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Patent code US10807952

Compile Data Set for Download or QSAR
Found 101 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Complement factor D


(Homo sapiens (Human))
BDBM468620
PNG
((2S,4R)-N-(2'- chloro-2- fluorobiphenyl-3- yl)-1-(...)
Show SMILES F[C@@H]1C[C@H](N(C1)C(=O)Cc1cccc(c1)C#N)C(=O)Nc1cccc(c1F)-c1ccccc1Cl
Show InChI InChI=1S/C26H20ClF2N3O2/c27-21-9-2-1-7-19(21)20-8-4-10-22(25(20)29)31-26(34)23-13-18(28)15-32(23)24(33)12-16-5-3-6-17(11-16)14-30/h1-11,18,23H,12-13,15H2,(H,31,34)/t18-,23+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468622
PNG
(1-(2-((2S,4R)-2-(3- (2-amino-7-chloro- 1H- benzo[d...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3nc(N)[nH]c3c2Cl)c2ccccc12
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468629
PNG
(1-(2-((2S,4R)-2-(2'- chloro-2- fluorobiphenyl-3- y...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)c2cc(sc12)C(F)(F)F
Show InChI InChI=1S/C26H19ClF5N5O3S/c27-15-6-2-1-4-13(15)14-5-3-7-16(21(14)29)34-25(40)18-8-12(28)10-36(18)20(38)11-37-17-9-19(26(30,31)32)41-23(17)22(35-37)24(33)39/h1-7,9,12,18H,8,10-11H2,(H2,33,39)(H,34,40)/t12-,18+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468633
PNG
(1-(2-((2S,4R)-4- fluoro-2-(2-fluoro- 3-(pyrazolo[1...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2cnc3ccnn3c2)c2ccccc12
Show InChI InChI=1S/C27H22F2N8O3/c28-16-10-21(35(13-16)23(38)14-36-20-7-2-1-4-18(20)25(34-36)26(30)39)27(40)33-19-6-3-5-17(24(19)29)15-11-31-22-8-9-32-37(22)12-15/h1-9,11-12,16,21H,10,13-14H2,(H2,30,39)(H,33,40)/t16-,21+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468641
PNG
(1-(2-((2S,4R)-2- ((2'-chloro-2- fluoro-[1,1'- biph...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)c2cc(ccc12)S(F)(F)(F)(F)F
Show InChI InChI=1S/C27H21ClF7N5O3S/c28-19-6-2-1-4-16(19)17-5-3-7-20(24(17)30)37-27(43)22-10-14(29)12-39(22)23(41)13-40-21-11-15(44(31,32,33,34)35)8-9-18(21)25(38-40)26(36)42/h1-9,11,14,22H,10,12-13H2,(H2,36,42)(H,37,43)/t14-,22+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468644
PNG
((2S,4R)-1-(2-(3- bromo-5- methoxyphenyl) acetyl)-N...)
Show SMILES COc1cc(Br)cc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)c1
Show InChI InChI=1S/C26H22BrClF2N2O3/c1-35-18-10-15(9-16(27)12-18)11-24(33)32-14-17(29)13-23(32)26(34)31-22-8-4-6-20(25(22)30)19-5-2-3-7-21(19)28/h2-10,12,17,23H,11,13-14H2,1H3,(H,31,34)/t17-,23+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468655
PNG
(1-(2-((2S,4R)-2-(3- (5-chloro-3-oxo- 1,2,3,4- tetr...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3NCC(=O)Nc3c2Cl)c2ccccc12
Show InChI InChI=1S/C29H24ClF2N7O4/c30-24-15(8-9-19-27(24)36-22(40)11-34-19)16-5-3-6-18(25(16)32)35-29(43)21-10-14(31)12-38(21)23(41)13-39-20-7-2-1-4-17(20)26(37-39)28(33)42/h1-9,14,21,34H,10-13H2,(H2,33,42)(H,35,43)(H,36,40)/t14-,21+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468664
PNG
(US10807952, Cmp No. 69 | tert-butyl ((3- acetyl-1-...)
Show SMILES CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(Br)n2)c2ccc(cc12)S(C)(=O)=NC(=O)OC(C)(C)C
Show InChI InChI=1S/C28H31BrFN5O6S/c1-16(36)20-14-34(21-10-9-18(12-19(20)21)42(5,40)33-27(39)41-28(2,3)4)15-25(37)35-13-17(30)11-22(35)26(38)32-24-8-6-7-23(29)31-24/h6-10,12,14,17,22H,11,13,15H2,1-5H3,(H,31,32,38)/t17-,22+,42?/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468672
PNG
((4R)-1-(2-(3- carbamoyl-5- hydroxyphenyl)acetyl)- ...)
Show SMILES NC(=O)c1cc(O)cc(CC(=O)N2C[C@H](F)CC2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)c1
Show InChI InChI=1S/C26H22ClF2N3O4/c27-20-6-2-1-4-18(20)19-5-3-7-21(24(19)29)31-26(36)22-12-16(28)13-32(22)23(34)10-14-8-15(25(30)35)11-17(33)9-14/h1-9,11,16,22,33H,10,12-13H2,(H2,30,35)(H,31,36)/t16-,22?/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468565
PNG
((2S,4R)-1-(2-(3- acetyl-1H-indazol- 1-yl)acetyl)-N...)
Show SMILES CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3[nH]cnc3c2Cl)c2ccccc12
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468579
PNG
(1-(2-((2S,4R)-2-(2'- chloro-2-fluoro-5'- ((E)-1- (...)
Show SMILES CO\N=C(/C)c1ccc(Cl)c(c1)-c1cccc(NC(=O)[C@@H]2C[C@@H](F)CN2C(=O)Cn2nc(C(N)=O)c3ccccc23)c1F
Show InChI InChI=1S/C30H27ClF2N6O4/c1-16(37-43-2)17-10-11-22(31)21(12-17)19-7-5-8-23(27(19)33)35-30(42)25-13-18(32)14-38(25)26(40)15-39-24-9-4-3-6-20(24)28(36-39)29(34)41/h3-12,18,25H,13-15H2,1-2H3,(H2,34,41)(H,35,42)/b37-16+/t18-,25+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468601
PNG
(1-(2-((2S,4R)-2-(3- (4-chloro-1H- indazol-5-yl)-2-...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3[nH]ncc3c2Cl)c2ccccc12
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468621
PNG
(1-(2-((2S,4R)-4- fluoro-2-(2-fluoro- 3-(1H-indol-6...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3cc[nH]c3c2)c2ccccc12
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468631
PNG
(1-(2-((2S,4R)-2-(3- (3-acetyl-1H-indol- 6-yl)-2- f...)
Show SMILES CC(=O)c1c[nH]c2cc(ccc12)-c1cccc(NC(=O)[C@@H]2C[C@@H](F)CN2C(=O)Cn2nc(C(N)=O)c3ccccc23)c1F
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468647
PNG
(US10807952, Cmp No. 51 | tert-butyl 2-(3'- ((2S,4R...)
Show SMILES CC(C)(C)OC(=O)NCC(=O)c1ccc(Cl)c(c1)-c1cccc(NC(=O)[C@@H]2C[C@@H](F)CN2C(=O)Cn2nc(C(N)=O)c3ccccc23)c1F
Show InChI InChI=1S/C34H33ClF2N6O6/c1-34(2,3)49-33(48)39-15-27(44)18-11-12-23(35)22(13-18)20-8-6-9-24(29(20)37)40-32(47)26-14-19(36)16-42(26)28(45)17-43-25-10-5-4-7-21(25)30(41-43)31(38)46/h4-13,19,26H,14-17H2,1-3H3,(H2,38,46)(H,39,48)(H,40,47)/t19-,26+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468648
PNG
(1-(2-((2S,4R)-2-(3- (benzo[d]thiazol-5- yl)-2- flu...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3scnc3c2)c2ccccc12
Show InChI InChI=1S/C28H22F2N6O3S/c29-16-11-22(35(12-16)24(37)13-36-21-7-2-1-4-18(21)26(34-36)27(31)38)28(39)33-19-6-3-5-17(25(19)30)15-8-9-23-20(10-15)32-14-40-23/h1-10,14,16,22H,11-13H2,(H2,31,38)(H,33,39)/t16-,22+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468693
PNG
((2S,4R)-1-(2-(3- acetyl-1H-indazol- 1-yl)acetyl)-4...)
