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Patent code US10807944

Compile Data Set for Download or QSAR
Found 144 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468611
PNG
(US10807944, Compound SR-4370)
Show SMILES CCCCNNC(=O)c1ccc(cc1)-c1cccc(F)c1F
Show InChI InChI=1S/C17H18F2N2O/c1-2-3-11-20-21-17(22)13-9-7-12(8-10-13)14-5-4-6-15(18)16(14)19/h4-10,20H,2-3,11H2,1H3,(H,21,22)
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US Patent
n/an/a 6n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM468602
PNG
(US10807944, Compound RLS2-312)
Show SMILES CCCCNNC(=O)c1ccc(CN=[N+]=[N-])cc1
Show InChI InChI=1S/C12H17N5O/c1-2-3-8-14-16-12(18)11-6-4-10(5-7-11)9-15-17-13/h4-7,14H,2-3,8-9H2,1H3,(H,16,18)
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n/an/a 9n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM163626
PNG
(SR-3302 | US10807944, Compound RLS2-211)
Show SMILES CCCCNNC(=O)c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C15H24N2O/c1-5-6-11-16-17-14(18)12-7-9-13(10-8-12)15(2,3)4/h7-10,16H,5-6,11H2,1-4H3,(H,17,18)
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n/an/a 45n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM163626
PNG
(SR-3302 | US10807944, Compound RLS2-211)
Show SMILES CCCCNNC(=O)c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C15H24N2O/c1-5-6-11-16-17-14(18)12-7-9-13(10-8-12)15(2,3)4/h7-10,16H,5-6,11H2,1-4H3,(H,17,18)
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n/an/a 45n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM163619
PNG
(UF010 | US10807944, Compound UF010)
Show SMILES CCCCNNC(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C11H15BrN2O/c1-2-3-8-13-14-11(15)9-4-6-10(12)7-5-9/h4-7,13H,2-3,8H2,1H3,(H,14,15)
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n/an/a 60n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468609
PNG
(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Show SMILES CCCCNNC(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C17H20N2O/c1-2-3-13-18-19-17(20)16-11-9-15(10-12-16)14-7-5-4-6-8-14/h4-12,18H,2-3,13H2,1H3,(H,19,20)
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n/an/a 60n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM163626
PNG
(SR-3302 | US10807944, Compound RLS2-211)
Show SMILES CCCCNNC(=O)c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C15H24N2O/c1-5-6-11-16-17-14(18)12-7-9-13(10-8-12)15(2,3)4/h7-10,16H,5-6,11H2,1-4H3,(H,17,18)
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n/an/a 70n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM468609
PNG
(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Show SMILES CCCCNNC(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C17H20N2O/c1-2-3-13-18-19-17(20)16-11-9-15(10-12-16)14-7-5-4-6-8-14/h4-12,18H,2-3,13H2,1H3,(H,19,20)
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n/an/a 90n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM163619
PNG
(UF010 | US10807944, Compound UF010)
Show SMILES CCCCNNC(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C11H15BrN2O/c1-2-3-8-13-14-11(15)9-4-6-10(12)7-5-9/h4-7,13H,2-3,8H2,1H3,(H,14,15)
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n/an/a 100n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM163624
PNG
(SR-3208 | US10807944, Compound RLS2-131)
Show SMILES CCCCNNC(=O)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C13H21N3O/c1-4-5-10-14-15-13(17)11-6-8-12(9-7-11)16(2)3/h6-9,14H,4-5,10H2,1-3H3,(H,15,17)
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n/an/a 120n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM468611
PNG
(US10807944, Compound SR-4370)
Show SMILES CCCCNNC(=O)c1ccc(cc1)-c1cccc(F)c1F
Show InChI InChI=1S/C17H18F2N2O/c1-2-3-11-20-21-17(22)13-9-7-12(8-10-13)14-5-4-6-15(18)16(14)19/h4-10,20H,2-3,11H2,1H3,(H,21,22)
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n/an/a 130n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468602
PNG
(US10807944, Compound RLS2-312)
Show SMILES CCCCNNC(=O)c1ccc(CN=[N+]=[N-])cc1
Show InChI InChI=1S/C12H17N5O/c1-2-3-8-14-16-12(18)11-6-4-10(5-7-11)9-15-17-13/h4-7,14H,2-3,8-9H2,1H3,(H,16,18)
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n/an/a 150n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM163626
PNG
(SR-3302 | US10807944, Compound RLS2-211)
Show SMILES CCCCNNC(=O)c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C15H24N2O/c1-5-6-11-16-17-14(18)12-7-9-13(10-8-12)15(2,3)4/h7-10,16H,5-6,11H2,1-4H3,(H,17,18)
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n/an/a 190n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM163628
PNG
(SR-3212 | US10807944, Compound RLS2-137)
Show SMILES CCCNNC(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C10H13BrN2O/c1-2-7-12-13-10(14)8-3-5-9(11)6-4-8/h3-6,12H,2,7H2,1H3,(H,13,14)
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n/an/a 220n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM163624
PNG
(SR-3208 | US10807944, Compound RLS2-131)
Show SMILES CCCCNNC(=O)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C13H21N3O/c1-4-5-10-14-15-13(17)11-6-8-12(9-7-11)16(2)3/h6-9,14H,4-5,10H2,1-3H3,(H,15,17)
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n/an/a 230n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM468602
PNG
(US10807944, Compound RLS2-312)
Show SMILES CCCCNNC(=O)c1ccc(CN=[N+]=[N-])cc1
Show InChI InChI=1S/C12H17N5O/c1-2-3-8-14-16-12(18)11-6-4-10(5-7-11)9-15-17-13/h4-7,14H,2-3,8-9H2,1H3,(H,16,18)
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n/an/a 320n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468612
PNG
(US10807944, Compound SR-4372)
Show SMILES CCCCNNC(=O)c1ccc(cc1)-c1cc(C)cc(F)c1
Show InChI InChI=1S/C18H21FN2O/c1-3-4-9-20-21-18(22)15-7-5-14(6-8-15)16-10-13(2)11-17(19)12-16/h5-8,10-12,20H,3-4,9H2,1-2H3,(H,21,22)
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n/an/a 380n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468613
PNG
(US10807944, Compound SR-4373)
Show SMILES CCCCNNC(=O)c1ccc(cc1)-c1cc(ccc1F)C(=O)OCC
Show InChI InChI=1S/C20H23FN2O3/c1-3-5-12-22-23-19(24)15-8-6-14(7-9-15)17-13-16(10-11-18(17)21)20(25)26-4-2/h6-11,13,22H,3-5,12H2,1-2H3,(H,23,24)
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n/an/a 420n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM163623
PNG
(SR-3206 | US10807944, Compound RLS2-126 | US108706...)
Show SMILES CCCCNNC(=O)c1ccc(OC)cc1
Show InChI InChI=1S/C12H18N2O2/c1-3-4-9-13-14-12(15)10-5-7-11(16-2)8-6-10/h5-8,13H,3-4,9H2,1-2H3,(H,14,15)
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n/an/a 430n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM163619
PNG
(UF010 | US10807944, Compound UF010)
Show SMILES CCCCNNC(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C11H15BrN2O/c1-2-3-8-13-14-11(15)9-4-6-10(12)7-5-9/h4-7,13H,2-3,8H2,1H3,(H,14,15)
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n/an/a 500n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM468602
PNG
(US10807944, Compound RLS2-312)
Show SMILES CCCCNNC(=O)c1ccc(CN=[N+]=[N-])cc1
Show InChI InChI=1S/C12H17N5O/c1-2-3-8-14-16-12(18)11-6-4-10(5-7-11)9-15-17-13/h4-7,14H,2-3,8-9H2,1H3,(H,16,18)
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n/an/a 527n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM468611
PNG
(US10807944, Compound SR-4370)
Show SMILES CCCCNNC(=O)c1ccc(cc1)-c1cccc(F)c1F
Show InChI InChI=1S/C17H18F2N2O/c1-2-3-11-20-21-17(22)13-9-7-12(8-10-13)14-5-4-6-15(18)16(14)19/h4-10,20H,2-3,11H2,1H3,(H,21,22)
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n/an/a 580n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM468612
PNG
(US10807944, Compound SR-4372)
Show SMILES CCCCNNC(=O)c1ccc(cc1)-c1cc(C)cc(F)c1
Show InChI InChI=1S/C18H21FN2O/c1-3-4-9-20-21-18(22)15-7-5-14(6-8-15)16-10-13(2)11-17(19)12-16/h5-8,10-12,20H,3-4,9H2,1-2H3,(H,21,22)
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US Patent
n/an/a 760n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM468609
PNG
(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Show SMILES CCCCNNC(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C17H20N2O/c1-2-3-13-18-19-17(20)16-11-9-15(10-12-16)14-7-5-4-6-8-14/h4-12,18H,2-3,13H2,1H3,(H,19,20)
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US Patent
n/an/a 800n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468608
PNG
(US10807944, Compound RLS3-14)
Show SMILES CCCCNNC(=O)c1ccc(OCC)c(OCC)c1
Show InChI InChI=1S/C15H24N2O3/c1-4-7-10-16-17-15(18)12-8-9-13(19-5-2)14(11-12)20-6-3/h8-9,11,16H,4-7,10H2,1-3H3,(H,17,18)
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US Patent
n/an/a 800n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM163624
PNG
(SR-3208 | US10807944, Compound RLS2-131)
Show SMILES CCCCNNC(=O)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C13H21N3O/c1-4-5-10-14-15-13(17)11-6-8-12(9-7-11)16(2)3/h6-9,14H,4-5,10H2,1-3H3,(H,15,17)
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US Patent
n/an/a 880n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM468602
PNG
(US10807944, Compound RLS2-312)
Show SMILES CCCCNNC(=O)c1ccc(CN=[N+]=[N-])cc1
Show InChI InChI=1S/C12H17N5O/c1-2-3-8-14-16-12(18)11-6-4-10(5-7-11)9-15-17-13/h4-7,14H,2-3,8-9H2,1H3,(H,16,18)
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US Patent
n/an/a 886n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM163625
PNG
(SR-3210 | US10807944, Compound RLS2-133)
Show SMILES CCCCNNC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C11H15ClN2O/c1-2-3-8-13-14-11(15)9-4-6-10(12)7-5-9/h4-7,13H,2-3,8H2,1H3,(H,14,15)
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US Patent
n/an/a 950n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM163626
PNG
(SR-3302 | US10807944, Compound RLS2-211)
Show SMILES CCCCNNC(=O)c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C15H24N2O/c1-5-6-11-16-17-14(18)12-7-9-13(10-8-12)15(2,3)4/h7-10,16H,5-6,11H2,1-4H3,(H,17,18)
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US Patent
n/an/a 1.04E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM163632
PNG
(SR-3297 | US10807944, Compound RLS2-219)
Show SMILES Brc1ccc(cc1)C(=O)NNCCC1CCCC1
Show InChI InChI=1S/C14H19BrN2O/c15-13-7-5-12(6-8-13)14(18)17-16-10-9-11-3-1-2-4-11/h5-8,11,16H,1-4,9-10H2,(H,17,18)
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US Patent
n/an/a 1.08E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM468612
PNG
(US10807944, Compound SR-4372)
Show SMILES CCCCNNC(=O)c1ccc(cc1)-c1cc(C)cc(F)c1
Show InChI InChI=1S/C18H21FN2O/c1-3-4-9-20-21-18(22)15-7-5-14(6-8-15)16-10-13(2)11-17(19)12-16/h5-8,10-12,20H,3-4,9H2,1-2H3,(H,21,22)
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US Patent
n/an/a 1.20E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM468610
PNG
(US10807944, Compound SR-4369)
Show SMILES CCCCNNC(=O)c1ccc(cc1)-c1cncnc1
Show InChI InChI=1S/C15H18N4O/c1-2-3-8-18-19-15(20)13-6-4-12(5-7-13)14-9-16-11-17-10-14/h4-7,9-11,18H,2-3,8H2,1H3,(H,19,20)
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US Patent
n/an/a 1.24E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM468613
PNG
(US10807944, Compound SR-4373)
Show SMILES CCCCNNC(=O)c1ccc(cc1)-c1cc(ccc1F)C(=O)OCC
Show InChI InChI=1S/C20H23FN2O3/c1-3-5-12-22-23-19(24)15-8-6-14(7-9-15)17-13-16(10-11-18(17)21)20(25)26-4-2/h6-11,13,22H,3-5,12H2,1-2H3,(H,23,24)
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US Patent
n/an/a 1.30E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM163621
PNG
(SR-3204 | US10807944, Compound RLS2-124)
Show SMILES CCCCNNC(=O)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C12H15F3N2O2/c1-2-3-8-16-17-11(18)9-4-6-10(7-5-9)19-12(13,14)15/h4-7,16H,2-3,8H2,1H3,(H,17,18)
