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Patent code US10793528

Compile Data Set for Download or QSAR
Found 150 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prepronociceptin


(Human)
BDBM464492
PNG
(US10793528, Example SC_5066)
Show SMILES CCN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2C)CC1)c1ccccc1
Show InChI InChI=1S/C23H36N4O2/c1-6-25(4)23(18-10-8-7-9-11-18)14-12-22(13-15-23)17-27(20(29)26(22)5)16-21(2,3)19(24)28/h7-11H,6,12-17H2,1-5H3,(H2,24,28)/t22-,23+
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0n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464503
PNG
(US10793528, Example SC_5078)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2(CCC2)C#N)CC1)c1ccccc1
Show InChI InChI=1S/C27H39N5O2/c1-24(2,22(29)33)18-31-20-26(32(23(31)34)19-25(17-28)11-8-12-25)13-15-27(16-14-26,30(3)4)21-9-6-5-7-10-21/h5-7,9-10H,8,11-16,18-20H2,1-4H3,(H2,29,33)/t26-,27+
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0.5n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464438
PNG
(US10793528, Example SC_5008)
Show SMILES COc1ccc(NC(=O)CCN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCC3)C2=O)nc1
Show InChI InChI=1S/C30H41N5O3/c1-33(2)30(24-10-5-4-6-11-24)17-15-29(16-18-30)22-34(28(37)35(29)21-23-8-7-9-23)19-14-27(36)32-26-13-12-25(38-3)20-31-26/h4-6,10-13,20,23H,7-9,14-19,21-22H2,1-3H3,(H,31,32,36)/t29-,30+
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Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464476
PNG
(US10793528, Example SC_5046)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H40N4O2/c1-24(2,22(27)31)18-29-19-25(30(23(29)32)17-20-9-8-10-20)13-15-26(16-14-25,28(3)4)21-11-6-5-7-12-21/h5-7,11-12,20H,8-10,13-19H2,1-4H3,(H2,27,31)/t25-,26+
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Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464494
PNG
(US10793528, Example SC_5069)
Show SMILES CCN[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2)CC1)c1ccccc1
Show InChI InChI=1S/C21H32N4O2/c1-4-23-21(16-8-6-5-7-9-16)12-10-20(11-13-21)15-25(18(27)24-20)14-19(2,3)17(22)26/h5-9,23H,4,10-15H2,1-3H3,(H2,22,26)(H,24,27)/t20-,21+
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1n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464434
PNG
(US10793528, Example SC_5004)
Show SMILES COc1ccc(NC(=O)CCN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCC3)C2=O)cn1
Show InChI InChI=1S/C30H41N5O3/c1-33(2)30(24-10-5-4-6-11-24)17-15-29(16-18-30)22-34(28(37)35(29)21-23-8-7-9-23)19-14-26(36)32-25-12-13-27(38-3)31-20-25/h4-6,10-13,20,23H,7-9,14-19,21-22H2,1-3H3,(H,32,36)/t29-,30+
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1.10n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464435
PNG
(US10793528, Example SC_5005)
Show SMILES COc1cnccc1NC(=O)CCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C30H41N5O3/c1-33(2)30(24-10-5-4-6-11-24)16-14-29(15-17-30)22-34(28(37)35(29)21-23-8-7-9-23)19-13-27(36)32-25-12-18-31-20-26(25)38-3/h4-6,10-12,18,20,23H,7-9,13-17,19,21-22H2,1-3H3,(H,31,32,36)/t29-,30+
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Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464480
PNG
(US10793528, Example SC_5049)
Show SMILES CNC(=O)CCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C25H38N4O2/c1-26-22(30)12-17-28-19-24(29(23(28)31)18-20-8-7-9-20)13-15-25(16-14-24,27(2)3)21-10-5-4-6-11-21/h4-6,10-11,20H,7-9,12-19H2,1-3H3,(H,26,30)/t24-,25+
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1.5n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464448
PNG
(US10793528, Example SC_5018)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)NCC3(O)CCC3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H44N4O3/c1-31(2)29(24-10-4-3-5-11-24)17-15-27(16-18-29)22-32(26(35)33(27)20-23-8-6-9-23)19-12-25(34)30-21-28(36)13-7-14-28/h3-5,10-11,23,36H,6-9,12-22H2,1-2H3,(H,30,34)/t27-,29+
PDB

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1.70n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464439
PNG
(US10793528, Example SC_5009)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)Nc3ccc(nc3)S(C)(=O)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H41N5O4S/c1-33(2)30(24-10-5-4-6-11-24)17-15-29(16-18-30)22-34(28(37)35(29)21-23-8-7-9-23)19-14-26(36)32-25-12-13-27(31-20-25)40(3,38)39/h4-6,10-13,20,23H,7-9,14-19,21-22H2,1-3H3,(H,32,36)/t29-,30+
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1.80n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464436
PNG
(US10793528, Example SC_5006)
Show SMILES COc1ccc(NC(=O)CCN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCC3)C2=O)nn1
Show InChI InChI=1S/C29H40N6O3/c1-33(2)29(23-10-5-4-6-11-23)17-15-28(16-18-29)21-34(27(37)35(28)20-22-8-7-9-22)19-14-25(36)30-24-12-13-26(38-3)32-31-24/h4-6,10-13,22H,7-9,14-21H2,1-3H3,(H,30,31,36)/t28-,29+
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1.90n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464437
PNG
(US10793528, Example SC_5007)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)Nc3ccc(cn3)S(C)(=O)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H41N5O4S/c1-33(2)30(24-10-5-4-6-11-24)17-15-29(16-18-30)22-34(28(37)35(29)21-23-8-7-9-23)19-14-27(36)32-26-13-12-25(20-31-26)40(3,38)39/h4-6,10-13,20,23H,7-9,14-19,21-22H2,1-3H3,(H,31,32,36)/t29-,30+
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Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464440
PNG
(US10793528, Example SC_5010)
Show SMILES COc1cncc(NC(=O)CCN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCC3)C2=O)n1
Show InChI InChI=1S/C29H40N6O3/c1-33(2)29(23-10-5-4-6-11-23)15-13-28(14-16-29)21-34(27(37)35(28)20-22-8-7-9-22)17-12-25(36)31-24-18-30-19-26(32-24)38-3/h4-6,10-11,18-19,22H,7-9,12-17,20-21H2,1-3H3,(H,31,32,36)/t28-,29+
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464433
PNG
(US10793528, Example SC_5003)
Show SMILES COc1cc(NC(=O)CCN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCC3)C2=O)ccn1
Show InChI InChI=1S/C30H41N5O3/c1-33(2)30(24-10-5-4-6-11-24)16-14-29(15-17-30)22-34(28(37)35(29)21-23-8-7-9-23)19-13-26(36)32-25-12-18-31-27(20-25)38-3/h4-6,10-12,18,20,23H,7-9,13-17,19,21-22H2,1-3H3,(H,31,32,36)/t29-,30+
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Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464447
PNG
(US10793528, Example SC_5017)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)N3CCCC(O)C3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H44N4O3/c1-30(2)29(24-10-4-3-5-11-24)16-14-28(15-17-29)22-32(27(36)33(28)20-23-8-6-9-23)19-13-26(35)31-18-7-12-25(34)21-31/h3-5,10-11,23,25,34H,6-9,12-22H2,1-2H3/t25?,28-,29+
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Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464441
PNG
(US10793528, Example SC_5011)
Show SMILES COc1ccnc(NC(=O)CCN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCC3)C2=O)c1
Show InChI InChI=1S/C30H41N5O3/c1-33(2)30(24-10-5-4-6-11-24)16-14-29(15-17-30)22-34(28(37)35(29)21-23-8-7-9-23)19-13-27(36)32-26-20-25(38-3)12-18-31-26/h4-6,10-12,18,20,23H,7-9,13-17,19,21-22H2,1-3H3,(H,31,32,36)/t29-,30+
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Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464449
PNG
(US10793528, Example SC_5019)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)N3CCn4ncnc4C3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H41N7O2/c1-32(2)29(24-9-4-3-5-10-24)14-12-28(13-15-29)21-34(27(38)35(28)19-23-7-6-8-23)16-11-26(37)33-17-18-36-25(20-33)30-22-31-36/h3-5,9-10,22-23H,6-8,11-21H2,1-2H3/t28-,29+
