808 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5HNG
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM265519
PNG
(US9718808, 41)
Show SMILES CC1=C(COC1=O)N1CC[C@@]2(CC[C@@H](CC2)NCc2ccc(cc2)-n2ncnn2)C1=O
Show InChI InChI=1S/C22H26N6O3/c1-15-19(13-31-20(15)29)27-11-10-22(21(27)30)8-6-17(7-9-22)23-12-16-2-4-18(5-3-16)28-25-14-24-26-28/h2-5,14,17,23H,6-13H2,1H3/t17-,22-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.30n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A Thallium Flux Assay was performed on each of the final product compounds of the Examples. This assay has been described previously; see, e.g., PCT ...


US Patent US9718808 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5HNG
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM266980
PNG
(US9718808, 109)
Show SMILES CN(Cc1ccc(cc1)-n1ncnn1)[C@H]1CC[C@@]2(CCN(C3=C(C)C(=O)OC3)C2=O)CC1
Show InChI InChI=1S/C23H28N6O3/c1-16-20(14-32-21(16)30)28-12-11-23(22(28)31)9-7-18(8-10-23)27(2)13-17-3-5-19(6-4-17)29-25-15-24-26-29/h3-6,15,18H,7-14H2,1-2H3/t18-,23-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.40n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A Thallium Flux Assay was performed on each of the final product compounds of the Examples. This assay has been described previously; see, e.g., PCT ...


US Patent US9718808 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5HNG
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM456264
PNG
((R)-3-(difluoromethoxy)- 1-(5-(((2-hydroxy-2-(4- m...)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CNCc1ccc(nc1)-n1cc(C#N)c(OC(F)F)n1
Show InChI InChI=1S/C22H19F2N5O4/c1-12-15(3-4-16-17(12)11-32-21(16)31)18(30)9-26-7-13-2-5-19(27-8-13)29-10-14(6-25)20(28-29)33-22(23)24/h2-5,8,10,18,22,26,30H,7,9,11H2,1H3/t18-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.60n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Solutions and reagents: Thallium flux assay was performed using FluxOR kit (F10017, Life Technologies). Loading buffer, assay buffer and stimulus buf...


US Patent US10723723 (2020)

More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM456268
PNG
((R)-1-(5-(((2-hydroxy-2- (4-methyl-1-oxo-1,3- dihy...)
Show SMILES Cc1nn(cc1C#N)-c1ccc(CNC[C@H](O)c2ccc3C(=O)OCc3c2C)cn1
Show InChI InChI=1S/C22H21N5O3/c1-13-17(4-5-18-19(13)12-30-22(18)29)20(28)10-24-8-15-3-6-21(25-9-15)27-11-16(7-23)14(2)26-27/h3-6,9,11,20,24,28H,8,10,12H2,1-2H3/t20-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.60n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Solutions and reagents: Thallium flux assay was performed using FluxOR kit (F10017, Life Technologies). Loading buffer, assay buffer and stimulus buf...


US Patent US10723723 (2020)

More data for this
Ligand-Target Pair
ATP-regulated potassium channel ROM-K


(Homo sapiens (Human))
BDBM363473
PNG
((S)-9-(2-(6-(1H-tetrazol-1- yl)pyridin-3-yl)-2-hyd...)
Show SMILES CC1=C(COC1=O)N1CCOC2(CCN(C[C@@H](O)c3ccc(nc3)-n3cnnn3)CC2)C1=O
Show InChI InChI=1S/C21H25N7O5/c1-14-16(12-32-19(14)30)27-8-9-33-21(20(27)31)4-6-26(7-5-21)11-17(29)15-2-3-18(22-10-15)28-13-23-24-25-28/h2-3,10,13,17,29H,4-9,11-12H2,1H3/t17-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.80n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...


US Patent US9850245 (2017)


BindingDB Entry DOI: 10.7270/Q2H70J3N
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM194963
PNG
(US9206198, 18)
Show SMILES CO[C@@H](CN1CC2CCC(C1)CC1(CCN(C3=CC(=O)OC3)C1=O)C2)c1ccc2C(=O)OCc2c1C
Show InChI InChI=1S/C28H34N2O6/c1-17-21(5-6-22-23(17)16-36-26(22)32)24(34-2)14-29-12-18-3-4-19(13-29)11-28(10-18)7-8-30(27(28)33)20-9-25(31)35-15-20/h5-6,9,18-19,24H,3-4,7-8,10-16H2,1-2H3/t18?,19?,24-,28?/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/a7.437



Merck Sharp & Dohme Corp

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...


