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Patent code US10807985

Compile Data Set for Download or QSAR
Found 169 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469251
PNG
(US10807985, Compound 26)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cn[nH]c1
PDB

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PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469259
PNG
(US10807985, Compound 34)
Show SMILES C[C@](N)(c1ccccc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C28H27FN8/c1-28(30,22-5-3-2-4-6-22)23-16-31-27(32-17-23)36-13-11-35(12-14-36)26-25-15-21(18-37(25)34-19-33-26)20-7-9-24(29)10-8-20/h2-10,15-19H,11-14,30H2,1H3/t28-/m0/s1
PDB

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UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469269
PNG
(US10807985, Compound 44)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1
Show InChI InChI=1S/C26H27FN10/c1-26(28,20-3-5-22(27)6-4-20)21-13-29-25(30-14-21)36-9-7-35(8-10-36)24-23-11-18(16-37(23)33-17-31-24)19-12-32-34(2)15-19/h3-6,11-17H,7-10,28H2,1-2H3/t26-/m0/s1
PDB

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UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469269
PNG
(US10807985, Compound 44)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1
Show InChI InChI=1S/C26H27FN10/c1-26(28,20-3-5-22(27)6-4-20)21-13-29-25(30-14-21)36-9-7-35(8-10-36)24-23-11-18(16-37(23)33-17-31-24)19-12-32-34(2)15-19/h3-6,11-17H,7-10,28H2,1-2H3/t26-/m0/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469297
PNG
(US10807985, Compound 72)
Show SMILES Cc1nn(C)cc1-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(O)c1ccc(F)cc1
Show InChI InChI=1S/C27H28FN9O/c1-18-23(16-34(3)33-18)19-12-24-25(31-17-32-37(24)15-19)35-8-10-36(11-9-35)26-29-13-21(14-30-26)27(2,38)20-4-6-22(28)7-5-20/h4-7,12-17,38H,8-11H2,1-3H3/t27-/m0/s1
PDB

