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Found 19 Enz. Inhib. hit(s) with all data for entry = 2754
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM378893(5,8-dichloro-2-((7-methyl-5-oxo-5,6-dihydro-1H-pyr...)
Affinity DataIC50: <0.5nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM378912(5,8-dichloro-7-[methoxy(oxetan-3-yl)methyl]-2-[(7-...)
Affinity DataIC50:  1nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM378914(5,8-dichloro-2-[(7-methyl-5-oxo-1,6-dihydropyrrolo...)
Affinity DataIC50:  2nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM378913(7-((5,8-dichloro-7-((1,1-dioxidothietan-3-yl)(meth...)
Affinity DataIC50:  2nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM378909(5,8-dichloro-7-(3,5-dimethyltriazol-4-yl)-2-[(7-me...)
Affinity DataIC50:  2nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM378907(5,8-dichloro-7-(3,5-dimethylisoxazol-4-yl)-2-((7-m...)
Affinity DataIC50:  2nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM378911(7-((5,8-dichloro-7-(3,5-dimethylisoxazol-4-yl)-1-o...)
Affinity DataIC50:  3nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM378899(7-[[5-bromo-8-chloro-7-(3,5-dimethyltriazol-4-yl)-...)
Affinity DataIC50:  3nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM378903(7-((5,8-dichloro-7-(methoxy(oxetan-3-yl)methyl)-1-...)
Affinity DataIC50:  4nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM378891(7-((5,8-dichloro-7-(ethyl(tetrahydro-2H-pyran-4-yl...)
Affinity DataIC50:  5nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM378886(7-((5,8-dichloro-1-oxo-7-(7-oxa-2-azaspiro[3.5]non...)
Affinity DataIC50:  5nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM378861(7-((5,8-dichloro-7-isopropoxy-1-oxo-3,4-dihydroiso...)
Affinity DataIC50:  6nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM378895(7-((8-chloro-7-isopropoxy-1-oxo-3,4-dihydroisoquin...)
Affinity DataIC50:  7nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM378908(7-((5,8-dichloro-7-(1,4-dimethyl-1H-1,2,3-triazol-...)
Affinity DataIC50:  10nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM378905(5,8-dichloro-7-(methoxy(1-methylazetidin-3-yl)meth...)
Affinity DataIC50:  10nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM378904(7-((5,8-dichloro-7-(methoxy(1-methylazetidin-3-yl)...)
Affinity DataIC50:  12nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM378905(5,8-dichloro-7-(methoxy(1-methylazetidin-3-yl)meth...)
Affinity DataIC50:  37nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM378901(7-((5,8-dichloro-7-isopropoxy-1-oxo-3,4-dihydroiso...)
Affinity DataIC50:  95nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM378892(5,8-dichloro-7-isopropoxy-2-((7-methyl-5-oxo-5,6-d...)
Affinity DataIC50:  202nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent