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Patent code US10781204

Compile Data Set for Download or QSAR

Found 378 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463591
PNG
(US10781204, Compound I-111 | US10781204, Compound ...)
Show SMILES C[C@@]1(O)CCCN(C1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C23H21FN6O2/c1-23(32)7-3-8-29(13-23)19-6-9-30(28-19)18-10-16(27-17-12-26-22(31)21(17)18)20-14(11-25)4-2-5-15(20)24/h2,4-6,9-10,32H,3,7-8,12-13H2,1H3,(H,26,31)/t23-/m1/s1
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0.0500n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463752
PNG
(US10781204, Compound I-229)
Show SMILES CO[C@H]1CCN(C[C@@]1(C)O)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C24H23FN6O3/c1-24(33)13-30(8-6-19(24)34-2)20-7-9-31(29-20)18-10-16(28-17-12-27-23(32)22(17)18)21-14(11-26)4-3-5-15(21)25/h3-5,7,9-10,19,33H,6,8,12-13H2,1-2H3,(H,27,32)/t19-,24+/m0/s1
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0.0500n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463696
PNG
(US10781204, Compound I-173)
Show SMILES O[C@H]1CN(CC[C@H]1F)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C22H18F2N6O2/c23-13-4-6-29(11-18(13)31)19-5-7-30(28-19)17-8-15(27-16-10-26-22(32)21(16)17)20-12(9-25)2-1-3-14(20)24/h1-3,5,7-8,13,18,31H,4,6,10-11H2,(H,26,32)/t13-,18+/m1/s1
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463639
PNG
(US10781204, Compound I-118)
Show SMILES N[C@]1(CCCN(C1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N)C(F)(F)F
Show InChI InChI=1S/C23H19F4N7O/c24-14-4-1-3-13(10-28)19(14)15-9-17(20-16(31-15)11-30-21(20)35)34-8-5-18(32-34)33-7-2-6-22(29,12-33)23(25,26)27/h1,3-5,8-9H,2,6-7,11-12,29H2,(H,30,35)/t22-/m0/s1
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463640
PNG
(US10781204, Compound I-119)
Show SMILES N[C@@]1(CCCN(C1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N)C(F)(F)F
Show InChI InChI=1S/C23H19F4N7O/c24-14-4-1-3-13(10-28)19(14)15-9-17(20-16(31-15)11-30-21(20)35)34-8-5-18(32-34)33-7-2-6-22(29,12-33)23(25,26)27/h1,3-5,8-9H,2,6-7,11-12,29H2,(H,30,35)/t22-/m1/s1
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463662
PNG
(US10781204, Compound I-141)
Show SMILES Fc1cccc(C#N)c1-c1cc(c2C(=O)NCc2n1)-n1ccc(n1)N1CCNC(=O)CC1
Show InChI InChI=1S/C22H18FN7O2/c23-14-3-1-2-13(11-24)20(14)15-10-17(21-16(27-15)12-26-22(21)32)30-8-4-18(28-30)29-7-5-19(31)25-6-9-29/h1-4,8,10H,5-7,9,12H2,(H,25,31)(H,26,32)
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0.0500n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463672
PNG
(US10781204, Compound I-150)
Show SMILES C[C@H]1[C@H](O)CCN1c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C22H19FN6O2/c1-12-18(30)5-7-28(12)19-6-8-29(27-19)17-9-15(26-16-11-25-22(31)21(16)17)20-13(10-24)3-2-4-14(20)23/h2-4,6,8-9,12,18,30H,5,7,11H2,1H3,(H,25,31)/t12-,18+/m0/s1
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463609
PNG
(US10781204, Compound I-88)
Show SMILES O[C@@]1(CCCN(C1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N)C(F)(F)F
Show InChI InChI=1S/C23H18F4N6O2/c24-14-4-1-3-13(10-28)19(14)15-9-17(20-16(30-15)11-29-21(20)34)33-8-5-18(31-33)32-7-2-6-22(35,12-32)23(25,26)27/h1,3-5,8-9,35H,2,6-7,11-12H2,(H,29,34)/t22-/m1/s1
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463657
PNG
(US10781204, Compound I-136)
Show SMILES O[C@H]1CCN(C[C@H]1O)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C22H19FN6O3/c23-13-3-1-2-12(9-24)20(13)14-8-16(21-15(26-14)10-25-22(21)32)29-7-5-19(27-29)28-6-4-17(30)18(31)11-28/h1-3,5,7-8,17-18,30-31H,4,6,10-11H2,(H,25,32)/t17-,18+/m0/s1
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463684
PNG
(US10781204, Compound I-162)
Show SMILES C[C@]1(O)CN(CC[C@H]1O)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C23H21FN6O3/c1-23(33)12-29(7-5-18(23)31)19-6-8-30(28-19)17-9-15(27-16-11-26-22(32)21(16)17)20-13(10-25)3-2-4-14(20)24/h2-4,6,8-9,18,31,33H,5,7,11-12H2,1H3,(H,26,32)/t18-,23+/m1/s1
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463582
PNG
(US10781204, Compound I-186 | US10781204, Compound ...)