Show SMILES CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(-c3ccc4sc(O)nc4c3)c2F)c2ccccc12
Show InChI InChI=1S/C29H23F2N5O4S/c1-15(37)27-19-5-2-3-8-22(19)36(34-27)14-25(38)35-13-17(30)12-23(35)28(39)32-20-7-4-6-18(26(20)31)16-9-10-24-21(11-16)33-29(40)41-24/h2-11,17,23H,12-14H2,1H3,(H,32,39)(H,33,40)/t17-,23+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468571
PNG
(5-bromo-1-(2- ((2S,4R)-2-(3-(4- chloro-1H- benzo[d...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3[nH]cnc3c2Cl)c2ccc(Br)cc12
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468585
PNG
(1-(2-((2S,4R)-2-(3- (4-chloro-2-oxo- 2,3-dihydro-1...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3[nH]c(=O)[nH]c3c2Cl)c2ccccc12
Show InChI InChI=1S/C28H20ClF2N7O4/c29-22-14(8-9-18-25(22)35-28(42)34-18)15-5-3-6-17(23(15)31)33-27(41)20-10-13(30)11-37(20)21(39)12-38-19-7-2-1-4-16(19)24(36-38)26(32)40/h1-9,13,20H,10-12H2,(H2,32,40)(H,33,41)/t13-,20+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468625
PNG
(1-(2-((2S,4R)-2-(6- bromopyridin-2- ylcarbamoyl)-4...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(Br)n2)c2cc(Cn3cc(nn3)C3CC3)sc12
Show InChI InChI=1S/C24H23BrFN9O3S/c25-18-2-1-3-19(28-18)29-24(38)17-6-13(26)8-34(17)20(36)11-35-16-7-14(39-22(16)21(31-35)23(27)37)9-33-10-15(30-32-33)12-4-5-12/h1-3,7,10,12-13,17H,4-6,8-9,11H2,(H2,27,37)(H,28,29,38)/t13-,17+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468649
PNG
(1-(2-((2S,4R)-2-(3- (benzo[d]thiazol-6- yl)-2- flu...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3ncsc3c2)c2ccccc12
Show InChI InChI=1S/C28H22F2N6O3S/c29-16-11-22(35(12-16)24(37)13-36-21-7-2-1-4-18(21)26(34-36)27(31)38)28(39)33-20-6-3-5-17(25(20)30)15-8-9-19-23(10-15)40-14-32-19/h1-10,14,16,22H,11-13H2,(H2,31,38)(H,33,39)/t16-,22+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468652
PNG
(1-(2-((2S,4R)-2-(3- (benzo[d]oxazol-6- yl)-2- fluo...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3ncoc3c2)c2ccccc12
Show InChI InChI=1S/C28H22F2N6O4/c29-16-11-22(35(12-16)24(37)13-36-21-7-2-1-4-18(21)26(34-36)27(31)38)28(39)33-20-6-3-5-17(25(20)30)15-8-9-19-23(10-15)40-14-32-19/h1-10,14,16,22H,11-13H2,(H2,31,38)(H,33,39)/t16-,22+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468653
PNG
(1-(2-((2S,4R)-2-(3- (benzo[d]oxazol-5- yl)-2- fluo...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3ocnc3c2)c2ccccc12
Show InChI InChI=1S/C28H22F2N6O4/c29-16-11-22(35(12-16)24(37)13-36-21-7-2-1-4-18(21)26(34-36)27(31)38)28(39)33-19-6-3-5-17(25(19)30)15-8-9-23-20(10-15)32-14-40-23/h1-10,14,16,22H,11-13H2,(H2,31,38)(H,33,39)/t16-,22+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468681
PNG
(1-(2-((2S,4R)-4- fluoro-2-((2-fluoro- 3-(2-oxoindo...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3CC(=O)Nc3c2)c2ccccc12
Show InChI InChI=1S/C29H24F2N6O4/c30-17-12-23(36(13-17)25(39)14-37-22-7-2-1-4-19(22)27(35-37)28(32)40)29(41)34-20-6-3-5-18(26(20)31)15-8-9-16-11-24(38)33-21(16)10-15/h1-10,17,23H,11-14H2,(H2,32,40)(H,33,38)(H,34,41)/t17-,23+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468684
PNG
(1-(2-((2S,4R)-4- fluoro-2-((2-fluoro- 3-(3-oxoisoi...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3CNC(=O)c3c2)c2ccccc12
Show InChI InChI=1S/C29H24F2N6O4/c30-17-11-23(36(13-17)24(38)14-37-22-7-2-1-4-19(22)26(35-37)27(32)39)29(41)34-21-6-3-5-18(25(21)31)15-8-9-16-12-33-28(40)20(16)10-15/h1-10,17,23H,11-14H2,(H2,32,39)(H,33,40)(H,34,41)/t17-,23+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468690
PNG
((2S,4R)-1-(2-(3- acetyl-1H-indazol- 1-yl)acetyl)-N...)
Show SMILES CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(-c3ccc4sc(N)nc4c3)c2F)c2ccccc12
Show InChI InChI=1S/C29H24F2N6O3S/c1-15(38)27-19-5-2-3-8-22(19)37(35-27)14-25(39)36-13-17(30)12-23(36)28(40)33-20-7-4-6-18(26(20)31)16-9-10-24-21(11-16)34-29(32)41-24/h2-11,17,23H,12-14H2,1H3,(H2,32,34)(H,33,40)/t17-,23+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468558
PNG
((2S,4R)-1-(2-(3- acetyl-1H-indol-1- yl)acetyl)-N-(...)
Show SMILES CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3[nH]cnc3c2Cl)c2ccccc12
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468577
PNG
(1-(2-((2S,4R)-2-(3- (1H- benzo[d]imidazol- 5-yl)-2...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3[nH]cnc3c2)c2ccccc12
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468588
PNG
(1-(2-((2S,4R)-2-(3- (4-chloro-2-methyl- 1H- benzo[...)
Show SMILES Cc1nc2c(Cl)c(ccc2[nH]1)-c1cccc(NC(=O)[C@@H]2C[C@@H](F)CN2C(=O)Cn2nc(C(N)=O)c3ccccc23)c1F
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468634
PNG
(6-(2-((2S,4R)-2-(2'- chloro-2- fluorobiphenyl-3- y...)
Show SMILES NC(=O)c1cccc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)n1
Show InChI InChI=1S/C25H21ClF2N4O3/c26-18-8-2-1-6-16(18)17-7-4-9-19(23(17)28)31-25(35)21-11-14(27)13-32(21)22(33)12-15-5-3-10-20(30-15)24(29)34/h1-10,14,21H,11-13H2,(H2,29,34)(H,31,35)/t14-,21+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468636
PNG
(1-(2-((2S,4R)-2- ((6-bromopyridin- 2-yl)carbamoyl)...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(Br)n2)c2cc(ccc12)S(F)(F)(F)(F)F
Show InChI InChI=1S/C20H17BrF6N6O3S/c21-15-2-1-3-16(29-15)30-20(36)14-6-10(22)8-32(14)17(34)9-33-13-7-11(37(23,24,25,26)27)4-5-12(13)18(31-33)19(28)35/h1-5,7,10,14H,6,8-9H2,(H2,28,35)(H,29,30,36)/t10-,14+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468645
PNG
(1-(2-((2S,4R)-2-(5'- carbamoyl-2'- chloro-2- fluor...)
Show SMILES Cc1cc2n(CC(=O)N3C[C@H](F)C[C@H]3C(=O)Nc3cccc(c3F)-c3cc(ccc3Cl)C(N)=O)nc(C(N)=O)c2s1
Show InChI InChI=1S/C27H23ClF2N6O4S/c1-12-7-19-24(41-12)23(26(32)39)34-36(19)11-21(37)35-10-14(29)9-20(35)27(40)33-18-4-2-3-15(22(18)30)16-8-13(25(31)38)5-6-17(16)28/h2-8,14,20H,9-11H2,1H3,(H2,31,38)(H2,32,39)(H,33,40)/t14-,20+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468670
PNG
(US10807952, Cmp No. 76 | methyl 2-amino-6- (3-((2S...)
Show SMILES COC(=O)c1cc(cc2[nH]c(N)nc12)-c1cccc(NC(=O)[C@@H]2C[C@@H](F)CN2C(=O)Cn2nc(C(N)=O)c3ccccc23)c1F
PDB