GoogleScholar
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PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469302
PNG
(US10807985, Compound 77)
Show SMILES C[C@@H]1CN(CCN1c1ncc(cn1)[C@@](C)(O)c1ccc(F)cc1)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C27H28FN9O/c1-18-14-35(25-24-10-19(16-37(24)33-17-31-25)20-11-32-34(3)15-20)8-9-36(18)26-29-12-22(13-30-26)27(2,38)21-4-6-23(28)7-5-21/h4-7,10-13,15-18,38H,8-9,14H2,1-3H3/t18-,27+/m1/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469313
PNG
(US10807985, Compound 88)
Show SMILES Cc1ncc(s1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(O)c1ccc(F)cc1
Show InChI InChI=1S/C26H25FN8OS/c1-17-28-14-23(37-17)18-11-22-24(31-16-32-35(22)15-18)33-7-9-34(10-8-33)25-29-12-20(13-30-25)26(2,36)19-3-5-21(27)6-4-19/h3-6,11-16,36H,7-10H2,1-2H3/t26-/m0/s1
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469316
PNG
(US10807985, Compound 91)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(O)c1c(F)cccc1F
Show InChI InChI=1S/C26H25F2N9O/c1-26(38,23-20(27)4-3-5-21(23)28)19-12-29-25(30-13-19)36-8-6-35(7-9-36)24-22-10-17(15-37(22)33-16-31-24)18-11-32-34(2)14-18/h3-5,10-16,38H,6-9H2,1-2H3/t26-/m0/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469319
PNG
(US10807985, Compound 94)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(O)c1ccc(F)cc1F
Show InChI InChI=1S/C26H25F2N9O/c1-26(38,21-4-3-20(27)10-22(21)28)19-12-29-25(30-13-19)36-7-5-35(6-8-36)24-23-9-17(15-37(23)33-16-31-24)18-11-32-34(2)14-18/h3-4,9-16,38H,5-8H2,1-2H3/t26-/m1/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469239
PNG
(US10807985, Compound 14)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(Cc2ccc(F)cc2)cn1
Show InChI InChI=1S/C25H24FN9/c1-32-15-21(14-30-32)20-11-23-24(29-17-31-35(23)16-20)33-6-8-34(9-7-33)25-27-12-19(13-28-25)10-18-2-4-22(26)5-3-18/h2-5,11-17H,6-10H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469255
PNG
(US10807985, Compound 30)
Show SMILES C[C@](O)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cn[nH]c1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469271
PNG
(US10807985, Compound 46)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(O)c1ccc(F)cc1
Show InChI InChI=1S/C26H26FN9O/c1-26(37,20-3-5-22(27)6-4-20)21-13-28-25(29-14-21)35-9-7-34(8-10-35)24-23-11-18(16-36(23)32-17-30-24)19-12-31-33(2)15-19/h3-6,11-17,37H,7-10H2,1-2H3/t26-/m0/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469271
PNG
(US10807985, Compound 46)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(O)c1ccc(F)cc1
Show InChI InChI=1S/C26H26FN9O/c1-26(37,20-3-5-22(27)6-4-20)21-13-28-25(29-14-21)35-9-7-34(8-10-35)24-23-11-18(16-36(23)32-17-30-24)19-12-31-33(2)15-19/h3-6,11-17,37H,7-10H2,1-2H3/t26-/m0/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469320
PNG
(US10807985, Compound 95)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](O)(CF)c1ccc(F)cc1
Show InChI InChI=1S/C26H25F2N9O/c1-34-14-19(11-32-34)18-10-23-24(31-17-33-37(23)15-18)35-6-8-36(9-7-35)25-29-12-21(13-30-25)26(38,16-27)20-2-4-22(28)5-3-20/h2-5,10-15,17,38H,6-9,16H2,1H3/t26-/m1/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469340
PNG
(US10807985, Compound 115)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(O)c1c(F)cc(F)cc1F
Show InChI InChI=1S/C26H24F3N9O/c1-26(39,23-20(28)8-19(27)9-21(23)29)18-11-30-25(31-12-18)37-5-3-36(4-6-37)24-22-7-16(14-38(22)34-15-32-24)17-10-33-35(2)13-17/h7-15,39H,3-6H2,1-2H3/t26-/m0/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469235
PNG
(US10807985, Compound 10)
Show SMILES C[C@@H](c1ccccc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C26H27N9/c1-19(20-6-4-3-5-7-20)22-13-27-26(28-14-22)34-10-8-33(9-11-34)25-24-12-21(17-35(24)31-18-29-25)23-15-30-32(2)16-23/h3-7,12-19H,8-11H2,1-2H3/t19-/m0/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469237
PNG
(US10807985, Compound 12)
Show SMILES C[C@](N)(c1ccccc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cn[nH]c1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469251
PNG
(US10807985, Compound 26)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cn[nH]c1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469283
PNG
(US10807985, Compound 58)
Show SMILES C[C@@](O)(c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cn[nH]c1)c1ccc(F)cc1F
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469303
PNG
(US10807985, Compound 78)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(CO)c1ccc(F)cc1
Show InChI InChI=1S/C27H28FN9O/c1-27(17-38,21-3-5-23(28)6-4-21)22-13-29-26(30-14-22)36-9-7-35(8-10-36)25-24-11-19(16-37(24)33-18-31-25)20-12-32-34(2)15-20/h3-6,11-16,18,38H,7-10,17H2,1-2H3/t27-/m0/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469319
PNG
(US10807985, Compound 94)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(O)c1ccc(F)cc1F
Show InChI InChI=1S/C26H25F2N9O/c1-26(38,21-4-3-20(27)10-22(21)28)19-12-29-25(30-13-19)36-7-5-35(6-8-36)24-23-9-17(15-37(23)33-16-31-24)18-11-32-34(2)14-18/h3-4,9-16,38H,5-8H2,1-2H3/t26-/m1/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469325
PNG
(US10807985, Compound 100)
Show SMILES O[C@@](C(F)F)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cn[nH]c1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469336
PNG
(US10807985, Compound 111)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](N)(C(F)F)c1ccc(F)cc1
Show InChI InChI=1S/C26H25F3N10/c1-36-14-18(11-34-36)17-10-22-23(33-16-35-39(22)15-17)37-6-8-38(9-7-37)25-31-12-20(13-32-25)26(30,24(28)29)19-2-4-21(27)5-3-19/h2-5,10-16,24H,6-9,30H2,1H3/t26-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469338
PNG
(US10807985, Compound 113)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(N)c1c(F)cc(F)cc1F
Show InChI InChI=1S/C26H25F3N10/c1-26(30,23-20(28)8-19(27)9-21(23)29)18-11-31-25(32-12-18)38-5-3-37(4-6-38)24-22-7-16(14-39(22)35-15-33-24)17-10-34-36(2)13-17/h7-15H,3-6,30H2,1-2H3/t26-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469232
PNG
(US10807985, Compound 7)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(Cc2ccccc2)cn1
Show InChI InChI=1S/C25H25N9/c1-31-16-22(15-29-31)21-12-23-24(28-18-30-34(23)17-21)32-7-9-33(10-8-32)25-26-13-20(14-27-25)11-19-5-3-2-4-6-19/h2-6,12-18H,7-11H2,1H3
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n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469255
PNG
(US10807985, Compound 30)
Show SMILES C[C@](O)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cn[nH]c1
PDB

