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Patent code US10780092

Compile Data Set for Download or QSAR
Found 156 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463151
PNG
(4-Amino-5-(4-chloro-3-fluoro-5- hydroxyphenyl)-2-{...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1)c1cc(O)c(Cl)c(F)c1
Show InChI InChI=1S/C26H18ClF2N7O2/c1-26(13-9-15(29)20(27)18(37)10-13)19-21(30)33-22(34-23(19)35-25(26)38)17-11-36-6-5-31-24(36)16(32-17)8-12-3-2-4-14(28)7-12/h2-7,9-11,37H,8H2,1H3,(H3,30,33,34,35,38)
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0.0910n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463152
PNG
(4-Amino-5-(4-chloro-3-fluoro-5- hydroxyphenyl)-2-{...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)ccc2F)n1)c1cc(O)c(Cl)c(F)c1
Show InChI InChI=1S/C26H17ClF3N7O2/c1-26(12-8-15(30)20(27)18(38)9-12)19-21(31)34-22(35-23(19)36-25(26)39)17-10-37-5-4-32-24(37)16(33-17)7-11-6-13(28)2-3-14(11)29/h2-6,8-10,38H,7H2,1H3,(H3,31,34,35,36,39)
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0.0940n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463148
PNG
(4-Amino-5-(4-chloro-3-fluoro-5-hydroxyphenyl)-2-{8...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1cc(O)c(Cl)c(F)c1
Show InChI InChI=1S/C26H18ClF2N7O2/c1-26(13-9-15(29)20(27)18(37)10-13)19-21(30)33-22(34-23(19)35-25(26)38)17-11-36-7-6-31-24(36)16(32-17)8-12-4-2-3-5-14(12)28/h2-7,9-11,37H,8H2,1H3,(H3,30,33,34,35,38)
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0.0950n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463147
PNG
(4-Amino-5-(4-chloro-3-hydroxyphenyl)-2-{8-[(3-fluo...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C26H19ClFN7O2/c1-26(14-5-6-16(27)19(36)11-14)20-21(29)32-22(33-23(20)34-25(26)37)18-12-35-8-7-30-24(35)17(31-18)10-13-3-2-4-15(28)9-13/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37)
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0.0950n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463153
PNG
(4-Amino-5-(4-chloro-3-fluoro-5- hydroxyphenyl)-5-m...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2F)n1)c1cc(O)c(Cl)c(F)c1
Show InChI InChI=1S/C26H16ClF4N7O2/c1-26(11-6-13(29)19(27)17(39)7-11)18-21(32)35-22(36-23(18)37-25(26)40)16-9-38-3-2-33-24(38)15(34-16)5-10-4-12(28)8-14(30)20(10)31/h2-4,6-9,39H,5H2,1H3,(H3,32,35,36,37,40)
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0.0980n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463154
PNG
(4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-{8-[(2- fl...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C26H19ClFN7O2/c1-26(14-6-7-15(27)19(36)11-14)20-21(29)32-22(33-23(20)34-25(26)37)18-12-35-9-8-30-24(35)17(31-18)10-13-4-2-3-5-16(13)28/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37)
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0.117n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463248
PNG
(4-(4-Amino-5-methyl-6-oxo-2- {8-[(2,3,5- trifluoro...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2F)n1)c1cc(O)c(C#N)c(F)c1
Show InChI InChI=1S/C27H16F4N8O2/c1-27(12-6-15(29)14(9-32)19(40)7-12)20-22(33)36-23(37-24(20)38-26(27)41)18-10-39-3-2-34-25(39)17(35-18)5-11-4-13(28)8-16(30)21(11)31/h2-4,6-8,10,40H,5H2,1H3,(H3,33,36,37,38,41)
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0.118n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463155
PNG
(4-Amino-5-(3,4-difluoro-5- hydroxyphenyl)-2-{8-[(2...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1cc(O)c(F)c(F)c1
Show InChI InChI=1S/C26H18F3N7O2/c1-26(13-9-15(28)20(29)18(37)10-13)19-21(30)33-22(34-23(19)35-25(26)38)17-11-36-7-6-31-24(36)16(32-17)8-12-4-2-3-5-14(12)27/h2-7,9-11,37H,8H2,1H3,(H3,30,33,34,35,38)
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0.126n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463156
PNG
(4-Amino-5-(4-chloro-3-fluoro-5- hydroxyphenyl)-2-{...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(Cc2ccccc2F)n1)c1cc(O)c(Cl)c(F)c1
Show InChI InChI=1S/C25H17ClF2N8O2/c1-25(12-7-14(28)19(26)17(37)8-12)18-20(29)33-21(34-22(18)35-24(25)38)16-9-36-23(30-10-31-36)15(32-16)6-11-4-2-3-5-13(11)27/h2-5,7-10,37H,6H2,1H3,(H3,29,33,34,35,38)
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0.128n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463157
PNG
(4-Amino-2-{8-[(2,5- difluorophenyl)methyl]imidazo[...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)ccc2F)n1)c1cccc(O)c1
Show InChI InChI=1S/C26H19F2N7O2/c1-26(14-3-2-4-16(36)11-14)20-21(29)32-22(33-23(20)34-25(26)37)19-12-35-8-7-30-24(35)18(31-19)10-13-9-15(27)5-6-17(13)28/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37)
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0.135n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463240
PNG
(4-Amino-5-(5-chloro-4- hydroxypyridin-2-yl)-2-{8-[...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)ccc2F)n1)c1cc(O)c(Cl)cn1
Show InChI InChI=1S/C25H17ClF2N8O2/c1-25(18-8-17(37)13(26)9-31-18)19-20(29)33-21(34-22(19)35-24(25)38)16-10-36-5-4-30-23(36)15(32-16)7-11-6-12(27)2-3-14(11)28/h2-6,8-10H,7H2,1H3,(H,31,37)(H3,29,33,34,35,38)
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0.149n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463158
PNG
(4-Amino-5-(4-chloro-3-fluoro-5- hydroxyphenyl)-2-(...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCCC2)n1)c1cc(O)c(Cl)c(F)c1
Show InChI InChI=1S/C26H25ClFN7O2/c1-26(14-10-15(28)20(27)18(36)11-14)19-21(29)32-22(33-23(19)34-25(26)37)17-12-35-8-7-30-24(35)16(31-17)9-13-5-3-2-4-6-13/h7-8,10-13,36H,2-6,9H2,1H3,(H3,29,32,33,34,37)
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0.153n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463159
PNG
(4-Amino-5-(4-fluoro-3- hydroxyphenyl)-2-{8-[(2- fl...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1ccc(F)c(O)c1
Show InChI InChI=1S/C26H19F2N7O2/c1-26(14-6-7-16(28)19(36)11-14)20-21(29)32-22(33-23(20)34-25(26)37)18-12-35-9-8-30-24(35)17(31-18)10-13-4-2-3-5-15(13)27/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37)
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0.154n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463302
PNG
(4-Amino-2-{8-(3-fluorobenzyl)imidazo[1,2-a]pyrazin...)
Show SMILES Cc1cnc(cc1O)C1(C)C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1
Show InChI InChI=1S/C26H21FN8O2/c1-13-11-30-19(10-18(13)36)26(2)20-21(28)32-22(33-23(20)34-25(26)37)17-12-35-7-6-29-24(35)16(31-17)9-14-4-3-5-15(27)8-14/h3-8,10-12H,9H2,1-2H3,(H,30,36)(H3,28,32,33,34,37)
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0.155n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463160
PNG
(4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-(8- (cyclo...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCCC2)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C26H26ClN7O2/c1-26(15-7-8-16(27)19(35)12-15)20-21(28)31-22(32-23(20)33-25(26)36)18-13-34-10-9-29-24(34)17(30-18)11-14-5-3-2-4-6-14/h7-10,12-14,35H,2-6,11H2,1H3,(H3,28,31,32,33,36)
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0.156n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463162
PNG
(4-Amino-5-(4-chloro-3-fluoro-5- hydroxyphenyl)-2-{...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2)n1)c1cc(O)c(Cl)c(F)c1
Show InChI InChI=1S/C26H17ClF3N7O2/c1-26(12-7-15(30)20(27)18(38)8-12)19-21(31)34-22(35-23(19)36-25(26)39)17-10-37-3-2-32-24(37)16(33-17)6-11-4-13(28)9-14(29)5-11/h2-5,7-10,38H,6H2,1H3,(H3,31,34,35,36,39)
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0.158n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463161
PNG
(4-(4-Amino-2-(8- (cyclohexylmethyl)- [1,2,4]triazo...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CC2CCCCC2)n1)c1cc(O)c(C#N)c(F)c1
Show InChI InChI=1S/C26H24FN9O2/c1-26(14-8-16(27)15(10-28)19(37)9-14)20-21(29)33-22(34-23(20)35-25(26)38)18-11-36-24(30-12-31-36)17(32-18)7-13-5-3-2-4-6-13/h8-9,11-13,37H,2-7H2,1H3,(H3,29,33,34,35,38)
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0.158n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463247
PNG
(4-(4-Amino-2-{8-[(2,5- difluorophenyl)methyl]imida...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)ccc2F)n1)c1cc(O)c(C#N)c(F)c1
Show InChI InChI=1S/C27H17F3N8O2/c1-27(13-8-17(30)15(10-31)20(39)9-13)21-22(32)35-23(36-24(21)37-26(27)40)19-11-38-5-4-33-25(38)18(34-19)7-12-6-14(28)2-3-16(12)29/h2-6,8-9,11,39H,7H2,1H3,(H3,32,35,36,37,40)
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0.162n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463163
PNG
(4-Amino-2-{8-[(3- fluorophenyl)methyl]imidazo[1,2-...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1)c1ccc(c(O)c1)C(F)(F)F
Show InChI InChI=1S/C27H19F4N7O2/c1-26(14-5-6-16(19(39)11-14)27(29,30)31)20-21(32)35-22(36-23(20)37-25(26)40)18-12-38-8-7-33-24(38)17(34-18)10-13-3-2-4-15(28)9-13/h2-9,11-12,39H,10H2,1H3,(H3,32,35,36,37,40)
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0.163n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463164
PNG
(4-(4-Amino-2-(8- (cyclohexylmethyl)imidazo[1,2- a]...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCCC2)n1)c1cc(O)c(C#N)c(F)c1
Show InChI InChI=1S/C27H25FN8O2/c1-27(15-10-17(28)16(12-29)20(37)11-15)21-22(30)33-23(34-24(21)35-26(27)38)19-13-36-8-7-31-25(36)18(32-19)9-14-5-3-2-4-6-14/h7-8,10-11,13-14,37H,2-6,9H2,1H3,(H3,30,33,34,35,38)
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0.168n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463165
PNG
(4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-{8-[(2,5- ...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)ccc2F)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C26H18ClF2N7O2/c1-26(13-2-4-15(27)19(37)10-13)20-21(30)33-22(34-23(20)35-25(26)38)18-11-36-7-6-31-24(36)17(32-18)9-12-8-14(28)3-5-16(12)29/h2-8,10-11,37H,9H2,1H3,(H3,30,33,34,35,38)
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0.170n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463166
PNG
(4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-{8-[(3,4- ...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccc(F)c(F)c2)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C26H18ClF2N7O2/c1-26(13-3-4-14(27)19(37)10-13)20-21(30)33-22(34-23(20)35-25(26)38)18-11-36-7-6-31-24(36)17(32-18)9-12-2-5-15(28)16(29)8-12/h2-8,10-11,37H,9H2,1H3,(H3,30,33,34,35,38)
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0.173n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463249
PNG
(4-Amino-5-(5-chloro-4- hydroxypyridin-2-yl)-5-meth...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2F)n1)c1cc(O)c(Cl)cn1
Show InChI InChI=1S/C25H16ClF3N8O2/c1-25(17-7-16(38)12(26)8-32-17)18-20(30)34-21(35-22(18)36-24(25)39)15-9-37-3-2-31-23(37)14(33-15)5-10-4-11(27)6-13(28)19(10)29/h2-4,6-9H,5H2,1H3,(H,32,38)(H3,30,34,35,36,39)
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0.175n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463237
PNG
(4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-{8-[(2,4- ...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2F)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C26H18ClF2N7O2/c1-26(13-3-5-15(27)19(37)9-13)20-21(30)33-22(34-23(20)35-25(26)38)18-11-36-7-6-31-24(36)17(32-18)8-12-2-4-14(28)10-16(12)29/h2-7,9-11,37H,8H2,1H3,(H3,30,33,34,35,38)
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0.199n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463167
PNG
(4-Amino-5-(4-chloro-3-fluoro-5- hydroxyphenyl)-2-(...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CC2CCCCC2)n1)c1cc(O)c(Cl)c(F)c1
Show InChI InChI=1S/C25H24ClFN8O2/c1-25(13-8-14(27)19(26)17(36)9-13)18-20(28)32-21(33-22(18)34-24(25)37)16-10-35-23(29-11-30-35)15(31-16)7-12-5-3-2-4-6-12/h8-12,36H,2-7H2,1H3,(H3,28,32,33,34,37)
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0.206n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463251
PNG
(4-Amino-5-(5-chloro-4- hydroxypyridin-2-yl)-2-(8- ...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CC2CCCCC2)n1)c1cc(O)c(Cl)cn1
Show InChI InChI=1S/C24H24ClN9O2/c1-24(17-8-16(35)13(25)9-27-17)18-19(26)31-20(32-21(18)33-23(24)36)15-10-34-22(28-11-29-34)14(30-15)7-12-5-3-2-4-6-12/h8-12H,2-7H2,1H3,(H,27,35)(H3,26,31,32,33,36)
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0.213n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463168
PNG
(4-Amino-2-{8-[(2,4- difluorophenyl)methyl]imidazo[...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2F)n1)c1ccc(F)c(O)c1
Show InChI InChI=1S/C26H18F3N7O2/c1-26(13-3-5-15(28)19(37)9-13)20-21(30)33-22(34-23(20)35-25(26)38)18-11-36-7-6-31-24(36)17(32-18)8-12-2-4-14(27)10-16(12)29/h2-7,9-11,37H,8H2,1H3,(H3,30,33,34,35,38)
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0.214n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463169
PNG
(4-(4-Amino-2-{8-[(2- fluorophenyl)methyl]imidazo[1...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1cc(O)c(C#N)c(F)c1
Show InChI InChI=1S/C27H18F2N8O2/c1-27(14-9-17(29)15(11-30)20(38)10-14)21-22(31)34-23(35-24(21)36-26(27)39)19-12-37-7-6-32-25(37)18(33-19)8-13-4-2-3-5-16(13)28/h2-7,9-10,12,38H,8H2,1H3,(H3,31,34,35,36,39)
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0.216n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463149
PNG
(4-Amino-2-{8-[(2-fluorophenyl)methyl]imidazo[1,2-a...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1ccc(c(O)c1)C(F)(F)F
Show InChI InChI=1S/C27H19F4N7O2/c1-26(14-6-7-15(19(39)11-14)27(29,30)31)20-21(32)35-22(36-23(20)37-25(26)40)18-12-38-9-8-33-24(38)17(34-18)10-13-4-2-3-5-16(13)28/h2-9,11-12,39H,10H2,1H3,(H3,32,35,36,37,40)
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0.219n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463253
PNG
(4-Amino-2-{8-[(3-fluorophenyl)methyl]imidazo[1,2-a...)
Show SMILES Cc1ccc(cc1O)C1(C)C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1
Show InChI InChI=1S/C27H22FN7O2/c1-14-6-7-16(12-20(14)36)27(2)21-22(29)32-23(33-24(21)34-26(27)37)19-13-35-9-8-30-25(35)18(31-19)11-15-4-3-5-17(28)10-15/h3-10,12-13,36H,11H2,1-2H3,(H3,29,32,33,34,37)
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0.221n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463170
PNG
(4-Amino-5-(3-fluoro-4- hydroxyphenyl)-2-{8-[(2- fl...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1ccc(O)c(F)c1
Show InChI InChI=1S/C26H19F2N7O2/c1-26(14-6-7-19(36)16(28)11-14)20-21(29)32-22(33-23(20)34-25(26)37)18-12-35-9-8-30-24(35)17(31-18)10-13-4-2-3-5-15(13)27/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37)
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0.241n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463171
PNG
(4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-(8- isopen...)
Show SMILES CC(C)CCc1nc(cn2ccnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C24H24ClN7O2/c1-12(2)4-7-15-22-27-8-9-32(22)11-16(28-15)20-29-19(26)18-21(30-20)31-23(34)24(18,3)13-5-6-14(25)17(33)10-13/h5-6,8-12,33H,4,7H2,1-3H3,(H3,26,29,30,31,34)
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0.252n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463150
PNG
(4-Amino-5-(5-chloro-4-hydroxypyridin-2-yl)-2-{8-[(...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1cc(O)c(Cl)cn1
Show InChI InChI=1S/C25H18ClFN8O2/c1-25(18-9-17(36)13(26)10-30-18)19-20(28)32-21(33-22(19)34-24(25)37)16-11-35-7-6-29-23(35)15(31-16)8-12-4-2-3-5-14(12)27/h2-7,9-11H,8H2,1H3,(H,30,36)(H3,28,32,33,34,37)
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0.259n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463299
PNG
(4-amino-5-(5-chloro- 4-hydroxypyridin-2- yl)-2-{8-...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(Cc2ccccc2F)n1)c1cc(O)c(Cl)cn1
Show InChI InChI=1S/C24H17ClFN9O2/c1-24(17-7-16(36)12(25)8-28-17)18-19(27)32-20(33-21(18)34-23(24)37)15-9-35-22(29-10-30-35)14(31-15)6-11-4-2-3-5-13(11)26/h2-5,7-10H,6H2,1H3,(H,28,36)(H3,27,32,33,34,37)
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0.261n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463177
PNG
(4-Amino-2-{8-[(4- fluorophenyl)methyl]imidazo[1,2-...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2)n1)c1cccc(O)c1
Show InChI InChI=1S/C26H20FN7O2/c1-26(15-3-2-4-17(35)12-15)20-21(28)31-22(32-23(20)33-25(26)36)19-13-34-10-9-29-24(34)18(30-19)11-14-5-7-16(27)8-6-14/h2-10,12-13,35H,11H2,1H3,(H3,28,31,32,33,36)
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0.274n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463172
PNG
(4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-{8-[(4- fl...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(Cc2ccc(F)cc2)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C25H18ClFN8O2/c1-25(13-4-7-15(26)18(36)9-13)19-20(28)32-21(33-22(19)34-24(25)37)17-10-35-23(29-11-30-35)16(31-17)8-12-2-5-14(27)6-3-12/h2-7,9-11,36H,8H2,1H3,(H3,28,32,33,34,37)
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0.276n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463173
PNG
(4-(4-Amino-2-{8-[(3,5- difluorophenyl)methyl]- [1,...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(Cc2cc(F)cc(F)c2)n1)c1cc(O)c(C#N)c(F)c1
Show InChI InChI=1S/C26H16F3N9O2/c1-26(12-5-16(29)15(8-30)19(39)6-12)20-21(31)35-22(36-23(20)37-25(26)40)18-9-38-24(32-10-33-38)17(34-18)4-11-2-13(27)7-14(28)3-11/h2-3,5-7,9-10,39H,4H2,1H3,(H3,31,35,36,37,40)
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0.280n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463174
PNG
(4-Amino-5-(3-chloro-4- hydroxyphenyl)-2-{8-[(2- fl...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1ccc(O)c(Cl)c1
Show InChI InChI=1S/C26H19ClFN7O2/c1-26(14-6-7-19(36)15(27)11-14)20-21(29)32-22(33-23(20)34-25(26)37)18-12-35-9-8-30-24(35)17(31-18)10-13-4-2-3-5-16(13)28/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37)
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0.283n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463175
PNG
(4-Amino-5-(3-fluoro-4- hydroxyphenyl)-2-{8-[(4- fl...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2)n1)c1ccc(O)c(F)c1
Show InChI InChI=1S/C26H19F2N7O2/c1-26(14-4-7-19(36)16(28)11-14)20-21(29)32-22(33-23(20)34-25(26)37)18-12-35-9-8-30-24(35)17(31-18)10-13-2-5-15(27)6-3-13/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37)
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0.291n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463176
PNG
(4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-{8-[(4- fl...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C26H19ClFN7O2/c1-26(14-4-7-16(27)19(36)11-14)20-21(29)32-22(33-23(20)34-25(26)37)18-12-35-9-8-30-24(35)17(31-18)10-13-2-5-15(28)6-3-13/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37)
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0.292n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463178
PNG
(4-Amino-5-(4-chloro-3-fluoro-5- hydroxyphenyl)-2-(...)
