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Patent code US10793591

Compile Data Set for Download or QSAR
Found 16 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RNA-directed RNA polymerase (NS5B)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM466313
PNG
(US10793591, Compound 9)
Show SMILES C[C@@]1(O)[C@H](O)[C@@](F)(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1cnc2c1nc(N)[nH]c2=O
MMDB

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n/an/a<1.00E+3n/an/an/an/an/an/a



Janssen BioPharma, Inc.

US Patent


Assay Description
The enzyme activity of NS5B570-Con1 (Delta-21) was measured as an incorporation of tritiated NMP into acid-insoluble RNA products. The complementary ...


US Patent US10793591 (2020)

More data for this
Ligand-Target Pair
RNA-directed RNA polymerase (NS5B)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM466322
PNG
(US10793591, Compound 63)
Show SMILES C[C@@]1(N=[N+]=N)[C@H](O)[C@@](F)(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(N)nc1=O
Show InChI InChI=1S/C10H16FN6O13P3/c1-9(15-16-13)6(18)10(11,28-7(9)17-3-2-5(12)14-8(17)19)4-27-32(23,24)30-33(25,26)29-31(20,21)22/h2-3,6-7,13,18H,4H2,1H3,(H5-,12,14,19,20,21,22,23,24,25,26)/p+1/t6-,7+,9+,10+/m0/s1
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n/an/a<1.00E+3n/an/an/an/an/an/a



Janssen BioPharma, Inc.

US Patent


Assay Description
The enzyme activity of NS5B570-Con1 (Delta-21) was measured as an incorporation of tritiated NMP into acid-insoluble RNA products. The complementary ...


US Patent US10793591 (2020)

More data for this
Ligand-Target Pair
RNA-directed RNA polymerase (NS5B)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM50274118
PNG
(CHEMBL4127030 | US10793591, Compound 7a)
Show SMILES C[C@@]1(O)[C@H](O)[C@@](F)(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C10H16FN2O15P3/c1-9(17)6(15)10(11,26-7(9)13-3-2-5(14)12-8(13)16)4-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-3,6-7,15,17H,4H2,1H3,(H,21,22)(H,23,24)(H,12,14,16)(H2,18,19,20)/t6-,7+,9+,10+/m0/s1
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Janssen BioPharma, Inc.

US Patent


Assay Description
The enzyme activity of NS5B570-Con1 (Delta-21) was measured as an incorporation of tritiated NMP into acid-insoluble RNA products. The complementary ...


US Patent US10793591 (2020)

More data for this
Ligand-Target Pair
RNA-directed RNA polymerase (NS5B)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM466321
PNG
(US10793591, Compound 50)
Show SMILES C[C@@]1(O)[C@H](O)[C@@](F)(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(N)nc1=O
Show InChI InChI=1S/C10H17FN3O14P3/c1-9(17)6(15)10(11,26-7(9)14-3-2-5(12)13-8(14)16)4-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-3,6-7,15,17H,4H2,1H3,(H,21,22)(H,23,24)(H2,12,13,16)(H2,18,19,20)/t6-,7+,9+,10+/m0/s1
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Janssen BioPharma, Inc.

US Patent


Assay Description
The enzyme activity of NS5B570-Con1 (Delta-21) was measured as an incorporation of tritiated NMP into acid-insoluble RNA products. The complementary ...


US Patent US10793591 (2020)

More data for this
Ligand-Target Pair
RNA-directed RNA polymerase (NS5B)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM50274124
PNG
(CHEMBL4125966 | US10793591, Compound 12)
Show SMILES O[C@@H]1[C@@](F)(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@@H](n2ccc(=O)[nH]c2=O)[C@@]1(O)C#C
Show InChI InChI=1S/C11H14FN2O15P3/c1-2-10(18)7(16)11(12,27-8(10)14-4-3-6(15)13-9(14)17)5-26-31(22,23)29-32(24,25)28-30(19,20)21/h1,3-4,7-8,16,18H,5H2,(H,22,23)(H,24,25)(H,13,15,17)(H2,19,20,21)/t7-,8+,10+,11+/m0/s1
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Janssen BioPharma, Inc.

US Patent


Assay Description
The enzyme activity of NS5B570-Con1 (Delta-21) was measured as an incorporation of tritiated NMP into acid-insoluble RNA products. The complementary ...