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Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464491
PNG
(US10793528, Example SC_5064)
Show SMILES CCN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2)CC1)c1ccccc1
Show InChI InChI=1S/C22H34N4O2/c1-5-25(4)22(17-9-7-6-8-10-17)13-11-21(12-14-22)16-26(19(28)24-21)15-20(2,3)18(23)27/h6-10H,5,11-16H2,1-4H3,(H2,23,27)(H,24,28)/t21-,22+
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Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464491
PNG
(US10793528, Example SC_5064)
Show SMILES CCN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2)CC1)c1ccccc1
Show InChI InChI=1S/C22H34N4O2/c1-5-25(4)22(17-9-7-6-8-10-17)13-11-21(12-14-22)16-26(19(28)24-21)15-20(2,3)18(23)27/h6-10H,5,11-16H2,1-4H3,(H2,23,27)(H,24,28)/t21-,22+
PDB

NCI pathway
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3n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464451
PNG
(US10793528, Example SC_5022)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)Nc3cnc(nc3)C#N)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H37N7O3/c1-34(2)29(22-7-4-3-5-8-22)14-12-27(13-15-29)20-35(26(38)36(27)21-28(39)10-6-11-28)16-9-25(37)33-23-18-31-24(17-30)32-19-23/h3-5,7-8,18-19,39H,6,9-16,20-21H2,1-2H3,(H,33,37)/t27-,29+
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3.10n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464448
PNG
(US10793528, Example SC_5018)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)NCC3(O)CCC3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H44N4O3/c1-31(2)29(24-10-4-3-5-11-24)17-15-27(16-18-29)22-32(26(35)33(27)20-23-8-6-9-23)19-12-25(34)30-21-28(36)13-7-14-28/h3-5,10-11,23,36H,6-9,12-22H2,1-2H3,(H,30,34)/t27-,29+
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3.20n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464481
PNG
(US10793528, Example SC_5051)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)Nc3cncnc3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H38N6O3/c1-32(2)28(22-7-4-3-5-8-22)14-12-26(13-15-28)19-33(25(36)34(26)20-27(37)10-6-11-27)16-9-24(35)31-23-17-29-21-30-18-23/h3-5,7-8,17-18,21,37H,6,9-16,19-20H2,1-2H3,(H,31,35)/t26-,28+
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3.60n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464443
PNG
(US10793528, Example SC_5013)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)NCc3ncco3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H39N5O3/c1-31(2)28(23-9-4-3-5-10-23)14-12-27(13-15-28)21-32(26(35)33(27)20-22-7-6-8-22)17-11-24(34)30-19-25-29-16-18-36-25/h3-5,9-10,16,18,22H,6-8,11-15,17,19-21H2,1-2H3,(H,30,34)/t27-,28+
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464431
PNG
(US10793528, Example SC_5001)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)Nc3cccnn3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H38N6O3/c1-32(2)28(22-8-4-3-5-9-22)16-14-26(15-17-28)20-33(25(36)34(26)21-27(37)12-7-13-27)19-11-24(35)30-23-10-6-18-29-31-23/h3-6,8-10,18,37H,7,11-17,19-21H2,1-2H3,(H,30,31,35)/t26-,28+
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GRÜNENTHAL GMBH

US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464466
PNG
(US10793528, Example SC_5036)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)Nc3cccnc3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H39N5O3/c1-32(2)29(23-8-4-3-5-9-23)16-14-27(15-17-29)21-33(26(36)34(27)22-28(37)12-7-13-28)19-11-25(35)31-24-10-6-18-30-20-24/h3-6,8-10,18,20,37H,7,11-17,19,21-22H2,1-2H3,(H,31,35)/t27-,29+
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Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464474
PNG
(US10793528, Example SC_5044)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)Nc3ccccn3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H39N5O3/c1-32(2)29(23-9-4-3-5-10-23)17-15-27(16-18-29)21-33(26(36)34(27)22-28(37)13-8-14-28)20-12-25(35)31-24-11-6-7-19-30-24/h3-7,9-11,19,37H,8,12-18,20-22H2,1-2H3,(H,30,31,35)/t27-,29+
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Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464478
PNG
(US10793528, Example SC_5047)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C24H36N4O2/c1-26(2)24(20-9-4-3-5-10-20)14-12-23(13-15-24)18-27(16-11-21(25)29)22(30)28(23)17-19-7-6-8-19/h3-5,9-10,19H,6-8,11-18H2,1-2H3,(H2,25,29)/t23-,24+
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Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464442
PNG
(US10793528, Example SC_5012)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)NCc3cnco3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H39N5O3/c1-31(2)28(23-9-4-3-5-10-23)14-12-27(13-15-28)20-32(26(35)33(27)19-22-7-6-8-22)16-11-25(34)30-18-24-17-29-21-36-24/h3-5,9-10,17,21-22H,6-8,11-16,18-20H2,1-2H3,(H,30,34)/t27-,28+
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Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464444
PNG
(US10793528, Example SC_5014)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)N3CC[C@H](O)[C@@H](O)C3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H44N4O4/c1-30(2)29(23-9-4-3-5-10-23)15-13-28(14-16-29)21-32(27(37)33(28)19-22-7-6-8-22)18-12-26(36)31-17-11-24(34)25(35)20-31/h3-5,9-10,22,24-25,34-35H,6-8,11-21H2,1-2H3/t24-,25-,28-,29+/m0/s1
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Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464492
PNG
(US10793528, Example SC_5066)
Show SMILES CCN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2C)CC1)c1ccccc1
Show InChI InChI=1S/C23H36N4O2/c1-6-25(4)23(18-10-8-7-9-11-18)14-12-22(13-15-23)17-27(20(29)26(22)5)16-21(2,3)19(24)28/h7-11H,6,12-17H2,1-5H3,(H2,24,28)/t22-,23+
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Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464501
PNG
(US10793528, Example SC_5076)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(=O)N3CCOCC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H46N4O4/c1-27(2,25(35)32-17-19-38-20-18-32)21-33-22-28(34(26(33)36)23-29(37)11-8-12-29)13-15-30(16-14-28,31(3)4)24-9-6-5-7-10-24/h5-7,9-10,37H,8,11-23H2,1-4H3/t28-,30+
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Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464494
PNG
(US10793528, Example SC_5069)
Show SMILES CCN[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2)CC1)c1ccccc1
Show InChI InChI=1S/C21H32N4O2/c1-4-23-21(16-8-6-5-7-9-16)12-10-20(11-13-21)15-25(18(27)24-20)14-19(2,3)17(22)26/h5-9,23H,4,10-15H2,1-3H3,(H2,22,26)(H,24,27)/t20-,21+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464486
PNG
(US10793528, Example SC_5056)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(=O)NCC(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H43N5O3/c1-26(2,24(35)30-17-23(29)34)19-32-20-27(33(25(32)36)18-21-9-8-10-21)13-15-28(16-14-27,31(3)4)22-11-6-5-7-12-22/h5-7,11-12,21H,8-10,13-20H2,1-4H3,(H2,29,34)(H,30,35)/t27-,28+
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464447
PNG
(US10793528, Example SC_5017)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)N3CCCC(O)C3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H44N4O3/c1-30(2)29(24-10-4-3-5-11-24)16-14-28(15-17-29)22-32(27(36)33(28)20-23-8-6-9-23)19-13-26(35)31-18-7-12-25(34)21-31/h3-5,10-11,23,25,34H,6-9,12-22H2,1-2H3/t25?,28-,29+
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Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464467
PNG