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US Patent
n/an/a 1.35E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468598
PNG
(US10807944, Compound RLS2-290)
Show SMILES CCCCNNC(=O)c1ccncc1
Show InChI InChI=1S/C10H15N3O/c1-2-3-6-12-13-10(14)9-4-7-11-8-5-9/h4-5,7-8,12H,2-3,6H2,1H3,(H,13,14)
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US Patent
n/an/a 1.40E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM163619
PNG
(UF010 | US10807944, Compound UF010)
Show SMILES CCCCNNC(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C11H15BrN2O/c1-2-3-8-13-14-11(15)9-4-6-10(12)7-5-9/h4-7,13H,2-3,8H2,1H3,(H,14,15)
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n/an/a 1.50E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468592
PNG
(US10807944, Compound RLS2-255)
Show SMILES CCCNNC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C14H16N2O/c1-2-9-15-16-14(17)13-8-7-11-5-3-4-6-12(11)10-13/h3-8,10,15H,2,9H2,1H3,(H,16,17)
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n/an/a 1.65E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM163635
PNG
(SR-3298 | US10807944, Compound RLS2-225)
Show SMILES CN(C)c1ccc(cc1)C(=O)NNCC1CCCC1
Show InChI InChI=1S/C15H23N3O/c1-18(2)14-9-7-13(8-10-14)15(19)17-16-11-12-5-3-4-6-12/h7-10,12,16H,3-6,11H2,1-2H3,(H,17,19)
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n/an/a 1.67E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM163628
PNG
(SR-3212 | US10807944, Compound RLS2-137)
Show SMILES CCCNNC(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C10H13BrN2O/c1-2-7-12-13-10(14)8-3-5-9(11)6-4-8/h3-6,12H,2,7H2,1H3,(H,13,14)
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US Patent
n/an/a 1.70E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM163635
PNG
(SR-3298 | US10807944, Compound RLS2-225)
Show SMILES CN(C)c1ccc(cc1)C(=O)NNCC1CCCC1
Show InChI InChI=1S/C15H23N3O/c1-18(2)14-9-7-13(8-10-14)15(19)17-16-11-12-5-3-4-6-12/h7-10,12,16H,3-6,11H2,1-2H3,(H,17,19)
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US Patent
n/an/a 1.76E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM163620
PNG
(SR-3203 | US10807944, Compound RLS2-306)
Show SMILES CCCCNNC(=O)c1ccc(F)cc1
Show InChI InChI=1S/C11H15FN2O/c1-2-3-8-13-14-11(15)9-4-6-10(12)7-5-9/h4-7,13H,2-3,8H2,1H3,(H,14,15)
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n/an/a 1.78E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468586
PNG
(US10807944, Compound RLS2-238 | US10870618, Compou...)
Show SMILES CCCCNNC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C15H18N2O/c1-2-3-10-16-17-15(18)14-9-8-12-6-4-5-7-13(12)11-14/h4-9,11,16H,2-3,10H2,1H3,(H,17,18)
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n/an/a 1.79E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468605
PNG
(US10807944, Compound RLS3-6)
Show SMILES CCCCNNC(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C12H15F3N2O/c1-2-3-7-16-17-11(18)9-5-4-6-10(8-9)12(13,14)15/h4-6,8,16H,2-3,7H2,1H3,(H,17,18)
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n/an/a 1.88E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM163623
PNG
(SR-3206 | US10807944, Compound RLS2-126 | US108706...)
Show SMILES CCCCNNC(=O)c1ccc(OC)cc1
Show InChI InChI=1S/C12H18N2O2/c1-3-4-9-13-14-12(15)10-5-7-11(16-2)8-6-10/h5-8,13H,3-4,9H2,1-2H3,(H,14,15)
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n/an/a 1.91E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM468595
PNG
(US10807944, Compound RLS2-283)
Show SMILES CCCCCCNNC(=O)c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C17H28N2O/c1-5-6-7-8-13-18-19-16(20)14-9-11-15(12-10-14)17(2,3)4/h9-12,18H,5-8,13H2,1-4H3,(H,19,20)
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n/an/a 2.25E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468610
PNG
(US10807944, Compound SR-4369)
Show SMILES CCCCNNC(=O)c1ccc(cc1)-c1cncnc1
Show InChI InChI=1S/C15H18N4O/c1-2-3-8-18-19-15(20)13-6-4-12(5-7-13)14-9-16-11-17-10-14/h4-7,9-11,18H,2-3,8H2,1H3,(H,19,20)
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n/an/a 2.29E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM468611
PNG
(US10807944, Compound SR-4370)
Show SMILES CCCCNNC(=O)c1ccc(cc1)-c1cccc(F)c1F
Show InChI InChI=1S/C17H18F2N2O/c1-2-3-11-20-21-17(22)13-9-7-12(8-10-13)14-5-4-6-15(18)16(14)19/h4-10,20H,2-3,11H2,1H3,(H,21,22)
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n/an/a 2.30E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM468609
PNG
(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Show SMILES CCCCNNC(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C17H20N2O/c1-2-3-13-18-19-17(20)16-11-9-15(10-12-16)14-7-5-4-6-8-14/h4-12,18H,2-3,13H2,1H3,(H,19,20)
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n/an/a 2.43E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468576
PNG
(US10807944, Compound RLS2-128)
Show SMILES CCCCNNC(=O)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C11H15N3O3/c1-2-3-8-12-13-11(15)9-4-6-10(7-5-9)14(16)17/h4-7,12H,2-3,8H2,1H3,(H,13,15)
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n/an/a 2.47E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM163623
PNG
(SR-3206 | US10807944, Compound RLS2-126 | US108706...)
Show SMILES CCCCNNC(=O)c1ccc(OC)cc1
Show InChI InChI=1S/C12H18N2O2/c1-3-4-9-13-14-12(15)10-5-7-11(16-2)8-6-10/h5-8,13H,3-4,9H2,1-2H3,(H,14,15)
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n/an/a 2.52E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM468595
PNG
(US10807944, Compound RLS2-283)
Show SMILES CCCCCCNNC(=O)c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C17H28N2O/c1-5-6-7-8-13-18-19-16(20)14-9-11-15(12-10-14)17(2,3)4/h9-12,18H,5-8,13H2,1-4H3,(H,19,20)
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n/an/a 2.82E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM163635
PNG
(SR-3298 | US10807944, Compound RLS2-225)
Show SMILES CN(C)c1ccc(cc1)C(=O)NNCC1CCCC1
Show InChI InChI=1S/C15H23N3O/c1-18(2)14-9-7-13(8-10-14)15(19)17-16-11-12-5-3-4-6-12/h7-10,12,16H,3-6,11H2,1-2H3,(H,17,19)
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n/an/a 3.25E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM468592
PNG
(US10807944, Compound RLS2-255)
Show SMILES CCCNNC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C14H16N2O/c1-2-9-15-16-14(17)13-8-7-11-5-3-4-6-12(11)10-13/h3-8,10,15H,2,9H2,1H3,(H,16,17)
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n/an/a 3.50E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM468612
PNG
(US10807944, Compound SR-4372)
Show SMILES CCCCNNC(=O)c1ccc(cc1)-c1cc(C)cc(F)c1
Show InChI InChI=1S/C18H21FN2O/c1-3-4-9-20-21-18(22)15-7-5-14(6-8-15)16-10-13(2)11-17(19)12-16/h5-8,10-12,20H,3-4,9H2,1-2H3,(H,21,22)
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n/an/a 3.60E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM468611
PNG
(US10807944, Compound SR-4370)
Show SMILES CCCCNNC(=O)c1ccc(cc1)-c1cccc(F)c1F
Show InChI InChI=1S/C17H18F2N2O/c1-2-3-11-20-21-17(22)13-9-7-12(8-10-13)14-5-4-6-15(18)16(14)19/h4-10,20H,2-3,11H2,1H3,(H,21,22)
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n/an/a 3.70E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM468612
PNG
(US10807944, Compound SR-4372)
Show SMILES CCCCNNC(=O)c1ccc(cc1)-c1cc(C)cc(F)c1
Show InChI InChI=1S/C18H21FN2O/c1-3-4-9-20-21-18(22)15-7-5-14(6-8-15)16-10-13(2)11-17(19)12-16/h5-8,10-12,20H,3-4,9H2,1-2H3,(H,21,22)
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n/an/a 3.70E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM163625
PNG
(SR-3210 | US10807944, Compound RLS2-133)
Show SMILES CCCCNNC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C11H15ClN2O/c1-2-3-8-13-14-11(15)9-4-6-10(12)7-5-9/h4-7,13H,2-3,8H2,1H3,(H,14,15)
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n/an/a 3.75E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM163628
PNG
(SR-3212 | US10807944, Compound RLS2-137)
Show SMILES CCCNNC(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C10H13BrN2O/c1-2-7-12-13-10(14)8-3-5-9(11)6-4-8/h3-6,12H,2,7H2,1H3,(H,13,14)
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n/an/a 3.88E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM468613
PNG
(US10807944, Compound SR-4373)
Show SMILES CCCCNNC(=O)c1ccc(cc1)-c1cc(ccc1F)C(=O)OCC
Show InChI InChI=1S/C20H23FN2O3/c1-3-5-12-22-23-19(24)15-8-6-14(7-9-15)17-13-16(10-11-18(17)21)20(25)26-4-2/h6-11,13,22H,3-5,12H2,1-2H3,(H,23,24)
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n/an/a 3.90E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM468613
PNG
(US10807944, Compound SR-4373)
Show SMILES CCCCNNC(=O)c1ccc(cc1)-c1cc(ccc1F)C(=O)OCC
Show InChI InChI=1S/C20H23FN2O3/c1-3-5-12-22-23-19(24)15-8-6-14(7-9-15)17-13-16(10-11-18(17)21)20(25)26-4-2/h6-11,13,22H,3-5,12H2,1-2H3,(H,23,24)
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n/an/a 3.90E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468607
PNG
(US10807944, Compound RLS3-11)
Show SMILES CCCCNNC(=O)c1ccc(OC)cc1OC
Show InChI InChI=1S/C13H20N2O3/c1-4-5-8-14-15-13(16)11-7-6-10(17-2)9-12(11)18-3/h6-7,9,14H,4-5,8H2,1-3H3,(H,15,16)
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n/an/a 4.00E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM468598
PNG
(US10807944, Compound RLS2-290)
Show SMILES CCCCNNC(=O)c1ccncc1
Show InChI InChI=1S/C10H15N3O/c1-2-3-6-12-13-10(14)9-4-7-11-8-5-9/h4-5,7-8,12H,2-3,6H2,1H3,(H,13,14)
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n/an/a 4.28E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM468586
PNG
(US10807944, Compound RLS2-238 | US10870618, Compou...)
Show SMILES CCCCNNC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C15H18N2O/c1-2-3-10-16-17-15(18)14-9-8-12-6-4-5-7-13(12)11-14/h4-9,11,16H,2-3,10H2,1H3,(H,17,18)
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n/an/a 4.30E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468597
PNG
(US10807944, Compound RLS2-289 | US10870618, Compou...)
Show SMILES CCCCNNC(=O)c1cccnc1
Show InChI InChI=1S/C10H15N3O/c1-2-3-7-12-13-10(14)9-5-4-6-11-8-9/h4-6,8,12H,2-3,7H2,1H3,(H,13,14)
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n/an/a 4.35E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM163620
PNG
(SR-3203 | US10807944, Compound RLS2-306)
Show SMILES CCCCNNC(=O)c1ccc(F)cc1
Show InChI InChI=1S/C11H15FN2O/c1-2-3-8-13-14-11(15)9-4-6-10(12)7-5-9/h4-7,13H,2-3,8H2,1H3,(H,14,15)
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n/an/a 4.77E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM163625
PNG
(SR-3210 | US10807944, Compound RLS2-133)
Show SMILES CCCCNNC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C11H15ClN2O/c1-2-3-8-13-14-11(15)9-4-6-10(12)7-5-9/h4-7,13H,2-3,8H2,1H3,(H,14,15)
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n/an/a 5.82E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM468586
PNG
(US10807944, Compound RLS2-238 | US10870618, Compou...)
