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Found 6 Enz. Inhib. hit(s) with all data for entry = 9347
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408663((R)-5-cyano-N-(1-(2-hydroxy-2-(4-methyl-1-oxo-1,3-...)
Affinity DataIC50:  18.7nMAssay Description:human ROMK and rat ROMK: 1. Materials and Instruments (1) FluxOR potassium ion channel assay (F10016, Invitrogen) (2) Ouabain (03125-1G, Sigma)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408664((R)-5-cyano-4-ethoxy-N-(1-(2-hydroxy-2-(4-methyl-1...)
Affinity DataIC50:  28nMAssay Description:human ROMK and rat ROMK: 1. Materials and Instruments (1) FluxOR potassium ion channel assay (F10016, Invitrogen) (2) Ouabain (03125-1G, Sigma)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408663((R)-5-cyano-N-(1-(2-hydroxy-2-(4-methyl-1-oxo-1,3-...)
Affinity DataIC50:  40nMAssay Description:human ROMK and rat ROMK: 1. Materials and Instruments (1) FluxOR potassium ion channel assay (F10016, Invitrogen) (2) Ouabain (03125-1G, Sigma)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408664((R)-5-cyano-4-ethoxy-N-(1-(2-hydroxy-2-(4-methyl-1...)
Affinity DataIC50:  89nMAssay Description:human ROMK and rat ROMK: 1. Materials and Instruments (1) FluxOR potassium ion channel assay (F10016, Invitrogen) (2) Ouabain (03125-1G, Sigma)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408663((R)-5-cyano-N-(1-(2-hydroxy-2-(4-methyl-1-oxo-1,3-...)
Affinity DataIC50:  192nMAssay Description:human ROMK and rat ROMK: 1. Materials and Instruments (1) FluxOR potassium ion channel assay (F10016, Invitrogen) (2) Ouabain (03125-1G, Sigma)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408663((R)-5-cyano-N-(1-(2-hydroxy-2-(4-methyl-1-oxo-1,3-...)
Affinity DataIC50:  4.37E+4nMAssay Description:hERG: 1. Materials and Instruments (1) FluxOR potassium ion channel assay (F10016, invitrogen) (2) FlexStation3 microplate reader (molecular de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent