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Patent code US10781209

Compile Data Set for Download or QSAR
Found 196 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391502
PNG
(2-isopropyl-8-(6-methyl-7- | US10472358, Example 2...)
Show SMILES CC(C)C1Oc2c(NC1=O)cccc2-c1cn(C)c(=O)c2[nH]ccc12
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391522
PNG
(US10472358, Example 20 | US10781209, Example 20 | ...)
Show SMILES CNC(=O)c1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391539
PNG
(US10472358, Example 35B | US10781209, Example 35 |...)
Show SMILES COc1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C1CCCC1
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463798
PNG
(US10781209, Example 35A)
Show SMILES COc1cc2NC(=O)[C@@H](Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C1CCCC1
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391548
PNG
(US10472358, Example 42B | US10781209, Example 42B ...)
Show SMILES COc1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ncc12)C1CCCC1
PDB

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Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391572
PNG
((3S)-3-isopropyl-5-(6-methyl-7- oxo-6,7-dihydro-1H...)
Show SMILES CC(C)[C@@H]1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)S(C)(=O)=O
PDB

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Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391555
PNG
(2,2-dimethyl-8-(6-methyl-7- | US10781209, Example ...)
Show SMILES Cn1cc(-c2cc(cc3NC(=O)C(C)(C)Oc23)S(C)(=O)=O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C19H19N3O5S/c1-19(2)18(24)21-14-8-10(28(4,25)26)7-12(16(14)27-19)13-9-22(3)17(23)15-11(13)5-6-20-15/h5-9,20H,1-4H3,(H,21,24)
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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463819
PNG
(6-acetyl-2-isopropyl-8-(6- methyl-7-oxo-6,7-dihydr...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)C(O)=O
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM419989
PNG
(4-ethyl-2-isopropyl-8-(6- methyl-7-oxo-6,7-dihydro...)
Show SMILES CCN1C(=O)C(Oc2c1cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)S(C)(=O)=O)C(C)C
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM419990
PNG
(6-(ethylsulfonyl)-2-isopropyl- 4-methyl-8-(6-methy...)
Show SMILES CCS(=O)(=O)c1cc2N(C)C(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391568
PNG
(2-isopropyl-6- (isopropylsulfonyl)-4-methyl- 8-(6-...)
Show SMILES CC(C)C1Oc2c(cc(cc2-c2cn(C)c(=O)c3[nH]ccc23)S(=O)(=O)C(C)C)N(C)C1=O
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391570
PNG
(US10472358, Example 58 | US10781209, Example 58 | ...)
Show SMILES Cn1cc(-c2cc(cc3NC(=O)C(C)(C)Nc23)S(C)(=O)=O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C19H20N4O4S/c1-19(2)18(25)21-14-8-10(28(4,26)27)7-12(15(14)22-19)13-9-23(3)17(24)16-11(13)5-6-20-16/h5-9,20,22H,1-4H3,(H,21,25)
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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463841
PNG
(2-isopropyl-N,N,4-trimethyl- 8-(6-methyl-7-oxo-6,7...)
Show SMILES CC(C)C1Oc2c(cc(c(C)c2N(C)C1=O)S(=O)(=O)N(C)C)-c1cn(C)c(=O)c2[nH]ccc12
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391587
PNG
(2,2,4-trimethyl-8-(6-methyl-7- oxo-6,7-dihydro-1H-...)
Show SMILES CN1C(=O)C(C)(C)Oc2c1cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)S(C)(=O)=O
Show InChI InChI=1S/C20H21N3O5S/c1-20(2)19(25)23(4)15-9-11(29(5,26)27)8-13(17(15)28-20)14-10-22(3)18(24)16-12(14)6-7-21-16/h6-10,21H,1-5H3
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391589
PNG
(6-(isopropylsulfonyl)-2,2,4- trimethyl-8-(6-methyl...)
Show SMILES CC(C)S(=O)(=O)c1cc2N(C)C(=O)C(C)(C)Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C22H25N3O5S/c1-12(2)31(28,29)13-9-15(16-11-24(5)20(26)18-14(16)7-8-23-18)19-17(10-13)25(6)21(27)22(3,4)30-19/h7-12,23H,1-6H3
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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391590
PNG
(6-(ethylsulfonyl)-2,2- dimethyl-8-(6-methyl-7-oxo-...)
Show SMILES CCS(=O)(=O)c1cc2NC(=O)C(C)(C)Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C20H21N3O5S/c1-5-29(26,27)11-8-13(17-15(9-11)22-19(25)20(2,3)28-17)14-10-23(4)18(24)16-12(14)6-7-21-16/h6-10,21H,5H2,1-4H3,(H,22,25)
PDB

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Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391592
PNG
(6-acetyl-2,2-dimethyl-8-(6- methyl-7-oxo-6,7-dihyd...)
Show SMILES CC(=O)c1cc2NC(=O)C(C)(C)Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C20H19N3O4/c1-10(24)11-7-13(17-15(8-11)22-19(26)20(2,3)27-17)14-9-23(4)18(25)16-12(14)5-6-21-16/h5-9,21H,1-4H3,(H,22,26)
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Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391593
PNG
(6-(1-hydroxyethyl)-2,2- dimethyl-8-(6-methyl-7-oxo...)
Show SMILES CC(O)c1cc2NC(=O)C(C)(C)Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391512
PNG
(US10472358, Example 10 | US10781209, Example 10 | ...)
Show SMILES COc1cc2N(C)C(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391517
PNG
(2-isopropyl-6-methoxy-8-(6- methyl-7-oxo-6,7-dihyd...)
Show SMILES COc1cc2N(Cc3ccncc3)C(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391517
PNG
(2-isopropyl-6-methoxy-8-(6- methyl-7-oxo-6,7-dihyd...)
Show SMILES COc1cc2N(Cc3ccncc3)C(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391523
PNG
(US10472358, Example 21 | US10781209, Example 21 | ...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)[N+]([O-])=O
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463784
PNG
(6-methoxy-8-(6-methyl-7- oxo-6,7-dihydro-1H- pyrro...)
Show SMILES COc1cc2N(C)CC(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)c1ccccc1
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391530
PNG
(US10472358, Example 26 | US10781209, Example 26 | ...)