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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468674
PNG
(US10807952, Cmp No. 81 | methyl (6-(3- ((2S,4R)-1-...)
Show SMILES COC(=O)Nc1nc2ccc(c(Cl)c2[nH]1)-c1cccc(NC(=O)[C@@H]2C[C@@H](F)CN2C(=O)Cn2nc(C(C)=O)c3ccccc23)c1F
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468675
PNG
((2S,4R)-1-(2-(3- acetyl-1H-indazol- 1-yl)acetyl)-4...)
Show SMILES CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3NC(=O)CCc3c2)c2ccccc12
Show InChI InChI=1S/C31H27F2N5O4/c1-17(39)30-22-5-2-3-8-25(22)38(36-30)16-28(41)37-15-20(32)14-26(37)31(42)35-24-7-4-6-21(29(24)33)18-9-11-23-19(13-18)10-12-27(40)34-23/h2-9,11,13,20,26H,10,12,14-16H2,1H3,(H,34,40)(H,35,42)/t20-,26+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468688
PNG
((2S,4R)-1-(2-(3- acetyl-1H-indazol- 1-yl)acetyl)-4...)
Show SMILES CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3CNC(=O)Nc3c2)c2ccccc12
Show InChI InChI=1S/C30H26F2N6O4/c1-16(39)28-21-5-2-3-8-24(21)38(36-28)15-26(40)37-14-19(31)12-25(37)29(41)34-22-7-4-6-20(27(22)32)17-9-10-18-13-33-30(42)35-23(18)11-17/h2-11,19,25H,12-15H2,1H3,(H,34,41)(H2,33,35,42)/t19-,25+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468689
PNG
((2S,4R)-1-(2-(3- acetyl-1H-indazol- 1-yl)acetyl)-N...)
Show SMILES CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2nc(Cl)c3nc[nH]c3n2)c2ccccc12
PDB

