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Patent code US10792283

Compile Data Set for Download or QSAR
Found 7 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM464391
PNG
(US10792283, Compound 1)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1cc2ccc(F)cc2nc1-c1ccccc1
Show InChI InChI=1S/C22H18FN7/c1-12(27-21-17(11-24)20(25)29-22(26)30-21)16-9-14-7-8-15(23)10-18(14)28-19(16)13-5-3-2-4-6-13/h2-10,12H,1H3,(H5,25,26,27,29,30)/t12-/m0/s1
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US Patent
n/an/a 0.0430n/an/an/an/an/an/a



HANGZHOU ZHENGXIANG PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Enzymatic activity of the class I PI3K isoforms in the presence of the compounds of Table 1 above was measured using a time-resolved fluorescence res...


US Patent US10792283 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM464392
PNG
(US10792283, Compound 2)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1cc2ccc(F)cc2nc1-c1ccccn1
Show InChI InChI=1S/C21H17FN8/c1-11(27-20-15(10-23)19(24)29-21(25)30-20)14-8-12-5-6-13(22)9-17(12)28-18(14)16-4-2-3-7-26-16/h2-9,11H,1H3,(H5,24,25,27,29,30)/t11-/m0/s1
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US Patent
n/an/a 0.0860n/an/an/an/an/an/a



HANGZHOU ZHENGXIANG PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Enzymatic activity of the class I PI3K isoforms in the presence of the compounds of Table 1 above was measured using a time-resolved fluorescence res...


US Patent US10792283 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM464397
PNG
(US10792283, Compound 5)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1cc2ccc(F)cc2nc1-c1cccc(F)c1
Show InChI InChI=1S/C22H17F2N7/c1-11(28-21-17(10-25)20(26)30-22(27)31-21)16-8-12-5-6-15(24)9-18(12)29-19(16)13-3-2-4-14(23)7-13/h2-9,11H,1H3,(H5,26,27,28,30,31)/t11-/m0/s1
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US Patent
n/an/a 0.140n/an/an/an/an/an/a



HANGZHOU ZHENGXIANG PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Enzymatic activity of the class I PI3K isoforms in the presence of the compounds of Table 1 above was measured using a time-resolved fluorescence res...


US Patent US10792283 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM464395
PNG
(US10792283, Compound 3)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1cc2ccc(F)cc2nc1-c1cc(F)cc(F)c1
Show InChI InChI=1S/C22H16F3N7/c1-10(29-21-17(9-26)20(27)31-22(28)32-21)16-6-11-2-3-13(23)8-18(11)30-19(16)12-4-14(24)7-15(25)5-12/h2-8,10H,1H3,(H5,27,28,29,31,32)/t10-/m0/s1
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US Patent
n/an/a 0.240n/an/an/an/an/an/a



HANGZHOU ZHENGXIANG PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Enzymatic activity of the class I PI3K isoforms in the presence of the compounds of Table 1 above was measured using a time-resolved fluorescence res...


US Patent US10792283 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM464396
PNG
(US10792283, Compound 4)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1cc2ccc(F)cc2nc1-c1ccccc1S(C)(=O)=O
Show InChI InChI=1S/C23H20FN7O2S/c1-12(28-22-17(11-25)21(26)30-23(27)31-22)16-9-13-7-8-14(24)10-18(13)29-20(16)15-5-3-4-6-19(15)34(2,32)33/h3-10,12H,1-2H3,(H5,26,27,28,30,31)/t12-/m0/s1
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US Patent
n/an/a 0.270n/an/an/an/an/an/a



HANGZHOU ZHENGXIANG PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Enzymatic activity of the class I PI3K isoforms in the presence of the compounds of Table 1 above was measured using a time-resolved fluorescence res...


US Patent US10792283 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM464400
PNG
(US10792283, Compound 8)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1cc2cccc(Cl)c2nc1-c1ccccn1
Show InChI InChI=1S/C21H17ClN8/c1-11(27-20-14(10-23)19(24)29-21(25)30-20)13-9-12-5-4-6-15(22)17(12)28-18(13)16-7-2-3-8-26-16/h2-9,11H,1H3,(H5,24,25,27,29,30)/t11-/m0/s1
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PC cid
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US Patent
n/an/a 0.970n/an/an/an/an/an/a



HANGZHOU ZHENGXIANG PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Enzymatic activity of the class I PI3K isoforms in the presence of the compounds of Table 1 above was measured using a time-resolved fluorescence res...


US Patent US10792283 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM464399
PNG
(US10792283, Compound 7)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1cc2cccc(F)c2nc1-c1ccccc1S(C)(=O)=O
Show InChI InChI=1S/C23H20FN7O2S/c1-12(28-22-16(11-25)21(26)30-23(27)31-22)15-10-13-6-5-8-17(24)19(13)29-20(15)14-7-3-4-9-18(14)34(2,32)33/h3-10,12H,1-2H3,(H5,26,27,28,30,31)/t12-/m0/s1
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US Patent
n/an/a 2.10n/an/an/an/an/an/a



HANGZHOU ZHENGXIANG PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Enzymatic activity of the class I PI3K isoforms in the presence of the compounds of Table 1 above was measured using a time-resolved fluorescence res...


US Patent US10792283 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%