Show SMILES COc1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ncc12)C(C)C
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391538
PNG
(2-isopropyl-N,N-dimethyl-8- (6-methyl-7-oxo-6,7-di...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)C(=O)N(C)C
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391543
PNG
(US10472358, Example 37 | US10781209, Example 37 | ...)
Show SMILES COCc1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391543
PNG
(US10472358, Example 37 | US10781209, Example 37 | ...)
Show SMILES COCc1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391547
PNG
(2-isopropyl-8-(6-methyl-7- oxo-6,7-dihydro-1H- pyr...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)C(N)=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391573
PNG
((3R)-3-isopropyl-5-(6-methyl-7- oxo-6,7-dihydro-1H...)
Show SMILES CC(C)[C@H]1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)S(C)(=O)=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391555
PNG
(2,2-dimethyl-8-(6-methyl-7- | US10781209, Example ...)
Show SMILES Cn1cc(-c2cc(cc3NC(=O)C(C)(C)Oc23)S(C)(=O)=O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C19H19N3O5S/c1-19(2)18(24)21-14-8-10(28(4,25)26)7-12(16(14)27-19)13-9-22(3)17(23)15-11(13)5-6-20-15/h5-9,20H,1-4H3,(H,21,24)
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391572
PNG
((3S)-3-isopropyl-5-(6-methyl-7- oxo-6,7-dihydro-1H...)
Show SMILES CC(C)[C@@H]1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)S(C)(=O)=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391562
PNG
(US10472358, Example 50 | US10781209, Example 50 | ...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)C(C)O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391563
PNG
(US10472358, Example 51 | US10781209, Example 51 | ...)
Show SMILES CCS(=O)(=O)c1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391569
PNG
(US10472358, Example 57 | US10781209, Example 57 | ...)
Show SMILES Cn1cc(-c2cc(cc3NC(=O)C4(CC4)Oc23)S(C)(=O)=O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C19H17N3O5S/c1-22-9-13(11-3-6-20-15(11)17(22)23)12-7-10(28(2,25)26)8-14-16(12)27-19(4-5-19)18(24)21-14/h3,6-9,20H,4-5H2,1-2H3,(H,21,24)
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391576
PNG
(US10472358, Example 64 | US10781209, Example 64 | ...)
Show SMILES Cn1cc(-c2cc(cc3NC(=O)C4(CCCCC4)Nc23)S(C)(=O)=O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C22H24N4O4S/c1-26-12-16(14-6-9-23-19(14)20(26)27)15-10-13(31(2,29)30)11-17-18(15)25-22(21(28)24-17)7-4-3-5-8-22/h6,9-12,23,25H,3-5,7-8H2,1-2H3,(H,24,28)
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391576
PNG
(US10472358, Example 64 | US10781209, Example 64 | ...)
Show SMILES Cn1cc(-c2cc(cc3NC(=O)C4(CCCCC4)Nc23)S(C)(=O)=O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C22H24N4O4S/c1-26-12-16(14-6-9-23-19(14)20(26)27)15-10-13(31(2,29)30)11-17-18(15)25-22(21(28)24-17)7-4-3-5-8-22/h6,9-12,23,25H,3-5,7-8H2,1-2H3,(H,24,28)
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463835
PNG
(8-(6-methyl-7-oxo-6,7-dihydro-1H- pyrazolo[3,4-c]p...)
Show SMILES CN1C(=O)C2(CCC2)Nc2c1cc(cc2-c1cn(C)c(=O)c2[nH]ncc12)S(C)(=O)=O
Show InChI InChI=1S/C20H21N5O4S/c1-24-10-14(13-9-21-23-17(13)18(24)26)12-7-11(30(3,28)29)8-15-16(12)22-20(5-4-6-20)19(27)25(15)2/h7-10,22H,4-6H2,1-3H3,(H,21,23)
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391595
PNG
(6-(1-hydroxyethyl)-2,2,4- trimethyl-8-(6-methyl-7-...)
Show SMILES CC(O)c1cc2N(C)C(=O)C(C)(C)Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391596
PNG
(US10781209, Example 83A | US9957268, Example 83A)
Show SMILES C[C@H](O)c1cc2N(C)C(=O)C(C)(C)Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391519
PNG
(US10472358, Example 17 | US10781209, Example 17 | ...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)C#N
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463784
PNG
(6-methoxy-8-(6-methyl-7- oxo-6,7-dihydro-1H- pyrro...)
Show SMILES COc1cc2N(C)CC(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)c1ccccc1
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391531
PNG
(US10472358, Example 27 | US10781209, Example 27 | ...)
Show SMILES COc1cc2NC(=O)C(C)(C)Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C19H19N3O4/c1-19(2)18(24)21-14-8-10(25-4)7-12(16(14)26-19)13-9-22(3)17(23)15-11(13)5-6-20-15/h5-9,20H,1-4H3,(H,21,24)
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391533
PNG
(US10472358, Example 29 | US10781209, Example 29 | ...)
Show SMILES COc1cc2NC(=O)C(C)(C)Oc2c(c1)-c1cn(C)c(=O)c2[nH]ncc12
Show InChI InChI=1S/C18H18N4O4/c1-18(2)17(24)20-13-6-9(25-4)5-10(15(13)26-18)12-8-22(3)16(23)14-11(12)7-19-21-14/h5-8H,1-4H3,(H,19,21)(H,20,24)
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463798
PNG
(US10781209, Example 35A)
Show SMILES COc1cc2NC(=O)[C@@H](Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C1CCCC1
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391548
PNG
(US10472358, Example 42B | US10781209, Example 42B ...)
Show SMILES COc1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ncc12)C1CCCC1
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391548
PNG
(US10472358, Example 42B | US10781209, Example 42B ...)
Show SMILES COc1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ncc12)C1CCCC1
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391556
PNG
(8-(6-methyl-7-oxo-6,7- dihydro-1H-pyrrolo[2,3- c]p...)
Show SMILES Cn1cc(-c2cc(cc3NC(=O)C(Oc23)c2ccccc2)S(C)(=O)=O)c2cc[nH]c2c1=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391562
PNG
(US10472358, Example 50 | US10781209, Example 50 | ...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)C(C)O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463823
PNG
(4-(cyclopropylmethyl)-2- isopropyl-8-(6-methyl-7-o...)
Show SMILES CC(C)C1Oc2c(cc(cc2-c2cn(C)c(=O)c3[nH]ccc23)S(C)(=O)=O)N(CC2CC2)C1=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM419989
PNG
(4-ethyl-2-isopropyl-8-(6- methyl-7-oxo-6,7-dihydro...)
Show SMILES CCN1C(=O)C(Oc2c1cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)S(C)(=O)=O)C(C)C
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM419990
PNG
(6-(ethylsulfonyl)-2-isopropyl- 4-methyl-8-(6-methy...)
Show SMILES CCS(=O)(=O)c1cc2N(C)C(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391570
PNG
(US10472358, Example 58 | US10781209, Example 58 | ...)
Show SMILES Cn1cc(-c2cc(cc3NC(=O)C(C)(C)Nc23)S(C)(=O)=O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C19H20N4O4S/c1-19(2)18(25)21-14-8-10(28(4,26)27)7-12(15(14)22-19)13-9-23(3)17(24)16-11(13)5-6-20-16/h5-9,20,22H,1-4H3,(H,21,25)
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391576
PNG
(US10472358, Example 64 | US10781209, Example 64 | ...)
Show SMILES Cn1cc(-c2cc(cc3NC(=O)C4(CCCCC4)Nc23)S(C)(=O)=O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C22H24N4O4S/c1-26-12-16(14-6-9-23-19(14)20(26)27)15-10-13(31(2,29)30)11-17-18(15)25-22(21(28)24-17)7-4-3-5-8-22/h6,9-12,23,25H,3-5,7-8H2,1-2H3,(H,24,28)
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM419996
PNG
((3R)-3-isopropyl-5-(6-methyl-7- oxo-6,7-dihydro-1H...)
Show SMILES CC(C)[C@H]1Nc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)S(C)(=O)=O
Show InChI InChI=1S/C20H22N4O4S/c1-10(2)16-19(25)22-15-8-11(29(4,27)28)7-13(17(15)23-16)14-9-24(3)20(26)18-12(14)5-6-21-18/h5-10,16,21,23H,1-4H3,(H,22,25)/t16-/m1/s1
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM419994
PNG
(8'-(6-methyl-7-oxo-6,7-dihydro- 1H-pyrrolo[2,3-c]p...)
Show SMILES Cn1cc(-c2cc(cc3NC(=O)C4(CCCC4)Nc23)S(C)(=O)=O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C21H22N4O4S/c1-25-11-15(13-5-8-22-18(13)19(25)26)14-9-12(30(2,28)29)10-16-17(14)24-21(20(27)23-16)6-3-4-7-21/h5,8-11,22,24H,3-4,6-7H2,1-2H3,(H,23,27)
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463836
PNG
(4-methyl-8-(6-methyl-7-oxo-6,7-dihydro- 1H-pyrazol...)
Show SMILES Cn1cc(-c2cc(cc3NC(=O)C4(CCC4)Nc23)S(C)(=O)=O)c2cn[nH]c2c1=O
Show InChI InChI=1S/C19H19N5O4S/c1-24-9-13(12-8-20-23-16(12)17(24)25)11-6-10(29(2,27)28)7-14-15(11)22-19(4-3-5-19)18(26)21-14/h6-9,22H,3-5H2,1-2H3,(H,20,23)(H,21,26)
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391581
PNG
(N,N,2,2,4-pentamethyl-8-(6- methyl-7-oxo-6,7-dihyd...)
Show SMILES CN(C)S(=O)(=O)c1cc2N(C)C(=O)C(C)(C)Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C21H24N4O5S/c1-21(2)20(27)25(6)16-10-12(31(28,29)23(3)4)9-14(18(16)30-21)15-11-24(5)19(26)17-13(15)7-8-22-17/h7-11,22H,1-6H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463843
PNG
(2,2,4-trimethyl-8-(6-methyl-7- oxo-6,7-dihydro-1H-...)
Show SMILES CC(C)C1Oc2c(cc(c(C)c2N(C)C1=O)S(=O)(=O)N1CCCCC1)-c1cn(C)c(=O)c2[nH]ccc12
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391590
PNG
(6-(ethylsulfonyl)-2,2- dimethyl-8-(6-methyl-7-oxo-...)
Show SMILES CCS(=O)(=O)c1cc2NC(=O)C(C)(C)Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C20H21N3O5S/c1-5-29(26,27)11-8-13(17-15(9-11)22-19(25)20(2,3)28-17)14-10-23(4)18(24)16-12(14)6-7-21-16/h6-10,21H,5H2,1-4H3,(H,22,25)
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391594
PNG
(6-acetyl-2,2,4-trimethyl-8-(6- methyl-7-oxo-6,7-di...)
Show SMILES CN1C(=O)C(C)(C)Oc2c1cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)C(C)=O
Show InChI InChI=1S/C21H21N3O4/c1-11(25)12-8-14(15-10-23(4)19(26)17-13(15)6-7-22-17)18-16(9-12)24(5)20(27)21(2,3)28-18/h6-10,22H,1-5H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391597
PNG
(US10781209, Example 83B | US9957268, Example 83B)
Show SMILES C[C@@H](O)c1cc2N(C)C(=O)C(C)(C)Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391501
PNG
(US10472358, Example 1 | US10781209, Example 1 | US...)
Show SMILES Cn1cc(-c2cccc3NC(=O)C(Oc23)c2ccccc2)c2cc[nH]c2c1=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391509
PNG
(US10472358, Example 9B | US10781209, Example 9 | U...)
Show SMILES COc1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391515
PNG
(2-[2-isopropyl-6-methoxy-8- (6-methyl-7-oxo-6,7-di...)
Show SMILES COc1cc2N(CC(N)=O)C(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391521
PNG
(US10472358, Example 19 | US10781209, Example 19 | ...)
Show SMILES CC(C)C1Oc2c(cc(cc2-c2cn(C)c(=O)c3[nH]ccc23)C(N)=O)N(C)C1=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391522
PNG
(US10472358, Example 20 | US10781209, Example 20 | ...)
Show SMILES CNC(=O)c1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463785
PNG
(US10781209, Example 24A)
Show SMILES COc1cc2N(C)C[C@@H](Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)c1ccccc1
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463785
PNG
(US10781209, Example 24A)
Show SMILES COc1cc2N(C)C[C@@H](Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)c1ccccc1
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391531
PNG
(US10472358, Example 27 | US10781209, Example 27 | ...)
Show SMILES COc1cc2NC(=O)C(C)(C)Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C19H19N3O4/c1-19(2)18(24)21-14-8-10(25-4)7-12(16(14)26-19)13-9-22(3)17(23)15-11(13)5-6-20-15/h5-9,20H,1-4H3,(H,21,24)
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391533
PNG
(US10472358, Example 29 | US10781209, Example 29 | ...)
Show SMILES COc1cc2NC(=O)C(C)(C)Oc2c(c1)-c1cn(C)c(=O)c2[nH]ncc12
Show InChI InChI=1S/C18H18N4O4/c1-18(2)17(24)20-13-6-9(25-4)5-10(15(13)26-18)12-8-22(3)16(23)14-11(12)7-19-21-14/h5-8H,1-4H3,(H,19,21)(H,20,24)
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391572
PNG
((3S)-3-isopropyl-5-(6-methyl-7- oxo-6,7-dihydro-1H...)
Show SMILES CC(C)[C@@H]1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)S(C)(=O)=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391573
PNG
((3R)-3-isopropyl-5-(6-methyl-7- oxo-6,7-dihydro-1H...)
Show SMILES CC(C)[C@H]1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)S(C)(=O)=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391572
PNG
((3S)-3-isopropyl-5-(6-methyl-7- oxo-6,7-dihydro-1H...)
Show SMILES CC(C)[C@@H]1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)S(C)(=O)=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463823
PNG
(4-(cyclopropylmethyl)-2- isopropyl-8-(6-methyl-7-o...)
Show SMILES CC(C)C1Oc2c(cc(cc2-c2cn(C)c(=O)c3[nH]ccc23)S(C)(=O)=O)N(CC2CC2)C1=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391579
PNG
(US10472358, Example 67 | US10781209, Example 67 | ...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)S(=O)(=O)N(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463844
PNG
(N-isopropyl-2,2-dimethyl-8- (6-methyl-7-oxo-6,7-di...)
Show SMILES CC(C)NS(=O)(=O)c1cc2N(C)C(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391591
PNG
(6-(isopropylsulfonyl)-2,2- dimethyl-8-(6-methyl-7-...)
Show SMILES CC(C)S(=O)(=O)c1cc2NC(=O)C(C)(C)Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C21H23N3O5S/c1-11(2)30(27,28)12-8-14(18-16(9-12)23-20(26)21(3,4)29-18)15-10-24(5)19(25)17-13(15)6-7-22-17/h6-11,22H,1-5H3,(H,23,26)
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391594
PNG
(6-acetyl-2,2,4-trimethyl-8-(6- methyl-7-oxo-6,7-di...)
Show SMILES CN1C(=O)C(C)(C)Oc2c1cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)C(C)=O
Show InChI InChI=1S/C21H21N3O4/c1-11(25)12-8-14(15-10-23(4)19(26)17-13(15)6-7-22-17)18-16(9-12)24(5)20(27)21(2,3)28-18/h6-10,22H,1-5H3
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391598
PNG
(US10472358, Example 84 | US10781209, Example 84 | ...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ncc12)S(C)(=O)=O
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463769
PNG
(US10781209, Example 9B)
Show SMILES COc1cc2NC(=O)[C@H](Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM419932
PNG
(2,4-diisopropyl-6-methoxy-8- | US10472358, Example...)
Show SMILES COc1cc2N(C(C)C)C(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391524
PNG
(US10472358, Example 22 | US10781209, Example 22 | ...)
Show SMILES COc1cc2N(C)CC(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463786
PNG
(US10781209, Example 24B)
Show SMILES COc1cc2N(C)C[C@H](Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)c1ccccc1
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391529
PNG
(US10472358, Example 25 | US10781209, Example 25 | ...)
Show SMILES COc1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)c1ccc(F)cc1Cl
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391529
PNG
(US10472358, Example 25 | US10781209, Example 25 | ...)
Show SMILES COc1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)c1ccc(F)cc1Cl
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391534
PNG
(US10472358, Example 30 | US10781209, Example 30 | ...)
Show SMILES Cn1cc(-c2cccc3NC(=O)C4(CC4)Oc23)c2cc[nH]c2c1=O
Show InChI InChI=1S/C18H15N3O3/c1-21-9-12(10-5-8-19-14(10)16(21)22)11-3-2-4-13-15(11)24-18(6-7-18)17(23)20-13/h2-5,8-9,19H,6-7H2,1H3,(H,20,23)
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391536
PNG
(US10472358, Example 32 | US10781209, Example 32 | ...)
Show SMILES Cn1cc(-c2cccc3NC(=O)C(C)(C)Nc23)c2cc[nH]c2c1=O
Show InChI InChI=1S/C18H18N4O2/c1-18(2)17(24)20-13-6-4-5-10(14(13)21-18)12-9-22(3)16(23)15-11(12)7-8-19-15/h4-9,19,21H,1-3H3,(H,20,24)
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391537
PNG
(2-isopropyl-8-(6-methyl-7- oxo-6,7-dihydro-1H- pyr...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)C(=O)N1CCOCC1
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391542
PNG
(US10472358, Example 36 | US10781209, Example 36 | ...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(CO)cc2-c1cn(C)c(=O)c2[nH]ccc12
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391546
PNG
(N-{[2-isopropyl-8-(6-methyl- 7-oxo-6,7-dihydro-1H-...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(CNC(C)=O)cc2-c1cn(C)c(=O)c2[nH]ccc12
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391548
PNG
(US10472358, Example 42B | US10781209, Example 42B ...)
Show SMILES COc1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ncc12)C1CCCC1
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391552
PNG
(US10472358, Example 44B | US10781209, Example 47 |...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)S(C)(=O)=O
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391556
PNG
(8-(6-methyl-7-oxo-6,7- dihydro-1H-pyrrolo[2,3- c]p...)
Show SMILES Cn1cc(-c2cc(cc3NC(=O)C(Oc23)c2ccccc2)S(C)(=O)=O)c2cc[nH]c2c1=O
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391552
PNG
(US10472358, Example 44B | US10781209, Example 47 |...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)S(C)(=O)=O
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM419982
PNG
(2-(2-hydroxyethyl)-8-(6- methyl-7-oxo-6,7-dihydro-...)
Show SMILES Cn1cc(-c2cc(cc3NC(=O)C(CCO)Oc23)S(C)(=O)=O)c2cc[nH]c2c1=O
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391576
PNG
(US10472358, Example 64 | US10781209, Example 64 | ...)
Show SMILES Cn1cc(-c2cc(cc3NC(=O)C4(CCCCC4)Nc23)S(C)(=O)=O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C22H24N4O4S/c1-26-12-16(14-6-9-23-19(14)20(26)27)15-10-13(31(2,29)30)11-17-18(15)25-22(21(28)24-17)7-4-3-5-8-22/h6,9-12,23,25H,3-5,7-8H2,1-2H3,(H,24,28)
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391579
PNG
(US10472358, Example 67 | US10781209, Example 67 | ...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)S(=O)(=O)N(C)C
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463842
PNG
(2,2-dimethyl-8-(6-methyl-7- oxo-6,7-dihydro-1H- py...)
Show SMILES CC(C)C1Oc2c(cc(cc2-c2cn(C)c(=O)c3[nH]ccc23)S(=O)(=O)N2CCCCC2)N(C)C1=O
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463844
PNG
(N-isopropyl-2,2-dimethyl-8- (6-methyl-7-oxo-6,7-di...)
Show SMILES CC(C)NS(=O)(=O)c1cc2N(C)C(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391588
PNG
(6-(ethylsulfonyl)-2,2,4- trimethyl-8-(6-methyl-7-o...)
Show SMILES CCS(=O)(=O)c1cc2N(C)C(=O)C(C)(C)Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C21H23N3O5S/c1-6-30(27,28)12-9-14(15-11-23(4)19(25)17-13(15)7-8-22-17)18-16(10-12)24(5)20(26)21(2,3)29-18/h7-11,22H,6H2,1-5H3
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391598
PNG
(US10472358, Example 84 | US10781209, Example 84 | ...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ncc12)S(C)(=O)=O
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391502
PNG
(2-isopropyl-8-(6-methyl-7- | US10472358, Example 2...)
Show SMILES CC(C)C1Oc2c(NC1=O)cccc2-c1cn(C)c(=O)c2[nH]ccc12
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391503
PNG
(2-methyl-8-(6-methyl-7-oxo- | US10472358, Example ...)
Show SMILES CC1Oc2c(NC1=O)cccc2-c1cn(C)c(=O)c2[nH]ccc12
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391504
PNG
(2-ethyl-8-(6-methyl-7-oxo- | US10472358, Example 4...)
Show SMILES CCC1Oc2c(NC1=O)cccc2-c1cn(C)c(=O)c2[nH]ccc12
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391506
PNG
(US10472358, Example 6 | US10781209, Example 6 | US...)
Show SMILES Cn1cc(-c2cccc3NC(=O)C(Oc23)C2CC2)c2cc[nH]c2c1=O
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391507
PNG
(US10472358, Example 7 | US10781209, Example 7 | US...)
Show SMILES Cn1cc(-c2cccc3NC(=O)C(Oc23)C2CCOCC2)c2cc[nH]c2c1=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391509
PNG
(US10472358, Example 9B | US10781209, Example 9 | U...)
Show SMILES COc1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463769
PNG
(US10781209, Example 9B)
Show SMILES COc1cc2NC(=O)[C@H](Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391512
PNG
(US10472358, Example 10 | US10781209, Example 10 | ...)
Show SMILES COc1cc2N(C)C(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463783
PNG
(2-cyclopropyl-6-methoxy- 8-(6-methyl-7-oxo-6,7- di...)
Show SMILES COc1cc2N(C)CC(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C1CC1
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463786
PNG
(US10781209, Example 24B)
Show SMILES COc1cc2N(C)C[C@H](Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)c1ccccc1
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391530
PNG
(US10472358, Example 26 | US10781209, Example 26 | ...)
Show SMILES COc1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ncc12)C(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391535
PNG
(US10472358, Example 31 | US10781209, Example 31 | ...)
Show SMILES Cn1cc(-c2cccc3NC(=O)C(C)(C)Oc23)c2cc[nH]c2c1=O
Show InChI InChI=1S/C18H17N3O3/c1-18(2)17(23)20-13-6-4-5-11(15(13)24-18)12-9-21(3)16(22)14-10(12)7-8-19-14/h4-9,19H,1-3H3,(H,20,23)
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391537
PNG
(2-isopropyl-8-(6-methyl-7- oxo-6,7-dihydro-1H- pyr...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)C(=O)N1CCOCC1
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391539
PNG
(US10472358, Example 35B | US10781209, Example 35 |...)
Show SMILES COc1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C1CCCC1
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391544
PNG
(US10472358, Example 38 | US10781209, Example 38 | ...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(CN)cc2-c1cn(C)c(=O)c2[nH]ccc12
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391545
PNG
(US10472358, Example 39 | US10781209, Example 39 | ...)
Show SMILES CCS(=O)(=O)NCc1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391547
PNG
(2-isopropyl-8-(6-methyl-7- oxo-6,7-dihydro-1H- pyr...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)C(N)=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391551
PNG
(US10472358, Example 43 | US10781209, Example 43 | ...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)-c1ccco1
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391552
PNG
(US10472358, Example 44B | US10781209, Example 47 |...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)S(C)(=O)=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM419995
PNG
((3S)-3-isopropyl-5-(6-methyl-7- oxo-6,7-dihydro-1H...)
Show SMILES CC(C)[C@@H]1Nc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)S(C)(=O)=O
Show InChI InChI=1S/C20H22N4O4S/c1-10(2)16-19(25)22-15-8-11(29(4,27)28)7-13(17(15)23-16)14-9-24(3)20(26)18-12(14)5-6-21-18/h5-10,16,21,23H,1-4H3,(H,22,25)/t16-/m0/s1
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391575
PNG
(US10472358, Example 63 | US10781209, Example 63 | ...)
Show SMILES CN1C(=O)C2(CC2)Oc2c1cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)S(C)(=O)=O
Show InChI InChI=1S/C20H19N3O5S/c1-22-10-14(12-4-7-21-16(12)18(22)24)13-8-11(29(3,26)27)9-15-17(13)28-20(5-6-20)19(25)23(15)2/h4,7-10,21H,5-6H2,1-3H3
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463835
PNG
(8-(6-methyl-7-oxo-6,7-dihydro-1H- pyrazolo[3,4-c]p...)
Show SMILES CN1C(=O)C2(CCC2)Nc2c1cc(cc2-c1cn(C)c(=O)c2[nH]ncc12)S(C)(=O)=O
Show InChI InChI=1S/C20H21N5O4S/c1-24-10-14(13-9-21-23-17(13)18(24)26)12-7-11(30(3,28)29)8-15-16(12)22-20(5-4-6-20)19(27)25(15)2/h7-10,22H,4-6H2,1-3H3,(H,21,23)
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463841
PNG
(2-isopropyl-N,N,4-trimethyl- 8-(6-methyl-7-oxo-6,7...)
Show SMILES CC(C)C1Oc2c(cc(c(C)c2N(C)C1=O)S(=O)(=O)N(C)C)-c1cn(C)c(=O)c2[nH]ccc12
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391587
PNG
(2,2,4-trimethyl-8-(6-methyl-7- oxo-6,7-dihydro-1H-...)
Show SMILES CN1C(=O)C(C)(C)Oc2c1cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)S(C)(=O)=O
Show InChI InChI=1S/C20H21N3O5S/c1-20(2)19(25)23(4)15-9-11(29(5,26)27)8-13(17(15)28-20)14-10-22(3)18(24)16-12(14)6-7-21-16/h6-10,21H,1-5H3
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391591
PNG
(6-(isopropylsulfonyl)-2,2- dimethyl-8-(6-methyl-7-...)
Show SMILES CC(C)S(=O)(=O)c1cc2NC(=O)C(C)(C)Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C21H23N3O5S/c1-11(2)30(27,28)12-8-14(18-16(9-12)23-20(26)21(3,4)29-18)15-10-24(5)19(25)17-13(15)6-7-22-17/h6-11,22H,1-5H3,(H,23,26)
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391593
PNG
(6-(1-hydroxyethyl)-2,2- dimethyl-8-(6-methyl-7-oxo...)
Show SMILES CC(O)c1cc2NC(=O)C(C)(C)Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391597
PNG
(US10781209, Example 83B | US9957268, Example 83B)
Show SMILES C[C@@H](O)c1cc2N(C)C(=O)C(C)(C)Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391501
PNG
(US10472358, Example 1 | US10781209, Example 1 | US...)
Show SMILES Cn1cc(-c2cccc3NC(=O)C(Oc23)c2ccccc2)c2cc[nH]c2c1=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391505
PNG
(US10472358, Example 5 | US10781209, Example 5 | US...)
Show SMILES Cn1cc(-c2cccc3NC(=O)C(Oc23)c2ccccn2)c2cc[nH]c2c1=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391508
PNG
(US10472358, Example 8 | US10781209, Example 8 | US...)
Show SMILES CCC1Oc2c(cccc2-c2cn(C)c(=O)c3[nH]ccc23)N(C)C1=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463768
PNG
(US10781209, Example 9A)
Show SMILES COc1cc2NC(=O)[C@@H](Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463768
PNG
(US10781209, Example 9A)
Show SMILES COc1cc2NC(=O)[C@@H](Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391514
PNG
(US10472358, Example 12 | US10781209, Example 12 | ...)
Show SMILES CNC(=O)CN1C(=O)C(Oc2c1cc(OC)cc2-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391516
PNG
(2-isopropyl-6-methoxy-8-(6- methyl-7-oxo-6,7-dihyd...)
Show SMILES COc1cc2N(CC(=O)N3CCN(C)CC3)C(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391520
PNG
(US10472358, Example 18 | US10781209, Example 18 | ...)
Show SMILES CC(C)C1Oc2c(cc(cc2-c2cn(C)c(=O)c3[nH]ccc23)C#N)N(C)C1=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463783
PNG
(2-cyclopropyl-6-methoxy- 8-(6-methyl-7-oxo-6,7- di...)
Show SMILES COc1cc2N(C)CC(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C1CC1
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM419945
PNG
(US10472358, Example 28 | US10781209, Example 28)
Show SMILES CN\C=C(/C=N)c1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391534
PNG
(US10472358, Example 30 | US10781209, Example 30 | ...)
Show SMILES Cn1cc(-c2cccc3NC(=O)C4(CC4)Oc23)c2cc[nH]c2c1=O
Show InChI InChI=1S/C18H15N3O3/c1-21-9-12(10-5-8-19-14(10)16(21)22)11-3-2-4-13-15(11)24-18(6-7-18)17(23)20-13/h2-5,8-9,19H,6-7H2,1H3,(H,20,23)
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391535
PNG
(US10472358, Example 31 | US10781209, Example 31 | ...)
Show SMILES Cn1cc(-c2cccc3NC(=O)C(C)(C)Oc23)c2cc[nH]c2c1=O
Show InChI InChI=1S/C18H17N3O3/c1-18(2)17(23)20-13-6-4-5-11(15(13)24-18)12-9-21(3)16(22)14-10(12)7-8-19-14/h4-9,19H,1-3H3,(H,20,23)
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391538
PNG
(2-isopropyl-N,N-dimethyl-8- (6-methyl-7-oxo-6,7-di...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)C(=O)N(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391542
PNG
(US10472358, Example 36 | US10781209, Example 36 | ...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(CO)cc2-c1cn(C)c(=O)c2[nH]ccc12
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391546
PNG
(N-{[2-isopropyl-8-(6-methyl- 7-oxo-6,7-dihydro-1H-...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(CNC(C)=O)cc2-c1cn(C)c(=O)c2[nH]ccc12
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391548
PNG
(US10472358, Example 42B | US10781209, Example 42B ...)
Show SMILES COc1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ncc12)C1CCCC1
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391548
PNG
(US10472358, Example 42B | US10781209, Example 42B ...)
Show SMILES COc1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ncc12)C1CCCC1
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391552
PNG
(US10472358, Example 44B | US10781209, Example 47 |...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)S(C)(=O)=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463817
PNG
(US10781209, Example 47B)
Show SMILES CC(C)[C@H]1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)C(O)=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM419982
PNG
(2-(2-hydroxyethyl)-8-(6- methyl-7-oxo-6,7-dihydro-...)
Show SMILES Cn1cc(-c2cc(cc3NC(=O)C(CCO)Oc23)S(C)(=O)=O)c2cc[nH]c2c1=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463819
PNG
(6-acetyl-2-isopropyl-8-(6- methyl-7-oxo-6,7-dihydr...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)C(O)=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391563
PNG
(US10472358, Example 51 | US10781209, Example 51 | ...)
