BindingDB logo
myBDB logout

Patent code US10799507

Compile Data Set for Download or QSAR

Found 607 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466345
PNG
((8S)-N-[(1S,2S)-2- cyclohexyl-2- hydroxy-1- methyl...)
Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@@H](O)C1CCCCC1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 6.20n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466346
PNG
((8S)-N-[(2S)-2- cyclohexyl-2- hydroxy-ethyl]-5- (7...)
Show SMILES O[C@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCCC1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 4n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466347
PNG
((8S)óN-[(1S,2S)-2-Cyclopentyl-2-Hydroxy-1-Methyl-E...)
Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@@H](O)C1CCCC1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.10n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM466348
PNG
((8S)-N-[(1S,2S)-2- (4-fluorophenyl)- 2-hydroxy-1- ...)
Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@@H](O)c1ccc(F)cc1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 7.40n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466354
PNG
((8S)-N-[(2R)-2-(5- fluoro-2-pyridyl)- 2-hydroxy-et...)
Show SMILES O[C@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(F)cn1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 13.9n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466356
PNG
((8S)-N-[(1S)-1-(4- cyano-3-fluoro- phenyl)ethyl]-5...)
Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(C#N)c(F)c1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.20n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM466357
PNG
((8S)-N-[(2R)-2- cyclohexyl-2- hydroxy-ethyl]-5- (7...)
Show SMILES O[C@@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCCC1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.900n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM466357
PNG
((8S)-N-[(2R)-2- cyclohexyl-2- hydroxy-ethyl]-5- (7...)
Show SMILES O[C@@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCCC1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.70n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466357
PNG
((8S)-N-[(2R)-2- cyclohexyl-2- hydroxy-ethyl]-5- (7...)
Show SMILES O[C@@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCCC1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 7.40n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466358
PNG
((8S)-N-[(4-cyano- 3-fluoro- phenyl)methyl]-5- (7H-...)
Show SMILES Fc1cc(CNC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)ccc1C#N
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.60n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM466359
PNG
((8S)-N-[(1R)-1-(4- fluorophenyl)-2- hydroxy-ethyl]...)
Show SMILES OC[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(F)cc1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466359
PNG
((8S)-N-[(1R)-1-(4- fluorophenyl)-2- hydroxy-ethyl]...)
Show SMILES OC[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(F)cc1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM466362
PNG
((8S)-N-[(1S)-1-(4- cyano-2-fluoro- phenyl)ethyl]-5...)
Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(cc1F)C#N
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 17.6n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM466363
PNG
(N-[(1S)-1-(4- cyanophenyl) ethyl]-5-(7H- pyrrolo[2...)
Show SMILES C[C@H](NC(=O)C1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(cc1)C#N
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 7.70n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM466368
PNG
(N-[(4- cyanophenyl) methyl]-5-(7H- pyrrolo[2,3- d]...)
Show SMILES O=C(NCc1ccc(cc1)C#N)C1CCN(CC11CC1)c1ncnc2[nH]ccc12
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.40n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466368
PNG
(N-[(4- cyanophenyl) methyl]-5-(7H- pyrrolo[2,3- d]...)
Show SMILES O=C(NCc1ccc(cc1)C#N)C1CCN(CC11CC1)c1ncnc2[nH]ccc12
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 196n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM466370
PNG
((8S)-N-[(1R)-1-(4- cyanophenyl)-2- hydroxy-1- meth...)
Show SMILES C[C@@](CO)(NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(cc1)C#N
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 9.80n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM466371
PNG
((8S)-N-[(2R)-2-(4- cyanophenyl)-2- hydroxy-ethyl]-...)
Show SMILES O[C@@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(cc1)C#N
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 6.5n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466383
PNG
((8S)óN-[(1S,2R)-2-(5-Fluoro-2-Pyridyl)-2-Hydroxy-1...)
Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@@H](O)c1ccc(F)cn1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 33.5n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM466384
PNG
((3,3- difluorocyclobutyl) methyl (2R)-3- hydroxy-2...)
Show SMILES OC[C@@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C(=O)OCC1CC(F)(F)C1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.70n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466388
PNG
((8S)-N-[(2S)-2-(5- fluoro-2-pyridyl)- 2-hydroxy-et...)
Show SMILES O[C@@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(F)cn1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 48.1n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM466391
PNG
((8S)-N-[(1- hydroxycyclopentyl) methyl]-5-(7H- pyr...)
Show SMILES OC1(CNC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)CCCC1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 26.1n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM466392
PNG
((8S)-N-[(1S,2R)-2- (4-fluorophenyl)- 2-hydroxy-1- ...)
Show SMILES OC[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@H](O)c1ccc(F)cc1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 22.7n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM466395
PNG
(N-[(4- fluorophenyl) methyl]-5-(7H- pyrrolo[2,3- d...)
Show SMILES Fc1ccc(CNC(=O)C2CCN(CC22CC2)c2ncnc3[nH]ccc23)cc1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.60n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM466396
PNG
((8S)-N-[(1R)-1-(4- cyano-3-methyl- phenyl)-2- hydr...)
Show SMILES Cc1cc(ccc1C#N)[C@H](CO)NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 33n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM466398
PNG
(N-[(3,3- difluorocyclobutyl) methyl]-5-(7H- pyrrol...)
Show SMILES FC1(F)CC(CNC(=O)C2CCN(CC22CC2)c2ncnc3[nH]ccc23)C1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.90n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM466398
PNG
(N-[(3,3- difluorocyclobutyl) methyl]-5-(7H- pyrrol...)
Show SMILES FC1(F)CC(CNC(=O)C2CCN(CC22CC2)c2ncnc3[nH]ccc23)C1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 18.1n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM466399
PNG
((8S)-N-[(1R)-1-(5- cyano-2-pyridyl)- 2-hydroxy-1- ...)
Show SMILES C[C@@](CO)(NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 21.3n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466400
PNG
(N-[[1- (hydroxymethyl) cyclopentyl]methyl]- 5-(7H-...)
Show SMILES OCC1(CNC(=O)C2CCN(CC22CC2)c2ncnc3[nH]ccc23)CCCC1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 142n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM466402
PNG
(N-[1-(4- fluorophenyl)ethyl]- 5-(7H- pyrrolo[2,3- ...)
Show SMILES CC(NC(=O)C1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(F)cc1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 4.30n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM466403
PNG
((8S)-N-[(3,3- difluorocyclobutyl) methyl]-5-(7H- p...)
Show SMILES FC1(F)CC(CNC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)C1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 15.7n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466404
PNG
(N-[(2S)-2- hydroxy-2- phenyl-ethyl]-5- (7H-pyrrolo...)
Show SMILES O[C@H](CNC(=O)C1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccccc1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 147n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM466405
PNG
((8S)-N-[(2S)-2- hydroxy-2- (p-tolyl)ethyl]-5- (7H-...)
Show SMILES Cc1ccc(cc1)[C@H](O)CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 4.5n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM466406
PNG
(N-[(1S)-1-(4- methoxyphenyl) ethyl]-5-(7H- pyrrolo...)
Show SMILES COc1ccc(cc1)[C@H](C)NC(=O)C1CCN(CC11CC1)c1ncnc2[nH]ccc12
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 4.80n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466406
PNG
(N-[(1S)-1-(4- methoxyphenyl) ethyl]-5-(7H- pyrrolo...)
Show SMILES COc1ccc(cc1)[C@H](C)NC(=O)C1CCN(CC11CC1)c1ncnc2[nH]ccc12
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 8.30n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM466409
PNG
(N-[(1R)-2- hydroxy-1- phenyl-ethyl]-5- (7H-pyrrolo...)
Show SMILES OC[C@H](NC(=O)C1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccccc1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.10n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466409
PNG
(N-[(1R)-2- hydroxy-1- phenyl-ethyl]-5- (7H-pyrrolo...)
Show SMILES OC[C@H](NC(=O)C1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccccc1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 12n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466373
PNG
((8S)-N-[(4-cyano- 2-fluoro- phenyl)methyl]-5- (7H-...)
Show SMILES Fc1cc(ccc1CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C#N
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 63.7n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM466376
PNG
((8S)-N-[(1R)-1- (2,4- difluorophenyl)-2- hydroxy-e...)
Show SMILES OC[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(F)cc1F
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.90n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466378
PNG
((8S)-N-[(2S)-2-(5- cyano-2-pyridyl)- 2-hydroxy-eth...)
Show SMILES O[C@@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 70.5n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466379
PNG
((8S)-N-[(1R)-1-(4- cyano-2-methyl- phenyl)-2- hydr...)
Show SMILES Cc1cc(ccc1[C@H](CO)NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C#N
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 102n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466485
PNG
((8S)-N-[(1S,2S)-2- (3-fluorophenyl)- 2-hydroxy-1- ...)
Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@@H](O)c1cccc(F)c1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 21n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM466495
PNG
(US10799507, Example 161 | [1-(Hydroxymethyl)Cycloh...)
Show SMILES OCC1(COC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)CCCCC1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.5n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466495
PNG
(US10799507, Example 161 | [1-(Hydroxymethyl)Cycloh...)
Show SMILES OCC1(COC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)CCCCC1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.70n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM466496
PNG
(US10799507, Example 162 | [3-(Hydroxymethyl)-1,1-D...)
Show SMILES OCC1(COC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)CS(=O)(=O)C1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.5n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM466498
PNG
(US10799507, Example 164 | [1-(Cyanomethyl)Cyclopro...)
Show SMILES O=C(OCC1(CC#N)CC1)C1CCN(CC11CC1)c1ncnc2[nH]ccc12
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 19n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466412
PNG
((8S)-N-[(1S,2S)-2- hydroxy-1- methyl-2-(p- tolyl)e...)
Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@@H](O)c1ccc(C)cc1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 171n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM466418
PNG
(Benzyl (2R)-3-Hydroxy-2-[[(8S)-5-(7H-Pyrrolo[2,3-d...)
Show SMILES OC[C@@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C(=O)OCc1ccccc1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 6.70n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM466418
PNG
(Benzyl (2R)-3-Hydroxy-2-[[(8S)-5-(7H-Pyrrolo[2,3-d...)
Show SMILES OC[C@@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C(=O)OCc1ccccc1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 24.3n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM466420
PNG
(N- (cyclopentylmethyl)- 5-(7H- pyrrolo[2,3- d]pyri...)
Show SMILES O=C(NCC1CCCC1)C1CCN(CC11CC1)c1ncnc2[nH]ccc12
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 6.80n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 607 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%