US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM194967
PNG
(US9206198, 22)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCN(C2=O)C2=C(F)C(=O)OC2)CC1
Show InChI InChI=1S/C23H25FN2O6/c1-13-14(2-3-15-16(13)11-31-20(15)28)18(27)10-25-7-4-23(5-8-25)6-9-26(22(23)30)17-12-32-21(29)19(17)24/h2-3,18,27H,4-12H2,1H3/t18-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/a7.437



Merck Sharp & Dohme Corp

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...


US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50249205
PNG
(CHEMBL4062753)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCN(C2=O)c2ccns2)CC1
Show InChI InChI=1S/C22H25N3O4S/c1-14-15(2-3-16-17(14)13-29-20(16)27)18(26)12-24-9-5-22(6-10-24)7-11-25(21(22)28)19-4-8-23-30-19/h2-4,8,18,26H,5-7,9-13H2,1H3/t18-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4n/an/an/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Inhibition of human ROMK expressed in CHO cells at -70 mV holding potential after 6 mins by whole cell patch clamp Qpatch method


Bioorg Med Chem Lett 27: 2559-2566 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.086
BindingDB Entry DOI: 10.7270/Q2BV7K1G
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM456277
PNG
(6-(4-(((1-hydroxy-1-(4- methyl-1-oxo-1,3- dihydroi...)
Show SMILES CC(NCc1cnn(c1)-c1cc(C)c(cn1)C#N)C(O)c1ccc2C(=O)OCc2c1C
Show InChI InChI=1S/C23H23N5O3/c1-13-6-21(26-10-17(13)7-24)28-11-16(9-27-28)8-25-15(3)22(29)18-4-5-19-20(14(18)2)12-31-23(19)30/h4-6,9-11,15,22,25,29H,8,12H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Solutions and reagents: Thallium flux assay was performed using FluxOR kit (F10017, Life Technologies). Loading buffer, assay buffer and stimulus buf...


US Patent US10723723 (2020)

More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM194951
PNG
(US9206198, 5)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCN(C3=CC(=O)OC3)C2=O)CC1
Show InChI InChI=1S/C23H26N2O6/c1-14-16(2-3-17-18(14)13-31-21(17)28)19(26)11-24-7-4-23(5-8-24)6-9-25(22(23)29)15-10-20(27)30-12-15/h2-3,10,19,26H,4-9,11-13H2,1H3/t19-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/a7.437



Merck Sharp & Dohme Corp

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...


US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM265547
PNG
(US9718808, 51)
Show SMILES CC1=C(COC1=O)N1CC[C@@]2(CC[C@@H](CC2)NCc2ccc-3c(CCc4nnnn-34)c2)C1=O
Show InChI InChI=1S/C24H28N6O3/c1-15-20(14-33-22(15)31)29-11-10-24(23(29)32)8-6-18(7-9-24)25-13-16-2-4-19-17(12-16)3-5-21-26-27-28-30(19)21/h2,4,12,18,25H,3,5-11,13-14H2,1H3/t18-,24-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.30n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A Thallium Flux Assay was performed on each of the final product compounds of the Examples. This assay has been described previously; see, e.g., PCT ...


US Patent US9718808 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5HNG
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM456141
PNG
(US10723723, Example 7-I | US10723723, Example 7-II)
Show SMILES Cc1cc(ncc1C#N)-n1cc(CNCC(O)c2ccc3C(=O)OCc3c2C)cn1
Show InChI InChI=1S/C22H21N5O3/c1-13-5-21(25-9-16(13)6-23)27-11-15(8-26-27)7-24-10-20(28)17-3-4-18-19(14(17)2)12-30-22(18)29/h3-5,8-9,11,20,24,28H,7,10,12H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.70n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2), 1 Mg...


US Patent US10723723 (2020)

More data for this
Ligand-Target Pair
ATP-regulated potassium channel ROMK


(Homo sapiens (Human))
BDBM338554
PNG
(US9751881, Example 83)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCN(C2)c2cnc(cn2)C#N)CC1
Show InChI InChI=1S/C24H27N5O3/c1-16-18(2-3-19-20(16)14-32-23(19)31)21(30)13-28-7-4-24(5-8-28)6-9-29(15-24)22-12-26-17(10-25)11-27-22/h2-3,11-12,21,30H,4-9,13-15H2,1H3/t21-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.70n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Assay Protocol: The ROMK channel functional thallium flux assay was performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells were ...