Show SMILES CC(C)CCc1nc(cn2ccnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1cc(O)c(Cl)c(F)c1
Show InChI InChI=1S/C24H23ClFN7O2/c1-11(2)4-5-14-22-28-6-7-33(22)10-15(29-14)20-30-19(27)17-21(31-20)32-23(35)24(17,3)12-8-13(26)18(25)16(34)9-12/h6-11,34H,4-5H2,1-3H3,(H3,27,30,31,32,35)
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0.306n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463179
PNG
(4-Amino-5-(3-hydroxy-4- (trifluoromethyl)phenyl)-5...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2F)n1)c1ccc(c(O)c1)C(F)(F)F
Show InChI InChI=1S/C27H17F6N7O2/c1-26(12-2-3-14(18(41)8-12)27(31,32)33)19-21(34)37-22(38-23(19)39-25(26)42)17-10-40-5-4-35-24(40)16(36-17)7-11-6-13(28)9-15(29)20(11)30/h2-6,8-10,41H,7H2,1H3,(H3,34,37,38,39,42)
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0.312n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463180
PNG
(4-Amino-2-{8-[(2,4- difluorophenyl)methyl]imidazo[...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2F)n1)c1cccc(O)c1
Show InChI InChI=1S/C26H19F2N7O2/c1-26(14-3-2-4-16(36)10-14)20-21(29)32-22(33-23(20)34-25(26)37)19-12-35-8-7-30-24(35)18(31-19)9-13-5-6-15(27)11-17(13)28/h2-8,10-12,36H,9H2,1H3,(H3,29,32,33,34,37)
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0.317n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463181
PNG
(4-Amino-5-(3-chloro-4- hydroxyphenyl)-2-{8-[(3- fl...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1)c1ccc(O)c(Cl)c1
Show InChI InChI=1S/C26H19ClFN7O2/c1-26(14-5-6-19(36)16(27)11-14)20-21(29)32-22(33-23(20)34-25(26)37)18-12-35-8-7-30-24(35)17(31-18)10-13-3-2-4-15(28)9-13/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37)
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0.333n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463295
PNG
(4-(4-amino-2-{8-(3- fluorobenzyl)imidazo- [1,2-a]p...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1)c1cc(O)c(C#N)c(Cl)c1
Show InChI InChI=1S/C27H18ClFN8O2/c1-27(14-9-17(28)16(11-30)20(38)10-14)21-22(31)34-23(35-24(21)36-26(27)39)19-12-37-6-5-32-25(37)18(33-19)8-13-3-2-4-15(29)7-13/h2-7,9-10,12,38H,8H2,1H3,(H3,31,34,35,36,39)
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0.333n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463279
PNG
(5-(4-Chloro-3-hydroxy- phenyl)-2-{8-[(3-fluoro- ph...)
Show SMILES CC1(C(=O)Nc2nc(nc(NCC(O)C(F)(F)F)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C29H22ClF4N7O3/c1-28(15-5-6-17(30)20(42)11-15)22-24(36-12-21(43)29(32,33)34)38-23(39-25(22)40-27(28)44)19-13-41-8-7-35-26(41)18(37-19)10-14-3-2-4-16(31)9-14/h2-9,11,13,21,42-43H,10,12H2,1H3,(H2,36,38,39,40,44)
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0.347n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463271
PNG
(4-Amino-2-(8-benzyl- imidaxol[1,2-a]pyrazin- 6-yl)...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2)n1)c1cccc(O)c1
Show InChI InChI=1S/C26H21N7O2/c1-26(16-8-5-9-17(34)13-16)20-21(27)30-22(31-23(20)32-25(26)35)19-14-33-11-10-28-24(33)18(29-19)12-15-6-3-2-4-7-15/h2-11,13-14,34H,12H2,1H3,(H3,27,30,31,32,35)
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0.372n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463239
PNG
(4-Amino-5-(5-chloro-4- hydroxypyridin-2-yl)-2-(8- ...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCCC2)n1)c1cc(O)c(Cl)cn1
Show InChI InChI=1S/C25H25ClN8O2/c1-25(18-10-17(35)14(26)11-29-18)19-20(27)31-21(32-22(19)33-24(25)36)16-12-34-8-7-28-23(34)15(30-16)9-13-5-3-2-4-6-13/h7-8,10-13H,2-6,9H2,1H3,(H,29,35)(H3,27,31,32,33,36)
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0.374n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463297
PNG
(4-amino-2-(8-{2- fluorobenzyl}imidazo- [1,2-a]pyra...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1cc(O)c(cn1)C(F)(F)F
Show InChI InChI=1S/C26H18F4N8O2/c1-25(18-9-17(39)13(10-33-18)26(28,29)30)19-20(31)35-21(36-22(19)37-24(25)40)16-11-38-7-6-32-23(38)15(34-16)8-12-4-2-3-5-14(12)27/h2-7,9-11H,8H2,1H3,(H,33,39)(H3,31,35,36,37,40)
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0.378n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463269
PNG
(4-Amino-2-{8-[(3-fluorophenyl)methyl]imidazo[1,2-a...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1)c1cccc(O)c1
Show InChI InChI=1S/C26H20FN7O2/c1-26(15-5-3-7-17(35)12-15)20-21(28)31-22(32-23(20)33-25(26)36)19-13-34-9-8-29-24(34)18(30-19)11-14-4-2-6-16(27)10-14/h2-10,12-13,35H,11H2,1H3,(H3,28,31,32,33,36)
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0.382n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463182
PNG
(4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-{8-[(3,5- ...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C26H18ClF2N7O2/c1-26(13-2-3-16(27)19(37)9-13)20-21(30)33-22(34-23(20)35-25(26)38)18-11-36-5-4-31-24(36)17(32-18)8-12-6-14(28)10-15(29)7-12/h2-7,9-11,37H,8H2,1H3,(H3,30,33,34,35,38)
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0.393n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463228
PNG
(4-Amino-2-(8- (cyclohexylmethyl)imidazo[1,2- a]pyr...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCCC2)n1)c1cccc(O)c1
Show InChI InChI=1S/C26H27N7O2/c1-26(16-8-5-9-17(34)13-16)20-21(27)30-22(31-23(20)32-25(26)35)19-14-33-11-10-28-24(33)18(29-19)12-15-6-3-2-4-7-15/h5,8-11,13-15,34H,2-4,6-7,12H2,1H3,(H3,27,30,31,32,35)
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0.402n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463184
PNG
(4-(4-Amino-2-{8-[(3,5- difluorophenyl)methyl]imida...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2)n1)c1cc(O)c(C#N)c(F)c1
Show InChI InChI=1S/C27H17F3N8O2/c1-27(13-7-17(30)16(10-31)20(39)8-13)21-22(32)35-23(36-24(21)37-26(27)40)19-11-38-3-2-33-25(38)18(34-19)6-12-4-14(28)9-15(29)5-12/h2-5,7-9,11,39H,6H2,1H3,(H3,32,35,36,37,40)
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0.410n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463296
PNG
(4-amino-2-(8-{3- fluorobenzyl}imidazo- [1,2-a]pyra...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1)c1cc(O)c(cn1)C(F)(F)F
Show InChI InChI=1S/C26H18F4N8O2/c1-25(18-9-17(39)14(10-33-18)26(28,29)30)19-20(31)35-21(36-22(19)37-24(25)40)16-11-38-6-5-32-23(38)15(34-16)8-12-3-2-4-13(27)7-12/h2-7,9-11H,8H2,1H3,(H,33,39)(H3,31,35,36,37,40)
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0.416n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463183
PNG
(4-Amino-5-(4-fluoro-3- hydroxyphenyl)-2-{8-[(4- fl...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2)n1)c1ccc(F)c(O)c1
Show InChI InChI=1S/C26H19F2N7O2/c1-26(14-4-7-16(28)19(36)11-14)20-21(29)32-22(33-23(20)34-25(26)37)18-12-35-9-8-30-24(35)17(31-18)10-13-2-5-15(27)6-3-13/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37)
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0.427n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463185
PNG
(4-Amino-2-(8-butylimidazo[1,2- a]pyrazin-6-yl)-5-(...)
Show SMILES CCCCc1nc(cn2ccnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1cc(O)c(Cl)c(F)c1
Show InChI InChI=1S/C23H21ClFN7O2/c1-3-4-5-13-21-27-6-7-32(21)10-14(28-13)19-29-18(26)16-20(30-19)31-22(34)23(16,2)11-8-12(25)17(24)15(33)9-11/h6-10,33H,3-5H2,1-2H3,(H3,26,29,30,31,34)
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0.446n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463189
PNG
(4-Amino-2-{8-[(4- fluorophenyl)methyl]imidazo[1,2-...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2)n1)c1ccc(O)cc1
Show InChI InChI=1S/C26H20FN7O2/c1-26(15-4-8-17(35)9-5-15)20-21(28)31-22(32-23(20)33-25(26)36)19-13-34-11-10-29-24(34)18(30-19)12-14-2-6-16(27)7-3-14/h2-11,13,35H,12H2,1H3,(H3,28,31,32,33,36)
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0.457n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463186
PNG
(4-Amino-5-(5-chloro-4- hydroxypyridin-2-yl)-2-{8-[...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2)n1)c1cc(O)c(Cl)cn1
Show InChI InChI=1S/C25H17ClF2N8O2/c1-25(18-8-17(37)14(26)9-31-18)19-20(29)33-21(34-22(19)35-24(25)38)16-10-36-3-2-30-23(36)15(32-16)6-11-4-12(27)7-13(28)5-11/h2-5,7-10H,6H2,1H3,(H,31,37)(H3,29,33,34,35,38)
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0.479n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463187
PNG
(4-Amino-5-(3-fluoro-4- hydroxyphenyl)-2-{8-[(4- fl...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(Cc2ccc(F)cc2)n1)c1ccc(O)c(F)c1
Show InChI InChI=1S/C25H18F2N8O2/c1-25(13-4-7-18(36)15(27)9-13)19-20(28)32-21(33-22(19)34-24(25)37)17-10-35-23(29-11-30-35)16(31-17)8-12-2-5-14(26)6-3-12/h2-7,9-11,36H,8H2,1H3,(H3,28,32,33,34,37)
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0.490n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463188
PNG
(4-Amino-2-(8-butyl- [1,2,4]triazolo[1,5-a]pyrazin-...)
Show SMILES CCCCc1nc(cn2ncnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1cc(O)c(Cl)c(F)c1
Show InChI InChI=1S/C22H20ClFN8O2/c1-3-4-5-12-20-26-9-27-32(20)8-13(28-12)18-29-17(25)15-19(30-18)31-21(34)22(15,2)10-6-11(24)16(23)14(33)7-10/h6-9,33H,3-5H2,1-2H3,(H3,25,29,30,31,34)
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0.496n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463190
PNG
(4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-{8-[(4- ch...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccc(Cl)cc2)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C26H19Cl2N7O2/c1-26(14-4-7-16(28)19(36)11-14)20-21(29)32-22(33-23(20)34-25(26)37)18-12-35-9-8-30-24(35)17(31-18)10-13-2-5-15(27)6-3-13/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37)
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0.507n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463273
PNG
(4-Amino-5-(3-fluoro-4- hydroxyphenyl)-2-{8-[(3- fl...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1)c1ccc(O)c(F)c1
Show InChI InChI=1S/C26H19F2N7O2/c1-26(14-5-6-19(36)16(28)11-14)20-21(29)32-22(33-23(20)34-25(26)37)18-12-35-8-7-30-24(35)17(31-18)10-13-3-2-4-15(27)9-13/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37)
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0.508n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463300
PNG
(4-(4-amino-2-{8-(2- fluorobenzyl)-[1,2,4]- triazol...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(Cc2ccccc2F)n1)c1cc(O)c(C#N)c(Cl)c1
Show InChI InChI=1S/C26H17ClFN9O2/c1-26(13-7-15(27)14(9-29)19(38)8-13)20-21(30)34-22(35-23(20)36-25(26)39)18-10-37-24(31-11-32-37)17(33-18)6-12-4-2-3-5-16(12)28/h2-5,7-8,10-11,38H,6H2,1H3,(H3,30,34,35,36,39)
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0.509n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463255
PNG
(4-Amino-5-(4-chloro-3-hydroxyphenyl)-5-methyl-2-{8...)
