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Patent code US10800757

Compile Data Set for Download or QSAR
Found 96 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466590
PNG
(US10800757, Compound 6 | [4-(6-Amino-pyridazin-3-y...)
Show SMILES COc1cc(ncc1Oc1ccc(OC(C)C)cc1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C25H29N5O4/c1-16(2)33-18-4-6-19(7-5-18)34-23-15-27-21(14-22(23)32-3)25(31)30-12-10-17(11-13-30)20-8-9-24(26)29-28-20/h4-9,14-17H,10-13H2,1-3H3,(H2,26,29)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466598
PNG
((6-Amino-3',4',5',6'-tetrahydro-2'H- [3,4']bipyrid...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCC(CC1)c1ccc(N)nc1
Show InChI InChI=1S/C23H23FN4O3/c1-30-20-12-19(26-14-21(20)31-18-5-3-17(24)4-6-18)23(29)28-10-8-15(9-11-28)16-2-7-22(25)27-13-16/h2-7,12-15H,8-11H2,1H3,(H2,25,27)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466599
PNG
(US10800757, Compound 15 | [4-(6-Amino-pyridin-3-yl...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCN(CC1)c1ccc(N)nc1
Show InChI InChI=1S/C22H23N5O3/c1-29-19-13-18(24-15-20(19)30-17-5-3-2-4-6-17)22(28)27-11-9-26(10-12-27)16-7-8-21(23)25-14-16/h2-8,13-15H,9-12H2,1H3,(H2,23,25)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466595
PNG
(US10800757, Compound 11 | [4-(6-Amino-5-methoxy-py...)
Show SMILES COc1cc(nnc1N)C1CCN(CC1)C(=O)c1cc(OC)c(Oc2ccc(F)cc2)cn1
Show InChI InChI=1S/C23H24FN5O4/c1-31-19-12-18(26-13-21(19)33-16-5-3-15(24)4-6-16)23(30)29-9-7-14(8-10-29)17-11-20(32-2)22(25)28-27-17/h3-6,11-14H,7-10H2,1-2H3,(H2,25,28)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466587
PNG
((6-Amino-3',4',5',6'-tetrahydro-2'H- [3,4']bipyrid...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCC(CC1)c1ccc(N)nc1
Show InChI InChI=1S/C23H24N4O3/c1-29-20-13-19(25-15-21(20)30-18-5-3-2-4-6-18)23(28)27-11-9-16(10-12-27)17-7-8-22(24)26-14-17/h2-8,13-16H,9-12H2,1H3,(H2,24,26)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466597
PNG
(US10800757, Compound 13 | [4-(6-Amino-pyridin-3-yl...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCN(CC1)c1ccc(N)nc1
Show InChI InChI=1S/C22H22FN5O3/c1-30-19-12-18(25-14-20(19)31-17-5-2-15(23)3-6-17)22(29)28-10-8-27(9-11-28)16-4-7-21(24)26-13-16/h2-7,12-14H,8-11H2,1H3,(H2,24,26)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466665
PNG
(US10800757, Compound 80 | [4-(6-Amino-pyridazin-3-...)
Show SMILES COc1cc(ncc1Oc1ccc(OC(F)(F)F)cc1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C23H22F3N5O4/c1-33-19-12-18(22(32)31-10-8-14(9-11-31)17-6-7-21(27)30-29-17)28-13-20(19)34-15-2-4-16(5-3-15)35-23(24,25)26/h2-7,12-14H,8-11H2,1H3,(H2,27,30)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466600
PNG
(US10800757, Compound 16 | [4-(6-Amino-pyridazin-3-...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C22H23N5O3/c1-29-19-13-18(24-14-20(19)30-16-5-3-2-4-6-16)22(28)27-11-9-15(10-12-27)17-7-8-21(23)26-25-17/h2-8,13-15H,9-12H2,1H3,(H2,23,26)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466588
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C24H25FN4O4/c1-31-20-12-23(26)28-13-18(20)15-7-9-29(10-8-15)24(30)19-11-21(32-2)22(14-27-19)33-17-5-3-16(25)4-6-17/h3-6,11-15H,7-10H2,1-2H3,(H2,26,28)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466593
PNG
(US10800757, Compound 9 | [7-(6-Amino-4-methoxy-pyr...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCN(CC11CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C25H26FN5O4/c1-33-20-12-23(27)29-13-19(20)30-9-10-31(25(15-30)7-8-25)24(32)18-11-21(34-2)22(14-28-18)35-17-5-3-16(26)4-6-17/h3-6,11-14H,7-10,15H2,1-2H3,(H2,27,29)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466596
PNG
(US10800757, Compound 12 | [4-(6-Amino-pyridin-3-yl...)