Show SMILES CC1(O)CCCN(C1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C23H21FN6O2/c1-23(32)7-3-8-29(13-23)19-6-9-30(28-19)18-10-16(27-17-12-26-22(31)21(17)18)20-14(11-25)4-2-5-15(20)24/h2,4-6,9-10,32H,3,7-8,12-13H2,1H3,(H,26,31)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463605
PNG
(US10781204, Compound I-84)
Show SMILES NC1(CCCN(C1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N)C(F)(F)F
Show InChI InChI=1S/C23H19F4N7O/c24-14-4-1-3-13(10-28)19(14)15-9-17(20-16(31-15)11-30-21(20)35)34-8-5-18(32-34)33-7-2-6-22(29,12-33)23(25,26)27/h1,3-5,8-9H,2,6-7,11-12,29H2,(H,30,35)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463621
PNG
(US10781204, Compound I-100)
Show SMILES Fc1cccc(C#N)c1-c1cc(c2C(=O)NCc2n1)-n1ccc(n1)N1CCC2(C1)OCCO2
Show InChI InChI=1S/C23H19FN6O3/c24-15-3-1-2-14(11-25)20(15)16-10-18(21-17(27-16)12-26-22(21)31)30-6-4-19(28-30)29-7-5-23(13-29)32-8-9-33-23/h1-4,6,10H,5,7-9,12-13H2,(H,26,31)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463682
PNG
(US10781204, Compound I-160)
Show SMILES OC1CN(CCC1F)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C22H18F2N6O2/c23-13-4-6-29(11-18(13)31)19-5-7-30(28-19)17-8-15(27-16-10-26-22(32)21(16)17)20-12(9-25)2-1-3-14(20)24/h1-3,5,7-8,13,18,31H,4,6,10-11H2,(H,26,32)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463711
PNG
(US10781204, Compound I-188)
Show SMILES Fc1cccc(C#N)c1-c1cc(c2C(=O)NCc2n1)-n1ccc(n1)N1C[C@@H]2CC[C@H](C1)O2
Show InChI InChI=1S/C23H19FN6O2/c24-16-3-1-2-13(9-25)21(16)17-8-19(22-18(27-17)10-26-23(22)31)30-7-6-20(28-30)29-11-14-4-5-15(12-29)32-14/h1-3,6-8,14-15H,4-5,10-12H2,(H,26,31)/t14-,15+
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463671
PNG
(US10781204, Compound I-149)
Show SMILES Fc1cccc(C#N)c1-c1cc(c2C(=O)NCc2n1)-n1ccc(n1)N1CCCC(C1)N1CCOCC1
Show InChI InChI=1S/C26H26FN7O2/c27-19-5-1-3-17(14-28)24(19)20-13-22(25-21(30-20)15-29-26(25)35)34-8-6-23(31-34)33-7-2-4-18(16-33)32-9-11-36-12-10-32/h1,3,5-6,8,13,18H,2,4,7,9-12,15-16H2,(H,29,35)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463710
PNG
(US10781204, Compound I-187)
Show SMILES CC1(C)C(O)CCN1c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C23H21FN6O2/c1-23(2)18(31)6-8-29(23)19-7-9-30(28-19)17-10-15(27-16-12-26-22(32)21(16)17)20-13(11-25)4-3-5-14(20)24/h3-5,7,9-10,18,31H,6,8,12H2,1-2H3,(H,26,32)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463596
PNG
(US10781204, Compound I-194 | US10781204, Compound ...)