Show SMILES CCCCNNC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C15H18N2O/c1-2-3-10-16-17-15(18)14-9-8-12-6-4-5-7-13(12)11-14/h4-9,11,16H,2-3,10H2,1H3,(H,17,18)
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n/an/a 5.92E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM468613
PNG
(US10807944, Compound SR-4373)
Show SMILES CCCCNNC(=O)c1ccc(cc1)-c1cc(ccc1F)C(=O)OCC
Show InChI InChI=1S/C20H23FN2O3/c1-3-5-12-22-23-19(24)15-8-6-14(7-9-15)17-13-16(10-11-18(17)21)20(25)26-4-2/h6-11,13,22H,3-5,12H2,1-2H3,(H,23,24)
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n/an/a 6.50E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM468592
PNG
(US10807944, Compound RLS2-255)
Show SMILES CCCNNC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C14H16N2O/c1-2-9-15-16-14(17)13-8-7-11-5-3-4-6-12(11)10-13/h3-8,10,15H,2,9H2,1H3,(H,16,17)
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n/an/a 6.68E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM163633
PNG
(SR-3364 | US10807944, Compound RLS2-256)
Show SMILES Brc1ccc(cc1)C(=O)NNCC1CCCC1
Show InChI InChI=1S/C13H17BrN2O/c14-12-7-5-11(6-8-12)13(17)16-15-9-10-3-1-2-4-10/h5-8,10,15H,1-4,9H2,(H,16,17)
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US Patent
n/an/a 6.98E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM468610
PNG
(US10807944, Compound SR-4369)
Show SMILES CCCCNNC(=O)c1ccc(cc1)-c1cncnc1
Show InChI InChI=1S/C15H18N4O/c1-2-3-8-18-19-15(20)13-6-4-12(5-7-13)14-9-16-11-17-10-14/h4-7,9-11,18H,2-3,8H2,1H3,(H,19,20)
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US Patent
n/an/a 7.27E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM163632
PNG
(SR-3297 | US10807944, Compound RLS2-219)
Show SMILES Brc1ccc(cc1)C(=O)NNCCC1CCCC1
Show InChI InChI=1S/C14H19BrN2O/c15-13-7-5-12(6-8-13)14(18)17-16-10-9-11-3-1-2-4-11/h5-8,11,16H,1-4,9-10H2,(H,17,18)
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US Patent
n/an/a 7.40E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM468608
PNG
(US10807944, Compound RLS3-14)
Show SMILES CCCCNNC(=O)c1ccc(OCC)c(OCC)c1
Show InChI InChI=1S/C15H24N2O3/c1-4-7-10-16-17-15(18)12-8-9-13(19-5-2)14(11-12)20-6-3/h8-9,11,16H,4-7,10H2,1-3H3,(H,17,18)
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US Patent
n/an/a 7.40E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM163632
PNG
(SR-3297 | US10807944, Compound RLS2-219)
Show SMILES Brc1ccc(cc1)C(=O)NNCCC1CCCC1
Show InChI InChI=1S/C14H19BrN2O/c15-13-7-5-12(6-8-13)14(18)17-16-10-9-11-3-1-2-4-11/h5-8,11,16H,1-4,9-10H2,(H,17,18)
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US Patent
n/an/a 7.65E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468595
PNG
(US10807944, Compound RLS2-283)
Show SMILES CCCCCCNNC(=O)c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C17H28N2O/c1-5-6-7-8-13-18-19-16(20)14-9-11-15(12-10-14)17(2,3)4/h9-12,18H,5-8,13H2,1-4H3,(H,19,20)
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US Patent
n/an/a 8.08E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM163620
PNG
(SR-3203 | US10807944, Compound RLS2-306)
Show SMILES CCCCNNC(=O)c1ccc(F)cc1
Show InChI InChI=1S/C11H15FN2O/c1-2-3-8-13-14-11(15)9-4-6-10(12)7-5-9/h4-7,13H,2-3,8H2,1H3,(H,14,15)
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US Patent
n/an/a 8.63E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM163633
PNG
(SR-3364 | US10807944, Compound RLS2-256)
Show SMILES Brc1ccc(cc1)C(=O)NNCC1CCCC1
Show InChI InChI=1S/C13H17BrN2O/c14-12-7-5-11(6-8-12)13(17)16-15-9-10-3-1-2-4-10/h5-8,10,15H,1-4,9H2,(H,16,17)
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US Patent
n/an/a 8.81E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM163621
PNG
(SR-3204 | US10807944, Compound RLS2-124)
Show SMILES CCCCNNC(=O)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C12H15F3N2O2/c1-2-3-8-16-17-11(18)9-4-6-10(7-5-9)19-12(13,14)15/h4-7,16H,2-3,8H2,1H3,(H,17,18)
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US Patent
n/an/a 8.86E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM163621
PNG
(SR-3204 | US10807944, Compound RLS2-124)
Show SMILES CCCCNNC(=O)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C12H15F3N2O2/c1-2-3-8-16-17-11(18)9-4-6-10(7-5-9)19-12(13,14)15/h4-7,16H,2-3,8H2,1H3,(H,17,18)
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US Patent
n/an/a 9.09E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM163619
PNG
(UF010 | US10807944, Compound UF010)
Show SMILES CCCCNNC(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C11H15BrN2O/c1-2-3-8-13-14-11(15)9-4-6-10(12)7-5-9/h4-7,13H,2-3,8H2,1H3,(H,14,15)
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US Patent
n/an/a 9.10E+3n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM163630
PNG
(SR-3367 | US10807944, Compound RLS2-284)
Show SMILES CCCCCCNNC(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C13H19BrN2O/c1-2-3-4-5-10-15-16-13(17)11-6-8-12(14)9-7-11/h6-9,15H,2-5,10H2,1H3,(H,16,17)
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US Patent
n/an/a 1.03E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM163620
PNG
(SR-3203 | US10807944, Compound RLS2-306)
Show SMILES CCCCNNC(=O)c1ccc(F)cc1
Show InChI InChI=1S/C11H15FN2O/c1-2-3-8-13-14-11(15)9-4-6-10(12)7-5-9/h4-7,13H,2-3,8H2,1H3,(H,14,15)
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US Patent
n/an/a 1.09E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM468608
PNG
(US10807944, Compound RLS3-14)
Show SMILES CCCCNNC(=O)c1ccc(OCC)c(OCC)c1
Show InChI InChI=1S/C15H24N2O3/c1-4-7-10-16-17-15(18)12-8-9-13(19-5-2)14(11-12)20-6-3/h8-9,11,16H,4-7,10H2,1-3H3,(H,17,18)
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US Patent
n/an/a 1.18E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM163624
PNG
(SR-3208 | US10807944, Compound RLS2-131)
Show SMILES CCCCNNC(=O)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C13H21N3O/c1-4-5-10-14-15-13(17)11-6-8-12(9-7-11)16(2)3/h6-9,14H,4-5,10H2,1-3H3,(H,15,17)
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US Patent
n/an/a 1.31E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM163620
PNG
(SR-3203 | US10807944, Compound RLS2-306)
Show SMILES CCCCNNC(=O)c1ccc(F)cc1
Show InChI InChI=1S/C11H15FN2O/c1-2-3-8-13-14-11(15)9-4-6-10(12)7-5-9/h4-7,13H,2-3,8H2,1H3,(H,14,15)
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US Patent
n/an/a 1.32E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM468598
PNG
(US10807944, Compound RLS2-290)
Show SMILES CCCCNNC(=O)c1ccncc1
Show InChI InChI=1S/C10H15N3O/c1-2-3-6-12-13-10(14)9-4-7-11-8-5-9/h4-5,7-8,12H,2-3,6H2,1H3,(H,13,14)
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US Patent
n/an/a 1.37E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468606
PNG
(US10807944, Compound RLS3-20)
Show SMILES CCCCNNC(=O)c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C13H20N2O3/c1-4-5-8-14-15-13(16)10-6-7-11(17-2)12(9-10)18-3/h6-7,9,14H,4-5,8H2,1-3H3,(H,15,16)
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n/an/a 1.39E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM468597
PNG
(US10807944, Compound RLS2-289 | US10870618, Compou...)
Show SMILES CCCCNNC(=O)c1cccnc1
Show InChI InChI=1S/C10H15N3O/c1-2-3-7-12-13-10(14)9-5-4-6-11-8-9/h4-6,8,12H,2-3,7H2,1H3,(H,13,14)
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n/an/a 1.45E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM163620
PNG
(SR-3203 | US10807944, Compound RLS2-306)
Show SMILES CCCCNNC(=O)c1ccc(F)cc1
Show InChI InChI=1S/C11H15FN2O/c1-2-3-8-13-14-11(15)9-4-6-10(12)7-5-9/h4-7,13H,2-3,8H2,1H3,(H,14,15)
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n/an/a 1.51E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM163630
PNG
(SR-3367 | US10807944, Compound RLS2-284)
Show SMILES CCCCCCNNC(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C13H19BrN2O/c1-2-3-4-5-10-15-16-13(17)11-6-8-12(14)9-7-11/h6-9,15H,2-5,10H2,1H3,(H,16,17)
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n/an/a 1.61E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM163630
PNG
(SR-3367 | US10807944, Compound RLS2-284)
Show SMILES CCCCCCNNC(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C13H19BrN2O/c1-2-3-4-5-10-15-16-13(17)11-6-8-12(14)9-7-11/h6-9,15H,2-5,10H2,1H3,(H,16,17)
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n/an/a 2.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM468607
PNG
(US10807944, Compound RLS3-11)
Show SMILES CCCCNNC(=O)c1ccc(OC)cc1OC
Show InChI InChI=1S/C13H20N2O3/c1-4-5-8-14-15-13(16)11-7-6-10(17-2)9-12(11)18-3/h6-7,9,14H,4-5,8H2,1-3H3,(H,15,16)
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n/an/a 2.04E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM468576
PNG
(US10807944, Compound RLS2-128)
Show SMILES CCCCNNC(=O)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C11H15N3O3/c1-2-3-8-12-13-11(15)9-4-6-10(7-5-9)14(16)17/h4-7,12H,2-3,8H2,1H3,(H,13,15)
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US Patent
n/an/a 2.12E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM468576
PNG
(US10807944, Compound RLS2-128)
Show SMILES CCCCNNC(=O)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C11H15N3O3/c1-2-3-8-12-13-11(15)9-4-6-10(7-5-9)14(16)17/h4-7,12H,2-3,8H2,1H3,(H,13,15)
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US Patent
n/an/a 2.13E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM468607
PNG
(US10807944, Compound RLS3-11)
Show SMILES CCCCNNC(=O)c1ccc(OC)cc1OC
Show InChI InChI=1S/C13H20N2O3/c1-4-5-8-14-15-13(16)11-7-6-10(17-2)9-12(11)18-3/h6-7,9,14H,4-5,8H2,1-3H3,(H,15,16)
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US Patent
n/an/a 2.22E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM163633
PNG
(SR-3364 | US10807944, Compound RLS2-256)
Show SMILES Brc1ccc(cc1)C(=O)NNCC1CCCC1
Show InChI InChI=1S/C13H17BrN2O/c14-12-7-5-11(6-8-12)13(17)16-15-9-10-3-1-2-4-10/h5-8,10,15H,1-4,9H2,(H,16,17)
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US Patent
n/an/a 2.85E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM468606
PNG
(US10807944, Compound RLS3-20)
Show SMILES CCCCNNC(=O)c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C13H20N2O3/c1-4-5-8-14-15-13(16)10-6-7-11(17-2)12(9-10)18-3/h6-7,9,14H,4-5,8H2,1-3H3,(H,15,16)
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US Patent
n/an/a 3.01E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM468604
PNG
(US10807944, Compound RLS3-5)
Show SMILES CCCCNNC(=O)c1cccc(I)c1
Show InChI InChI=1S/C11H15IN2O/c1-2-3-7-13-14-11(15)9-5-4-6-10(12)8-9/h4-6,8,13H,2-3,7H2,1H3,(H,14,15)
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US Patent
n/an/a 3.14E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM468605
PNG
(US10807944, Compound RLS3-6)
Show SMILES CCCCNNC(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C12H15F3N2O/c1-2-3-7-16-17-11(18)9-5-4-6-10(8-9)12(13,14)15/h4-6,8,16H,2-3,7H2,1H3,(H,17,18)
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US Patent
n/an/a 3.53E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468600
PNG
(US10807944, Compound RLS2-305)
Show SMILES CCCCNNC(=O)c1ccccc1F
Show InChI InChI=1S/C11H15FN2O/c1-2-3-8-13-14-11(15)9-6-4-5-7-10(9)12/h4-7,13H,2-3,8H2,1H3,(H,14,15)
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US Patent
n/an/a 4.24E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM468604
PNG
(US10807944, Compound RLS3-5)
Show SMILES CCCCNNC(=O)c1cccc(I)c1
Show InChI InChI=1S/C11H15IN2O/c1-2-3-7-13-14-11(15)9-5-4-6-10(12)8-9/h4-6,8,13H,2-3,7H2,1H3,(H,14,15)
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US Patent
n/an/a 4.70E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468591
PNG
(US10807944, Compound RLS2-254)
Show SMILES O=C(NNCC1CCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C17H20N2O/c20-17(19-18-12-13-5-1-2-6-13)16-10-9-14-7-3-4-8-15(14)11-16/h3-4,7-11,13,18H,1-2,5-6,12H2,(H,19,20)
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US Patent
n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM163634
PNG
(SR-3365 | US10807944, Compound RLS2-257)
Show SMILES Brc1ccc(cc1)C(=O)NNCCCC1CCCC1
Show InChI InChI=1S/C15H21BrN2O/c16-14-9-7-13(8-10-14)15(19)18-17-11-3-6-12-4-1-2-5-12/h7-10,12,17H,1-6,11H2,(H,18,19)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468583
PNG
(US10807944, Compound RLS2-210)
Show SMILES CCCCNNC(=O)c1cc2ccccc2cc1O
Show InChI InChI=1S/C15H18N2O2/c1-2-3-8-16-17-15(19)13-9-11-6-4-5-7-12(11)10-14(13)18/h4-7,9-10,16,18H,2-3,8H2,1H3,(H,17,19)
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US Patent
n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM50320733
PNG
(2-naphthohydrazide | CHEMBL153973 | Naphthalene-2-...)
Show SMILES NNC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C11H10N2O/c12-13-11(14)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,12H2,(H,13,14)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM468590
PNG
(US10807944, Compound RLS2-249)
Show SMILES O=C(NNCCCC1CCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H24N2O/c22-19(21-20-13-5-8-15-6-1-2-7-15)18-12-11-16-9-3-4-10-17(16)14-18/h3-4,9-12,14-15,20H,1-2,5-8,13H2,(H,21,22)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM163634
PNG
(SR-3365 | US10807944, Compound RLS2-257)
Show SMILES Brc1ccc(cc1)C(=O)NNCCCC1CCCC1
Show InChI InChI=1S/C15H21BrN2O/c16-14-9-7-13(8-10-14)15(19)18-17-11-3-6-12-4-1-2-5-12/h7-10,12,17H,1-6,11H2,(H,18,19)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM468599
PNG
(US10807944, Compound RLS2-303)
Show SMILES CCCCNNC(=O)c1cccc(OCC)c1
Show InChI InChI=1S/C13H20N2O2/c1-3-5-9-14-15-13(16)11-7-6-8-12(10-11)17-4-2/h6-8,10,14H,3-5,9H2,1-2H3,(H,15,16)
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US Patent
n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM468582
PNG
(US10807944, Compound RLS2-187)
Show SMILES Cc1ccc(cc1)C(=O)NNC(C)(C)C
Show InChI InChI=1S/C12H18N2O/c1-9-5-7-10(8-6-9)11(15)13-14-12(2,3)4/h5-8,14H,1-4H3,(H,13,15)
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US Patent
n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM468606
PNG
(US10807944, Compound RLS3-20)
Show SMILES CCCCNNC(=O)c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C13H20N2O3/c1-4-5-8-14-15-13(16)10-6-7-11(17-2)12(9-10)18-3/h6-7,9,14H,4-5,8H2,1-3H3,(H,15,16)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM468591
PNG
(US10807944, Compound RLS2-254)
Show SMILES O=C(NNCC1CCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C17H20N2O/c20-17(19-18-12-13-5-1-2-6-13)16-10-9-14-7-3-4-8-15(14)11-16/h3-4,7-11,13,18H,1-2,5-6,12H2,(H,19,20)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468590
PNG
(US10807944, Compound RLS2-249)
Show SMILES O=C(NNCCCC1CCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H24N2O/c22-19(21-20-13-5-8-15-6-1-2-7-15)18-12-11-16-9-3-4-10-17(16)14-18/h3-4,9-12,14-15,20H,1-2,5-8,13H2,(H,21,22)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM468582
PNG
(US10807944, Compound RLS2-187)
Show SMILES Cc1ccc(cc1)C(=O)NNC(C)(C)C
Show InChI InChI=1S/C12H18N2O/c1-9-5-7-10(8-6-9)11(15)13-14-12(2,3)4/h5-8,14H,1-4H3,(H,13,15)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468599
PNG
(US10807944, Compound RLS2-303)
Show SMILES CCCCNNC(=O)c1cccc(OCC)c1
Show InChI InChI=1S/C13H20N2O2/c1-3-5-9-14-15-13(16)11-7-6-8-12(10-11)17-4-2/h6-8,10,14H,3-5,9H2,1-2H3,(H,15,16)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50320733
PNG
(2-naphthohydrazide | CHEMBL153973 | Naphthalene-2-...)
Show SMILES NNC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C11H10N2O/c12-13-11(14)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,12H2,(H,13,14)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468587
PNG
(US10807944, Compound RLS2-240)
Show SMILES CCNNC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C13H14N2O/c1-2-14-15-13(16)12-8-7-10-5-3-4-6-11(10)9-12/h3-9,14H,2H2,1H3,(H,15,16)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM163631
PNG
(SR-3213 | US10807944, Compound RLS2-138)
Show SMILES Brc1ccc(cc1)C(=O)NNCCc1ccccc1
Show InChI InChI=1S/C15H15BrN2O/c16-14-8-6-13(7-9-14)15(19)18-17-11-10-12-4-2-1-3-5-12/h1-9,17H,10-11H2,(H,18,19)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM163631
PNG
(SR-3213 | US10807944, Compound RLS2-138)
Show SMILES Brc1ccc(cc1)C(=O)NNCCc1ccccc1
Show InChI InChI=1S/C15H15BrN2O/c16-14-8-6-13(7-9-14)15(19)18-17-11-10-12-4-2-1-3-5-12/h1-9,17H,10-11H2,(H,18,19)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468604
PNG
(US10807944, Compound RLS3-5)
Show SMILES CCCCNNC(=O)c1cccc(I)c1
Show InChI InChI=1S/C11H15IN2O/c1-2-3-7-13-14-11(15)9-5-4-6-10(12)8-9/h4-6,8,13H,2-3,7H2,1H3,(H,14,15)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468603
PNG
(US10807944, Compound RLS3-4)
Show SMILES CCCCNNC(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C17H20N2O/c1-2-3-13-18-19-17(20)16-12-8-7-11-15(16)14-9-5-4-6-10-14/h4-12,18H,2-3,13H2,1H3,(H,19,20)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM468603
PNG
(US10807944, Compound RLS3-4)
Show SMILES CCCCNNC(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C17H20N2O/c1-2-3-13-18-19-17(20)16-12-8-7-11-15(16)14-9-5-4-6-10-14/h4-12,18H,2-3,13H2,1H3,(H,19,20)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM468603
PNG
(US10807944, Compound RLS3-4)
Show SMILES CCCCNNC(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C17H20N2O/c1-2-3-13-18-19-17(20)16-12-8-7-11-15(16)14-9-5-4-6-10-14/h4-12,18H,2-3,13H2,1H3,(H,19,20)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM468587
PNG
(US10807944, Compound RLS2-240)
Show SMILES CCNNC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C13H14N2O/c1-2-14-15-13(16)12-8-7-10-5-3-4-6-11(10)9-12/h3-9,14H,2H2,1H3,(H,15,16)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM468581
PNG
(US10807944, Compound RLS2-185)
Show SMILES CC(C)NNC(=O)c1ccccc1
Show InChI InChI=1S/C10H14N2O/c1-8(2)11-12-10(13)9-6-4-3-5-7-9/h3-8,11H,1-2H3,(H,12,13)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM163622
PNG
(SR-3205 | US10807944, Compound RLS2-125)
Show SMILES CCCCNNC(=O)c1ccccc1
Show InChI InChI=1S/C11H16N2O/c1-2-3-9-12-13-11(14)10-7-5-4-6-8-10/h4-8,12H,2-3,9H2,1H3,(H,13,14)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM468599
