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Patent code US10787435

Compile Data Set for Download or QSAR
Found 57 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464011
PNG
(US10787435, Example 004 | WX004)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)-n1ccc2ccc(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C25H23N7O/c1-16(2)32-15-27-29-24(32)21-4-3-5-23(28-21)31-11-10-17-8-9-19(12-20(17)25(31)33)30-13-22(26-14-30)18-6-7-18/h3-5,8-16,18H,6-7H2,1-2H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464077
PNG
(US10787435, Example 055 | WX054)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)-n1cnc2cc(N(C)C)c(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C26H27N9O/c1-16(2)34-15-29-31-25(34)19-6-5-7-24(30-19)35-14-28-20-11-22(32(3)4)23(10-18(20)26(35)36)33-12-21(27-13-33)17-8-9-17/h5-7,10-17H,8-9H2,1-4H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464055
PNG
(US10787435, Example 033 | WX032)
Show SMILES COc1ccc(cn1)-c1cc2ncn(-c3cccc(n3)-c3nncn3C(C)C)c(=O)c2cc1-n1cnc(c1)C1CC1
Show InChI InChI=1S/C30H27N9O2/c1-18(2)38-17-34-36-29(38)23-5-4-6-27(35-23)39-16-33-24-11-21(20-9-10-28(41-3)31-13-20)26(12-22(24)30(39)40)37-14-25(32-15-37)19-7-8-19/h4-6,9-19H,7-8H2,1-3H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464045
PNG
(US10787435, Example 022 | WX022)
Show SMILES CCc1cc2ncn(-c3cccc(n3)-c3nncn3C(C)C)c(=O)c2cc1-n1cnc(c1)C1CC1
Show InChI InChI=1S/C26H26N8O/c1-4-17-10-21-19(11-23(17)32-12-22(27-13-32)18-8-9-18)26(35)34(14-28-21)24-7-5-6-20(30-24)25-31-29-15-33(25)16(2)3/h5-7,10-16,18H,4,8-9H2,1-3H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464056
PNG
(US10787435, Example 034 | WX033)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)-n1cnc2cc(-c3ccc(N)nc3)c(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C29H26N10O/c1-17(2)38-16-34-36-28(38)22-4-3-5-27(35-22)39-15-33-23-10-20(19-8-9-26(30)31-12-19)25(11-21(23)29(39)40)37-13-24(32-14-37)18-6-7-18/h3-5,8-18H,6-7H2,1-2H3,(H2,30,31)
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464047
PNG
(US10787435, Example 024 | WX024)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)-n1cnc2cc(-c3cccnc3)c(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C29H25N9O/c1-18(2)37-17-33-35-28(37)23-6-3-7-27(34-23)38-16-32-24-11-21(20-5-4-10-30-13-20)26(12-22(24)29(38)39)36-14-25(31-15-36)19-8-9-19/h3-7,10-19H,8-9H2,1-2H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464017
PNG
(US10787435, Example 007 | WX007)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)-n1cc(F)c2cc(C)c(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C26H24FN7O/c1-15(2)34-14-29-31-25(34)21-5-4-6-24(30-21)33-11-20(27)18-9-16(3)23(10-19(18)26(33)35)32-12-22(28-13-32)17-7-8-17/h4-6,9-15,17H,7-8H2,1-3H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM463999
PNG
(US10787435, Example 002 | WX002)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)N1CCc2cc(C)c(cc2C1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C26H27N7O/c1-16(2)33-15-28-30-25(33)21-5-4-6-24(29-21)32-10-9-19-11-17(3)23(12-20(19)26(32)34)31-13-22(27-14-31)18-7-8-18/h4-6,11-16,18H,7-10H2,1-3H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464062
PNG
(US10787435, Example 040 | WX039)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)-n1cnc2cc(OCCCS(C)(=O)=O)c(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C28H30N8O4S/c1-18(2)35-17-31-33-27(35)21-6-4-7-26(32-21)36-16-30-22-13-25(40-10-5-11-41(3,38)39)24(12-20(22)28(36)37)34-14-23(29-15-34)19-8-9-19/h4,6-7,12-19H,5,8-11H2,1-3H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464059
PNG
(US10787435, Example 038 | WX036)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)-n1cnc2cc(OCC(N)=O)c(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C26H25N9O3/c1-15(2)34-14-30-32-25(34)18-4-3-5-24(31-18)35-13-29-19-9-22(38-11-23(27)36)21(8-17(19)26(35)37)33-10-20(28-12-33)16-6-7-16/h3-5,8-10,12-16H,6-7,11H2,1-2H3,(H2,27,36)
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464049
PNG
(US10787435, Example 026 | WX026)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)N1CCc2cc(Cl)c(cc2C1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C25H24ClN7O/c1-15(2)33-14-28-30-24(33)20-4-3-5-23(29-20)32-9-8-17-10-19(26)22(11-18(17)25(32)34)31-12-21(27-13-31)16-6-7-16/h3-5,10-16H,6-9H2,1-2H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464048
PNG
(US10787435, Example 025 | WX025)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)-n1cnc2cc(-c3ccsc3)c(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C28H24N8OS/c1-17(2)35-16-31-33-27(35)22-4-3-5-26(32-22)36-15-30-23-10-20(19-8-9-38-13-19)25(11-21(23)28(36)37)34-12-24(29-14-34)18-6-7-18/h3-5,8-18H,6-7H2,1-2H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464074
PNG
(US10787435, Example 052 | WX051)
Show SMILES CC(C)c1ccc(cn1)-c1cc2c(cc1C)ncn(-c1cccc(n1)-c1nncn1C(C)C)c2=O
Show InChI InChI=1S/C27H27N7O/c1-16(2)22-10-9-19(13-28-22)20-12-21-24(11-18(20)5)29-14-34(27(21)35)25-8-6-7-23(31-25)26-32-30-15-33(26)17(3)4/h6-17H,1-5H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464044
PNG
(US10787435, Example 021 | US10787435, Example 030 ...)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)-n1cnc2cc(Cl)c(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C24H21ClN8O/c1-14(2)32-13-28-30-23(32)18-4-3-5-22(29-18)33-12-27-19-9-17(25)21(8-16(19)24(33)34)31-10-20(26-11-31)15-6-7-15/h3-5,8-15H,6-7H2,1-2H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464042
PNG
(US10787435, Example 019 | WX019)
Show SMILES Cc1cc2ncn(-c3cccc(n3)-c3nncn3CC(F)(F)F)c(=O)c2cc1-n1cnc(c1)C1CC1
Show InChI InChI=1S/C24H19F3N8O/c1-14-7-18-16(8-20(14)33-9-19(28-11-33)15-5-6-15)23(36)35(12-29-18)21-4-2-3-17(31-21)22-32-30-13-34(22)10-24(25,26)27/h2-4,7-9,11-13,15H,5-6,10H2,1H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM463987
PNG
(US10787435, Example 001 | WX001)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)N1CCc2ccc(cc2C1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C25H25N7O/c1-16(2)32-15-27-29-24(32)21-4-3-5-23(28-21)31-11-10-17-8-9-19(12-20(17)25(31)33)30-13-22(26-14-30)18-6-7-18/h3-5,8-9,12-16,18H,6-7,10-11H2,1-2H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464075
PNG
(US10787435, Example 053 | WX052)
Show SMILES CCc1cn(cn1)-c1cc2c(cc1C)ncn(-c1cccc(n1)-c1nncn1C(C)C)c2=O
Show InChI InChI=1S/C24H24N8O/c1-5-17-11-30(12-25-17)21-10-18-20(9-16(21)4)26-13-32(24(18)33)22-8-6-7-19(28-22)23-29-27-14-31(23)15(2)3/h6-15H,5H2,1-4H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464076
PNG
(US10787435, Example 054 | WX053)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)-n1cnc2cc(OCCCF)c(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C27H27FN8O2/c1-17(2)35-16-31-33-26(35)20-5-3-6-25(32-20)36-15-30-21-12-24(38-10-4-9-28)23(11-19(21)27(36)37)34-13-22(29-14-34)18-7-8-18/h3,5-6,11-18H,4,7-10H2,1-2H3
PDB

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n/an/a<50n/an/an/an/an/an/a



Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464078
PNG
(US10787435, Example 056 | WX055)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)-n1cnc2cc(N3CCOCC3)c(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C28H29N9O2/c1-18(2)36-17-31-33-27(36)21-4-3-5-26(32-21)37-16-30-22-13-25(34-8-10-39-11-9-34)24(12-20(22)28(37)38)35-14-23(29-15-35)19-6-7-19/h3-5,12-19H,6-11H2,1-2H3
PDB

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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464021
PNG
(US10787435, Example 009 | WX009)
Show SMILES Cc1cc2CCN(C(=O)c2cc1-n1cnc(c1)C1CC1)c1cccc(n1)-c1nnc2CCCCn12
Show InChI InChI=1S/C27H27N7O/c1-17-13-19-10-12-34(27(35)20(19)14-23(17)32-15-22(28-16-32)18-8-9-18)24-7-4-5-21(29-24)26-31-30-25-6-2-3-11-33(25)26/h4-5,7,13-16,18H,2-3,6,8-12H2,1H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464061
PNG
(US10787435, Example 039 | WX038)
Show SMILES CNC(=O)COc1cc2ncn(-c3cccc(n3)-c3nncn3C(C)C)c(=O)c2cc1-n1cnc(c1)C1CC1
Show InChI InChI=1S/C27H27N9O3/c1-16(2)35-15-31-33-26(35)19-5-4-6-24(32-19)36-14-30-20-10-23(39-12-25(37)28-3)22(9-18(20)27(36)38)34-11-21(29-13-34)17-7-8-17/h4-6,9-11,13-17H,7-8,12H2,1-3H3,(H,28,37)
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464069
PNG
(US10787435, Example 047 | WX046)
Show SMILES Cc1cc2ncn(-c3cccc(n3)-c3nncn3C(C)(C)C)c(=O)c2cc1-n1cnc(c1)C1CC1
Show InChI InChI=1S/C26H26N8O/c1-16-10-20-18(11-22(16)32-12-21(27-13-32)17-8-9-17)25(35)33(14-28-20)23-7-5-6-19(30-23)24-31-29-15-34(24)26(2,3)4/h5-7,10-15,17H,8-9H2,1-4H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464073
PNG
(US10787435, Example 051 | WX050)
Show SMILES Cc1cc2ncn(-c3cccc(n3)-c3nncn3C3CCCCC3)c(=O)c2cc1-n1cnc(c1)C1CC1
Show InChI InChI=1S/C28H28N8O/c1-18-12-23-21(13-25(18)34-14-24(29-15-34)19-10-11-19)28(37)36(16-30-23)26-9-5-8-22(32-26)27-33-31-17-35(27)20-6-3-2-4-7-20/h5,8-9,12-17,19-20H,2-4,6-7,10-11H2,1H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464080
PNG
(US10787435, Example 058 | WX057)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)-n1cnc2cc(OCC3COC3)c(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C28H28N8O3/c1-17(2)35-16-31-33-27(35)21-4-3-5-26(32-21)36-15-30-22-9-25(39-13-18-11-38-12-18)24(8-20(22)28(36)37)34-10-23(29-14-34)19-6-7-19/h3-5,8-10,14-19H,6-7,11-13H2,1-2H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464066
PNG
(US10787435, Example 044 | WX043)
Show SMILES Cc1cc2ncn(-c3cccc(n3)-c3nncn3C3CCCC3)c(=O)c2cc1-n1cnc(c1)C1CC1
Show InChI InChI=1S/C27H26N8O/c1-17-11-22-20(12-24(17)33-13-23(28-14-33)18-9-10-18)27(36)35(15-29-22)25-8-4-7-21(31-25)26-32-30-16-34(26)19-5-2-3-6-19/h4,7-8,11-16,18-19H,2-3,5-6,9-10H2,1H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464072
PNG
(US10787435, Example 050 | WX049)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)-n1cnc2cc(C)c(cc2c1=O)-n1cnc(c1)-c1ccccc1
Show InChI InChI=1S/C28H24N8O/c1-18(2)35-17-31-33-27(35)22-10-7-11-26(32-22)36-16-30-23-12-19(3)25(13-21(23)28(36)37)34-14-24(29-15-34)20-8-5-4-6-9-20/h4-18H,1-3H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464079
PNG
(US10787435, Example 057 | WX056)
Show SMILES CC(CO)n1cnnc1-c1cccc(n1)-n1cnc2cc(C)c(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C25H24N8O2/c1-15-8-20-18(9-22(15)31-10-21(26-12-31)17-6-7-17)25(35)33(13-27-20)23-5-3-4-19(29-23)24-30-28-14-32(24)16(2)11-34/h3-5,8-10,12-14,16-17,34H,6-7,11H2,1-2H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464016
PNG
(US10787435, Example 006 | WX006)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)-n1ccc2cc(C)c(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C26H25N7O/c1-16(2)33-15-28-30-25(33)21-5-4-6-24(29-21)32-10-9-19-11-17(3)23(12-20(19)26(32)34)31-13-22(27-14-31)18-7-8-18/h4-6,9-16,18H,7-8H2,1-3H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464019
PNG
(US10787435, Example 008 | WX008)
Show SMILES Cc1cc2CCN(C(=O)c2cc1-n1cnc(c1)C1CC1)c1cccc(n1)-c1nnc2CCCn12
Show InChI InChI=1S/C26H25N7O/c1-16-12-18-9-11-33(23-5-2-4-20(28-23)25-30-29-24-6-3-10-32(24)25)26(34)19(18)13-22(16)31-14-21(27-15-31)17-7-8-17/h2,4-5,12-15,17H,3,6-11H2,1H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464027
PNG
(US10787435, Example 011 | WX011)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)-n1cnc2cc(C)c(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C25H24N8O/c1-15(2)32-14-28-30-24(32)19-5-4-6-23(29-19)33-13-27-20-9-16(3)22(10-18(20)25(33)34)31-11-21(26-12-31)17-7-8-17/h4-6,9-15,17H,7-8H2,1-3H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464030
PNG
(US10787435, Example 013 | WX013)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)-n1cnc2ccc(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C24H22N8O/c1-15(2)31-14-27-29-23(31)20-4-3-5-22(28-20)32-13-26-19-9-8-17(10-18(19)24(32)33)30-11-21(25-12-30)16-6-7-16/h3-5,8-16H,6-7H2,1-2H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464040
PNG
(US10787435, Example 018 | WX018)
Show SMILES Cc1cc2ncn(-c3cccc(n3)-c3nncn3C3CC3)c(=O)c2cc1-n1cnc(c1)C1CC1
Show InChI InChI=1S/C25H22N8O/c1-15-9-20-18(10-22(15)31-11-21(26-12-31)16-5-6-16)25(34)33(13-27-20)23-4-2-3-19(29-23)24-30-28-14-32(24)17-7-8-17/h2-4,9-14,16-17H,5-8H2,1H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464044
PNG