Show SMILES OC1CCN(C1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C21H17FN6O2/c22-14-3-1-2-12(9-23)19(14)15-8-17(20-16(25-15)10-24-21(20)30)28-7-5-18(26-28)27-6-4-13(29)11-27/h1-3,5,7-8,13,29H,4,6,10-11H2,(H,24,30)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463736
PNG
(US10781204, Compound I-213 | US10781204, Compound ...)
Show SMILES CO[C@@H]1CCN(C[C@]1(C)O)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C24H23FN6O3/c1-24(33)13-30(8-6-19(24)34-2)20-7-9-31(29-20)18-10-16(28-17-12-27-23(32)22(17)18)21-14(11-26)4-3-5-15(21)25/h3-5,7,9-10,19,33H,6,8,12-13H2,1-2H3,(H,27,32)/t19-,24+/m1/s1
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463600
PNG
(US10781204, Compound I-142 | US10781204, Compound ...)
Show SMILES O[C@H]1CCN(C1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C21H17FN6O2/c22-14-3-1-2-12(9-23)19(14)15-8-17(20-16(25-15)10-24-21(20)30)28-7-5-18(26-28)27-6-4-13(29)11-27/h1-3,5,7-8,13,29H,4,6,10-11H2,(H,24,30)/t13-/m0/s1
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0.0500n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463689
PNG
(US10781204, Compound I-166)
Show SMILES Fc1cccc(C#N)c1-c1cc(c2C(=O)NCc2n1)-n1ccc(n1)N1CC[C@@]2(CCNC2=O)C1
Show InChI InChI=1S/C24H20FN7O2/c25-15-3-1-2-14(11-26)20(15)16-10-18(21-17(29-16)12-28-22(21)33)32-8-4-19(30-32)31-9-6-24(13-31)5-7-27-23(24)34/h1-4,8,10H,5-7,9,12-13H2,(H,27,34)(H,28,33)/t24-/m0/s1
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0.0500n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM463579
PNG
(US10781204, Compound I-59)
Show SMILES Fc1cccc(Cl)c1-c1cc(c2C(=O)NCc2n1)-n1ccc(n1)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C25H26ClFN6O2/c26-17-2-1-3-18(27)23(17)19-14-21(24-20(29-19)15-28-25(24)34)33-9-6-22(30-33)32-7-4-16(5-8-32)31-10-12-35-13-11-31/h1-3,6,9,14,16H,4-5,7-8,10-13,15H2,(H,28,34)
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5n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463583
PNG
(US10781204, Compound I-63)
Show SMILES Fc1cccc(C#N)c1-c1cc(c2C(=O)NCc2n1)-n1ccc(NCCN2CCOCC2)n1
Show InChI InChI=1S/C23H22FN7O2/c24-16-3-1-2-15(13-25)21(16)17-12-19(22-18(28-17)14-27-23(22)32)31-6-4-20(29-31)26-5-7-30-8-10-33-11-9-30/h1-4,6,12H,5,7-11,14H2,(H,26,29)(H,27,32)
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5n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463617
PNG
(US10781204, Compound I-96)
Show SMILES CC1CCC(O)CN1c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C23H21FN6O2/c1-13-5-6-15(31)12-29(13)20-7-8-30(28-20)19-9-17(27-18-11-26-23(32)22(18)19)21-14(10-25)3-2-4-16(21)24/h2-4,7-9,13,15,31H,5-6,11-12H2,1H3,(H,26,32)
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5n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM463621
PNG
(US10781204, Compound I-100)
Show SMILES Fc1cccc(C#N)c1-c1cc(c2C(=O)NCc2n1)-n1ccc(n1)N1CCC2(C1)OCCO2
Show InChI InChI=1S/C23H19FN6O3/c24-15-3-1-2-14(11-25)20(15)16-10-18(21-17(27-16)12-26-22(21)31)30-6-4-19(28-30)29-7-5-23(13-29)32-8-9-33-23/h1-4,6,10H,5,7-9,12-13H2,(H,26,31)
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5n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM463630
PNG
(US10781204, Compound I-109)
Show SMILES O[C@H]1CN(C[C@H]1O)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C21H17FN6O3/c22-12-3-1-2-11(7-23)19(12)13-6-15(20-14(25-13)8-24-21(20)31)28-5-4-18(26-28)27-9-16(29)17(30)10-27/h1-6,16-17,29-30H,8-10H2,(H,24,31)/t16-,17+