Show SMILES CC1CCC(Cc2nc(cn3ccnc23)-c2nc3NC(=O)C(C)(c3c(N)n2)c2ccc(Cl)c(O)c2)CC1
Show InChI InChI=1S/C27H28ClN7O2/c1-14-3-5-15(6-4-14)11-18-25-30-9-10-35(25)13-19(31-18)23-32-22(29)21-24(33-23)34-26(37)27(21,2)16-7-8-17(28)20(36)12-16/h7-10,12-15,36H,3-6,11H2,1-2H3,(H3,29,32,33,34,37)
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0.524n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463246
PNG
(4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-{8-[(2- fl...)
Show SMILES Cc1cn2cc(nc(Cc3ccccc3F)c2n1)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C27H21ClFN7O2/c1-13-11-36-12-19(32-18(25(36)31-13)9-14-5-3-4-6-17(14)29)23-33-22(30)21-24(34-23)35-26(38)27(21,2)15-7-8-16(28)20(37)10-15/h3-8,10-12,37H,9H2,1-2H3,(H3,30,33,34,35,38)
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0.544n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463191
PNG
(4-Amino-2-{8-[(3- fluorophenyl)methyl]imidazo[1,2-...)
Show SMILES Cc1cc(ccc1O)C1(C)C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1
Show InChI InChI=1S/C27H22FN7O2/c1-14-10-16(6-7-20(14)36)27(2)21-22(29)32-23(33-24(21)34-26(27)37)19-13-35-9-8-30-25(35)18(31-19)12-15-4-3-5-17(28)11-15/h3-11,13,36H,12H2,1-2H3,(H3,29,32,33,34,37)
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0.565n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463243
PNG
(4-Amino-2-(8- (cyclohexylmethyl)imidazo[1,2- a]pyr...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCCC2)n1)c1cc(O)c(c(F)c1)C(F)(F)F
Show InChI InChI=1S/C27H25F4N7O2/c1-26(14-10-15(28)19(18(39)11-14)27(29,30)31)20-21(32)35-22(36-23(20)37-25(26)40)17-12-38-8-7-33-24(38)16(34-17)9-13-5-3-2-4-6-13/h7-8,10-13,39H,2-6,9H2,1H3,(H3,32,35,36,37,40)
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0.587n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463285
PNG
(5-(4-Chloro-3-hydroxy- phenyl)-2-{8-[(4-fluoro- ph...)
Show SMILES CN1CCN(CC1)c1nc(nc2NC(=O)C(C)(c12)c1ccc(Cl)c(O)c1)-c1cn2ccnc2c(Cc2ccc(F)cc2)n1
Show InChI InChI=1S/C31H28ClFN8O2/c1-31(19-5-8-21(32)24(42)16-19)25-27(38-30(31)43)36-26(37-29(25)40-13-11-39(2)12-14-40)23-17-41-10-9-34-28(41)22(35-23)15-18-3-6-20(33)7-4-18/h3-10,16-17,42H,11-15H2,1-2H3,(H,36,37,38,43)
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0.592n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463256
PNG
(4-Amino-2-(8-(cyclo- hexylmethyl)-[1,2,4]- triazol...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CC2CCCCC2)n1)c1cc(O)ccn1
Show InChI InChI=1S/C24H25N9O2/c1-24(17-10-14(34)7-8-26-17)18-19(25)30-20(31-21(18)32-23(24)35)16-11-33-22(27-12-28-33)15(29-16)9-13-5-3-2-4-6-13/h7-8,10-13H,2-6,9H2,1H3,(H,26,34)(H3,25,30,31,32,35)
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0.634n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463276
PNG
(4-Amino-2-(8-benzyl- imidazo[1,2-a]pyrazin- 6-yl)-...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2)n1)c1ccc(O)c(F)c1
Show InChI InChI=1S/C26H20FN7O2/c1-26(15-7-8-19(35)16(27)12-15)20-21(28)31-22(32-23(20)33-25(26)36)18-13-34-10-9-29-24(34)17(30-18)11-14-5-3-2-4-6-14/h2-10,12-13,35H,11H2,1H3,(H3,28,31,32,33,36)
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0.646n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463193
PNG
(4-Amino-5-(4-fluoro-3- hydroxyphenyl)-2-(8- isopen...)
Show SMILES CC(C)CCc1nc(cn2ccnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(F)c(O)c1
Show InChI InChI=1S/C24H24FN7O2/c1-12(2)4-7-15-22-27-8-9-32(22)11-16(28-15)20-29-19(26)18-21(30-20)31-23(34)24(18,3)13-5-6-14(25)17(33)10-13/h5-6,8-12,33H,4,7H2,1-3H3,(H3,26,29,30,31,34)
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0.676n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463192
PNG
(4-Amino-2-{8-[(3,5- difluorophenyl)methyl]imidazo[...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2)n1)c1ccc(c(O)c1)C(F)(F)F
Show InChI InChI=1S/C27H18F5N7O2/c1-26(13-2-3-16(19(40)9-13)27(30,31)32)20-21(33)36-22(37-23(20)38-25(26)41)18-11-39-5-4-34-24(39)17(35-18)8-12-6-14(28)10-15(29)7-12/h2-7,9-11,40H,8H2,1H3,(H3,33,36,37,38,41)
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0.691n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463292
PNG
(4-amino-5-(5-chloro-4- hydroxypyridin-2-yl)-2- (8-...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCC2)n1)c1cc(O)c(Cl)cn1
Show InChI InChI=1S/C24H23ClN8O2/c1-24(17-9-16(34)13(25)10-28-17)18-19(26)30-20(31-21(18)32-23(24)35)15-11-33-7-6-27-22(33)14(29-15)8-12-4-2-3-5-12/h6-7,9-12H,2-5,8H2,1H3,(H,28,34)(H3,26,30,31,32,35)
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0.706n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463194
PNG
(4-Amino-2-{8-[(3,5- difluorophenyl)methyl]imidazo[...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2)n1)c1cccc(O)c1
Show InChI InChI=1S/C26H19F2N7O2/c1-26(14-3-2-4-17(36)10-14)20-21(29)32-22(33-23(20)34-25(26)37)19-12-35-6-5-30-24(35)18(31-19)9-13-7-15(27)11-16(28)8-13/h2-8,10-12,36H,9H2,1H3,(H3,29,32,33,34,37)
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0.723n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463238
PNG
(4-Amino-5-(5-chloro-4- hydroxypyridin-2-yl)-2-{8-[...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2)n1)c1cc(O)c(Cl)cn1
Show InChI InChI=1S/C25H18ClFN8O2/c1-25(18-9-17(36)14(26)10-30-18)19-20(28)32-21(33-22(19)34-24(25)37)16-11-35-7-6-29-23(35)15(31-16)8-12-2-4-13(27)5-3-12/h2-7,9-11H,8H2,1H3,(H,30,36)(H3,28,32,33,34,37)
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0.729n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463195
PNG
(4-Amino-5-(5-chloro-6- hydroxypyridin-2-yl)-2-(8- ...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCCC2)n1)c1ccc(Cl)c(O)n1
Show InChI InChI=1S/C25H25ClN8O2/c1-25(17-8-7-14(26)23(35)30-17)18-19(27)31-20(32-21(18)33-24(25)36)16-12-34-10-9-28-22(34)15(29-16)11-13-5-3-2-4-6-13/h7-10,12-13H,2-6,11H2,1H3,(H,30,35)(H3,27,31,32,33,36)
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0.746n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463196
PNG
(4-Amino-2-(8-butyl- [1,2,4]triazolo[1,5-a]pyrazin-...)
Show SMILES CCCCc1nc(cn2ncnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C22H21ClN8O2/c1-3-4-5-13-20-25-10-26-31(20)9-14(27-13)18-28-17(24)16-19(29-18)30-21(33)22(16,2)11-6-7-12(23)15(32)8-11/h6-10,32H,3-5H2,1-2H3,(H3,24,28,29,30,33)
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0.775n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463245
PNG
(4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-{8-[(3- fl...)
Show SMILES Cc1cn2cc(nc(Cc3cccc(F)c3)c2n1)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C27H21ClFN7O2/c1-13-11-36-12-19(32-18(25(36)31-13)9-14-4-3-5-16(29)8-14)23-33-22(30)21-24(34-23)35-26(38)27(21,2)15-6-7-17(28)20(37)10-15/h3-8,10-12,37H,9H2,1-2H3,(H3,30,33,34,35,38)
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0.803n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463235
PNG
(4-Amino-5-(3-chloro-4- hydroxyphenyl)-2-(8- (cyclo...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCCC2)n1)c1ccc(O)c(Cl)c1
Show InChI InChI=1S/C26H26ClN7O2/c1-26(15-7-8-19(35)16(27)12-15)20-21(28)31-22(32-23(20)33-25(26)36)18-13-34-10-9-29-24(34)17(30-18)11-14-5-3-2-4-6-14/h7-10,12-14,35H,2-6,11H2,1H3,(H3,28,31,32,33,36)
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0.823n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463291
PNG
(4-Amino-2-(3-amino-8-[(3-fluorophenyl)methyl]imida...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2c(N)cnc2c(Cc2cccc(F)c2)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C26H20ClFN8O2/c1-26(13-5-6-15(27)18(37)9-13)20-21(30)33-22(34-23(20)35-25(26)38)17-11-36-19(29)10-31-24(36)16(32-17)8-12-3-2-4-14(28)7-12/h2-7,9-11,37H,8,29H2,1H3,(H3,30,33,34,35,38)
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0.827n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463242
PNG
(4-Amino-5-(3-chloro-4-fluoro-2- hydroxyphenyl)-2-{...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2)n1)c1ccc(F)c(Cl)c1O
Show InChI InChI=1S/C26H17ClF3N7O2/c1-26(14-2-3-15(30)19(27)20(14)38)18-21(31)34-22(35-23(18)36-25(26)39)17-10-37-5-4-32-24(37)16(33-17)8-11-6-12(28)9-13(29)7-11/h2-7,9-10,38H,8H2,1H3,(H3,31,34,35,36,39)
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0.862n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463198
PNG
(4-Amino-2-(8-butylimidazo[1,2- a]pyrazin-6-yl)-5-(...)