US Patent US10793591 (2020)

More data for this
Ligand-Target Pair
RNA-directed RNA polymerase (NS5B)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM466319
PNG
(US10793591, Compound 44)
Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@](F)(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@]1(F)C#C
MMDB

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n/an/a<1.00E+3n/an/an/an/an/an/a



Janssen BioPharma, Inc.

US Patent


Assay Description
The enzyme activity of NS5B570-Con1 (Delta-21) was measured as an incorporation of tritiated NMP into acid-insoluble RNA products. The complementary ...


US Patent US10793591 (2020)

More data for this
Ligand-Target Pair
RNA-directed RNA polymerase (NS5B)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM466325
PNG
(US10793591, Compound 76)
Show SMILES O[C@@H]1[C@@](F)(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@@H](n2ccc(=O)[nH]c2=O)[C@@]1(F)CF
MMDB

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n/an/a<1.00E+3n/an/an/an/an/an/a



Janssen BioPharma, Inc.

US Patent


Assay Description
The enzyme activity of NS5B570-Con1 (Delta-21) was measured as an incorporation of tritiated NMP into acid-insoluble RNA products. The complementary ...


US Patent US10793591 (2020)

More data for this
Ligand-Target Pair
RNA-directed RNA polymerase (NS5B)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM50524192
PNG
(CHEMBL4440367 | US10793591, Compound 26)
Show SMILES C[C@@]1(F)[C@H](O)[C@@](F)(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=O
MMDB

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n/an/a<1.00E+3n/an/an/an/an/an/a



Janssen BioPharma, Inc.

US Patent


Assay Description
The enzyme activity of NS5B570-Con1 (Delta-21) was measured as an incorporation of tritiated NMP into acid-insoluble RNA products. The complementary ...


US Patent US10793591 (2020)

More data for this
Ligand-Target Pair
RNA-directed RNA polymerase (NS5B)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM466317
PNG
(US10793591, Compound 28)
Show SMILES C[C@@]1(F)[C@H](O)[C@@](F)(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N1C=NC2C1N=C(N)NC2=O
Show InChI InChI=1S/C11H18F2N5O13P3/c1-10(12)7(20)11(13,2-28-33(24,25)31-34(26,27)30-32(21,22)23)29-8(10)18-3-15-4-5(18)16-9(14)17-6(4)19/h3-5,7-8,20H,2H2,1H3,(H,24,25)(H,26,27)(H2,21,22,23)(H3,14,16,17,19)/t4?,5?,7-,8+,10+,11+/m0/s1
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Janssen BioPharma, Inc.

US Patent


Assay Description
The enzyme activity of NS5B570-Con1 (Delta-21) was measured as an incorporation of tritiated NMP into acid-insoluble RNA products. The complementary ...


US Patent US10793591 (2020)

More data for this
Ligand-Target Pair
RNA-directed RNA polymerase (NS5B)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM50524197
PNG
(CHEMBL4555315 | US10793591, Compound 46)
Show SMILES C[C@@]1(Cl)[C@H](O)[C@@](F)(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=O
MMDB

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Janssen BioPharma, Inc.

US Patent


Assay Description
The enzyme activity of NS5B570-Con1 (Delta-21) was measured as an incorporation of tritiated NMP into acid-insoluble RNA products. The complementary ...


US Patent US10793591 (2020)

More data for this
Ligand-Target Pair
RNA-directed RNA polymerase (NS5B)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM466323
PNG
(US10793591, Compound 64)
Show SMILES C[C@@]1(N)[C@H](O)[C@@](F)(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(N)nc1=O
Show InChI InChI=1S/C10H18FN4O13P3/c1-9(13)6(16)10(11,26-7(9)15-3-2-5(12)14-8(15)17)4-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-3,6-7,16H,4,13H2,1H3,(H,21,22)(H,23,24)(H2,12,14,17)(H2,18,19,20)/t6-,7+,9+,10+/m0/s1
MMDB

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Janssen BioPharma, Inc.

US Patent


Assay Description
The enzyme activity of NS5B570-Con1 (Delta-21) was measured as an incorporation of tritiated NMP into acid-insoluble RNA products. The complementary ...


US Patent US10793591 (2020)

More data for this
Ligand-Target Pair
RNA-directed RNA polymerase (NS5B)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM50274118
PNG
(CHEMBL4127030 | US10793591, Compound 7a)
Show SMILES C[C@@]1(O)[C@H](O)[C@@](F)(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C10H16FN2O15P3/c1-9(17)6(15)10(11,26-7(9)13-3-2-5(14)12-8(13)16)4-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-3,6-7,15,17H,4H2,1H3,(H,21,22)(H,23,24)(H,12,14,16)(H2,18,19,20)/t6-,7+,9+,10+/m0/s1
MMDB

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Janssen BioPharma, Inc.

US Patent


Assay Description
The enzyme activity of NS5B570-Con1 (Delta-21) was measured as an incorporation of tritiated NMP into acid-insoluble RNA products. The complementary ...


US Patent US10793591 (2020)

More data for this
Ligand-Target Pair
RNA-directed RNA polymerase (NS5B)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM466315
PNG
(US10793591, Compound 15)
Show SMILES NC1=NC2C(N=CN2[C@@H]2O[C@](F)(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@]2(O)C#C)C(=O)N1
Show InChI InChI=1S/C12H17FN5O14P3/c1-2-11(21)8(20)12(13,3-29-34(25,26)32-35(27,28)31-33(22,23)24)30-9(11)18-4-15-5-6(18)16-10(14)17-7(5)19/h1,4-6,8-9,20-21H,3H2,(H,25,26)(H,27,28)(H2,22,23,24)(H3,14,16,17,19)/t5?,6?,8-,9+,11+,12+/m0/s1
MMDB

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Janssen BioPharma, Inc.

US Patent


Assay Description
The enzyme activity of NS5B570-Con1 (Delta-21) was measured as an incorporation of tritiated NMP into acid-insoluble RNA products. The complementary ...


US Patent US10793591 (2020)

More data for this
Ligand-Target Pair
RNA-directed RNA polymerase (NS5B)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM466324
PNG
(US10793591, Compound 69)
Show SMILES Nc1ccn([C@@H]2O[C@](F)(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@]2(F)C#C)c(=O)n1
Show InChI InChI=1S/C11H14F2N3O13P3/c1-2-10(12)7(17)11(13,27-8(10)16-4-3-6(14)15-9(16)18)5-26-31(22,23)29-32(24,25)28-30(19,20)21/h1,3-4,7-8,17H,5H2,(H,22,23)(H,24,25)(H2,14,15,18)(H2,19,20,21)/t7-,8+,10+,11+/m0/s1
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Janssen BioPharma, Inc.

US Patent


Assay Description
The enzyme activity of NS5B570-Con1 (Delta-21) was measured as an incorporation of tritiated NMP into acid-insoluble RNA products. The complementary ...


US Patent US10793591 (2020)

More data for this
Ligand-Target Pair
RNA-directed RNA polymerase (NS5B)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM466318
PNG
(US10793591, Compound 38)
Show SMILES C[C@@]1(F)[C@H](O)[C@@](F)(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(N)nc1=O
Show InChI InChI=1S/C10H16F2N3O13P3/c1-9(11)6(16)10(12,26-7(9)15-3-2-5(13)14-8(15)17)4-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-3,6-7,16H,4H2,1H3,(H,21,22)(H,23,24)(H2,13,14,17)(H2,18,19,20)/t6-,7+,9+,10+/m0/s1
MMDB

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Janssen BioPharma, Inc.

US Patent


Assay Description
The enzyme activity of NS5B570-Con1 (Delta-21) was measured as an incorporation of tritiated NMP into acid-insoluble RNA products. The complementary ...


US Patent US10793591 (2020)

More data for this
Ligand-Target Pair
RNA-directed RNA polymerase (NS5B)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM466312
PNG
(US10793591, Compound 7b)
Show SMILES C[C@@]1(O)[C@H](O)[C@](F)(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=O
MMDB

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n/an/a 5.50E+3n/an/an/an/an/an/a



Janssen BioPharma, Inc.

US Patent


Assay Description
The enzyme activity of NS5B570-Con1 (Delta-21) was measured as an incorporation of tritiated NMP into acid-insoluble RNA products. The complementary ...


US Patent US10793591 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%