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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468575
PNG
((1R,3S,5R)-2-(2-(3- acetyl-1H-indazol- 1-yl)acetyl...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3[nH]cnc3c2Cl)c2ccccc12
PDB

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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468578
PNG
((2S,3R)-2-(2-(3- acetyl-1H-indol-1- yl)acetamido)-...)
Show SMILES C[C@@H](O)[C@H](NC(=O)Cn1cc(C(C)=O)c2ccccc12)C(=O)Nc1cccc(c1F)-c1ccccc1Cl
Show InChI InChI=1S/C28H25ClFN3O4/c1-16(34)21-14-33(24-13-6-4-9-19(21)24)15-25(36)32-27(17(2)35)28(37)31-23-12-7-10-20(26(23)30)18-8-3-5-11-22(18)29/h3-14,17,27,35H,15H2,1-2H3,(H,31,37)(H,32,36)/t17-,27+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468580
PNG
(1-(2-((2S,4R)-2-(3- (4-chloro-2- (trifluoromethyl)...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3[nH]c(nc3c2Cl)C(F)(F)F)c2ccccc12
PDB

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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468614
PNG
(1-(2-((2S,4R)-2-(3- (2-acetyl-7-chloro- 1H- benzo[...)
Show SMILES CC(=O)c1nc2ccc(c(Cl)c2[nH]1)-c1cccc(NC(=O)[C@@H]2C[C@@H](F)CN2C(=O)Cn2nc(C(N)=O)c3ccccc23)c1F
PDB

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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468623
PNG
(1-(2-((2S,4R)-2-(3- (7-chloro-1H- benzo[d]imidazol...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(-c3nc4cccc(Cl)c4[nH]3)c2F)c2ccccc12
PDB

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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468624
PNG
(1-(2-((2S,4R)-4- fluoro-2-(2-fluoro- 3-(1H-indazol...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3cn[nH]c3c2)c2ccccc12
PDB

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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468628
PNG
(1-(2-((2S,4R)-2-(3- (3-cyano-1H- indazol-6-yl)-2- ...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(-c3ccc4c(n[nH]c4c3)C#N)c2F)c2ccccc12
PDB

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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468663
PNG
(1-(2-((2S,4R)-2-(3- (benzo[c][1,2,5] oxadiazol-5-y...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(-c3ccc4nonc4c3)c2F)c2ccccc12
Show InChI InChI=1S/C27H21F2N7O4/c28-15-11-22(35(12-15)23(37)13-36-21-7-2-1-4-17(21)25(32-36)26(30)38)27(39)31-19-6-3-5-16(24(19)29)14-8-9-18-20(10-14)34-40-33-18/h1-10,15,22H,11-13H2,(H2,30,38)(H,31,39)/t15-,22+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468665
PNG
((2S,4R)-1-(2-(3- acetyl-5-(S- methylsulfonimidoyl)...)
Show SMILES CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(Br)n2)c2ccc(cc12)S(C)(=N)=O
Show InChI InChI=1S/C22H22BrFN6O4S/c1-12(31)21-15-9-14(35(2,25)34)6-7-16(15)30(28-21)11-20(32)29-10-13(24)8-17(29)22(33)27-19-5-3-4-18(23)26-19/h3-7,9,13,17,25H,8,10-11H2,1-2H3,(H,26,27,33)/t13-,17+,35?/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468666
PNG
(1-(2-((2S,4R)-4- fluoro-2-(2-fluoro- 3-(1H-thieno[...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(-c3n[nH]c4ccsc34)c2F)c2ccccc12
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468667
PNG
((2S,4R)-1-(2-(3- carbamimidoyl-5- methyl-1H- thien...)
Show SMILES Cc1cc2n(CC(=O)N3C[C@H](F)C[C@H]3C(=O)Nc3cccc(c3F)-c3ccccc3Cl)nc(C(N)=N)c2s1
Show InChI InChI=1S/C26H23ClF2N6O2S/c1-13-9-19-24(38-13)23(25(30)31)33-35(19)12-21(36)34-11-14(28)10-20(34)26(37)32-18-8-4-6-16(22(18)29)15-5-2-3-7-17(15)27/h2-9,14,20H,10-12H2,1H3,(H3,30,31)(H,32,37)/t14-,20+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468668
PNG
((2S,4R)-N-(2'- chloro-2-fluoro- [1,1'-biphenyl]-3-...)
Show SMILES F[C@H]1CC([C@@H](C1)C(=O)Nc1cccc(c1F)-c1ccccc1Cl)C(=O)Cn1c2ccccc2[nH]c1=O
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468676
PNG
((2S,4R)-1-(2-(3- acetyl-1H-indazol- 1-yl)acetyl)-4...)
Show SMILES CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(-c3ccc4nccnc4c3)c2F)c2ccccc12
Show InChI InChI=1S/C30H24F2N6O3/c1-17(39)29-21-5-2-3-8-25(21)38(36-29)16-27(40)37-15-19(31)14-26(37)30(41)35-23-7-4-6-20(28(23)32)18-9-10-22-24(13-18)34-12-11-33-22/h2-13,19,26H,14-16H2,1H3,(H,35,41)/t19-,26+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468687
PNG
((2S,4R)-1-(2-(3- acetyl-1H-indazol- 1-yl)acetyl)-N...)
Show SMILES CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2cc(ccc2Cl)C(=O)NC#N)c2ccccc12
Show InChI InChI=1S/C30H23ClF2N6O4/c1-16(40)28-20-5-2-3-8-24(20)39(37-28)14-26(41)38-13-18(32)12-25(38)30(43)36-23-7-4-6-19(27(23)33)21-11-17(9-10-22(21)31)29(42)35-15-34/h2-11,18,25H,12-14H2,1H3,(H,35,42)(H,36,43)/t18-,25+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468589
PNG
(1-(2-((2S,4R)-2-(3- (3-cyano-1H- indazol-5-yl)-2- ...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(-c3ccc4[nH]nc(C#N)c4c3)c2F)c2ccccc12
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468630
PNG
(1-(2-((2S,4R)-2-(6- bromopyridin-2- ylcarbamoyl)-4...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(Br)n2)c2cc(sc12)C(F)(F)F
Show InChI InChI=1S/C19H15BrF4N6O3S/c20-12-2-1-3-13(26-12)27-18(33)10-4-8(21)6-29(10)14(31)7-30-9-5-11(19(22,23)24)34-16(9)15(28-30)17(25)32/h1-3,5,8,10H,4,6-7H2,(H2,25,32)(H,26,27,33)/t8-,10+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468635
PNG
(1-(2-((2S,4R)-2-(5'- carbamoyl-2'- chloro-2- fluor...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2cc(ccc2Cl)C(N)=O)c2cc(sc12)C(F)(F)F
Show InChI InChI=1S/C27H20ClF5N6O4S/c28-15-5-4-11(24(34)41)6-14(15)13-2-1-3-16(21(13)30)36-26(43)18-7-12(29)9-38(18)20(40)10-39-17-8-19(27(31,32)33)44-23(17)22(37-39)25(35)42/h1-6,8,12,18H,7,9-10H2,(H2,34,41)(H2,35,42)(H,36,43)/t12-,18+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468638
PNG
((2S,4R)-N-(2'- chloro-2- fluorobiphenyl-3- yl)-1-(...)
Show SMILES F[C@@H]1C[C@H](N(C1)C(=O)Cc1cccc(Cl)c1)C(=O)Nc1cccc(c1F)-c1ccccc1Cl
Show InChI InChI=1S/C25H20Cl2F2N2O2/c26-16-6-3-5-15(11-16)12-23(32)31-14-17(28)13-22(31)25(33)30-21-10-4-8-19(24(21)29)18-7-1-2-9-20(18)27/h1-11,17,22H,12-14H2,(H,30,33)/t17-,22+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468643
PNG
(1-(2-((2S,4R)-2-(3- (7-chloro-1H- indazol-6-yl)-2-...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3cn[nH]c3c2Cl)c2ccccc12
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468646
PNG
(1-(2-((2S,4R)-2-(3- (7-chloro-1H- imidazo[4,5- b]p...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2cnc3nc[nH]c3c2Cl)c2ccccc12
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468659
PNG
((2S,4R)-1-(2-(3- carbamoyl-5- methoxyphenyl) acety...)
Show SMILES COc1cc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)cc(c1)C(N)=O
Show InChI InChI=1S/C27H24ClF2N3O4/c1-37-18-10-15(9-16(12-18)26(31)35)11-24(34)33-14-17(29)13-23(33)27(36)32-22-8-4-6-20(25(22)30)19-5-2-3-7-21(19)28/h2-10,12,17,23H,11,13-14H2,1H3,(H2,31,35)(H,32,36)/t17-,23+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468662
PNG
(1-(2-((2S,4R)-2-(2'- chloro-2- fluorobiphenyl-3- y...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)c2cn[nH]c12
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468673
PNG
(6-(3-((2S,4R)-1-(2- (3-acetyl-1H- indazol-1- yl)ac...)
Show SMILES CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2cc(C(O)=O)c3nc[nH]c3c2)c2ccccc12
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468686
PNG
(1-(2-((2S,4R)-4- fluoro-2-((2-fluoro- 3-(8-oxo-5,6...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3CCCC(=O)c3c2)c2ccccc12
Show InChI InChI=1S/C31H27F2N5O4/c32-19-14-25(37(15-19)27(40)16-38-24-9-2-1-6-21(24)29(36-38)30(34)41)31(42)35-23-8-4-7-20(28(23)33)18-12-11-17-5-3-10-26(39)22(17)13-18/h1-2,4,6-9,11-13,19,25H,3,5,10,14-16H2,(H2,34,41)(H,35,42)/t19-,25+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468584
PNG
(1-(2-((2S,4R)-4- fluoro-2-(2-fluoro- 3-(2-methyl-1...)
Show SMILES Cc1nc2cc(ccc2[nH]1)-c1cccc(NC(=O)[C@@H]2C[C@@H](F)CN2C(=O)Cn2nc(C(N)=O)c3ccccc23)c1F
PDB

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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468593
PNG
(1-(2-((2S,4R)-2-(3- (4-chloro-2-((S)-1- hydroxyeth...)
Show SMILES C[C@H](O)c1nc2c(Cl)c(ccc2[nH]1)-c1cccc(NC(=O)[C@@H]2C[C@@H](F)CN2C(=O)Cn2nc(C(N)=O)c3ccccc23)c1F
PDB

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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468615
PNG
(1-(2-((2S,4R)-2-(2'- chloro-2- fluorobiphenyl-3- y...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)c2cc(Cn3cc(nn3)C3CC3)sc12
Show InChI InChI=1S/C31H27ClF2N8O3S/c32-21-6-2-1-4-19(21)20-5-3-7-22(27(20)34)36-31(45)25-10-17(33)12-41(25)26(43)15-42-24-11-18(46-29(24)28(38-42)30(35)44)13-40-14-23(37-39-40)16-8-9-16/h1-7,11,14,16-17,25H,8-10,12-13,15H2,(H2,35,44)(H,36,45)/t17-,25+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468617
PNG
((2S,4R)-1-(2-(3- carbamoylphenyl) acetyl)-N-(2'-ch...)
Show SMILES NC(=O)c1cccc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)c1
Show InChI InChI=1S/C26H22ClF2N3O3/c27-20-9-2-1-7-18(20)19-8-4-10-21(24(19)29)31-26(35)22-13-17(28)14-32(22)23(33)12-15-5-3-6-16(11-15)25(30)34/h1-11,17,22H,12-14H2,(H2,30,34)(H,31,35)/t17-,22+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468639
PNG
((2S,4R)-N-(2'- chloro-2- fluorobiphenyl-3- yl)-4-f...)
Show SMILES COc1cccc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)c1
Show InChI InChI=1S/C26H23ClF2N2O3/c1-34-18-7-4-6-16(12-18)13-24(32)31-15-17(28)14-23(31)26(33)30-22-11-5-9-20(25(22)29)19-8-2-3-10-21(19)27/h2-12,17,23H,13-15H2,1H3,(H,30,33)/t17-,23+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468642
PNG
(1-(2-((2S,4R)-2-(3- (7-chloro-1H- benzo[d]imidazol...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(C(=O)Nc3nc4cccc(Cl)c4[nH]3)c2F)c2ccccc12
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468678
PNG
((2S,4R)-1-(2-(3- acetyl-1H-indazol- 1-yl)acetyl)-4...)
Show SMILES CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3[nH]ccc3c2)c2ccccc12
PDB