Show SMILES CCCCc1nc(cn2ccnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C23H22ClN7O2/c1-3-4-5-14-21-26-8-9-31(21)11-15(27-14)19-28-18(25)17-20(29-19)30-22(33)23(17,2)12-6-7-13(24)16(32)10-12/h6-11,32H,3-5H2,1-2H3,(H3,25,28,29,30,33)
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0.864n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463197
PNG
(4-Amino-5-(5-chloro-4- hydroxypyridin-2-yl)-2-{8-[...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1)c1cc(O)c(Cl)cn1
Show InChI InChI=1S/C25H18ClFN8O2/c1-25(18-9-17(36)14(26)10-30-18)19-20(28)32-21(33-22(19)34-24(25)37)16-11-35-6-5-29-23(35)15(31-16)8-12-3-2-4-13(27)7-12/h2-7,9-11H,8H2,1H3,(H,30,36)(H3,28,32,33,34,37)
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0.874n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463279
PNG
(5-(4-Chloro-3-hydroxy- phenyl)-2-{8-[(3-fluoro- ph...)
Show SMILES CC1(C(=O)Nc2nc(nc(NCC(O)C(F)(F)F)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C29H22ClF4N7O3/c1-28(15-5-6-17(30)20(42)11-15)22-24(36-12-21(43)29(32,33)34)38-23(39-25(22)40-27(28)44)19-13-41-8-7-35-26(41)18(37-19)10-14-3-2-4-16(31)9-14/h2-9,11,13,21,42-43H,10,12H2,1H3,(H2,36,38,39,40,44)
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0.884n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463298
PNG
(4-amino-2-{8- (cyclohexylmethyl)- imidazo[1,2-a]py...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCCC2)n1)c1cc(O)c(cn1)C(F)(F)F
Show InChI InChI=1S/C26H25F3N8O2/c1-25(18-10-17(38)14(11-32-18)26(27,28)29)19-20(30)34-21(35-22(19)36-24(25)39)16-12-37-8-7-31-23(37)15(33-16)9-13-5-3-2-4-6-13/h7-8,10-13H,2-6,9H2,1H3,(H,32,38)(H3,30,34,35,36,39)
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0.905n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463254
PNG
(4-Amino-5-(4-chloro-3- hydroxyphenyl)-5-methyl- 2-...)
Show SMILES CC1CCC(Cc2nc(cn3ccnc23)-c2nc3NC(=O)C(C)(c3c(N)n2)c2ccc(Cl)c(O)c2)CC1
Show InChI InChI=1S/C27H28ClN7O2/c1-14-3-5-15(6-4-14)11-18-25-30-9-10-35(25)13-19(31-18)23-32-22(29)21-24(33-23)34-26(37)27(21,2)16-7-8-17(28)20(36)12-16/h7-10,12-15,36H,3-6,11H2,1-2H3,(H3,29,32,33,34,37)
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0.924n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463301
PNG
(4-(4-amino-2-{8- (cyclohexylmethyl)- [1,2,4]triazo...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CC2CCCCC2)n1)c1cc(O)c(C#N)c(Cl)c1
Show InChI InChI=1S/C26H24ClN9O2/c1-26(14-8-16(27)15(10-28)19(37)9-14)20-21(29)33-22(34-23(20)35-25(26)38)18-11-36-24(30-12-31-36)17(32-18)7-13-5-3-2-4-6-13/h8-9,11-13,37H,2-7H2,1H3,(H3,29,33,34,35,38)
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0.989n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463200
PNG
(4-Amino-5-(3-fluoro-4- hydroxyphenyl)-2-(8- isopen...)
Show SMILES CC(C)CCc1nc(cn2ccnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(O)c(F)c1
Show InChI InChI=1S/C24H24FN7O2/c1-12(2)4-6-15-22-27-8-9-32(22)11-16(28-15)20-29-19(26)18-21(30-20)31-23(34)24(18,3)13-5-7-17(33)14(25)10-13/h5,7-12,33H,4,6H2,1-3H3,(H3,26,29,30,31,34)
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1.08n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463199
PNG
(4-Amino-5-(4-chloro-5- hydroxypyridin-2-yl)-2-{8-[...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1cc(Cl)c(O)cn1
Show InChI InChI=1S/C25H18ClFN8O2/c1-25(18-9-13(26)17(36)10-30-18)19-20(28)32-21(33-22(19)34-24(25)37)16-11-35-7-6-29-23(35)15(31-16)8-12-4-2-3-5-14(12)27/h2-7,9-11,36H,8H2,1H3,(H3,28,32,33,34,37)
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1.08n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463294
PNG
(4-(4-amino-2-{8-(2- fluorobenzyl)imidazo- [1,2-a]p...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1cc(O)c(C#N)c(Cl)c1
Show InChI InChI=1S/C27H18ClFN8O2/c1-27(14-9-16(28)15(11-30)20(38)10-14)21-22(31)34-23(35-24(21)36-26(27)39)19-12-37-7-6-32-25(37)18(33-19)8-13-4-2-3-5-17(13)29/h2-7,9-10,12,38H,8H2,1H3,(H3,31,34,35,36,39)
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1.09n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463274
PNG
(4-Amino-2-{8-[(3- chlorophenyl)methyl]- imidazo[1,...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(Cl)c2)n1)c1ccc(O)c(F)c1
Show InChI InChI=1S/C26H19ClFN7O2/c1-26(14-5-6-19(36)16(28)11-14)20-21(29)32-22(33-23(20)34-25(26)37)18-12-35-8-7-30-24(35)17(31-18)10-13-3-2-4-15(27)9-13/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37)
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1.10n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463199
PNG
(4-Amino-5-(4-chloro-5- hydroxypyridin-2-yl)-2-{8-[...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1cc(Cl)c(O)cn1
Show InChI InChI=1S/C25H18ClFN8O2/c1-25(18-9-13(26)17(36)10-30-18)19-20(28)32-21(33-22(19)34-24(25)37)16-11-35-7-6-29-23(35)15(31-16)8-12-4-2-3-5-14(12)27/h2-7,9-11,36H,8H2,1H3,(H3,28,32,33,34,37)
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1.10n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463293
PNG
(4-(4-amino-2-{8- (cyclohexylmethyl)- imidazo[1,2-a...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCCC2)n1)c1cc(O)c(C#N)c(Cl)c1
Show InChI InChI=1S/C27H25ClN8O2/c1-27(15-10-17(28)16(12-29)20(37)11-15)21-22(30)33-23(34-24(21)35-26(27)38)19-13-36-8-7-31-25(36)18(32-19)9-14-5-3-2-4-6-14/h7-8,10-11,13-14,37H,2-6,9H2,1H3,(H3,30,33,34,35,38)
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1.14n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463201
PNG
(4-Amino-5-(4-chloro-3- hydroxyphenyl)-5-methyl-2-(...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CCCC(F)(F)F)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C23H19ClF3N7O2/c1-22(11-4-5-12(24)15(35)9-11)16-17(28)31-18(32-19(16)33-21(22)36)14-10-34-8-7-29-20(34)13(30-14)3-2-6-23(25,26)27/h4-5,7-10,35H,2-3,6H2,1H3,(H3,28,31,32,33,36)
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1.21n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463281
PNG
(5-(4-Chloro-3-hydroxy- phenyl)-2-{8-[(4-fluoro- ph...)
Show SMILES CC1(C(=O)Nc2nc(nc(NCC(O)C(F)(F)F)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C29H22ClF4N7O3/c1-28(15-4-7-17(30)20(42)11-15)22-24(36-12-21(43)29(32,33)34)38-23(39-25(22)40-27(28)44)19-13-41-9-8-35-26(41)18(37-19)10-14-2-5-16(31)6-3-14/h2-9,11,13,21,42-43H,10,12H2,1H3,(H2,36,38,39,40,44)
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1.21n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463203
PNG
(4-Amino-5-(5-chloro-4- hydroxypyridin-2-yl)-2-(8- ...)
Show SMILES CC(C)CCc1nc(cn2ccnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1cc(O)c(Cl)cn1
Show InChI InChI=1S/C23H23ClN8O2/c1-11(2)4-5-13-21-26-6-7-32(21)10-14(28-13)19-29-18(25)17-20(30-19)31-22(34)23(17,3)16-8-15(33)12(24)9-27-16/h6-11H,4-5H2,1-3H3,(H,27,33)(H3,25,29,30,31,34)
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1.24n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463202
PNG
(4-Amino-2-{8-[(4- chlorophenyl)methyl]imidazo[1,2-...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccc(Cl)cc2)n1)c1cccc(O)c1
Show InChI InChI=1S/C26H20ClN7O2/c1-26(15-3-2-4-17(35)12-15)20-21(28)31-22(32-23(20)33-25(26)36)19-13-34-10-9-29-24(34)18(30-19)11-14-5-7-16(27)8-6-14/h2-10,12-13,35H,11H2,1H3,(H3,28,31,32,33,36)
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1.24n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463281
PNG
(5-(4-Chloro-3-hydroxy- phenyl)-2-{8-[(4-fluoro- ph...)
Show SMILES CC1(C(=O)Nc2nc(nc(NCC(O)C(F)(F)F)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C29H22ClF4N7O3/c1-28(15-4-7-17(30)20(42)11-15)22-24(36-12-21(43)29(32,33)34)38-23(39-25(22)40-27(28)44)19-13-41-9-8-35-26(41)18(37-19)10-14-2-5-16(31)6-3-14/h2-9,11,13,21,42-43H,10,12H2,1H3,(H2,36,38,39,40,44)
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1.46n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463204
PNG
(4-Amino-5-(4-hydroxyphenyl)-2- (8-isopentylimidazo...)
Show SMILES CC(C)CCc1nc(cn2ccnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(O)cc1
Show InChI InChI=1S/C24H25N7O2/c1-13(2)4-9-16-22-26-10-11-31(22)12-17(27-16)20-28-19(25)18-21(29-20)30-23(33)24(18,3)14-5-7-15(32)8-6-14/h5-8,10-13,32H,4,9H2,1-3H3,(H3,25,28,29,30,33)
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1.54n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463287
PNG
(5-(4-Chloro-3-hydroxy- phenyl)-4-(4,4-difluoro- pi...)