Show SMILES COc1ccc(Oc2cnc(cc2OC)C(=O)N2CCN(CC2)c2ccc(N)nc2)cc1
Show InChI InChI=1S/C23H25N5O4/c1-30-17-4-6-18(7-5-17)32-21-15-25-19(13-20(21)31-2)23(29)28-11-9-27(10-12-28)16-3-8-22(24)26-14-16/h3-8,13-15H,9-12H2,1-2H3,(H2,24,26)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466592
PNG
(US10800757, Compound 8 | [7-(6-Amino-4-methoxy-pyr...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCN(CC11CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C25H27N5O4/c1-32-20-13-23(26)28-14-19(20)29-10-11-30(25(16-29)8-9-25)24(31)18-12-21(33-2)22(15-27-18)34-17-6-4-3-5-7-17/h3-7,12-15H,8-11,16H2,1-2H3,(H2,26,28)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466589
PNG
(US10800757, Compound 5 | [4-(6-Amino-4-methoxy-pyr...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCN(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C23H25N5O4/c1-30-19-13-22(24)26-14-18(19)27-8-10-28(11-9-27)23(29)17-12-20(31-2)21(15-25-17)32-16-6-4-3-5-7-16/h3-7,12-15H,8-11H2,1-2H3,(H2,24,26)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466585
PNG
(US10800757, Compound 1 | [4-(6-Amino-4-methoxy-pyr...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCN(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C23H24FN5O4/c1-31-19-12-22(25)27-13-18(19)28-7-9-29(10-8-28)23(30)17-11-20(32-2)21(14-26-17)33-16-5-3-15(24)4-6-16/h3-6,11-14H,7-10H2,1-2H3,(H2,25,27)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466586
PNG
((6-Amino-4-methyl-3',4',5',6'- tetrahydro-2'H-[3,4...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCC(CC1)c1cnc(N)cc1C
Show InChI InChI=1S/C24H25FN4O3/c1-15-11-23(26)28-13-19(15)16-7-9-29(10-8-16)24(30)20-12-21(31-2)22(14-27-20)32-18-5-3-17(25)4-6-18/h3-6,11-14,16H,7-10H2,1-2H3,(H2,26,28)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466591
PNG
(US10800757, Compound 7 | [(R)-4-(6-Amino-4-methyl-...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCN(C[C@@H]1CO)c1cnc(N)cc1C
Show InChI InChI=1S/C24H26FN5O4/c1-15-9-23(26)28-11-20(15)29-7-8-30(17(13-29)14-31)24(32)19-10-21(33-2)22(12-27-19)34-18-5-3-16(25)4-6-18/h3-6,9-12,17,31H,7-8,13-14H2,1-2H3,(H2,26,28)/t17-/m1/s1
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466594
PNG
((6-Amino-4-methyl-3',4',5',6'- tetrahydro-2'H-[3,4...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCC(CC1)c1cnc(N)cc1C
Show InChI InChI=1S/C24H26N4O3/c1-16-12-23(25)27-14-19(16)17-8-10-28(11-9-17)24(29)20-13-21(30-2)22(15-26-20)31-18-6-4-3-5-7-18/h3-7,12-15,17H,8-11H2,1-2H3,(H2,25,27)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466601
PNG
(US10800757, Compound 17 | [4-(6-Amino-pyridazin-3-...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C22H22FN5O3/c1-30-19-12-18(25-13-20(19)31-16-4-2-15(23)3-5-16)22(29)28-10-8-14(9-11-28)17-6-7-21(24)27-26-17/h2-7,12-14H,8-11H2,1H3,(H2,24,27)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466602
PNG
(US10800757, Compound 18 | [(R)-4-(6-Amino-4-methyl...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCN(C[C@@H]1CO)c1cnc(N)cc1C
Show InChI InChI=1S/C24H27N5O4/c1-16-10-23(25)27-12-20(16)28-8-9-29(17(14-28)15-30)24(31)19-11-21(32-2)22(13-26-19)33-18-6-4-3-5-7-18/h3-7,10-13,17,30H,8-9,14-15H2,1-2H3,(H2,25,27)/t17-/m1/s1
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466603
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OCc1ccccc1F)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C25H27FN4O4/c1-32-21-12-24(27)29-13-18(21)16-7-9-30(10-8-16)25(31)20-11-22(33-2)23(14-28-20)34-15-17-5-3-4-6-19(17)26/h3-6,11-14,16H,7-10,15H2,1-2H3,(H2,27,29)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466604
PNG
(US10800757, Compound 20 | US10800757, Compound 81 ...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCN(C[C@@H]1CO)c1ccc(N)nc1
Show InChI InChI=1S/C23H24FN5O4/c1-32-20-10-19(26-12-21(20)33-18-5-2-15(24)3-6-18)23(31)29-9-8-28(13-17(29)14-30)16-4-7-22(25)27-11-16/h2-7,10-12,17,30H,8-9,13-14H2,1H3,(H2,25,27)/t17-/m1/s1
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466605
PNG
(US10800757, Compound 21 | [4-(6-Amino-5-methoxy-py...)
Show SMILES COc1cc(nnc1N)C1CCN(CC1)C(=O)c1cc(OC)c(Oc2ccccc2)cn1
Show InChI InChI=1S/C23H25N5O4/c1-30-19-13-18(25-14-21(19)32-16-6-4-3-5-7-16)23(29)28-10-8-15(9-11-28)17-12-20(31-2)22(24)27-26-17/h3-7,12-15H,8-11H2,1-2H3,(H2,24,27)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466606
PNG
((6-Amino-3',4',5',6'-tetrahydro-2'H- [3,4']bipyrid...)
Show SMILES COc1ccc(Oc2cnc(cc2OC)C(=O)N2CCC(CC2)c2ccc(N)nc2)cc1
Show InChI InChI=1S/C24H26N4O4/c1-30-18-4-6-19(7-5-18)32-22-15-26-20(13-21(22)31-2)24(29)28-11-9-16(10-12-28)17-3-8-23(25)27-14-17/h3-8,13-16H,9-12H2,1-2H3,(H2,25,27)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466634
PNG
((1R)-1-[(2R)-4-(6-amino-4- methoxypyridin-3-yl)-1-...)
