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Patent code US10807974

Compile Data Set for Download or QSAR

Found 309 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50526723
PNG
(CHEMBL4515085 | US10807974, Example 121)
Show SMILES Cc1ccc(cc1)-c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)S(C)(=O)=O
Show InChI InChI=1S/C18H18N2O4S3/c1-12-3-5-13(6-4-12)14-7-15(26(2,21)22)9-16(8-14)27(23,24)18-11-20-17(10-19)25-18/h3-9,11H,10,19H2,1-2H3
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n/an/a 28n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469087
PNG
(US10807974, Example 106)
Show SMILES CCc1cc(CC)cc(c1)S(=O)(=O)c1cnc(CN)s1
Show InChI InChI=1S/C14H18N2O2S2/c1-3-10-5-11(4-2)7-12(6-10)20(17,18)14-9-16-13(8-15)19-14/h5-7,9H,3-4,8,15H2,1-2H3
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n/an/a 45n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469088
PNG
(US10807974, Example 107)
Show SMILES CCc1cccc(c1)S(=O)(=O)c1cnc(CN)s1
Show InChI InChI=1S/C12H14N2O2S2/c1-2-9-4-3-5-10(6-9)18(15,16)12-8-14-11(7-13)17-12/h3-6,8H,2,7,13H2,1H3
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n/an/a 56n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469029
PNG
(US10807974, Example 14 | US10807974, Example 42)
Show SMILES NCc1ccc(s1)S(=O)(=O)c1cccc(c1)S(=O)(=O)N1CCCC1
Show InChI InChI=1S/C15H18N2O4S3/c16-11-12-6-7-15(22-12)23(18,19)13-4-3-5-14(10-13)24(20,21)17-8-1-2-9-17/h3-7,10H,1-2,8-9,11,16H2
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n/an/a 56n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50526725
PNG
(CHEMBL4450748 | US10807974, Example 122)
Show SMILES CNc1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccccc1
Show InChI InChI=1S/C17H17N3O2S2/c1-19-14-7-13(12-5-3-2-4-6-12)8-15(9-14)24(21,22)17-11-20-16(10-18)23-17/h2-9,11,19H,10,18H2,1H3
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n/an/a 58n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50526740
PNG
(CHEMBL4447452 | US10807974, Example 108)
Show SMILES NCc1ncc(s1)S(=O)(=O)c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C16H14N2O2S2/c17-10-15-18-11-16(21-15)22(19,20)14-8-4-7-13(9-14)12-5-2-1-3-6-12/h1-9,11H,10,17H2
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n/an/a 60n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469139
PNG
(US10807974, Example 158)
Show SMILES Cc1ccc(cn1)-c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)C(O)=O
Show InChI InChI=1S/C17H15N3O4S2/c1-10-2-3-11(8-19-10)12-4-13(17(21)22)6-14(5-12)26(23,24)16-9-20-15(7-18)25-16/h2-6,8-9H,7,18H2,1H3,(H,21,22)
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n/an/a 64n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 1 hour at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50526731
PNG
(CHEMBL4564074 | US10807974, Example 103)
Show SMILES CCc1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccccc1
Show InChI InChI=1S/C18H18N2O2S2/c1-2-13-8-15(14-6-4-3-5-7-14)10-16(9-13)24(21,22)18-12-20-17(11-19)23-18/h3-10,12H,2,11,19H2,1H3
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n/an/a 65n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469115
PNG
(US10807974, Example 134)
Show SMILES CS(=O)(=O)c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1cccc(F)c1
Show InChI InChI=1S/C17H15FN2O4S3/c1-26(21,22)14-6-12(11-3-2-4-13(18)5-11)7-15(8-14)27(23,24)17-10-20-16(9-19)25-17/h2-8,10H,9,19H2,1H3
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n/an/a 66n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 1 hour at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469080
PNG
(US10807974, Example 99)
Show SMILES NCc1ncc(s1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C14H12N2O2S2/c15-8-13-16-9-14(19-13)20(17,18)12-7-3-5-10-4-1-2-6-11(10)12/h1-7,9H,8,15H2
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n/an/a 68n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469094
PNG
(US10807974, Example 113)
Show SMILES CCc1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccc[n+]([O-])c1
Show InChI InChI=1S/C17H17N3O3S2/c1-2-12-6-14(13-4-3-5-20(21)11-13)8-15(7-12)25(22,23)17-10-19-16(9-18)24-17/h3-8,10-11H,2,9,18H2,1H3
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n/an/a 70n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469070
PNG
(US10807974, Example 91)
Show SMILES Cc1ccc(cc1)-c1cccc(c1)S(=O)(=O)c1cnc(CN)s1
Show InChI InChI=1S/C17H16N2O2S2/c1-12-5-7-13(8-6-12)14-3-2-4-15(9-14)23(20,21)17-11-19-16(10-18)22-17/h2-9,11H,10,18H2,1H3
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The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469122
PNG