Show SMILES CC1(C(=O)Nc2nc(nc(N3CCC(F)(F)CC3)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C31H25ClF3N7O2/c1-30(18-4-7-20(32)23(43)15-18)24-26(40-29(30)44)38-25(39-28(24)41-11-8-31(34,35)9-12-41)22-16-42-13-10-36-27(42)21(37-22)14-17-2-5-19(33)6-3-17/h2-7,10,13,15-16,43H,8-9,11-12,14H2,1H3,(H,38,39,40,44)
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1.57n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463257
PNG
(4-Amino-2-{8-[(3- fluorophenyl)methyl]- [1,2,4]tri...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(Cc2cccc(F)c2)n1)c1cc(O)ccn1
Show InChI InChI=1S/C24H18FN9O2/c1-24(17-9-14(35)5-6-27-17)18-19(26)31-20(32-21(18)33-23(24)36)16-10-34-22(28-11-29-34)15(30-16)8-12-3-2-4-13(25)7-12/h2-7,9-11H,8H2,1H3,(H,27,35)(H3,26,31,32,33,36)
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1.62n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463205
PNG
(4-Amino-5-(3-hydroxyphenyl)-2- (8-isopentylimidazo...)
Show SMILES CC(C)CCc1nc(cn2ccnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1cccc(O)c1
Show InChI InChI=1S/C24H25N7O2/c1-13(2)7-8-16-22-26-9-10-31(22)12-17(27-16)20-28-19(25)18-21(29-20)30-23(33)24(18,3)14-5-4-6-15(32)11-14/h4-6,9-13,32H,7-8H2,1-3H3,(H3,25,28,29,30,33)
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1.72n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463258
PNG
(4-Amino-5-(3-chloro-4- hydroxypyridin-2-yl)-2- {8-...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2)n1)c1nccc(O)c1Cl
Show InChI InChI=1S/C25H17ClF2N8O2/c1-25(19-18(26)16(37)2-3-30-19)17-20(29)33-21(34-22(17)35-24(25)38)15-10-36-5-4-31-23(36)14(32-15)8-11-6-12(27)9-13(28)7-11/h2-7,9-10H,8H2,1H3,(H,30,37)(H3,29,33,34,35,38)
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1.74n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463259
PNG
(4-Amino-2-(8-(cyclo- hexylmethyl)-[1,2,4]- triazol...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CC2CCCCC2)n1)c1cc(Cl)c(O)c(Cl)c1
Show InChI InChI=1S/C25H24Cl2N8O2/c1-25(13-8-14(26)19(36)15(27)9-13)18-20(28)32-21(33-22(18)34-24(25)37)17-10-35-23(29-11-30-35)16(31-17)7-12-5-3-2-4-6-12/h8-12,36H,2-7H2,1H3,(H3,28,32,33,34,37)
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1.78n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463252
PNG
(4-Amino-5-(4-chloro-3-hydroxyphenyl)-2-(8-(4-fluor...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CCCCF)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C22H20ClFN8O2/c1-22(11-5-6-12(23)15(33)8-11)16-17(25)29-18(30-19(16)31-21(22)34)14-9-32-20(26-10-27-32)13(28-14)4-2-3-7-24/h5-6,8-10,33H,2-4,7H2,1H3,(H3,25,29,30,31,34)
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1.84n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463206
PNG
(4-Amino-5-(3-chloro-4- hydroxyphenyl)-2-{8-[(4- fl...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2)n1)c1ccc(O)c(Cl)c1
Show InChI InChI=1S/C26H19ClFN7O2/c1-26(14-4-7-19(36)16(27)11-14)20-21(29)32-22(33-23(20)34-25(26)37)18-12-35-9-8-30-24(35)17(31-18)10-13-2-5-15(28)6-3-13/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37)
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1.92n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463277
PNG
(5-(4-Fluoro-3-hydroxyphenyl)-4-(3-hydroxy-3-(trifl...)
Show SMILES CC1(C(=O)Nc2nc(nc(N3CC(O)(C3)C(F)(F)F)c12)-c1cn2ccnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(F)c(O)c1
Show InChI InChI=1S/C27H20F9N7O3/c1-23(12-2-3-13(28)16(44)8-12)17-19(41-22(23)45)39-18(40-21(17)43-10-24(46,11-43)26(31,32)33)15-9-42-7-6-37-20(42)14(38-15)4-5-25(29,30)27(34,35)36/h2-3,6-9,44,46H,4-5,10-11H2,1H3,(H,39,40,41,45)
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2n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463207
PNG
(4-Amino-2-(8-butyl- [1,2,4]triazolo[1,5-a]pyrazin-...)
Show SMILES CCCCc1nc(cn2ncnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(c(O)c1)C(F)(F)F
Show InChI InChI=1S/C23H21F3N8O2/c1-3-4-5-13-20-28-10-29-34(20)9-14(30-13)18-31-17(27)16-19(32-18)33-21(36)22(16,2)11-6-7-12(15(35)8-11)23(24,25)26/h6-10,35H,3-5H2,1-2H3,(H3,27,31,32,33,36)
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2.08n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463209
PNG
(4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-(8-(2- cyc...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CCC2CCCCC2)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C27H28ClN7O2/c1-27(16-8-9-17(28)20(36)13-16)21-22(29)32-23(33-24(21)34-26(27)37)19-14-35-12-11-30-25(35)18(31-19)10-7-15-5-3-2-4-6-15/h8-9,11-15,36H,2-7,10H2,1H3,(H3,29,32,33,34,37)
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2.20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463208
PNG
(4-Amino-2-(8-butyl- [1,2,4]triazolo[1,5-a]pyrazin-...)
Show SMILES CCCCc1nc(cn2ncnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(F)c(O)c1
Show InChI InChI=1S/C22H21FN8O2/c1-3-4-5-13-20-25-10-26-31(20)9-14(27-13)18-28-17(24)16-19(29-18)30-21(33)22(16,2)11-6-7-12(23)15(32)8-11/h6-10,32H,3-5H2,1-2H3,(H3,24,28,29,30,33)
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2.21n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463210
PNG
(4-Amino-5-(3-hydroxy-4- (trifluoromethyl)phenyl)-2...)
Show SMILES CC(C)CCc1nc(cn2ccnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(c(O)c1)C(F)(F)F
Show InChI InChI=1S/C25H24F3N7O2/c1-12(2)4-7-15-22-30-8-9-35(22)11-16(31-15)20-32-19(29)18-21(33-20)34-23(37)24(18,3)13-5-6-14(17(36)10-13)25(26,27)28/h5-6,8-12,36H,4,7H2,1-3H3,(H3,29,32,33,34,37)
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2.22n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463232
PNG
(4-Amino-2-(8-(2- cyclohexylethyl)imidazo[1,2- a]py...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CCC2CCCCC2)n1)c1ccc(F)c(O)c1
Show InChI InChI=1S/C27H28FN7O2/c1-27(16-8-9-17(28)20(36)13-16)21-22(29)32-23(33-24(21)34-26(27)37)19-14-35-12-11-30-25(35)18(31-19)10-7-15-5-3-2-4-6-15/h8-9,11-15,36H,2-7,10H2,1H3,(H3,29,32,33,34,37)
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2.22n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463211
PNG
(4-Amino-5-(4-chloro-3- hydroxyphenyl)-5-methyl-2-(...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C23H17ClF5N7O2/c1-21(10-2-3-11(24)14(37)8-10)15-16(30)33-17(34-18(15)35-20(21)38)13-9-36-7-6-31-19(36)12(32-13)4-5-22(25,26)23(27,28)29/h2-3,6-9,37H,4-5H2,1H3,(H3,30,33,34,35,38)
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2.26n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463283
PNG
(5-(4-Chloro-3-hydroxy- phenyl)-5-methyl-2-(8- (3,3...)
Show SMILES CC1(C(=O)Nc2nc(nc(NCC(O)C(F)(F)F)c12)-c1cn2ncnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C25H19ClF8N8O3/c1-22(10-2-3-11(26)14(43)6-10)16-18(35-7-15(44)24(29,30)31)39-17(40-19(16)41-21(22)45)13-8-42-20(36-9-37-42)12(38-13)4-5-23(27,28)25(32,33)34/h2-3,6,8-9,15,43-44H,4-5,7H2,1H3,(H2,35,39,40,41,45)
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2.34n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463236
PNG
(4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-{8-[(2,6- ...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2c(F)cccc2F)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C26H18ClF2N7O2/c1-26(12-5-6-14(27)19(37)9-12)20-21(30)33-22(34-23(20)35-25(26)38)18-11-36-8-7-31-24(36)17(32-18)10-13-15(28)3-2-4-16(13)29/h2-9,11,37H,10H2,1H3,(H3,30,33,34,35,38)
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2.43n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463234
PNG
(4-Amino-5-(4-chloro-3- hydroxyphenyl)-5-methyl-2-(...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C22H16ClF5N8O2/c1-20(9-2-3-10(23)13(37)6-9)14-15(29)33-16(34-17(14)35-19(20)38)12-7-36-18(30-8-31-36)11(32-12)4-5-21(24,25)22(26,27)28/h2-3,6-8,37H,4-5H2,1H3,(H3,29,33,34,35,38)
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2.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463212
PNG
(4-Amino-5-(3-chloro-4- hydroxyphenyl)-2-{8-[(4- fl...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(Cc2ccc(F)cc2)n1)c1ccc(O)c(Cl)c1
Show InChI InChI=1S/C25H18ClFN8O2/c1-25(13-4-7-18(36)15(26)9-13)19-20(28)32-21(33-22(19)34-24(25)37)17-10-35-23(29-11-30-35)16(31-17)8-12-2-5-14(27)6-3-12/h2-7,9-11,36H,8H2,1H3,(H3,28,32,33,34,37)
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2.57n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463272
PNG
(4-Amino-2-{8-[(3- chlorophenyl)methyl]- imidazo[1,...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(Cl)c2)n1)c1cccc(O)c1
Show InChI InChI=1S/C26H20ClN7O2/c1-26(15-5-3-7-17(35)12-15)20-21(28)31-22(32-23(20)33-25(26)36)19-13-34-9-8-29-24(34)18(30-19)11-14-4-2-6-16(27)10-14/h2-10,12-13,35H,11H2,1H3,(H3,28,31,32,33,36)
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2.63n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463288
PNG
(5-(4-Chloro-3-hydroxy- phenyl)-5-methyl-2-(8- (3,3...)
Show SMILES CC1(C(=O)Nc2nc(nc(N3CCC(CC3)C(F)(F)F)c12)-c1cn2ncnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C28H23ClF8N8O2/c1-25(14-2-3-15(29)18(46)10-14)19-21(43-24(25)47)41-20(42-23(19)44-8-5-13(6-9-44)27(32,33)34)17-11-45-22(38-12-39-45)16(40-17)4-7-26(30,31)28(35,36)37/h2-3,10-13,46H,4-9H2,1H3,(H,41,42,43,47)
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2.63n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463213
PNG
(4-Amino-2-(8- (cyclohexylmethyl)- [1,2,4]triazolo[...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CC2CCCCC2)n1)c1ccc(Cl)c(O)c1Cl
Show InChI InChI=1S/C25H24Cl2N8O2/c1-25(13-7-8-14(26)19(36)18(13)27)17-20(28)32-21(33-22(17)34-24(25)37)16-10-35-23(29-11-30-35)15(31-16)9-12-5-3-2-4-6-12/h7-8,10-12,36H,2-6,9H2,1H3,(H3,28,32,33,34,37)
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2.65n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463266
PNG
(4-Amino-5-(4- hydroxypyridin-2-yl)- 2-(8-isopentyl...)
Show SMILES CC(C)CCc1nc(cn2ncnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1cc(O)ccn1
Show InChI InChI=1S/C22H23N9O2/c1-11(2)4-5-13-20-25-10-26-31(20)9-14(27-13)18-28-17(23)16-19(29-18)30-21(33)22(16,3)15-8-12(32)6-7-24-15/h6-11H,4-5H2,1-3H3,(H,24,32)(H3,23,28,29,30,33)
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2.76n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463233
PNG
(4-Amino-5-(4-chloro-3- hydroxyphenyl)-5-methyl-2-(...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CCCC(F)(F)F)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C22H18ClF3N8O2/c1-21(10-4-5-11(23)14(35)7-10)15-16(27)31-17(32-18(15)33-20(21)36)13-8-34-19(28-9-29-34)12(30-13)3-2-6-22(24,25)26/h4-5,7-9,35H,2-3,6H2,1H3,(H3,27,31,32,33,36)
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2.80n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463260
PNG
(4-Amino-2-(8-(cyclo- hexylmethyl)imidazo- [1,2-a]p...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCCC2)n1)c1cc(Cl)c(O)c(Cl)c1
Show InChI InChI=1S/C26H25Cl2N7O2/c1-26(14-10-15(27)20(36)16(28)11-14)19-21(29)32-22(33-23(19)34-25(26)37)18-12-35-8-7-30-24(35)17(31-18)9-13-5-3-2-4-6-13/h7-8,10-13,36H,2-6,9H2,1H3,(H3,29,32,33,34,37)
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2.90n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463214
PNG
(4-Amino-2-(8-butyl- [1,2,4]triazolo[1,5-a]pyrazin-...)
Show SMILES CCCCc1nc(cn2ncnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1cccc(O)c1
Show InChI InChI=1S/C22H22N8O2/c1-3-4-8-14-20-24-11-25-30(20)10-15(26-14)18-27-17(23)16-19(28-18)29-21(32)22(16,2)12-6-5-7-13(31)9-12/h5-7,9-11,31H,3-4,8H2,1-2H3,(H3,23,27,28,29,32)
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2.92n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463230
PNG
(4-Amino-2-(8-(2- cyclohexylethyl)imidazo[1,2- a]py...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CCC2CCCCC2)n1)c1ccc(O)c(F)c1
Show InChI InChI=1S/C27H28FN7O2/c1-27(16-8-10-20(36)17(28)13-16)21-22(29)32-23(33-24(21)34-26(27)37)19-14-35-12-11-30-25(35)18(31-19)9-7-15-5-3-2-4-6-15/h8,10-15,36H,2-7,9H2,1H3,(H3,29,32,33,34,37)
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3.46n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463215
PNG
(4-Amino-2-(8- (cyclohexylmethyl)imidazo[1,2- a]pyr...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCCC2)n1)c1ccc(Cl)c(O)c1Cl
Show InChI InChI=1S/C26H25Cl2N7O2/c1-26(14-7-8-15(27)20(36)19(14)28)18-21(29)32-22(33-23(18)34-25(26)37)17-12-35-10-9-30-24(35)16(31-17)11-13-5-3-2-4-6-13/h7-10,12-13,36H,2-6,11H2,1H3,(H3,29,32,33,34,37)
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3.47n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463290
PNG
(5-(4-Chloro-3-hydroxy- phenyl)-5-methyl-2-(8- (3,3...)
Show SMILES CC1(C(=O)Nc2nc(nc(NCCCC(F)(F)F)c12)-c1cn2ncnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C26H21ClF8N8O2/c1-23(12-3-4-13(27)16(44)9-12)17-19(36-8-2-6-25(30,31)32)40-18(41-20(17)42-22(23)45)15-10-43-21(37-11-38-43)14(39-15)5-7-24(28,29)26(33,34)35/h3-4,9-11,44H,2,5-8H2,1H3,(H2,36,40,41,42,45)
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3.54n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463267
PNG
(4-Amino-5-(3-chloro-4- hydroxyphenyl)-5- methyl-2-...)
Show SMILES CC1CCC(Cc2nc(cn3ccnc23)-c2nc3NC(=O)C(C)(c3c(N)n2)c2ccc(O)c(Cl)c2)CC1
Show InChI InChI=1S/C27H28ClN7O2/c1-14-3-5-15(6-4-14)11-18-25-30-9-10-35(25)13-19(31-18)23-32-22(29)21-24(33-23)34-26(37)27(21,2)16-7-8-20(36)17(28)12-16/h7-10,12-15,36H,3-6,11H2,1-2H3,(H3,29,32,33,34,37)
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3.79n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463216
PNG
(4-Amino-2-(8-butyl- [1,2,4]triazolo[1,5-a]pyrazin-...)
Show SMILES CCCCc1nc(cn2ncnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(O)cc1
Show InChI InChI=1S/C22H22N8O2/c1-3-4-5-14-20-24-11-25-30(20)10-15(26-14)18-27-17(23)16-19(28-18)29-21(32)22(16,2)12-6-8-13(31)9-7-12/h6-11,31H,3-5H2,1-2H3,(H3,23,27,28,29,32)
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3.96n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463286
PNG
(4-(4,4-Difluoropiperidin- 1-yl)-2-{8-[(4-fluoro- p...)
Show SMILES CC1(C(=O)Nc2nc(nc(N3CCC(F)(F)CC3)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2)n1)c1cccc(O)c1
Show InChI InChI=1S/C31H26F3N7O2/c1-30(19-3-2-4-21(42)16-19)24-26(39-29(30)43)37-25(38-28(24)40-12-9-31(33,34)10-13-40)23-17-41-14-11-35-27(41)22(36-23)15-18-5-7-20(32)8-6-18/h2-8,11,14,16-17,42H,9-10,12-13,15H2,1H3,(H,37,38,39,43)
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4.01n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463217
PNG
(4-Amino-2-(8-butyl- [1,2,4]triazolo[1,5-a]pyrazin-...)
Show SMILES CCCCc1nc(cn2ncnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(O)c(F)c1
Show InChI InChI=1S/C22H21FN8O2/c1-3-4-5-13-20-25-10-26-31(20)9-14(27-13)18-28-17(24)16-19(29-18)30-21(33)22(16,2)11-6-7-15(32)12(23)8-11/h6-10,32H,3-5H2,1-2H3,(H3,24,28,29,30,33)
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4.08n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463289
PNG
(5-(4-Chloro-3-hydroxy- phenyl)-5-methyl-2-(8- (3,3...)
Show SMILES CC1(C(=O)Nc2nc(nc(NCCC(F)(F)F)c12)-c1cn2ncnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C25H19ClF8N8O2/c1-22(11-2-3-12(26)15(43)8-11)16-18(35-7-6-24(29,30)31)39-17(40-19(16)41-21(22)44)14-9-42-20(36-10-37-42)13(38-14)4-5-23(27,28)25(32,33)34/h2-3,8-10,43H,4-7H2,1H3,(H2,35,39,40,41,44)
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4.62n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463218
PNG
(4-Amino-2-(8-butylimidazo[1,2- a]pyrazin-6-yl)-5-(...)
Show SMILES CCCCc1nc(cn2ccnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1cc(O)c(Cl)cn1
Show InChI InChI=1S/C22H21ClN8O2/c1-3-4-5-12-20-25-6-7-31(20)10-13(27-12)18-28-17(24)16-19(29-18)30-21(33)22(16,2)15-8-14(32)11(23)9-26-15/h6-10H,3-5H2,1-2H3,(H,26,32)(H3,24,28,29,30,33)
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4.62n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463231
PNG
(4-Amino-2-(8-(2- cyclohexylethyl)imidazo[1,2- a]py...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CCC2CCCCC2)n1)c1ccc(O)cc1
Show InChI InChI=1S/C27H29N7O2/c1-27(17-8-10-18(35)11-9-17)21-22(28)31-23(32-24(21)33-26(27)36)20-15-34-14-13-29-25(34)19(30-20)12-7-16-5-3-2-4-6-16/h8-11,13-16,35H,2-7,12H2,1H3,(H3,28,31,32,33,36)
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4.82n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463261
PNG
(4-Amino-5-(4-fluoro-3- hydroxyphenyl)-5- methyl-2-...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(F)c(O)c1
Show InChI InChI=1S/C22H16F6N8O2/c1-20(9-2-3-10(23)13(37)6-9)14-15(29)33-16(34-17(14)35-19(20)38)12-7-36-18(30-8-31-36)11(32-12)4-5-21(24,25)22(26,27)28/h2-3,6-8,37H,4-5H2,1H3,(H3,29,33,34,35,38)
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4.95n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463262
PNG
(4-Amino-5-(4-fluoro- 3-hydroxyphenyl)-5- methyl-2-...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(F)c(O)c1
Show InChI InChI=1S/C23H17F6N7O2/c1-21(10-2-3-11(24)14(37)8-10)15-16(30)33-17(34-18(15)35-20(21)38)13-9-36-7-6-31-19(36)12(32-13)4-5-22(25,26)23(27,28)29/h2-3,6-9,37H,4-5H2,1H3,(H3,30,33,34,35,38)
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5.03n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463229
PNG
(4-Amino-2-(8-(2- cyclohexylethyl)imidazo[1,2- a]py...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CCC2CCCCC2)n1)c1cccc(O)c1
Show InChI InChI=1S/C27H29N7O2/c1-27(17-8-5-9-18(35)14-17)21-22(28)31-23(32-24(21)33-26(27)36)20-15-34-13-12-29-25(34)19(30-20)11-10-16-6-3-2-4-7-16/h5,8-9,12-16,35H,2-4,6-7,10-11H2,1H3,(H3,28,31,32,33,36)
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5.12n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463219
PNG
(4-Amino-5-(3,5-dichloro-4- hydroxypyridin-2-yl)-2-...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2)n1)c1ncc(Cl)c(O)c1Cl
Show InChI InChI=1S/C25H16Cl2F2N8O2/c1-25(19-17(27)18(38)13(26)8-32-19)16-20(30)34-21(35-22(16)36-24(25)39)15-9-37-3-2-31-23(37)14(33-15)6-10-4-11(28)7-12(29)5-10/h2-5,7-9H,6H2,1H3,(H,32,38)(H3,30,34,35,36,39)
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6.01n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463220
PNG
(4-Amino-2-(8-butyl- [1,2,4]triazolo[1,5-a]pyrazin-...)
