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Patent code US10793566

Compile Data Set for Download or QSAR
Found 134 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465365
PNG
(US10793566, Compound 4)
Show SMILES Fc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ccncc23)c1Cl
Show InChI InChI=1S/C25H20ClFN4O2/c1-2-23(32)30-13-11-17(15-30)31-21-10-12-28-14-19(21)25(29-31)16-6-8-18(9-7-16)33-22-5-3-4-20(27)24(22)26/h2-10,12,14,17H,1,11,13,15H2/t17-/m1/s1
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n/an/a<10n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444723
PNG
((R)-1-(3-(7-(2-(dimethylamino)ethoxy)-3-(4- (2-flu...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3c(OCCN(C)C)cncc23)c1F
Show InChI InChI=1S/C31H34FN5O4/c1-5-28(38)36-15-7-8-22(20-36)37-31-24(18-33-19-27(31)40-17-16-35(2)3)30(34-37)21-11-13-23(14-12-21)41-26-10-6-9-25(39-4)29(26)32/h5-6,9-14,18-19,22H,1,7-8,15-17,20H2,2-4H3/t22-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444658
PNG
((R)-1-(1-acryloylpyrrolidin-3-yl)-3-(4-(2- fluoro-...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCN(C3)C(=O)C=C)c3c(cncc23)C#N)c1F
Show InChI InChI=1S/C27H22FN5O3/c1-3-24(34)32-12-11-19(16-32)33-27-18(13-29)14-30-15-21(27)26(31-33)17-7-9-20(10-8-17)36-23-6-4-5-22(35-2)25(23)28/h3-10,14-15,19H,1,11-12,16H2,2H3/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444688
PNG
((R)-1-(3-(3-(4-((3- fluorophenyl)thio)phenyl)-1H- ...)
Show SMILES Fc1cccc(Sc2ccc(cc2)-c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ccncc23)c1
Show InChI InChI=1S/C25H21FN4OS/c1-2-24(31)29-13-11-19(16-29)30-23-10-12-27-15-22(23)25(28-30)17-6-8-20(9-7-17)32-21-5-3-4-18(26)14-21/h2-10,12,14-15,19H,1,11,13,16H2/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444697
PNG
((R)-1-(3-(7-(difluoromethyl)-3-(4-(2-fluoro-3- mel...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCN(C3)C(=O)C=C)c3c(cncc23)C(F)F)c1F
Show InChI InChI=1S/C27H23F3N4O3/c1-3-23(35)33-12-11-17(15-33)34-26-19(13-31-14-20(26)27(29)30)25(32-34)16-7-9-18(10-8-16)37-22-6-4-5-21(36-2)24(22)28/h3-10,13-14,17,27H,1,11-12,15H2,2H3/t17-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444708
PNG
((R)-1-(3-(3-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ccnc(C)c23)c1F
Show InChI InChI=1S/C28H27FN4O3/c1-4-25(34)32-16-6-7-20(17-32)33-22-14-15-30-18(2)26(22)28(31-33)19-10-12-21(13-11-19)36-24-9-5-8-23(35-3)27(24)29/h4-5,8-15,20H,1,6-7,16-17H2,2-3H3/t20-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444709
PNG
((R)-1-(3-(3-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCN(C3)C(=O)C=C)c3c(OC)cncc23)c1F
Show InChI InChI=1S/C27H25FN4O4/c1-4-24(33)31-13-12-18(16-31)32-27-20(14-29-15-23(27)35-3)26(30-32)17-8-10-19(11-9-17)36-22-7-5-6-21(34-2)25(22)28/h4-11,14-15,18H,1,12-13,16H2,2-3H3/t18-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444727
PNG
((R)-1-(3-(3-(4-(2-chloro-3- methoxyphenoxy)phenyl)...)
Show SMILES CCOc1cncc2c(nn([C@@H]3CCN(C3)C(=O)C=C)c12)-c1ccc(Oc2cccc(OC)c2Cl)cc1
Show InChI InChI=1S/C28H27ClN4O4/c1-4-25(34)32-14-13-19(17-32)33-28-21(15-30-16-24(28)36-5-2)27(31-33)18-9-11-20(12-10-18)37-23-8-6-7-22(35-3)26(23)29/h4,6-12,15-16,19H,1,5,13-14,17H2,2-3H3/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444752
PNG
(4-(3-(4-(2-fluoro-3- methoxyphenoxy)phenyl)-7- met...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn(C3CCC(CC3)C(O)=O)c3c(OC)cncc23)c1F
Show InChI InChI=1S/C27H26FN3O5/c1-34-21-4-3-5-22(24(21)28)36-19-12-8-16(9-13-19)25-20-14-29-15-23(35-2)26(20)31(30-25)18-10-6-17(7-11-18)27(32)33/h3-5,8-9,12-15,17-18H,6-7,10-11H2,1-2H3,(H,32,33)
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444700
PNG
((R)-1-(3-(7-fluoro-3-(4-(2-fluoro-3- methoxyphenox...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3c(F)cncc23)c1F
Show InChI InChI=1S/C27H24F2N4O3/c1-3-24(34)32-13-5-6-18(16-32)33-27-20(14-30-15-21(27)28)26(31-33)17-9-11-19(12-10-17)36-23-8-4-7-22(35-2)25(23)29/h3-4,7-12,14-15,18H,1,5-6,13,16H2,2H3/t18-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465364
PNG
(US10793566, Compound 3)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ccncc23)c1F
Show InChI InChI=1S/C26H23FN4O3/c1-3-24(32)30-14-12-18(16-30)31-21-11-13-28-15-20(21)26(29-31)17-7-9-19(10-8-17)34-23-6-4-5-22(33-2)25(23)27/h3-11,13,15,18H,1,12,14,16H2,2H3/t18-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444648
PNG
((R)-1-(3-(3-(4-(2,3- difluorophenoxy)phenyl)-1H- p...)
Show SMILES Fc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ccncc23)c1F
Show InChI InChI=1S/C25H20F2N4O2/c1-2-23(32)30-13-11-17(15-30)31-21-10-12-28-14-19(21)25(29-31)16-6-8-18(9-7-16)33-22-5-3-4-20(26)24(22)27/h2-10,12,14,17H,1,11,13,15H2/t17-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444650
PNG
((R)-1-(3-(3-(4-(3-chloro-2- fluorophenoxy)phenyl)-...)
Show SMILES Fc1c(Cl)cccc1Oc1ccc(cc1)-c1nn([C@@H]2CCCN(C2)C(=O)C=C)c2ccncc12
Show InChI InChI=1S/C26H22ClFN4O2/c1-2-24(33)31-14-4-5-18(16-31)32-22-12-13-29-15-20(22)26(30-32)17-8-10-19(11-9-17)34-23-7-3-6-21(27)25(23)28/h2-3,6-13,15,18H,1,4-5,14,16H2/t18-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444673
PNG
((R)-1-(3-(3-(4-(2,3- dichlorophenoxy)phenyl)-2H- p...)
Show SMILES Clc1cccc(Oc2ccc(cc2)-c2n(nc3ccncc23)C2CCCN(C2)C(=O)C=C)c1Cl
Show InChI InChI=1S/C26H22Cl2N4O2/c1-2-24(33)31-14-4-5-18(16-31)32-26(20-15-29-13-12-22(20)30-32)17-8-10-19(11-9-17)34-23-7-3-6-21(27)25(23)28/h2-3,6-13,15,18H,1,4-5,14,16H2
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444674
PNG
((S)-1-(3-(3-(4-(2,3- dichlorophenoxy)phenyl)-1H- p...)
Show SMILES Clc1cccc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C(=O)C=C)c3ccncc23)c1Cl
Show InChI InChI=1S/C26H22Cl2N4O2/c1-2-24(33)31-14-4-5-18(16-31)32-22-12-13-29-15-20(22)26(30-32)17-8-10-19(11-9-17)34-23-7-3-6-21(27)25(23)28/h2-3,6-13,15,18H,1,4-5,14,16H2
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444707
PNG
((R)-1-(3-(3-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES CCCOc1cncc2c(nn([C@@H]3CCCN(C3)C(=O)C=C)c12)-c1ccc(Oc2cccc(OC)c2F)cc1
Show InChI InChI=1S/C30H31FN4O4/c1-4-16-38-26-18-32-17-23-29(33-35(30(23)26)21-8-7-15-34(19-21)27(36)5-2)20-11-13-22(14-12-20)39-25-10-6-9-24(37-3)28(25)31/h5-6,9-14,17-18,21H,2,4,7-8,15-16,19H2,1,3H3/t21-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444714
PNG
((R)-1-(3-(7-butoxy-3-(4-(2-chloro-3- methoxyphenox...)
Show SMILES CCCCOc1cncc2c(nn([C@@H]3CCCN(C3)C(=O)C=C)c12)-c1ccc(Oc2cccc(OC)c2Cl)cc1
Show InChI InChI=1S/C31H33ClN4O4/c1-4-6-17-39-27-19-33-18-24-30(34-36(31(24)27)22-9-8-16-35(20-22)28(37)5-2)21-12-14-23(15-13-21)40-26-11-7-10-25(38-3)29(26)32/h5,7,10-15,18-19,22H,2,4,6,8-9,16-17,20H2,1,3H3/t22-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444716
PNG
(1-((3R)-3-(3-(4-(2-chloro-3- methoxyphenoxy)phenyl...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3c(OC4CCOC4)cncc23)c1Cl
Show InChI InChI=1S/C31H31ClN4O5/c1-3-28(37)35-14-5-6-21(18-35)36-31-24(16-33-17-27(31)41-23-13-15-39-19-23)30(34-36)20-9-11-22(12-10-20)40-26-8-4-7-25(38-2)29(26)32/h3-4,7-12,16-17,21,23H,1,5-6,13-15,18-19H2,2H3/t21-,23?/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444728
PNG
((R)-1-(3-(3-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3c(OCCO)cncc23)c1F
Show InChI InChI=1S/C29H29FN4O5/c1-3-26(36)33-13-5-6-20(18-33)34-29-22(16-31-17-25(29)38-15-14-35)28(32-34)19-9-11-21(12-10-19)39-24-8-4-7-23(37-2)27(24)30/h3-4,7-12,16-17,20,35H,1,5-6,13-15,18H2,2H3/t20-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444671
PNG
((R)-1-(3-(3-(4-(2,3- dichlorophenoxy)phenyl)-2H- p...)
Show SMILES Clc1cccc(Oc2ccc(cc2)-c2n(nc3ccncc23)C2CCN(C2)C(=O)C=C)c1Cl
Show InChI InChI=1S/C25H20Cl2N4O2/c1-2-23(32)30-13-11-17(15-30)31-25(19-14-28-12-10-21(19)29-31)16-6-8-18(9-7-16)33-22-5-3-4-20(26)24(22)27/h2-10,12,14,17H,1,11,13,15H2
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444677
PNG
((R)-1-(3-(3-(4-(2-fluoro-3- methylphenoxy)phenyl)-...)
Show SMILES Cc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ccncc23)c1F
Show InChI InChI=1S/C26H23FN4O2/c1-3-24(32)30-14-12-19(16-30)31-22-11-13-28-15-21(22)26(29-31)18-7-9-20(10-8-18)33-23-6-4-5-17(2)25(23)27/h3-11,13,15,19H,1,12,14,16H2,2H3/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444699
PNG
((R)-1-(3-(3-(4-(2-chloro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCN(C3)C(=O)C=C)c3c(OC)cncc23)c1Cl
Show InChI InChI=1S/C27H25ClN4O4/c1-4-24(33)31-13-12-18(16-31)32-27-20(14-29-15-23(27)35-3)26(30-32)17-8-10-19(11-9-17)36-22-7-5-6-21(34-2)25(22)28/h4-11,14-15,18H,1,12-13,16H2,2-3H3/t18-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444705
PNG
((R)-1-(3-(3-(4-(2-chloro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3c(OC)cncc23)c1Cl
Show InChI InChI=1S/C28H27ClN4O4/c1-4-25(34)32-14-6-7-19(17-32)33-28-21(15-30-16-24(28)36-3)27(31-33)18-10-12-20(13-11-18)37-23-9-5-8-22(35-2)26(23)29/h4-5,8-13,15-16,19H,1,6-7,14,17H2,2-3H3/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444710
PNG
((R)-1-(3-(7-cthoxy-3-(4-(2-fluoro-3- methoxyphenox...)
Show SMILES CCOc1cncc2c(nn([C@@H]3CCN(C3)C(=O)C=C)c12)-c1ccc(Oc2cccc(OC)c2F)cc1
Show InChI InChI=1S/C28H27FN4O4/c1-4-25(34)32-14-13-19(17-32)33-28-21(15-30-16-24(28)36-5-2)27(31-33)18-9-11-20(12-10-18)37-23-8-6-7-22(35-3)26(23)29/h4,6-12,15-16,19H,1,5,13-14,17H2,2-3H3/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444715
PNG
((R)-1-(3-(3-(4-(2-chloro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3c(OC(C)C)cncc23)c1Cl
Show InChI InChI=1S/C30H31ClN4O4/c1-5-27(36)34-15-7-8-21(18-34)35-30-23(16-32-17-26(30)38-19(2)3)29(33-35)20-11-13-22(14-12-20)39-25-10-6-9-24(37-4)28(25)31/h5-6,9-14,16-17,19,21H,1,7-8,15,18H2,2-4H3/t21-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465363
PNG
(US10793566, Compound 2)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ccncc23)c1Cl
Show InChI InChI=1S/C27H25ClN4O3/c1-3-25(33)31-15-5-6-19(17-31)32-22-13-14-29-16-21(22)27(30-32)18-9-11-20(12-10-18)35-24-8-4-7-23(34-2)26(24)28/h3-4,7-14,16,19H,1,5-6,15,17H2,2H3/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465366
PNG
(US10793566, Compound 5)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCN(C3)C(=O)C=C)c3c(C)cncc23)c1F
Show InChI InChI=1S/C27H25FN4O3/c1-4-24(33)31-13-12-19(16-31)32-27-17(2)14-29-15-21(27)26(30-32)18-8-10-20(11-9-18)35-23-7-5-6-22(34-3)25(23)28/h4-11,14-15,19H,1,12-13,16H2,2-3H3/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444654
PNG
((R)-1-(3-(3-(4-(2,3- dimethylphenoxy)phenyl)-1H- p...)
Show SMILES Cc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ccncc23)c1C
Show InChI InChI=1S/C28H28N4O2/c1-4-27(33)31-16-6-8-22(18-31)32-25-14-15-29-17-24(25)28(30-32)21-10-12-23(13-11-21)34-26-9-5-7-19(2)20(26)3/h4-5,7,9-15,17,22H,1,6,8,16,18H2,2-3H3/t22-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444663
PNG
((R)-1-(3-(3-(4-phenoxyphenyl)-1H- pyrazolo[4,3-c]p...)
Show SMILES C=CC(=O)N1CCC[C@H](C1)n1nc(-c2ccc(Oc3ccccc3)cc2)c2cnccc12
Show InChI InChI=1S/C26H24N4O2/c1-2-25(31)29-16-6-7-20(18-29)30-24-14-15-27-17-23(24)26(28-30)19-10-12-22(13-11-19)32-21-8-4-3-5-9-21/h2-5,8-15,17,20H,1,6-7,16,18H2/t20-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444672
PNG
((S)-1-(3-(3-(4-(2,3- dichlorophenoxy)phenyl)-1H- p...)
Show SMILES Clc1cccc(Oc2ccc(cc2)-c2nn(C3CCN(C3)C(=O)C=C)c3ccncc23)c1Cl
Show InChI InChI=1S/C25H20Cl2N4O2/c1-2-23(32)30-13-11-17(15-30)31-21-10-12-28-14-19(21)25(29-31)16-6-8-18(9-7-16)33-22-5-3-4-20(26)24(22)27/h2-10,12,14,17H,1,11,13,15H2
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444691
PNG
((R)-1-(3-(3-(3-fluoro-4-phenoxyphenyl)- 1H-pyrazol...)
Show SMILES Fc1cc(ccc1Oc1ccccc1)-c1nn([C@@H]2CCN(C2)C(=O)C=C)c2ccncc12
Show InChI InChI=1S/C25H21FN4O2/c1-2-24(31)29-13-11-18(16-29)30-22-10-12-27-15-20(22)25(28-30)17-8-9-23(21(26)14-17)32-19-6-4-3-5-7-19/h2-10,12,14-15,18H,1,11,13,16H2/t18-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444698
PNG
((R)-1-(3-(3-(4-(2-chloro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCN(C3)C(=O)C=C)c3c(F)cncc23)c1Cl
Show InChI InChI=1S/C26H22ClFN4O3/c1-3-23(33)31-12-11-17(15-31)32-26-19(13-29-14-20(26)28)25(30-32)16-7-9-18(10-8-16)35-22-6-4-5-21(34-2)24(22)27/h3-10,13-14,17H,1,11-12,15H2,2H3/t17-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444701
PNG
((R)-1-(3-(3-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ccncc23)c1F
Show InChI InChI=1S/C27H25FN4O3/c1-3-25(33)31-15-5-6-19(17-31)32-22-13-14-29-16-21(22)27(30-32)18-9-11-20(12-10-18)35-24-8-4-7-23(34-2)26(24)28/h3-4,7-14,16,19H,1,5-6,15,17H2,2H3/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444706
PNG
((R)-1-(3-(7-butoxy-3-(4-(2-fluoro-3- methoxyphenox...)
Show SMILES CCCCOc1cncc2c(nn([C@@H]3CCCN(C3)C(=O)C=C)c12)-c1ccc(Oc2cccc(OC)c2F)cc1
Show InChI InChI=1S/C31H33FN4O4/c1-4-6-17-39-27-19-33-18-24-30(34-36(31(24)27)22-9-8-16-35(20-22)28(37)5-2)21-12-14-23(15-13-21)40-26-11-7-10-25(38-3)29(26)32/h5,7,10-15,18-19,22H,2,4,6,8-9,16-17,20H2,1,3H3/t22-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Blk


(Homo sapiens (Human))
BDBM465362
PNG
(US10793566, Compound 1)
Show SMILES C=CC(=O)N1CC[C@H](C1)n1nc(-c2ccc(Oc3ccccc3)cc2)c2cnccc12
Show InChI InChI=1S/C25H22N4O2/c1-2-24(30)28-15-13-19(17-28)29-23-12-14-26-16-22(23)25(27-29)18-8-10-21(11-9-18)31-20-6-4-3-5-7-20/h2-12,14,16,19H,1,13,15,17H2/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM50457316
PNG
(CHEMBL4215275 | US10662187, Compound 89 | US107935...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3c(OC)cncc23)c1F
Show InChI InChI=1S/C28H27FN4O4/c1-4-25(34)32-14-6-7-19(17-32)33-28-21(15-30-16-24(28)36-3)27(31-33)18-10-12-20(13-11-18)37-23-9-5-8-22(35-2)26(23)29/h4-5,8-13,15-16,19H,1,6-7,14,17H2,2-3H3/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444647
PNG
((R)-1-(3-(3-(4-(2,3- difluorophenoxy)phenyl)-1H- p...)
Show SMILES Fc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ccncc23)c1F
Show InChI InChI=1S/C26H22F2N4O2/c1-2-24(33)31-14-4-5-18(16-31)32-22-12-13-29-15-20(22)26(30-32)17-8-10-19(11-9-17)34-23-7-3-6-21(27)25(23)28/h2-3,6-13,15,18H,1,4-5,14,16H2/t18-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444694
PNG
((R)-1-(3-(3-(4-(3- methoxyphenoxy)phenyl)-1H- pyra...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ccncc23)c1
Show InChI InChI=1S/C26H24N4O3/c1-3-25(31)29-14-12-19(17-29)30-24-11-13-27-16-23(24)26(28-30)18-7-9-20(10-8-18)33-22-6-4-5-21(15-22)32-2/h3-11,13,15-16,19H,1,12,14,17H2,2H3/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444696
PNG
(((R)-1-(3-(7-fluoro-3-(4-phenoxyphenyl)-1H- pyrazo...)
Show SMILES Fc1cncc2c(nn([C@@H]3CCN(C3)C(=O)C=C)c12)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C25H21FN4O2/c1-2-23(31)29-13-12-18(16-29)30-25-21(14-27-15-22(25)26)24(28-30)17-8-10-20(11-9-17)32-19-6-4-3-5-7-19/h2-11,14-15,18H,1,12-13,16H2/t18-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444703
PNG
((R)-1-(3-(7-ethoxy-3-(4-(2-fluoro-3- methoxyphenox...)
Show SMILES CCOc1cncc2c(nn([C@@H]3CCCN(C3)C(=O)C=C)c12)-c1ccc(Oc2cccc(OC)c2F)cc1
Show InChI InChI=1S/C29H29FN4O4/c1-4-26(35)33-15-7-8-20(18-33)34-29-22(16-31-17-25(29)37-5-2)28(32-34)19-11-13-21(14-12-19)38-24-10-6-9-23(36-3)27(24)30/h4,6,9-14,16-17,20H,1,5,7-8,15,18H2,2-3H3/t20-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444712
PNG
((R)-1-(3-(3-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3c(O)cncc23)c1F
Show InChI InChI=1S/C27H25FN4O4/c1-3-24(34)31-13-5-6-18(16-31)32-27-20(14-29-15-21(27)33)26(30-32)17-9-11-19(12-10-17)36-23-8-4-7-22(35-2)25(23)28/h3-4,7-12,14-15,18,33H,1,5-6,13,16H2,2H3/t18-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444713
PNG
((R)-1-(3-(3-(4-(2-chloro-3- methoxyphenoxy)phenyl)...)
Show SMILES CCCOc1cncc2c(nn([C@@H]3CCCN(C3)C(=O)C=C)c12)-c1ccc(Oc2cccc(OC)c2Cl)cc1
Show InChI InChI=1S/C30H31ClN4O4/c1-4-16-38-26-18-32-17-23-29(33-35(30(23)26)21-8-7-15-34(19-21)27(36)5-2)20-11-13-22(14-12-20)39-25-10-6-9-24(37-3)28(25)31/h5-6,9-14,17-18,21H,2,4,7-8,15-16,19H2,1,3H3/t21-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444721
PNG
(1-(2-((3-(4-(2-fluoro-3- methoxyphenoxy)phenyl)-7-...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn(CC3CCCN3C(=O)C=C)c3c(OC)cncc23)c1F
Show InChI InChI=1S/C28H27FN4O4/c1-4-25(34)32-14-6-7-19(32)17-33-28-21(15-30-16-24(28)36-3)27(31-33)18-10-12-20(13-11-18)37-23-9-5-8-22(35-2)26(23)29/h4-5,8-13,15-16,19H,1,6-7,14,17H2,2-3H3
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444729
PNG
(1-((3R)-3-(3-(4-(2-fluoro-3- methoxyphenoxy)phenyl...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3c(OC4CCOC4)cncc23)c1F
Show InChI InChI=1S/C31H31FN4O5/c1-3-28(37)35-14-5-6-21(18-35)36-31-24(16-33-17-27(31)41-23-13-15-39-19-23)30(34-36)20-9-11-22(12-10-20)40-26-8-4-7-25(38-2)29(26)32/h3-4,7-12,16-17,21,23H,1,5-6,13-15,18-19H2,2H3/t21-,23?/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465362
PNG
(US10793566, Compound 1)
Show SMILES C=CC(=O)N1CC[C@H](C1)n1nc(-c2ccc(Oc3ccccc3)cc2)c2cnccc12
Show InChI InChI=1S/C25H22N4O2/c1-2-24(30)28-15-13-19(17-28)29-23-12-14-26-16-22(23)25(27-29)18-8-10-21(11-9-18)31-20-6-4-3-5-7-20/h2-12,14,16,19H,1,13,15,17H2/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465362
PNG
(US10793566, Compound 1)
Show SMILES C=CC(=O)N1CC[C@H](C1)n1nc(-c2ccc(Oc3ccccc3)cc2)c2cnccc12
Show InChI InChI=1S/C25H22N4O2/c1-2-24(30)28-15-13-19(17-28)29-23-12-14-26-16-22(23)25(27-29)18-8-10-21(11-9-18)31-20-6-4-3-5-7-20/h2-12,14,16,19H,1,13,15,17H2/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444649
PNG
((R)-1-(3-(3-(4-(3-chloro-2- fluorophenoxy)phenyl)-...)
Show SMILES Fc1c(Cl)cccc1Oc1ccc(cc1)-c1nn([C@@H]2CCN(C2)C(=O)C=C)c2ccncc12
Show InChI InChI=1S/C25H20ClFN4O2/c1-2-23(32)30-13-11-17(15-30)31-21-10-12-28-14-19(21)25(29-31)16-6-8-18(9-7-16)33-22-5-3-4-20(26)24(22)27/h2-10,12,14,17H,1,11,13,15H2/t17-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444692
PNG
((R)-1-(3-(3-(4-(3-fluorophenoxy)phenyl)- 1H-pyrazo...)
Show SMILES Fc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ccncc23)c1
Show InChI InChI=1S/C26H23FN4O2/c1-2-25(32)30-14-4-6-20(17-30)31-24-12-13-28-16-23(24)26(29-31)18-8-10-21(11-9-18)33-22-7-3-5-19(27)15-22/h2-3,5,7-13,15-16,20H,1,4,6,14,17H2/t20-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444711
PNG
((R)-1-(3-(3-(4-(2-chloro-3- methoxyphenoxy)phenyl)...)
Show SMILES CCOc1cncc2c(nn([C@@H]3CCCN(C3)C(=O)C=C)c12)-c1ccc(Oc2cccc(OC)c2Cl)cc1
Show InChI InChI=1S/C29H29ClN4O4/c1-4-26(35)33-15-7-8-20(18-33)34-29-22(16-31-17-25(29)37-5-2)28(32-34)19-11-13-21(14-12-19)38-24-10-6-9-23(36-3)27(24)30/h4,6,9-14,16-17,20H,1,5,7-8,15,18H2,2-3H3/t20-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444641
PNG
((R)-1-(3-(3-(3-chloro-4-phenoxyphenyl)- 1H-pyrazol...)
Show SMILES Clc1cc(ccc1Oc1ccccc1)-c1nn([C@@H]2CCN(C2)C(=O)C=C)c2ccncc12
Show InChI InChI=1S/C25H21ClN4O2/c1-2-24(31)29-13-11-18(16-29)30-22-10-12-27-15-20(22)25(28-30)17-8-9-23(21(26)14-17)32-19-6-4-3-5-7-19/h2-10,12,14-15,18H,1,11,13,16H2/t18-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444643
PNG
((R)-1-(3-(3-(4-(2-chloro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ccncc23)c1Cl
Show InChI InChI=1S/C26H23ClN4O3/c1-3-24(32)30-14-12-18(16-30)31-21-11-13-28-15-20(21)26(29-31)17-7-9-19(10-8-17)34-23-6-4-5-22(33-2)25(23)27/h3-11,13,15,18H,1,12,14,16H2,2H3/t18-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444656
PNG
(1-(6-(3-(4-(2-fluoro-3- methoxyphenoxy)phenyl)-1H-...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn(C3CC4(C3)CN(C4)C(=O)C=C)c3ccncc23)c1F
Show InChI InChI=1S/C28H25FN4O3/c1-3-25(34)32-16-28(17-32)13-19(14-28)33-22-11-12-30-15-21(22)27(31-33)18-7-9-20(10-8-18)36-24-6-4-5-23(35-2)26(24)29/h3-12,15,19H,1,13-14,16-17H2,2H3
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444693
PNG
((R)-1-(3-(3-(4-(3-fluorophenoxy)phenyl)- 1H-pyrazo...)
Show SMILES Fc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ccncc23)c1
Show InChI InChI=1S/C25H21FN4O2/c1-2-24(31)29-13-11-19(16-29)30-23-10-12-27-15-22(23)25(28-30)17-6-8-20(9-7-17)32-21-5-3-4-18(26)14-21/h2-10,12,14-15,19H,1,11,13,16H2/t19-/m1/s1
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n/an/a<10n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM50457316
PNG
(CHEMBL4215275 | US10662187, Compound 89 | US107935...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3c(OC)cncc23)c1F
Show InChI InChI=1S/C28H27FN4O4/c1-4-25(34)32-14-6-7-19(17-32)33-28-21(15-30-16-24(28)36-3)27(31-33)18-10-12-20(13-11-18)37-23-9-5-8-22(35-2)26(23)29/h4-5,8-13,15-16,19H,1,6-7,14,17H2,2-3H3/t19-/m1/s1
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n/an/a<10n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444731
PNG
((R)-1-(3-(3-(4-((2- fluorobenzyl)oxy)phenyl)-1H- p...)
Show SMILES Fc1ccccc1COc1ccc(cc1)-c1nn([C@@H]2CCCN(C2)C(=O)C=C)c2ccncc12
Show InChI InChI=1S/C27H25FN4O2/c1-2-26(33)31-15-5-7-21(17-31)32-25-13-14-29-16-23(25)27(30-32)19-9-11-22(12-10-19)34-18-20-6-3-4-8-24(20)28/h2-4,6,8-14,16,21H,1,5,7,15,17-18H2/t21-/m1/s1
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n/an/a 55n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM50457317
PNG
(CHEMBL4214322 | US10662187, Compound 9 | US1079356...)
Show SMILES Clc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ccncc23)c1
Show InChI InChI=1S/C26H23ClN4O2/c1-2-25(32)30-14-4-6-20(17-30)31-24-12-13-28-16-23(24)26(29-31)18-8-10-21(11-9-18)33-22-7-3-5-19(27)15-22/h2-3,5,7-13,15-16,20H,1,4,6,14,17H2/t20-/m1/s1
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n/an/a 55n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444646
PNG
((R)-1-(3-(3-(4-(3-fluoro-2- methylphenoxy)phenyl)-...)
Show SMILES Cc1c(F)cccc1Oc1ccc(cc1)-c1nn([C@@H]2CCCN(C2)C(=O)C=C)c2ccncc12
Show InChI InChI=1S/C27H25FN4O2/c1-3-26(33)31-15-5-6-20(17-31)32-24-13-14-29-16-22(24)27(30-32)19-9-11-21(12-10-19)34-25-8-4-7-23(28)18(25)2/h3-4,7-14,16,20H,1,5-6,15,17H2,2H3/t20-/m1/s1
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n/an/a 55n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444652
PNG
(N-(3-(3-(4-phenoxyphenyl)-1H- pyrazolo[4,3-c]pyrid...)
Show SMILES C=CC(=O)Nc1cccc(c1)-n1nc(-c2ccc(Oc3ccccc3)cc2)c2cnccc12
Show InChI InChI=1S/C27H20N4O2/c1-2-26(32)29-20-7-6-8-21(17-20)31-25-15-16-28-18-24(25)27(30-31)19-11-13-23(14-12-19)33-22-9-4-3-5-10-22/h2-18H,1H2,(H,29,32)
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444681
PNG
((R)-1-(3-(3-(3-fluoro-4-phenoxyphenyl)- 1H-pyrazol...)
Show SMILES Fc1cc(ccc1Oc1ccccc1)-c1nn([C@@H]2CCCN(C2)C(=O)C=C)c2ccncc12
Show InChI InChI=1S/C26H23FN4O2/c1-2-25(32)30-14-6-7-19(17-30)31-23-12-13-28-16-21(23)26(29-31)18-10-11-24(22(27)15-18)33-20-8-4-3-5-9-20/h2-5,8-13,15-16,19H,1,6-7,14,17H2/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444686
PNG
((R)-1-(3-(3-(4-(3-chloro-2- methylphenoxy)phenyl)-...)
Show SMILES Cc1c(Cl)cccc1Oc1ccc(cc1)-c1nn([C@@H]2CCCN(C2)C(=O)C=C)c2ccncc12
Show InChI InChI=1S/C27H25ClN4O2/c1-3-26(33)31-15-5-6-20(17-31)32-24-13-14-29-16-22(24)27(30-32)19-9-11-21(12-10-19)34-25-8-4-7-23(28)18(25)2/h3-4,7-14,16,20H,1,5-6,15,17H2,2H3/t20-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444702
PNG
((R)-1-(3-(7-(difluoromethyl)-3-(4-(2-fluoro-3- met...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3c(cncc23)C(F)F)c1F
Show InChI InChI=1S/C28H25F3N4O3/c1-3-24(36)34-13-5-6-18(16-34)35-27-20(14-32-15-21(27)28(30)31)26(33-35)17-9-11-19(12-10-17)38-23-8-4-7-22(37-2)25(23)29/h3-4,7-12,14-15,18,28H,1,5-6,13,16H2,2H3/t18-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444717
PNG
((R)-1-(3-(7-(2-aminoethoxy)-3-(4-(2-fluoro- 3-meth...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C(=O)C=C)c3c(OCCN)cncc23)c1F
Show InChI InChI=1S/C29H30FN5O4/c1-3-26(36)34-14-5-6-20(18-34)35-29-22(16-32-17-25(29)38-15-13-31)28(33-35)19-9-11-21(12-10-19)39-24-8-4-7-23(37-2)27(24)30/h3-4,7-12,16-17,20H,1,5-6,13-15,18,31H2,2H3
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n/an/a 55n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444718
PNG
((R)-1-(3-(3-(4-(3-methoxy-2- propoxyphenoxy)phenyl...)
Show SMILES CCCOc1cncc2c(nn(C3CCCN(C3)C(=O)C=C)c12)-c1ccc(Oc2cccc(OC)c2OCCC)cc1
Show InChI InChI=1S/C33H38N4O5/c1-5-18-40-29-21-34-20-26-31(35-37(32(26)29)24-10-9-17-36(22-24)30(38)7-3)23-13-15-25(16-14-23)42-28-12-8-11-27(39-4)33(28)41-19-6-2/h7-8,11-16,20-21,24H,3,5-6,9-10,17-19,22H2,1-2,4H3
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444725
PNG
((S)-1-(3-(3-(4-(1-phenylvinyl)phenyl)-1H- pyrazolo...)
Show SMILES C=CC(=O)N1CCCC(C1)n1nc(-c2ccc(cc2)C(=C)c2ccccc2)c2cnccc12
Show InChI InChI=1S/C28H26N4O/c1-3-27(33)31-17-7-10-24(19-31)32-26-15-16-29-18-25(26)28(30-32)23-13-11-22(12-14-23)20(2)21-8-5-4-6-9-21/h3-6,8-9,11-16,18,24H,1-2,7,10,17,19H2
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444740
PNG
((R)-1-(3-(3-(4-([1,4'-bipiperidin]-1'- yl)phenyl)-...)
Show SMILES C=CC(=O)N1CCCC(C1)n1nc(-c2ccc(cc2)N2CCC(CC2)N2CCCCC2)c2cnccc12
Show InChI InChI=1S/C30H38N6O/c1-2-29(37)35-18-6-7-26(22-35)36-28-12-15-31-21-27(28)30(32-36)23-8-10-24(11-9-23)34-19-13-25(14-20-34)33-16-4-3-5-17-33/h2,8-12,15,21,25-26H,1,3-7,13-14,16-20,22H2
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444662
PNG
((R)-1-(3-(3-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@H]3CCN(C3)C(=O)C=C)c3ccncc23)c1F
Show InChI InChI=1S/C26H23FN4O3/c1-3-24(32)30-14-12-18(16-30)31-21-11-13-28-15-20(21)26(29-31)17-7-9-19(10-8-17)34-23-6-4-5-22(33-2)25(23)27/h3-11,13,15,18H,1,12,14,16H2,2H3/t18-/m0/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444679
PNG
((R)-1-(3-(3-(4-(3-fluoro-2- methoxyphenoxy)phenyl)...)
Show SMILES COc1c(F)cccc1Oc1ccc(cc1)-c1nn([C@@H]2CCN(C2)C(=O)C=C)c2ccncc12
Show InChI InChI=1S/C26H23FN4O3/c1-3-24(32)30-14-12-18(16-30)31-22-11-13-28-15-20(22)25(29-31)17-7-9-19(10-8-17)34-23-6-4-5-21(27)26(23)33-2/h3-11,13,15,18H,1,12,14,16H2,2H3/t18-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM50457319
PNG
(CHEMBL4205974 | US10662187, Compound 59 | US107935...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ccncc23)c1C
Show InChI InChI=1S/C27H26N4O3/c1-4-26(32)30-15-13-20(17-30)31-23-12-14-28-16-22(23)27(29-31)19-8-10-21(11-9-19)34-25-7-5-6-24(33-3)18(25)2/h4-12,14,16,20H,1,13,15,17H2,2-3H3/t20-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465482
PNG
((3R)-3-(3-(4-(2-fluoro-3- methoxyphenoxy)phenyl)- ...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C(O)=O)c3c(OC)cncc23)c1F
Show InChI InChI=1S/C26H25FN4O5/c1-34-20-6-3-7-21(23(20)27)36-18-10-8-16(9-11-18)24-19-13-28-14-22(35-2)25(19)31(29-24)17-5-4-12-30(15-17)26(32)33/h3,6-11,13-14,17H,4-5,12,15H2,1-2H3,(H,32,33)
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Blk


(Homo sapiens (Human))
BDBM50457316
PNG
(CHEMBL4215275 | US10662187, Compound 89 | US107935...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3c(OC)cncc23)c1F
Show InChI InChI=1S/C28H27FN4O4/c1-4-25(34)32-14-6-7-19(17-32)33-28-21(15-30-16-24(28)36-3)27(31-33)18-10-12-20(13-11-18)37-23-9-5-8-22(35-2)26(23)29/h4-5,8-13,15-16,19H,1,6-7,14,17H2,2-3H3/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444637
PNG
((R)-1-(3-(3-(4-(naphthalen-1- yloxy)phenyl)-1H-pyr...)
Show SMILES C=CC(=O)N1CC[C@H](C1)n1nc(-c2ccc(Oc3cccc4ccccc34)cc2)c2cnccc12
Show InChI InChI=1S/C29H24N4O2/c1-2-28(34)32-17-15-22(19-32)33-26-14-16-30-18-25(26)29(31-33)21-10-12-23(13-11-21)35-27-9-5-7-20-6-3-4-8-24(20)27/h2-14,16,18,22H,1,15,17,19H2/t22-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444642
PNG
((R)-1-(3-(3-(4-(2,3- dimethylphenoxy)phenyl)-1H- p...)
Show SMILES Cc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ccncc23)c1C
Show InChI InChI=1S/C27H26N4O2/c1-4-26(32)30-15-13-21(17-30)31-24-12-14-28-16-23(24)27(29-31)20-8-10-22(11-9-20)33-25-7-5-6-18(2)19(25)3/h4-12,14,16,21H,1,13,15,17H2,2-3H3/t21-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444659
PNG
((R)-1-(3-(3-(4-(cyclohexyloxy)phenyl)- 1H-pyrazolo...)
Show SMILES C=CC(=O)N1CCC[C@H](C1)n1nc(-c2ccc(OC3CCCCC3)cc2)c2cnccc12
Show InChI InChI=1S/C26H30N4O2/c1-2-25(31)29-16-6-7-20(18-29)30-24-14-15-27-17-23(24)26(28-30)19-10-12-22(13-11-19)32-21-8-4-3-5-9-21/h2,10-15,17,20-21H,1,3-9,16,18H2/t20-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444690
PNG
((R)-1-(3-(3-(4-(3-chloro-2- methylphenoxy)phenyl)-...)
Show SMILES Cc1c(Cl)cccc1Oc1ccc(cc1)-c1nn([C@@H]2CCN(C2)C(=O)C=C)c2ccncc12
Show InChI InChI=1S/C26H23ClN4O2/c1-3-25(32)30-14-12-19(16-30)31-23-11-13-28-15-21(23)26(29-31)18-7-9-20(10-8-18)33-24-6-4-5-22(27)17(24)2/h3-11,13,15,19H,1,12,14,16H2,2H3/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444722
PNG
((E)-2-(2-((3-(4-(2-fluoro-3- methoxyphenoxy)phenyl...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn(CC3CCCN3C(=O)C(=C\C(C)(C)C)\C#N)c3c(OC)cncc23)c1F
Show InChI InChI=1S/C33H34FN5O4/c1-33(2,3)16-22(17-35)32(40)38-15-7-8-23(38)20-39-31-25(18-36-19-28(31)42-5)30(37-39)21-11-13-24(14-12-21)43-27-10-6-9-26(41-4)29(27)34/h6,9-14,16,18-19,23H,7-8,15,20H2,1-5H3/b22-16+
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465463
PNG
((R)-1-(3-(3-(4- (phenoxymethyl)phenyl)- 1H-indazol...)
Show SMILES C=CC(=O)N1CCCC(C1)n1nc(-c2ccc(OCc3ccccc3)cc2)c2cnccc12
Show InChI InChI=1S/C27H26N4O2/c1-2-26(32)30-16-6-9-22(18-30)31-25-14-15-28-17-24(25)27(29-31)21-10-12-23(13-11-21)33-19-20-7-4-3-5-8-20/h2-5,7-8,10-15,17,22H,1,6,9,16,18-19H2
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444737
PNG
((R)-1-(3-(3-(3'-methyl-[1,1'-biphenyl]- 4-yl)-1H-p...)
Show SMILES Cc1cccc(c1)-c1ccc(cc1)-c1nn([C@@H]2CCN(C2)C(=O)C=C)c2ccncc12
Show InChI InChI=1S/C26H24N4O/c1-3-25(31)29-14-12-22(17-29)30-24-11-13-27-16-23(24)26(28-30)20-9-7-19(8-10-20)21-6-4-5-18(2)15-21/h3-11,13,15-16,22H,1,12,14,17H2,2H3/t22-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444747
PNG
((R)-N-(4-(1-(1-acryloylpiperidin-3- yl)-1H-pyrazol...)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1ccc(cc1)-c1nn([C@@H]2CCCN(C2)C(=O)C=C)c2ccncc12
Show InChI InChI=1S/C28H24F3N5O2/c1-2-25(37)35-14-4-7-22(17-35)36-24-12-13-32-16-23(24)26(34-36)18-8-10-21(11-9-18)33-27(38)19-5-3-6-20(15-19)28(29,30)31/h2-3,5-6,8-13,15-16,22H,1,4,7,14,17H2,(H,33,38)/t22-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444661
PNG
((R)-1-(3-(3-(4-((2,3-dihydro-1H-inden-4- yl)oxy)ph...)
Show SMILES C=CC(=O)N1CC[C@H](C1)n1nc(-c2ccc(Oc3cccc4CCCc34)cc2)c2cnccc12
Show InChI InChI=1S/C28H26N4O2/c1-2-27(33)31-16-14-21(18-31)32-25-13-15-29-17-24(25)28(30-32)20-9-11-22(12-10-20)34-26-8-4-6-19-5-3-7-23(19)26/h2,4,6,8-13,15,17,21H,1,3,5,7,14,16,18H2/t21-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444665
PNG
((S)-1-(3-(3-(3-chloro-4-phenoxyphenyl)- 1H-pyrazol...)
Show SMILES Clc1cc(ccc1Oc1ccccc1)-c1nn(C2CCCN(C2)C(=O)C=C)c2ccncc12
Show InChI InChI=1S/C26H23ClN4O2/c1-2-25(32)30-14-6-7-19(17-30)31-23-12-13-28-16-21(23)26(29-31)18-10-11-24(22(27)15-18)33-20-8-4-3-5-9-20/h2-5,8-13,15-16,19H,1,6-7,14,17H2
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444678
PNG
((R)-1-(3-(3-(4-(2-fluoro-3- methylphenoxy)phenyl)-...)
Show SMILES Cc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ccncc23)c1F
Show InChI InChI=1S/C27H25FN4O2/c1-3-25(33)31-15-5-7-20(17-31)32-23-13-14-29-16-22(23)27(30-32)19-9-11-21(12-10-19)34-24-8-4-6-18(2)26(24)28/h3-4,6,8-14,16,20H,1,5,7,15,17H2,2H3/t20-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444680
PNG
((R)-1-(3-(3-(4-(3-fluoro-2- methoxyphenoxy)phenyl)...)
Show SMILES COc1c(F)cccc1Oc1ccc(cc1)-c1nn([C@@H]2CCCN(C2)C(=O)C=C)c2ccncc12
Show InChI InChI=1S/C27H25FN4O3/c1-3-25(33)31-15-5-6-19(17-31)32-23-13-14-29-16-21(23)26(30-32)18-9-11-20(12-10-18)35-24-8-4-7-22(28)27(24)34-2/h3-4,7-14,16,19H,1,5-6,15,17H2,2H3/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444682
PNG
(1-(3-(3-(4-phenoxyphenyl)-1H- pyrazolo[4,3-c]pyrid...)
Show SMILES C=CC(=O)N1CC(C1)n1nc(-c2ccc(Oc3ccccc3)cc2)c2cnccc12
Show InChI InChI=1S/C24H20N4O2/c1-2-23(29)27-15-18(16-27)28-22-12-13-25-14-21(22)24(26-28)17-8-10-20(11-9-17)30-19-6-4-3-5-7-19/h2-14,18H,1,15-16H2
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444684
PNG
((R)-1-(3-(4-amino-3-(4-phenoxyphenyl)- 1H-indazol-...)
Show SMILES Nc1cccc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C26H24N4O2/c1-2-24(31)29-16-15-19(17-29)30-23-10-6-9-22(27)25(23)26(28-30)18-11-13-21(14-12-18)32-20-7-4-3-5-8-20/h2-14,19H,1,15-17,27H2/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444685
PNG
((R)-1-(3-(4-amino-3-(4-phenoxyphenyl)- 1H-indazol-...)
Show SMILES Nc1cccc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C27H26N4O2/c1-2-25(32)30-17-7-8-20(18-30)31-24-12-6-11-23(28)26(24)27(29-31)19-13-15-22(16-14-19)33-21-9-4-3-5-10-21/h2-6,9-16,20H,1,7-8,17-18,28H2/t20-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444746
PNG
(US10662187, Compound 116 | US10793566, Compound 11...)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1ccc(cc1)-c1nn(C2CCN(C2)C(=O)C=C)c2ccncc12
Show InChI InChI=1S/C27H22F3N5O2/c1-2-24(36)34-13-11-21(16-34)35-23-10-12-31-15-22(23)25(33-35)17-6-8-20(9-7-17)32-26(37)18-4-3-5-19(14-18)27(28,29)30/h2-10,12,14-15,21H,1,11,13,16H2,(H,32,37)
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465479
PNG
(1-((R)-3-(3-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C(=O)C(C)O)c3c(OC)cncc23)c1F
Show InChI InChI=1S/C28H29FN4O5/c1-17(34)28(35)32-13-5-6-19(16-32)33-27-21(14-30-15-24(27)37-3)26(31-33)18-9-11-20(12-10-18)38-23-8-4-7-22(36-2)25(23)29/h4,7-12,14-15,17,19,34H,5-6,13,16H2,1-3H3
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444749
PNG
((R)-2-(3-(3-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C(=O)C(O)=O)c3c(OC)cncc23)c1F
Show InChI InChI=1S/C27H25FN4O6/c1-36-20-6-3-7-21(23(20)28)38-18-10-8-16(9-11-18)24-19-13-29-14-22(37-2)25(19)32(30-24)17-5-4-12-31(15-17)26(33)27(34)35/h3,6-11,13-14,17H,4-5,12,15H2,1-2H3,(H,34,35)
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444750
PNG
((R)-2-(3-(3-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C(=O)C(N)=O)c3c(OC)cncc23)c1F
Show InChI InChI=1S/C27H26FN5O5/c1-36-20-6-3-7-21(23(20)28)38-18-10-8-16(9-11-18)24-19-13-30-14-22(37-2)25(19)33(31-24)17-5-4-12-32(15-17)27(35)26(29)34/h3,6-11,13-14,17H,4-5,12,15H2,1-2H3,(H2,29,34)
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n/an/a 55n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444644
PNG
((R)-1-(3-(3-(4-(3-fluoro-2- methylphenoxy)phenyl)-...)
Show SMILES Cc1c(F)cccc1Oc1ccc(cc1)-c1nn([C@@H]2CCN(C2)C(=O)C=C)c2ccncc12
Show InChI InChI=1S/C26H23FN4O2/c1-3-25(32)30-14-12-19(16-30)31-23-11-13-28-15-21(23)26(29-31)18-7-9-20(10-8-18)33-24-6-4-5-22(27)17(24)2/h3-11,13,15,19H,1,12,14,16H2,2H3/t19-/m1/s1
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n/an/a 55n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444651
PNG
(1-(3-((3-(4-phenoxyphenyl)-1H- pyrazolo[4,3-c]pyri...)
Show SMILES C=CC(=O)N1CCC(Cn2nc(-c3ccc(Oc4ccccc4)cc3)c3cnccc23)C1
Show InChI InChI=1S/C26H24N4O2/c1-2-25(31)29-15-13-19(17-29)18-30-24-12-14-27-16-23(24)26(28-30)20-8-10-22(11-9-20)32-21-6-4-3-5-7-21/h2-12,14,16,19H,1,13,15,17-18H2
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n/an/a 55n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444653
PNG
((R)-1-(3-(3-(4-(3- isopropoxyphenoxy)phenyl)-1H- p...)
Show SMILES CC(C)Oc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ccncc23)c1
Show InChI InChI=1S/C29H30N4O3/c1-4-28(34)32-16-6-7-22(19-32)33-27-14-15-30-18-26(27)29(31-33)21-10-12-23(13-11-21)36-25-9-5-8-24(17-25)35-20(2)3/h4-5,8-15,17-18,20,22H,1,6-7,16,19H2,2-3H3/t22-/m1/s1
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n/an/a 55n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444657
PNG
((R)-1-(3-(7-chloro-3-(4-(2-fluoro-3- methoxyphenox...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCN(C3)C(=O)C=C)c3c(Cl)cncc23)c1F
Show InChI InChI=1S/C26H22ClFN4O3/c1-3-23(33)31-12-11-17(15-31)32-26-19(13-29-14-20(26)27)25(30-32)16-7-9-18(10-8-16)35-22-6-4-5-21(34-2)24(22)28/h3-10,13-14,17H,1,11-12,15H2,2H3/t17-/m1/s1
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n/an/a 55n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444666
PNG
((S)-1-(3-(3-(4-(3-chlorophenoxy)phenyl)- 1H-pyrazo...)
Show SMILES Clc1cccc(Oc2ccc(cc2)-c2nn(C3CCN(C3)C(=O)C=C)c3ccncc23)c1
Show InChI InChI=1S/C25H21ClN4O2/c1-2-24(31)29-13-11-19(16-29)30-23-10-12-27-15-22(23)25(28-30)17-6-8-20(9-7-17)32-21-5-3-4-18(26)14-21/h2-10,12,14-15,19H,1,11,13,16H2
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444667
PNG
((S)-1-(3-(3-(4-(m-tolyloxy)phenyl)-1H- pyrazolo[4,...)
Show SMILES Cc1cccc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C(=O)C=C)c3ccncc23)c1
Show InChI InChI=1S/C27H26N4O2/c1-3-26(32)30-15-5-7-21(18-30)31-25-13-14-28-17-24(25)27(29-31)20-9-11-22(12-10-20)33-23-8-4-6-19(2)16-23/h3-4,6,8-14,16-17,21H,1,5,7,15,18H2,2H3
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444670
PNG
((S)-1-(3-(3-(4-(2-chloro-3- fluorophenoxy)phenyl)-...)
Show SMILES Fc1cccc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C(=O)C=C)c3ccncc23)c1Cl
Show InChI InChI=1S/C26H22ClFN4O2/c1-2-24(33)31-14-4-5-18(16-31)32-22-12-13-29-15-20(22)26(30-32)17-8-10-19(11-9-17)34-23-7-3-6-21(28)25(23)27/h2-3,6-13,15,18H,1,4-5,14,16H2
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444724
PNG
((R)-1-(3-(7-(2-(dimethylamino)ethoxy)-3-(4- (2-flu...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C#CC)c3c(OCCN(C)C)cncc23)c1F
Show InChI InChI=1S/C32H34FN5O4/c1-5-8-29(39)37-16-7-9-23(21-37)38-32-25(19-34-20-28(32)41-18-17-36(2)3)31(35-38)22-12-14-24(15-13-22)42-27-11-6-10-26(40-4)30(27)33/h6,10-15,19-20,23H,7,9,16-18,21H2,1-4H3/t23-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444726
PNG
((R)-1-(3-(3-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3c(OC(C)C)cncc23)c1F
Show InChI InChI=1S/C30H31FN4O4/c1-5-27(36)34-15-7-8-21(18-34)35-30-23(16-32-17-26(30)38-19(2)3)29(33-35)20-11-13-22(14-12-20)39-25-10-6-9-24(37-4)28(25)31/h5-6,9-14,16-17,19,21H,1,7-8,15,18H2,2-4H3/t21-/m1/s1
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n/an/a 55n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444731
PNG
((R)-1-(3-(3-(4-((2- fluorobenzyl)oxy)phenyl)-1H- p...)
Show SMILES Fc1ccccc1COc1ccc(cc1)-c1nn([C@@H]2CCCN(C2)C(=O)C=C)c2ccncc12
Show InChI InChI=1S/C27H25FN4O2/c1-2-26(33)31-15-5-7-21(17-31)32-25-13-14-29-16-23(25)27(30-32)19-9-11-22(12-10-19)34-18-20-6-3-4-8-24(20)28/h2-4,6,8-14,16,21H,1,5,7,15,17-18H2/t21-/m1/s1
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n/an/a 55n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444695
PNG
((R)-1-(3-(3-(4-(3- methoxyphenoxy)phenyl)-1H- pyra...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ccncc23)c1
Show InChI InChI=1S/C27H26N4O3/c1-3-26(32)30-15-5-6-20(18-30)31-25-13-14-28-17-24(25)27(29-31)19-9-11-21(12-10-19)34-23-8-4-7-22(16-23)33-2/h3-4,7-14,16-17,20H,1,5-6,15,18H2,2H3/t20-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444668
PNG
((R)-1-(3-(3-(4-(2-chloro-3- fluorophenoxy)phenyl)-...)
Show SMILES Fc1cccc(Oc2ccc(cc2)-c2n(nc3ccncc23)C2CCN(C2)C(=O)C=C)c1Cl
Show InChI InChI=1S/C25H20ClFN4O2/c1-2-23(32)30-13-11-17(15-30)31-25(19-14-28-12-10-21(19)29-31)16-6-8-18(9-7-16)33-22-5-3-4-20(27)24(22)26/h2-10,12,14,17H,1,11,13,15H2
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444669
PNG
((R)-1-(3-(3-(4-(2-chloro-3- fluorophenoxy)phenyl)-...)