((5-((3-Methoxy-5-(1-(methoxymethyl)-1H-pyrazol-4-y...)
Show SMILES COCn1cc(cn1)-c1cc(OC)cc(c1)S(=O)(=O)c1cnc(CN)s1
Show InChI InChI=1S/C16H18N4O4S2/c1-23-10-20-9-12(7-19-20)11-3-13(24-2)5-14(4-11)26(21,22)16-8-18-15(6-17)25-16/h3-5,7-9H,6,10,17H2,1-2H3
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n/an/a 72n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 1 hour at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469113
PNG
(US10807974, Example 132)
Show SMILES COc1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1cnn(c1)C1CC1
Show InChI InChI=1S/C17H18N4O3S2/c1-24-14-4-11(12-8-20-21(10-12)13-2-3-13)5-15(6-14)26(22,23)17-9-19-16(7-18)25-17/h4-6,8-10,13H,2-3,7,18H2,1H3
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n/an/a 74n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 1 hour at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469097
PNG
(US10807974, Example 116)
Show SMILES Cn1cc(cn1)-c1cccc(c1)S(=O)(=O)c1cnc(CN)s1
Show InChI InChI=1S/C14H14N4O2S2/c1-18-9-11(7-17-18)10-3-2-4-12(5-10)22(19,20)14-8-16-13(6-15)21-14/h2-5,7-9H,6,15H2,1H3
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n/an/a 74n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469085
PNG
(US10807974, Example 104)
Show SMILES CCc1ccccc1S(=O)(=O)c1cnc(CN)s1
Show InChI InChI=1S/C12H14N2O2S2/c1-2-9-5-3-4-6-10(9)18(15,16)12-8-14-11(7-13)17-12/h3-6,8H,2,7,13H2,1H3
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n/an/a 74n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469132
PNG
(US10807974, Example 151)
Show SMILES CCNC(=O)c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccccc1
Show InChI InChI=1S/C19H19N3O3S2/c1-2-21-19(23)15-8-14(13-6-4-3-5-7-13)9-16(10-15)27(24,25)18-12-22-17(11-20)26-18/h3-10,12H,2,11,20H2,1H3,(H,21,23)
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n/an/a 77n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 1 hour at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469118
PNG
(US10807974, Example 137)
Show SMILES Cn1cnc(c1)-c1cc(cc(c1)S(=O)(=O)c1ccc(CN)s1)S(C)(=O)=O
Show InChI InChI=1S/C16H17N3O4S3/c1-19-9-15(18-10-19)11-5-13(25(2,20)21)7-14(6-11)26(22,23)16-4-3-12(8-17)24-16/h3-7,9-10H,8,17H2,1-2H3
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n/an/a 79n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 1 hour at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50526755
PNG
(CHEMBL4470882 | US10807974, Example 109)
Show SMILES CC(C)c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccccc1
Show InChI InChI=1S/C19H20N2O2S2/c1-13(2)15-8-16(14-6-4-3-5-7-14)10-17(9-15)25(22,23)19-12-21-18(11-20)24-19/h3-10,12-13H,11,20H2,1-2H3
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n/an/a 82n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469109
PNG
(US10807974, Example 128)
Show SMILES COc1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1cnn(C)c1
Show InChI InChI=1S/C15H16N4O3S2/c1-19-9-11(7-18-19)10-3-12(22-2)5-13(4-10)24(20,21)15-8-17-14(6-16)23-15/h3-5,7-9H,6,16H2,1-2H3
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n/an/a 82n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 1 hour at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50526732
PNG
(CHEMBL4460845 | US10807974, Example 131)
Show SMILES Cn1cc(cn1)-c1cc(F)cc(c1)S(=O)(=O)c1cnc(CN)s1
Show InChI InChI=1S/C14H13FN4O2S2/c1-19-8-10(6-18-19)9-2-11(15)4-12(3-9)23(20,21)14-7-17-13(5-16)22-14/h2-4,6-8H,5,16H2,1H3
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n/an/a 85n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 1 hour at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469117
PNG
(US10807974, Example 136)
Show SMILES Cn1cc(cn1)-c1cc(ccc1S(C)(=O)=O)S(=O)(=O)c1cnc(CN)s1
Show InChI InChI=1S/C15H16N4O4S3/c1-19-9-10(7-18-19)12-5-11(3-4-13(12)25(2,20)21)26(22,23)15-8-17-14(6-16)24-15/h3-5,7-9H,6,16H2,1-2H3
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n/an/a 89n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 1 hour at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50526748
PNG
(CHEMBL4443558 | US10807974, Example 90)
Show SMILES NCc1ccc(s1)S(=O)(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C15H13NO2S2/c16-10-13-6-8-15(19-13)20(17,18)14-7-5-11-3-1-2-4-12(11)9-14/h1-9H,10,16H2
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n/an/a 90n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50526727
PNG
(CHEMBL4568508 | US10807974, Example 100)
Show SMILES CS(=O)(=O)c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccccc1
Show InChI InChI=1S/C17H16N2O4S3/c1-25(20,21)14-7-13(12-5-3-2-4-6-12)8-15(9-14)26(22,23)17-11-19-16(10-18)24-17/h2-9,11H,10,18H2,1H3
PDB

