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Patent code US10793565

Compile Data Set for Download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PD-1/PD-L1


(Homo sapiens (Human))
BDBM465361
PNG
(2-((8-chloro-2-(2,2′-dimethyl-3′-(4,5,...)
Show SMILES Cc1c(cccc1-c1cccc(-c2nc3CCNCc3s2)c1C)-c1nc2c(Cl)cc(CNCCO)cn2n1
Show InChI InChI=1S/C29H29ClN6OS/c1-17-20(21-6-4-8-23(18(21)2)29-33-25-9-10-31-15-26(25)38-29)5-3-7-22(17)27-34-28-24(30)13-19(14-32-11-12-37)16-36(28)35-27/h3-8,13,16,31-32,37H,9-12,14-15H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The assays were conducted in a standard black 384-well polystyrene plate with a final volume of 20 μL. Inhibitors were first serially diluted in...


US Patent US10793565 (2020)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens (Human))
BDBM465358
PNG
(N-(3′-(8-chloro-6-((2-hydroxyethylamino)meth...)
Show SMILES Cc1c(NC(=O)c2ccc(CNCCO)cn2)cccc1-c1cccc(-c2nc3c(Cl)cc(CNCCO)cn3n2)c1C
Show InChI InChI=1S/C32H34ClN7O3/c1-20-24(5-3-7-26(20)30-38-31-27(33)15-23(17-35-12-14-42)19-40(31)39-30)25-6-4-8-28(21(25)2)37-32(43)29-10-9-22(18-36-29)16-34-11-13-41/h3-10,15,18-19,34-35,41-42H,11-14,16-17H2,1-2H3,(H,37,43)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The assays were conducted in a standard black 384-well polystyrene plate with a final volume of 20 μL. Inhibitors were first serially diluted in...


US Patent US10793565 (2020)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens (Human))
BDBM465359
PNG
(N-(2-chloro-3′-(8-chloro-6-((2-hydroxyethyla...)
Show SMILES Cc1c(cccc1-c1cccc(NC(=O)c2ccc(CNCCO)cn2)c1Cl)-c1nc2c(Cl)cc(CNCCO)cn2n1
Show InChI InChI=1S/C31H31Cl2N7O3/c1-19-22(4-2-5-23(19)29-38-30-25(32)14-21(16-35-11-13-42)18-40(30)39-29)24-6-3-7-26(28(24)33)37-31(43)27-9-8-20(17-36-27)15-34-10-12-41/h2-9,14,17-18,34-35,41-42H,10-13,15-16H2,1H3,(H,37,43)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The assays were conducted in a standard black 384-well polystyrene plate with a final volume of 20 μL. Inhibitors were first serially diluted in...


US Patent US10793565 (2020)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens (Human))
BDBM465360
PNG
(N-(2-chloro-3′-(8-cyano-6-((2-hydroxyethylam...)
Show SMILES Cc1c(cccc1-c1cccc(NC(=O)c2ccc(CNCCO)cn2)c1Cl)-c1nc2c(cc(CNCCO)cn2n1)C#N
Show InChI InChI=1S/C32H31ClN8O3/c1-20-24(4-2-5-25(20)30-39-31-23(15-34)14-22(17-36-11-13-43)19-41(31)40-30)26-6-3-7-27(29(26)33)38-32(44)28-9-8-21(18-37-28)16-35-10-12-42/h2-9,14,18-19,35-36,42-43H,10-13,16-17H2,1H3,(H,38,44)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The assays were conducted in a standard black 384-well polystyrene plate with a final volume of 20 μL. Inhibitors were first serially diluted in...


US Patent US10793565 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%