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Patent code US10793556

Compile Data Set for Download or QSAR
Found 178 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nociceptin receptor


(Homo sapiens (Human))
BDBM464662
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)N3CCCS3(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H44N4O4S/c1-25(2,32-18-9-19-37(32,35)36)20-30-21-26(31(24(30)33)22-27(34)12-8-13-27)14-16-28(17-15-26,29(3)4)23-10-6-5-7-11-23/h5-7,10-11,34H,8-9,12-22H2,1-4H3/t26-,28+
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0.400n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464637
PNG
(CIS-8-Dimethylamino-1,3-bis(2-methylsulfonyl-ethyl...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3CCN(CC3)c3cncnc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H42N6O/c1-33(2)30(26-6-4-3-5-7-26)14-12-29(13-15-30)22-35(28(37)36(29)21-24-8-9-24)20-25-10-16-34(17-11-25)27-18-31-23-32-19-27/h3-7,18-19,23-25H,8-17,20-22H2,1-2H3/t29-,30+
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1n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464643
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-3-[2-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H43N3O4S/c1-29(2)28(24-9-4-3-5-10-24)13-11-26(12-14-28)22-30(25(32)31(26)21-23-7-6-8-23)18-15-27(33)16-19-36(34,35)20-17-27/h3-5,9-10,23,33H,6-8,11-22H2,1-2H3/t26-,28+
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1n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464589
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-(2-met...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCS(C)(=O)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C24H37N3O3S/c1-25(2)24(21-10-5-4-6-11-21)14-12-23(13-15-24)19-26(16-17-31(3,29)30)22(28)27(23)18-20-8-7-9-20/h4-6,10-11,20H,7-9,12-19H2,1-3H3/t23-,24+
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1.10n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464596
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-methyl...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(C)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C22H33N3O/c1-23(2)22(19-10-5-4-6-11-19)14-12-21(13-15-22)17-24(3)20(26)25(21)16-18-8-7-9-18/h4-6,10-11,18H,7-9,12-17H2,1-3H3/t21-,22+
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1.30n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464592
PNG
(CIS-4-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCCC#N)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H36N4O/c1-27(2)25(22-11-4-3-5-12-22)15-13-24(14-16-25)20-28(18-7-6-17-26)23(30)29(24)19-21-9-8-10-21/h3-5,11-12,21H,6-10,13-16,18-20H2,1-2H3/t24-,25+
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1.60n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464594
PNG
(CIS-3-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C#N)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H38N4O/c1-24(2,18-27)19-29-20-25(30(23(29)31)17-21-9-8-10-21)13-15-26(16-14-25,28(3)4)22-11-6-5-7-12-22/h5-7,11-12,21H,8-10,13-17,19-20H2,1-4H3/t25-,26+
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2.10n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464581
PNG
(CIS-4-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCCC(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H38N4O2/c1-27(2)25(21-10-4-3-5-11-21)15-13-24(14-16-25)19-28(17-7-12-22(26)30)23(31)29(24)18-20-8-6-9-20/h3-5,10-11,20H,6-9,12-19H2,1-2H3,(H2,26,30)/t24-,25+
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2.30n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464587
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-(2-met...)
Show SMILES COCCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C24H37N3O2/c1-25(2)24(21-10-5-4-6-11-21)14-12-23(13-15-24)19-26(16-17-29-3)22(28)27(23)18-20-8-7-9-20/h4-6,10-11,20H,7-9,12-19H2,1-3H3/t23-,24+
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2.60n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464605
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-3-(2-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O4S/c1-28(2)27(23-7-4-3-5-8-23)15-13-25(14-16-27)20-29(19-22-9-17-35(33,34)18-10-22)24(31)30(25)21-26(32)11-6-12-26/h3-5,7-8,22,32H,6,9-21H2,1-2H3/t25-,27+
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GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464626
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(C3CCN(CC3)c3cncnc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H40N6O/c1-32(2)29(24-6-4-3-5-7-24)14-12-28(13-15-29)21-34(27(36)35(28)20-23-8-9-23)25-10-16-33(17-11-25)26-18-30-22-31-19-26/h3-7,18-19,22-23,25H,8-17,20-21H2,1-2H3/t28-,29+
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GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464620
PNG
(CIS-3-(1-Benzoyl-piperidin-4-yl)-1-(cyclopropyl-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(C3CCN(CC3)C(=O)c3ccncc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C31H41N5O2/c1-33(2)31(26-6-4-3-5-7-26)16-14-30(15-17-31)23-35(29(38)36(30)22-24-8-9-24)27-12-20-34(21-13-27)28(37)25-10-18-32-19-11-25/h3-7,10-11,18-19,24,27H,8-9,12-17,20-23H2,1-2H3/t30-,31+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464656
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)NS(C)(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H42N4O4S/c1-23(2,27-35(5,33)34)18-29-19-24(30(22(29)31)20-25(32)12-9-13-25)14-16-26(17-15-24,28(3)4)21-10-7-6-8-11-21/h6-8,10-11,27,32H,9,12-20H2,1-5H3/t24-,26+
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GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464586
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[2-(2-...)
Show SMILES COCCOCCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C26H41N3O3/c1-27(2)26(23-10-5-4-6-11-23)14-12-25(13-15-26)21-28(16-17-32-19-18-31-3)24(30)29(25)20-22-8-7-9-22/h4-6,10-11,22H,7-9,12-21H2,1-3H3/t25-,26+
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GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464611
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O4S/c1-28(2)27(23-9-4-3-5-10-23)13-11-25(12-14-27)20-29(24(31)30(25)19-22-7-6-8-22)21-26(32)15-17-35(33,34)18-16-26/h3-5,9-10,22,32H,6-8,11-21H2,1-2H3/t25-,27+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464611
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O4S/c1-28(2)27(23-9-4-3-5-10-23)13-11-25(12-14-27)20-29(24(31)30(25)19-22-7-6-8-22)21-26(32)15-17-35(33,34)18-16-26/h3-5,9-10,22,32H,6-8,11-21H2,1-2H3/t25-,27+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464631
PNG
(CIS-3-(1-Benzoyl-piperidin-4-yl)-8-dimethylamino-8...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H39N3O4S/c1-27(2)26(22-6-4-3-5-7-22)12-10-24(11-13-26)19-28(23(30)29(24)18-21-8-9-21)20-25(31)14-16-34(32,33)17-15-25/h3-7,21,31H,8-20H2,1-2H3/t24-,26+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464593
PNG
(CIS-4-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CNC(=O)CCCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C26H40N4O2/c1-27-23(31)13-8-18-29-20-25(30(24(29)32)19-21-9-7-10-21)14-16-26(17-15-25,28(2)3)22-11-5-4-6-12-22/h4-6,11-12,21H,7-10,13-20H2,1-3H3,(H,27,31)/t25-,26+
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5.80n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464662
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)N3CCCS3(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H44N4O4S/c1-25(2,32-18-9-19-37(32,35)36)20-30-21-26(31(24(30)33)22-27(34)12-8-13-27)14-16-28(17-15-26,29(3)4)23-10-6-5-7-11-23/h5-7,10-11,34H,8-9,12-22H2,1-4H3/t26-,28+
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6n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464656
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)NS(C)(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H42N4O4S/c1-23(2,27-35(5,33)34)18-29-19-24(30(22(29)31)20-25(32)12-9-13-25)14-16-26(17-15-24,28(3)4)21-10-7-6-8-11-21/h6-8,10-11,27,32H,9,12-20H2,1-5H3/t24-,26+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464643
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-3-[2-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H43N3O4S/c1-29(2)28(24-9-4-3-5-10-24)13-11-26(12-14-28)22-30(25(32)31(26)21-23-7-6-8-23)18-15-27(33)16-19-36(34,35)20-17-27/h3-5,9-10,23,33H,6-8,11-22H2,1-2H3/t26-,28+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464650
PNG
(CIS-8-Dimethylamino-3-(2-methylsulfonyl-ethyl)-1-(...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H43N3O5S/c1-29(2)28(23-7-4-3-5-8-23)13-11-25(12-14-28)21-30(24(32)31(25)22-27(34)9-6-10-27)18-15-26(33)16-19-37(35,36)20-17-26/h3-5,7-8,33-34H,6,9-22H2,1-2H3/t25-,28+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464656
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)NS(C)(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H42N4O4S/c1-23(2,27-35(5,33)34)18-29-19-24(30(22(29)31)20-25(32)12-9-13-25)14-16-26(17-15-24,28(3)4)21-10-7-6-8-11-21/h6-8,10-11,27,32H,9,12-20H2,1-5H3/t24-,26+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464588
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[2-[2-...)
Show SMILES COCCOCCOCCOCCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C30H49N3O5/c1-31(2)30(27-10-5-4-6-11-27)14-12-29(13-15-30)25-32(28(34)33(29)24-26-8-7-9-26)16-17-36-20-21-38-23-22-37-19-18-35-3/h4-6,10-11,26H,7-9,12-25H2,1-3H3/t29-,30+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464583
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[2-[2-...)