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n/an/a 90n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469111
PNG
(US10807974, Example 130)
Show SMILES CCn1cc(cn1)-c1cc(OC)cc(c1)S(=O)(=O)c1cnc(CN)s1
Show InChI InChI=1S/C16H18N4O3S2/c1-3-20-10-12(8-19-20)11-4-13(23-2)6-14(5-11)25(21,22)16-9-18-15(7-17)24-16/h4-6,8-10H,3,7,17H2,1-2H3
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n/an/a 94n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 1 hour at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469116
PNG
(US10807974, Example 135)
Show SMILES COc1ccc(cc1-c1cnn(C)c1)S(=O)(=O)c1cnc(CN)s1
Show InChI InChI=1S/C15H16N4O3S2/c1-19-9-10(7-18-19)12-5-11(3-4-13(12)22-2)24(20,21)15-8-17-14(6-16)23-15/h3-5,7-9H,6,16H2,1-2H3
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n/an/a 96n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 1 hour at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469082
PNG
(US10807974, Example 101)
Show SMILES NCc1ncc(s1)S(=O)(=O)c1ccc2CCCCc2c1
Show InChI InChI=1S/C14H16N2O2S2/c15-8-13-16-9-14(19-13)20(17,18)12-6-5-10-3-1-2-4-11(10)7-12/h5-7,9H,1-4,8,15H2
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n/an/a 100n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50526745
PNG
(CHEMBL4462499 | US10807974, Example 105)
Show SMILES COc1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccccc1
Show InChI InChI=1S/C17H16N2O3S2/c1-22-14-7-13(12-5-3-2-4-6-12)8-15(9-14)24(20,21)17-11-19-16(10-18)23-17/h2-9,11H,10,18H2,1H3
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n/an/a 110n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469099
PNG
(US10807974, Example 118)
Show SMILES NCc1ncc(s1)S(=O)(=O)c1cnc(nc1)-c1ccccc1
Show InChI InChI=1S/C14H12N4O2S2/c15-6-12-16-9-13(21-12)22(19,20)11-7-17-14(18-8-11)10-4-2-1-3-5-10/h1-5,7-9H,6,15H2
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n/an/a 110n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469105
PNG
(US10807974, Example 124)
Show SMILES NCc1ccc(s1)S(=O)(=O)c1cccc(c1)S(=O)(=O)N1CCCC1c1ccccc1
Show InChI InChI=1S/C21H22N2O4S3/c22-15-17-11-12-21(28-17)29(24,25)18-8-4-9-19(14-18)30(26,27)23-13-5-10-20(23)16-6-2-1-3-7-16/h1-4,6-9,11-12,14,20H,5,10,13,15,22H2
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n/an/a 120n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 1 hour at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50526721
PNG
(CHEMBL4444163 | US10807974, Example 111)
Show SMILES CCc1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1cnn(C)c1
Show InChI InChI=1S/C16H18N4O2S2/c1-3-11-4-12(13-8-19-20(2)10-13)6-14(5-11)24(21,22)16-9-18-15(7-17)23-16/h4-6,8-10H,3,7,17H2,1-2H3
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n/an/a 130n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50526751
PNG
(CHEMBL4545533 | US10807974, Example 133)
Show SMILES CS(=O)(=O)c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccc(F)cc1
Show InChI InChI=1S/C17H15FN2O4S3/c1-26(21,22)14-6-12(11-2-4-13(18)5-3-11)7-15(8-14)27(23,24)17-10-20-16(9-19)25-17/h2-8,10H,9,19H2,1H3
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n/an/a 140n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 1 hour at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469120
PNG
(US10807974, Example 139)
Show SMILES COc1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1cn(C)cn1
Show InChI InChI=1S/C15H16N4O3S2/c1-19-8-13(18-9-19)10-3-11(22-2)5-12(4-10)24(20,21)15-7-17-14(6-16)23-15/h3-5,7-9H,6,16H2,1-2H3
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n/an/a 140n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 1 hour at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469096
PNG
(US10807974, Example 115)
Show SMILES CCc1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccsc1
Show InChI InChI=1S/C16H16N2O2S3/c1-2-11-5-13(12-3-4-21-10-12)7-14(6-11)23(19,20)16-9-18-15(8-17)22-16/h3-7,9-10H,2,8,17H2,1H3
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n/an/a 140n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469094
PNG
(US10807974, Example 113)
Show SMILES CCc1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccc[n+]([O-])c1
Show InChI InChI=1S/C17H17N3O3S2/c1-2-12-6-14(13-4-3-5-20(21)11-13)8-15(7-12)25(22,23)17-10-19-16(9-18)24-17/h3-8,10-11H,2,9,18H2,1H3
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n/an/a 150n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 1 hour at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469093
PNG
(US10807974, Example 112)
Show SMILES CCc1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1c(C)noc1C
Show InChI InChI=1S/C17H19N3O3S2/c1-4-12-5-13(17-10(2)20-23-11(17)3)7-14(6-12)25(21,22)16-9-19-15(8-18)24-16/h5-7,9H,4,8,18H2,1-3H3
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n/an/a 150n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469135
PNG
(US10807974, Example 154)
Show SMILES CCNC(=O)c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1cnn(C)c1
Show InChI InChI=1S/C17H19N5O3S2/c1-3-19-17(23)12-4-11(13-8-21-22(2)10-13)5-14(6-12)27(24,25)16-9-20-15(7-18)26-16/h4-6,8-10H,3,7,18H2,1-2H3,(H,19,23)
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n/an/a 150n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 1 hour at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50526744
PNG
(CHEMBL4475714 | US10807974, Example 114)
Show SMILES CC(C)(C)c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccccc1
Show InChI InChI=1S/C20H22N2O2S2/c1-20(2,3)16-9-15(14-7-5-4-6-8-14)10-17(11-16)26(23,24)19-13-22-18(12-21)25-19/h4-11,13H,12,21H2,1-3H3
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n/an/a 170n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50526750
PNG
(CHEMBL4468424 | US10807974, Example 140)
Show SMILES CS(=O)(=O)c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C18H15F3N2O4S3/c1-29(24,25)14-6-12(11-2-4-13(5-3-11)18(19,20)21)7-15(8-14)30(26,27)17-10-23-16(9-22)28-17/h2-8,10H,9,22H2,1H3
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n/an/a 170n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 1 hour at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469134
PNG
(US10807974, Example 153)
Show SMILES CC(C)NC(=O)c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1cnn(C)c1
Show InChI InChI=1S/C18H21N5O3S2/c1-11(2)22-18(24)13-4-12(14-8-21-23(3)10-14)5-15(6-13)28(25,26)17-9-20-16(7-19)27-17/h4-6,8-11H,7,19H2,1-3H3,(H,22,24)
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n/an/a 170n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 1 hour at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Protein-lysine 6-oxidase