(US10787435, Example 021 | US10787435, Example 030 ...)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)-n1cnc2cc(Cl)c(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C24H21ClN8O/c1-14(2)32-13-28-30-23(32)18-4-3-5-22(29-18)33-12-27-19-9-17(25)21(8-16(19)24(33)34)31-10-20(26-11-31)15-6-7-15/h3-5,8-15H,6-7H2,1-2H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464053
PNG
(US10787435, Example 031 | WX030)
Show SMILES COc1cc2ncn(-c3cccc(n3)-c3nncn3C(C)C)c(=O)c2cc1-n1cnc(c1)C1CC1
Show InChI InChI=1S/C25H24N8O2/c1-15(2)32-14-28-30-24(32)18-5-4-6-23(29-18)33-13-27-19-10-22(35-3)21(9-17(19)25(33)34)31-11-20(26-12-31)16-7-8-16/h4-6,9-16H,7-8H2,1-3H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464060
PNG
(US10787435, Example 037 | WX037)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)-n1cnc2cc(O)c(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C24H22N8O2/c1-14(2)31-13-27-29-23(31)17-4-3-5-22(28-17)32-12-26-18-9-21(33)20(8-16(18)24(32)34)30-10-19(25-11-30)15-6-7-15/h3-5,8-15,33H,6-7H2,1-2H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464063
PNG
(US10787435, Example 041 | WX040)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)-n1cnc2cc(OCCO)c(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C26H26N8O3/c1-16(2)33-15-29-31-25(33)19-4-3-5-24(30-19)34-14-28-20-11-23(37-9-8-35)22(10-18(20)26(34)36)32-12-21(27-13-32)17-6-7-17/h3-5,10-17,35H,6-9H2,1-2H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464067
PNG
(US10787435, Example 045 | WX044)
Show SMILES CCC(CC)n1cnnc1-c1cccc(n1)-n1cnc2cc(C)c(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C27H28N8O/c1-4-19(5-2)34-16-30-32-26(34)21-7-6-8-25(31-21)35-15-29-22-11-17(3)24(12-20(22)27(35)36)33-13-23(28-14-33)18-9-10-18/h6-8,11-16,18-19H,4-5,9-10H2,1-3H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464009
PNG
(US10787435, Example 003 | WX003)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)-n1cc(F)c2ccc(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C25H22FN7O/c1-15(2)33-14-28-30-24(33)21-4-3-5-23(29-21)32-11-20(26)18-9-8-17(10-19(18)25(32)34)31-12-22(27-13-31)16-6-7-16/h3-5,8-16H,6-7H2,1-2H3
PDB

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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464015
PNG
(US10787435, Example 005 | WX005)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)N1Cc2ccc(cc2C1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C24H23N7O/c1-15(2)31-14-26-28-23(31)20-4-3-5-22(27-20)30-11-17-8-9-18(10-19(17)24(30)32)29-12-21(25-13-29)16-6-7-16/h3-5,8-10,12-16H,6-7,11H2,1-2H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464046
PNG
(US10787435, Example 023 | WX023)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)-n1cnc2cc(-c3ccccc3)c(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C30H26N8O/c1-19(2)37-18-33-35-29(37)24-9-6-10-28(34-24)38-17-32-25-13-22(20-7-4-3-5-8-20)27(14-23(25)30(38)39)36-15-26(31-16-36)21-11-12-21/h3-10,13-19,21H,11-12H2,1-2H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464054
PNG
(US10787435, Example 032 | WX031)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)-n1cnc2cc(-c3ccc(C)nc3)c(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C30H27N9O/c1-18(2)38-17-34-36-29(38)24-5-4-6-28(35-24)39-16-33-25-11-22(21-8-7-19(3)31-13-21)27(12-23(25)30(39)40)37-14-26(32-15-37)20-9-10-20/h4-8,11-18,20H,9-10H2,1-3H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464057