Show SMILES COCCOCCOCCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C28H45N3O4/c1-29(2)28(25-10-5-4-6-11-25)14-12-27(13-15-28)23-30(16-17-34-20-21-35-19-18-33-3)26(32)31(27)22-24-8-7-9-24/h4-6,10-11,24H,7-9,12-23H2,1-3H3/t27-,28+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464615
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O5S/c1-28(2)27(22-7-4-3-5-8-22)13-11-24(12-14-27)19-29(20-26(33)15-17-36(34,35)18-16-26)23(31)30(24)21-25(32)9-6-10-25/h3-5,7-8,32-33H,6,9-21H2,1-2H3/t24-,27+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464605
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-3-(2-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O4S/c1-28(2)27(23-7-4-3-5-8-23)15-13-25(14-16-27)20-29(19-22-9-17-35(33,34)18-10-22)24(31)30(25)21-26(32)11-6-12-26/h3-5,7-8,22,32H,6,9-21H2,1-2H3/t25-,27+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464667
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-(3-fl...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(C3CCN(CC3)c3cncnc3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H42N6O2/c1-33(2)30(24-7-4-3-5-8-24)15-13-28(14-16-30)21-35(27(37)36(28)22-29(38)11-6-12-29)25-9-17-34(18-10-25)26-19-31-23-32-20-26/h3-5,7-8,19-20,23,25,38H,6,9-18,21-22H2,1-2H3/t28-,30+
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Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464590
PNG
(CIS-1-(Cyclobutyl-methyl)-8-methylamino-3-(2-methy...)
Show SMILES CN[C@]1(CC[C@]2(CN(CCS(C)(=O)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C23H35N3O3S/c1-24-23(20-9-4-3-5-10-20)13-11-22(12-14-23)18-25(15-16-30(2,28)29)21(27)26(22)17-19-7-6-8-19/h3-5,9-10,19,24H,6-8,11-18H2,1-2H3/t22-,23+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464675
PNG
(CIS-3-[1-(Cyclopropyl-methyl)-8-dimethylamino-2-ox...)
Show SMILES CN(C)[C@@]1(CC[C@]2(CN(CC(C)(C)C#N)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H36N4O/c1-23(2,17-26)18-28-19-24(29(22(28)30)16-20-10-11-20)12-14-25(15-13-24,27(3)4)21-8-6-5-7-9-21/h5-9,20H,10-16,18-19H2,1-4H3/t24-,25-
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464656
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)NS(C)(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H42N4O4S/c1-23(2,27-35(5,33)34)18-29-19-24(30(22(29)31)20-25(32)12-9-13-25)14-16-26(17-15-24,28(3)4)21-10-7-6-8-11-21/h6-8,10-11,27,32H,9,12-20H2,1-5H3/t24-,26+
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Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464650
PNG
(CIS-8-Dimethylamino-3-(2-methylsulfonyl-ethyl)-1-(...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H43N3O5S/c1-29(2)28(23-7-4-3-5-8-23)13-11-25(12-14-28)21-30(24(32)31(25)22-27(34)9-6-10-27)18-15-26(33)16-19-37(35,36)20-17-26/h3-5,7-8,33-34H,6,9-22H2,1-2H3/t25-,28+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464650
PNG
(CIS-8-Dimethylamino-3-(2-methylsulfonyl-ethyl)-1-(...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H43N3O5S/c1-29(2)28(23-7-4-3-5-8-23)13-11-25(12-14-28)21-30(24(32)31(25)22-27(34)9-6-10-27)18-15-26(33)16-19-37(35,36)20-17-26/h3-5,7-8,33-34H,6,9-22H2,1-2H3/t25-,28+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464626
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(C3CCN(CC3)c3cncnc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H40N6O/c1-32(2)29(24-6-4-3-5-7-24)14-12-28(13-15-29)21-34(27(36)35(28)20-23-8-9-23)25-10-16-33(17-11-25)26-18-30-22-31-19-26/h3-7,18-19,22-23,25H,8-17,20-21H2,1-2H3/t28-,29+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464643
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-3-[2-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H43N3O4S/c1-29(2)28(24-9-4-3-5-10-24)13-11-26(12-14-28)22-30(25(32)31(26)21-23-7-6-8-23)18-15-27(33)16-19-36(34,35)20-17-27/h3-5,9-10,23,33H,6-8,11-22H2,1-2H3/t26-,28+
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Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464620
PNG
(CIS-3-(1-Benzoyl-piperidin-4-yl)-1-(cyclopropyl-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(C3CCN(CC3)C(=O)c3ccncc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C31H41N5O2/c1-33(2)31(26-6-4-3-5-7-26)16-14-30(15-17-31)23-35(29(38)36(30)22-24-8-9-24)27-12-20-34(21-13-27)28(37)25-10-18-32-19-11-25/h3-7,10-11,18-19,24,27H,8-9,12-17,20-23H2,1-2H3/t30-,31+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464611
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O4S/c1-28(2)27(23-9-4-3-5-10-23)13-11-25(12-14-27)20-29(24(31)30(25)19-22-7-6-8-22)21-26(32)15-17-35(33,34)18-16-26/h3-5,9-10,22,32H,6-8,11-21H2,1-2H3/t25-,27+
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Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464605
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-3-(2-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O4S/c1-28(2)27(23-7-4-3-5-8-23)15-13-25(14-16-27)20-29(19-22-9-17-35(33,34)18-10-22)24(31)30(25)21-26(32)11-6-12-26/h3-5,7-8,22,32H,6,9-21H2,1-2H3/t25-,27+
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Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464656
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)NS(C)(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H42N4O4S/c1-23(2,27-35(5,33)34)18-29-19-24(30(22(29)31)20-25(32)12-9-13-25)14-16-26(17-15-24,28(3)4)21-10-7-6-8-11-21/h6-8,10-11,27,32H,9,12-20H2,1-5H3/t24-,26+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464643
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-3-[2-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H43N3O4S/c1-29(2)28(24-9-4-3-5-10-24)13-11-26(12-14-28)22-30(25(32)31(26)21-23-7-6-8-23)18-15-27(33)16-19-36(34,35)20-17-27/h3-5,9-10,23,33H,6-8,11-22H2,1-2H3/t26-,28+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464637
PNG
(CIS-8-Dimethylamino-1,3-bis(2-methylsulfonyl-ethyl...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3CCN(CC3)c3cncnc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H42N6O/c1-33(2)30(26-6-4-3-5-7-26)14-12-29(13-15-30)22-35(28(37)36(29)21-24-8-9-24)20-25-10-16-34(17-11-25)27-18-31-23-32-19-27/h3-7,18-19,23-25H,8-17,20-22H2,1-2H3/t29-,30+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464591
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCS(C)(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C24H37N3O4S/c1-25(2)24(20-8-5-4-6-9-20)14-12-22(13-15-24)18-26(16-17-32(3,30)31)21(28)27(22)19-23(29)10-7-11-23/h4-6,8-9,29H,7,10-19H2,1-3H3/t22-,24+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464637
PNG
(CIS-8-Dimethylamino-1,3-bis(2-methylsulfonyl-ethyl...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3CCN(CC3)c3cncnc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H42N6O/c1-33(2)30(26-6-4-3-5-7-26)14-12-29(13-15-30)22-35(28(37)36(29)21-24-8-9-24)20-25-10-16-34(17-11-25)27-18-31-23-32-19-27/h3-7,18-19,23-25H,8-17,20-22H2,1-2H3/t29-,30+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464615
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O5S/c1-28(2)27(22-7-4-3-5-8-22)13-11-24(12-14-27)19-29(20-26(33)15-17-36(34,35)18-16-26)23(31)30(24)21-25(32)9-6-10-25/h3-5,7-8,32-33H,6,9-21H2,1-2H3/t24-,27+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464626
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(C3CCN(CC3)c3cncnc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H40N6O/c1-32(2)29(24-6-4-3-5-7-24)14-12-28(13-15-29)21-34(27(36)35(28)20-23-8-9-23)25-10-16-33(17-11-25)26-18-30-22-31-19-26/h3-7,18-19,22-23,25H,8-17,20-21H2,1-2H3/t28-,29+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464631
PNG
(CIS-3-(1-Benzoyl-piperidin-4-yl)-8-dimethylamino-8...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H39N3O4S/c1-27(2)26(22-6-4-3-5-7-22)12-10-24(11-13-26)19-28(23(30)29(24)18-21-8-9-21)20-25(31)14-16-34(32,33)17-15-25/h3-7,21,31H,8-20H2,1-2H3/t24-,26+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464662
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)N3CCCS3(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H44N4O4S/c1-25(2,32-18-9-19-37(32,35)36)20-30-21-26(31(24(30)33)22-27(34)12-8-13-27)14-16-28(17-15-26,29(3)4)23-10-6-5-7-11-23/h5-7,10-11,34H,8-9,12-22H2,1-4H3/t26-,28+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464586
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[2-(2-...)
Show SMILES COCCOCCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C26H41N3O3/c1-27(2)26(23-10-5-4-6-11-23)14-12-25(13-15-26)21-28(16-17-32-19-18-31-3)24(30)29(25)20-22-8-7-9-22/h4-6,10-11,22H,7-9,12-21H2,1-3H3/t25-,26+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464662
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)N3CCCS3(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H44N4O4S/c1-25(2,32-18-9-19-37(32,35)36)20-30-21-26(31(24(30)33)22-27(34)12-8-13-27)14-16-28(17-15-26,29(3)4)23-10-6-5-7-11-23/h5-7,10-11,34H,8-9,12-22H2,1-4H3/t26-,28+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464662
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)N3CCCS3(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H44N4O4S/c1-25(2,32-18-9-19-37(32,35)36)20-30-21-26(31(24(30)33)22-27(34)12-8-13-27)14-16-28(17-15-26,29(3)4)23-10-6-5-7-11-23/h5-7,10-11,34H,8-9,12-22H2,1-4H3/t26-,28+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464643
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-3-[2-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H43N3O4S/c1-29(2)28(24-9-4-3-5-10-24)13-11-26(12-14-28)22-30(25(32)31(26)21-23-7-6-8-23)18-15-27(33)16-19-36(34,35)20-17-27/h3-5,9-10,23,33H,6-8,11-22H2,1-2H3/t26-,28+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464615
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O5S/c1-28(2)27(22-7-4-3-5-8-22)13-11-24(12-14-27)19-29(20-26(33)15-17-36(34,35)18-16-26)23(31)30(24)21-25(32)9-6-10-25/h3-5,7-8,32-33H,6,9-21H2,1-2H3/t24-,27+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464585
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[2-[2-...)
Show SMILES COCCOCCOCCOCCOCCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C32H53N3O6/c1-33(2)32(29-10-5-4-6-11-29)14-12-31(13-15-32)27-34(30(36)35(31)26-28-8-7-9-28)16-17-38-20-21-40-24-25-41-23-22-39-19-18-37-3/h4-6,10-11,28H,7-9,12-27H2,1-3H3/t31-,32+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464620
PNG
(CIS-3-(1-Benzoyl-piperidin-4-yl)-1-(cyclopropyl-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(C3CCN(CC3)C(=O)c3ccncc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C31H41N5O2/c1-33(2)31(26-6-4-3-5-7-26)16-14-30(15-17-31)23-35(29(38)36(30)22-24-8-9-24)27-12-20-34(21-13-27)28(37)25-10-18-32-19-11-25/h3-7,10-11,18-19,24,27H,8-9,12-17,20-23H2,1-2H3/t30-,31+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464611
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O4S/c1-28(2)27(23-9-4-3-5-10-23)13-11-25(12-14-27)20-29(24(31)30(25)19-22-7-6-8-22)21-26(32)15-17-35(33,34)18-16-26/h3-5,9-10,22,32H,6-8,11-21H2,1-2H3/t25-,27+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464615
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O5S/c1-28(2)27(22-7-4-3-5-8-22)13-11-24(12-14-27)19-29(20-26(33)15-17-36(34,35)18-16-26)23(31)30(24)21-25(32)9-6-10-25/h3-5,7-8,32-33H,6,9-21H2,1-2H3/t24-,27+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464596
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-methyl...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(C)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C22H33N3O/c1-23(2)22(19-10-5-4-6-11-19)14-12-21(13-15-22)17-24(3)20(26)25(21)16-18-8-7-9-18/h4-6,10-11,18H,7-9,12-17H2,1-3H3/t21-,22+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464620
PNG
(CIS-3-(1-Benzoyl-piperidin-4-yl)-1-(cyclopropyl-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(C3CCN(CC3)C(=O)c3ccncc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C31H41N5O2/c1-33(2)31(26-6-4-3-5-7-26)16-14-30(15-17-31)23-35(29(38)36(30)22-24-8-9-24)27-12-20-34(21-13-27)28(37)25-10-18-32-19-11-25/h3-7,10-11,18-19,24,27H,8-9,12-17,20-23H2,1-2H3/t30-,31+
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21n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464667
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-(3-fl...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(C3CCN(CC3)c3cncnc3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H42N6O2/c1-33(2)30(24-7-4-3-5-8-24)15-13-28(14-16-30)21-35(27(37)36(28)22-29(38)11-6-12-29)25-9-17-34(18-10-25)26-19-31-23-32-20-26/h3-5,7-8,19-20,23,25,38H,6,9-18,21-22H2,1-2H3/t28-,30+
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23n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464675
PNG
(CIS-3-[1-(Cyclopropyl-methyl)-8-dimethylamino-2-ox...)
Show SMILES CN(C)[C@@]1(CC[C@]2(CN(CC(C)(C)C#N)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H36N4O/c1-23(2,17-26)18-28-19-24(29(22(28)30)16-20-10-11-20)12-14-25(15-13-24,27(3)4)21-8-6-5-7-9-21/h5-9,20H,10-16,18-19H2,1-4H3/t24-,25-
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24n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464598
PNG
(CIS-3-[1-[(1-Hydroxy-cyclobutyl)-methyl]-8-methyla...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCN3CCOCC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H42N4O3/c1-28(2)27(23-7-4-3-5-8-23)13-11-25(12-14-27)21-30(16-15-29-17-19-34-20-18-29)24(32)31(25)22-26(33)9-6-10-26/h3-5,7-8,33H,6,9-22H2,1-2H3/t25-,27+
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26n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464626
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(C3CCN(CC3)c3cncnc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H40N6O/c1-32(2)29(24-6-4-3-5-7-24)14-12-28(13-15-29)21-34(27(36)35(28)20-23-8-9-23)25-10-16-33(17-11-25)26-18-30-22-31-19-26/h3-7,18-19,22-23,25H,8-17,20-21H2,1-2H3/t28-,29+
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26n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464631
PNG
(CIS-3-(1-Benzoyl-piperidin-4-yl)-8-dimethylamino-8...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H39N3O4S/c1-27(2)26(22-6-4-3-5-7-22)12-10-24(11-13-26)19-28(23(30)29(24)18-21-8-9-21)20-25(31)14-16-34(32,33)17-15-25/h3-7,21,31H,8-20H2,1-2H3/t24-,26+
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27n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464582
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[2-[2-...)
Show SMILES COCCOCCOCCOCCOCCOCCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C34H57N3O7/c1-35(2)34(31-10-5-4-6-11-31)14-12-33(13-15-34)29-36(32(38)37(33)28-30-8-7-9-30)16-17-40-20-21-42-24-25-44-27-26-43-23-22-41-19-18-39-3/h4-6,10-11,30H,7-9,12-29H2,1-3H3/t33-,34+
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28n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464620
PNG
(CIS-3-(1-Benzoyl-piperidin-4-yl)-1-(cyclopropyl-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(C3CCN(CC3)C(=O)c3ccncc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C31H41N5O2/c1-33(2)31(26-6-4-3-5-7-26)16-14-30(15-17-31)23-35(29(38)36(30)22-24-8-9-24)27-12-20-34(21-13-27)28(37)25-10-18-32-19-11-25/h3-7,10-11,18-19,24,27H,8-9,12-17,20-23H2,1-2H3/t30-,31+
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34n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464669
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1cccc(F)c1
Show InChI InChI=1S/C27H40FN3O5S/c1-29(2)27(21-5-3-6-22(28)17-21)11-9-24(10-12-27)18-30(19-26(34)13-15-37(35,36)16-14-26)23(32)31(24)20-25(33)7-4-8-25/h3,5-6,17,33-34H,4,7-16,18-20H2,1-2H3/t24-,27+
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36n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464589
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-(2-met...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCS(C)(=O)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C24H37N3O3S/c1-25(2)24(21-10-5-4-6-11-21)14-12-23(13-15-24)19-26(16-17-31(3,29)30)22(28)27(23)18-20-8-7-9-20/h4-6,10-11,20H,7-9,12-19H2,1-3H3/t23-,24+
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37.4n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464643
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-3-[2-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H43N3O4S/c1-29(2)28(24-9-4-3-5-10-24)13-11-26(12-14-28)22-30(25(32)31(26)21-23-7-6-8-23)18-15-27(33)16-19-36(34,35)20-17-27/h3-5,9-10,23,33H,6-8,11-22H2,1-2H3/t26-,28+
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39n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464583
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[2-[2-...)
Show SMILES COCCOCCOCCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C28H45N3O4/c1-29(2)28(25-10-5-4-6-11-25)14-12-27(13-15-28)23-30(16-17-34-20-21-35-19-18-33-3)26(32)31(27)22-24-8-7-9-24/h4-6,10-11,24H,7-9,12-23H2,1-3H3/t27-,28+
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39.5n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464637
PNG
(CIS-8-Dimethylamino-1,3-bis(2-methylsulfonyl-ethyl...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3CCN(CC3)c3cncnc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H42N6O/c1-33(2)30(26-6-4-3-5-7-26)14-12-29(13-15-30)22-35(28(37)36(29)21-24-8-9-24)20-25-10-16-34(17-11-25)27-18-31-23-32-19-27/h3-7,18-19,23-25H,8-17,20-22H2,1-2H3/t29-,30+
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40n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464593
PNG
(CIS-4-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CNC(=O)CCCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C26H40N4O2/c1-27-23(31)13-8-18-29-20-25(30(24(29)32)19-21-9-7-10-21)14-16-26(17-15-25,28(2)3)22-11-5-4-6-12-22/h4-6,11-12,21H,7-10,13-20H2,1-3H3,(H,27,31)/t25-,26+
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40.5n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464584
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[2-[2-...)
Show SMILES COCCOCCOCCOCCOCCOCCOCCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C36H61N3O8/c1-37(2)36(33-10-5-4-6-11-33)14-12-35(13-15-36)31-38(34(40)39(35)30-32-8-7-9-32)16-17-42-20-21-44-24-25-46-28-29-47-27-26-45-23-22-43-19-18-41-3/h4-6,10-11,32H,7-9,12-31H2,1-3H3/t35-,36+
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44n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464595
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[2-[2-...)
Show SMILES COCCOCCOCCOCCOCCOCCOCCOCCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C38H65N3O9/c1-39(2)38(35-10-5-4-6-11-35)14-12-37(13-15-38)33-40(36(42)41(37)32-34-8-7-9-34)16-17-44-20-21-46-24-25-48-28-29-50-31-30-49-27-26-47-23-22-45-19-18-43-3/h4-6,10-11,34H,7-9,12-33H2,1-3H3/t37-,38+
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45n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464615
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O5S/c1-28(2)27(22-7-4-3-5-8-22)13-11-24(12-14-27)19-29(20-26(33)15-17-36(34,35)18-16-26)23(31)30(24)21-25(32)9-6-10-25/h3-5,7-8,32-33H,6,9-21H2,1-2H3/t24-,27+
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46n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464626
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(C3CCN(CC3)c3cncnc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H40N6O/c1-32(2)29(24-6-4-3-5-7-24)14-12-28(13-15-29)21-34(27(36)35(28)20-23-8-9-23)25-10-16-33(17-11-25)26-18-30-22-31-19-26/h3-7,18-19,22-23,25H,8-17,20-21H2,1-2H3/t28-,29+
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54n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464598
PNG
(CIS-3-[1-[(1-Hydroxy-cyclobutyl)-methyl]-8-methyla...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCN3CCOCC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H42N4O3/c1-28(2)27(23-7-4-3-5-8-23)13-11-25(12-14-27)21-30(16-15-29-17-19-34-20-18-29)24(32)31(25)22-26(33)9-6-10-26/h3-5,7-8,33H,6,9-22H2,1-2H3/t25-,27+
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57n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464587
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-(2-met...)
Show SMILES COCCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C24H37N3O2/c1-25(2)24(21-10-5-4-6-11-21)14-12-23(13-15-24)19-26(16-17-29-3)22(28)27(23)18-20-8-7-9-20/h4-6,10-11,20H,7-9,12-19H2,1-3H3/t23-,24+
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58n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464637
PNG
(CIS-8-Dimethylamino-1,3-bis(2-methylsulfonyl-ethyl...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3CCN(CC3)c3cncnc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H42N6O/c1-33(2)30(26-6-4-3-5-7-26)14-12-29(13-15-30)22-35(28(37)36(29)21-24-8-9-24)20-25-10-16-34(17-11-25)27-18-31-23-32-19-27/h3-7,18-19,23-25H,8-17,20-22H2,1-2H3/t29-,30+
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63n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464662
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)N3CCCS3(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H44N4O4S/c1-25(2,32-18-9-19-37(32,35)36)20-30-21-26(31(24(30)33)22-27(34)12-8-13-27)14-16-28(17-15-26,29(3)4)23-10-6-5-7-11-23/h5-7,10-11,34H,8-9,12-22H2,1-4H3/t26-,28+
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64n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464585
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[2-[2-...)
Show SMILES COCCOCCOCCOCCOCCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C32H53N3O6/c1-33(2)32(29-10-5-4-6-11-29)14-12-31(13-15-32)27-34(30(36)35(31)26-28-8-7-9-28)16-17-38-20-21-40-24-25-41-23-22-39-19-18-37-3/h4-6,10-11,28H,7-9,12-27H2,1-3H3/t31-,32+
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64.5n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464605
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-3-(2-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O4S/c1-28(2)27(23-7-4-3-5-8-23)15-13-25(14-16-27)20-29(19-22-9-17-35(33,34)18-10-22)24(31)30(25)21-26(32)11-6-12-26/h3-5,7-8,22,32H,6,9-21H2,1-2H3/t25-,27+
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69n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464605
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-3-(2-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O4S/c1-28(2)27(23-7-4-3-5-8-23)15-13-25(14-16-27)20-29(19-22-9-17-35(33,34)18-10-22)24(31)30(25)21-26(32)11-6-12-26/h3-5,7-8,22,32H,6,9-21H2,1-2H3/t25-,27+
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69n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464588
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[2-[2-...)
Show SMILES COCCOCCOCCOCCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C30H49N3O5/c1-31(2)30(27-10-5-4-6-11-27)14-12-29(13-15-30)25-32(28(34)33(29)24-26-8-7-9-26)16-17-36-20-21-38-23-22-37-19-18-35-3/h4-6,10-11,26H,7-9,12-25H2,1-3H3/t29-,30+
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69.8n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464650
PNG
(CIS-8-Dimethylamino-3-(2-methylsulfonyl-ethyl)-1-(...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H43N3O5S/c1-29(2)28(23-7-4-3-5-8-23)13-11-25(12-14-28)21-30(24(32)31(25)22-27(34)9-6-10-27)18-15-26(33)16-19-37(35,36)20-17-26/h3-5,7-8,33-34H,6,9-22H2,1-2H3/t25-,28+
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74n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464650
PNG
(CIS-8-Dimethylamino-3-(2-methylsulfonyl-ethyl)-1-(...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H43N3O5S/c1-29(2)28(23-7-4-3-5-8-23)13-11-25(12-14-28)21-30(24(32)31(25)22-27(34)9-6-10-27)18-15-26(33)16-19-37(35,36)20-17-26/h3-5,7-8,33-34H,6,9-22H2,1-2H3/t25-,28+
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75n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464662
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)N3CCCS3(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H44N4O4S/c1-25(2,32-18-9-19-37(32,35)36)20-30-21-26(31(24(30)33)22-27(34)12-8-13-27)14-16-28(17-15-26,29(3)4)23-10-6-5-7-11-23/h5-7,10-11,34H,8-9,12-22H2,1-4H3/t26-,28+
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76n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464581
PNG
(CIS-4-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCCC(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H38N4O2/c1-27(2)25(21-10-4-3-5-11-21)15-13-24(14-16-25)19-28(17-7-12-22(26)30)23(31)29(24)18-20-8-6-9-20/h3-5,10-11,20H,6-9,12-19H2,1-2H3,(H2,26,30)/t24-,25+
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80.5n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464597
PNG
(CIS-1-[(1-Hydroxy-cyclobutyl)-methyl]-8-methylamin...)
Show SMILES CN[C@]1(CC[C@]2(CN(CCS(C)(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C23H35N3O4S/c1-24-23(19-7-4-3-5-8-19)13-11-21(12-14-23)17-25(15-16-31(2,29)30)20(27)26(21)18-22(28)9-6-10-22/h3-5,7-8,24,28H,6,9-18H2,1-2H3/t21-,23+
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83n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464672
PNG
(CIS-3-[8-(Ethyl-methyl-amino)-2-oxo-8-phenyl-1,3-d...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C#N)C(=O)N2CC2(F)CC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H35FN4O/c1-22(2,16-27)17-29-19-24(30(21(29)31)18-23(26)10-11-23)12-14-25(15-13-24,28(3)4)20-8-6-5-7-9-20/h5-9H,10-15,17-19H2,1-4H3/t24-,25+
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84n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464594
PNG
(CIS-3-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C#N)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H38N4O/c1-24(2,18-27)19-29-20-25(30(23(29)31)17-21-9-8-10-21)13-15-26(16-14-25,28(3)4)22-11-6-5-7-12-22/h5-7,11-12,21H,8-10,13-17,19-20H2,1-4H3/t25-,26+
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84n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464590
PNG
(CIS-1-(Cyclobutyl-methyl)-8-methylamino-3-(2-methy...)
Show SMILES CN[C@]1(CC[C@]2(CN(CCS(C)(=O)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C23H35N3O3S/c1-24-23(20-9-4-3-5-10-20)13-11-22(12-14-23)18-25(15-16-30(2,28)29)21(27)26(22)17-19-7-6-8-19/h3-5,9-10,19,24H,6-8,11-18H2,1-2H3/t22-,23+
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87n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464669
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1cccc(F)c1
Show InChI InChI=1S/C27H40FN3O5S/c1-29(2)27(21-5-3-6-22(28)17-21)11-9-24(10-12-27)18-30(19-26(34)13-15-37(35,36)16-14-26)23(32)31(24)20-25(33)7-4-8-25/h3,5-6,17,33-34H,4,7-16,18-20H2,1-2H3/t24-,27+
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96n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464592
PNG
(CIS-4-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCCC#N)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H36N4O/c1-27(2)25(22-11-4-3-5-12-22)15-13-24(14-16-25)20-28(18-7-6-17-26)23(30)29(24)19-21-9-8-10-21/h3-5,11-12,21H,6-10,13-16,18-20H2,1-2H3/t24-,25+
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99.7n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464669
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1cccc(F)c1
Show InChI InChI=1S/C27H40FN3O5S/c1-29(2)27(21-5-3-6-22(28)17-21)11-9-24(10-12-27)18-30(19-26(34)13-15-37(35,36)16-14-26)23(32)31(24)20-25(33)7-4-8-25/h3,5-6,17,33-34H,4,7-16,18-20H2,1-2H3/t24-,27+
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114n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464656
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)NS(C)(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H42N4O4S/c1-23(2,27-35(5,33)34)18-29-19-24(30(22(29)31)20-25(32)12-9-13-25)14-16-26(17-15-24,28(3)4)21-10-7-6-8-11-21/h6-8,10-11,27,32H,9,12-20H2,1-5H3/t24-,26+
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118n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464602
PNG
(CIS-3-Acetyl-8-dimethylamino-8-phenyl-1,3-diazaspi...)
Show SMILES COC(=O)CCCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C26H39N3O3/c1-27(2)26(22-11-5-4-6-12-22)16-14-25(15-17-26)20-28(18-8-13-23(30)32-3)24(31)29(25)19-21-9-7-10-21/h4-6,11-12,21H,7-10,13-20H2,1-3H3/t25-,26+
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119n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464611
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O4S/c1-28(2)27(23-9-4-3-5-10-23)13-11-25(12-14-27)20-29(24(31)30(25)19-22-7-6-8-22)21-26(32)15-17-35(33,34)18-16-26/h3-5,9-10,22,32H,6-8,11-21H2,1-2H3/t25-,27+
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124n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464611
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O4S/c1-28(2)27(23-9-4-3-5-10-23)13-11-25(12-14-27)20-29(24(31)30(25)19-22-7-6-8-22)21-26(32)15-17-35(33,34)18-16-26/h3-5,9-10,22,32H,6-8,11-21H2,1-2H3/t25-,27+
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125n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464650
PNG
(CIS-8-Dimethylamino-3-(2-methylsulfonyl-ethyl)-1-(...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H43N3O5S/c1-29(2)28(23-7-4-3-5-8-23)13-11-25(12-14-28)21-30(24(32)31(25)22-27(34)9-6-10-27)18-15-26(33)16-19-37(35,36)20-17-26/h3-5,7-8,33-34H,6,9-22H2,1-2H3/t25-,28+
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125n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464637
PNG
(CIS-8-Dimethylamino-1,3-bis(2-methylsulfonyl-ethyl...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3CCN(CC3)c3cncnc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H42N6O/c1-33(2)30(26-6-4-3-5-7-26)14-12-29(13-15-30)22-35(28(37)36(29)21-24-8-9-24)20-25-10-16-34(17-11-25)27-18-31-23-32-19-27/h3-7,18-19,23-25H,8-17,20-22H2,1-2H3/t29-,30+
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140n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464637
PNG
(CIS-8-Dimethylamino-1,3-bis(2-methylsulfonyl-ethyl...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3CCN(CC3)c3cncnc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H42N6O/c1-33(2)30(26-6-4-3-5-7-26)14-12-29(13-15-30)22-35(28(37)36(29)21-24-8-9-24)20-25-10-16-34(17-11-25)27-18-31-23-32-19-27/h3-7,18-19,23-25H,8-17,20-22H2,1-2H3/t29-,30+
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140n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464598
PNG
(CIS-3-[1-[(1-Hydroxy-cyclobutyl)-methyl]-8-methyla...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCN3CCOCC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H42N4O3/c1-28(2)27(23-7-4-3-5-8-23)13-11-25(12-14-27)21-30(16-15-29-17-19-34-20-18-29)24(32)31(25)22-26(33)9-6-10-26/h3-5,7-8,33H,6,9-22H2,1-2H3/t25-,27+
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140n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464650
PNG
(CIS-8-Dimethylamino-3-(2-methylsulfonyl-ethyl)-1-(...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H43N3O5S/c1-29(2)28(23-7-4-3-5-8-23)13-11-25(12-14-28)21-30(24(32)31(25)22-27(34)9-6-10-27)18-15-26(33)16-19-37(35,36)20-17-26/h3-5,7-8,33-34H,6,9-22H2,1-2H3/t25-,28+
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145n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464598
PNG
(CIS-3-[1-[(1-Hydroxy-cyclobutyl)-methyl]-8-methyla...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCN3CCOCC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H42N4O3/c1-28(2)27(23-7-4-3-5-8-23)13-11-25(12-14-27)21-30(16-15-29-17-19-34-20-18-29)24(32)31(25)22-26(33)9-6-10-26/h3-5,7-8,33H,6,9-22H2,1-2H3/t25-,27+
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155n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464605
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-3-(2-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O4S/c1-28(2)27(23-7-4-3-5-8-23)15-13-25(14-16-27)20-29(19-22-9-17-35(33,34)18-10-22)24(31)30(25)21-26(32)11-6-12-26/h3-5,7-8,22,32H,6,9-21H2,1-2H3/t25-,27+
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165n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464620
PNG
(CIS-3-(1-Benzoyl-piperidin-4-yl)-1-(cyclopropyl-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(C3CCN(CC3)C(=O)c3ccncc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C31H41N5O2/c1-33(2)31(26-6-4-3-5-7-26)16-14-30(15-17-31)23-35(29(38)36(30)22-24-8-9-24)27-12-20-34(21-13-27)28(37)25-10-18-32-19-11-25/h3-7,10-11,18-19,24,27H,8-9,12-17,20-23H2,1-2H3/t30-,31+
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175n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464605
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-3-(2-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O4S/c1-28(2)27(23-7-4-3-5-8-23)15-13-25(14-16-27)20-29(19-22-9-17-35(33,34)18-10-22)24(31)30(25)21-26(32)11-6-12-26/h3-5,7-8,22,32H,6,9-21H2,1-2H3/t25-,27+
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185n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464598
PNG
(CIS-3-[1-[(1-Hydroxy-cyclobutyl)-methyl]-8-methyla...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCN3CCOCC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H42N4O3/c1-28(2)27(23-7-4-3-5-8-23)13-11-25(12-14-27)21-30(16-15-29-17-19-34-20-18-29)24(32)31(25)22-26(33)9-6-10-26/h3-5,7-8,33H,6,9-22H2,1-2H3/t25-,27+
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206n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464591
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCS(C)(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C24H37N3O4S/c1-25(2)24(20-8-5-4-6-9-20)14-12-22(13-15-24)18-26(16-17-32(3,30)31)21(28)27(22)19-23(29)10-7-11-23/h4-6,8-9,29H,7,10-19H2,1-3H3/t22-,24+
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210n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464605
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-3-(2-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O4S/c1-28(2)27(23-7-4-3-5-8-23)15-13-25(14-16-27)20-29(19-22-9-17-35(33,34)18-10-22)24(31)30(25)21-26(32)11-6-12-26/h3-5,7-8,22,32H,6,9-21H2,1-2H3/t25-,27+
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210n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464620
PNG
(CIS-3-(1-Benzoyl-piperidin-4-yl)-1-(cyclopropyl-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(C3CCN(CC3)C(=O)c3ccncc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C31H41N5O2/c1-33(2)31(26-6-4-3-5-7-26)16-14-30(15-17-31)23-35(29(38)36(30)22-24-8-9-24)27-12-20-34(21-13-27)28(37)25-10-18-32-19-11-25/h3-7,10-11,18-19,24,27H,8-9,12-17,20-23H2,1-2H3/t30-,31+
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220n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464675
PNG
(CIS-3-[1-(Cyclopropyl-methyl)-8-dimethylamino-2-ox...)
Show SMILES CN(C)[C@@]1(CC[C@]2(CN(CC(C)(C)C#N)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H36N4O/c1-23(2,17-26)18-28-19-24(29(22(28)30)16-20-10-11-20)12-14-25(15-13-24,27(3)4)21-8-6-5-7-9-21/h5-9,20H,10-16,18-19H2,1-4H3/t24-,25-
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230n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464656
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)NS(C)(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H42N4O4S/c1-23(2,27-35(5,33)34)18-29-19-24(30(22(29)31)20-25(32)12-9-13-25)14-16-26(17-15-24,28(3)4)21-10-7-6-8-11-21/h6-8,10-11,27,32H,9,12-20H2,1-5H3/t24-,26+
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235n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464643
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-3-[2-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H43N3O4S/c1-29(2)28(24-9-4-3-5-10-24)13-11-26(12-14-28)22-30(25(32)31(26)21-23-7-6-8-23)18-15-27(33)16-19-36(34,35)20-17-27/h3-5,9-10,23,33H,6-8,11-22H2,1-2H3/t26-,28+
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235n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464605
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-3-(2-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O4S/c1-28(2)27(23-7-4-3-5-8-23)15-13-25(14-16-27)20-29(19-22-9-17-35(33,34)18-10-22)24(31)30(25)21-26(32)11-6-12-26/h3-5,7-8,22,32H,6,9-21H2,1-2H3/t25-,27+
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245n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464643
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-3-[2-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H43N3O4S/c1-29(2)28(24-9-4-3-5-10-24)13-11-26(12-14-28)22-30(25(32)31(26)21-23-7-6-8-23)18-15-27(33)16-19-36(34,35)20-17-27/h3-5,9-10,23,33H,6-8,11-22H2,1-2H3/t26-,28+
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255n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464620
PNG
(CIS-3-(1-Benzoyl-piperidin-4-yl)-1-(cyclopropyl-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(C3CCN(CC3)C(=O)c3ccncc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C31H41N5O2/c1-33(2)31(26-6-4-3-5-7-26)16-14-30(15-17-31)23-35(29(38)36(30)22-24-8-9-24)27-12-20-34(21-13-27)28(37)25-10-18-32-19-11-25/h3-7,10-11,18-19,24,27H,8-9,12-17,20-23H2,1-2H3/t30-,31+
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255n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464615
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O5S/c1-28(2)27(22-7-4-3-5-8-22)13-11-24(12-14-27)19-29(20-26(33)15-17-36(34,35)18-16-26)23(31)30(24)21-25(32)9-6-10-25/h3-5,7-8,32-33H,6,9-21H2,1-2H3/t24-,27+
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265n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464611
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O4S/c1-28(2)27(23-9-4-3-5-10-23)13-11-25(12-14-27)20-29(24(31)30(25)19-22-7-6-8-22)21-26(32)15-17-35(33,34)18-16-26/h3-5,9-10,22,32H,6-8,11-21H2,1-2H3/t25-,27+
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270n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464650
PNG
(CIS-8-Dimethylamino-3-(2-methylsulfonyl-ethyl)-1-(...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H43N3O5S/c1-29(2)28(23-7-4-3-5-8-23)13-11-25(12-14-28)21-30(24(32)31(25)22-27(34)9-6-10-27)18-15-26(33)16-19-37(35,36)20-17-26/h3-5,7-8,33-34H,6,9-22H2,1-2H3/t25-,28+
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270n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464662
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)N3CCCS3(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H44N4O4S/c1-25(2,32-18-9-19-37(32,35)36)20-30-21-26(31(24(30)33)22-27(34)12-8-13-27)14-16-28(17-15-26,29(3)4)23-10-6-5-7-11-23/h5-7,10-11,34H,8-9,12-22H2,1-4H3/t26-,28+
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275n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464598
PNG
(CIS-3-[1-[(1-Hydroxy-cyclobutyl)-methyl]-8-methyla...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCN3CCOCC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H42N4O3/c1-28(2)27(23-7-4-3-5-8-23)13-11-25(12-14-27)21-30(16-15-29-17-19-34-20-18-29)24(32)31(25)22-26(33)9-6-10-26/h3-5,7-8,33H,6,9-22H2,1-2H3/t25-,27+
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285n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464611
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O4S/c1-28(2)27(23-9-4-3-5-10-23)13-11-25(12-14-27)20-29(24(31)30(25)19-22-7-6-8-22)21-26(32)15-17-35(33,34)18-16-26/h3-5,9-10,22,32H,6-8,11-21H2,1-2H3/t25-,27+
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290n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464643
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-3-[2-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H43N3O4S/c1-29(2)28(24-9-4-3-5-10-24)13-11-26(12-14-28)22-30(25(32)31(26)21-23-7-6-8-23)18-15-27(33)16-19-36(34,35)20-17-27/h3-5,9-10,23,33H,6-8,11-22H2,1-2H3/t26-,28+
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300n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464675
PNG
(CIS-3-[1-(Cyclopropyl-methyl)-8-dimethylamino-2-ox...)
Show SMILES CN(C)[C@@]1(CC[C@]2(CN(CC(C)(C)C#N)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H36N4O/c1-23(2,17-26)18-28-19-24(29(22(28)30)16-20-10-11-20)12-14-25(15-13-24,27(3)4)21-8-6-5-7-9-21/h5-9,20H,10-16,18-19H2,1-4H3/t24-,25-
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305n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464584
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[2-[2-...)
Show SMILES COCCOCCOCCOCCOCCOCCOCCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C36H61N3O8/c1-37(2)36(33-10-5-4-6-11-33)14-12-35(13-15-36)31-38(34(40)39(35)30-32-8-7-9-32)16-17-42-20-21-44-24-25-46-28-29-47-27-26-45-23-22-43-19-18-41-3/h4-6,10-11,32H,7-9,12-31H2,1-3H3/t35-,36+
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305n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464669
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1cccc(F)c1
Show InChI InChI=1S/C27H40FN3O5S/c1-29(2)27(21-5-3-6-22(28)17-21)11-9-24(10-12-27)18-30(19-26(34)13-15-37(35,36)16-14-26)23(32)31(24)20-25(33)7-4-8-25/h3,5-6,17,33-34H,4,7-16,18-20H2,1-2H3/t24-,27+
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330n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464602
PNG
(CIS-3-Acetyl-8-dimethylamino-8-phenyl-1,3-diazaspi...)
Show SMILES COC(=O)CCCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C26H39N3O3/c1-27(2)26(22-11-5-4-6-12-22)16-14-25(15-17-26)20-28(18-8-13-23(30)32-3)24(31)29(25)19-21-9-7-10-21/h4-6,11-12,21H,7-10,13-20H2,1-3H3/t25-,26+
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345n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464595
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[2-[2-...)
Show SMILES COCCOCCOCCOCCOCCOCCOCCOCCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C38H65N3O9/c1-39(2)38(35-10-5-4-6-11-35)14-12-37(13-15-38)33-40(36(42)41(37)32-34-8-7-9-34)16-17-44-20-21-46-24-25-48-28-29-50-31-30-49-27-26-47-23-22-45-19-18-43-3/h4-6,10-11,34H,7-9,12-33H2,1-3H3/t37-,38+
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375n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464669
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1cccc(F)c1
Show InChI InChI=1S/C27H40FN3O5S/c1-29(2)27(21-5-3-6-22(28)17-21)11-9-24(10-12-27)18-30(19-26(34)13-15-37(35,36)16-14-26)23(32)31(24)20-25(33)7-4-8-25/h3,5-6,17,33-34H,4,7-16,18-20H2,1-2H3/t24-,27+
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395n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464615
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O5S/c1-28(2)27(22-7-4-3-5-8-22)13-11-24(12-14-27)19-29(20-26(33)15-17-36(34,35)18-16-26)23(31)30(24)21-25(32)9-6-10-25/h3-5,7-8,32-33H,6,9-21H2,1-2H3/t24-,27+
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415n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464650
PNG
(CIS-8-Dimethylamino-3-(2-methylsulfonyl-ethyl)-1-(...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H43N3O5S/c1-29(2)28(23-7-4-3-5-8-23)13-11-25(12-14-28)21-30(24(32)31(25)22-27(34)9-6-10-27)18-15-26(33)16-19-37(35,36)20-17-26/h3-5,7-8,33-34H,6,9-22H2,1-2H3/t25-,28+
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415n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464643
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-3-[2-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H43N3O4S/c1-29(2)28(24-9-4-3-5-10-24)13-11-26(12-14-28)22-30(25(32)31(26)21-23-7-6-8-23)18-15-27(33)16-19-36(34,35)20-17-27/h3-5,9-10,23,33H,6-8,11-22H2,1-2H3/t26-,28+
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460n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464656
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)NS(C)(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H42N4O4S/c1-23(2,27-35(5,33)34)18-29-19-24(30(22(29)31)20-25(32)12-9-13-25)14-16-26(17-15-24,28(3)4)21-10-7-6-8-11-21/h6-8,10-11,27,32H,9,12-20H2,1-5H3/t24-,26+
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495n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464631
PNG
(CIS-3-(1-Benzoyl-piperidin-4-yl)-8-dimethylamino-8...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H39N3O4S/c1-27(2)26(22-6-4-3-5-7-22)12-10-24(11-13-26)19-28(23(30)29(24)18-21-8-9-21)20-25(31)14-16-34(32,33)17-15-25/h3-7,21,31H,8-20H2,1-2H3/t24-,26+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464662
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)N3CCCS3(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H44N4O4S/c1-25(2,32-18-9-19-37(32,35)36)20-30-21-26(31(24(30)33)22-27(34)12-8-13-27)14-16-28(17-15-26,29(3)4)23-10-6-5-7-11-23/h5-7,10-11,34H,8-9,12-22H2,1-4H3/t26-,28+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464656
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)NS(C)(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H42N4O4S/c1-23(2,27-35(5,33)34)18-29-19-24(30(22(29)31)20-25(32)12-9-13-25)14-16-26(17-15-24,28(3)4)21-10-7-6-8-11-21/h6-8,10-11,27,32H,9,12-20H2,1-5H3/t24-,26+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464626
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(C3CCN(CC3)c3cncnc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H40N6O/c1-32(2)29(24-6-4-3-5-7-24)14-12-28(13-15-29)21-34(27(36)35(28)20-23-8-9-23)25-10-16-33(17-11-25)26-18-30-22-31-19-26/h3-7,18-19,22-23,25H,8-17,20-21H2,1-2H3/t28-,29+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464598
PNG
(CIS-3-[1-[(1-Hydroxy-cyclobutyl)-methyl]-8-methyla...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCN3CCOCC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H42N4O3/c1-28(2)27(23-7-4-3-5-8-23)13-11-25(12-14-27)21-30(16-15-29-17-19-34-20-18-29)24(32)31(25)22-26(33)9-6-10-26/h3-5,7-8,33H,6,9-22H2,1-2H3/t25-,27+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464656
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)NS(C)(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H42N4O4S/c1-23(2,27-35(5,33)34)18-29-19-24(30(22(29)31)20-25(32)12-9-13-25)14-16-26(17-15-24,28(3)4)21-10-7-6-8-11-21/h6-8,10-11,27,32H,9,12-20H2,1-5H3/t24-,26+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464637
PNG
(CIS-8-Dimethylamino-1,3-bis(2-methylsulfonyl-ethyl...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3CCN(CC3)c3cncnc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H42N6O/c1-33(2)30(26-6-4-3-5-7-26)14-12-29(13-15-30)22-35(28(37)36(29)21-24-8-9-24)20-25-10-16-34(17-11-25)27-18-31-23-32-19-27/h3-7,18-19,23-25H,8-17,20-22H2,1-2H3/t29-,30+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464667
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-(3-fl...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(C3CCN(CC3)c3cncnc3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H42N6O2/c1-33(2)30(24-7-4-3-5-8-24)15-13-28(14-16-30)21-35(27(37)36(28)22-29(38)11-6-12-29)25-9-17-34(18-10-25)26-19-31-23-32-20-26/h3-5,7-8,19-20,23,25,38H,6,9-18,21-22H2,1-2H3/t28-,30+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464597
PNG
(CIS-1-[(1-Hydroxy-cyclobutyl)-methyl]-8-methylamin...)
Show SMILES CN[C@]1(CC[C@]2(CN(CCS(C)(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C23H35N3O4S/c1-24-23(19-7-4-3-5-8-19)13-11-21(12-14-23)17-25(15-16-31(2,29)30)20(27)26(21)18-22(28)9-6-10-22/h3-5,7-8,24,28H,6,9-18H2,1-2H3/t21-,23+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464598
PNG
(CIS-3-[1-[(1-Hydroxy-cyclobutyl)-methyl]-8-methyla...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCN3CCOCC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H42N4O3/c1-28(2)27(23-7-4-3-5-8-23)13-11-25(12-14-27)21-30(16-15-29-17-19-34-20-18-29)24(32)31(25)22-26(33)9-6-10-26/h3-5,7-8,33H,6,9-22H2,1-2H3/t25-,27+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464615
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O5S/c1-28(2)27(22-7-4-3-5-8-22)13-11-24(12-14-27)19-29(20-26(33)15-17-36(34,35)18-16-26)23(31)30(24)21-25(32)9-6-10-25/h3-5,7-8,32-33H,6,9-21H2,1-2H3/t24-,27+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464672
PNG
(CIS-3-[8-(Ethyl-methyl-amino)-2-oxo-8-phenyl-1,3-d...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C#N)C(=O)N2CC2(F)CC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H35FN4O/c1-22(2,16-27)17-29-19-24(30(21(29)31)18-23(26)10-11-23)12-14-25(15-13-24,28(3)4)20-8-6-5-7-9-20/h5-9H,10-15,17-19H2,1-4H3/t24-,25+
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GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464672
PNG
(CIS-3-[8-(Ethyl-methyl-amino)-2-oxo-8-phenyl-1,3-d...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C#N)C(=O)N2CC2(F)CC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H35FN4O/c1-22(2,16-27)17-29-19-24(30(21(29)31)18-23(26)10-11-23)12-14-25(15-13-24,28(3)4)20-8-6-5-7-9-20/h5-9H,10-15,17-19H2,1-4H3/t24-,25+
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GRUENENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464631
PNG
(CIS-3-(1-Benzoyl-piperidin-4-yl)-8-dimethylamino-8...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H39N3O4S/c1-27(2)26(22-6-4-3-5-7-22)12-10-24(11-13-26)19-28(23(30)29(24)18-21-8-9-21)20-25(31)14-16-34(32,33)17-15-25/h3-7,21,31H,8-20H2,1-2H3/t24-,26+
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710n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464631
PNG
(CIS-3-(1-Benzoyl-piperidin-4-yl)-8-dimethylamino-8...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H39N3O4S/c1-27(2)26(22-6-4-3-5-7-22)12-10-24(11-13-26)19-28(23(30)29(24)18-21-8-9-21)20-25(31)14-16-34(32,33)17-15-25/h3-7,21,31H,8-20H2,1-2H3/t24-,26+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464582
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[2-[2-...)
Show SMILES COCCOCCOCCOCCOCCOCCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C34H57N3O7/c1-35(2)34(31-10-5-4-6-11-31)14-12-33(13-15-34)29-36(32(38)37(33)28-30-8-7-9-30)16-17-40-20-21-42-24-25-44-27-26-43-23-22-41-19-18-39-3/h4-6,10-11,30H,7-9,12-29H2,1-3H3/t33-,34+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464650
PNG
(CIS-8-Dimethylamino-3-(2-methylsulfonyl-ethyl)-1-(...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H43N3O5S/c1-29(2)28(23-7-4-3-5-8-23)13-11-25(12-14-28)21-30(24(32)31(25)22-27(34)9-6-10-27)18-15-26(33)16-19-37(35,36)20-17-26/h3-5,7-8,33-34H,6,9-22H2,1-2H3/t25-,28+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464620
PNG
(CIS-3-(1-Benzoyl-piperidin-4-yl)-1-(cyclopropyl-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(C3CCN(CC3)C(=O)c3ccncc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C31H41N5O2/c1-33(2)31(26-6-4-3-5-7-26)16-14-30(15-17-31)23-35(29(38)36(30)22-24-8-9-24)27-12-20-34(21-13-27)28(37)25-10-18-32-19-11-25/h3-7,10-11,18-19,24,27H,8-9,12-17,20-23H2,1-2H3/t30-,31+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464615
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O5S/c1-28(2)27(22-7-4-3-5-8-22)13-11-24(12-14-27)19-29(20-26(33)15-17-36(34,35)18-16-26)23(31)30(24)21-25(32)9-6-10-25/h3-5,7-8,32-33H,6,9-21H2,1-2H3/t24-,27+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464605
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-3-(2-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O4S/c1-28(2)27(23-7-4-3-5-8-23)15-13-25(14-16-27)20-29(19-22-9-17-35(33,34)18-10-22)24(31)30(25)21-26(32)11-6-12-26/h3-5,7-8,22,32H,6,9-21H2,1-2H3/t25-,27+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464656
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)NS(C)(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H42N4O4S/c1-23(2,27-35(5,33)34)18-29-19-24(30(22(29)31)20-25(32)12-9-13-25)14-16-26(17-15-24,28(3)4)21-10-7-6-8-11-21/h6-8,10-11,27,32H,9,12-20H2,1-5H3/t24-,26+
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Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464637
PNG
(CIS-8-Dimethylamino-1,3-bis(2-methylsulfonyl-ethyl...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3CCN(CC3)c3cncnc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H42N6O/c1-33(2)30(26-6-4-3-5-7-26)14-12-29(13-15-30)22-35(28(37)36(29)21-24-8-9-24)20-25-10-16-34(17-11-25)27-18-31-23-32-19-27/h3-7,18-19,23-25H,8-17,20-22H2,1-2H3/t29-,30+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464662
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)N3CCCS3(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H44N4O4S/c1-25(2,32-18-9-19-37(32,35)36)20-30-21-26(31(24(30)33)22-27(34)12-8-13-27)14-16-28(17-15-26,29(3)4)23-10-6-5-7-11-23/h5-7,10-11,34H,8-9,12-22H2,1-4H3/t26-,28+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464626
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(C3CCN(CC3)c3cncnc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H40N6O/c1-32(2)29(24-6-4-3-5-7-24)14-12-28(13-15-29)21-34(27(36)35(28)20-23-8-9-23)25-10-16-33(17-11-25)26-18-30-22-31-19-26/h3-7,18-19,22-23,25H,8-17,20-21H2,1-2H3/t28-,29+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464615
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O5S/c1-28(2)27(22-7-4-3-5-8-22)13-11-24(12-14-27)19-29(20-26(33)15-17-36(34,35)18-16-26)23(31)30(24)21-25(32)9-6-10-25/h3-5,7-8,32-33H,6,9-21H2,1-2H3/t24-,27+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM464631
PNG
(CIS-3-(1-Benzoyl-piperidin-4-yl)-8-dimethylamino-8...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H39N3O4S/c1-27(2)26(22-6-4-3-5-7-22)12-10-24(11-13-26)19-28(23(30)29(24)18-21-8-9-21)20-25(31)14-16-34(32,33)17-15-25/h3-7,21,31H,8-20H2,1-2H3/t24-,26+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464605
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-3-(2-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O4S/c1-28(2)27(23-7-4-3-5-8-23)15-13-25(14-16-27)20-29(19-22-9-17-35(33,34)18-10-22)24(31)30(25)21-26(32)11-6-12-26/h3-5,7-8,22,32H,6,9-21H2,1-2H3/t25-,27+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464626
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(C3CCN(CC3)c3cncnc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H40N6O/c1-32(2)29(24-6-4-3-5-7-24)14-12-28(13-15-29)21-34(27(36)35(28)20-23-8-9-23)25-10-16-33(17-11-25)26-18-30-22-31-19-26/h3-7,18-19,22-23,25H,8-17,20-21H2,1-2H3/t28-,29+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464620
PNG
(CIS-3-(1-Benzoyl-piperidin-4-yl)-1-(cyclopropyl-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(C3CCN(CC3)C(=O)c3ccncc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C31H41N5O2/c1-33(2)31(26-6-4-3-5-7-26)16-14-30(15-17-31)23-35(29(38)36(30)22-24-8-9-24)27-12-20-34(21-13-27)28(37)25-10-18-32-19-11-25/h3-7,10-11,18-19,24,27H,8-9,12-17,20-23H2,1-2H3/t30-,31+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464602
PNG
(CIS-3-Acetyl-8-dimethylamino-8-phenyl-1,3-diazaspi...)