Show SMILES COc1cc(N)ncc1N1CCN([C@H](C1)[C@@H](C)O)C(=O)c1ccc(Oc2ccccc2)cn1
Show InChI InChI=1S/C24H27N5O4/c1-16(30)21-15-28(20-14-27-23(25)12-22(20)32-2)10-11-29(21)24(31)19-9-8-18(13-26-19)33-17-6-4-3-5-7-17/h3-9,12-14,16,21,30H,10-11,15H2,1-2H3,(H2,25,27)/t16-,21-/m1/s1
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466607
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C24H26N4O4/c1-30-20-13-23(25)27-14-18(20)16-8-10-28(11-9-16)24(29)19-12-21(31-2)22(15-26-19)32-17-6-4-3-5-7-17/h3-7,12-16H,8-11H2,1-2H3,(H2,25,27)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466608
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1Oc1ccc(cc1)C(F)(F)F)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C25H25F3N4O4/c1-34-20-12-23(29)31-13-18(20)15-7-9-32(10-8-15)24(33)19-11-21(35-2)22(14-30-19)36-17-5-3-16(4-6-17)25(26,27)28/h3-6,11-15H,7-10H2,1-2H3,(H2,29,31)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466609
PNG
(US10800757, Compound 25 | [4-(6-Amino-pyridazin-3-...)
Show SMILES COc1cc(ncc1OCC1CCC1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C21H27N5O3/c1-28-18-11-17(23-12-19(18)29-13-14-3-2-4-14)21(27)26-9-7-15(8-10-26)16-5-6-20(22)25-24-16/h5-6,11-12,14-15H,2-4,7-10,13H2,1H3,(H2,22,25)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466604
PNG
(US10800757, Compound 20 | US10800757, Compound 81 ...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCN(C[C@@H]1CO)c1ccc(N)nc1
Show InChI InChI=1S/C23H24FN5O4/c1-32-20-10-19(26-12-21(20)33-18-5-2-15(24)3-6-18)23(31)29-9-8-28(13-17(29)14-30)16-4-7-22(25)27-11-16/h2-7,10-12,17,30H,8-9,13-14H2,1H3,(H2,25,27)/t17-/m1/s1
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466610
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OCC1(C)CC1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C23H30N4O4/c1-23(6-7-23)14-31-20-13-25-17(10-19(20)30-3)22(28)27-8-4-15(5-9-27)16-12-26-21(24)11-18(16)29-2/h10-13,15H,4-9,14H2,1-3H3,(H2,24,26)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466611
PNG
(US10800757, Compound 27 | [(R)-4-(6-Amino-4-methox...)
Show SMILES COC[C@H]1CN(CCN1C(=O)c1cc(OC)c(Oc2ccccc2)cn1)c1cnc(N)cc1OC
Show InChI InChI=1S/C25H29N5O5/c1-32-16-17-15-29(20-13-28-24(26)12-21(20)33-2)9-10-30(17)25(31)19-11-22(34-3)23(14-27-19)35-18-7-5-4-6-8-18/h4-8,11-14,17H,9-10,15-16H2,1-3H3,(H2,26,28)/t17-/m1/s1
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466617
PNG
(US10800757, Compound 33 | [4-(6-Amino-pyridazin-3-...)
Show SMILES COc1cc(ncc1Oc1ccc(cc1)C(F)(F)F)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C23H22F3N5O3/c1-33-19-12-18(28-13-20(19)34-16-4-2-15(3-5-16)23(24,25)26)22(32)31-10-8-14(9-11-31)17-6-7-21(27)30-29-17/h2-7,12-14H,8-11H2,1H3,(H2,27,30)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466618
PNG
(US10800757, Compound 34 | [4-(6-Amino-pyridazin-3-...)
Show SMILES COc1cc(ncc1Oc1ccc(Cl)cc1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C22H22ClN5O3/c1-30-19-12-18(25-13-20(19)31-16-4-2-15(23)3-5-16)22(29)28-10-8-14(9-11-28)17-6-7-21(24)27-26-17/h2-7,12-14H,8-11H2,1H3,(H2,24,27)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466619
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OC1CCCC1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C23H30N4O4/c1-29-19-12-22(24)26-13-17(19)15-7-9-27(10-8-15)23(28)18-11-20(30-2)21(14-25-18)31-16-5-3-4-6-16/h11-16H,3-10H2,1-2H3,(H2,24,26)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466620
PNG
(US10800757, Compound 36 | [4-(6-Amino-pyridazin-3-...)
Show SMILES COc1cc(ncc1OCC(C)C)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C20H27N5O3/c1-13(2)12-28-18-11-22-16(10-17(18)27-3)20(26)25-8-6-14(7-9-25)15-4-5-19(21)24-23-15/h4-5,10-11,13-14H,6-9,12H2,1-3H3,(H2,21,24)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466668
PNG
(US10800757, Compound 83 | [4-(6-Amino-pyridazin-3-...)
Show SMILES CCOc1cc(ncc1Oc1ccccc1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C23H25N5O3/c1-2-30-20-14-19(25-15-21(20)31-17-6-4-3-5-7-17)23(29)28-12-10-16(11-13-28)18-8-9-22(24)27-26-18/h3-9,14-16H,2,10-13H2,1H3,(H2,24,27)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466612
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1ccc(Oc2cnc(cc2OC)C(=O)N2CCC(CC2)c2cnc(N)cc2OC)cc1
Show InChI InChI=1S/C25H28N4O5/c1-31-17-4-6-18(7-5-17)34-23-15-27-20(12-22(23)33-3)25(30)29-10-8-16(9-11-29)19-14-28-24(26)13-21(19)32-2/h4-7,12-16H,8-11H2,1-3H3,(H2,26,28)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466642
PNG
((1S)-1-[(2R)-4-(6-amino-4- methoxypyridin-3-yl)-1-...)
Show SMILES COc1cc(N)ncc1N1CCN([C@H](C1)[C@H](C)O)C(=O)c1ccc(Oc2ccccc2)cn1
Show InChI InChI=1S/C24H27N5O4/c1-16(30)21-15-28(20-14-27-23(25)12-22(20)32-2)10-11-29(21)24(31)19-9-8-18(13-26-19)33-17-6-4-3-5-7-17/h3-9,12-14,16,21,30H,10-11,15H2,1-2H3,(H2,25,27)/t16-,21+/m0/s1
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466614
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OC1CCCCC1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C24H32N4O4/c1-30-20-13-23(25)27-14-18(20)16-8-10-28(11-9-16)24(29)19-12-21(31-2)22(15-26-19)32-17-6-4-3-5-7-17/h12-17H,3-11H2,1-2H3,(H2,25,27)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466613
PNG
(6-{-[5-(4-Fluorophenoxy)-4-methoxypyridine-2-carbo...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCC(CC1)c1nnc(N)cc1C
Show InChI InChI=1S/C23H24FN5O3/c1-14-11-21(25)27-28-22(14)15-7-9-29(10-8-15)23(30)18-12-19(31-2)20(13-26-18)32-17-5-3-16(24)4-6-17/h3-6,11-13,15H,7-10H2,1-2H3,(H2,25,27)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466615
PNG
(6-[1-(4-Methoxy-5-phenoxypyridine-2-carbonyl)piper...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCC(CC1)c1nnc(N)cc1C
Show InChI InChI=1S/C23H25N5O3/c1-15-12-21(24)26-27-22(15)16-8-10-28(11-9-16)23(29)18-13-19(30-2)20(14-25-18)31-17-6-4-3-5-7-17/h3-7,12-14,16H,8-11H2,1-2H3,(H2,24,26)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466616
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OCc1ccc(F)cc1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C25H27FN4O4/c1-32-21-12-24(27)29-13-19(21)17-7-9-30(10-8-17)25(31)20-11-22(33-2)23(14-28-20)34-15-16-3-5-18(26)6-4-16/h3-6,11-14,17H,7-10,15H2,1-2H3,(H2,27,29)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466627
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OCc1ccccc1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C25H28N4O4/c1-31-21-13-24(26)28-14-19(21)18-8-10-29(11-9-18)25(30)20-12-22(32-2)23(15-27-20)33-16-17-6-4-3-5-7-17/h3-7,12-15,18H,8-11,16H2,1-2H3,(H2,26,28)
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n/an/a 140n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466626
PNG
(US10800757, Compound 42 | [(R)-4-(6-Amino-4-methox...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCN(C[C@@H]1CO)c1cnc(N)cc1OC
Show InChI InChI=1S/C24H26FN5O5/c1-33-20-10-23(26)28-11-19(20)29-7-8-30(16(13-29)14-31)24(32)18-9-21(34-2)22(12-27-18)35-17-5-3-15(25)4-6-17/h3-6,9-12,16,31H,7-8,13-14H2,1-2H3,(H2,26,28)/t16-/m1/s1
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n/an/a 140n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466628
PNG
(US10800757, Compound 44 | [4-(6-Amino-pyridazin-3-...)
Show SMILES COc1ccc(Oc2cnc(cc2OC)C(=O)N2CCC(CC2)c2ccc(N)nn2)cc1
Show InChI InChI=1S/C23H25N5O4/c1-30-16-3-5-17(6-4-16)32-21-14-25-19(13-20(21)31-2)23(29)28-11-9-15(10-12-28)18-7-8-22(24)27-26-18/h3-8,13-15H,9-12H2,1-2H3,(H2,24,27)
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n/an/a 140n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466629
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OCC1CC(F)(F)C1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C23H28F2N4O4/c1-31-18-8-21(26)28-11-16(18)15-3-5-29(6-4-15)22(30)17-7-19(32-2)20(12-27-17)33-13-14-9-23(24,25)10-14/h7-8,11-12,14-15H,3-6,9-10,13H2,1-2H3,(H2,26,28)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466621
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OCC1CC1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C22H28N4O4/c1-28-18-10-21(23)25-11-16(18)15-5-7-26(8-6-15)22(27)17-9-19(29-2)20(12-24-17)30-13-14-3-4-14/h9-12,14-15H,3-8,13H2,1-2H3,(H2,23,25)
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n/an/a 160n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466630
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES CCCOc1cnc(cc1OC)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C21H28N4O4/c1-4-9-29-19-13-23-16(10-18(19)28-3)21(26)25-7-5-14(6-8-25)15-12-24-20(22)11-17(15)27-2/h10-14H,4-9H2,1-3H3,(H2,22,24)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466623
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OCC(C)C)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C22H30N4O4/c1-14(2)13-30-20-12-24-17(9-19(20)29-4)22(27)26-7-5-15(6-8-26)16-11-25-21(23)10-18(16)28-3/h9-12,14-15H,5-8,13H2,1-4H3,(H2,23,25)
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n/an/a 170n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466622
PNG
(US10800757, Compound 38 | [3-(6-Amino-4-methoxy-py...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1C2CCC1CN(C2)c1cnc(N)cc1OC
Show InChI InChI=1S/C25H26FN5O4/c1-33-21-10-24(27)29-11-20(21)30-13-16-5-6-17(14-30)31(16)25(32)19-9-22(34-2)23(12-28-19)35-18-7-3-15(26)4-8-18/h3-4,7-12,16-17H,5-6,13-14H2,1-2H3,(H2,27,29)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466624
PNG
(US10800757, Compound 40 | [4-(6-Amino-pyridazin-3-...)
Show SMILES COc1cc(ncc1Oc1ccc(OC2CC2)cc1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C25H27N5O4/c1-32-22-14-21(25(31)30-12-10-16(11-13-30)20-8-9-24(26)29-28-20)27-15-23(22)34-19-6-4-18(5-7-19)33-17-2-3-17/h4-9,14-17H,2-3,10-13H2,1H3,(H2,26,29)
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n/an/a 170n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466625
PNG
(US10800757, Compound 41 | [4-(6-Amino-pyridazin-3-...)
Show SMILES COc1cc(ncc1OCc1ccc(F)cc1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C23H24FN5O3/c1-31-20-12-19(26-13-21(20)32-14-15-2-4-17(24)5-3-15)23(30)29-10-8-16(9-11-29)18-6-7-22(25)28-27-18/h2-7,12-13,16H,8-11,14H2,1H3,(H2,25,28)
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n/an/a 180n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466667
PNG
(US10800757, Compound 82 | [(R)-4-(6-Amino-pyridin-...)
Show SMILES COc1ccc(Oc2cnc(cc2OC)C(=O)N2CCN(C[C@@H]2CO)c2ccc(N)nc2)cc1
Show InChI InChI=1S/C24H27N5O5/c1-32-18-4-6-19(7-5-18)34-22-13-26-20(11-21(22)33-2)24(31)29-10-9-28(14-17(29)15-30)16-3-8-23(25)27-12-16/h3-8,11-13,17,30H,9-10,14-15H2,1-2H3,(H2,25,27)/t17-/m1/s1
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n/an/a 180n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466636
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OCCc1ccccc1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C26H30N4O4/c1-32-22-15-25(27)29-16-20(22)19-8-11-30(12-9-19)26(31)21-14-23(33-2)24(17-28-21)34-13-10-18-6-4-3-5-7-18/h3-7,14-17,19H,8-13H2,1-2H3,(H2,27,29)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466637
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OCC1CCC1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C23H30N4O4/c1-29-19-11-22(24)26-12-17(19)16-6-8-27(9-7-16)23(28)18-10-20(30-2)21(13-25-18)31-14-15-4-3-5-15/h10-13,15-16H,3-9,14H2,1-2H3,(H2,24,26)
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n/an/a 210n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466638
PNG
(US10800757, Compound 54 | [4-(6-Amino-pyridazin-3-...)
Show SMILES COc1cc(ncc1Oc1ccc(OC(F)F)cc1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C23H23F2N5O4/c1-32-19-12-18(27-13-20(19)33-15-2-4-16(5-3-15)34-23(24)25)22(31)30-10-8-14(9-11-30)17-6-7-21(26)29-28-17/h2-7,12-14,23H,8-11H2,1H3,(H2,26,29)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466631
PNG
(US10800757, Compound 47 | [4-(6-Amino-4-methoxy-py...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCC(CC1)c1nnc(N)cc1OC
Show InChI InChI=1S/C23H25N5O4/c1-30-18-12-17(25-14-20(18)32-16-6-4-3-5-7-16)23(29)28-10-8-15(9-11-28)22-19(31-2)13-21(24)26-27-22/h3-7,12-15H,8-11H2,1-2H3,(H2,24,26)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466639
PNG
(US10800757, Compound 55 | [(R)-4-(6-Amino-4-methox...)
Show SMILES COC[C@H]1CN(CCN1C(=O)c1cc(OC)c(Oc2ccc(F)cc2)cn1)c1cnc(N)cc1OC
Show InChI InChI=1S/C25H28FN5O5/c1-33-15-17-14-30(20-12-29-24(27)11-21(20)34-2)8-9-31(17)25(32)19-10-22(35-3)23(13-28-19)36-18-6-4-16(26)5-7-18/h4-7,10-13,17H,8-9,14-15H2,1-3H3,(H2,27,29)/t17-/m1/s1
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466632
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OCCC1CC1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C23H30N4O4/c1-29-19-12-22(24)26-13-17(19)16-5-8-27(9-6-16)23(28)18-11-20(30-2)21(14-25-18)31-10-7-15-3-4-15/h11-16H,3-10H2,1-2H3,(H2,24,26)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466633
PNG
(US10800757, Compound 49 | [4-(6-Amino-4-methoxy-py...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCC(CC1)c1nnc(N)cc1OC
Show InChI InChI=1S/C23H24FN5O4/c1-31-18-11-17(26-13-20(18)33-16-5-3-15(24)4-6-16)23(30)29-9-7-14(8-10-29)22-19(32-2)12-21(25)27-28-22/h3-6,11-14H,7-10H2,1-2H3,(H2,25,27)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466635
PNG
(US10800757, Compound 51 | [3-(6-Amino-4-methoxy-py...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1C2CCC1CN(C2)c1cnc(N)cc1OC
Show InChI InChI=1S/C25H27N5O4/c1-32-21-11-24(26)28-12-20(21)29-14-16-8-9-17(15-29)30(16)25(31)19-10-22(33-2)23(13-27-19)34-18-6-4-3-5-7-18/h3-7,10-13,16-17H,8-9,14-15H2,1-2H3,(H2,26,28)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466640
PNG
(US10800757, Compound 56 | [4-(6-Amino-4-methoxy-py...)
Show SMILES COc1cc(ncc1Oc1ccc(cc1)C(F)(F)F)C(=O)N1CCC(CC1)c1nnc(N)cc1OC
Show InChI InChI=1S/C24H24F3N5O4/c1-34-18-11-17(29-13-20(18)36-16-5-3-15(4-6-16)24(25,26)27)23(33)32-9-7-14(8-10-32)22-19(35-2)12-21(28)30-31-22/h3-6,11-14H,7-10H2,1-2H3,(H2,28,30)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466669
PNG
((6-Amino-4-cyclopropoxy-3',4',5',6'- tetrahydro-2'...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC1CC1
Show InChI InChI=1S/C26H28N4O4/c1-32-23-13-21(28-16-24(23)34-18-5-3-2-4-6-18)26(31)30-11-9-17(10-12-30)20-15-29-25(27)14-22(20)33-19-7-8-19/h2-6,13-17,19H,7-12H2,1H3,(H2,27,29)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466641
PNG
(US10800757, Compound 57 | [4-(6-Amino-pyridazin-3-...)
Show SMILES COc1cc(ncc1OCc1ccccc1F)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C23H24FN5O3/c1-31-20-12-19(26-13-21(20)32-14-16-4-2-3-5-17(16)24)23(30)29-10-8-15(9-11-29)18-6-7-22(25)28-27-18/h2-7,12-13,15H,8-11,14H2,1H3,(H2,25,28)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466670
PNG
(US10800757, Compound 85 | [4-(6-Amino-4-ethoxy-pyr...)
Show SMILES CCOc1cc(N)nnc1C1CCN(CC1)C(=O)c1cc(OC)c(Oc2ccccc2)cn1
Show InChI InChI=1S/C24H27N5O4/c1-3-32-20-14-22(25)27-28-23(20)16-9-11-29(12-10-16)24(30)18-13-19(31-2)21(15-26-18)33-17-7-5-4-6-8-17/h4-8,13-16H,3,9-12H2,1-2H3,(H2,25,27)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466643
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OCC(C)(C)C)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C23H32N4O4/c1-23(2,3)14-31-20-13-25-17(10-19(20)30-5)22(28)27-8-6-15(7-9-27)16-12-26-21(24)11-18(16)29-4/h10-13,15H,6-9,14H2,1-5H3,(H2,24,26)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466679
PNG
(US10800757, Compound 94a | US10800757, Compound 94...)
Show SMILES COc1cc(ncc1OCC(C)C(F)(F)F)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C22H27F3N4O4/c1-13(22(23,24)25)12-33-19-11-27-16(8-18(19)32-3)21(30)29-6-4-14(5-7-29)15-10-28-20(26)9-17(15)31-2/h8-11,13-14H,4-7,12H2,1-3H3,(H2,26,28)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466671
PNG
((6-Amino-4-propoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES CCCOc1cc(N)ncc1C1CCN(CC1)C(=O)c1cc(OC)c(Oc2ccccc2)cn1
Show InChI InChI=1S/C26H30N4O4/c1-3-13-33-22-15-25(27)29-16-20(22)18-9-11-30(12-10-18)26(31)21-14-23(32-2)24(17-28-21)34-19-7-5-4-6-8-19/h4-8,14-18H,3,9-13H2,1-2H3,(H2,27,29)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466679
PNG
(US10800757, Compound 94a | US10800757, Compound 94...)
Show SMILES COc1cc(ncc1OCC(C)C(F)(F)F)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C22H27F3N4O4/c1-13(22(23,24)25)12-33-19-11-27-16(8-18(19)32-3)21(30)29-6-4-14(5-7-29)15-10-28-20(26)9-17(15)31-2/h8-11,13-14H,4-7,12H2,1-3H3,(H2,26,28)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466675
PNG
(6-(1-{4-Methoxy-5-[4- (trifluoromethyl)phenoxy]pyr...)
Show SMILES COc1cc(ncc1Oc1ccc(cc1)C(F)(F)F)C(=O)N1CCC(CC1)c1nnc(N)cc1C
Show InChI InChI=1S/C24H24F3N5O3/c1-14-11-21(28)30-31-22(14)15-7-9-32(10-8-15)23(33)18-12-19(34-2)20(13-29-18)35-17-5-3-16(4-6-17)24(25,26)27/h3-6,11-13,15H,7-10H2,1-2H3,(H2,28,30)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466676
PNG
(5-Methoxy-6-(1-{5-[4- (trifluoromethyl)-phenoxy]-p...)
Show SMILES COc1cc(N)nnc1C1CCN(CC1)C(=O)c1ccc(Oc2ccc(cc2)C(F)(F)F)cn1
Show InChI InChI=1S/C23H22F3N5O3/c1-33-19-12-20(27)29-30-21(19)14-8-10-31(11-9-14)22(32)18-7-6-17(13-28-18)34-16-4-2-15(3-5-16)23(24,25)26/h2-7,12-14H,8-11H2,1H3,(H2,27,29)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466644
PNG
(US10800757, Compound 60 | [4-(6-Amino-5-methoxy-py...)
Show SMILES COc1ccc(Oc2cnc(cc2OC)C(=O)N2CCC(CC2)c2cc(OC)c(N)nn2)cc1
Show InChI InChI=1S/C24H27N5O5/c1-31-16-4-6-17(7-5-16)34-22-14-26-19(13-20(22)32-2)24(30)29-10-8-15(9-11-29)18-12-21(33-3)23(25)28-27-18/h4-7,12-15H,8-11H2,1-3H3,(H2,25,28)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466681
PNG
(5-(1-{5-[(2,2-Difluorocyclobutyl)- methoxy]-4-meth...)
Show SMILES COc1cc(ncc1OCC1CCC1(F)F)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C23H28F2N4O4/c1-31-18-10-21(26)28-11-16(18)14-4-7-29(8-5-14)22(30)17-9-19(32-2)20(12-27-17)33-13-15-3-6-23(15,24)25/h9-12,14-15H,3-8,13H2,1-2H3,(H2,26,28)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466645
PNG
(US10800757, Compound 61 | [4-(6-Amino-4-methoxy-py...)
Show SMILES COc1cc(ncc1OCC1CC1)C(=O)N1CCN(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C21H27N5O4/c1-28-17-10-20(22)24-11-16(17)25-5-7-26(8-6-25)21(27)15-9-18(29-2)19(12-23-15)30-13-14-3-4-14/h9-12,14H,3-8,13H2,1-2H3,(H2,22,24)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466646
PNG
(US10800757, Compound 62 | [4-(6-Amino-pyridazin-3-...)
Show SMILES COc1cc(ncc1OC1CCCCC1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C22H29N5O3/c1-29-19-13-18(24-14-20(19)30-16-5-3-2-4-6-16)22(28)27-11-9-15(10-12-27)17-7-8-21(23)26-25-17/h7-8,13-16H,2-6,9-12H2,1H3,(H2,23,26)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466651
PNG
(US10800757, Compound 67 | [4-(6-Amino-pyridazin-3-...)
Show SMILES COc1cc(ncc1OCCC1CC1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C21H27N5O3/c1-28-18-12-17(23-13-19(18)29-11-8-14-2-3-14)21(27)26-9-6-15(7-10-26)16-4-5-20(22)25-24-16/h4-5,12-15H,2-3,6-11H2,1H3,(H2,22,25)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466678
PNG
(4-Methoxy-5-[1-(4-methoxy-5-{[(cis- 3-(trifluorome...)
Show SMILES COc1cc(ncc1OC[C@H]1C[C@H](C1)C(F)(F)F)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C24H29F3N4O4/c1-33-19-10-22(28)30-11-17(19)15-3-5-31(6-4-15)23(32)18-9-20(34-2)21(12-29-18)35-13-14-7-16(8-14)24(25,26)27/h9-12,14-16H,3-8,13H2,1-2H3,(H2,28,30)/t14-,16+
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466672
PNG
((6-Amino-4-ethoxy-3',4',5',6'- tetrahydro-2'H-[3,4...)
Show SMILES CCOc1cc(N)nnc1C1CCN(CC1)C(=O)c1cc(OC)c(Oc2ccc(cc2)C(F)(F)F)cn1
Show InChI InChI=1S/C25H26F3N5O4/c1-3-36-20-13-22(29)31-32-23(20)15-8-10-33(11-9-15)24(34)18-12-19(35-2)21(14-30-18)37-17-6-4-16(5-7-17)25(26,27)28/h4-7,12-15H,3,8-11H2,1-2H3,(H2,29,31)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466653
PNG
(US10800757, Compound 69 | [(R)-4-(6-Amino-4-methox...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCN(C[C@@H]1CO)c1cnc(N)cc1OC
Show InChI InChI=1S/C24H27N5O5/c1-32-20-11-23(25)27-12-19(20)28-8-9-29(16(14-28)15-30)24(31)18-10-21(33-2)22(13-26-18)34-17-6-4-3-5-7-17/h3-7,10-13,16,30H,8-9,14-15H2,1-2H3,(H2,25,27)/t16-/m1/s1
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466652
PNG
(US10800757, Compound 68 | [7-(6-Amino-4-methoxy-py...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1C2COCC1CC(C2)c1cnc(N)cc1OC
Show InChI InChI=1S/C26H28N4O5/c1-32-22-11-25(27)29-12-20(22)16-8-17-14-34-15-18(9-16)30(17)26(31)21-10-23(33-2)24(13-28-21)35-19-6-4-3-5-7-19/h3-7,10-13,16-18H,8-9,14-15H2,1-2H3,(H2,27,29)
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466677
PNG
(4-Methoxy-5-[1-(4-methoxy-5-{[trans- 3-(trifluorom...)
Show SMILES COc1cc(ncc1OC[C@H]1C[C@@H](C1)C(F)(F)F)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C24H29F3N4O4/c1-33-19-10-22(28)30-11-17(19)15-3-5-31(6-4-15)23(32)18-9-20(34-2)21(12-29-18)35-13-14-7-16(8-14)24(25,26)27/h9-12,14-16H,3-8,13H2,1-2H3,(H2,28,30)/t14-,16-
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466654
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1O[C@@H](C)C1CC1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C23H30N4O4/c1-14(15-4-5-15)31-21-13-25-18(10-20(21)30-3)23(28)27-8-6-16(7-9-27)17-12-26-22(24)11-19(17)29-2/h10-16H,4-9H2,1-3H3,(H2,24,26)/t14-/m0/s1
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Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466647
PNG
(US10800757, Compound 63 | [(S)-4-(6-Amino-4-methox...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCN(C[C@H]1CO)c1cnc(N)cc1OC
Show InChI InChI=1S/C24H26FN5O5/c1-33-20-10-23(26)28-11-19(20)29-7-8-30(16(13-29)14-31)24(32)18-9-21(34-2)22(12-27-18)35-17-5-3-15(25)4-6-17/h3-6,9-12,16,31H,7-8,13-14H2,1-2H3,(H2,26,28)/t16-/m0/s1
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n/an/a 670n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466673
PNG
(US10800757, Compound 88 | [4-(6-Amino-pyridazin-3-...)
Show SMILES CCOc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C23H24FN5O3/c1-2-31-20-13-19(26-14-21(20)32-17-5-3-16(24)4-6-17)23(30)29-11-9-15(10-12-29)18-7-8-22(25)28-27-18/h3-8,13-15H,2,9-12H2,1H3,(H2,25,28)
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n/an/a 750n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466648
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OCC1(CF)CC1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C23H29FN4O4/c1-30-18-10-21(25)27-11-16(18)15-3-7-28(8-4-15)22(29)17-9-19(31-2)20(12-26-17)32-14-23(13-24)5-6-23/h9-12,15H,3-8,13-14H2,1-2H3,(H2,25,27)
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n/an/a 820n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466649
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES CCOc1cnc(cc1OC)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C20H26N4O4/c1-4-28-18-12-22-15(9-17(18)27-3)20(25)24-7-5-13(6-8-24)14-11-23-19(21)10-16(14)26-2/h9-13H,4-8H2,1-3H3,(H2,21,23)
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n/an/a 830n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466650
PNG
(US10800757, Compound 66 | [4-(6-Amino-4-methoxy-py...)
Show SMILES COc1ccc(Oc2cnc(cc2OC)C(=O)N2CCC(CC2)c2nnc(N)cc2OC)cc1
Show InChI InChI=1S/C24H27N5O5/c1-31-16-4-6-17(7-5-16)34-21-14-26-18(12-19(21)32-2)24(30)29-10-8-15(9-11-29)23-20(33-3)13-22(25)27-28-23/h4-7,12-15H,8-11H2,1-3H3,(H2,25,27)
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n/an/a 840n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466655
PNG
(US10800757, Compound 71 | [(S)-4-(6-Amino-4-methox...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCN(C[C@H]1CO)c1cnc(N)cc1OC
Show InChI InChI=1S/C24H27N5O5/c1-32-20-11-23(25)27-12-19(20)28-8-9-29(16(14-28)15-30)24(31)18-10-21(33-2)22(13-26-18)34-17-6-4-3-5-7-17/h3-7,10-13,16,30H,8-9,14-15H2,1-2H3,(H2,25,27)/t16-/m0/s1
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n/an/a 850n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466656
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OC(C)C)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C21H28N4O4/c1-13(2)29-19-12-23-16(9-18(19)28-4)21(26)25-7-5-14(6-8-25)15-11-24-20(22)10-17(15)27-3/h9-14H,5-8H2,1-4H3,(H2,22,24)
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n/an/a 910n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466657
PNG
(US10800757, Compound 73 | [4-(6-Amino-pyridazin-3-...)
Show SMILES COc1cc(ncc1OCCc1ccccc1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C24H27N5O3/c1-31-21-15-20(26-16-22(21)32-14-11-17-5-3-2-4-6-17)24(30)29-12-9-18(10-13-29)19-7-8-23(25)28-27-19/h2-8,15-16,18H,9-14H2,1H3,(H2,25,28)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466658
PNG
(US10800757, Compound 74 | [4-(6-Amino-pyridazin-3-...)
Show SMILES COc1cc(ncc1OCC(C)(C)C)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C21H29N5O3/c1-21(2,3)13-29-18-12-23-16(11-17(18)28-4)20(27)26-9-7-14(8-10-26)15-5-6-19(22)25-24-15/h5-6,11-12,14H,7-10,13H2,1-4H3,(H2,22,25)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466660
PNG
(US10800757, Compound 75 | [4-(6-Amino-pyridazin-3-...)
Show SMILES COc1cc(ncc1OCC1(C)CC1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C21H27N5O3/c1-21(7-8-21)13-29-18-12-23-16(11-17(18)28-2)20(27)26-9-5-14(6-10-26)15-3-4-19(22)25-24-15/h3-4,11-12,14H,5-10,13H2,1-2H3,(H2,22,25)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466661
PNG
(US10800757, Compound 76 | [4-(6-Amino-pyridazin-3-...)
Show SMILES CCCOc1cnc(cc1OC)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C19H25N5O3/c1-3-10-27-17-12-21-15(11-16(17)26-2)19(25)24-8-6-13(7-9-24)14-4-5-18(20)23-22-14/h4-5,11-13H,3,6-10H2,1-2H3,(H2,20,23)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466674
PNG
(US10800757, Compound 89 | [3-(6-Amino-pyridazin-3-...)
Show SMILES CCOc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1C2CCC1CC(C2)c1ccc(N)nn1
Show InChI InChI=1S/C25H26FN5O3/c1-2-33-22-13-21(28-14-23(22)34-19-7-3-16(26)4-8-19)25(32)31-17-5-6-18(31)12-15(11-17)20-9-10-24(27)30-29-20/h3-4,7-10,13-15,17-18H,2,5-6,11-12H2,1H3,(H2,27,30)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466662
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1O[C@H](C)C1CC1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C23H30N4O4/c1-14(15-4-5-15)31-21-13-25-18(10-20(21)30-3)23(28)27-8-6-16(7-9-27)17-12-26-22(24)11-19(17)29-2/h10-16H,4-9H2,1-3H3,(H2,24,26)/t14-/m1/s1
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n/an/a 2.20E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466663
PNG
(US10800757, Compound 78 | [4-(6-Amino-4-methyl-pyr...)
Show SMILES COc1cc(ncc1OCC1CC1)C(=O)N1CCC(CC1)c1nnc(N)cc1C
Show InChI InChI=1S/C21H27N5O3/c1-13-9-19(22)24-25-20(13)15-5-7-26(8-6-15)21(27)16-10-17(28-2)18(11-23-16)29-12-14-3-4-14/h9-11,14-15H,3-8,12H2,1-2H3,(H2,22,24)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466664
PNG
(US10800757, Compound 79 | [4-(6-Amino-pyridazin-3-...)
Show SMILES COc1cc(ncc1O[C@@H](C)C1CC1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C21H27N5O3/c1-13(14-3-4-14)29-19-12-23-17(11-18(19)28-2)21(27)26-9-7-15(8-10-26)16-5-6-20(22)25-24-16/h5-6,11-15H,3-4,7-10H2,1-2H3,(H2,22,25)/t13-/m0/s1
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n/an/a 3.70E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC

US Patent


Assay Description
This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...


US Patent US10800757 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%