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5n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463637
PNG
(US10781204, Compound I-116)
Show SMILES Fc1cccc(C#N)c1-c1cc(c2C(=O)NCc2n1)-n1ccc(n1)N1CCC(C1)C#N
Show InChI InChI=1S/C22H16FN7O/c23-15-3-1-2-14(10-25)20(15)16-8-18(21-17(27-16)11-26-22(21)31)30-7-5-19(28-30)29-6-4-13(9-24)12-29/h1-3,5,7-8,13H,4,6,11-12H2,(H,26,31)
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5n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463638
PNG
(US10781204, Compound I-117)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Oc1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C25H25FN6O2/c1-31(2)16-6-8-17(9-7-16)34-22-10-11-32(30-22)21-12-19(29-20-14-28-25(33)24(20)21)23-15(13-27)4-3-5-18(23)26/h3-5,10-12,16-17H,6-9,14H2,1-2H3,(H,28,33)/t16-,17-
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5n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463647
PNG
(US10781204, Compound I-126)
Show SMILES NC(=O)[C@H]1CCCN(C1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C23H20FN7O2/c24-15-5-1-3-13(10-25)20(15)16-9-18(21-17(28-16)11-27-23(21)33)31-8-6-19(29-31)30-7-2-4-14(12-30)22(26)32/h1,3,5-6,8-9,14H,2,4,7,11-12H2,(H2,26,32)(H,27,33)/t14-/m0/s1
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5n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463654
PNG
(US10781204, Compound I-133)
Show SMILES CC1(CCCN(C1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N)C#N
Show InChI InChI=1S/C24H20FN7O/c1-24(13-27)7-3-8-31(14-24)20-6-9-32(30-20)19-10-17(29-18-12-28-23(33)22(18)19)21-15(11-26)4-2-5-16(21)25/h2,4-6,9-10H,3,7-8,12,14H2,1H3,(H,28,33)
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5n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463626
PNG
(US10781204, Compound I-105 | US10781204, Compound ...)
Show SMILES O[C@@H]1CCN(C[C@@H]1O)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C22H19FN6O3/c23-13-3-1-2-12(9-24)20(13)14-8-16(21-15(26-14)10-25-22(21)32)29-7-5-19(27-29)28-6-4-17(30)18(31)11-28/h1-3,5,7-8,17-18,30-31H,4,6,10-11H2,(H,25,32)/t17-,18+/m1/s1
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5n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM463671
PNG
(US10781204, Compound I-149)
Show SMILES Fc1cccc(C#N)c1-c1cc(c2C(=O)NCc2n1)-n1ccc(n1)N1CCCC(C1)N1CCOCC1
Show InChI InChI=1S/C26H26FN7O2/c27-19-5-1-3-17(14-28)24(19)20-13-22(25-21(30-20)15-29-26(25)35)34-8-6-23(31-34)33-7-2-4-18(16-33)32-9-11-36-12-10-32/h1,3,5-6,8,13,18H,2,4,7,9-12,15-16H2,(H,29,35)
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5n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463673
PNG
(US10781204, Compound I-151)
Show SMILES CC(C)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C20H16FN5O/c1-11(2)14-6-7-26(25-14)17-8-15(24-16-10-23-20(27)19(16)17)18-12(9-22)4-3-5-13(18)21/h3-8,11H,10H2,1-2H3,(H,23,27)
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5n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463680
PNG
(US10781204, Compound I-158)
Show SMILES Fc1cccc(C#N)c1-c1cc(c2C(=O)NCc2n1)-n1ccc(n1)N1CCC[C@H](C1)N1CCOCC1
Show InChI InChI=1S/C26H26FN7O2/c27-19-5-1-3-17(14-28)24(19)20-13-22(25-21(30-20)15-29-26(25)35)34-8-6-23(31-34)33-7-2-4-18(16-33)32-9-11-36-12-10-32/h1,3,5-6,8,13,18H,2,4,7,9-12,15-16H2,(H,29,35)/t18-/m1/s1
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM463682