Show SMILES Fc1cccc(Oc2ccc(cc2)-c2n(nc3ccncc23)C2CCCN(C2)C(=O)C=C)c1Cl
Show InChI InChI=1S/C26H22ClFN4O2/c1-2-24(33)31-14-4-5-18(16-31)32-26(20-15-29-13-12-22(20)30-32)17-8-10-19(11-9-17)34-23-7-3-6-21(28)25(23)27/h2-3,6-13,15,18H,1,4-5,14,16H2
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444683
PNG
(1-(3-((3-(4-phenoxyphenyl)-1H- pyrazolo[4,3-c]pyri...)
Show SMILES C=CC(=O)N1CCCC(Cn2nc(-c3ccc(Oc4ccccc4)cc3)c3cnccc23)C1
Show InChI InChI=1S/C27H26N4O2/c1-2-26(32)30-16-6-7-20(18-30)19-31-25-14-15-28-17-24(25)27(29-31)21-10-12-23(13-11-21)33-22-8-4-3-5-9-22/h2-5,8-15,17,20H,1,6-7,16,18-19H2
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444687
PNG
((R)-1-(3-(3-(4-(3-methoxy-2- methylphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ccncc23)c1C
Show InChI InChI=1S/C28H28N4O3/c1-4-27(33)31-16-6-7-21(18-31)32-24-14-15-29-17-23(24)28(30-32)20-10-12-22(13-11-20)35-26-9-5-8-25(34-3)19(26)2/h4-5,8-15,17,21H,1,6-7,16,18H2,2-3H3/t21-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444640
PNG
((R)-1-(3-(3-(4-(m-tolyloxy)phenyl)-1H- pyrazolo[4,...)
Show SMILES Cc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ccncc23)c1
Show InChI InChI=1S/C26H24N4O2/c1-3-25(31)29-14-12-20(17-29)30-24-11-13-27-16-23(24)26(28-30)19-7-9-21(10-8-19)32-22-6-4-5-18(2)15-22/h3-11,13,15-16,20H,1,12,14,17H2,2H3/t20-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465451
PNG
((R,E)-2-(3-(3-(4-(2-fluoro-3- methoxyphenoxy)pheny...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C(=O)C(=C\C(C)(C)C)\C#N)c3c(OC)cncc23)c1F
Show InChI InChI=1S/C33H34FN5O4/c1-33(2,3)16-22(17-35)32(40)38-15-7-8-23(20-38)39-31-25(18-36-19-28(31)42-5)30(37-39)21-11-13-24(14-12-21)43-27-10-6-9-26(41-4)29(27)34/h6,9-14,16,18-19,23H,7-8,15,20H2,1-5H3/b22-16+
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444664
PNG
((S)-1-(3-(3-(4-((3- chlorophenyl)thio)phenyl)-1H- ...)
Show SMILES Clc1cccc(Sc2ccc(cc2)-c2nn(C3CCN(C3)C(=O)C=C)c3ccncc23)c1
Show InChI InChI=1S/C25H21ClN4OS/c1-2-24(31)29-13-11-19(16-29)30-23-10-12-27-15-22(23)25(28-30)17-6-8-20(9-7-17)32-21-5-3-4-18(26)14-21/h2-10,12,14-15,19H,1,11,13,16H2
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465474
PNG
((R)-1-(3-(3-(2-methoxy-4-(4- methylpiperazin-1-yl)...)
Show SMILES COc1cc(ccc1-c1nn(C2CCCN(C2)C(=O)C=C)c2ccncc12)N1CCN(C)CC1
Show InChI InChI=1S/C26H32N6O2/c1-4-25(33)31-11-5-6-20(18-31)32-23-9-10-27-17-22(23)26(28-32)21-8-7-19(16-24(21)34-3)30-14-12-29(2)13-15-30/h4,7-10,16-17,20H,1,5-6,11-15,18H2,2-3H3
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n/an/a 550n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM50457315
PNG
(CHEMBL4210340 | US10662187, Compound 105 | US10793...)
Show SMILES CC#CC(=O)N1CCC[C@H](C1)n1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2cnccc12
Show InChI InChI=1S/C27H24N6O2/c1-2-6-25(34)32-16-5-7-21(18-32)33-23-13-15-28-17-22(23)26(31-33)19-9-11-20(12-10-19)27(35)30-24-8-3-4-14-29-24/h3-4,8-15,17,21H,5,7,16,18H2,1H3,(H,29,30,35)/t21-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM465362
PNG
(US10793566, Compound 1)
Show SMILES C=CC(=O)N1CC[C@H](C1)n1nc(-c2ccc(Oc3ccccc3)cc2)c2cnccc12
Show InChI InChI=1S/C25H22N4O2/c1-2-24(30)28-15-13-19(17-28)29-23-12-14-26-16-22(23)25(27-29)18-8-10-21(11-9-18)31-20-6-4-3-5-7-20/h2-12,14,16,19H,1,13,15,17H2/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444704
PNG
((R)-(3-(3-(4-(2-fluoro-3- methoxyphenoxy)phenyl)-7...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C(=O)C3CC4(C3)CN(C4)S(=O)(=O)c3ccc(C)cc3)c3c(OC)cncc23)c1F
Show InChI InChI=1S/C39H40FN5O6S/c1-25-9-15-30(16-10-25)52(47,48)44-23-39(24-44)18-27(19-39)38(46)43-17-5-6-28(22-43)45-37-31(20-41-21-34(37)50-3)36(42-45)26-11-13-29(14-12-26)51-33-8-4-7-32(49-2)35(33)40/h4,7-16,20-21,27-28H,5-6,17-19,22-24H2,1-3H3
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444734
PNG
((R)-4-(1-(1-acryloylpiperidin-3- yl)-1H-pyrazolo[4...)
Show SMILES COc1cccc(CNC(=O)c2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ccncc23)c1
Show InChI InChI=1S/C29H29N5O3/c1-3-27(35)33-15-5-7-23(19-33)34-26-13-14-30-18-25(26)28(32-34)21-9-11-22(12-10-21)29(36)31-17-20-6-4-8-24(16-20)37-2/h3-4,6,8-14,16,18,23H,1,5,7,15,17,19H2,2H3,(H,31,36)/t23-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444638
PNG
((R)-1-(3-(3-(4-(benzo[d][1,3]dioxol-4- yloxy)pheny...)
Show SMILES C=CC(=O)N1CCC[C@H](C1)n1nc(-c2ccc(Oc3cccc4OCOc34)cc2)c2cnccc12
Show InChI InChI=1S/C27H24N4O4/c1-2-25(32)30-14-4-5-19(16-30)31-22-12-13-28-15-21(22)26(29-31)18-8-10-20(11-9-18)35-24-7-3-6-23-27(24)34-17-33-23/h2-3,6-13,15,19H,1,4-5,14,16-17H2/t19-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465450
PNG
((R)-1-(3-(3-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES CCC(=O)N1CCC[C@H](C1)n1nc(-c2ccc(Oc3cccc(OC)c3F)cc2)c2cncc(OC)c12
Show InChI InChI=1S/C28H29FN4O4/c1-4-25(34)32-14-6-7-19(17-32)33-28-21(15-30-16-24(28)36-3)27(31-33)18-10-12-20(13-11-18)37-23-9-5-8-22(35-2)26(23)29/h5,8-13,15-16,19H,4,6-7,14,17H2,1-3H3/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444742
PNG
((R)-1-(3-(3-(4-(4-methylpiperazin-1- yl)phenyl)-1H...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1nn(C2CCN(C2)C(=O)C=C)c2ccncc12
Show InChI InChI=1S/C24H28N6O/c1-3-23(31)29-11-9-20(17-29)30-22-8-10-25-16-21(22)24(26-30)18-4-6-19(7-5-18)28-14-12-27(2)13-15-28/h3-8,10,16,20H,1,9,11-15,17H2,2H3
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444738
PNG
((R)-1-(3-(3-(3'-methyl-[1,1'-biphenyl]- 4-yl)-2H-p...)
Show SMILES Cc1cccc(c1)-c1ccc(cc1)-c1n(nc2ccncc12)[C@@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C26H24N4O/c1-3-25(31)29-14-12-22(17-29)30-26(23-16-27-13-11-24(23)28-30)20-9-7-19(8-10-20)21-6-4-5-18(2)15-21/h3-11,13,15-16,22H,1,12,14,17H2,2H3/t22-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444655
PNG
((R)-1-(3-(3-(4-(2-chloro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C#CC)c3ccncc23)c1Cl
Show InChI InChI=1S/C28H25ClN4O3/c1-3-6-26(34)32-16-5-7-20(18-32)33-23-14-15-30-17-22(23)28(31-33)19-10-12-21(13-11-19)36-25-9-4-8-24(35-2)27(25)29/h4,8-15,17,20H,5,7,16,18H2,1-2H3/t20-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444739
PNG
((R)-1-(3-(3-(4-(4-methylpiperazin-1- yl)phenyl)-1H...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1nn(C2CCCN(C2)C(=O)C=C)c2ccncc12
Show InChI InChI=1S/C25H30N6O/c1-3-24(32)30-12-4-5-21(18-30)31-23-10-11-26-17-22(23)25(27-31)19-6-8-20(9-7-19)29-15-13-28(2)14-16-29/h3,6-11,17,21H,1,4-5,12-16,18H2,2H3
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444741
PNG
((R)-1-(3-(3-(3-fluoro-4-(4- methylpiperazin-1-yl)p...)