US Patent US9751881 (2017)


BindingDB Entry DOI: 10.7270/Q26M38ZP
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM423209
PNG
((R)-4-methyl-5-(4-((6- (4-methyl-1H-imidazol- 1-yl...)
Show SMILES Cc1cn(cn1)-c1ccc(CN2CCN[C@@H](C2)c2ccc3C(=O)OCc3c2C)cn1
Show InChI InChI=1S/C23H25N5O2/c1-15-10-28(14-26-15)22-6-3-17(9-25-22)11-27-8-7-24-21(12-27)18-4-5-19-20(16(18)2)13-30-23(19)29/h3-6,9-10,14,21,24H,7-8,11-13H2,1-2H3/t21-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.70n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2, 1 MgC...


US Patent US10501449 (2019)


BindingDB Entry DOI: 10.7270/Q2M32Z4C
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM423206
PNG
((R)-4-methoxy-6-(4- ((3-(4-methyl-1-oxo-1,3- dihyd...)
Show SMILES COc1cc(ncc1C#N)-n1cc(CN2CCN[C@@H](C2)c2ccc3C(=O)OCc3c2C)cn1
Show InChI InChI=1S/C24H24N6O3/c1-15-18(3-4-19-20(15)14-33-24(19)31)21-13-29(6-5-26-21)11-16-9-28-30(12-16)23-7-22(32-2)17(8-25)10-27-23/h3-4,7,9-10,12,21,26H,5-6,11,13-14H2,1-2H3/t21-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.80n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2, 1 MgC...


US Patent US10501449 (2019)


BindingDB Entry DOI: 10.7270/Q2M32Z4C
More data for this
Ligand-Target Pair
ATP-regulated potassium channel ROM-K


(Homo sapiens (Human))
BDBM363475
PNG
(9-(2-(4-(1H-tetrazol-1- yl)phenyl)-2-hydroxyethyl)...)
Show SMILES CC1=C(COC1=O)N1CCOC2(CCN(CC(O)c3ccc(cc3)-n3cnnn3)CC2)C1=O
Show InChI InChI=1S/C22H26N6O5/c1-15-18(13-32-20(15)30)27-10-11-33-22(21(27)31)6-8-26(9-7-22)12-19(29)16-2-4-17(5-3-16)28-14-23-24-25-28/h2-5,14,19,29H,6-13H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.80n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...


US Patent US9850245 (2017)


BindingDB Entry DOI: 10.7270/Q2H70J3N
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM423204
PNG
(US10501449, Example 23-I | US10501449, Example 255...)
Show SMILES Cc1cc(ncc1C#N)-n1cc(CN2CCN[C@@H](C2)c2ccc3C(=O)OCc3c2C)nn1
Show InChI InChI=1S/C23H23N7O2/c1-14-7-22(26-9-16(14)8-24)30-11-17(27-28-30)10-29-6-5-25-21(12-29)18-3-4-19-20(15(18)2)13-32-23(19)31/h3-4,7,9,11,21,25H,5-6,10,12-13H2,1-2H3/t21-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.90n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2, 1 MgC...


US Patent US10501449 (2019)


BindingDB Entry DOI: 10.7270/Q2M32Z4C
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50249244
PNG
(CHEMBL4103004)
Show SMILES COc1nccc(n1)N1CCC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C1=O
Show InChI InChI=1S/C24H28N4O5/c1-15-16(3-4-17-18(15)14-33-21(17)30)19(29)13-27-10-6-24(7-11-27)8-12-28(22(24)31)20-5-9-25-23(26-20)32-2/h3-5,9,19,29H,6-8,10-14H2,1-2H3/t19-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5n/an/an/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Inhibition of human ROMK expressed in CHO cells at -70 mV holding potential after 6 mins by whole cell patch clamp Qpatch method


Bioorg Med Chem Lett 27: 2559-2566 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.086
BindingDB Entry DOI: 10.7270/Q2BV7K1G
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 2035 total )  |  Next  |  Last  >>
Jump to: