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Patent code US10793549

Compile Data Set for Download or QSAR
Found 63 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464537
PNG
(US10793549, Compound G-23)
Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(cc(O)c12)S(=O)(=O)C1(CC=C)CC1)-c1cnc(nc1)N1CCNCC1
Show InChI InChI=1S/C31H35N7O6S/c1-4-5-31(6-7-31)45(42,43)38-18-25(39)27-22(28(40)33-17-23-26(44-3)12-19(2)36-29(23)41)13-20(14-24(27)38)21-15-34-30(35-16-21)37-10-8-32-9-11-37/h4,12-16,18,32,39H,1,5-11,17H2,2-3H3,(H,33,40)(H,36,41)
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n/an/a 5n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464528
PNG
(US10793549, Compound G-14)
Show SMILES COc1cn(c2cc(cc(C(=O)NCc3c(C)cc(C)[nH]c3=O)c12)-c1ccc(nc1)N1CCN(C)CC1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C34H40N6O5S/c1-6-9-34(10-11-34)46(43,44)40-21-29(45-5)31-26(32(41)36-20-27-22(2)16-23(3)37-33(27)42)17-25(18-28(31)40)24-7-8-30(35-19-24)39-14-12-38(4)13-15-39/h6-8,16-19,21H,1,9-15,20H2,2-5H3,(H,36,41)(H,37,42)
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n/an/a 5n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464562
PNG
(US10793549, Compound G-63)
Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(cc(O)c12)S(=O)(=O)C1(CC=C)CC1)-c1ccc(nc1)-n1ccncc1
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n/an/a 5n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464564
PNG
(Preparation of 1-(1-allylcyclopropylsulfonyl)-6-(2...)
Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(cc(C)c12)S(=O)(=O)C1(CC=C)CC1)-c1cnc(nc1)N1CCN(CC1)C(C)C
Show InChI InChI=1S/C35H43N7O5S/c1-7-8-35(9-10-35)48(45,46)42-21-23(4)31-27(32(43)36-20-28-30(47-6)15-24(5)39-33(28)44)16-25(17-29(31)42)26-18-37-34(38-19-26)41-13-11-40(12-14-41)22(2)3/h7,15-19,21-22H,1,8-14,20H2,2-6H3,(H,36,43)(H,39,44)
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n/an/a 7n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464543
PNG
(US10793549, Compound G-29 | US10793549, Compound G...)
Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(cc(O)c12)S(=O)(=O)C1(CC=C)CC1)-c1ccc(CN2CCOCC2)nc1
Show InChI InChI=1S/C33H37N5O7S/c1-4-7-33(8-9-33)46(42,43)38-20-28(39)30-25(31(40)35-18-26-29(44-3)14-21(2)36-32(26)41)15-23(16-27(30)38)22-5-6-24(34-17-22)19-37-10-12-45-13-11-37/h4-6,14-17,20,39H,1,7-13,18-19H2,2-3H3,(H,35,40)(H,36,41)
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n/an/a 8n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464546
PNG
(US10793549, Compound G-32)
Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(cc(C)c12)S(=O)(=O)C1(CC=C)CC1)-c1ccc(CN(C)C)cc1
Show InChI InChI=1S/C33H38N4O5S/c1-7-12-33(13-14-33)43(40,41)37-19-21(2)30-26(31(38)34-18-27-29(42-6)15-22(3)35-32(27)39)16-25(17-28(30)37)24-10-8-23(9-11-24)20-36(4)5/h7-11,15-17,19H,1,12-14,18,20H2,2-6H3,(H,34,38)(H,35,39)
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n/an/a 8n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464542
PNG
(US10793549, Compound G-28)
Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(cc(C)c12)S(=O)(=O)C1(CC=C)CC1)-c1ccc(nc1)N1CCN(C)CC1
Show InChI InChI=1S/C34H40N6O5S/c1-6-9-34(10-11-34)46(43,44)40-21-22(2)31-26(32(41)36-20-27-29(45-5)16-23(3)37-33(27)42)17-25(18-28(31)40)24-7-8-30(35-19-24)39-14-12-38(4)13-15-39/h6-8,16-19,21H,1,9-15,20H2,2-5H3,(H,36,41)(H,37,42)
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n/an/a 9n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464554
PNG
(US10793549, Compound G-39)
Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(cc(O)c12)S(=O)(=O)C1(CC=C)CC1)-c1cncc(c1)N1CCN(C)CC1
Show InChI InChI=1S/C33H38N6O6S/c1-5-6-33(7-8-33)46(43,44)39-20-28(40)30-25(31(41)35-19-26-29(45-4)13-21(2)36-32(26)42)15-22(16-27(30)39)23-14-24(18-34-17-23)38-11-9-37(3)10-12-38/h5,13-18,20,40H,1,6-12,19H2,2-4H3,(H,35,41)(H,36,42)
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n/an/a 9n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464544
PNG
(US10793549, Compound G-30)
Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(cc(C)c12)S(=O)(=O)C1(CC=C)CC1)-c1cnc(nc1)N1CC(F)C1
Show InChI InChI=1S/C31H33FN6O5S/c1-5-6-31(7-8-31)44(41,42)38-15-18(2)27-23(28(39)33-14-24-26(43-4)9-19(3)36-29(24)40)10-20(11-25(27)38)21-12-34-30(35-13-21)37-16-22(32)17-37/h5,9-13,15,22H,1,6-8,14,16-17H2,2-4H3,(H,33,39)(H,36,40)
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n/an/a 9n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464543
PNG
(US10793549, Compound G-29 | US10793549, Compound G...)
Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(cc(O)c12)S(=O)(=O)C1(CC=C)CC1)-c1ccc(CN2CCOCC2)nc1
Show InChI InChI=1S/C33H37N5O7S/c1-4-7-33(8-9-33)46(42,43)38-20-28(39)30-25(31(40)35-18-26-29(44-3)14-21(2)36-32(26)41)15-23(16-27(30)38)22-5-6-24(34-17-22)19-37-10-12-45-13-11-37/h4-6,14-17,20,39H,1,7-13,18-19H2,2-3H3,(H,35,40)(H,36,41)
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n/an/a 10n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464550
PNG
(US10793549, Compound G-35)
Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(cc(C)c12)S(=O)(=O)C1(CC=C)CC1)-c1ccc(nc1)-n1ccn(C)cc1
Show InChI InChI=1S/C36H40N6O4S/c1-6-8-26-18-25(4)39-35(44)30(26)22-38-34(43)29-19-28(27-9-10-32(37-21-27)41-16-14-40(5)15-17-41)20-31-33(29)24(3)23-42(31)47(45,46)36(11-7-2)12-13-36/h7,9-10,14-21,23H,2,6,8,11-13,22H2,1,3-5H3,(H,38,43)(H,39,44)
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n/an/a 12n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464527
PNG
(US10793549, Compound G-13)
Show SMILES CN1CCN(CC1)c1ncc(cn1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2c(C)cn(c2c1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C33H39N7O4S/c1-6-7-33(8-9-33)45(43,44)40-20-22(3)29-26(30(41)34-19-27-21(2)14-23(4)37-31(27)42)15-24(16-28(29)40)25-17-35-32(36-18-25)39-12-10-38(5)11-13-39/h6,14-18,20H,1,7-13,19H2,2-5H3,(H,34,41)(H,37,42)
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n/an/a 13n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464515
PNG
(Preparation of 1-(1-cyclopropyl-3-butenylsulfonyl)...)
Show SMILES CN1CCN(CC1)c1ccc(cn1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2c(C)cn(c2c1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C34H40N6O4S/c1-6-9-34(10-11-34)45(43,44)40-21-23(3)31-27(32(41)36-20-28-22(2)16-24(4)37-33(28)42)17-26(18-29(31)40)25-7-8-30(35-19-25)39-14-12-38(5)13-15-39/h6-8,16-19,21H,1,9-15,20H2,2-5H3,(H,36,41)(H,37,42)
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n/an/a 14n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464555
PNG
(US10793549, Compound G-40)
Show SMILES CC(C)n1ccn(cc1)-c1ncc(cn1)-c1cc(C(=O)NCc2c(Cl)cc(C)[nH]c2=O)c2c(Cl)cn(c2c1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C33H33Cl2N7O4S/c1-5-6-33(7-8-33)47(45,46)42-19-27(35)29-24(30(43)36-18-25-26(34)13-21(4)39-31(25)44)14-22(15-28(29)42)23-16-37-32(38-17-23)41-11-9-40(10-12-41)20(2)3/h5,9-17,19-20H,1,6-8,18H2,2-4H3,(H,36,43)(H,39,44)
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n/an/a 15n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464570
PNG
(US10793549, Compound G-73)
Show SMILES CCn1ccn(cc1)-c1cc(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c2c(C)cn(c2c1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C30H35N5O5S/c1-6-8-30(9-10-30)41(38,39)35-19-20(3)27-23(16-22(17-25(27)35)34-13-11-33(7-2)12-14-34)28(36)31-18-24-26(40-5)15-21(4)32-29(24)37/h6,11-17,19H,1,7-10,18H2,2-5H3,(H,31,36)(H,32,37)
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n/an/a 15n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464551
PNG
(US10793549, Compound G-36)
Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(cc(C)c12)S(=O)(=O)C1(CC=C)CC1)-c1ccc(N)nc1
Show InChI InChI=1S/C29H31N5O5S/c1-5-8-29(9-10-29)40(37,38)34-16-17(2)26-21(12-20(13-23(26)34)19-6-7-25(30)31-14-19)27(35)32-15-22-24(39-4)11-18(3)33-28(22)36/h5-7,11-14,16H,1,8-10,15H2,2-4H3,(H2,30,31)(H,32,35)(H,33,36)
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n/an/a 16n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464552
PNG
(US10793549, Compound G-37)
Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(cc(O)c12)S(=O)(=O)C1(CC=C)CC1)-c1ccc(CCC(C)C)nc1
Show InChI InChI=1S/C33H38N4O6S/c1-6-11-33(12-13-33)44(41,42)37-19-28(38)30-25(31(39)35-18-26-29(43-5)14-21(4)36-32(26)40)15-23(16-27(30)37)22-8-10-24(34-17-22)9-7-20(2)3/h6,8,10,14-17,19-20,38H,1,7,9,11-13,18H2,2-5H3,(H,35,39)(H,36,40)
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n/an/a 17n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464519
PNG
(US10793549, Compound G-5)
Show SMILES CN(C)CCOc1ccc(cc1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2c(C)cn(c2c1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C34H40N4O5S/c1-7-12-34(13-14-34)44(41,42)38-21-23(3)31-28(32(39)35-20-29-22(2)17-24(4)36-33(29)40)18-26(19-30(31)38)25-8-10-27(11-9-25)43-16-15-37(5)6/h7-11,17-19,21H,1,12-16,20H2,2-6H3,(H,35,39)(H,36,40)
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n/an/a 17n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464563
PNG
(US10793549, Compound G-65)
Show SMILES Cc1cn(c2cc(cc(C(=O)NCc3c(C)cc(C)[nH]c3=O)c12)-c1cnc(nc1)-n1ccncc1)S(=O)(=O)C1(CC=C)CC1
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n/an/a 17n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464517
PNG
(US10793549, Compound G-17 | US10793549, Compound G...)
Show SMILES CN(C)Cc1ccc(cc1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2c(C)cn(c2c1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C33H38N4O4S/c1-7-12-33(13-14-33)42(40,41)37-19-22(3)30-27(31(38)34-18-28-21(2)15-23(4)35-32(28)39)16-26(17-29(30)37)25-10-8-24(9-11-25)20-36(5)6/h7-11,15-17,19H,1,12-14,18,20H2,2-6H3,(H,34,38)(H,35,39)
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n/an/a 19n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464558
PNG
(US10793549, Compound G-42)
Show SMILES Cc1cc(Cl)c(CNC(=O)c2cc(cc3n(cc(Cl)c23)S(=O)(=O)C2(CC=C)CC2)-c2ccc(nc2)-n2ccn(CC(C)(F)F)cc2)c(=O)[nH]1
Show InChI InChI=1S/C34H32Cl2F2N6O4S/c1-4-7-34(8-9-34)49(47,48)44-19-27(36)30-24(31(45)40-18-25-26(35)14-21(2)41-32(25)46)15-23(16-28(30)44)22-5-6-29(39-17-22)43-12-10-42(11-13-43)20-33(3,37)38/h4-6,10-17,19H,1,7-9,18,20H2,2-3H3,(H,40,45)(H,41,46)
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n/an/a 21n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464534
PNG
(US10793549, Compound G-20)
Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(cc(O)c12)S(=O)(=O)C1(CC=C)CC1)-c1ccc(nc1)N1CCN(C)CC1
Show InChI InChI=1S/C33H38N6O6S/c1-5-8-33(9-10-33)46(43,44)39-20-27(40)30-24(31(41)35-19-25-28(45-4)15-21(2)36-32(25)42)16-23(17-26(30)39)22-6-7-29(34-18-22)38-13-11-37(3)12-14-38/h5-7,15-18,20,40H,1,8-14,19H2,2-4H3,(H,35,41)(H,36,42)
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n/an/a 21n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464517
PNG
(US10793549, Compound G-17 | US10793549, Compound G...)
Show SMILES CN(C)Cc1ccc(cc1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2c(C)cn(c2c1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C33H38N4O4S/c1-7-12-33(13-14-33)42(40,41)37-19-22(3)30-27(31(38)34-18-28-21(2)15-23(4)35-32(28)39)16-26(17-29(30)37)25-10-8-24(9-11-25)20-36(5)6/h7-11,15-17,19H,1,12-14,18,20H2,2-6H3,(H,34,38)(H,35,39)
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n/an/a 22n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464530
PNG
(US10793549, Compound G-16)
Show SMILES CN(C)Cc1ccc(cc1F)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2c(C)cn(c2c1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C33H37FN4O4S/c1-7-10-33(11-12-33)43(41,42)38-18-21(3)30-26(31(39)35-17-27-20(2)13-22(4)36-32(27)40)14-25(16-29(30)38)23-8-9-24(19-37(5)6)28(34)15-23/h7-9,13-16,18H,1,10-12,17,19H2,2-6H3,(H,35,39)(H,36,40)
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n/an/a 23n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464569
PNG
(US10793549, Compound G-72)
Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(cc(C)c12)S(=O)(=O)C1(CC=C)CC1)-n1ccn(C)c(C)c1
Show InChI InChI=1S/C30H35N5O5S/c1-7-8-30(9-10-30)41(38,39)35-17-19(2)27-23(14-22(15-25(27)35)34-12-11-33(5)21(4)18-34)28(36)31-16-24-26(40-6)13-20(3)32-29(24)37/h7,11-15,17-18H,1,8-10,16H2,2-6H3,(H,31,36)(H,32,37)
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n/an/a 23n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464541
PNG
(US10793549, Compound G-27)
Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(cc(C)c12)S(=O)(=O)C1(CC=C)CC1)-c1ccc(nc1)-c1cccnc1
Show InChI InChI=1S/C34H33N5O5S/c1-5-10-34(11-12-34)45(42,43)39-20-21(2)31-26(32(40)37-19-27-30(44-4)14-22(3)38-33(27)41)15-25(16-29(31)39)23-8-9-28(36-18-23)24-7-6-13-35-17-24/h5-9,13-18,20H,1,10-12,19H2,2-4H3,(H,37,40)(H,38,41)
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n/an/a 24n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464529
PNG
(US10793549, Compound G-15 | US10793549, Compound G...)
Show SMILES CN(C)Cc1ccc(c(F)c1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2c(C)cn(c2c1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C33H37FN4O4S/c1-7-10-33(11-12-33)43(41,42)38-18-21(3)30-26(31(39)35-17-27-20(2)13-22(4)36-32(27)40)15-24(16-29(30)38)25-9-8-23(14-28(25)34)19-37(5)6/h7-9,13-16,18H,1,10-12,17,19H2,2-6H3,(H,35,39)(H,36,40)
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n/an/a 25n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464566
PNG
(Preparation of 1-(1-allylcyclopropylsulfonyl)-N-((...)
Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(cc(C)c12)S(=O)(=O)C1(CC=C)CC1)N1CCN(C)CC1
Show InChI InChI=1S/C29H37N5O5S/c1-6-7-29(8-9-29)40(37,38)34-18-19(2)26-22(15-21(16-24(26)34)33-12-10-32(4)11-13-33)27(35)30-17-23-25(39-5)14-20(3)31-28(23)36/h6,14-16,18H,1,7-13,17H2,2-5H3,(H,30,35)(H,31,36)
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n/an/a 26n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464567
PNG
(US10793549, Compound G-70)
Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(cc(C)c12)S(=O)(=O)C1(CC=C)CC1)-n1ccn(CC(C)(F)F)cc1
Show InChI InChI=1S/C31H35F2N5O5S/c1-6-7-31(8-9-31)44(41,42)38-18-20(2)27-23(28(39)34-17-24-26(43-5)14-21(3)35-29(24)40)15-22(16-25(27)38)37-12-10-36(11-13-37)19-30(4,32)33/h6,10-16,18H,1,7-9,17,19H2,2-5H3,(H,34,39)(H,35,40)
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n/an/a 27n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464568
PNG
(US10793549, Compound G-71)
Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(cc(C)c12)S(=O)(=O)C1(CC=C)CC1)-n1ccn(cc1)C(C)C
Show InChI InChI=1S/C31H37N5O5S/c1-7-8-31(9-10-31)42(39,40)36-19-21(4)28-24(29(37)32-18-25-27(41-6)15-22(5)33-30(25)38)16-23(17-26(28)36)35-13-11-34(12-14-35)20(2)3/h7,11-17,19-20H,1,8-10,18H2,2-6H3,(H,32,37)(H,33,38)
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n/an/a 27n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464516
PNG
(US10793549, Compound G-3)
Show SMILES Cc1cn(c2cc(cc(C(=O)NCc3c(C)cc(C)[nH]c3=O)c12)-c1ccc(CCN2CCOCC2)nc1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C35H41N5O5S/c1-5-9-35(10-11-35)46(43,44)40-22-24(3)32-29(33(41)37-21-30-23(2)17-25(4)38-34(30)42)18-27(19-31(32)40)26-6-7-28(36-20-26)8-12-39-13-15-45-16-14-39/h5-7,17-20,22H,1,8-16,21H2,2-4H3,(H,37,41)(H,38,42)
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n/an/a 28n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464561
PNG
(Preparation of 1-(1-allylcyclopropylsulfonyl)-N-((...)
Show SMILES CC(C)N1CCN(CC1)c1ccc(cn1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2c(C)cn(c2c1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C36H44N6O4S/c1-7-10-36(11-12-36)47(45,46)42-22-25(5)33-29(34(43)38-21-30-24(4)17-26(6)39-35(30)44)18-28(19-31(33)42)27-8-9-32(37-20-27)41-15-13-40(14-16-41)23(2)3/h7-9,17-20,22-23H,1,10-16,21H2,2-6H3,(H,38,43)(H,39,44)
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n/an/a 28n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464545
PNG
(US10793549, Compound G-31)
Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(cc(O)c12)S(=O)(=O)C1(CC=C)CC1)-c1cncc(F)c1
Show InChI InChI=1S/C28H27FN4O6S/c1-4-5-28(6-7-28)40(37,38)33-15-23(34)25-20(10-17(11-22(25)33)18-9-19(29)13-30-12-18)26(35)31-14-21-24(39-3)8-16(2)32-27(21)36/h4,8-13,15,34H,1,5-7,14H2,2-3H3,(H,31,35)(H,32,36)
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n/an/a 31n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464536
PNG
(US10793549, Compound G-22)
Show SMILES Cc1cn(c2cc(cc(C(=O)NCc3c(C)cc(C)[nH]c3=O)c12)-c1cnc(nc1)N1CCOCC1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C32H36N6O5S/c1-5-6-32(7-8-32)44(41,42)38-19-21(3)28-25(29(39)33-18-26-20(2)13-22(4)36-30(26)40)14-23(15-27(28)38)24-16-34-31(35-17-24)37-9-11-43-12-10-37/h5,13-17,19H,1,6-12,18H2,2-4H3,(H,33,39)(H,36,40)
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n/an/a 31n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464553
PNG
(US10793549, Compound G-38)
Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(cc(O)c12)S(=O)(=O)C1(CC=C)CC1)-c1ccc(nc1)N(C)C
Show InChI InChI=1S/C30H33N5O6S/c1-6-9-30(10-11-30)42(39,40)35-17-24(36)27-21(28(37)32-16-22-25(41-5)12-18(2)33-29(22)38)13-20(14-23(27)35)19-7-8-26(31-15-19)34(3)4/h6-8,12-15,17,36H,1,9-11,16H2,2-5H3,(H,32,37)(H,33,38)
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n/an/a 31n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464549
PNG
(US10793549, Compound G-34)
Show SMILES Cc1cn(c2cc(cc(C(=O)NCc3c(Cl)cc(C)[nH]c3=O)c12)-c1ccc(nc1)-n1ccn(C)cc1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C33H33ClN6O4S/c1-5-8-33(9-10-33)45(43,44)40-20-21(2)30-25(31(41)36-19-26-27(34)15-22(3)37-32(26)42)16-24(17-28(30)40)23-6-7-29(35-18-23)39-13-11-38(4)12-14-39/h5-7,11-18,20H,1,8-10,19H2,2-4H3,(H,36,41)(H,37,42)
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n/an/a 32n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464525
PNG
(US10793549, Compound G-11)
Show SMILES CN(C)CCCOc1ccc(cc1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2c(C)cn(c2c1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C35H42N4O5S/c1-7-13-35(14-15-35)45(42,43)39-22-24(3)32-29(33(40)36-21-30-23(2)18-25(4)37-34(30)41)19-27(20-31(32)39)26-9-11-28(12-10-26)44-17-8-16-38(5)6/h7,9-12,18-20,22H,1,8,13-17,21H2,2-6H3,(H,36,40)(H,37,41)
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n/an/a 32n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464538
PNG
(US10793549, Compound G-24)
Show SMILES Cc1cn(c2cc(cc(C(=O)NCc3c(C)cc(C)[nH]c3=O)c12)-c1cnc(nc1)N1CC(F)C1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C31H33FN6O4S/c1-5-6-31(7-8-31)43(41,42)38-15-19(3)27-24(28(39)33-14-25-18(2)9-20(4)36-29(25)40)10-21(11-26(27)38)22-12-34-30(35-13-22)37-16-23(32)17-37/h5,9-13,15,23H,1,6-8,14,16-17H2,2-4H3,(H,33,39)(H,36,40)
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n/an/a 32n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464559
PNG
(US10793549, Compound G-43)
Show SMILES CN1CCN(CC1)c1cc(ccn1)-c1cc(C(=O)NCc2c(O)cc(C)[nH]c2=O)c2c(O)cn(c2c1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C32H36N6O6S/c1-4-6-32(7-8-32)45(43,44)38-19-27(40)29-23(30(41)34-18-24-26(39)14-20(2)35-31(24)42)15-22(16-25(29)38)21-5-9-33-28(17-21)37-12-10-36(3)11-13-37/h4-5,9,14-17,19,40H,1,6-8,10-13,18H2,2-3H3,(H,34,41)(H2,35,39,42)
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n/an/a 33n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464521
PNG
(US10793549, Compound G-7)
Show SMILES Cc1cn(c2cc(cc(C(=O)NCc3c(C)cc(C)[nH]c3=O)c12)-c1cccnc1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C29H30N4O4S/c1-5-8-29(9-10-29)38(36,37)33-17-19(3)26-23(13-22(14-25(26)33)21-7-6-11-30-15-21)27(34)31-16-24-18(2)12-20(4)32-28(24)35/h5-7,11-15,17H,1,8-10,16H2,2-4H3,(H,31,34)(H,32,35)
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n/an/a 33n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464565
PNG
(Preparation of 1-(1-allylcyclopropylsulfonyl)-N-((...)
Show SMILES CN1CCN(CC1)c1ccc(cn1)-c1cc(C(=O)NCc2c(OC(F)F)cc(C)nc2OCc2ccccc2)c2c(C)cn(c2c1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C41H44F2N6O5S/c1-5-13-41(14-15-41)55(51,52)49-25-27(2)37-32(21-31(22-34(37)49)30-11-12-36(44-23-30)48-18-16-47(4)17-19-48)38(50)45-24-33-35(54-40(42)43)20-28(3)46-39(33)53-26-29-9-7-6-8-10-29/h5-12,20-23,25,40H,1,13-19,24,26H2,2-4H3,(H,45,50)
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n/an/a 34n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464523
PNG
(US10793549, Compound G-9)
Show SMILES Cc1cn(c2cc(cc(C(=O)NCc3c(C)cc(C)[nH]c3=O)c12)-c1ccc(N)nc1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C29H31N5O4S/c1-5-8-29(9-10-29)39(37,38)34-16-18(3)26-22(12-21(13-24(26)34)20-6-7-25(30)31-14-20)27(35)32-15-23-17(2)11-19(4)33-28(23)36/h5-7,11-14,16H,1,8-10,15H2,2-4H3,(H2,30,31)(H,32,35)(H,33,36)
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n/an/a 35n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464556
PNG
(US10793549, Compound G-41)
Show SMILES Cc1cn(c2cc(cc(C(=O)NCc3c(C)cc(C)[nH]c3=O)c12)-c1ccc(nc1)-n1ccn(CC(C)(F)F)cc1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C36H38F2N6O4S/c1-6-9-36(10-11-36)49(47,48)44-21-24(3)32-28(33(45)40-20-29-23(2)16-25(4)41-34(29)46)17-27(18-30(32)44)26-7-8-31(39-19-26)43-14-12-42(13-15-43)22-35(5,37)38/h6-8,12-19,21H,1,9-11,20,22H2,2-5H3,(H,40,45)(H,41,46)
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n/an/a 35n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464533
PNG
(US10793549, Compound G-19)
Show SMILES CCCOc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(cc(O)c12)S(=O)(=O)C1(CC=C)CC1)-c1ccc(nc1)N1CCN(C)CC1
Show InChI InChI=1S/C35H42N6O6S/c1-5-9-35(10-11-35)48(45,46)41-22-29(42)32-26(33(43)37-21-27-30(47-16-6-2)17-23(3)38-34(27)44)18-25(19-28(32)41)24-7-8-31(36-20-24)40-14-12-39(4)13-15-40/h5,7-8,17-20,22,42H,1,6,9-16,21H2,2-4H3,(H,37,43)(H,38,44)
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n/an/a 36n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464548
PNG
(US10793549, Compound G-33)
Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(\C=C\c2ccccn2)cc2n(cc(O)c12)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C30H30N4O6S/c1-4-10-30(11-12-30)41(38,39)34-18-25(35)27-22(15-20(16-24(27)34)8-9-21-7-5-6-13-31-21)28(36)32-17-23-26(40-3)14-19(2)33-29(23)37/h4-9,13-16,18,35H,1,10-12,17H2,2-3H3,(H,32,36)(H,33,37)/b9-8+
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n/an/a 36n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464535
PNG
(US10793549, Compound G-21)
Show SMILES CN(C)Cc1cc(ccc1F)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2c(C)cn(c2c1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C33H37FN4O4S/c1-7-10-33(11-12-33)43(41,42)38-18-21(3)30-26(31(39)35-17-27-20(2)13-22(4)36-32(27)40)15-24(16-29(30)38)23-8-9-28(34)25(14-23)19-37(5)6/h7-9,13-16,18H,1,10-12,17,19H2,2-6H3,(H,35,39)(H,36,40)
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n/an/a 37n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464539
PNG
(US10793549, Compound G-25)
Show SMILES CCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(cc(C)c12)S(=O)(=O)C1(CC=C)CC1)-c1ccc(nc1)-c1cn[nH]c1
Show InChI InChI=1S/C33H34N6O4S/c1-5-9-33(10-11-33)44(42,43)39-19-20(3)30-26(31(40)35-18-27-22(6-2)12-21(4)38-32(27)41)13-24(14-29(30)39)23-7-8-28(34-15-23)25-16-36-37-17-25/h5,7-8,12-17,19H,1,6,9-11,18H2,2-4H3,(H,35,40)(H,36,37)(H,38,41)
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n/an/a 37n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464522
PNG
(US10793549, Compound G-8)
Show SMILES CN(C)c1ccc(cn1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2c(C)cn(c2c1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C31H35N5O4S/c1-7-10-31(11-12-31)41(39,40)36-18-20(3)28-24(29(37)33-17-25-19(2)13-21(4)34-30(25)38)14-23(15-26(28)36)22-8-9-27(32-16-22)35(5)6/h7-9,13-16,18H,1,10-12,17H2,2-6H3,(H,33,37)(H,34,38)
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n/an/a 40n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464524
PNG
(US10793549, Compound G-10)
Show SMILES Cc1cn(c2cc(cc(C(=O)NCc3c(C)cc(C)[nH]c3=O)c12)-c1ccc(nc1)C#N)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C30H29N5O4S/c1-5-8-30(9-10-30)40(38,39)35-17-19(3)27-24(28(36)33-16-25-18(2)11-20(4)34-29(25)37)12-22(13-26(27)35)21-6-7-23(14-31)32-15-21/h5-7,11-13,15,17H,1,8-10,16H2,2-4H3,(H,33,36)(H,34,37)
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n/an/a 41n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464529
PNG
(US10793549, Compound G-15 | US10793549, Compound G...)
Show SMILES CN(C)Cc1ccc(c(F)c1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2c(C)cn(c2c1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C33H37FN4O4S/c1-7-10-33(11-12-33)43(41,42)38-18-21(3)30-26(31(39)35-17-27-20(2)13-22(4)36-32(27)40)15-24(16-29(30)38)25-9-8-23(14-28(25)34)19-37(5)6/h7-9,13-16,18H,1,10-12,17,19H2,2-6H3,(H,35,39)(H,36,40)
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n/an/a 42n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464540
PNG
(US10793549, Compound G-26)
Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(cc(O)c12)S(=O)(=O)C1(CC=C)CC1)-c1ccc(nc1)-c1cncnc1
Show InChI InChI=1S/C32H30N6O6S/c1-4-7-32(8-9-32)45(42,43)38-17-27(39)29-23(30(40)36-16-24-28(44-3)10-19(2)37-31(24)41)11-21(12-26(29)38)20-5-6-25(35-15-20)22-13-33-18-34-14-22/h4-6,10-15,17-18,39H,1,7-9,16H2,2-3H3,(H,36,40)(H,37,41)
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n/an/a 43n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464517
PNG
(US10793549, Compound G-17 | US10793549, Compound G...)
Show SMILES CN(C)Cc1ccc(cc1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2c(C)cn(c2c1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C33H38N4O4S/c1-7-12-33(13-14-33)42(40,41)37-19-22(3)30-27(31(38)34-18-28-21(2)15-23(4)35-32(28)39)16-26(17-29(30)37)25-10-8-24(9-11-25)20-36(5)6/h7-11,15-17,19H,1,12-14,18,20H2,2-6H3,(H,34,38)(H,35,39)
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n/an/a 45n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464571
PNG
(Preparation of 1-(1-allylcyclopropylsulfonyl)-6-br...)
Show SMILES CN1CCN(CC1)c1ccc(cn1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2ccn(c2c1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C33H38N6O4S/c1-5-9-33(10-11-33)44(42,43)39-12-8-26-27(31(40)35-21-28-22(2)17-23(3)36-32(28)41)18-25(19-29(26)39)24-6-7-30(34-20-24)38-15-13-37(4)14-16-38/h5-8,12,17-20H,1,9-11,13-16,21H2,2-4H3,(H,35,40)(H,36,41)
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n/an/a 52n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464526
PNG
(US10793549, Compound G-12)
Show SMILES Cc1cn(c2cc(cc(C(=O)NCc3c(C)cc(C)[nH]c3=O)c12)-c1ccc(nc1)N1CCOCC1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C33H37N5O5S/c1-5-8-33(9-10-33)44(41,42)38-20-22(3)30-26(31(39)35-19-27-21(2)15-23(4)36-32(27)40)16-25(17-28(30)38)24-6-7-29(34-18-24)37-11-13-43-14-12-37/h5-7,15-18,20H,1,8-14,19H2,2-4H3,(H,35,39)(H,36,40)
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n/an/a 58n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464573
PNG
(US10793549, Compound G-74)
Show SMILES CN(C)Cn1ccn(cc1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2c(C)cn(c2c1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C31H38N6O4S/c1-7-8-31(9-10-31)42(40,41)37-19-22(3)28-25(29(38)32-18-26-21(2)15-23(4)33-30(26)39)16-24(17-27(28)37)36-13-11-35(12-14-36)20-34(5)6/h7,11-17,19H,1,8-10,18,20H2,2-6H3,(H,32,38)(H,33,39)
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n/an/a 94n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464579
PNG
(US10793549, Compound G-80)
Show SMILES CN1CCN(CC1)c1ccc(cn1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2c(C)nn(c2c1)S(=O)(=O)CCC=C
Show InChI InChI=1S/C31H37N7O4S/c1-6-7-14-43(41,42)38-27-17-24(23-8-9-28(32-18-23)37-12-10-36(5)11-13-37)16-25(29(27)22(4)35-38)30(39)33-19-26-20(2)15-21(3)34-31(26)40/h6,8-9,15-18H,1,7,10-14,19H2,2-5H3,(H,33,39)(H,34,40)
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n/an/a 145n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464576
PNG
(US10793549, Compound G-77)
Show SMILES CC1CN(c2cc(cc(C(=O)NCc3c(C)cc(C)[nH]c3=O)c12)-c1ccc(nc1)N1CCN(C)CC1)S(=O)(=O)C1(CC=C)CC1
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n/an/a 147n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464572
PNG
(Preparation of N-((4, 6-dimethyl-2-oxo-1, 2-dihydr...)
Show SMILES CC(C)S(=O)(=O)N1CCc2c1cc(cc2C(=O)NCc1c(C)cc(C)[nH]c1=O)-c1ccc(nc1)N1CCN(C)CC1
Show InChI InChI=1S/C30H38N6O4S/c1-19(2)41(39,40)36-9-8-24-25(29(37)32-18-26-20(3)14-21(4)33-30(26)38)15-23(16-27(24)36)22-6-7-28(31-17-22)35-12-10-34(5)11-13-35/h6-7,14-17,19H,8-13,18H2,1-5H3,(H,32,37)(H,33,38)
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n/an/a 160n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464580
PNG
(US10793549, Compound G-81)
Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(cc(C)c12)S(=O)(=O)CCC#C)-c1ccc(nc1)N1CCN(C)CC1
Show InChI InChI=1S/C32H36N6O5S/c1-6-7-14-44(41,42)38-20-21(2)30-25(31(39)34-19-26-28(43-5)15-22(3)35-32(26)40)16-24(17-27(30)38)23-8-9-29(33-18-23)37-12-10-36(4)11-13-37/h1,8-9,15-18,20H,7,10-14,19H2,2-5H3,(H,34,39)(H,35,40)
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n/an/a 196n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464574
PNG
(US10793549, Compound G-75)
Show SMILES CC1CN(c2cc(cc(C(=O)NCc3c(C)cc(C)[nH]c3=O)c12)-c1ccc(CN(C)C)cc1)S(=O)(=O)C1(CC=C)CC1
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n/an/a 280n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464575
PNG
(US10793549, Compound G-76)
Show SMILES CN1CCN(CC1)c1ccc(cn1)-c1cc2N(CCc2c(c1)C(=O)NCc1c(C)cc(C)[nH]c1=O)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C33H40N6O4S/c1-5-9-33(10-11-33)44(42,43)39-12-8-26-27(31(40)35-21-28-22(2)17-23(3)36-32(28)41)18-25(19-29(26)39)24-6-7-30(34-20-24)38-15-13-37(4)14-16-38/h5-7,17-20H,1,8-16,21H2,2-4H3,(H,35,40)(H,36,41)
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n/an/a 460n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464578
PNG
(US10793549, Compound G-79)
Show SMILES CN1CCN(CC1)c1ccc(cn1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2c(C)nn(c2c1)S(=O)(=O)C1(CC=C)CC1
Show InChI InChI=1S/C33H39N7O4S/c1-6-9-33(10-11-33)45(43,44)40-28-18-25(24-7-8-29(34-19-24)39-14-12-38(5)13-15-39)17-26(30(28)23(4)37-40)31(41)35-20-27-21(2)16-22(3)36-32(27)42/h6-8,16-19H,1,9-15,20H2,2-5H3,(H,35,41)(H,36,42)
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n/an/a 585n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
PRC2 (EZH2-Y641F)


(Homo sapiens (Human))
BDBM464577
PNG
(US10793549, Compound G-78)
Show SMILES CN1CCN(CC1)c1ccc(cn1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2c(nn(c2c1)S(=O)(=O)C1(CC=C)CC1)C(F)F
Show InChI InChI=1S/C33H37F2N7O4S/c1-5-8-33(9-10-33)47(45,46)42-26-17-23(22-6-7-27(36-18-22)41-13-11-40(4)12-14-41)16-24(28(26)29(39-42)30(34)35)31(43)37-19-25-20(2)15-21(3)38-32(25)44/h5-7,15-18,30H,1,8-14,19H2,2-4H3,(H,37,43)(H,38,44)
PDB

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n/an/a 1.42E+3n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...


US Patent US10793549 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%