(US10793528, Example SC_5037)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)Nc3ccncc3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H39N5O3/c1-32(2)29(23-7-4-3-5-8-23)16-14-27(15-17-29)21-33(26(36)34(27)22-28(37)12-6-13-28)20-11-25(35)31-24-9-18-30-19-10-24/h3-5,7-10,18-19,37H,6,11-17,20-22H2,1-2H3,(H,30,31,35)/t27-,29+
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Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464450
PNG
(US10793528, Example SC_5020)
Show SMILES CN(C)C(=O)CCNC(=O)CCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C29H45N5O3/c1-31(2)26(36)13-19-30-25(35)14-20-33-22-28(34(27(33)37)21-23-9-8-10-23)15-17-29(18-16-28,32(3)4)24-11-6-5-7-12-24/h5-7,11-12,23H,8-10,13-22H2,1-4H3,(H,30,35)/t28-,29+
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464443
PNG
(US10793528, Example SC_5013)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)NCc3ncco3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H39N5O3/c1-31(2)28(23-9-4-3-5-10-23)14-12-27(13-15-28)21-32(26(35)33(27)20-22-7-6-8-22)17-11-24(34)30-19-25-29-16-18-36-25/h3-5,9-10,16,18,22H,6-8,11-15,17,19-21H2,1-2H3,(H,30,34)/t27-,28+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464454
PNG
(US10793528, Example SC_5024)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)Nc3nccc(O)n3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H38N6O4/c1-32(2)28(21-7-4-3-5-8-21)15-13-26(14-16-28)19-33(25(37)34(26)20-27(38)11-6-12-27)18-10-23(36)31-24-29-17-9-22(35)30-24/h3-5,7-9,17,38H,6,10-16,18-20H2,1-2H3,(H2,29,30,31,35,36)/t26-,28+
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Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464434
PNG
(US10793528, Example SC_5004)
Show SMILES COc1ccc(NC(=O)CCN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCC3)C2=O)cn1
Show InChI InChI=1S/C30H41N5O3/c1-33(2)30(24-10-5-4-6-11-24)17-15-29(16-18-30)22-34(28(37)35(29)21-23-8-7-9-23)19-14-26(36)32-25-12-13-27(38-3)31-20-25/h4-6,10-13,20,23H,7-9,14-19,21-22H2,1-3H3,(H,32,36)/t29-,30+
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Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464445
PNG
(US10793528, Example SC_5015)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)N3C[C@H](O)[C@@H](O)C3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H42N4O4/c1-29(2)28(22-9-4-3-5-10-22)14-12-27(13-15-28)20-30(26(36)32(27)17-21-7-6-8-21)16-11-25(35)31-18-23(33)24(34)19-31/h3-5,9-10,21,23-24,33-34H,6-8,11-20H2,1-2H3/t23-,24-,27-,28+/m0/s1
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Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464493
PNG
(US10793528, Example SC_5067)
Show SMILES CN[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2)CC1)c1ccccc1
Show InChI InChI=1S/C20H30N4O2/c1-18(2,16(21)25)13-24-14-19(23-17(24)26)9-11-20(22-3,12-10-19)15-7-5-4-6-8-15/h4-8,22H,9-14H2,1-3H3,(H2,21,25)(H,23,26)/t19-,20+
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Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464480
PNG
(US10793528, Example SC_5049)
Show SMILES CNC(=O)CCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C25H38N4O2/c1-26-22(30)12-17-28-19-24(29(23(28)31)18-20-8-7-9-20)13-15-25(16-14-24,27(2)3)21-10-5-4-6-11-21/h4-6,10-11,20H,7-9,12-19H2,1-3H3,(H,26,30)/t24-,25+
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GRÜNENTHAL GMBH

US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464446
PNG
(US10793528, Example SC_5016)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)N3C[C@H](O)[C@H](O)C3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H42N4O4/c1-29(2)28(22-9-4-3-5-10-22)14-12-27(13-15-28)20-30(26(36)32(27)17-21-7-6-8-21)16-11-25(35)31-18-23(33)24(34)19-31/h3-5,9-10,21,23-24,33-34H,6-8,11-20H2,1-2H3/t23-,24+,27-,28+
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464485
PNG
(US10793528, Example SC_5055)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)NC3COC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H40N4O4/c1-29(2)27(21-7-4-3-5-8-21)14-12-25(13-15-27)19-30(16-9-23(32)28-22-17-35-18-22)24(33)31(25)20-26(34)10-6-11-26/h3-5,7-8,22,34H,6,9-20H2,1-2H3,(H,28,32)/t25-,27+
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Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464482
PNG
(US10793528, Example SC_5052)
Show SMILES CNC(=O)CCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2(O)CCC2)C1=O
Show InChI InChI=1S/C25H38N4O3/c1-26-21(30)10-17-28-18-23(29(22(28)31)19-24(32)11-7-12-24)13-15-25(16-14-23,27(2)3)20-8-5-4-6-9-20/h4-6,8-9,32H,7,10-19H2,1-3H3,(H,26,30)/t23-,25+
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Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464504
PNG
(US10793528, Example SC_5079)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(=O)N3CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H46N4O5S/c1-27(2,25(35)32-17-19-40(38,39)20-18-32)21-33-22-28(34(26(33)36)23-29(37)11-8-12-29)13-15-30(16-14-28,31(3)4)24-9-6-5-7-10-24/h5-7,9-10,37H,8,11-23H2,1-4H3/t28-,30+
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Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464508
PNG
(US10793528, Example SC_5084)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2CC2)CC1)c1cccc(F)c1
Show InChI InChI=1S/C25H37FN4O2/c1-23(2,21(27)31)16-29-17-24(30(22(29)32)15-18-8-9-18)10-12-25(13-11-24,28(3)4)19-6-5-7-20(26)14-19/h5-7,14,18H,8-13,15-17H2,1-4H3,(H2,27,31)/t24-,25+
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Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464432
PNG
(US10793528, Example SC_5002)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(N)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C24H36N4O3/c1-26(2)24(19-7-4-3-5-8-19)14-12-22(13-15-24)17-27(16-9-20(25)29)21(30)28(22)18-23(31)10-6-11-23/h3-5,7-8,31H,6,9-18H2,1-2H3,(H2,25,29)/t22-,24+
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Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464452
PNG
(US10793528, Example SC_5023)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)Nc3ncccn3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H38N6O3/c1-32(2)28(22-8-4-3-5-9-22)15-13-26(14-16-28)20-33(25(36)34(26)21-27(37)11-6-12-27)19-10-23(35)31-24-29-17-7-18-30-24/h3-5,7-9,17-18,37H,6,10-16,19-21H2,1-2H3,(H,29,30,31,35)/t26-,28+
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464502
PNG
(US10793528, Example SC_5077)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(=O)NCCO)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H44N4O4/c1-25(2,23(34)29-17-18-33)19-31-20-26(32(24(31)35)21-27(36)11-8-12-27)13-15-28(16-14-26,30(3)4)22-9-6-5-7-10-22/h5-7,9-10,33,36H,8,11-21H2,1-4H3,(H,29,34)/t26-,28+
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Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464483
PNG
(US10793528, Example SC_5053)
Show SMILES COCCNC(=O)CCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2(O)CCC2)C1=O
Show InChI InChI=1S/C27H42N4O4/c1-29(2)27(22-8-5-4-6-9-22)15-13-25(14-16-27)20-30(18-10-23(32)28-17-19-35-3)24(33)31(25)21-26(34)11-7-12-26/h4-6,8-9,34H,7,10-21H2,1-3H3,(H,28,32)/t25-,27+
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464456
PNG
(US10793528, Example SC_5026)
Show SMILES CN[C@]1(CCC2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H38N4O2/c1-23(2,21(26)30)17-28-18-24(29(22(28)31)16-19-8-7-9-19)12-14-25(27-3,15-13-24)20-10-5-4-6-11-20/h4-6,10-11,19,27H,7-9,12-18H2,1-3H3,(H2,26,30)/t24?,25-
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464484
PNG
(US10793528, Example SC_5054)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)NCCO)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H40N4O4/c1-28(2)26(21-7-4-3-5-8-21)14-12-24(13-15-26)19-29(17-9-22(32)27-16-18-31)23(33)30(24)20-25(34)10-6-11-25/h3-5,7-8,31,34H,6,9-20H2,1-2H3,(H,27,32)/t24-,26+