Show SMILES CN1CCN(CC1)c1ccc(cc1F)-c1nn(C2CCCN(C2)C(=O)C=C)c2ccncc12
Show InChI InChI=1S/C25H29FN6O/c1-3-24(33)31-10-4-5-19(17-31)32-22-8-9-27-16-20(22)25(28-32)18-6-7-23(21(26)15-18)30-13-11-29(2)12-14-30/h3,6-9,15-16,19H,1,4-5,10-14,17H2,2H3
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444645
PNG
(1-(4-(3-(4-phenoxyphenyl)-1H- pyrazolo[4,3-c]pyrid...)
Show SMILES C=CC(=O)N1CCC(CC1)n1nc(-c2ccc(Oc3ccccc3)cc2)c2cnccc12
Show InChI InChI=1S/C26H24N4O2/c1-2-25(31)29-16-13-20(14-17-29)30-24-12-15-27-18-23(24)26(28-30)19-8-10-22(11-9-19)32-21-6-4-3-5-7-21/h2-12,15,18,20H,1,13-14,16-17H2
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444745
PNG
((R)-1-(3-(3-(4-(4- (methylsulfonyl)piperazin-1-yl)...)
Show SMILES CS(=O)(=O)N1CCN(CC1)c1ccc(cc1)-c1nn(C2CCCN(C2)C(=O)C=C)c2ccncc12
Show InChI InChI=1S/C25H30N6O3S/c1-3-24(32)29-12-4-5-21(18-29)31-23-10-11-26-17-22(23)25(27-31)19-6-8-20(9-7-19)28-13-15-30(16-14-28)35(2,33)34/h3,6-11,17,21H,1,4-5,12-16,18H2,2H3
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50457316
PNG
(CHEMBL4215275 | US10662187, Compound 89 | US107935...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3c(OC)cncc23)c1F
Show InChI InChI=1S/C28H27FN4O4/c1-4-25(34)32-14-6-7-19(17-32)33-28-21(15-30-16-24(28)36-3)27(31-33)18-10-12-20(13-11-18)37-23-9-5-8-22(35-2)26(23)29/h4-5,8-13,15-16,19H,1,6-7,14,17H2,2-3H3/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444736
PNG
(US10662187, Compound 106 | US10793566, Compound 10...)
Show SMILES Cc1cccc(c1)-c1ccc(cc1)-c1nn([C@@H]2CCCN(C2)C(=O)C=C)c2ccncc12
Show InChI InChI=1S/C27H26N4O/c1-3-26(32)30-15-5-8-23(18-30)31-25-13-14-28-17-24(25)27(29-31)21-11-9-20(10-12-21)22-7-4-6-19(2)16-22/h3-4,6-7,9-14,16-17,23H,1,5,8,15,18H2,2H3/t23-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444733
PNG
(US10662187, Compound 103 | US10793566, Compound 10...)
Show SMILES COc1cccc(CNC(=O)c2ccc(cc2)-c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ccncc23)c1
Show InChI InChI=1S/C28H27N5O3/c1-3-26(34)32-14-12-22(18-32)33-25-11-13-29-17-24(25)27(31-33)20-7-9-21(10-8-20)28(35)30-16-19-5-4-6-23(15-19)36-2/h3-11,13,15,17,22H,1,12,14,16,18H2,2H3,(H,30,35)/t22-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444660
PNG
(1-(6-(3-(4-(2-chloro-3- methoxyphenoxy)phenyl)-1H-...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn(C3CC4(C3)CN(C4)C(=O)C=C)c3ccncc23)c1Cl
Show InChI InChI=1S/C28H25ClN4O3/c1-3-25(34)32-16-28(17-32)13-19(14-28)33-22-11-12-30-15-21(22)27(31-33)18-7-9-20(10-8-18)36-24-6-4-5-23(35-2)26(24)29/h3-12,15,19H,1,13-14,16-17H2,2H3
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n/an/a 550n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM50457316
PNG
(CHEMBL4215275 | US10662187, Compound 89 | US107935...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3c(OC)cncc23)c1F
Show InChI InChI=1S/C28H27FN4O4/c1-4-25(34)32-14-6-7-19(17-32)33-28-21(15-30-16-24(28)36-3)27(31-33)18-10-12-20(13-11-18)37-23-9-5-8-22(35-2)26(23)29/h4-5,8-13,15-16,19H,1,6-7,14,17H2,2-3H3/t19-/m1/s1
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n/an/a 5.50E+3n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444744
PNG
((R)-1-(3-(3-((4-(4-methylpiperazin-1- yl)phenyl)am...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nn(C3CCCN(C3)C(=O)C=C)c3ccncc23)cc1
Show InChI InChI=1S/C25H31N7O/c1-3-24(33)31-12-4-5-21(18-31)32-23-10-11-26-17-22(23)25(28-32)27-19-6-8-20(9-7-19)30-15-13-29(2)14-16-30/h3,6-11,17,21H,1,4-5,12-16,18H2,2H3,(H,27,28)
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n/an/a 5.50E+3n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM50457318
PNG
(CHEMBL4218219 | US10662187, Compound 45 | US107935...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCN(C3)C(=O)C=C)c3CCN(Cc23)C(C)=O)c1F
Show InChI InChI=1S/C28H29FN4O4/c1-4-26(35)32-14-12-20(16-32)33-23-13-15-31(18(2)34)17-22(23)28(30-33)19-8-10-21(11-9-19)37-25-7-5-6-24(36-3)27(25)29/h4-11,20H,1,12-17H2,2-3H3/t20-/m1/s1
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n/an/a 5.50E+3n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50457316
PNG
(CHEMBL4215275 | US10662187, Compound 89 | US107935...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3c(OC)cncc23)c1F
Show InChI InChI=1S/C28H27FN4O4/c1-4-25(34)32-14-6-7-19(17-32)33-28-21(15-30-16-24(28)36-3)27(31-33)18-10-12-20(13-11-18)37-23-9-5-8-22(35-2)26(23)29/h4-5,8-13,15-16,19H,1,6-7,14,17H2,2-3H3/t19-/m1/s1
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n/an/a 5.50E+3n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM465362
PNG
(US10793566, Compound 1)
Show SMILES C=CC(=O)N1CC[C@H](C1)n1nc(-c2ccc(Oc3ccccc3)cc2)c2cnccc12
Show InChI InChI=1S/C25H22N4O2/c1-2-24(30)28-15-13-19(17-28)29-23-12-14-26-16-22(23)25(27-29)18-8-10-21(11-9-18)31-20-6-4-3-5-7-20/h2-12,14,16,19H,1,13,15,17H2/t19-/m1/s1
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n/an/a 5.50E+3n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444754
PNG
(4-(3-([1,1'-biphenyl]-4-yl)-1H- pyrazolo[4,3-c] py...)
Show SMILES OC(=O)C1CCC(CC1)n1nc(-c2ccc(cc2)-c2ccccc2)c2cnccc12
Show InChI InChI=1S/C25H23N3O2/c29-25(30)20-10-12-21(13-11-20)28-23-14-15-26-16-22(23)24(27-28)19-8-6-18(7-9-19)17-4-2-1-3-5-17/h1-9,14-16,20-21H,10-13H2,(H,29,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444753
PNG
(4-(3-(4-benzamidophenyl)-1H- pyrazolo[4,3-c] pyrid...)
Show SMILES OC(=O)C1CCC(CC1)n1nc(-c2ccc(NC(=O)c3ccccc3)cc2)c2cnccc12
Show InChI InChI=1S/C26H24N4O3/c31-25(18-4-2-1-3-5-18)28-20-10-6-17(7-11-20)24-22-16-27-15-14-23(22)30(29-24)21-12-8-19(9-13-21)26(32)33/h1-7,10-11,14-16,19,21H,8-9,12-13H2,(H,28,31)(H,32,33)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM465362
PNG
(US10793566, Compound 1)
Show SMILES C=CC(=O)N1CC[C@H](C1)n1nc(-c2ccc(Oc3ccccc3)cc2)c2cnccc12
Show InChI InChI=1S/C25H22N4O2/c1-2-24(30)28-15-13-19(17-28)29-23-12-14-26-16-22(23)25(27-29)18-8-10-21(11-9-18)31-20-6-4-3-5-7-20/h2-12,14,16,19H,1,13,15,17H2/t19-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM444676
PNG
((R)-1-(3-(5-acryloyl-3-(4-(2-fluoro-3- methoxyphen...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCN(C3)C(=O)C=C)c3CCN(Cc23)C(=O)C=C)c1F
Show InChI InChI=1S/C29H29FN4O4/c1-4-26(35)32-15-13-20(17-32)34-23-14-16-33(27(36)5-2)18-22(23)29(31-34)19-9-11-21(12-10-19)38-25-8-6-7-24(37-3)28(25)30/h4-12,20H,1-2,13-18H2,3H3/t20-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10793566 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%