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Patent code US10800739

Compile Data Set for Download or QSAR
Found 37 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM50110812
PNG
(CHEMBL3606011 | US10800739, Compound (12))
Show SMILES NC(=O)c1cccc2CN(C3CCN(Cc4ccco4)CC3)C(=O)c12
Show InChI InChI=1S/C19H21N3O3/c20-18(23)16-5-1-3-13-11-22(19(24)17(13)16)14-6-8-21(9-7-14)12-15-4-2-10-25-15/h1-5,10,14H,6-9,11-12H2,(H2,20,23)
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US Patent
n/an/an/a 1.70E+3n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM50110832
PNG
(CHEMBL3605982 | US10800739, Compound (16))
Show SMILES NC(=O)c1cccc2CN(CCN3CCCc4ccccc34)C(=O)c12
Show InChI InChI=1S/C20H21N3O2/c21-19(24)16-8-3-6-15-13-23(20(25)18(15)16)12-11-22-10-4-7-14-5-1-2-9-17(14)22/h1-3,5-6,8-9H,4,7,10-13H2,(H2,21,24)
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n/an/an/a<30n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM466544
PNG
(US10800739, Compound (23))
Show SMILES NC(=O)c1cc(F)cc2CN(CCCN3CCOCC3)C(=O)c12
Show InChI InChI=1S/C16H20FN3O3/c17-12-8-11-10-20(3-1-2-19-4-6-23-7-5-19)16(22)14(11)13(9-12)15(18)21/h8-9H,1-7,10H2,(H2,18,21)
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n/an/an/a<30n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM50110840
PNG
(CHEMBL3605994 | US10800739, Compound (24))
Show SMILES NC(=O)c1cccc2CN(C3CCN(CC4CC4)CC3)C(=O)c12
Show InChI InChI=1S/C18H23N3O2/c19-17(22)15-3-1-2-13-11-21(18(23)16(13)15)14-6-8-20(9-7-14)10-12-4-5-12/h1-3,12,14H,4-11H2,(H2,19,22)
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n/an/an/a 4.40E+4n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM466534
PNG
(US10800739, Compound (11))
Show SMILES NC(=O)c1cccc2CN(C3CCN(CC3)C3CCCCC3)C(=O)c12
Show InChI InChI=1S/C20H27N3O2/c21-19(24)17-8-4-5-14-13-23(20(25)18(14)17)16-9-11-22(12-10-16)15-6-2-1-3-7-15/h4-5,8,15-16H,1-3,6-7,9-13H2,(H2,21,24)
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n/an/an/a<10n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM50113458
PNG
(CHEMBL3605975 | US10800739, Compound (14))
Show SMILES NC(=O)c1cccc2CN(CCN3CCOCC3)C(=O)c12
Show InChI InChI=1S/C15H19N3O3/c16-14(19)12-3-1-2-11-10-18(15(20)13(11)12)5-4-17-6-8-21-9-7-17/h1-3H,4-10H2,(H2,16,19)
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n/an/an/a 580n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM50110840
PNG
(CHEMBL3605994 | US10800739, Compound (24))
Show SMILES NC(=O)c1cccc2CN(C3CCN(CC4CC4)CC3)C(=O)c12
Show InChI InChI=1S/C18H23N3O2/c19-17(22)15-3-1-2-13-11-21(18(23)16(13)15)14-6-8-20(9-7-14)10-12-4-5-12/h1-3,12,14H,4-11H2,(H2,19,22)
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n/an/an/a<30n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM50110836
PNG
(CHEMBL3606017 | US10800739, Compound (28))
Show SMILES NC(=O)c1cccc2CN(C3CCN(CC3)C3CCOCC3)C(=O)c12
Show InChI InChI=1S/C19H25N3O3/c20-18(23)16-3-1-2-13-12-22(19(24)17(13)16)15-4-8-21(9-5-15)14-6-10-25-11-7-14/h1-3,14-15H,4-12H2,(H2,20,23)
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n/an/an/a<30n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM50110831
PNG
(CHEMBL3605981 | US10800739, Compound (32))
Show SMILES NC(=O)c1cccc2CN(CCCN3CCC(Cc4ccccc4)CC3)C(=O)c12
Show InChI InChI=1S/C24H29N3O2/c25-23(28)21-9-4-8-20-17-27(24(29)22(20)21)13-5-12-26-14-10-19(11-15-26)16-18-6-2-1-3-7-18/h1-4,6-9,19H,5,10-17H2,(H2,25,28)
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n/an/an/a 48n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM50110831