Show SMILES CCS(=O)(=O)c1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391564
PNG
(2-isopropyl-6- (isopropylsulfonyl)-8-(6- methyl-7-...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)S(=O)(=O)C(C)C
PDB

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US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM419995
PNG
((3S)-3-isopropyl-5-(6-methyl-7- oxo-6,7-dihydro-1H...)
Show SMILES CC(C)[C@@H]1Nc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)S(C)(=O)=O
Show InChI InChI=1S/C20H22N4O4S/c1-10(2)16-19(25)22-15-8-11(29(4,27)28)7-13(17(15)23-16)14-9-24(3)20(26)18-12(14)5-6-21-18/h5-10,16,21,23H,1-4H3,(H,22,25)/t16-/m0/s1
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391575
PNG
(US10472358, Example 63 | US10781209, Example 63 | ...)
Show SMILES CN1C(=O)C2(CC2)Oc2c1cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)S(C)(=O)=O
Show InChI InChI=1S/C20H19N3O5S/c1-22-10-14(12-4-7-21-16(12)18(22)24)13-8-11(29(3,26)27)9-15-17(13)28-20(5-6-20)19(25)23(15)2/h4,7-10,21H,5-6H2,1-3H3
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463836
PNG
(4-methyl-8-(6-methyl-7-oxo-6,7-dihydro- 1H-pyrazol...)
Show SMILES Cn1cc(-c2cc(cc3NC(=O)C4(CCC4)Nc23)S(C)(=O)=O)c2cn[nH]c2c1=O
Show InChI InChI=1S/C19H19N5O4S/c1-24-9-13(12-8-20-23-16(12)17(24)25)11-6-10(29(2,27)28)7-14-15(11)22-19(4-3-5-19)18(26)21-14/h6-9,22H,3-5H2,1-2H3,(H,20,23)(H,21,26)
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391580
PNG
(2-isopropyl-N-methyl-8-(6- methyl-7-oxo-6,7-dihydr...)
Show SMILES CNS(=O)(=O)c1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391580
PNG
(2-isopropyl-N-methyl-8-(6- methyl-7-oxo-6,7-dihydr...)
Show SMILES CNS(=O)(=O)c1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463839
PNG
(N,N,2,2,4-pentamethyl-8-(6- methyl-7-oxo-6,7-dihyd...)
Show SMILES CN(C)S(=O)(=O)c1cc(c2OC(C)(C)C(=O)N(C)c2c1C)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C22H26N4O5S/c1-12-16(32(29,30)24(4)5)10-14(19-18(12)26(7)21(28)22(2,3)31-19)15-11-25(6)20(27)17-13(15)8-9-23-17/h8-11,23H,1-7H3
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391592
PNG
(6-acetyl-2,2-dimethyl-8-(6- methyl-7-oxo-6,7-dihyd...)
Show SMILES CC(=O)c1cc2NC(=O)C(C)(C)Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C20H19N3O4/c1-10(24)11-7-13(17-15(8-11)22-19(26)20(2,3)27-17)14-9-23(4)18(25)16-12(14)5-6-21-16/h5-9,21H,1-4H3,(H,22,26)
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391596
PNG
(US10781209, Example 83A | US9957268, Example 83A)
Show SMILES C[C@H](O)c1cc2N(C)C(=O)C(C)(C)Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391506
PNG
(US10472358, Example 6 | US10781209, Example 6 | US...)
Show SMILES Cn1cc(-c2cccc3NC(=O)C(Oc23)C2CC2)c2cc[nH]c2c1=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391507
PNG
(US10472358, Example 7 | US10781209, Example 7 | US...)
Show SMILES Cn1cc(-c2cccc3NC(=O)C(Oc23)C2CCOCC2)c2cc[nH]c2c1=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463799
PNG
(US10781209, Example 35B)
Show SMILES COc1cc2NC(=O)[C@H](Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C1CCCC1
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463799
PNG
(US10781209, Example 35B)
Show SMILES COc1cc2NC(=O)[C@H](Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C1CCCC1
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391545
PNG
(US10472358, Example 39 | US10781209, Example 39 | ...)
Show SMILES CCS(=O)(=O)NCc1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463817
PNG
(US10781209, Example 47B)
Show SMILES CC(C)[C@H]1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)C(O)=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391564
PNG
(2-isopropyl-6- (isopropylsulfonyl)-8-(6- methyl-7-...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)S(=O)(=O)C(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391568
PNG
(2-isopropyl-6- (isopropylsulfonyl)-4-methyl- 8-(6-...)
Show SMILES CC(C)C1Oc2c(cc(cc2-c2cn(C)c(=O)c3[nH]ccc23)S(=O)(=O)C(C)C)N(C)C1=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391569
PNG
(US10472358, Example 57 | US10781209, Example 57 | ...)
Show SMILES Cn1cc(-c2cc(cc3NC(=O)C4(CC4)Oc23)S(C)(=O)=O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C19H17N3O5S/c1-22-9-13(11-3-6-20-15(11)17(22)23)12-7-10(28(2,25)26)8-14-16(12)27-19(4-5-19)18(24)21-14/h3,6-9,20H,4-5H2,1-2H3,(H,21,24)
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM419996
PNG
((3R)-3-isopropyl-5-(6-methyl-7- oxo-6,7-dihydro-1H...)
Show SMILES CC(C)[C@H]1Nc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)S(C)(=O)=O
Show InChI InChI=1S/C20H22N4O4S/c1-10(2)16-19(25)22-15-8-11(29(4,27)28)7-13(17(15)23-16)14-9-24(3)20(26)18-12(14)5-6-21-18/h5-10,16,21,23H,1-4H3,(H,22,25)/t16-/m1/s1
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM419994
PNG
(8'-(6-methyl-7-oxo-6,7-dihydro- 1H-pyrrolo[2,3-c]p...)
Show SMILES Cn1cc(-c2cc(cc3NC(=O)C4(CCCC4)Nc23)S(C)(=O)=O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C21H22N4O4S/c1-25-11-15(13-5-8-22-18(13)19(25)26)14-9-12(30(2,28)29)10-16-17(14)24-21(20(27)23-16)6-3-4-7-21/h5,8-11,22,24H,3-4,6-7H2,1-2H3,(H,23,27)
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463839
PNG
(N,N,2,2,4-pentamethyl-8-(6- methyl-7-oxo-6,7-dihyd...)