Show SMILES CCCCc1nc(cn2ncnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(O)c(Cl)c1
Show InChI InChI=1S/C22H21ClN8O2/c1-3-4-5-13-20-25-10-26-31(20)9-14(27-13)18-28-17(24)16-19(29-18)30-21(33)22(16,2)11-6-7-15(32)12(23)8-11/h6-10,32H,3-5H2,1-2H3,(H3,24,28,29,30,33)
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6.17n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463263
PNG
(4-Amino-5-(3-fluoro-4- hydroxyphenyl)-5- methyl-2-...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(O)c(F)c1
Show InChI InChI=1S/C22H16F6N8O2/c1-20(9-2-3-13(37)10(23)6-9)14-15(29)33-16(34-17(14)35-19(20)38)12-7-36-18(30-8-31-36)11(32-12)4-5-21(24,25)22(26,27)28/h2-3,6-8,37H,4-5H2,1H3,(H3,29,33,34,35,38)
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6.38n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463221
PNG
(4-Amino-2-(8-butylimidazo[1,2- a]pyrazin-6-yl)-5-(...)
Show SMILES CCCCc1nc(cn2ccnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(O)c(Cl)c1
Show InChI InChI=1S/C23H22ClN7O2/c1-3-4-5-14-21-26-8-9-31(21)11-15(27-14)19-28-18(25)17-20(29-19)30-22(33)23(17,2)12-6-7-16(32)13(24)10-12/h6-11,32H,3-5H2,1-2H3,(H3,25,28,29,30,33)
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6.55n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463278
PNG
(5-(3-Fluoro-4-hydroxyphenyl)-4-(3-hydroxy-3-(trifl...)
Show SMILES CC1(C(=O)Nc2nc(nc(N3CC(O)(C3)C(F)(F)F)c12)-c1cn2ccnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(O)c(F)c1
Show InChI InChI=1S/C27H20F9N7O3/c1-23(12-2-3-16(44)13(28)8-12)17-19(41-22(23)45)39-18(40-21(17)43-10-24(46,11-43)26(31,32)33)15-9-42-7-6-37-20(42)14(38-15)4-5-25(29,30)27(34,35)36/h2-3,6-9,44,46H,4-5,10-11H2,1H3,(H,39,40,41,45)
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7.15n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463222
PNG
(4-Amino-2-(8-butylimidazo[1,2- a]pyrazin-6-yl)-5-(...)
Show SMILES CCCCc1nc(cn2ccnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(c(O)c1)C(F)(F)F
Show InChI InChI=1S/C24H22F3N7O2/c1-3-4-5-14-21-29-8-9-34(21)11-15(30-14)19-31-18(28)17-20(32-19)33-22(36)23(17,2)12-6-7-13(16(35)10-12)24(25,26)27/h6-11,35H,3-5H2,1-2H3,(H3,28,31,32,33,36)
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7.89n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463265
PNG
(4-Amino-2-(8-butyl- [1,2,4]triazolo[1,5-a]- pyrazi...)
Show SMILES CCCCc1nc(cn2ncnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1cc(O)ccn1
Show InChI InChI=1S/C21H21N9O2/c1-3-4-5-12-19-24-10-25-30(19)9-13(26-12)17-27-16(22)15-18(28-17)29-20(32)21(15,2)14-8-11(31)6-7-23-14/h6-10H,3-5H2,1-2H3,(H,23,31)(H3,22,27,28,29,32)
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7.95n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463244
PNG
(4-Amino-5-(5-chloro-4- hydroxypyridin-2-yl)-2-{8-[...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2c(F)cccc2F)n1)c1cc(O)c(Cl)cn1
Show InChI InChI=1S/C25H17ClF2N8O2/c1-25(18-8-17(37)12(26)9-31-18)19-20(29)33-21(34-22(19)35-24(25)38)16-10-36-6-5-30-23(36)15(32-16)7-11-13(27)3-2-4-14(11)28/h2-6,8-10H,7H2,1H3,(H,31,37)(H3,29,33,34,35,38)
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8.31n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463264
PNG
(4-Amino-5-(3-fluoro- 4-hydroxyphenyl)-5- methyl-2-...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(O)c(F)c1
Show InChI InChI=1S/C23H17F6N7O2/c1-21(10-2-3-14(37)11(24)8-10)15-16(30)33-17(34-18(15)35-20(21)38)13-9-36-7-6-31-19(36)12(32-13)4-5-22(25,26)23(27,28)29/h2-3,6-9,37H,4-5H2,1H3,(H3,30,33,34,35,38)
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8.55n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463223
PNG
(4-Amino-5-(3-chloro-4- hydroxyphenyl)-2-(8-(2- cyc...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CCC2CCCCC2)n1)c1ccc(O)c(Cl)c1
Show InChI InChI=1S/C27H28ClN7O2/c1-27(16-8-10-20(36)17(28)13-16)21-22(29)32-23(33-24(21)34-26(27)37)19-14-35-12-11-30-25(35)18(31-19)9-7-15-5-3-2-4-6-15/h8,10-15,36H,2-7,9H2,1H3,(H3,29,32,33,34,37)
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8.79n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463224
PNG
(4-Amino-5-(3-hydroxyphenyl)-5- methyl-2-(8-(3,3,4,...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CCC(F)(F)C(F)(F)F)n1)c1cccc(O)c1
Show InChI InChI=1S/C22H17F5N8O2/c1-20(10-3-2-4-11(36)7-10)14-15(28)32-16(33-17(14)34-19(20)37)13-8-35-18(29-9-30-35)12(31-13)5-6-21(23,24)22(25,26)27/h2-4,7-9,36H,5-6H2,1H3,(H3,28,32,33,34,37)
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8.88n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463283
PNG
(5-(4-Chloro-3-hydroxy- phenyl)-5-methyl-2-(8- (3,3...)
Show SMILES CC1(C(=O)Nc2nc(nc(NCC(O)C(F)(F)F)c12)-c1cn2ncnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C25H19ClF8N8O3/c1-22(10-2-3-11(26)14(43)6-10)16-18(35-7-15(44)24(29,30)31)39-17(40-19(16)41-21(22)45)13-8-42-20(36-9-37-42)12(38-13)4-5-23(27,28)25(32,33)34/h2-3,6,8-9,15,43-44H,4-5,7H2,1H3,(H2,35,39,40,41,45)
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9.24n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463225
PNG
(4-Amino-5-(3-hydroxyphenyl)-5- methyl-2-(8-(3,3,4,...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CCC(F)(F)C(F)(F)F)n1)c1cccc(O)c1
Show InChI InChI=1S/C23H18F5N7O2/c1-21(11-3-2-4-12(36)9-11)15-16(29)32-17(33-18(15)34-20(21)37)14-10-35-8-7-30-19(35)13(31-14)5-6-22(24,25)23(26,27)28/h2-4,7-10,36H,5-6H2,1H3,(H3,29,32,33,34,37)
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9.41n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463275
PNG
(4-Amino-5-(3-fluoro-4- hydroxyphenyl)-5-methyl- 2-...)
Show SMILES Cc1cccc(Cc2nc(cn3ccnc23)-c2nc3NC(=O)C(C)(c3c(N)n2)c2ccc(O)c(F)c2)c1
Show InChI InChI=1S/C27H22FN7O2/c1-14-4-3-5-15(10-14)11-18-25-30-8-9-35(25)13-19(31-18)23-32-22(29)21-24(33-23)34-26(37)27(21,2)16-6-7-20(36)17(28)12-16/h3-10,12-13,36H,11H2,1-2H3,(H3,29,32,33,34,37)
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9.72n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463226
PNG
(4-Amino-5-(4-hydroxyphenyl)-5- methyl-2-(8-(3,3,4,...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(O)cc1
Show InChI InChI=1S/C22H17F5N8O2/c1-20(10-2-4-11(36)5-3-10)14-15(28)32-16(33-17(14)34-19(20)37)13-8-35-18(29-9-30-35)12(31-13)6-7-21(23,24)22(25,26)27/h2-5,8-9,36H,6-7H2,1H3,(H3,28,32,33,34,37)
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9.98n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463267
PNG
(4-Amino-5-(3-chloro-4- hydroxyphenyl)-5- methyl-2-...)
Show SMILES CC1CCC(Cc2nc(cn3ccnc23)-c2nc3NC(=O)C(C)(c3c(N)n2)c2ccc(O)c(Cl)c2)CC1
Show InChI InChI=1S/C27H28ClN7O2/c1-14-3-5-15(6-4-14)11-18-25-30-9-10-35(25)13-19(31-18)23-32-22(29)21-24(33-23)34-26(37)27(21,2)16-7-8-20(36)17(28)12-16/h7-10,12-15,36H,3-6,11H2,1-2H3,(H3,29,32,33,34,37)
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10.9n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463227
PNG
(4-Amino-5-(4-hydroxyphenyl)-5- methyl-2-(8-(3,3,4,...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H17ClF5N7O/c1-21(11-2-4-12(24)5-3-11)15-16(30)33-17(34-18(15)35-20(21)37)14-10-36-9-8-31-19(36)13(32-14)6-7-22(25,26)23(27,28)29/h2-5,8-10H,6-7H2,1H3,(H3,30,33,34,35,37)
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13.9n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463241
PNG
(4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-(8-((4,4- ...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCC(F)(F)CC2)n1)c1ccc(Cl)c(O)c1
Show InChI InChI=1S/C26H24ClF2N7O2/c1-25(14-2-3-15(27)18(37)11-14)19-20(30)33-21(34-22(19)35-24(25)38)17-12-36-9-8-31-23(36)16(32-17)10-13-4-6-26(28,29)7-5-13/h2-3,8-9,11-13,37H,4-7,10H2,1H3,(H3,30,33,34,35,38)
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14.4n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM463270
PNG
(4-Amino-5-(3-hydroxy- phenyl)-5-methyl-2-{8- [(3-m...)
Show SMILES Cc1cccc(Cc2nc(cn3ccnc23)-c2nc3NC(=O)C(C)(c3c(N)n2)c2cccc(O)c2)c1
Show InChI InChI=1S/C27H23N7O2/c1-15-5-3-6-16(11-15)12-19-25-29-9-10-34(25)14-20(30-19)23-31-22(28)21-24(32-23)33-26(36)27(21,2)17-7-4-8-18(35)13-17/h3-11,13-14,35H,12H2,1-2H3,(H3,28,31,32,33,36)
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15.6n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10780092 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%