PNG
(CHEMBL3605981 | US10800739, Compound (32))
Show SMILES NC(=O)c1cccc2CN(CCCN3CCC(Cc4ccccc4)CC3)C(=O)c12
Show InChI InChI=1S/C24H29N3O2/c25-23(28)21-9-4-8-20-17-27(24(29)22(20)21)13-5-12-26-14-10-19(11-15-26)16-18-6-2-1-3-7-18/h1-4,6-9,19H,5,10-17H2,(H2,25,28)
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n/an/an/a 660n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM50110829
PNG
(CHEMBL3605976 | US10800739, Compound (15))
Show SMILES NC(=O)c1cccc2CN(CCCN3CCOCC3)C(=O)c12
Show InChI InChI=1S/C16H21N3O3/c17-15(20)13-4-1-3-12-11-19(16(21)14(12)13)6-2-5-18-7-9-22-10-8-18/h1,3-4H,2,5-11H2,(H2,17,20)
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n/an/an/a 40n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM50110832
PNG
(CHEMBL3605982 | US10800739, Compound (16))
Show SMILES NC(=O)c1cccc2CN(CCN3CCCc4ccccc34)C(=O)c12
Show InChI InChI=1S/C20H21N3O2/c21-19(24)16-8-3-6-15-13-23(20(25)18(15)16)12-11-22-10-4-7-14-5-1-2-9-17(14)22/h1-3,5-6,8-9H,4,7,10-13H2,(H2,21,24)
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n/an/an/a 420n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM50110842
PNG
(CHEMBL3606006 | US10800739, Compound (8))
Show SMILES NC(=O)c1cccc2CN(C3CCN(Cc4ccncc4)CC3)C(=O)c12
Show InChI InChI=1S/C20H22N4O2/c21-19(25)17-3-1-2-15-13-24(20(26)18(15)17)16-6-10-23(11-7-16)12-14-4-8-22-9-5-14/h1-5,8-9,16H,6-7,10-13H2,(H2,21,25)
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n/an/an/a 50n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM50110826
PNG
(CHEMBL3605972 | US10800739, Compound (2))
Show SMILES NC(=O)c1cccc2CN(CCc3ccccc3)C(=O)c12
Show InChI InChI=1S/C17H16N2O2/c18-16(20)14-8-4-7-13-11-19(17(21)15(13)14)10-9-12-5-2-1-3-6-12/h1-8H,9-11H2,(H2,18,20)
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n/an/an/a<30n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM50110808
PNG
(CHEMBL3606007 | US10800739, Compound (10))
Show SMILES NC(=O)c1cccc2CN(C3CCN(Cc4cccnc4)CC3)C(=O)c12
Show InChI InChI=1S/C20H22N4O2/c21-19(25)17-5-1-4-15-13-24(20(26)18(15)17)16-6-9-23(10-7-16)12-14-3-2-8-22-11-14/h1-5,8,11,16H,6-7,9-10,12-13H2,(H2,21,25)
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n/an/an/a 6.80E+3n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM466534
PNG
(US10800739, Compound (11))
Show SMILES NC(=O)c1cccc2CN(C3CCN(CC3)C3CCCCC3)C(=O)c12
Show InChI InChI=1S/C20H27N3O2/c21-19(24)17-8-4-5-14-13-23(20(25)18(14)17)16-9-11-22(12-10-16)15-6-2-1-3-7-15/h4-5,8,15-16H,1-3,6-7,9-13H2,(H2,21,24)
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n/an/an/a 1.40E+3n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM466541
PNG
(US10800739, Compound (19))
Show SMILES NC(=O)c1cccc2CN(CCCN3CCc4ccccc4C3)C(=O)c12
Show InChI InChI=1S/C21H23N3O2/c22-20(25)18-8-3-7-17-14-24(21(26)19(17)18)11-4-10-23-12-9-15-5-1-2-6-16(15)13-23/h1-3,5-8H,4,9-14H2,(H2,22,25)
PDB

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n/an/an/a 1.39E+3n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM50110833
PNG
(CHEMBL3605983 | US10800739, Compound (3))
Show SMILES NC(=O)c1cccc2CN(CCN3CCc4ccccc4C3)C(=O)c12
Show InChI InChI=1S/C20H21N3O2/c21-19(24)17-7-3-6-16-13-23(20(25)18(16)17)11-10-22-9-8-14-4-1-2-5-15(14)12-22/h1-7H,8-13H2,(H2,21,24)
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n/an/an/a<30n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM50110829
PNG
(CHEMBL3605976 | US10800739, Compound (15))
Show SMILES NC(=O)c1cccc2CN(CCCN3CCOCC3)C(=O)c12
Show InChI InChI=1S/C16H21N3O3/c17-15(20)13-4-1-3-12-11-19(16(21)14(12)13)6-2-5-18-7-9-22-10-8-18/h1,3-4H,2,5-11H2,(H2,17,20)
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n/an/an/a 40n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM50110832
PNG
(CHEMBL3605982 | US10800739, Compound (16))
Show SMILES NC(=O)c1cccc2CN(CCN3CCCc4ccccc34)C(=O)c12
Show InChI InChI=1S/C20H21N3O2/c21-19(24)16-8-3-6-15-13-23(20(25)18(15)16)12-11-22-10-4-7-14-5-1-2-9-17(14)22/h1-3,5-6,8-9H,4,7,10-13H2,(H2,21,24)
PDB

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n/an/an/a 980n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM50110827
PNG
(CHEMBL3605973 | US10800739, Compound (17))
Show SMILES NC(=O)c1cccc2CN(CCCc3ccccc3)C(=O)c12
Show InChI InChI=1S/C18H18N2O2/c19-17(21)15-10-4-9-14-12-20(18(22)16(14)15)11-5-8-13-6-2-1-3-7-13/h1-4,6-7,9-10H,5,8,11-12H2,(H2,19,21)
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n/an/an/a<30n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM50110827
PNG
(CHEMBL3605973 | US10800739, Compound (17))
Show SMILES NC(=O)c1cccc2CN(CCCc3ccccc3)C(=O)c12
Show InChI InChI=1S/C18H18N2O2/c19-17(21)15-10-4-9-14-12-20(18(22)16(14)15)11-5-8-13-6-2-1-3-7-13/h1-4,6-7,9-10H,5,8,11-12H2,(H2,19,21)
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n/an/an/a 290n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM466541
PNG
(US10800739, Compound (19))
Show SMILES NC(=O)c1cccc2CN(CCCN3CCc4ccccc4C3)C(=O)c12
Show InChI InChI=1S/C21H23N3O2/c22-20(25)18-8-3-7-17-14-24(21(26)19(17)18)11-4-10-23-12-9-15-5-1-2-6-16(15)13-23/h1-3,5-8H,4,9-14H2,(H2,22,25)
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n/an/an/a<30n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM466542
PNG
(US10800739, Compound (20))
Show SMILES NC(=O)c1cccc2CN(CCCN3CCCc4ccccc34)C(=O)c12
Show InChI InChI=1S/C21H23N3O2/c22-20(25)17-9-3-7-16-14-24(21(26)19(16)17)13-5-12-23-11-4-8-15-6-1-2-10-18(15)23/h1-3,6-7,9-10H,4-5,8,11-14H2,(H2,22,25)
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n/an/an/a<30n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM466542
PNG
(US10800739, Compound (20))
Show SMILES NC(=O)c1cccc2CN(CCCN3CCCc4ccccc34)C(=O)c12
Show InChI InChI=1S/C21H23N3O2/c22-20(25)17-9-3-7-16-14-24(21(26)19(16)17)13-5-12-23-11-4-8-15-6-1-2-10-18(15)23/h1-3,6-7,9-10H,4-5,8,11-14H2,(H2,22,25)
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n/an/an/a 190n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM50110826
PNG
(CHEMBL3605972 | US10800739, Compound (2))
Show SMILES NC(=O)c1cccc2CN(CCc3ccccc3)C(=O)c12
Show InChI InChI=1S/C17H16N2O2/c18-16(20)14-8-4-7-13-11-19(17(21)15(13)14)10-9-12-5-2-1-3-6-12/h1-8H,9-11H2,(H2,18,20)
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n/an/an/a 180n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM50110829
PNG
(CHEMBL3605976 | US10800739, Compound (15))
Show SMILES NC(=O)c1cccc2CN(CCCN3CCOCC3)C(=O)c12
Show InChI InChI=1S/C16H21N3O3/c17-15(20)13-4-1-3-12-11-19(16(21)14(12)13)6-2-5-18-7-9-22-10-8-18/h1,3-4H,2,5-11H2,(H2,17,20)
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n/an/an/a 5.87E+3n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM50110812
PNG
(CHEMBL3606011 | US10800739, Compound (12))
Show SMILES NC(=O)c1cccc2CN(C3CCN(Cc4ccco4)CC3)C(=O)c12
Show InChI InChI=1S/C19H21N3O3/c20-18(23)16-5-1-3-13-11-22(19(24)17(13)16)14-6-8-21(9-7-14)12-15-4-2-10-25-15/h1-5,10,14H,6-9,11-12H2,(H2,20,23)
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n/an/an/a<30n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM50110811
PNG
(CHEMBL3606010 | US10800739, Compound (13))
Show SMILES NC(=O)c1cccc2CN(C3CCN(Cc4ccsc4)CC3)C(=O)c12
Show InChI InChI=1S/C19H21N3O2S/c20-18(23)16-3-1-2-14-11-22(19(24)17(14)16)15-4-7-21(8-5-15)10-13-6-9-25-12-13/h1-3,6,9,12,15H,4-5,7-8,10-11H2,(H2,20,23)
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n/an/an/a<30n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM50110832
PNG
(CHEMBL3605982 | US10800739, Compound (16))
Show SMILES NC(=O)c1cccc2CN(CCN3CCCc4ccccc34)C(=O)c12
Show InChI InChI=1S/C20H21N3O2/c21-19(24)16-8-3-6-15-13-23(20(25)18(15)16)12-11-22-10-4-7-14-5-1-2-9-17(14)22/h1-3,5-6,8-9H,4,7,10-13H2,(H2,21,24)
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n/an/an/a 60n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM50110810
PNG
(CHEMBL3606009 | US10800739, Compound (9))
Show SMILES NC(=O)c1cccc2CN(C3CCN(Cc4cccs4)CC3)C(=O)c12
Show InChI InChI=1S/C19H21N3O2S/c20-18(23)16-5-1-3-13-11-22(19(24)17(13)16)14-6-8-21(9-7-14)12-15-4-2-10-25-15/h1-5,10,14H,6-9,11-12H2,(H2,20,23)
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n/an/an/a<30n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM50110810
PNG
(CHEMBL3606009 | US10800739, Compound (9))
Show SMILES NC(=O)c1cccc2CN(C3CCN(Cc4cccs4)CC3)C(=O)c12
Show InChI InChI=1S/C19H21N3O2S/c20-18(23)16-5-1-3-13-11-22(19(24)17(13)16)14-6-8-21(9-7-14)12-15-4-2-10-25-15/h1-5,10,14H,6-9,11-12H2,(H2,20,23)
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n/an/an/a 1.44E+3n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM466543
PNG
(US10800739, Compound (22))
Show SMILES NC(=O)c1cccc2CN(CCCN3CCN(CC3)c3ccccc3)C(=O)c12
Show InChI InChI=1S/C22H26N4O2/c23-21(27)19-9-4-6-17-16-26(22(28)20(17)19)11-5-10-24-12-14-25(15-13-24)18-7-2-1-3-8-18/h1-4,6-9H,5,10-16H2,(H2,23,27)
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n/an/an/a<30n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM466548
PNG
(US10800739, Compound (29))
Show SMILES NC(=O)c1cc(F)cc2CN(C3CCN(CC3)C3CCCCC3)C(=O)c12
Show InChI InChI=1S/C20H26FN3O2/c21-14-10-13-12-24(20(26)18(13)17(11-14)19(22)25)16-6-8-23(9-7-16)15-4-2-1-3-5-15/h10-11,15-16H,1-9,12H2,(H2,22,25)
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n/an/an/a<10n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM50110833
PNG
(CHEMBL3605983 | US10800739, Compound (3))
Show SMILES NC(=O)c1cccc2CN(CCN3CCc4ccccc4C3)C(=O)c12
Show InChI InChI=1S/C20H21N3O2/c21-19(24)17-7-3-6-16-13-23(20(25)18(16)17)11-10-22-9-8-14-4-1-2-5-15(14)12-22/h1-7H,8-13H2,(H2,21,24)
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n/an/an/a 5.80E+3n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM50110808
PNG
(CHEMBL3606007 | US10800739, Compound (10))
Show SMILES NC(=O)c1cccc2CN(C3CCN(Cc4cccnc4)CC3)C(=O)c12
Show InChI InChI=1S/C20H22N4O2/c21-19(25)17-5-1-4-15-13-24(20(26)18(15)17)16-6-9-23(10-7-16)12-14-3-2-8-22-11-14/h1-5,8,11,16H,6-7,9-10,12-13H2,(H2,21,25)
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n/an/an/a 70n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM50113458
PNG
(CHEMBL3605975 | US10800739, Compound (14))
Show SMILES NC(=O)c1cccc2CN(CCN3CCOCC3)C(=O)c12
Show InChI InChI=1S/C15H19N3O3/c16-14(19)12-3-1-2-11-10-18(15(20)13(11)12)5-4-17-6-8-21-9-7-17/h1-3H,4-10H2,(H2,16,19)
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n/an/an/a<30n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...


US Patent US10800739 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%