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Patent code US10800767

Compile Data Set for Download or QSAR
Found 82 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466858
PNG
(US10800767, Example 2)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(cc2Cl)N(C)Cc2noc(=O)[nH]2)nn(C)c1=O
Show InChI InChI=1S/C18H19Cl2N5O4/c1-9(2)11-7-15(22-25(4)17(11)26)28-16-12(19)5-10(6-13(16)20)24(3)8-14-21-18(27)29-23-14/h5-7,9H,8H2,1-4H3,(H,21,23,27)
PDB
MMDB

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US Patent
n/an/an/an/a>5.00E+3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466860
PNG
(US10800767, Example 3-P2)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(N[C@H](C)c3noc(=O)[nH]3)cc2Cl)nn(C)c1=O
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n/an/an/an/a 817n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466861
PNG
(US10800767, Example 14 | US10800767, Example 4)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)nn(C)c1=O
Show InChI InChI=1S/C17H15Cl2N5O5/c1-7(2)9-6-12(22-24(3)16(9)26)28-13-10(18)4-8(5-11(13)19)20-15(25)14-21-17(27)29-23-14/h4-7H,1-3H3,(H,20,25)(H,21,23,27)
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n/an/an/an/a 27.1n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466861
PNG
(US10800767, Example 14 | US10800767, Example 4)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)nn(C)c1=O
Show InChI InChI=1S/C17H15Cl2N5O5/c1-7(2)9-6-12(22-24(3)16(9)26)28-13-10(18)4-8(5-11(13)19)20-15(25)14-21-17(27)29-23-14/h4-7H,1-3H3,(H,20,25)(H,21,23,27)
PDB
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n/an/an/an/a 314n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466876
PNG
(US10800767, Example 20)
Show SMILES CC(C)c1cc(nn(C)c1=O)S(=O)(=O)c1c(Cl)cc(NC(=O)c2noc(=O)[nH]2)cc1Cl
Show InChI InChI=1S/C17H15Cl2N5O6S/c1-7(2)9-6-12(22-24(3)16(9)26)31(28,29)13-10(18)4-8(5-11(13)19)20-15(25)14-21-17(27)30-23-14/h4-7H,1-3H3,(H,20,25)(H,21,23,27)
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n/an/an/an/a>5.00E+3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466877
PNG
(US10800767, Example 21)
Show SMILES Clc1cc(NC(=O)c2noc(=O)[nH]2)cc(Cl)c1Cc1cc(C2CC2)c(=O)[nH]n1
Show InChI InChI=1S/C17H13Cl2N5O4/c18-12-5-8(20-16(26)14-21-17(27)28-24-14)6-13(19)11(12)4-9-3-10(7-1-2-7)15(25)23-22-9/h3,5-7H,1-2,4H2,(H,20,26)(H,23,25)(H,21,24,27)
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n/an/an/an/a>5.00E+3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466869
PNG
(US10800767, Example 13 | US10800767, Example 23)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)n[nH]c1=O
Show InChI InChI=1S/C16H13Cl2N5O5/c1-6(2)8-5-11(21-22-14(8)24)27-12-9(17)3-7(4-10(12)18)19-15(25)13-20-16(26)28-23-13/h3-6H,1-2H3,(H,19,25)(H,22,24)(H,20,23,26)
PDB
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n/an/an/an/a 87.3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466881
PNG
(US10800767, Example 25)
Show SMILES Clc1cc(NC(=O)c2noc(=O)[nH]2)cc(Cl)c1Oc1cc(C2CC2)c(=O)[nH]n1
Show InChI InChI=1S/C16H11Cl2N5O5/c17-9-3-7(19-15(25)13-20-16(26)28-23-13)4-10(18)12(9)27-11-5-8(6-1-2-6)14(24)22-21-11/h3-6H,1-2H2,(H,19,25)(H,22,24)(H,20,23,26)
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n/an/an/an/a 2.42E+3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466882
PNG
(US10800767, Example 26 | US10800767, Example 27)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)c(F)c2Cl)nn(C)c1=O
Show InChI InChI=1S/C17H14Cl2FN5O5/c1-6(2)7-4-10(23-25(3)16(7)27)29-13-8(18)5-9(12(20)11(13)19)21-15(26)14-22-17(28)30-24-14/h4-6H,1-3H3,(H,21,26)(H,22,24,28)
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n/an/an/an/a 26.8n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466884
PNG
(US10800767, Example 28)
Show SMILES CC(C)(C)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)n[nH]c1=O
Show InChI InChI=1S/C17H15Cl2N5O5/c1-17(2,3)8-6-11(22-23-14(8)25)28-12-9(18)4-7(5-10(12)19)20-15(26)13-21-16(27)29-24-13/h4-6H,1-3H3,(H,20,26)(H,23,25)(H,21,24,27)
PDB
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n/an/an/an/a 4.27E+3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466888
PNG
(US10800767, Example 30)
Show SMILES CC(C)c1cc(Oc2c(C)cc(NC(=O)c3noc(=O)[nH]3)cc2C)n[nH]c1=O
Show InChI InChI=1S/C18H19N5O5/c1-8(2)12-7-13(21-22-16(12)24)27-14-9(3)5-11(6-10(14)4)19-17(25)15-20-18(26)28-23-15/h5-8H,1-4H3,(H,19,25)(H,22,24)(H,20,23,26)
PDB
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n/an/an/an/a 3.11E+3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466890
PNG
(N-(3,5-dichloro-4-((5-(1-hydroxypropyl)-6-oxo-1,6-...)
Show SMILES CCC(O)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)n[nH]c1=O
PDB
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n/an/an/an/a 1.55E+3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466897
PNG
(US10800767, Example 37)
Show SMILES Cn1nc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)cc(c1=O)C(C)(C)O
Show InChI InChI=1S/C17H15Cl2N5O6/c1-17(2,28)8-6-11(22-24(3)15(8)26)29-12-9(18)4-7(5-10(12)19)20-14(25)13-21-16(27)30-23-13/h4-6,28H,1-3H3,(H,20,25)(H,21,23,27)
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n/an/an/an/a 212n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466863
PNG
(US10800767, Example 6)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(OCc3noc(=O)[nH]3)cc2Cl)nn(C)c1=O
Show InChI InChI=1S/C17H16Cl2N4O5/c1-8(2)10-6-14(21-23(3)16(10)24)27-15-11(18)4-9(5-12(15)19)26-7-13-20-17(25)28-22-13/h4-6,8H,7H2,1-3H3,(H,20,22,25)
PDB
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n/an/an/an/a 58.1n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466868
PNG
(US10800767, Example 12)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NCc3noc(=O)[nH]3)c(C)c2Cl)nn(C)c1=O
Show InChI InChI=1S/C18H19Cl2N5O4/c1-8(2)10-5-14(23-25(4)17(10)26)28-16-11(19)6-12(9(3)15(16)20)21-7-13-22-18(27)29-24-13/h5-6,8,21H,7H2,1-4H3,(H,22,24,27)
PDB
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n/an/an/an/a 152n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466869
PNG
(US10800767, Example 13 | US10800767, Example 23)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)n[nH]c1=O
Show InChI InChI=1S/C16H13Cl2N5O5/c1-6(2)8-5-11(21-22-14(8)24)27-12-9(17)3-7(4-10(12)18)19-15(25)13-20-16(26)28-23-13/h3-6H,1-2H3,(H,19,25)(H,22,24)(H,20,23,26)
PDB
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n/an/an/an/a 1.63E+3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466861
PNG
(US10800767, Example 14 | US10800767, Example 4)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)nn(C)c1=O
Show InChI InChI=1S/C17H15Cl2N5O5/c1-7(2)9-6-12(22-24(3)16(9)26)28-13-10(18)4-8(5-11(13)19)20-15(25)14-21-17(27)29-23-14/h4-7H,1-3H3,(H,20,25)(H,21,23,27)
PDB
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n/an/an/an/a 549n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466857
PNG
(US10800767, Example 1 | US10800767, Example 16)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NCc3noc(=O)[nH]3)cc2Cl)nn(C)c1=O
Show InChI InChI=1S/C17H17Cl2N5O4/c1-8(2)10-6-14(22-24(3)16(10)25)27-15-11(18)4-9(5-12(15)19)20-7-13-21-17(26)28-23-13/h4-6,8,20H,7H2,1-3H3,(H,21,23,26)
PDB
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n/an/an/an/a 44.2n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466875
PNG
(US10800767, Example 19)
Show SMILES CC(C)c1cc(nn(C)c1=O)S(=O)(=O)c1c(Cl)cc(NCc2noc(=O)[nH]2)cc1Cl
Show InChI InChI=1S/C17H17Cl2N5O5S/c1-8(2)10-6-14(22-24(3)16(10)25)30(27,28)15-11(18)4-9(5-12(15)19)20-7-13-21-17(26)29-23-13/h4-6,8,20H,7H2,1-3H3,(H,21,23,26)
PDB
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n/an/an/an/a>5.00E+3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466875
PNG
(US10800767, Example 19)
Show SMILES CC(C)c1cc(nn(C)c1=O)S(=O)(=O)c1c(Cl)cc(NCc2noc(=O)[nH]2)cc1Cl
Show InChI InChI=1S/C17H17Cl2N5O5S/c1-8(2)10-6-14(22-24(3)16(10)25)30(27,28)15-11(18)4-9(5-12(15)19)20-7-13-21-17(26)29-23-13/h4-6,8,20H,7H2,1-3H3,(H,21,23,26)
PDB
MMDB

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US Patent
n/an/an/an/a 1.93E+3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466882
PNG
(US10800767, Example 26 | US10800767, Example 27)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)c(F)c2Cl)nn(C)c1=O
Show InChI InChI=1S/C17H14Cl2FN5O5/c1-6(2)7-4-10(23-25(3)16(7)27)29-13-8(18)5-9(12(20)11(13)19)21-15(26)14-22-17(28)30-24-14/h4-6H,1-3H3,(H,21,26)(H,22,24,28)
PDB
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n/an/an/an/a 144n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466889
PNG
(US10800767, Example 31)
Show SMILES Clc1cc(NC(=O)c2noc(=O)[nH]2)cc(Cl)c1Oc1cc(c(=O)[nH]n1)C12CC(C1)C2
Show InChI InChI=1S/C18H13Cl2N5O5/c19-10-1-8(21-16(27)14-22-17(28)30-25-14)2-11(20)13(10)29-12-3-9(15(26)24-23-12)18-4-7(5-18)6-18/h1-3,7H,4-6H2,(H,21,27)(H,24,26)(H,22,25,28)
PDB
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n/an/an/an/a 600n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466889
PNG
(US10800767, Example 31)
Show SMILES Clc1cc(NC(=O)c2noc(=O)[nH]2)cc(Cl)c1Oc1cc(c(=O)[nH]n1)C12CC(C1)C2
Show InChI InChI=1S/C18H13Cl2N5O5/c19-10-1-8(21-16(27)14-22-17(28)30-25-14)2-11(20)13(10)29-12-3-9(15(26)24-23-12)18-4-7(5-18)6-18/h1-3,7H,4-6H2,(H,21,27)(H,24,26)(H,22,25,28)
PDB
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n/an/an/an/a>5.00E+3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466892
PNG
(US10800767, Example 32P2)
Show SMILES CC[C@H](O)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)n[nH]c1=O
PDB
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n/an/an/an/a 43.3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466892
PNG
(US10800767, Example 32P2)
Show SMILES CC[C@H](O)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)n[nH]c1=O
PDB
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n/an/an/an/a 1.15E+3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466895
PNG
(US10800767, Example 35)
Show SMILES CC(CO)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)nn(C)c1=O
PDB
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n/an/an/an/a 762n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466859
PNG
(US10800767, Example 3-P1)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(N[C@@H](C)c3noc(=O)[nH]3)cc2Cl)nn(C)c1=O
PDB
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n/an/an/an/a 277n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466867
PNG
(US10800767, Example 11)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)c(C)c2Cl)nn(C)c1=O
Show InChI InChI=1S/C18H17Cl2N5O5/c1-7(2)9-5-12(23-25(4)17(9)27)29-14-10(19)6-11(8(3)13(14)20)21-16(26)15-22-18(28)30-24-15/h5-7H,1-4H3,(H,21,26)(H,22,24,28)
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n/an/an/an/a 192n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466868
PNG
(US10800767, Example 12)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NCc3noc(=O)[nH]3)c(C)c2Cl)nn(C)c1=O
Show InChI InChI=1S/C18H19Cl2N5O4/c1-8(2)10-5-14(23-25(4)17(10)26)28-16-11(19)6-12(9(3)15(16)20)21-7-13-22-18(27)29-24-13/h5-6,8,21H,7H2,1-4H3,(H,22,24,27)
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n/an/an/an/a 71.2n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466862
PNG
(US10800767, Example 15 | US10800767, Example 5)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NCc3noc(=O)[nH]3)cc2Cl)n[nH]c1=O
Show InChI InChI=1S/C16H15Cl2N5O4/c1-7(2)9-5-13(21-22-15(9)24)26-14-10(17)3-8(4-11(14)18)19-6-12-20-16(25)27-23-12/h3-5,7,19H,6H2,1-2H3,(H,22,24)(H,20,23,25)
PDB
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n/an/an/an/a 31.5n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466857
PNG
(US10800767, Example 1 | US10800767, Example 16)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NCc3noc(=O)[nH]3)cc2Cl)nn(C)c1=O
Show InChI InChI=1S/C17H17Cl2N5O4/c1-8(2)10-6-14(22-24(3)16(10)25)27-15-11(18)4-9(5-12(15)19)20-7-13-21-17(26)28-23-13/h4-6,8,20H,7H2,1-3H3,(H,21,23,26)
PDB
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n/an/an/an/a 82.4n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466882
PNG
(US10800767, Example 26 | US10800767, Example 27)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)c(F)c2Cl)nn(C)c1=O
Show InChI InChI=1S/C17H14Cl2FN5O5/c1-6(2)7-4-10(23-25(3)16(7)27)29-13-8(18)5-9(12(20)11(13)19)21-15(26)14-22-17(28)30-24-14/h4-6H,1-3H3,(H,21,26)(H,22,24,28)
PDB
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n/an/an/an/a 58.1n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466886
PNG
(US10800767, Example 29P1)
Show SMILES C[C@@H](O)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)n[nH]c1=O
PDB
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n/an/an/an/a>5.00E+3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466893
PNG
(US10800767, Example 33)
Show SMILES CC(C)(O)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)n[nH]c1=O
Show InChI InChI=1S/C16H13Cl2N5O6/c1-16(2,27)7-5-10(21-22-13(7)24)28-11-8(17)3-6(4-9(11)18)19-14(25)12-20-15(26)29-23-12/h3-5,27H,1-2H3,(H,19,25)(H,22,24)(H,20,23,26)
PDB
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n/an/an/an/a>5.00E+3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466895
PNG
(US10800767, Example 35)
Show SMILES CC(CO)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)nn(C)c1=O
PDB
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n/an/an/an/a 2.60E+3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466857
PNG
(US10800767, Example 1 | US10800767, Example 16)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NCc3noc(=O)[nH]3)cc2Cl)nn(C)c1=O
Show InChI InChI=1S/C17H17Cl2N5O4/c1-8(2)10-6-14(22-24(3)16(10)25)27-15-11(18)4-9(5-12(15)19)20-7-13-21-17(26)28-23-13/h4-6,8,20H,7H2,1-3H3,(H,21,23,26)
PDB
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n/an/an/an/a 7.60n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466857
PNG
(US10800767, Example 1 | US10800767, Example 16)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NCc3noc(=O)[nH]3)cc2Cl)nn(C)c1=O
Show InChI InChI=1S/C17H17Cl2N5O4/c1-8(2)10-6-14(22-24(3)16(10)25)27-15-11(18)4-9(5-12(15)19)20-7-13-21-17(26)28-23-13/h4-6,8,20H,7H2,1-3H3,(H,21,23,26)
PDB
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n/an/an/an/a 49.5n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466860
PNG
(US10800767, Example 3-P2)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(N[C@H](C)c3noc(=O)[nH]3)cc2Cl)nn(C)c1=O
PDB
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n/an/an/an/a 732n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466873
PNG
(US10800767, Example 17)
Show SMILES CC(C)c1cc(nn(C)c1=O)C(=O)c1c(Cl)cc(NC(=O)c2noc(=O)[nH]2)cc1Cl
Show InChI InChI=1S/C18H15Cl2N5O5/c1-7(2)9-6-12(23-25(3)17(9)28)14(26)13-10(19)4-8(5-11(13)20)21-16(27)15-22-18(29)30-24-15/h4-7H,1-3H3,(H,21,27)(H,22,24,29)
PDB
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n/an/an/an/a 2.11E+3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466876
PNG
(US10800767, Example 20)
Show SMILES CC(C)c1cc(nn(C)c1=O)S(=O)(=O)c1c(Cl)cc(NC(=O)c2noc(=O)[nH]2)cc1Cl
Show InChI InChI=1S/C17H15Cl2N5O6S/c1-7(2)9-6-12(22-24(3)16(9)26)31(28,29)13-10(18)4-8(5-11(13)19)20-15(25)14-21-17(27)30-23-14/h4-7H,1-3H3,(H,20,25)(H,21,23,27)
PDB
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n/an/an/an/a>5.00E+3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466882
PNG
(US10800767, Example 26 | US10800767, Example 27)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)c(F)c2Cl)nn(C)c1=O
Show InChI InChI=1S/C17H14Cl2FN5O5/c1-6(2)7-4-10(23-25(3)16(7)27)29-13-8(18)5-9(12(20)11(13)19)21-15(26)14-22-17(28)30-24-14/h4-6H,1-3H3,(H,21,26)(H,22,24,28)
PDB
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n/an/an/an/a 699n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466858
PNG
(US10800767, Example 2)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(cc2Cl)N(C)Cc2noc(=O)[nH]2)nn(C)c1=O
Show InChI InChI=1S/C18H19Cl2N5O4/c1-9(2)11-7-15(22-25(4)17(11)26)28-16-12(19)5-10(6-13(16)20)24(3)8-14-21-18(27)29-23-14/h5-7,9H,8H2,1-4H3,(H,21,23,27)
PDB
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n/an/an/an/a>5.00E+3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466863
PNG
(US10800767, Example 6)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(OCc3noc(=O)[nH]3)cc2Cl)nn(C)c1=O
Show InChI InChI=1S/C17H16Cl2N4O5/c1-8(2)10-6-14(21-23(3)16(10)24)27-15-11(18)4-9(5-12(15)19)26-7-13-20-17(25)28-22-13/h4-6,8H,7H2,1-3H3,(H,20,22,25)
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n/an/an/an/a 78n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466865
PNG
(US10800767, Example 8)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(cc2Cl)-c2cc(=O)[nH]o2)n[nH]c1=O
Show InChI InChI=1S/C16H13Cl2N3O4/c1-7(2)9-5-14(19-20-16(9)23)24-15-10(17)3-8(4-11(15)18)12-6-13(22)21-25-12/h3-7H,1-2H3,(H,20,23)(H,21,22)
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n/an/an/an/a 896n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466874
PNG
(US10800767, Example 18)
Show SMILES CC(C)c1cc(nn(C)c1=O)C(=O)c1c(Cl)cc(NCc2noc(=O)[nH]2)cc1Cl
Show InChI InChI=1S/C18H17Cl2N5O4/c1-8(2)10-6-13(23-25(3)17(10)27)16(26)15-11(19)4-9(5-12(15)20)21-7-14-22-18(28)29-24-14/h4-6,8,21H,7H2,1-3H3,(H,22,24,28)
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n/an/an/an/a 271n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466878
PNG
(US10800767, Example 22)
Show SMILES Cn1nc(Cc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)cc(C2CC2)c1=O
Show InChI InChI=1S/C18H15Cl2N5O4/c1-25-17(27)11(8-2-3-8)4-10(23-25)5-12-13(19)6-9(7-14(12)20)21-16(26)15-22-18(28)29-24-15/h4,6-8H,2-3,5H2,1H3,(H,21,26)(H,22,24,28)
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n/an/an/an/a 181n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466880
PNG
(US10800767, Example 24)
Show SMILES CC(C)c1cc(Oc2c3CCCc3c(NC(=O)c3noc(=O)[nH]3)cc2Cl)nn(C)c1=O
Show InChI InChI=1S/C20H20ClN5O5/c1-9(2)12-7-15(24-26(3)19(12)28)30-16-11-6-4-5-10(11)14(8-13(16)21)22-18(27)17-23-20(29)31-25-17/h7-9H,4-6H2,1-3H3,(H,22,27)(H,23,25,29)
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n/an/an/an/a 188n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466880
PNG
(US10800767, Example 24)
Show SMILES CC(C)c1cc(Oc2c3CCCc3c(NC(=O)c3noc(=O)[nH]3)cc2Cl)nn(C)c1=O
Show InChI InChI=1S/C20H20ClN5O5/c1-9(2)12-7-15(24-26(3)19(12)28)30-16-11-6-4-5-10(11)14(8-13(16)21)22-18(27)17-23-20(29)31-25-17/h7-9H,4-6H2,1-3H3,(H,22,27)(H,23,25,29)
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n/an/an/an/a 2.05E+3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466881
PNG
(US10800767, Example 25)
Show SMILES Clc1cc(NC(=O)c2noc(=O)[nH]2)cc(Cl)c1Oc1cc(C2CC2)c(=O)[nH]n1
Show InChI InChI=1S/C16H11Cl2N5O5/c17-9-3-7(19-15(25)13-20-16(26)28-23-13)4-10(18)12(9)27-11-5-8(6-1-2-6)14(24)22-21-11/h3-6H,1-2H2,(H,19,25)(H,22,24)(H,20,23,26)
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n/an/an/an/a 231n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466885
PNG
((P1 and P2): N-(3,5-dichloro-4-((5-(1-hydroxyethyl...)
Show SMILES CC(O)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)n[nH]c1=O
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n/an/an/an/a 4.34E+3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466891
PNG
(US10800767, Example 32P1)
Show SMILES CC[C@@H](O)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)n[nH]c1=O
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n/an/an/an/a 4.23E+3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466896
PNG
(US10800767, Example 36)
Show SMILES CC(CO)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)n[nH]c1=O
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n/an/an/an/a 468n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466862
PNG
(US10800767, Example 15 | US10800767, Example 5)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NCc3noc(=O)[nH]3)cc2Cl)n[nH]c1=O
Show InChI InChI=1S/C16H15Cl2N5O4/c1-7(2)9-5-13(21-22-15(9)24)26-14-10(17)3-8(4-11(14)18)19-6-12-20-16(25)27-23-12/h3-5,7,19H,6H2,1-2H3,(H,22,24)(H,20,23,25)
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n/an/an/an/a 74.2n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466873
PNG
(US10800767, Example 17)
Show SMILES CC(C)c1cc(nn(C)c1=O)C(=O)c1c(Cl)cc(NC(=O)c2noc(=O)[nH]2)cc1Cl
Show InChI InChI=1S/C18H15Cl2N5O5/c1-7(2)9-6-12(23-25(3)17(9)28)14(26)13-10(19)4-8(5-11(13)20)21-16(27)15-22-18(29)30-24-15/h4-7H,1-3H3,(H,21,27)(H,22,24,29)
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n/an/an/an/a>5.00E+3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466874
PNG
(US10800767, Example 18)
Show SMILES CC(C)c1cc(nn(C)c1=O)C(=O)c1c(Cl)cc(NCc2noc(=O)[nH]2)cc1Cl
Show InChI InChI=1S/C18H17Cl2N5O4/c1-8(2)10-6-13(23-25(3)17(10)27)16(26)15-11(19)4-9(5-12(15)20)21-7-14-22-18(28)29-24-14/h4-6,8,21H,7H2,1-3H3,(H,22,24,28)
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n/an/an/an/a 550n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466897
PNG
(US10800767, Example 37)
Show SMILES Cn1nc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)cc(c1=O)C(C)(C)O
Show InChI InChI=1S/C17H15Cl2N5O6/c1-17(2,28)8-6-11(22-24(3)15(8)26)29-12-9(18)4-7(5-10(12)19)20-14(25)13-21-16(27)30-23-13/h4-6,28H,1-3H3,(H,20,25)(H,21,23,27)
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n/an/an/an/a 34.5n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466859
PNG
(US10800767, Example 3-P1)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(N[C@@H](C)c3noc(=O)[nH]3)cc2Cl)nn(C)c1=O
PDB
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n/an/an/an/a 75.9n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466864
PNG
(US10800767, Example 7)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(cc2Cl)-c2cc(=O)[nH]o2)nn(C)c1=O
Show InChI InChI=1S/C17H15Cl2N3O4/c1-8(2)10-6-15(20-22(3)17(10)24)25-16-11(18)4-9(5-12(16)19)13-7-14(23)21-26-13/h4-8H,1-3H3,(H,21,23)
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n/an/an/an/a 60.9n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466865
PNG
(US10800767, Example 8)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(cc2Cl)-c2cc(=O)[nH]o2)n[nH]c1=O
Show InChI InChI=1S/C16H13Cl2N3O4/c1-7(2)9-5-14(19-20-16(9)23)24-15-10(17)3-8(4-11(15)18)12-6-13(22)21-25-12/h3-7H,1-2H3,(H,20,23)(H,21,22)
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n/an/an/an/a 2.30E+3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466866
PNG
(US10800767, Example 9)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(cc2Cl)-c2noc(=O)[nH]2)n[nH]c1=O
Show InChI InChI=1S/C15H12Cl2N4O4/c1-6(2)8-5-11(19-20-14(8)22)24-12-9(16)3-7(4-10(12)17)13-18-15(23)25-21-13/h3-6H,1-2H3,(H,20,22)(H,18,21,23)
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n/an/an/an/a 290n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466861
PNG
(US10800767, Example 14 | US10800767, Example 4)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)nn(C)c1=O
Show InChI InChI=1S/C17H15Cl2N5O5/c1-7(2)9-6-12(22-24(3)16(9)26)28-13-10(18)4-8(5-11(13)19)20-15(25)14-21-17(27)29-23-14/h4-7H,1-3H3,(H,20,25)(H,21,23,27)
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n/an/an/an/a 46.6n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466877
PNG
(US10800767, Example 21)
Show SMILES Clc1cc(NC(=O)c2noc(=O)[nH]2)cc(Cl)c1Cc1cc(C2CC2)c(=O)[nH]n1
Show InChI InChI=1S/C17H13Cl2N5O4/c18-12-5-8(20-16(26)14-21-17(27)28-24-14)6-13(19)11(12)4-9-3-10(7-1-2-7)15(25)23-22-9/h3,5-7H,1-2,4H2,(H,20,26)(H,23,25)(H,21,24,27)
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n/an/an/an/a 180n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466869
PNG
(US10800767, Example 13 | US10800767, Example 23)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)n[nH]c1=O
Show InChI InChI=1S/C16H13Cl2N5O5/c1-6(2)8-5-11(21-22-14(8)24)27-12-9(17)3-7(4-10(12)18)19-15(25)13-20-16(26)28-23-13/h3-6H,1-2H3,(H,19,25)(H,22,24)(H,20,23,26)
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n/an/an/an/a 1.32E+3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466884
PNG
(US10800767, Example 28)
Show SMILES CC(C)(C)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)n[nH]c1=O
Show InChI InChI=1S/C17H15Cl2N5O5/c1-17(2,3)8-6-11(22-23-14(8)25)28-12-9(18)4-7(5-10(12)19)20-15(26)13-21-16(27)29-24-13/h4-6H,1-3H3,(H,20,26)(H,23,25)(H,21,24,27)
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n/an/an/an/a 286n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466888
PNG
(US10800767, Example 30)
Show SMILES CC(C)c1cc(Oc2c(C)cc(NC(=O)c3noc(=O)[nH]3)cc2C)n[nH]c1=O
Show InChI InChI=1S/C18H19N5O5/c1-8(2)12-7-13(21-22-16(12)24)27-14-9(3)5-11(6-10(14)4)19-17(25)15-20-18(26)28-23-15/h5-8H,1-4H3,(H,19,25)(H,22,24)(H,20,23,26)
PDB
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n/an/an/an/a 821n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466891
PNG
(US10800767, Example 32P1)
Show SMILES CC[C@@H](O)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)n[nH]c1=O
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n/an/an/an/a 450n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466894
PNG
(US10800767, Example 34)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)c(F)c2Cl)n[nH]c1=O
Show InChI InChI=1S/C16H12Cl2FN5O5/c1-5(2)6-3-9(22-23-14(6)25)28-12-7(17)4-8(11(19)10(12)18)20-15(26)13-21-16(27)29-24-13/h3-5H,1-2H3,(H,20,26)(H,23,25)(H,21,24,27)
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n/an/an/an/a 166n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466862
PNG
(US10800767, Example 15 | US10800767, Example 5)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NCc3noc(=O)[nH]3)cc2Cl)n[nH]c1=O
Show InChI InChI=1S/C16H15Cl2N5O4/c1-7(2)9-5-13(21-22-15(9)24)26-14-10(17)3-8(4-11(14)18)19-6-12-20-16(25)27-23-12/h3-5,7,19H,6H2,1-2H3,(H,22,24)(H,20,23,25)
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n/an/an/an/a 469n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466864
PNG
(US10800767, Example 7)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(cc2Cl)-c2cc(=O)[nH]o2)nn(C)c1=O
Show InChI InChI=1S/C17H15Cl2N3O4/c1-8(2)10-6-15(20-22(3)17(10)24)25-16-11(18)4-9(5-12(16)19)13-7-14(23)21-26-13/h4-8H,1-3H3,(H,21,23)
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n/an/an/an/a 473n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466866
PNG
(US10800767, Example 9)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(cc2Cl)-c2noc(=O)[nH]2)n[nH]c1=O
Show InChI InChI=1S/C15H12Cl2N4O4/c1-6(2)8-5-11(19-20-14(8)22)24-12-9(16)3-7(4-10(12)17)13-18-15(23)25-21-13/h3-6H,1-2H3,(H,20,22)(H,18,21,23)
PDB
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n/an/an/an/a 126n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466867
PNG
(US10800767, Example 11)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)c(C)c2Cl)nn(C)c1=O
Show InChI InChI=1S/C18H17Cl2N5O5/c1-7(2)9-5-12(23-25(4)17(9)27)29-14-10(19)6-11(8(3)13(14)20)21-16(26)15-22-18(28)30-24-15/h5-7H,1-4H3,(H,21,26)(H,22,24,28)
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n/an/an/an/a 116n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466869
PNG
(US10800767, Example 13 | US10800767, Example 23)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)n[nH]c1=O
Show InChI InChI=1S/C16H13Cl2N5O5/c1-6(2)8-5-11(21-22-14(8)24)27-12-9(17)3-7(4-10(12)18)19-15(25)13-20-16(26)28-23-13/h3-6H,1-2H3,(H,19,25)(H,22,24)(H,20,23,26)
PDB
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n/an/an/an/a 53.6n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466862
PNG
(US10800767, Example 15 | US10800767, Example 5)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NCc3noc(=O)[nH]3)cc2Cl)n[nH]c1=O
Show InChI InChI=1S/C16H15Cl2N5O4/c1-7(2)9-5-13(21-22-15(9)24)26-14-10(17)3-8(4-11(14)18)19-6-12-20-16(25)27-23-12/h3-5,7,19H,6H2,1-2H3,(H,22,24)(H,20,23,25)
PDB
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n/an/an/an/a 102n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466878
PNG
(US10800767, Example 22)
Show SMILES Cn1nc(Cc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)cc(C2CC2)c1=O
Show InChI InChI=1S/C18H15Cl2N5O4/c1-25-17(27)11(8-2-3-8)4-10(23-25)5-12-13(19)6-9(7-14(12)20)21-16(26)15-22-18(28)29-24-15/h4,6-8H,2-3,5H2,1H3,(H,21,26)(H,22,24,28)
PDB
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n/an/an/an/a 898n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466885
PNG
((P1 and P2): N-(3,5-dichloro-4-((5-(1-hydroxyethyl...)
Show SMILES CC(O)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)n[nH]c1=O
PDB
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n/an/an/an/a 235n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466886
PNG
(US10800767, Example 29P1)
Show SMILES C[C@@H](O)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)n[nH]c1=O
PDB
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n/an/an/an/a 2.64E+3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466887
PNG
(US10800767, Example 29P2)
Show SMILES C[C@H](O)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)n[nH]c1=O
PDB
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n/an/an/an/a 91.3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466887
PNG
(US10800767, Example 29P2)
Show SMILES C[C@H](O)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)n[nH]c1=O
PDB
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n/an/an/an/a 1.76E+3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466890
PNG
(N-(3,5-dichloro-4-((5-(1-hydroxypropyl)-6-oxo-1,6-...)
Show SMILES CCC(O)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)n[nH]c1=O
PDB
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n/an/an/an/a 86.4n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor beta


(Homo sapiens (Human))
BDBM466893
PNG
(US10800767, Example 33)
Show SMILES CC(C)(O)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)n[nH]c1=O
Show InChI InChI=1S/C16H13Cl2N5O6/c1-16(2,27)7-5-10(21-22-13(7)24)28-11-8(17)3-6(4-9(11)18)19-14(25)12-20-15(26)29-23-12/h3-5,27H,1-2H3,(H,19,25)(H,22,24)(H,20,23,26)
PDB
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n/an/an/an/a 212n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466894
PNG
(US10800767, Example 34)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)c(F)c2Cl)n[nH]c1=O
Show InChI InChI=1S/C16H12Cl2FN5O5/c1-5(2)6-3-9(22-23-14(6)25)28-12-7(17)4-8(11(19)10(12)18)20-15(26)13-21-16(27)29-24-13/h3-5H,1-2H3,(H,20,26)(H,23,25)(H,21,24,27)
PDB
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n/an/an/an/a 577n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
Thyroid hormone receptor alpha


(Homo sapiens (Human))
BDBM466896
PNG
(US10800767, Example 36)
Show SMILES CC(CO)c1cc(Oc2c(Cl)cc(NC(=O)c3noc(=O)[nH]3)cc2Cl)n[nH]c1=O
PDB
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n/an/an/an/a>5.00E+3n/an/an/an/a



Terns, Inc.

US Patent


Assay Description
LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen™ TR-FRET Thyroid Receptor beta Coactivator Assay ki...


US Patent US10800767 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%