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464475
PNG
(US10793528, Example SC_5045)
Show SMILES CCN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H42N4O2/c1-5-29(4)27(22-12-7-6-8-13-22)16-14-26(15-17-27)20-30(19-25(2,3)23(28)32)24(33)31(26)18-21-10-9-11-21/h6-8,12-13,21H,5,9-11,14-20H2,1-4H3,(H2,28,32)/t26-,27+
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464440
PNG
(US10793528, Example SC_5010)
Show SMILES COc1cncc(NC(=O)CCN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCC3)C2=O)n1
Show InChI InChI=1S/C29H40N6O3/c1-33(2)29(23-10-5-4-6-11-23)15-13-28(14-16-29)21-34(27(37)35(28)20-22-8-7-9-22)17-12-25(36)31-24-18-30-19-26(32-24)38-3/h4-6,10-11,18-19,22H,7-9,12-17,20-21H2,1-3H3,(H,31,32,36)/t28-,29+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464488
PNG
(US10793528, Example SC_5058)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H40N4O3/c1-23(2,21(27)31)17-29-18-24(30(22(29)32)19-25(33)11-8-12-25)13-15-26(16-14-24,28(3)4)20-9-6-5-7-10-20/h5-7,9-10,33H,8,11-19H2,1-4H3,(H2,27,31)/t24-,26+
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464460
PNG
(US10793528, Example SC_5030)
Show SMILES CN[C@]1(CC[C@]2(CN(CCC(=O)Nc3cccnn3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H36N6O3/c1-28-27(21-7-3-2-4-8-21)15-13-25(14-16-27)19-32(24(35)33(25)20-26(36)11-6-12-26)18-10-23(34)30-22-9-5-17-29-31-22/h2-5,7-9,17,28,36H,6,10-16,18-20H2,1H3,(H,30,31,34)/t25-,27+
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Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464507
PNG
(US10793528, Example SC_5083)
Show SMILES CN(C)C(=O)CCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2cccc(F)c2)N(CC2CC2)C1=O
Show InChI InChI=1S/C25H37FN4O2/c1-27(2)22(31)10-15-29-18-24(30(23(29)32)17-19-8-9-19)11-13-25(14-12-24,28(3)4)20-6-5-7-21(26)16-20/h5-7,16,19H,8-15,17-18H2,1-4H3/t24-,25+
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464455
PNG
(US10793528, Example SC_5025)
Show SMILES COc1ccnc(NC(=O)CCN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3(O)CCC3)C2=O)n1
Show InChI InChI=1S/C29H40N6O4/c1-33(2)29(22-8-5-4-6-9-22)16-14-27(15-17-29)20-34(26(37)35(27)21-28(38)12-7-13-28)19-11-23(36)31-25-30-18-10-24(32-25)39-3/h4-6,8-10,18,38H,7,11-17,19-21H2,1-3H3,(H,30,31,32,36)/t27-,29+
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464498
PNG
(US10793528, Example SC_5073)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H38N4O2/c1-23(2,21(26)30)17-28-18-24(29(22(28)31)16-19-10-11-19)12-14-25(15-13-24,27(3)4)20-8-6-5-7-9-20/h5-9,19H,10-18H2,1-4H3,(H2,26,30)/t24-,25+
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464436
PNG
(US10793528, Example SC_5006)
Show SMILES COc1ccc(NC(=O)CCN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCC3)C2=O)nn1
Show InChI InChI=1S/C29H40N6O3/c1-33(2)29(23-10-5-4-6-11-23)17-15-28(16-18-29)21-34(27(37)35(28)20-22-8-7-9-22)19-14-25(36)30-24-12-13-26(38-3)32-31-24/h4-6,10-13,22H,7-9,14-21H2,1-3H3,(H,30,31,36)/t28-,29+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464445
PNG
(US10793528, Example SC_5015)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)N3C[C@H](O)[C@@H](O)C3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H42N4O4/c1-29(2)28(22-9-4-3-5-10-22)14-12-27(13-15-28)20-30(26(36)32(27)17-21-7-6-8-21)16-11-25(35)31-18-23(33)24(34)19-31/h3-5,9-10,21,23-24,33-34H,6-8,11-20H2,1-2H3/t23-,24-,27-,28+/m0/s1
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Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464438
PNG
(US10793528, Example SC_5008)
Show SMILES COc1ccc(NC(=O)CCN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCC3)C2=O)nc1
Show InChI InChI=1S/C30H41N5O3/c1-33(2)30(24-10-5-4-6-11-24)17-15-29(16-18-30)22-34(28(37)35(29)21-23-8-7-9-23)19-14-27(36)32-26-13-12-25(38-3)20-31-26/h4-6,10-13,20,23H,7-9,14-19,21-22H2,1-3H3,(H,31,32,36)/t29-,30+
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25n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464442
PNG
(US10793528, Example SC_5012)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)NCc3cnco3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H39N5O3/c1-31(2)28(23-9-4-3-5-10-23)14-12-27(13-15-28)20-32(26(35)33(27)19-22-7-6-8-22)16-11-25(34)30-18-24-17-29-21-36-24/h3-5,9-10,17,21-22H,6-8,11-16,18-20H2,1-2H3,(H,30,34)/t27-,28+
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28n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464446
PNG
(US10793528, Example SC_5016)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)N3C[C@H](O)[C@H](O)C3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H42N4O4/c1-29(2)28(22-9-4-3-5-10-22)14-12-27(13-15-28)20-30(26(36)32(27)17-21-7-6-8-21)16-11-25(35)31-18-23(33)24(34)19-31/h3-5,9-10,21,23-24,33-34H,6-8,11-20H2,1-2H3/t23-,24+,27-,28+
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31n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464444
PNG
(US10793528, Example SC_5014)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)N3CC[C@H](O)[C@@H](O)C3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H44N4O4/c1-30(2)29(23-9-4-3-5-10-23)15-13-28(14-16-29)21-32(27(37)33(28)19-22-7-6-8-22)18-12-26(36)31-17-11-24(34)25(35)20-31/h3-5,9-10,22,24-25,34-35H,6-8,11-21H2,1-2H3/t24-,25-,28-,29+/m0/s1
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33n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464467
PNG
(US10793528, Example SC_5037)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)Nc3ccncc3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H39N5O3/c1-32(2)29(23-7-4-3-5-8-23)16-14-27(15-17-29)21-33(26(36)34(27)22-28(37)12-6-13-28)20-11-25(35)31-24-9-18-30-19-10-24/h3-5,7-10,18-19,37H,6,11-17,20-22H2,1-2H3,(H,30,31,35)/t27-,29+
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40n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464439
PNG
(US10793528, Example SC_5009)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)Nc3ccc(nc3)S(C)(=O)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H41N5O4S/c1-33(2)30(24-10-5-4-6-11-24)17-15-29(16-18-30)22-34(28(37)35(29)21-23-8-7-9-23)19-14-26(36)32-25-12-13-27(31-20-25)40(3,38)39/h4-6,10-13,20,23H,7-9,14-19,21-22H2,1-3H3,(H,32,36)/t29-,30+
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43.5n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464433
PNG
(US10793528, Example SC_5003)
Show SMILES COc1cc(NC(=O)CCN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCC3)C2=O)ccn1
Show InChI InChI=1S/C30H41N5O3/c1-33(2)30(24-10-5-4-6-11-24)16-14-29(15-17-30)22-34(28(37)35(29)21-23-8-7-9-23)19-13-26(36)32-25-12-18-31-27(20-25)38-3/h4-6,10-12,18,20,23H,7-9,13-17,19,21-22H2,1-3H3,(H,31,32,36)/t29-,30+
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44.5n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464435
PNG
(US10793528, Example SC_5005)
Show SMILES COc1cnccc1NC(=O)CCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C30H41N5O3/c1-33(2)30(24-10-5-4-6-11-24)16-14-29(15-17-30)22-34(28(37)35(29)21-23-8-7-9-23)19-13-27(36)32-25-12-18-31-20-26(25)38-3/h4-6,10-12,18,20,23H,7-9,13-17,19,21-22H2,1-3H3,(H,31,32,36)/t29-,30+
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46.5n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464450
PNG
(US10793528, Example SC_5020)
Show SMILES CN(C)C(=O)CCNC(=O)CCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C29H45N5O3/c1-31(2)26(36)13-19-30-25(35)14-20-33-22-28(34(27(33)37)21-23-9-8-10-23)15-17-29(18-16-28,32(3)4)24-11-6-5-7-12-24/h5-7,11-12,23H,8-10,13-22H2,1-4H3,(H,30,35)/t28-,29+
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47.5n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464463
PNG
(US10793528, Example SC_5033)
Show SMILES COCCN1C(=O)N(CCC(=O)Nc2cncnc2)C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C26H36N6O3/c1-30(2)26(21-7-5-4-6-8-21)12-10-25(11-13-26)19-31(24(34)32(25)15-16-35-3)14-9-23(33)29-22-17-27-20-28-18-22/h4-8,17-18,20H,9-16,19H2,1-3H3,(H,29,33)/t25-,26+
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48.5n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464449
PNG
(US10793528, Example SC_5019)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)N3CCn4ncnc4C3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H41N7O2/c1-32(2)29(24-9-4-3-5-10-24)14-12-28(13-15-29)21-34(27(38)35(28)19-23-7-6-8-23)16-11-26(37)33-17-18-36-25(20-33)30-22-31-36/h3-5,9-10,22-23H,6-8,11-21H2,1-2H3/t28-,29+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464441
PNG
(US10793528, Example SC_5011)
Show SMILES COc1ccnc(NC(=O)CCN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCC3)C2=O)c1
Show InChI InChI=1S/C30H41N5O3/c1-33(2)30(24-10-5-4-6-11-24)16-14-29(15-17-30)22-34(28(37)35(29)21-23-8-7-9-23)19-13-27(36)32-26-20-25(38-3)12-18-31-26/h4-6,10-12,18,20,23H,7-9,13-17,19,21-22H2,1-3H3,(H,31,32,36)/t29-,30+
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51.5n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464483
PNG
(US10793528, Example SC_5053)
Show SMILES COCCNC(=O)CCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2(O)CCC2)C1=O
Show InChI InChI=1S/C27H42N4O4/c1-29(2)27(22-8-5-4-6-9-22)15-13-25(14-16-27)20-30(18-10-23(32)28-17-19-35-3)24(33)31(25)21-26(34)11-7-12-26/h4-6,8-9,34H,7,10-21H2,1-3H3,(H,28,32)/t25-,27+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464471
PNG
(US10793528, Example SC_5041)
Show SMILES COCCCN1C(=O)N(CCC(=O)N2CCNC(=O)C2)C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C27H41N5O4/c1-29(2)27(22-8-5-4-6-9-22)13-11-26(12-14-27)21-31(25(35)32(26)16-7-19-36-3)17-10-24(34)30-18-15-28-23(33)20-30/h4-6,8-9H,7,10-21H2,1-3H3,(H,28,33)/t26-,27+
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63.5n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464486
PNG
(US10793528, Example SC_5056)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(=O)NCC(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H43N5O3/c1-26(2,24(35)30-17-23(29)34)19-32-20-27(33(25(32)36)18-21-9-8-10-21)13-15-28(16-14-27,31(3)4)22-11-6-5-7-12-22/h5-7,11-12,21H,8-10,13-20H2,1-4H3,(H2,29,34)(H,30,35)/t27-,28+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464437
PNG
(US10793528, Example SC_5007)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)Nc3ccc(cn3)S(C)(=O)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H41N5O4S/c1-33(2)30(24-10-5-4-6-11-24)17-15-29(16-18-30)22-34(28(37)35(29)21-23-8-7-9-23)19-14-27(36)32-26-13-12-25(20-31-26)40(3,38)39/h4-6,10-13,20,23H,7-9,14-19,21-22H2,1-3H3,(H,31,32,36)/t29-,30+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464478
PNG
(US10793528, Example SC_5047)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C24H36N4O2/c1-26(2)24(20-9-4-3-5-10-20)14-12-23(13-15-24)18-27(16-11-21(25)29)22(30)28(23)17-19-7-6-8-19/h3-5,9-10,19H,6-8,11-18H2,1-2H3,(H2,25,29)/t23-,24+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464472
PNG
(US10793528, Example SC_5042)
Show SMILES COCCCN1C(=O)N(CCC(=O)N2CCC[C@@H]2C(N)=O)C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C28H43N5O4/c1-30(2)28(22-9-5-4-6-10-22)15-13-27(14-16-28)21-31(26(36)33(27)18-8-20-37-3)19-12-24(34)32-17-7-11-23(32)25(29)35/h4-6,9-10,23H,7-8,11-21H2,1-3H3,(H2,29,35)/t23-,27-,28+/m1/s1
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70.5n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464468
PNG
(US10793528, Example SC_5038)
Show SMILES COCCCN1C(=O)N(CCC(=O)NC(C)(C)C(N)=O)C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C27H43N5O4/c1-25(2,23(28)34)29-22(33)12-18-31-20-26(32(24(31)35)17-9-19-36-5)13-15-27(16-14-26,30(3)4)21-10-7-6-8-11-21/h6-8,10-11H,9,12-20H2,1-5H3,(H2,28,34)(H,29,33)/t26-,27+
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72.5n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464485
PNG
(US10793528, Example SC_5055)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)NC3COC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H40N4O4/c1-29(2)27(21-7-4-3-5-8-21)14-12-25(13-15-27)19-30(16-9-23(32)28-22-17-35-18-22)24(33)31(25)20-26(34)10-6-11-26/h3-5,7-8,22,34H,6,9-20H2,1-2H3,(H,28,32)/t25-,27+
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74n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464487
PNG
(US10793528, Example SC_5057)
Show SMILES CN[C@]1(CC[C@]2(CN(CC(C)(C)C(=O)NCC(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N5O3/c1-25(2,23(34)30-16-22(28)33)18-31-19-26(32(24(31)35)17-20-8-7-9-20)12-14-27(29-3,15-13-26)21-10-5-4-6-11-21/h4-6,10-11,20,29H,7-9,12-19H2,1-3H3,(H2,28,33)(H,30,34)/t26-,27+
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75.5n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464489
PNG
(US10793528, Example SC_5059)
Show SMILES CN[C@]1(CC[C@]2(CN(CCC(=O)NC3COC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H38N4O4/c1-27-26(20-6-3-2-4-7-20)13-11-24(12-14-26)18-29(15-8-22(31)28-21-16-34-17-21)23(32)30(24)19-25(33)9-5-10-25/h2-4,6-7,21,27,33H,5,8-19H2,1H3,(H,28,31)/t24-,26+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464451
PNG
(US10793528, Example SC_5022)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)Nc3cnc(nc3)C#N)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H37N7O3/c1-34(2)29(22-7-4-3-5-8-22)14-12-27(13-15-29)20-35(26(38)36(27)21-28(39)10-6-11-28)16-9-25(37)33-23-18-31-24(17-30)32-19-23/h3-5,7-8,18-19,39H,6,9-16,20-21H2,1-2H3,(H,33,37)/t27-,29+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464473
PNG
(US10793528, Example SC_5043)
Show SMILES COCCCN1C(=O)N(CCC(=O)NCC(N)=O)C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C25H39N5O4/c1-28(2)25(20-8-5-4-6-9-20)13-11-24(12-14-25)19-29(16-10-22(32)27-18-21(26)31)23(33)30(24)15-7-17-34-3/h4-6,8-9H,7,10-19H2,1-3H3,(H2,26,31)(H,27,32)/t24-,25+
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101n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464489
PNG
(US10793528, Example SC_5059)
Show SMILES CN[C@]1(CC[C@]2(CN(CCC(=O)NC3COC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H38N4O4/c1-27-26(20-6-3-2-4-7-20)13-11-24(12-14-26)18-29(15-8-22(31)28-21-16-34-17-21)23(32)30(24)19-25(33)9-5-10-25/h2-4,6-7,21,27,33H,5,8-19H2,1H3,(H,28,31)/t24-,26+
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112n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464476
PNG
(US10793528, Example SC_5046)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H40N4O2/c1-24(2,22(27)31)18-29-19-25(30(23(29)32)17-20-9-8-10-20)13-15-26(16-14-25,28(3)4)21-11-6-5-7-12-21/h5-7,11-12,20H,8-10,13-19H2,1-4H3,(H2,27,31)/t25-,26+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464470
PNG
(US10793528, Example SC_5040)
Show SMILES COCCCN1C(=O)N(CCC(=O)NCCO)C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C25H40N4O4/c1-27(2)25(21-8-5-4-6-9-21)13-11-24(12-14-25)20-28(17-10-22(31)26-15-18-30)23(32)29(24)16-7-19-33-3/h4-6,8-9,30H,7,10-20H2,1-3H3,(H,26,31)/t24-,25+
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464432
PNG