PNG
(US10781204, Compound I-160)
Show SMILES OC1CN(CCC1F)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C22H18F2N6O2/c23-13-4-6-29(11-18(13)31)19-5-7-30(28-19)17-8-15(27-16-10-26-22(32)21(16)17)20-12(9-25)2-1-3-14(20)24/h1-3,5,7-8,13,18,31H,4,6,10-11H2,(H,26,32)
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5n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM463688
PNG
(US10781204, Compound I-165)
Show SMILES Fc1cccc(C#N)c1-c1cc(c2C(=O)NCc2n1)-n1ccc(n1)N1CC[C@]2(CCNC2=O)C1
Show InChI InChI=1S/C24H20FN7O2/c25-15-3-1-2-14(11-26)20(15)16-10-18(21-17(29-16)12-28-22(21)33)32-8-4-19(30-32)31-9-6-24(13-31)5-7-27-23(24)34/h1-4,8,10H,5-7,9,12-13H2,(H,27,34)(H,28,33)/t24-/m1/s1
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5n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463691
PNG
(US10781204, Compound I-168)
Show SMILES Fc1cccc(C#N)c1-c1cc(c2C(=O)NCc2n1)-n1ccc(n1)N1CCC[C@@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C27H26FN7O2/c28-19-7-3-5-17(14-29)24(19)20-13-22(25-21(31-20)15-30-26(25)36)35-12-8-23(32-35)34-11-4-6-18(16-34)27(37)33-9-1-2-10-33/h3,5,7-8,12-13,18H,1-2,4,6,9-11,15-16H2,(H,30,36)/t18-/m0/s1
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM463692
PNG
(US10781204, Compound I-169)
Show SMILES Fc1cccc(C#N)c1-c1cc(c2C(=O)NCc2n1)-n1ccc(n1)N1C[C@H]2OCCO[C@H]2C1
Show InChI InChI=1S/C23H19FN6O3/c24-14-3-1-2-13(9-25)21(14)15-8-17(22-16(27-15)10-26-23(22)31)30-5-4-20(28-30)29-11-18-19(12-29)33-7-6-32-18/h1-5,8,18-19H,6-7,10-12H2,(H,26,31)/t18-,19+
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5n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM463696
PNG
(US10781204, Compound I-173)
Show SMILES O[C@H]1CN(CC[C@H]1F)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C22H18F2N6O2/c23-13-4-6-29(11-18(13)31)19-5-7-30(28-19)17-8-15(27-16-10-26-22(32)21(16)17)20-12(9-25)2-1-3-14(20)24/h1-3,5,7-8,13,18,31H,4,6,10-11H2,(H,26,32)/t13-,18+/m1/s1
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5n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463614
PNG
(US10781204, Compound I-183 | US10781204, Compound ...)
Show SMILES C[C@]1(O)CCN(C1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C22H19FN6O2/c1-22(31)6-8-28(12-22)18-5-7-29(27-18)17-9-15(26-16-11-25-21(30)20(16)17)19-13(10-24)3-2-4-14(19)23/h2-5,7,9,31H,6,8,11-12H2,1H3,(H,25,30)/t22-/m0/s1
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5n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM463613
PNG
(US10781204, Compound I-184 | US10781204, Compound ...)
Show SMILES C[C@@]1(O)CCN(C1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C22H19FN6O2/c1-22(31)6-8-28(12-22)18-5-7-29(27-18)17-9-15(26-16-11-25-21(30)20(16)17)19-13(10-24)3-2-4-14(19)23/h2-5,7,9,31H,6,8,11-12H2,1H3,(H,25,30)/t22-/m1/s1
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5n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM463715
PNG
(US10781204, Compound I-192)
Show SMILES OC1COC2(CCN(C2)c2ccn(n2)-c2cc(nc3CNC(=O)c23)-c2c(F)cccc2C#N)OC1
Show InChI InChI=1S/C24H21FN6O4/c25-16-3-1-2-14(9-26)21(16)17-8-19(22-18(28-17)10-27-23(22)33)31-6-4-20(29-31)30-7-5-24(13-30)34-11-15(32)12-35-24/h1-4,6,8,15,32H,5,7,10-13H2,(H,27,33)
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5n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM463716
PNG
(US10781204, Compound I-193 | US10781204, Compound ...)