PNG
(US10787435, Example 035 | WX034)
Show SMILES COCCOc1cc2ncn(-c3cccc(n3)-c3nncn3C(C)C)c(=O)c2cc1-n1cnc(c1)C1CC1
Show InChI InChI=1S/C27H28N8O3/c1-17(2)34-16-30-32-26(34)20-5-4-6-25(31-20)35-15-29-21-12-24(38-10-9-37-3)23(11-19(21)27(35)36)33-13-22(28-14-33)18-7-8-18/h4-6,11-18H,7-10H2,1-3H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464058
PNG
(US10787435, Example 036 | WX035)
Show SMILES CC(C)c1cc2ncn(-c3cccc(n3)-c3nncn3C(C)C)c(=O)c2cc1-n1cnc(c1)C1CC1
Show InChI InChI=1S/C27H28N8O/c1-16(2)19-10-22-20(11-24(19)33-12-23(28-13-33)18-8-9-18)27(36)35(14-29-22)25-7-5-6-21(31-25)26-32-30-15-34(26)17(3)4/h5-7,10-18H,8-9H2,1-4H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464068
PNG
(US10787435, Example 046 | WX045)
Show SMILES CC(C)n1cnnc1-c1nc(cs1)-n1cnc2cc(C)c(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C23H22N8OS/c1-13(2)30-12-26-28-21(30)22-27-20(9-33-22)31-11-25-17-6-14(3)19(7-16(17)23(31)32)29-8-18(24-10-29)15-4-5-15/h6-13,15H,4-5H2,1-3H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464024
PNG
(US10787435, Example 010 | WX010)
Show SMILES O=C1N(CCc2ccc(cc12)-n1cnc2CCCCc12)c1cccc(n1)-c1nnc2CCCCn12
Show InChI InChI=1S/C27H27N7O/c35-27-20-16-19(34-17-28-21-6-1-2-8-23(21)34)12-11-18(20)13-15-33(27)24-10-5-7-22(29-24)26-31-30-25-9-3-4-14-32(25)26/h5,7,10-12,16-17H,1-4,6,8-9,13-15H2
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464038
PNG
(US10787435, Example 017 | WX017)
Show SMILES Cc1cc2c(F)cn(-c3cccc(n3)-c3nnc4CCCCn34)c(=O)c2cc1-n1cnc(c1)C1CC1
Show InChI InChI=1S/C27H24FN7O/c1-16-11-18-19(12-23(16)33-14-22(29-15-33)17-8-9-17)27(36)35(13-20(18)28)24-7-4-5-21(30-24)26-32-31-25-6-2-3-10-34(25)26/h4-5,7,11-15,17H,2-3,6,8-10H2,1H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464071
PNG
(US10787435, Example 049 | WX048)
Show SMILES Cc1cc2ncn(-c3cccc(n3)-c3nncn3C3CCC(F)(F)CC3)c(=O)c2cc1-n1cnc(c1)C1CC1
Show InChI InChI=1S/C28H26F2N8O/c1-17-11-22-20(12-24(17)36-13-23(31-14-36)18-5-6-18)27(39)38(15-32-22)25-4-2-3-21(34-25)26-35-33-16-37(26)19-7-9-28(29,30)10-8-19/h2-4,11-16,18-19H,5-10H2,1H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464036
PNG
(US10787435, Example 016 | WX016)
Show SMILES CC(C)n1c(C)nnc1-c1cccc(n1)-n1cnc2cc(C)c(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C26H26N8O/c1-15(2)34-17(4)30-31-25(34)20-6-5-7-24(29-20)33-14-28-21-10-16(3)23(11-19(21)26(33)35)32-12-22(27-13-32)18-8-9-18/h5-7,10-15,18H,8-9H2,1-4H3
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n/an/a 525n/an/an/an/an/an/a



Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464031
PNG
(US10787435, Example 014 | WX014)
Show SMILES Cc1cc2ncn(-c3cccc(n3)-c3nnc4CCCCn34)c(=O)c2cc1-n1cnc(c1)C1CC1
Show InChI InChI=1S/C26H24N8O/c1-16-11-20-18(12-22(16)32-13-21(27-14-32)17-8-9-17)26(35)34(15-28-20)23-7-4-5-19(29-23)25-31-30-24-6-2-3-10-33(24)25/h4-5,7,11-15,17H,2-3,6,8-10H2,1H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464050