(US10793528, Example SC_5002)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(N)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C24H36N4O3/c1-26(2)24(19-7-4-3-5-8-19)14-12-22(13-15-24)17-27(16-9-20(25)29)21(30)28(22)18-23(31)10-6-11-23/h3-5,7-8,31H,6,9-18H2,1-2H3,(H2,25,29)/t22-,24+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464487
PNG
(US10793528, Example SC_5057)
Show SMILES CN[C@]1(CC[C@]2(CN(CC(C)(C)C(=O)NCC(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N5O3/c1-25(2,23(34)30-16-22(28)33)18-31-19-26(32(24(31)35)17-20-8-7-9-20)12-14-27(29-3,15-13-26)21-10-5-4-6-11-21/h4-6,10-11,20,29H,7-9,12-19H2,1-3H3,(H2,28,33)(H,30,34)/t26-,27+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464469
PNG
(US10793528, Example SC_5039)
Show SMILES COCCCN1C(=O)N(CCC(=O)NCCS(C)(=O)=O)C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C26H42N4O5S/c1-28(2)26(22-9-6-5-7-10-22)14-12-25(13-15-26)21-29(24(32)30(25)17-8-19-35-3)18-11-23(31)27-16-20-36(4,33)34/h5-7,9-10H,8,11-21H2,1-4H3,(H,27,31)/t25-,26+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464455
PNG
(US10793528, Example SC_5025)
Show SMILES COc1ccnc(NC(=O)CCN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3(O)CCC3)C2=O)n1
Show InChI InChI=1S/C29H40N6O4/c1-33(2)29(22-8-5-4-6-9-22)16-14-27(15-17-29)20-34(26(37)35(27)21-28(38)12-7-13-28)19-11-23(36)31-25-30-18-10-24(32-25)39-3/h4-6,8-10,18,38H,7,11-17,19-21H2,1-3H3,(H,30,31,32,36)/t27-,29+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464464
PNG
(US10793528, Example SC_5034)
Show SMILES COCCCN1C(=O)N(CC(C)(C)C(N)=O)C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C25H40N4O3/c1-23(2,21(26)30)18-28-19-24(29(22(28)31)16-9-17-32-5)12-14-25(15-13-24,27(3)4)20-10-7-6-8-11-20/h6-8,10-11H,9,12-19H2,1-5H3,(H2,26,30)/t24-,25+
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130n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464469
PNG
(US10793528, Example SC_5039)
Show SMILES COCCCN1C(=O)N(CCC(=O)NCCS(C)(=O)=O)C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C26H42N4O5S/c1-28(2)26(22-9-6-5-7-10-22)14-12-25(13-15-26)21-29(24(32)30(25)17-8-19-35-3)18-11-23(31)27-16-20-36(4,33)34/h5-7,9-10H,8,11-21H2,1-4H3,(H,27,31)/t25-,26+
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130n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464458
PNG
(US10793528, Example SC_5028)
Show SMILES CN[C@]1(CC[C@]2(CN(CCC(N)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C23H34N4O3/c1-25-23(18-6-3-2-4-7-18)13-11-21(12-14-23)16-26(15-8-19(24)28)20(29)27(21)17-22(30)9-5-10-22/h2-4,6-7,25,30H,5,8-17H2,1H3,(H2,24,28)/t21-,23+
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140n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464466
PNG
(US10793528, Example SC_5036)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)Nc3cccnc3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H39N5O3/c1-32(2)29(23-8-4-3-5-9-23)16-14-27(15-17-29)21-33(26(36)34(27)22-28(37)12-7-13-28)19-11-25(35)31-24-10-6-18-30-20-24/h3-6,8-10,18,20,37H,7,11-17,19,21-22H2,1-2H3,(H,31,35)/t27-,29+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464497
PNG
(US10793528, Example SC_5072)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2COC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H38N4O3/c1-23(2,21(26)30)17-28-18-24(29(22(28)31)14-19-15-32-16-19)10-12-25(13-11-24,27(3)4)20-8-6-5-7-9-20/h5-9,19H,10-18H2,1-4H3,(H2,26,30)/t24-,25+
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150n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464484
PNG
(US10793528, Example SC_5054)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)NCCO)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H40N4O4/c1-28(2)26(21-7-4-3-5-8-21)14-12-24(13-15-26)19-29(17-9-22(32)27-16-18-31)23(33)30(24)20-25(34)10-6-11-25/h3-5,7-8,31,34H,6,9-20H2,1-2H3,(H,27,32)/t24-,26+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464454
PNG
(US10793528, Example SC_5024)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)Nc3nccc(O)n3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H38N6O4/c1-32(2)28(21-7-4-3-5-8-21)15-13-26(14-16-28)19-33(25(37)34(26)20-27(38)11-6-12-27)18-10-23(36)31-24-29-17-9-22(35)30-24/h3-5,7-9,17,38H,6,10-16,18-20H2,1-2H3,(H2,29,30,31,35,36)/t26-,28+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464474
PNG
(US10793528, Example SC_5044)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)Nc3ccccn3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H39N5O3/c1-32(2)29(23-9-4-3-5-10-23)17-15-27(16-18-29)21-33(26(36)34(27)22-28(37)13-8-14-28)20-12-25(35)31-24-11-6-7-19-30-24/h3-7,9-11,19,37H,8,12-18,20-22H2,1-2H3,(H,30,31,35)/t27-,29+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464468
PNG
(US10793528, Example SC_5038)
Show SMILES COCCCN1C(=O)N(CCC(=O)NC(C)(C)C(N)=O)C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C27H43N5O4/c1-25(2,23(28)34)29-22(33)12-18-31-20-26(32(24(31)35)17-9-19-36-5)13-15-27(16-14-26,30(3)4)21-10-7-6-8-11-21/h6-8,10-11H,9,12-20H2,1-5H3,(H2,28,34)(H,29,33)/t26-,27+
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GRÜNENTHAL GMBH

US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464503
PNG
(US10793528, Example SC_5078)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2(CCC2)C#N)CC1)c1ccccc1
Show InChI InChI=1S/C27H39N5O2/c1-24(2,22(29)33)18-31-20-26(32(23(31)34)19-25(17-28)11-8-12-25)13-15-27(16-14-26,30(3)4)21-9-6-5-7-10-21/h5-7,9-10H,8,11-16,18-20H2,1-4H3,(H2,29,33)/t26-,27+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464472
PNG
(US10793528, Example SC_5042)
Show SMILES COCCCN1C(=O)N(CCC(=O)N2CCC[C@@H]2C(N)=O)C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C28H43N5O4/c1-30(2)28(22-9-5-4-6-10-22)15-13-27(14-16-28)21-31(26(36)33(27)18-8-20-37-3)19-12-24(34)32-17-7-11-23(32)25(29)35/h4-6,9-10,23H,7-8,11-21H2,1-3H3,(H2,29,35)/t23-,27-,28+/m1/s1
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464461
PNG
(US10793528, Example SC_5031)
Show SMILES COCCN1C(=O)N(CCC(=O)NCCO)C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C24H38N4O4/c1-26(2)24(20-7-5-4-6-8-20)12-10-23(11-13-24)19-27(15-9-21(30)25-14-17-29)22(31)28(23)16-18-32-3/h4-8,29H,9-19H2,1-3H3,(H,25,30)/t23-,24+
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464459
PNG
(US10793528, Example SC_5029)
Show SMILES CNC(=O)CCN1C[C@]2(CC[C@@](CC2)(NC)c2ccccc2)N(CC2(O)CCC2)C1=O
Show InChI InChI=1S/C24H36N4O3/c1-25-20(29)9-16-27-17-22(28(21(27)30)18-23(31)10-6-11-23)12-14-24(26-2,15-13-22)19-7-4-3-5-8-19/h3-5,7-8,26,31H,6,9-18H2,1-2H3,(H,25,29)/t22-,24+
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464473
PNG
(US10793528, Example SC_5043)
Show SMILES COCCCN1C(=O)N(CCC(=O)NCC(N)=O)C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C25H39N5O4/c1-28(2)25(20-8-5-4-6-9-20)13-11-24(12-14-25)19-29(16-10-22(32)27-18-21(26)31)23(33)30(24)15-7-17-34-3/h4-6,8-9H,7,10-19H2,1-3H3,(H2,26,31)(H,27,32)/t24-,25+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464457
PNG
(US10793528, Example SC_5027)
Show SMILES CN[C@]1(CC[C@]2(CN(CCC(=O)NCCO)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H38N4O4/c1-26-25(20-6-3-2-4-7-20)13-11-23(12-14-25)18-28(16-8-21(31)27-15-17-30)22(32)29(23)19-24(33)9-5-10-24/h2-4,6-7,26,30,33H,5,8-19H2,1H3,(H,27,31)/t23-,25+
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464462
PNG
(US10793528, Example SC_5032)
Show SMILES CNC(=O)CCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CCOC)C1=O
Show InChI InChI=1S/C23H36N4O3/c1-24-20(28)10-15-26-18-22(27(21(26)29)16-17-30-4)11-13-23(14-12-22,25(2)3)19-8-6-5-7-9-19/h5-9H,10-18H2,1-4H3,(H,24,28)/t22-,23+
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464465
PNG
(US10793528, Example SC_5035)
Show SMILES COCCN1C(=O)N(CC(C)(C)C(N)=O)C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C24H38N4O3/c1-22(2,20(25)29)17-27-18-23(28(21(27)30)15-16-31-5)11-13-24(14-12-23,26(3)4)19-9-7-6-8-10-19/h6-10H,11-18H2,1-5H3,(H2,25,29)/t23-,24+
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464495
PNG
(US10793528, Example SC_5070)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2)CC1)c1ccccc1
Show InChI InChI=1S/C21H32N4O2/c1-19(2,17(22)26)14-25-15-20(23-18(25)27)10-12-21(13-11-20,24(3)4)16-8-6-5-7-9-16/h5-9H,10-15H2,1-4H3,(H2,22,26)(H,23,27)/t20-,21+
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464452
PNG
(US10793528, Example SC_5023)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)Nc3ncccn3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H38N6O3/c1-32(2)28(22-8-4-3-5-9-22)15-13-26(14-16-28)20-33(25(36)34(26)21-27(37)11-6-12-27)19-10-23(35)31-24-29-17-7-18-30-24/h3-5,7-9,17-18,37H,6,10-16,19-21H2,1-2H3,(H,29,30,31,35)/t26-,28+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464482
PNG
(US10793528, Example SC_5052)
Show SMILES CNC(=O)CCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2(O)CCC2)C1=O
Show InChI InChI=1S/C25H38N4O3/c1-26-21(30)10-17-28-18-23(29(22(28)31)19-24(32)11-7-12-24)13-15-25(16-14-23,27(2)3)20-8-5-4-6-9-20/h4-6,8-9,32H,7,10-19H2,1-3H3,(H,26,30)/t23-,25+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464499
PNG
(US10793528, Example SC_5074)
Show SMILES CCN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H42N4O3/c1-5-29(4)27(21-10-7-6-8-11-21)16-14-25(15-17-27)19-30(18-24(2,3)22(28)32)23(33)31(25)20-26(34)12-9-13-26/h6-8,10-11,34H,5,9,12-20H2,1-4H3,(H2,28,32)/t25-,27+
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464490
PNG
(US10793528, Example SC_5060)
Show SMILES CN[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H38N4O3/c1-22(2,20(26)30)16-28-17-23(29(21(28)31)18-24(32)10-7-11-24)12-14-25(27-3,15-13-23)19-8-5-4-6-9-19/h4-6,8-9,27,32H,7,10-18H2,1-3H3,(H2,26,30)/t23-,25+
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464481
PNG
(US10793528, Example SC_5051)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)Nc3cncnc3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H38N6O3/c1-32(2)28(22-7-4-3-5-8-22)14-12-26(13-15-28)19-33(25(36)34(26)20-27(37)10-6-11-27)16-9-24(35)31-23-17-29-21-30-18-23/h3-5,7-8,17-18,21,37H,6,9-16,19-20H2,1-2H3,(H,31,35)/t26-,28+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464506
PNG
(US10793528, Example SC_5082)
Show SMILES CN(C)[C@@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2)CC1)c1ccccc1
Show InChI InChI=1S/C21H32N4O2/c1-19(2,17(22)26)14-25-15-20(23-18(25)27)10-12-21(13-11-20,24(3)4)16-8-6-5-7-9-16/h5-9H,10-15H2,1-4H3,(H2,22,26)(H,23,27)/t20-,21-
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464470
PNG
(US10793528, Example SC_5040)
Show SMILES COCCCN1C(=O)N(CCC(=O)NCCO)C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C25H40N4O4/c1-27(2)25(21-8-5-4-6-9-21)13-11-24(12-14-25)20-28(17-10-22(31)26-15-18-30)23(32)29(24)16-7-19-33-3/h4-6,8-9,30H,7,10-20H2,1-3H3,(H,26,31)/t24-,25+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464431
PNG
(US10793528, Example SC_5001)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC(=O)Nc3cccnn3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H38N6O3/c1-32(2)28(22-8-4-3-5-9-22)16-14-26(15-17-28)20-33(25(36)34(26)21-27(37)12-7-13-27)19-11-24(35)30-23-10-6-18-29-31-23/h3-6,8-10,18,37H,7,11-17,19-21H2,1-2H3,(H,30,31,35)/t26-,28+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464471
PNG
(US10793528, Example SC_5041)
Show SMILES COCCCN1C(=O)N(CCC(=O)N2CCNC(=O)C2)C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C27H41N5O4/c1-29(2)27(22-8-5-4-6-9-22)13-11-26(12-14-27)21-31(25(35)32(26)16-7-19-36-3)17-10-24(34)30-18-15-28-23(33)20-30/h4-6,8-9H,7,10-21H2,1-3H3,(H,28,33)/t26-,27+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464498
PNG
(US10793528, Example SC_5073)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H38N4O2/c1-23(2,21(26)30)17-28-18-24(29(22(28)31)16-19-10-11-19)12-14-25(15-13-24,27(3)4)20-8-6-5-7-9-20/h5-9,19H,10-18H2,1-4H3,(H2,26,30)/t24-,25+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464502
PNG
(US10793528, Example SC_5077)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(=O)NCCO)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H44N4O4/c1-25(2,23(34)29-17-18-33)19-31-20-26(32(24(31)35)21-27(36)11-8-12-27)13-15-28(16-14-26,30(3)4)22-9-6-5-7-10-22/h5-7,9-10,33,36H,8,11-21H2,1-4H3,(H,29,34)/t26-,28+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464504
PNG
(US10793528, Example SC_5079)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(=O)N3CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H46N4O5S/c1-27(2,25(35)32-17-19-40(38,39)20-18-32)21-33-22-28(34(26(33)36)23-29(37)11-8-12-29)13-15-30(16-14-28,31(3)4)24-9-6-5-7-10-24/h5-7,9-10,37H,8,11-23H2,1-4H3/t28-,30+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464461
PNG
(US10793528, Example SC_5031)
Show SMILES COCCN1C(=O)N(CCC(=O)NCCO)C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C24H38N4O4/c1-26(2)24(20-7-5-4-6-8-20)12-10-23(11-13-24)19-27(15-9-21(30)25-14-17-29)22(31)28(23)16-18-32-3/h4-8,29H,9-19H2,1-3H3,(H,25,30)/t23-,24+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464488
PNG
(US10793528, Example SC_5058)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H40N4O3/c1-23(2,21(27)31)17-29-18-24(30(22(29)32)19-25(33)11-8-12-25)13-15-26(16-14-24,28(3)4)20-9-6-5-7-10-20/h5-7,9-10,33H,8,11-19H2,1-4H3,(H2,27,31)/t24-,26+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464456
PNG
(US10793528, Example SC_5026)
Show SMILES CN[C@]1(CCC2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H38N4O2/c1-23(2,21(26)30)17-28-18-24(29(22(28)31)16-19-8-7-9-19)12-14-25(27-3,15-13-24)20-10-5-4-6-11-20/h4-6,10-11,19,27H,7-9,12-18H2,1-3H3,(H2,26,30)/t24?,25-
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464507
PNG
(US10793528, Example SC_5083)
Show SMILES CN(C)C(=O)CCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2cccc(F)c2)N(CC2CC2)C1=O
Show InChI InChI=1S/C25H37FN4O2/c1-27(2)22(31)10-15-29-18-24(30(23(29)32)17-19-8-9-19)11-13-25(14-12-24,28(3)4)20-6-5-7-21(26)16-20/h5-7,16,19H,8-15,17-18H2,1-4H3/t24-,25+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464496
PNG
(US10793528, Example SC_5071)
Show SMILES CCN[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H40N4O2/c1-4-28-26(21-11-6-5-7-12-21)15-13-25(14-16-26)19-29(18-24(2,3)22(27)31)23(32)30(25)17-20-9-8-10-20/h5-7,11-12,20,28H,4,8-10,13-19H2,1-3H3,(H2,27,31)/t25-,26+
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464501
PNG
(US10793528, Example SC_5076)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(=O)N3CCOCC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H46N4O4/c1-27(2,25(35)32-17-19-38-20-18-32)21-33-22-28(34(26(33)36)23-29(37)11-8-12-29)13-15-30(16-14-28,31(3)4)24-9-6-5-7-10-24/h5-7,9-10,37H,8,11-23H2,1-4H3/t28-,30+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464506
PNG
(US10793528, Example SC_5082)
Show SMILES CN(C)[C@@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2)CC1)c1ccccc1
Show InChI InChI=1S/C21H32N4O2/c1-19(2,17(22)26)14-25-15-20(23-18(25)27)10-12-21(13-11-20,24(3)4)16-8-6-5-7-9-16/h5-9H,10-15H2,1-4H3,(H2,22,26)(H,23,27)/t20-,21-
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464460
PNG
(US10793528, Example SC_5030)
Show SMILES CN[C@]1(CC[C@]2(CN(CCC(=O)Nc3cccnn3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H36N6O3/c1-28-27(21-7-3-2-4-8-21)15-13-25(14-16-27)19-32(24(35)33(25)20-26(36)11-6-12-26)18-10-23(34)30-22-9-5-17-29-31-22/h2-5,7-9,17,28,36H,6,10-16,18-20H2,1H3,(H,30,31,34)/t25-,27+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464505
PNG
(US10793528, Example SC_5081)
Show SMILES CN(C)[C@@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H40N4O3/c1-23(2,21(27)31)17-29-18-24(30(22(29)32)19-25(33)11-8-12-25)13-15-26(16-14-24,28(3)4)20-9-6-5-7-10-20/h5-7,9-10,33H,8,11-19H2,1-4H3,(H2,27,31)/t24-,26-
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464465
PNG
(US10793528, Example SC_5035)
Show SMILES COCCN1C(=O)N(CC(C)(C)C(N)=O)C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C24H38N4O3/c1-22(2,20(25)29)17-27-18-23(28(21(27)30)15-16-31-5)11-13-24(14-12-23,26(3)4)19-9-7-6-8-10-19/h6-10H,11-18H2,1-5H3,(H2,25,29)/t23-,24+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464458
PNG
(US10793528, Example SC_5028)
Show SMILES CN[C@]1(CC[C@]2(CN(CCC(N)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C23H34N4O3/c1-25-23(18-6-3-2-4-7-18)13-11-21(12-14-23)16-26(15-8-19(24)28)20(29)27(21)17-22(30)9-5-10-22/h2-4,6-7,25,30H,5,8-17H2,1H3,(H2,24,28)/t21-,23+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464475
PNG
(US10793528, Example SC_5045)
Show SMILES CCN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H42N4O2/c1-5-29(4)27(22-12-7-6-8-13-22)16-14-26(15-17-27)20-30(19-25(2,3)23(28)32)24(33)31(26)18-21-10-9-11-21/h6-8,12-13,21H,5,9-11,14-20H2,1-4H3,(H2,28,32)/t26-,27+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464463
PNG
(US10793528, Example SC_5033)
Show SMILES COCCN1C(=O)N(CCC(=O)Nc2cncnc2)C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C26H36N6O3/c1-30(2)26(21-7-5-4-6-8-21)12-10-25(11-13-26)19-31(24(34)32(25)15-16-35-3)14-9-23(33)29-22-17-27-20-28-18-22/h4-8,17-18,20H,9-16,19H2,1-3H3,(H,29,33)/t25-,26+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464462
PNG
(US10793528, Example SC_5032)
Show SMILES CNC(=O)CCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CCOC)C1=O
Show InChI InChI=1S/C23H36N4O3/c1-24-20(28)10-15-26-18-22(27(21(26)29)16-17-30-4)11-13-23(14-12-22,25(2)3)19-8-6-5-7-9-19/h5-9H,10-18H2,1-4H3,(H,24,28)/t22-,23+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464464
PNG
(US10793528, Example SC_5034)
Show SMILES COCCCN1C(=O)N(CC(C)(C)C(N)=O)C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C25H40N4O3/c1-23(2,21(26)30)18-28-19-24(29(22(28)31)16-9-17-32-5)12-14-25(15-13-24,27(3)4)20-10-7-6-8-11-20/h6-8,10-11H,9,12-19H2,1-5H3,(H2,26,30)/t24-,25+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464457
PNG
(US10793528, Example SC_5027)
Show SMILES CN[C@]1(CC[C@]2(CN(CCC(=O)NCCO)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H38N4O4/c1-26-25(20-6-3-2-4-7-20)13-11-23(12-14-25)18-28(16-8-21(31)27-15-17-30)22(32)29(23)19-24(33)9-5-10-24/h2-4,6-7,26,30,33H,5,8-19H2,1H3,(H,27,31)/t23-,25+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464479
PNG
(US10793528, Example SC_5048)
Show SMILES CNC(=O)CCN1C[C@]2(CC[C@@](CC2)(N(C)CC(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C28H44N4O2/c1-22(2)19-30(4)28(24-11-6-5-7-12-24)16-14-27(15-17-28)21-31(18-13-25(33)29-3)26(34)32(27)20-23-9-8-10-23/h5-7,11-12,22-23H,8-10,13-21H2,1-4H3,(H,29,33)/t27-,28+
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Prepronociceptin


(Human)
BDBM464493
PNG
(US10793528, Example SC_5067)
Show SMILES CN[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2)CC1)c1ccccc1
Show InChI InChI=1S/C20H30N4O2/c1-18(2,16(21)25)13-24-14-19(23-17(24)26)9-11-20(22-3,12-10-19)15-7-5-4-6-8-15/h4-8,22H,9-14H2,1-3H3,(H2,21,25)(H,23,26)/t19-,20+
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US Patent


Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464490
PNG
(US10793528, Example SC_5060)
Show SMILES CN[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H38N4O3/c1-22(2,20(26)30)16-28-17-23(29(21(28)31)18-24(32)10-7-11-24)12-14-25(27-3,15-13-23)19-8-5-4-6-9-19/h4-6,8-9,27,32H,7,10-18H2,1-3H3,(H2,26,30)/t23-,25+
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US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464459
PNG
(US10793528, Example SC_5029)
Show SMILES CNC(=O)CCN1C[C@]2(CC[C@@](CC2)(NC)c2ccccc2)N(CC2(O)CCC2)C1=O
Show InChI InChI=1S/C24H36N4O3/c1-25-20(29)9-16-27-17-22(28(21(27)30)18-23(31)10-6-11-23)12-14-24(26-2,15-13-22)19-7-4-3-5-8-19/h3-5,7-8,26,31H,6,9-18H2,1-2H3,(H,25,29)/t22-,24+
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1.64E+3n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464508
PNG
(US10793528, Example SC_5084)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2CC2)CC1)c1cccc(F)c1
Show InChI InChI=1S/C25H37FN4O2/c1-23(2,21(27)31)16-29-17-24(30(22(29)32)15-18-8-9-18)10-12-25(13-11-24,28(3)4)19-6-5-7-20(26)14-19/h5-7,14,18H,8-13,15-17H2,1-4H3,(H2,27,31)/t24-,25+
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2.48E+3n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464499
PNG
(US10793528, Example SC_5074)
Show SMILES CCN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H42N4O3/c1-5-29(4)27(21-10-7-6-8-11-21)16-14-25(15-17-27)19-30(18-24(2,3)22(28)32)23(33)31(25)20-26(34)12-9-13-26/h6-8,10-11,34H,5,9,12-20H2,1-4H3,(H2,28,32)/t25-,27+
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2.62E+3n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464496
PNG
(US10793528, Example SC_5071)
Show SMILES CCN[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H40N4O2/c1-4-28-26(21-11-6-5-7-12-21)15-13-25(14-16-26)19-29(18-24(2,3)22(27)31)23(32)30(25)17-20-9-8-10-20/h5-7,11-12,20,28H,4,8-10,13-19H2,1-3H3,(H2,27,31)/t25-,26+
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2.85E+3n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464505
PNG
(US10793528, Example SC_5081)
Show SMILES CN(C)[C@@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H40N4O3/c1-23(2,21(27)31)17-29-18-24(30(22(29)32)19-25(33)11-8-12-25)13-15-26(16-14-24,28(3)4)20-9-6-5-7-10-20/h5-7,9-10,33H,8,11-19H2,1-4H3,(H2,27,31)/t24-,26-
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4.03E+3n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464479
PNG
(US10793528, Example SC_5048)
Show SMILES CNC(=O)CCN1C[C@]2(CC[C@@](CC2)(N(C)CC(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C28H44N4O2/c1-22(2)19-30(4)28(24-11-6-5-7-12-24)16-14-27(15-17-28)21-31(18-13-25(33)29-3)26(34)32(27)20-23-9-8-10-23/h5-7,11-12,22-23H,8-10,13-21H2,1-4H3,(H,29,33)/t27-,28+
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4.15E+3n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464497
PNG
(US10793528, Example SC_5072)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2COC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H38N4O3/c1-23(2,21(26)30)17-28-18-24(29(22(28)31)14-19-15-32-16-19)10-12-25(13-11-24,27(3)4)20-8-6-5-7-9-20/h5-9,19H,10-18H2,1-4H3,(H2,26,30)/t24-,25+
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4.68E+3n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464495
PNG
(US10793528, Example SC_5070)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2)CC1)c1ccccc1
Show InChI InChI=1S/C21H32N4O2/c1-19(2,17(22)26)14-25-15-20(23-18(25)27)10-12-21(13-11-20,24(3)4)16-8-6-5-7-9-16/h5-9H,10-15H2,1-4H3,(H2,22,26)(H,23,27)/t20-,21+
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7.34E+3n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
MOP: The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH...


US Patent US10793528 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%