Show SMILES COC(=O)CCCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C26H39N3O3/c1-27(2)26(22-11-5-4-6-12-22)16-14-25(15-17-26)20-28(18-8-13-23(30)32-3)24(31)29(25)19-21-9-7-10-21/h4-6,11-12,21H,7-10,13-20H2,1-3H3/t25-,26+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464605
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-3-(2-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H41N3O4S/c1-28(2)27(23-7-4-3-5-8-23)15-13-25(14-16-27)20-29(19-22-9-17-35(33,34)18-10-22)24(31)30(25)21-26(32)11-6-12-26/h3-5,7-8,22,32H,6,9-21H2,1-2H3/t25-,27+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464626
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(C3CCN(CC3)c3cncnc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H40N6O/c1-32(2)29(24-6-4-3-5-7-24)14-12-28(13-15-29)21-34(27(36)35(28)20-23-8-9-23)25-10-16-33(17-11-25)26-18-30-22-31-19-26/h3-7,18-19,22-23,25H,8-17,20-21H2,1-2H3/t28-,29+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464631
PNG
(CIS-3-(1-Benzoyl-piperidin-4-yl)-8-dimethylamino-8...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H39N3O4S/c1-27(2)26(22-6-4-3-5-7-22)12-10-24(11-13-26)19-28(23(30)29(24)18-21-8-9-21)20-25(31)14-16-34(32,33)17-15-25/h3-7,21,31H,8-20H2,1-2H3/t24-,26+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464626
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(C3CCN(CC3)c3cncnc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H40N6O/c1-32(2)29(24-6-4-3-5-7-24)14-12-28(13-15-29)21-34(27(36)35(28)20-23-8-9-23)25-10-16-33(17-11-25)26-18-30-22-31-19-26/h3-7,18-19,22-23,25H,8-17,20-21H2,1-2H3/t28-,29+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464667
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-(3-fl...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(C3CCN(CC3)c3cncnc3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H42N6O2/c1-33(2)30(24-7-4-3-5-8-24)15-13-28(14-16-30)21-35(27(37)36(28)22-29(38)11-6-12-29)25-9-17-34(18-10-25)26-19-31-23-32-20-26/h3-5,7-8,19-20,23,25,38H,6,9-18,21-22H2,1-2H3/t28-,30+
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1.98E+3n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464656
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)NS(C)(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H42N4O4S/c1-23(2,27-35(5,33)34)18-29-19-24(30(22(29)31)20-25(32)12-9-13-25)14-16-26(17-15-24,28(3)4)21-10-7-6-8-11-21/h6-8,10-11,27,32H,9,12-20H2,1-5H3/t24-,26+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464631
PNG
(CIS-3-(1-Benzoyl-piperidin-4-yl)-8-dimethylamino-8...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H39N3O4S/c1-27(2)26(22-6-4-3-5-7-22)12-10-24(11-13-26)19-28(23(30)29(24)18-21-8-9-21)20-25(31)14-16-34(32,33)17-15-25/h3-7,21,31H,8-20H2,1-2H3/t24-,26+
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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464672
PNG
(CIS-3-[8-(Ethyl-methyl-amino)-2-oxo-8-phenyl-1,3-d...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C#N)C(=O)N2CC2(F)CC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H35FN4O/c1-22(2,16-27)17-29-19-24(30(21(29)31)18-23(26)10-11-23)12-14-25(15-13-24,28(3)4)20-8-6-5-7-9-20/h5-9H,10-15,17-19H2,1-4H3/t24-,25+
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2.93E+3n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464637
PNG
(CIS-8-Dimethylamino-1,3-bis(2-methylsulfonyl-ethyl...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3CCN(CC3)c3cncnc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H42N6O/c1-33(2)30(26-6-4-3-5-7-26)14-12-29(13-15-30)22-35(28(37)36(29)21-24-8-9-24)20-25-10-16-34(17-11-25)27-18-31-23-32-19-27/h3-7,18-19,23-25H,8-17,20-22H2,1-2H3/t29-,30+
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3.05E+3n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464650
PNG
(CIS-8-Dimethylamino-3-(2-methylsulfonyl-ethyl)-1-(...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H43N3O5S/c1-29(2)28(23-7-4-3-5-8-23)13-11-25(12-14-28)21-30(24(32)31(25)22-27(34)9-6-10-27)18-15-26(33)16-19-37(35,36)20-17-26/h3-5,7-8,33-34H,6,9-22H2,1-2H3/t25-,28+
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3.23E+3n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464650
PNG
(CIS-8-Dimethylamino-3-(2-methylsulfonyl-ethyl)-1-(...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H43N3O5S/c1-29(2)28(23-7-4-3-5-8-23)13-11-25(12-14-28)21-30(24(32)31(25)22-27(34)9-6-10-27)18-15-26(33)16-19-37(35,36)20-17-26/h3-5,7-8,33-34H,6,9-22H2,1-2H3/t25-,28+
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4.15E+3n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464669
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1cccc(F)c1
Show InChI InChI=1S/C27H40FN3O5S/c1-29(2)27(21-5-3-6-22(28)17-21)11-9-24(10-12-27)18-30(19-26(34)13-15-37(35,36)16-14-26)23(32)31(24)20-25(33)7-4-8-25/h3,5-6,17,33-34H,4,7-16,18-20H2,1-2H3/t24-,27+
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4.36E+3n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464637
PNG
(CIS-8-Dimethylamino-1,3-bis(2-methylsulfonyl-ethyl...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC3CCN(CC3)c3cncnc3)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H42N6O/c1-33(2)30(26-6-4-3-5-7-26)14-12-29(13-15-30)22-35(28(37)36(29)21-24-8-9-24)20-25-10-16-34(17-11-25)27-18-31-23-32-19-27/h3-7,18-19,23-25H,8-17,20-22H2,1-2H3/t29-,30+
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6.90E+3n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM464602
PNG
(CIS-3-Acetyl-8-dimethylamino-8-phenyl-1,3-diazaspi...)
Show SMILES COC(=O)CCCN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C26H39N3O3/c1-27(2)26(22-11-5-4-6-12-22)16-14-25(15-17-26)20-28(18-8-13-23(30)32-3)24(31)29(25)19-21-9-7-10-21/h4-6,11-12,21H,7-10,13-20H2,1-3H3/t25-,26+
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8.53E+3n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...


US Patent US10793556 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%