PNG
(US10807944, Compound RLS2-303)
Show SMILES CCCCNNC(=O)c1cccc(OCC)c1
Show InChI InChI=1S/C13H20N2O2/c1-3-5-9-14-15-13(16)11-7-6-8-12(10-11)17-4-2/h6-8,10,14H,3-5,9H2,1-2H3,(H,15,16)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM468587
PNG
(US10807944, Compound RLS2-240)
Show SMILES CCNNC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C13H14N2O/c1-2-14-15-13(16)12-8-7-10-5-3-4-6-11(10)9-12/h3-9,14H,2H2,1H3,(H,15,16)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM468583
PNG
(US10807944, Compound RLS2-210)
Show SMILES CCCCNNC(=O)c1cc2ccccc2cc1O
Show InChI InChI=1S/C15H18N2O2/c1-2-3-8-16-17-15(19)13-9-11-6-4-5-7-12(11)10-14(13)18/h4-7,9-10,16,18H,2-3,8H2,1H3,(H,17,19)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM468581
PNG
(US10807944, Compound RLS2-185)
Show SMILES CC(C)NNC(=O)c1ccccc1
Show InChI InChI=1S/C10H14N2O/c1-8(2)11-12-10(13)9-6-4-3-5-7-9/h3-8,11H,1-2H3,(H,12,13)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM163631
PNG
(SR-3213 | US10807944, Compound RLS2-138)
Show SMILES Brc1ccc(cc1)C(=O)NNCCc1ccccc1
Show InChI InChI=1S/C15H15BrN2O/c16-14-8-6-13(7-9-14)15(19)18-17-11-10-12-4-2-1-3-5-12/h1-9,17H,10-11H2,(H,18,19)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM163622
PNG
(SR-3205 | US10807944, Compound RLS2-125)
Show SMILES CCCCNNC(=O)c1ccccc1
Show InChI InChI=1S/C11H16N2O/c1-2-3-9-12-13-11(14)10-7-5-4-6-8-10/h4-8,12H,2-3,9H2,1H3,(H,13,14)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM163622
PNG
(SR-3205 | US10807944, Compound RLS2-125)
Show SMILES CCCCNNC(=O)c1ccccc1
Show InChI InChI=1S/C11H16N2O/c1-2-3-9-12-13-11(14)10-7-5-4-6-8-10/h4-8,12H,2-3,9H2,1H3,(H,13,14)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM468590
PNG
(US10807944, Compound RLS2-249)
Show SMILES O=C(NNCCCC1CCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H24N2O/c22-19(21-20-13-5-8-15-6-1-2-7-15)18-12-11-16-9-3-4-10-17(16)14-18/h3-4,9-12,14-15,20H,1-2,5-8,13H2,(H,21,22)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM468583
PNG
(US10807944, Compound RLS2-210)
Show SMILES CCCCNNC(=O)c1cc2ccccc2cc1O
Show InChI InChI=1S/C15H18N2O2/c1-2-3-8-16-17-15(19)13-9-11-6-4-5-7-12(11)10-14(13)18/h4-7,9-10,16,18H,2-3,8H2,1H3,(H,17,19)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM163624
PNG
(SR-3208 | US10807944, Compound RLS2-131)
Show SMILES CCCCNNC(=O)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C13H21N3O/c1-4-5-10-14-15-13(17)11-6-8-12(9-7-11)16(2)3/h6-9,14H,4-5,10H2,1-3H3,(H,15,17)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468581
PNG
(US10807944, Compound RLS2-185)
Show SMILES CC(C)NNC(=O)c1ccccc1
Show InChI InChI=1S/C10H14N2O/c1-8(2)11-12-10(13)9-6-4-3-5-7-9/h3-8,11H,1-2H3,(H,12,13)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468582
PNG
(US10807944, Compound RLS2-187)
Show SMILES Cc1ccc(cc1)C(=O)NNC(C)(C)C
Show InChI InChI=1S/C12H18N2O/c1-9-5-7-10(8-6-9)11(15)13-14-12(2,3)4/h5-8,14H,1-4H3,(H,13,15)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM50320733
PNG
(2-naphthohydrazide | CHEMBL153973 | Naphthalene-2-...)
Show SMILES NNC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C11H10N2O/c12-13-11(14)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,12H2,(H,13,14)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM468591
PNG
(US10807944, Compound RLS2-254)
Show SMILES O=C(NNCC1CCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C17H20N2O/c20-17(19-18-12-13-5-1-2-6-13)16-10-9-14-7-3-4-8-15(14)11-16/h3-4,7-11,13,18H,1-2,5-6,12H2,(H,19,20)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM163634
PNG
(SR-3365 | US10807944, Compound RLS2-257)
Show SMILES Brc1ccc(cc1)C(=O)NNCCCC1CCCC1
Show InChI InChI=1S/C15H21BrN2O/c16-14-9-7-13(8-10-14)15(19)18-17-11-3-6-12-4-1-2-5-12/h7-10,12,17H,1-6,11H2,(H,18,19)
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Similars

US Patent
n/an/a>5.00E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM468597
PNG
(US10807944, Compound RLS2-289 | US10870618, Compou...)
Show SMILES CCCCNNC(=O)c1cccnc1
Show InChI InChI=1S/C10H15N3O/c1-2-3-7-12-13-10(14)9-5-4-6-11-8-9/h4-6,8,12H,2-3,7H2,1H3,(H,13,14)
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n/an/a 5.67E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM468600
PNG
(US10807944, Compound RLS2-305)
Show SMILES CCCCNNC(=O)c1ccccc1F
Show InChI InChI=1S/C11H15FN2O/c1-2-3-8-13-14-11(15)9-6-4-5-7-10(9)12/h4-7,13H,2-3,8H2,1H3,(H,14,15)
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n/an/a 7.23E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM468600
PNG
(US10807944, Compound RLS2-305)
Show SMILES CCCCNNC(=O)c1ccccc1F
Show InChI InChI=1S/C11H15FN2O/c1-2-3-8-13-14-11(15)9-6-4-5-7-10(9)12/h4-7,13H,2-3,8H2,1H3,(H,14,15)
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n/an/a 7.96E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM468605
PNG
(US10807944, Compound RLS3-6)
Show SMILES CCCCNNC(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C12H15F3N2O/c1-2-3-7-16-17-11(18)9-5-4-6-10(8-9)12(13,14)15/h4-6,8,16H,2-3,7H2,1H3,(H,17,18)
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n/an/a 9.33E+4n/an/an/an/an/an/a



University of Florida Research Foundation, Inc.; The Scripps Research Institute

US Patent


Assay Description
These SAR data indicate that a tripartite structure of this scaffold with a central C(O)NHNH unit flanked by a phenyl group and a short aliphatic...


US Patent US10807944 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%