Show SMILES CO[C@@H]1CCN(C[C@H]1O)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C23H21FN6O3/c1-33-19-5-7-29(12-18(19)31)20-6-8-30(28-20)17-9-15(27-16-11-26-23(32)22(16)17)21-13(10-25)3-2-4-14(21)24/h2-4,6,8-9,18-19,31H,5,7,11-12H2,1H3,(H,26,32)/t18-,19-/m1/s1
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5n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463718
PNG
(US10781204, Compound I-195 | US10781204, Compound ...)
Show SMILES CO[C@@H]1CN(CC[C@H]1O)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C23H21FN6O3/c1-33-19-12-29(7-5-18(19)31)20-6-8-30(28-20)17-9-15(27-16-11-26-23(32)22(16)17)21-13(10-25)3-2-4-14(21)24/h2-4,6,8-9,18-19,31H,5,7,11-12H2,1H3,(H,26,32)/t18-,19-/m1/s1
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5n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463740
PNG
(US10781204, Compound I-217)
Show SMILES O[C@@H]1CN(CC[C@H]1C#N)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C23H18FN7O2/c24-15-3-1-2-14(10-26)21(15)16-8-18(22-17(28-16)11-27-23(22)33)31-7-5-20(29-31)30-6-4-13(9-25)19(32)12-30/h1-3,5,7-8,13,19,32H,4,6,11-12H2,(H,27,33)/t13-,19+/m0/s1
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5n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463741
PNG
(US10781204, Compound I-218)
Show SMILES O[C@@H]1CCN(C[C@@H]1N1CCOCC1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C26H26FN7O3/c27-17-3-1-2-16(13-28)24(17)18-12-20(25-19(30-18)14-29-26(25)36)34-7-5-23(31-34)33-6-4-22(35)21(15-33)32-8-10-37-11-9-32/h1-3,5,7,12,21-22,35H,4,6,8-11,14-15H2,(H,29,36)/t21-,22+/m0/s1
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5n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463744
PNG
(US10781204, Compound I-221)
Show SMILES O[C@H]1CO[C@@]2(CCN(C2)c2ccn(n2)-c2cc(nc3CNC(=O)c23)-c2c(F)cccc2C#N)OC1
Show InChI InChI=1S/C24H21FN6O4/c25-16-3-1-2-14(9-26)21(16)17-8-19(22-18(28-17)10-27-23(22)33)31-6-4-20(29-31)30-7-5-24(13-30)34-11-15(32)12-35-24/h1-4,6,8,15,32H,5,7,10-13H2,(H,27,33)/t15-,24-
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5n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463736
PNG
(US10781204, Compound I-213 | US10781204, Compound ...)
Show SMILES CO[C@@H]1CCN(C[C@]1(C)O)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C24H23FN6O3/c1-24(33)13-30(8-6-19(24)34-2)20-7-9-31(29-20)18-10-16(28-17-12-27-23(32)22(17)18)21-14(11-26)4-3-5-15(21)25/h3-5,7,9-10,19,33H,6,8,12-13H2,1-2H3,(H,27,32)/t19-,24+/m1/s1
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5n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM463758
PNG
(US10781204, Compound I-235)
Show SMILES OC1CNc2cc(nn2C1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C20H15FN6O2/c21-13-3-1-2-10(6-22)18(13)15-4-12(19-16(25-15)8-24-20(19)29)14-5-17-23-7-11(28)9-27(17)26-14/h1-5,11,23,28H,7-9H2,(H,24,29)
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5n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM463581
PNG
(US10781204, Compound I-61)
Show SMILES CC(C)n1cc(cn1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N
Show InChI InChI=1S/C20H16FN5O/c1-11(2)26-10-13(8-24-26)14-6-16(25-17-9-23-20(27)19(14)17)18-12(7-22)4-3-5-15(18)21/h3-6,8,10-11H,9H2,1-2H3,(H,23,27)
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5n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10781204 (2020)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%