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Patent code US10800764

Compile Data Set for Download or QSAR
Found 23 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony stimulating factor receptor


()
BDBM276745
PNG
(US10071991, Compound (I-M2-2R,4S) | US10800764, Co...)
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@H]1CC(C)(C)O[C@](C)(C1)C(O)=O
PDB
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n/an/a 1.80n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...


US Patent US10800764 (2020)

More data for this
Ligand-Target Pair
Receptor protein-tyrosine kinase


(Dog)
BDBM276745
PNG
(US10071991, Compound (I-M2-2R,4S) | US10800764, Co...)
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@H]1CC(C)(C)O[C@](C)(C1)C(O)=O
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n/an/a 2n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...


US Patent US10800764 (2020)

More data for this
Ligand-Target Pair
Receptor protein-tyrosine kinase


(Dog)
BDBM276744
PNG
(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@@H]1CC(C)(C)O[C@@](C)(C1)C(O)=O
UniProtKB/TrEMBL

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UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...


US Patent US10800764 (2020)

More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Rattus norvegicus (Rat))
BDBM276744
PNG
(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@@H]1CC(C)(C)O[C@@](C)(C1)C(O)=O
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n/an/a 2.20n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...


US Patent US10800764 (2020)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


()
BDBM276744
PNG
(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@@H]1CC(C)(C)O[C@@](C)(C1)C(O)=O
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n/an/a 2.20n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...


US Patent US10800764 (2020)

More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Rattus norvegicus (Rat))
BDBM276745
PNG
(US10071991, Compound (I-M2-2R,4S) | US10800764, Co...)
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@H]1CC(C)(C)O[C@](C)(C1)C(O)=O
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n/an/a 2.5n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...


US Patent US10800764 (2020)

More data for this
Ligand-Target Pair
Receptor protein-tyrosine kinase


(Dog)
BDBM466797
PNG
(US10800764, Compound (I-M7-2S,4R))
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@@H]1CC(C)(C)O[C@](C)(C1)C(O)=O
UniProtKB/TrEMBL

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n/an/a 6.60n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...


US Patent US10800764 (2020)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


()
BDBM276744
PNG
(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@@H]1CC(C)(C)O[C@@](C)(C1)C(O)=O
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n/an/a 7.10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...


US Patent US10800764 (2020)

More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Rattus norvegicus (Rat))
BDBM466797
PNG
(US10800764, Compound (I-M7-2S,4R))
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@@H]1CC(C)(C)O[C@](C)(C1)C(O)=O
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n/an/a 7.90n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...


US Patent US10800764 (2020)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


()
BDBM466797
PNG
(US10800764, Compound (I-M7-2S,4R))
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@@H]1CC(C)(C)O[C@](C)(C1)C(O)=O
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n/an/a 7.90n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...


US Patent US10800764 (2020)

More data for this
Ligand-Target Pair
Receptor protein-tyrosine kinase


(Dog)
BDBM276744
PNG
(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@@H]1CC(C)(C)O[C@@](C)(C1)C(O)=O
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n/an/a 8n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...


US Patent US10800764 (2020)

More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Rattus norvegicus (Rat))
BDBM276744
PNG
(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@@H]1CC(C)(C)O[C@@](C)(C1)C(O)=O
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n/an/a 9.60n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...


US Patent US10800764 (2020)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


()
BDBM276743
PNG
(US10071991, Compound (P) | US10800764, Compound (P...)
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1CC(C)(C)OC(C)(C)C1
Show InChI InChI=1S/C27H35N5O2/c1-25(2)11-9-17(10-12-25)22-21(32-24(33)23-29-16-19(15-28)30-23)8-7-20(31-22)18-13-26(3,4)34-27(5,6)14-18/h7-9,16,18H,10-14H2,1-6H3,(H,29,30)(H,32,33)
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n/an/a 10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...


US Patent US10800764 (2020)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


()
BDBM466793
PNG
(US10800764, Compound (I-M7))
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@@H]1CC(C)(C)OC(C)(CO)C1
PDB
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n/an/a 10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
c-fms(h) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx...


US Patent US10800764 (2020)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


()
BDBM276741
PNG
(US10071991, Compound (I-M2) | US10800764, Compound...)
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1CC(C)(C)OC(C)(C1)C(O)=O
PDB
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n/an/a 11n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
c-fms(h) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx...


US Patent US10800764 (2020)

More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Rattus norvegicus (Rat))
BDBM276743
PNG
(US10071991, Compound (P) | US10800764, Compound (P...)
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1CC(C)(C)OC(C)(C)C1
Show InChI InChI=1S/C27H35N5O2/c1-25(2)11-9-17(10-12-25)22-21(32-24(33)23-29-16-19(15-28)30-23)8-7-20(31-22)18-13-26(3,4)34-27(5,6)14-18/h7-9,16,18H,10-14H2,1-6H3,(H,29,30)(H,32,33)
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n/an/a 11n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...


US Patent US10800764 (2020)

More data for this
Ligand-Target Pair
Receptor protein-tyrosine kinase


(Dog)
BDBM276743
PNG
(US10071991, Compound (P) | US10800764, Compound (P...)
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1CC(C)(C)OC(C)(C)C1
Show InChI InChI=1S/C27H35N5O2/c1-25(2)11-9-17(10-12-25)22-21(32-24(33)23-29-16-19(15-28)30-23)8-7-20(31-22)18-13-26(3,4)34-27(5,6)14-18/h7-9,16,18H,10-14H2,1-6H3,(H,29,30)(H,32,33)
UniProtKB/TrEMBL

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n/an/a 16n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...


US Patent US10800764 (2020)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


()
BDBM276743
PNG
(US10071991, Compound (P) | US10800764, Compound (P...)
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1CC(C)(C)OC(C)(C)C1
Show InChI InChI=1S/C27H35N5O2/c1-25(2)11-9-17(10-12-25)22-21(32-24(33)23-29-16-19(15-28)30-23)8-7-20(31-22)18-13-26(3,4)34-27(5,6)14-18/h7-9,16,18H,10-14H2,1-6H3,(H,29,30)(H,32,33)
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n/an/a 18n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
c-fms(h) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx...


US Patent US10800764 (2020)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


()
BDBM466797
PNG
(US10800764, Compound (I-M7-2S,4R))
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@@H]1CC(C)(C)O[C@](C)(C1)C(O)=O
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n/an/a 1.00E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Representative compounds of the present invention were additionally tested in an in vitro assay measuring inhibition of CSF-1 induced monocyte MCP-1 ...


US Patent US10800764 (2020)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


()
BDBM276743
PNG
(US10071991, Compound (P) | US10800764, Compound (P...)
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1CC(C)(C)OC(C)(C)C1
Show InChI InChI=1S/C27H35N5O2/c1-25(2)11-9-17(10-12-25)22-21(32-24(33)23-29-16-19(15-28)30-23)8-7-20(31-22)18-13-26(3,4)34-27(5,6)14-18/h7-9,16,18H,10-14H2,1-6H3,(H,29,30)(H,32,33)
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n/an/a 1.25E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Representative compounds of the present invention were additionally tested in an in vitro assay measuring inhibition of CSF-1 induced monocyte MCP-1 ...


US Patent US10800764 (2020)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


()
BDBM276744
PNG
(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@@H]1CC(C)(C)O[C@@](C)(C1)C(O)=O
PDB
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n/an/a 2.37E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Representative compounds of the present invention were additionally tested in an in vitro assay measuring inhibition of CSF-1 induced monocyte MCP-1 ...


US Patent US10800764 (2020)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


()
BDBM276744
PNG
(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@@H]1CC(C)(C)O[C@@](C)(C1)C(O)=O
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n/an/a 2.93E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Representative compounds of the present invention were additionally tested in an in vitro assay measuring inhibition of CSF-1 induced monocyte MCP-1 ...


US Patent US10800764 (2020)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


()
BDBM276745
PNG
(US10071991, Compound (I-M2-2R,4S) | US10800764, Co...)
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@H]1CC(C)(C)O[C@](C)(C1)C(O)=O
PDB
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n/an/a 8.47E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Representative compounds of the present invention were additionally tested in an in vitro assay measuring inhibition of CSF-1 induced monocyte MCP-1 ...


US Patent US10800764 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%