(Mus musculus)
BDBM50526737
PNG
(CHEMBL4528500 | US10807974, Example 82)
Show SMILES Cc1ccc(cc1)-c1cc(ccc1S(C)(=O)=O)S(=O)(=O)c1ccc(CN)s1
Show InChI InChI=1S/C19H19NO4S3/c1-13-3-5-14(6-4-13)17-11-16(8-9-18(17)26(2,21)22)27(23,24)19-10-7-15(12-20)25-19/h3-11H,12,20H2,1-2H3
KEGG

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n/an/a<180n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
To produce MDCK cysts, cells were cultured on Matrigel (Corning) with 2% Matrigel supplemented in DMEM with 10% FBS. Cysts were allowed to form for 1...


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469106
PNG
(US10807974, Example 125)
Show SMILES CN(C)C(=O)c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccccc1
Show InChI InChI=1S/C19H19N3O3S2/c1-22(2)19(23)15-8-14(13-6-4-3-5-7-13)9-16(10-15)27(24,25)18-12-21-17(11-20)26-18/h3-10,12H,11,20H2,1-2H3
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n/an/a 180n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 1 hour at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469108
PNG
(US10807974, Example 127)
Show SMILES CS(=O)(=O)c1cc(cc(c1)S(=O)(=O)c1ccc(CN)s1)-c1cn[nH]c1
Show InChI InChI=1S/C15H15N3O4S3/c1-24(19,20)13-4-10(11-8-17-18-9-11)5-14(6-13)25(21,22)15-3-2-12(7-16)23-15/h2-6,8-9H,7,16H2,1H3,(H,17,18)
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n/an/a 180n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 1 hour at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50501883
PNG
(CHEMBL4564517 | US10807974, Example 76)
Show SMILES Cc1ccc(cc1)-c1cc(cc(c1)S(=O)(=O)c1ccc(CN)s1)S(C)(=O)=O
Show InChI InChI=1S/C19H19NO4S3/c1-13-3-5-14(6-4-13)15-9-17(26(2,21)22)11-18(10-15)27(23,24)19-8-7-16(12-20)25-19/h3-11H,12,20H2,1-2H3
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n/an/a 190n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Protein-lysine 6-oxidase


(Mus musculus)
BDBM50526721
PNG
(CHEMBL4444163 | US10807974, Example 111)
Show SMILES CCc1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1cnn(C)c1
Show InChI InChI=1S/C16H18N4O2S2/c1-3-11-4-12(13-8-19-20(2)10-13)6-14(5-11)24(21,22)16-9-18-15(7-17)23-16/h4-6,8-10H,3,7,17H2,1-2H3
KEGG

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n/an/a 190n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
To produce MDCK cysts, cells were cultured on Matrigel (Corning) with 2% Matrigel supplemented in DMEM with 10% FBS. Cysts were allowed to form for 1...


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469077
PNG
(US10807974, Example 96)
Show SMILES NCCS(=O)(=O)c1cnc(CN)s1
Show InChI InChI=1S/C6H11N3O2S2/c7-1-2-13(10,11)6-4-9-5(3-8)12-6/h4H,1-3,7-8H2
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n/an/a 200n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469078
PNG
(US10807974, Example 97)
Show SMILES NCc1ncc(s1)S(=O)(=O)c1cc2ccccc2c2ccccc12
Show InChI InChI=1S/C18H14N2O2S2/c19-10-17-20-11-18(23-17)24(21,22)16-9-12-5-1-2-6-13(12)14-7-3-4-8-15(14)16/h1-9,11H,10,19H2
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n/an/a 200n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50526748
PNG
(CHEMBL4443558 | US10807974, Example 90)
Show SMILES NCc1ccc(s1)S(=O)(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C15H13NO2S2/c16-10-13-6-8-15(19-13)20(17,18)14-7-5-11-3-1-2-4-12(11)9-14/h1-9H,10,16H2
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n/an/a 200n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469137
PNG
(US10807974, Example 156)
Show SMILES Cn1cc(cn1)-c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)C(=O)N1CC[C@@H](O)C1
Show InChI InChI=1S/C19H21N5O4S2/c1-23-10-14(8-22-23)12-4-13(19(26)24-3-2-15(25)11-24)6-16(5-12)30(27,28)18-9-21-17(7-20)29-18/h4-6,8-10,15,25H,2-3,7,11,20H2,1H3/t15-/m1/s1
PDB

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UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 200n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 1 hour at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM469125
PNG
(US10807974, Example 144)
Show SMILES CS(=O)(=O)c1ccc(c(c1)-c1ccccc1)S(=O)(=O)c1cnc(CN)s1
Show InChI InChI=1S/C17H16N2O4S3/c1-25(20,21)13-7-8-15(14(9-13)12-5-3-2-4-6-12)26(22,23)17-11-19-16(10-18)24-17/h2-9,11H,10,18H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 220n/an/an/an/an/an/a



The Institute of Cancer Research: Royal Cancer Hospital

US Patent


Assay Description
LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 1 hour at room temp on a plate shaker.


US Patent US10807974 (2020)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%