PNG
(US10787435, Example 028 | WX027)
Show SMILES Cc1cc2ncn(-c3cccc(n3)-c3nnc4CCCn34)c(=O)c2cc1-n1cnc(c1)C1CC1
Show InChI InChI=1S/C25H22N8O/c1-15-10-19-17(11-21(15)31-12-20(26-13-31)16-7-8-16)25(34)33(14-27-19)22-5-2-4-18(28-22)24-30-29-23-6-3-9-32(23)24/h2,4-5,10-14,16H,3,6-9H2,1H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464070
PNG
(US10787435, Example 048 | WX047)
Show SMILES Cc1cc2ncn(-c3cccc(n3)-c3nncn3C3CCOCC3)c(=O)c2cc1-n1cnc(c1)C1CC1
Show InChI InChI=1S/C27H26N8O2/c1-17-11-22-20(12-24(17)33-13-23(28-14-33)18-5-6-18)27(36)35(15-29-22)25-4-2-3-21(31-25)26-32-30-16-34(26)19-7-9-37-10-8-19/h2-4,11-16,18-19H,5-10H2,1H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464064
PNG
(US10787435, Example 042 | WX041)
Show SMILES CC(C)n1cnnc1-c1cc(cs1)-n1cnc2cc(C)c(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C24H23N7OS/c1-14(2)30-13-27-28-23(30)22-7-17(10-33-22)31-12-26-19-6-15(3)21(8-18(19)24(31)32)29-9-20(25-11-29)16-4-5-16/h6-14,16H,4-5H2,1-3H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464029
PNG
(US10787435, Example 012 | WX012)
Show SMILES Cc1nc(cn1-c1ccc2CCN(C(=O)c2c1)c1cccc(n1)-c1nnc2CCCCn12)C1CC1
Show InChI InChI=1S/C27H27N7O/c1-17-28-23(19-8-9-19)16-34(17)20-11-10-18-12-14-33(27(35)21(18)15-20)24-7-4-5-22(29-24)26-31-30-25-6-2-3-13-32(25)26/h4-5,7,10-11,15-16,19H,2-3,6,8-9,12-14H2,1H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464035
PNG
(US10787435, Example 015 | WX015)
Show SMILES Cc1nnc(-c2cccc(n2)-n2cnc3cc(C)c(cc3c2=O)-n2cnc(c2)C2CC2)n1C
Show InChI InChI=1S/C24H22N8O/c1-14-9-19-17(10-21(14)31-11-20(25-12-31)16-7-8-16)24(33)32(13-26-19)22-6-4-5-18(27-22)23-29-28-15(2)30(23)3/h4-6,9-13,16H,7-8H2,1-3H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464043
PNG
(US10787435, Example 020 | WX020)
Show SMILES Cc1nnc(o1)-c1cccc(n1)-n1cnc2cc(C)c(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C23H19N7O2/c1-13-8-18-16(9-20(13)29-10-19(24-11-29)15-6-7-15)23(31)30(12-25-18)21-5-3-4-17(26-21)22-28-27-14(2)32-22/h3-5,8-12,15H,6-7H2,1-2H3
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Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464065
PNG
(US10787435, Example 043 | WX042)
Show SMILES CC(C)n1cnnc1-c1cccc(c1)-n1cnc2cc(C)c(cc2c1=O)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C26H25N7O/c1-16(2)32-15-29-30-25(32)19-5-4-6-20(10-19)33-14-28-22-9-17(3)24(11-21(22)26(33)34)31-12-23(27-13-31)18-7-8-18/h4-6,9-16,18H,7-8H2,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM464051
PNG
(US10787435, Example 029 | WX028)
Show SMILES COc1nc2cc(C)c(cc2c(=O)n1-c1cccc(n1)-c1nncn1C(C)C)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C26H26N8O2/c1-15(2)33-14-28-31-24(33)19-6-5-7-23(29-19)34-25(35)18-11-22(16(3)10-20(18)30-26(34)36-4)32-12-21(27-13-32)17-8-9-17/h5-7,10-15,17H,8-9H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Fuijan Cosunter Pharmaceutical Co. Ltd.

US Patent


Assay Description
Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...


US Patent US10787435 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%