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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468682
PNG
(1-(2-((2S,4R)-2- ((2'-chloro-5'- (cyanocarbamoyl)-...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2cc(ccc2Cl)C(=O)NC#N)c2ccccc12
Show InChI InChI=1S/C29H22ClF2N7O4/c30-20-9-8-15(28(42)35-14-33)10-19(20)17-5-3-6-21(25(17)32)36-29(43)23-11-16(31)12-38(23)24(40)13-39-22-7-2-1-4-18(22)26(37-39)27(34)41/h1-10,16,23H,11-13H2,(H2,34,41)(H,35,42)(H,36,43)/t16-,23+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468683
PNG
(1-(2-((2S,4R)-2- ((3-(7-chloro-1H- indol-5-yl)-2- ...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2cc(Cl)c3[nH]ccc3c2)c2ccccc12
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468685
PNG
(1-(2-((2S,4R)-4- fluoro-2-((2-fluoro- 3-(2-oxo-2,3...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(-c3ccc4oc(=O)[nH]c4c3)c2F)c2ccccc12
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468694
PNG
((2S,4R)-1-(2-(3- acetyl-1H-indazol- 1-yl)acetyl)-N...)
Show SMILES CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(\C=C\c3nc4c(Cl)cccc4[nH]3)c2F)c2ccccc12
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468299
PNG
((2S,4R)-1-(2-(3- acetyl-1H- pyrazolo[3,4- e]pyridi...)
Show SMILES CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3[nH]cnc3c2Cl)c2cnccc12
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468616
PNG
(1-(2-((2S,4R)-2-(3- (4-chloro-1-methyl- 1H- benzo[...)
Show SMILES Cn1cnc2c(Cl)c(ccc12)-c1cccc(NC(=O)[C@@H]2C[C@@H](F)CN2C(=O)Cn2nc(C(N)=O)c3ccccc23)c1F
Show InChI InChI=1S/C29H24ClF2N7O3/c1-37-14-34-27-21(37)10-9-16(24(27)30)17-6-4-7-19(25(17)32)35-29(42)22-11-15(31)12-38(22)23(40)13-39-20-8-3-2-5-18(20)26(36-39)28(33)41/h2-10,14-15,22H,11-13H2,1H3,(H2,33,41)(H,35,42)/t15-,22+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468640
PNG
(1-(2-((2S,4R)-2-(3- (7-chloro-2-fluoro- 1H- benzo[...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3nc(F)[nH]c3c2Cl)c2ccccc12
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM386755
PNG
((2S,4R)-1-(2-(1- acetyl-6-(2- methylpyrimidin- 5-y...)
Show SMILES CC(=O)n1cc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)c2ccc(cc12)-c1cnc(C)nc1
Show InChI InChI=1S/C34H28ClF2N5O3/c1-19-38-15-23(16-39-19)21-10-11-25-22(17-41(20(2)43)30(25)12-21)13-32(44)42-18-24(36)14-31(42)34(45)40-29-9-5-7-27(33(29)37)26-6-3-4-8-28(26)35/h3-12,15-17,24,31H,13-14,18H2,1-2H3,(H,40,45)/t24-,31+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM386756
PNG
((2S,4R)-1-(2-(1- acetyl-6-(2- methylpyrimidin- 5-y...)
Show SMILES CC(=O)n1cc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(Br)n2)c2ccc(cc12)-c1cnc(C)nc1
Show InChI InChI=1S/C27H24BrFN6O3/c1-15-30-11-19(12-31-15)17-6-7-21-18(13-34(16(2)36)22(21)8-17)9-26(37)35-14-20(29)10-23(35)27(38)33-25-5-3-4-24(28)32-25/h3-8,11-13,20,23H,9-10,14H2,1-2H3,(H,32,33,38)/t20-,23+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468658
PNG
(6-(3-((2S,4R)-1-(2- (3-carbamoyl-1H- indazol-1- yl...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3nc([nH]c3c2Cl)C(O)=O)c2ccccc12
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468680
PNG
(1-(2-((2S,4R)-4- fluoro-2-((2-fluoro- 3-(3-oxo-2,3...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(-c3ccc4CCC(=O)c4c3)c2F)c2ccccc12
Show InChI InChI=1S/C30H25F2N5O4/c31-18-13-24(36(14-18)26(39)15-37-23-7-2-1-4-20(23)28(35-37)29(33)40)30(41)34-22-6-3-5-19(27(22)32)17-9-8-16-10-11-25(38)21(16)12-17/h1-9,12,18,24H,10-11,13-15H2,(H2,33,40)(H,34,41)/t18-,24+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468691
PNG
((2S,4R)-1-(2-(3- acetyl-1H-indazol- 1-yl)acetyl)-N...)
Show SMILES CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(-c3ccc4nc(N)sc4c3)c2F)c2ccccc12
Show InChI InChI=1S/C29H24F2N6O3S/c1-15(38)27-19-5-2-3-8-22(19)37(35-27)14-25(39)36-13-17(30)12-23(36)28(40)33-21-7-4-6-18(26(21)31)16-9-10-20-24(11-16)41-29(32)34-20/h2-11,17,23H,12-14H2,1H3,(H2,32,34)(H,33,40)/t17-,23+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468692
PNG
((2S,4R)-1-(2-(3- acetyl-1H-indazol- 1-yl)acetyl)-N...)
Show SMILES CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(-c3ccc4[nH]c(=O)[nH]c(=O)c4c3)c2F)c2ccccc12
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468627
PNG
(2-(3-acetyl-6-(3- ((2S,4R)-1-(2-(3- carbamoyl-1H- ...)
Show SMILES CC(=O)c1cn(CC(O)=O)c2cc(ccc12)-c1cccc(NC(=O)[C@@H]2C[C@@H](F)CN2C(=O)Cn2nc(C(N)=O)c3ccccc23)c1F