Show SMILES CN(C)S(=O)(=O)c1cc(c2OC(C)(C)C(=O)N(C)c2c1C)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C22H26N4O5S/c1-12-16(32(29,30)24(4)5)10-14(19-18(12)26(7)21(28)22(2,3)31-19)15-11-25(6)20(27)17-13(15)8-9-23-17/h8-11,23H,1-7H3
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391581
PNG
(N,N,2,2,4-pentamethyl-8-(6- methyl-7-oxo-6,7-dihyd...)
Show SMILES CN(C)S(=O)(=O)c1cc2N(C)C(=O)C(C)(C)Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C21H24N4O5S/c1-21(2)20(27)25(6)16-10-12(31(28,29)23(3)4)9-14(18(16)30-21)15-11-24(5)19(26)17-13(15)7-8-22-17/h7-11,22H,1-6H3
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463842
PNG
(2,2-dimethyl-8-(6-methyl-7- oxo-6,7-dihydro-1H- py...)
Show SMILES CC(C)C1Oc2c(cc(cc2-c2cn(C)c(=O)c3[nH]ccc23)S(=O)(=O)N2CCCCC2)N(C)C1=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM463843
PNG
(2,2,4-trimethyl-8-(6-methyl-7- oxo-6,7-dihydro-1H-...)
Show SMILES CC(C)C1Oc2c(cc(c(C)c2N(C)C1=O)S(=O)(=O)N1CCCCC1)-c1cn(C)c(=O)c2[nH]ccc12
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391588
PNG
(6-(ethylsulfonyl)-2,2,4- trimethyl-8-(6-methyl-7-o...)
Show SMILES CCS(=O)(=O)c1cc2N(C)C(=O)C(C)(C)Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C21H23N3O5S/c1-6-30(27,28)12-9-14(15-11-23(4)19(25)17-13(15)7-8-22-17)18-16(10-12)24(5)20(26)21(2,3)29-18/h7-11,22H,6H2,1-5H3
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391589
PNG
(6-(isopropylsulfonyl)-2,2,4- trimethyl-8-(6-methyl...)
Show SMILES CC(C)S(=O)(=O)c1cc2N(C)C(=O)C(C)(C)Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C22H25N3O5S/c1-12(2)31(28,29)13-9-15(16-11-24(5)20(26)18-14(16)7-8-23-18)19-17(10-13)25(6)21(27)22(3,4)30-19/h7-12,23H,1-6H3
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391595
PNG
(6-(1-hydroxyethyl)-2,2,4- trimethyl-8-(6-methyl-7-...)
Show SMILES CC(O)c1cc2N(C)C(=O)C(C)(C)Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391504
PNG
(2-ethyl-8-(6-methyl-7-oxo- | US10472358, Example 4...)
Show SMILES CCC1Oc2c(NC1=O)cccc2-c1cn(C)c(=O)c2[nH]ccc12
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391551
PNG
(US10472358, Example 43 | US10781209, Example 43 | ...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)-c1ccco1
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391521
PNG
(US10472358, Example 19 | US10781209, Example 19 | ...)
Show SMILES CC(C)C1Oc2c(cc(cc2-c2cn(C)c(=O)c3[nH]ccc23)C(N)=O)N(C)C1=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391515
PNG
(2-[2-isopropyl-6-methoxy-8- (6-methyl-7-oxo-6,7-di...)
Show SMILES COc1cc2N(CC(N)=O)C(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391516
PNG
(2-isopropyl-6-methoxy-8-(6- methyl-7-oxo-6,7-dihyd...)
Show SMILES COc1cc2N(CC(=O)N3CCN(C)CC3)C(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391544
PNG
(US10472358, Example 38 | US10781209, Example 38 | ...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(CN)cc2-c1cn(C)c(=O)c2[nH]ccc12
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391513
PNG
(US10472358, Example 11 | US10781209, Example 11 | ...)
Show SMILES COc1cc2N(CC(O)=O)C(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391514
PNG
(US10472358, Example 12 | US10781209, Example 12 | ...)
Show SMILES CNC(=O)CN1C(=O)C(Oc2c1cc(OC)cc2-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM419945
PNG
(US10472358, Example 28 | US10781209, Example 28)
Show SMILES CN\C=C(/C=N)c1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391519
PNG
(US10472358, Example 17 | US10781209, Example 17 | ...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)C#N
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391520
PNG
(US10472358, Example 18 | US10781209, Example 18 | ...)
Show SMILES CC(C)C1Oc2c(cc(cc2-c2cn(C)c(=O)c3[nH]ccc23)C#N)N(C)C1=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391505
PNG
(US10472358, Example 5 | US10781209, Example 5 | US...)
Show SMILES Cn1cc(-c2cccc3NC(=O)C(Oc23)c2ccccn2)c2cc[nH]c2c1=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391523
PNG
(US10472358, Example 21 | US10781209, Example 21 | ...)
Show SMILES CC(C)C1Oc2c(NC1=O)cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)[N+]([O-])=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391536
PNG
(US10472358, Example 32 | US10781209, Example 32 | ...)
Show SMILES Cn1cc(-c2cccc3NC(=O)C(C)(C)Nc23)c2cc[nH]c2c1=O
Show InChI InChI=1S/C18H18N4O2/c1-18(2)17(24)20-13-6-4-5-10(14(13)21-18)12-9-22(3)16(23)15-11(12)7-8-19-15/h4-9,19,21H,1-3H3,(H,20,24)
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391503
PNG
(2-methyl-8-(6-methyl-7-oxo- | US10472358, Example ...)
Show SMILES CC1Oc2c(NC1=O)cccc2-c1cn(C)c(=O)c2[nH]ccc12
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM419932
PNG
(2,4-diisopropyl-6-methoxy-8- | US10472358, Example...)
Show SMILES COc1cc2N(C(C)C)C(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391513
PNG
(US10472358, Example 11 | US10781209, Example 11 | ...)
Show SMILES COc1cc2N(CC(O)=O)C(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391524
PNG
(US10472358, Example 22 | US10781209, Example 22 | ...)
Show SMILES COc1cc2N(C)CC(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM391508
PNG
(US10472358, Example 8 | US10781209, Example 8 | US...)
Show SMILES CCC1Oc2c(cccc2-c2cn(C)c(=O)c3[nH]ccc23)N(C)C1=O
PDB

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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...


US Patent US10781209 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%