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Patent code US10780095

Compile Data Set for Download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prokineticin Receptor 2 (PKR2)


(Homo sapiens (Human))
BDBM463312
PNG
((-)-(2R)-1-(benzimidazol-4- ylmethyl)-N-(9-chloro-...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CN(Cc2cccc3nc[nH]c23)CCO1
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1.30n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))
BDBM463303
PNG
((-)-(2R)-1-(2-Methoxybenzyl)- N-(9-chloro-3,4-dihy...)
Show SMILES COc1ccccc1CN1CCOC(C1)C(=O)N(CC(C)C)Cc1cc(Cl)c2OCCCOc2c1
Show InChI InChI=1S/C27H35ClN2O5/c1-19(2)15-30(16-20-13-22(28)26-24(14-20)33-10-6-11-35-26)27(31)25-18-29(9-12-34-25)17-21-7-4-5-8-23(21)32-3/h4-5,7-8,13-14,19,25H,6,9-12,15-18H2,1-3H3
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1.49n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin Receptor 2 (PKR2)


(Homo sapiens (Human))
BDBM463307
PNG
((-)-(3R)-1-(benzimidazol-4- ylmethyl)-N-(9-chloro-...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCN(Cc2cccc3nc[nH]c23)C1
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1.70n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin Receptor 2 (PKR2)


(Homo sapiens (Human))
BDBM463306
PNG
((-)-(2R)-1-(4-Fluoro-3- methoxybenzyl)-N-(9-chloro...)
Show SMILES COc1cc(CN2CCOC(C2)C(=O)N(CC(C)C)Cc2cc(Cl)c3OCCCOc3c2)ccc1F
Show InChI InChI=1S/C27H34ClFN2O5/c1-18(2)14-31(16-20-11-21(28)26-24(13-20)34-8-4-9-36-26)27(32)25-17-30(7-10-35-25)15-19-5-6-22(29)23(12-19)33-3/h5-6,11-13,18,25H,4,7-10,14-17H2,1-3H3
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1.90n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin Receptor 2 (PKR2)


(Homo sapiens (Human))
BDBM463309
PNG
((+-)-2-Methyl-3-(benzimidazol- 4-ylmethylamino)-N-...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1cccc2nc[nH]c12
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2.10n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))
BDBM463304
PNG
((-)-(2R)-1-(3-Methoxybenzyl)- N-(9-chloro-3,4-dihy...)
Show SMILES COc1cccc(CN2CCOC(C2)C(=O)N(CC(C)C)Cc2cc(Cl)c3OCCCOc3c2)c1
Show InChI InChI=1S/C27H35ClN2O5/c1-19(2)15-30(17-21-13-23(28)26-24(14-21)33-9-5-10-35-26)27(31)25-18-29(8-11-34-25)16-20-6-4-7-22(12-20)32-3/h4,6-7,12-14,19,25H,5,8-11,15-18H2,1-3H3
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2.5n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))
BDBM463307
PNG
((-)-(3R)-1-(benzimidazol-4- ylmethyl)-N-(9-chloro-...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCN(Cc2cccc3nc[nH]c23)C1
MMDB

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2.60n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))
BDBM463306
PNG
((-)-(2R)-1-(4-Fluoro-3- methoxybenzyl)-N-(9-chloro...)
Show SMILES COc1cc(CN2CCOC(C2)C(=O)N(CC(C)C)Cc2cc(Cl)c3OCCCOc3c2)ccc1F
Show InChI InChI=1S/C27H34ClFN2O5/c1-18(2)14-31(16-20-11-21(28)26-24(13-20)34-8-4-9-36-26)27(32)25-17-30(7-10-35-25)15-19-5-6-22(29)23(12-19)33-3/h5-6,11-13,18,25H,4,7-10,14-17H2,1-3H3
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2.60n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin Receptor 2 (PKR2)


(Homo sapiens (Human))
BDBM463311
PNG
((-)-(3R)-1-(benzimidazol-4- ylmethyl)-N-(9-chloro-...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCCN(Cc2cccc3nc[nH]c23)C1
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3n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))
BDBM463308
PNG
((-)-(2R)-2-Methyl-3- (benzimidazol-4- ylmethylamin...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1cccc2nc[nH]c12
MMDB

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3.5n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))
BDBM463321
PNG
((-)-(2R)-1-(4,6-Difluoro-3- methoxybenzyl)-N-(9-ch...)
Show SMILES COc1cc(CN2CCOC(C2)C(=O)N(CC(C)C)Cc2cc(Cl)c3OCCCOc3c2)c(F)cc1F
Show InChI InChI=1S/C27H33ClF2N2O5/c1-17(2)13-32(14-18-9-20(28)26-24(10-18)35-6-4-7-37-26)27(33)25-16-31(5-8-36-25)15-19-11-23(34-3)22(30)12-21(19)29/h9-12,17,25H,4-8,13-16H2,1-3H3
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4.09n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))
BDBM463326
PNG
((+-)-2-Methyl-3-((3-hydroxy-4- fluoro)benzylamino)...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1ccc(F)c(O)c1
Show InChI InChI=1S/C25H32ClFN2O4/c1-16(2)14-29(15-19-9-20(26)24-23(11-19)32-7-4-8-33-24)25(31)17(3)12-28-13-18-5-6-21(27)22(30)10-18/h5-6,9-11,16-17,28,30H,4,7-8,12-15H2,1-3H3
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4.40n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))
BDBM463309
PNG
((+-)-2-Methyl-3-(benzimidazol- 4-ylmethylamino)-N-...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1cccc2nc[nH]c12
MMDB

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5.60n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))
BDBM463316
PNG
((-)-(3R)-1-(4,6-Difluoro-3- methoxybenzyl)-N-(9-ch...)
Show SMILES COc1cc(CN2CCC(C2)C(=O)N(CC(C)C)Cc2cc(Cl)c3OCCCOc3c2)c(F)cc1F
Show InChI InChI=1S/C27H33ClF2N2O4/c1-17(2)13-32(14-18-9-21(28)26-25(10-18)35-7-4-8-36-26)27(33)19-5-6-31(15-19)16-20-11-24(34-3)23(30)12-22(20)29/h9-12,17,19H,4-8,13-16H2,1-3H3
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6.14n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))
BDBM463313
PNG
((-)-(2R)-1-(5-fluro- benzimidazol-4-ylmethyl)-N- (...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CN(Cc2cc(F)cc3nc[nH]c23)CCO1
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6.14n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))
BDBM463325
PNG
((-)-(2R)-1-(5-Fluoro-2- methoxybenzyl)-N-(9-chloro...)
Show SMILES COc1ccc(F)cc1CN1CCOC(C1)C(=O)N(CC(C)C)Cc1cc(Cl)c2OCCCOc2c1
Show InChI InChI=1S/C27H34ClFN2O5/c1-18(2)14-31(15-19-11-22(28)26-24(12-19)34-8-4-9-36-26)27(32)25-17-30(7-10-35-25)16-20-13-21(29)5-6-23(20)33-3/h5-6,11-13,18,25H,4,7-10,14-17H2,1-3H3
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7.30n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))
BDBM463305
PNG
((-)-(2R)-1-(4-Fluoro-2- methoxybenzyl)-N-(9-chloro...)
Show SMILES COc1cc(F)ccc1CN1CCOC(C1)C(=O)N(CC(C)C)Cc1cc(Cl)c2OCCCOc2c1
Show InChI InChI=1S/C27H34ClFN2O5/c1-18(2)14-31(15-19-11-22(28)26-24(12-19)34-8-4-9-36-26)27(32)25-17-30(7-10-35-25)16-20-5-6-21(29)13-23(20)33-3/h5-6,11-13,18,25H,4,7-10,14-17H2,1-3H3
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7.30n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))
BDBM463312
PNG
((-)-(2R)-1-(benzimidazol-4- ylmethyl)-N-(9-chloro-...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CN(Cc2cccc3nc[nH]c23)CCO1
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8.40n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))
BDBM463319
PNG
((-)-(3R)-1-(5-Fluoro-2- methoxybenzyl)-N-(9-chloro...)
Show SMILES COc1ccc(F)cc1CN1CCC(C1)C(=O)N(CC(C)C)Cc1cc(Cl)c2OCCCOc2c1
Show InChI InChI=1S/C27H34ClFN2O4/c1-18(2)14-31(15-19-11-23(28)26-25(12-19)34-9-4-10-35-26)27(32)20-7-8-30(16-20)17-21-13-22(29)5-6-24(21)33-3/h5-6,11-13,18,20H,4,7-10,14-17H2,1-3H3
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9.30n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))
BDBM463315
PNG
((-)-(3R)-1-(4-Fluoro-2- methoxybenzyl)-N-(9-chloro...)
Show SMILES COc1cc(F)ccc1CN1CCC(C1)C(=O)N(CC(C)C)Cc1cc(Cl)c2OCCCOc2c1
Show InChI InChI=1S/C27H34ClFN2O4/c1-18(2)14-31(15-19-11-23(28)26-25(12-19)34-9-4-10-35-26)27(32)21-7-8-30(17-21)16-20-5-6-22(29)13-24(20)33-3/h5-6,11-13,18,21H,4,7-10,14-17H2,1-3H3
MMDB

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9.32n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))
BDBM463324
PNG
((-)-(2R)-1-(6-Fluoro-3- methoxybenzyl)-N-(9-chloro...)
Show SMILES COc1ccc(F)c(CN2CCOC(C2)C(=O)N(CC(C)C)Cc2cc(Cl)c3OCCCOc3c2)c1
Show InChI InChI=1S/C27H34ClFN2O5/c1-18(2)14-31(15-19-11-22(28)26-24(12-19)34-8-4-9-36-26)27(32)25-17-30(7-10-35-25)16-20-13-21(33-3)5-6-23(20)29/h5-6,11-13,18,25H,4,7-10,14-17H2,1-3H3
MMDB

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10n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))
BDBM463323
PNG
((-)-(3R)-1-(4,6-Difluoro-3- methoxybenzyl)-N-(9-ch...)
Show SMILES COc1cc(CN2CCCC(C2)C(=O)N(CC(C)C)Cc2cc(Cl)c3OCCCOc3c2)c(F)cc1F
Show InChI InChI=1S/C28H35ClF2N2O4/c1-18(2)14-33(15-19-10-22(29)27-26(11-19)36-8-5-9-37-27)28(34)20-6-4-7-32(16-20)17-21-12-25(35-3)24(31)13-23(21)30/h10-13,18,20H,4-9,14-17H2,1-3H3
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13.8n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))
BDBM463320
PNG
((-)-(3R)-1-(5-Fluoro-3- methoxybenzyl)-N-(9-chloro...)
Show SMILES COc1cc(F)cc(CN2CCC(C2)C(=O)N(CC(C)C)Cc2cc(Cl)c3OCCCOc3c2)c1
Show InChI InChI=1S/C27H34ClFN2O4/c1-18(2)14-31(16-20-11-24(28)26-25(12-20)34-7-4-8-35-26)27(32)21-5-6-30(17-21)15-19-9-22(29)13-23(10-19)33-3/h9-13,18,21H,4-8,14-17H2,1-3H3
MMDB

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41.5n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))
BDBM463322
PNG
((+-)-2-Methyl-3-((3-methoxy- 4,6-difluoro)benzylam...)
Show SMILES COc1cc(CNCC(C)C(=O)N(CC(C)C)Cc2cc(Cl)c3OCCCOc3c2)c(F)cc1F
Show InChI InChI=1S/C26H33ClF2N2O4/c1-16(2)14-31(15-18-8-20(27)25-24(9-18)34-6-5-7-35-25)26(32)17(3)12-30-13-19-10-23(33-4)22(29)11-21(19)28/h8-11,16-17,30H,5-7,12-15H2,1-4H3
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43.5n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))
BDBM463310
PNG
((-)-(3R)-1-(5-fluro- benzimidazol-4-ylmethyl)-N- (...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCN(Cc2cc(F)cc3nc[nH]c23)C1
MMDB

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71.3n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))
BDBM463311
PNG
((-)-(3R)-1-(benzimidazol-4- ylmethyl)-N-(9-chloro-...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCCN(Cc2cccc3nc[nH]c23)C1
MMDB

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97n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))
BDBM463327
PNG
((-)-(3R)-1-(4-Fluoro-3- hydroxybenzyl)-N-(9-chloro...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCN(Cc2ccc(F)c(O)c2)C1
Show InChI InChI=1S/C26H32ClFN2O4/c1-17(2)13-30(15-19-10-21(27)25-24(12-19)33-8-3-9-34-25)26(32)20-6-7-29(16-20)14-18-4-5-22(28)23(31)11-18/h4-5,10-12,17,20,31H,3,6-9,13-16H2,1-2H3
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107n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))
BDBM463314
PNG
((-)-(3R)-1-(3-Fluoro-2- methoxybenzyl)-N-(9-chloro...)
Show SMILES COc1c(F)cccc1CN1CCC(C1)C(=O)N(CC(C)C)Cc1cc(Cl)c2OCCCOc2c1
Show InChI InChI=1S/C27H34ClFN2O4/c1-18(2)14-31(15-19-12-22(28)26-24(13-19)34-10-5-11-35-26)27(32)21-8-9-30(17-21)16-20-6-4-7-23(29)25(20)33-3/h4,6-7,12-13,18,21H,5,8-11,14-17H2,1-3H3
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170n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))
BDBM463317
PNG
((-)-(3R)-1-(6-Fluoro-3- methoxybenzyl)-N-(9-chloro...)
Show SMILES COc1ccc(F)c(CN2CCC(C2)C(=O)N(CC(C)C)Cc2cc(Cl)c3OCCCOc3c2)c1
Show InChI InChI=1S/C27H34ClFN2O4/c1-18(2)14-31(15-19-11-23(28)26-25(12-19)34-9-4-10-35-26)27(32)20-7-8-30(16-20)17-21-13-22(33-3)5-6-24(21)29/h5-6,11-13,18,20H,4,7-10,14-17H2,1-3H3
MMDB

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301n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))
BDBM463318
PNG
((-)-(3R)-1-(5-Fluoro-3- methoxybenzyl)-N-(9-chloro...)
Show SMILES COc1cc(F)cc(CN2CCC(C2)C(=O)N(CC(C)C)Cc2cc(Cl)c3OCCCOc3c2)c1
Show InChI InChI=1S/C27H34ClFN2O4/c1-18(2)14-31(16-20-11-24(28)26-25(12-20)34-7-4-8-35-26)27(32)21-5-6-30(17-21)15-19-9-22(29)13-23(10-19)33-3/h9-13,18,21H,4-8,14-17H2,1-3H3
MMDB

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373n/an/an/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US10780095 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%