Show InChI InChI=1S/C33H28F2N6O6/c1-17(42)23-14-39(16-29(44)45)26-11-18(9-10-21(23)26)20-6-4-7-24(30(20)35)37-33(47)27-12-19(34)13-40(27)28(43)15-41-25-8-3-2-5-22(25)31(38-41)32(36)46/h2-11,14,19,27H,12-13,15-16H2,1H3,(H2,36,46)(H,37,47)(H,44,45)/t19-,27+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468596
PNG
((2S,3R)-2-(2-(3- acetyl-1H-indol-1- yl)acetamido)-...)
Show SMILES C[C@@H](O)[C@H](NC(=O)Cn1cc(C(C)=O)c2ccccc12)C(=O)Nc1cccc(Br)n1
Show InChI InChI=1S/C21H21BrN4O4/c1-12(27)15-10-26(16-7-4-3-6-14(15)16)11-19(29)25-20(13(2)28)21(30)24-18-9-5-8-17(22)23-18/h3-10,13,20,28H,11H2,1-2H3,(H,25,29)(H,23,24,30)/t13-,20+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468654
PNG
(5-(2-((2S,4R)-2-(2'- chloro-2- fluorobiphenyl-3- y...)
Show SMILES NC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)n2ccnc12
Show InChI InChI=1S/C25H21ClF2N6O3/c26-18-6-2-1-4-15(18)16-5-3-7-19(22(16)28)31-25(37)20-10-14(27)11-33(20)21(35)13-32-12-17(23(29)36)24-30-8-9-34(24)32/h1-9,12,14,20H,10-11,13H2,(H2,29,36)(H,31,37)/t14-,20+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468677
PNG
((2S,4R)-1-(2-(3- acetyl-1H-indazol- 1-yl)acetyl)-N...)
Show SMILES CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3ncn(CCN)c3c2Cl)c2ccccc12
Show InChI InChI=1S/C31H28ClF2N7O3/c1-17(42)29-21-5-2-3-8-24(21)41(38-29)15-26(43)40-14-18(33)13-25(40)31(44)37-22-7-4-6-20(28(22)34)19-9-10-23-30(27(19)32)39(12-11-35)16-36-23/h2-10,16,18,25H,11-15,35H2,1H3,(H,37,44)/t18-,25+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468618
PNG
((2S,4R)-1-(2-(3- carbamoyl-4- chlorophenyl)acetyl)...)
Show SMILES NC(=O)c1cc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)ccc1Cl
Show InChI InChI=1S/C26H21Cl2F2N3O3/c27-19-6-2-1-4-16(19)17-5-3-7-21(24(17)30)32-26(36)22-12-15(29)13-33(22)23(34)11-14-8-9-20(28)18(10-14)25(31)35/h1-10,15,22H,11-13H2,(H2,31,35)(H,32,36)/t15-,22+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468594
PNG
((2S,3R)-2-(2-(3- acetyl-1H-indol-1- yl)-N- methyla...)
Show SMILES C[C@@H](O)[C@H](N(C)C(=O)Cn1cc(C(C)=O)c2ccccc12)C(=O)Nc1cccc(c1F)-c1ccccc1Cl
Show InChI InChI=1S/C29H27ClFN3O4/c1-17(35)22-15-34(25-14-7-5-10-20(22)25)16-26(37)33(3)28(18(2)36)29(38)32-24-13-8-11-21(27(24)31)19-9-4-6-12-23(19)30/h4-15,18,28,36H,16H2,1-3H3,(H,32,38)/t18-,28+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468637
PNG
((2S,4R)-1-(2-(6- bromopyridin-2- yl)acetyl)-N-(2'-...)
Show SMILES F[C@@H]1C[C@H](N(C1)C(=O)Cc1cccc(Br)n1)C(=O)Nc1cccc(c1F)-c1ccccc1Cl
Show InChI InChI=1S/C24H19BrClF2N3O2/c25-21-10-3-5-15(29-21)12-22(32)31-13-14(27)11-20(31)24(33)30-19-9-4-7-17(23(19)28)16-6-1-2-8-18(16)26/h1-10,14,20H,11-13H2,(H,30,33)/t14-,20+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468671
PNG
(2-amino-6-(3- ((2S,4R)-1-(2-(3- carbamoyl-1H- inda...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(-c3cc(C(O)=O)c4nc(N)[nH]c4c3)c2F)c2ccccc12
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468619
PNG
((2S,4R)-N-(2'- chloro-2- fluorobiphenyl-3- yl)-1-(...)
Show SMILES F[C@@H]1C[C@H](N(C1)C(=O)Cc1ccc(Cl)c(c1)C#N)C(=O)Nc1cccc(c1F)-c1ccccc1Cl
Show InChI InChI=1S/C26H19Cl2F2N3O2/c27-20-9-8-15(10-16(20)13-31)11-24(34)33-14-17(29)12-23(33)26(35)32-22-7-3-5-19(25(22)30)18-4-1-2-6-21(18)28/h1-10,17,23H,11-12,14H2,(H,32,35)/t17-,23+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468626
PNG
(US10807952, Cmp No. 30 | tert-butyl 2-(3- acetyl-6...)
Show SMILES CC(=O)c1cn(CC(=O)OC(C)(C)C)c2cc(ccc12)-c1cccc(NC(=O)[C@@H]2C[C@@H](F)CN2C(=O)Cn2nc(C(N)=O)c3ccccc23)c1F
Show InChI InChI=1S/C37H36F2N6O6/c1-20(46)26-17-43(19-32(48)51-37(2,3)4)29-14-21(12-13-24(26)29)23-9-7-10-27(33(23)39)41-36(50)30-15-22(38)16-44(30)31(47)18-45-28-11-6-5-8-25(28)34(42-45)35(40)49/h5-14,17,22,30H,15-16,18-19H2,1-4H3,(H2,40,49)(H,41,50)/t22-,30+/m1/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468660
PNG
(US10807952, Cmp No. 64 | tert-butyl ((3'- ((2S,4R)...)
Show SMILES CC(C)(C)OC(=O)N=S(C)(=O)c1cccc(c1)-c1cccc(NC(=O)[C@@H]2C[C@@H](F)CN2C(=O)Cn2nc(C(N)=O)c3ccccc23)c1F
Show InChI InChI=1S/C33H34F2N6O6S/c1-33(2,3)47-32(45)39-48(4,46)21-10-7-9-19(15-21)22-12-8-13-24(28(22)35)37-31(44)26-16-20(34)17-40(26)27(42)18-41-25-14-6-5-11-23(25)29(38-41)30(36)43/h5-15,20,26H,16-18H2,1-4H3,(H2,36,43)(H,37,44)/t20-,26+,48?/m1/s1
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n/an/a 5.50E+3n/an/an/an/an/an/a



Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468661
PNG
(1-(2-((2S,4R)-4- fluoro-2-(2-fluoro- 3'-(S- methyl...)
Show SMILES CS(=N)(=O)c1cccc(c1)-c1cccc(NC(=O)[C@@H]2C[C@@H](F)CN2C(=O)Cn2nc(C(N)=O)c3ccccc23)c1F
Show InChI InChI=1S/C28H26F2N6O4S/c1-41(32,40)18-7-4-6-16(12-18)19-9-5-10-21(25(19)30)33-28(39)23-13-17(29)14-35(23)24(37)15-36-22-11-3-2-8-20(22)26(34-36)27(31)38/h2-12,17,23,32H,13-15H2,1H3,(H2,31,38)(H,33,39)/t17-,23+,41?/m1/s1
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n/an/a 5.50E+3n/an/an/an/an/an/a



Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468696
PNG
(4-bromo-1-(2- ((2S,4R)-2-((6- bromopyridin-2- yl)c...)
Show SMILES Cc1c(Br)c(nn1CC(=O)N1C[C@H](F)C[C@H]1C(=O)Nc1cccc(Br)n1)C(N)=O
Show InChI InChI=1S/C17H17Br2FN6O3/c1-8-14(19)15(16(21)28)24-26(8)7-13(27)25-6-9(20)5-10(25)17(29)23-12-4-2-3-11(18)22-12/h2-4,9-10H,5-7H2,1H3,(H2,21,28)(H,22,23,29)/t9-,10+/m1/s1
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n/an/a 5.50E+3n/an/an/an/an/an/a



Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468697
PNG
((2S,4R)-1-(2-(3- acetyl-1H-pyrrol-1- yl)acetyl)-N-...)
Show SMILES CC(=O)c1ccn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(Br)n2)c1
Show InChI InChI=1S/C18H18BrFN4O3/c1-11(25)12-5-6-23(8-12)10-17(26)24-9-13(20)7-14(24)18(27)22-16-4-2-3-15(19)21-16/h2-6,8,13-14H,7,9-10H2,1H3,(H,21,22,27)/t13-,14+/m1/s1
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n/an/a 5.50E+3n/an/an/an/an/an/a



Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468669
PNG
(US10807952, Cmp No. 75 | methyl 2-((tert- butoxyca...)
Show SMILES COC(=O)c1cc(cc2[nH]c(NC(=O)OC(C)(C)C)nc12)-c1cccc(NC(=O)[C@@H]2C[C@@H](F)CN2C(=O)Cn2nc(C(N)=O)c3ccccc23)c1F
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n/an/a>1.00E+4n/an/an/an/an/an/a



Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468632
PNG
(2-(2-(3-acetyl-1H- indol-1- yl)acetamido)-N- (2'-c...)
Show SMILES CC(=O)c1cn(CC(=O)NC(CC(F)(F)F)C(=O)Nc2cccc(c2F)-c2ccccc2Cl)c2ccccc12
Show InChI InChI=1S/C28H22ClF4N3O3/c1-16(37)20-14-36(24-12-5-3-8-18(20)24)15-25(38)34-23(13-28(31,32)33)27(39)35-22-11-6-9-19(26(22)30)17-7-2-4-10-21(17)29/h2-12,14,23H,13,15H2,1H3,(H,34,38)(H,35,39)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468651
PNG
(5-(2-((2S,4R)-2-(6- bromopyridin-2- ylcarbamoyl)-4...)
Show SMILES NC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(Br)n2)n2ccnc12
Show InChI InChI=1S/C18H17BrFN7O3/c19-13-2-1-3-14(23-13)24-18(30)12-6-10(20)7-26(12)15(28)9-25-8-11(16(21)29)17-22-4-5-27(17)25/h1-5,8,10,12H,6-7,9H2,(H2,21,29)(H,23,24,30)/t10-,12+/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468679
PNG
((1R,3S,5R)-2-(2-(3- acetyl-1H-indazol- 1-yl)acetyl...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)Nc2cccc(c2F)-c2cc(Cl)c3[nH]ccc3c2)c2ccccc12
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n/an/a>1.00E+4n/an/an/an/an/an/a



Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468695
PNG
(5-(cyclohex-1-en-1- yl)-1-(2-((2S)-5- fluoro-2-((6...)
Show SMILES Cc1cccc(NC(=O)[C@@H]2CCC(F)CCN2C(=O)Cn2cc(C(N)=O)c3cc(ccc23)C2=CCCCC2)n1
Show InChI InChI=1S/C30H34FN5O3/c1-19-6-5-9-27(33-19)34-30(39)26-13-11-22(31)14-15-36(26)28(37)18-35-17-24(29(32)38)23-16-21(10-12-25(23)35)20-7-3-2-4-8-20/h5-7,9-10,12,16-17,22,26H,2-4,8,11,13-15,18H2,1H3,(H2,32,38)(H,33,34,39)/t22?,26-/m0/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM468650
PNG
((S)-5-(2-(2-(2'- chloro-2- fluorobiphenyl-3- ylcar...)
Show SMILES NC(=O)c1cn(CC(=O)N2CCC[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)n2ccnc12
Show InChI InChI=1S/C25H22ClFN6O3/c26-18-7-2-1-5-15(18)16-6-3-8-19(22(16)27)30-25(36)20-9-4-11-32(20)21(34)14-31-13-17(23(28)35)24-29-10-12-33(24)31/h1-3,5-8,10,12-13,20H,4,9,11,14H2,(H2,28,35)(H,30,36)/t20-/m0/s1
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Achillion Pharmaceuticals, Inc.

US Patent


Assay Description
TBD


US Patent US10807952 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%