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n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469260
PNG
(US10807985, Compound 35)
Show SMILES CCn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccccc1
Show InChI InChI=1S/C27H30N10/c1-3-36-17-21(14-32-36)20-13-24-25(31-19-33-37(24)18-20)34-9-11-35(12-10-34)26-29-15-23(16-30-26)27(2,28)22-7-5-4-6-8-22/h4-8,13-19H,3,9-12,28H2,1-2H3/t27-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469260
PNG
(US10807985, Compound 35)
Show SMILES CCn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccccc1
Show InChI InChI=1S/C27H30N10/c1-3-36-17-21(14-32-36)20-13-24-25(31-19-33-37(24)18-20)34-9-11-35(12-10-34)26-29-15-23(16-30-26)27(2,28)22-7-5-4-6-8-22/h4-8,13-19H,3,9-12,28H2,1-2H3/t27-/m0/s1
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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469264
PNG
(US10807985, Compound 39)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)C(C)(C)c1ccc(F)cc1
Show InChI InChI=1S/C27H28FN9/c1-27(2,21-4-6-23(28)7-5-21)22-14-29-26(30-15-22)36-10-8-35(9-11-36)25-24-12-19(17-37(24)33-18-31-25)20-13-32-34(3)16-20/h4-7,12-18H,8-11H2,1-3H3
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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469272
PNG
(US10807985, Compound 47)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(O)c1ccccc1F
Show InChI InChI=1S/C26H26FN9O/c1-26(37,21-5-3-4-6-22(21)27)20-13-28-25(29-14-20)35-9-7-34(8-10-35)24-23-11-18(16-36(23)32-17-30-24)19-12-31-33(2)15-19/h3-6,11-17,37H,7-10H2,1-2H3/t26-/m1/s1
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n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469300
PNG
(US10807985, Compound 75)
Show SMILES CCn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(O)c1ccc(F)cc1
Show InChI InChI=1S/C27H28FN9O/c1-3-36-16-20(13-32-36)19-12-24-25(31-18-33-37(24)17-19)34-8-10-35(11-9-34)26-29-14-22(15-30-26)27(2,38)21-4-6-23(28)7-5-21/h4-7,12-18,38H,3,8-11H2,1-2H3/t27-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469311
PNG
(US10807985, Compound 86)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(N)c1ccc(F)cc1F
Show InChI InChI=1S/C26H26F2N10/c1-26(29,21-4-3-20(27)10-22(21)28)19-12-30-25(31-13-19)37-7-5-36(6-8-37)24-23-9-17(15-38(23)34-16-32-24)18-11-33-35(2)14-18/h3-4,9-16H,5-8,29H2,1-2H3/t26-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469323
PNG
(US10807985, Compound 98)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(Cc2ccccc2)cn1
Show InChI InChI=1S/C30H30N8O/c1-35(2)29(39)25-10-8-24(9-11-25)26-17-27-28(33-21-34-38(27)20-26)36-12-14-37(15-13-36)30-31-18-23(19-32-30)16-22-6-4-3-5-7-22/h3-11,17-21H,12-16H2,1-2H3
PDB

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n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469341
PNG
(US10807985, Compound 116)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(O)c1c(F)cc(F)cc1F
Show InChI InChI=1S/C26H24F3N9O/c1-26(39,23-20(28)8-19(27)9-21(23)29)18-11-30-25(31-12-18)37-5-3-36(4-6-37)24-22-7-16(14-38(22)34-15-32-24)17-10-33-35(2)13-17/h7-15,39H,3-6H2,1-2H3/t26-/m1/s1
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n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469346
PNG
(US10807985, Compound 121)
Show SMILES C[C@](O)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)C1=NC=N[N]2=CC(C=C12)c1cnn(c1)C1COC1
Show InChI InChI=1S/C28H29FN9O2/c1-28(39,21-2-4-23(29)5-3-21)22-12-30-27(31-13-22)36-8-6-35(7-9-36)26-25-10-19(14-38(25)34-18-32-26)20-11-33-37(15-20)24-16-40-17-24/h2-5,10-15,18-19,24,39H,6-9,16-17H2,1H3/t19?,28-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469288
PNG
(US10807985, Compound 63 | US10829493, Example 63 o...)
Show SMILES CCn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1
Show InChI InChI=1S/C27H29FN10/c1-3-37-16-20(13-33-37)19-12-24-25(32-18-34-38(24)17-19)35-8-10-36(11-9-35)26-30-14-22(15-31-26)27(2,29)21-4-6-23(28)7-5-21/h4-7,12-18H,3,8-11,29H2,1-2H3/t27-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469308
PNG
(US10807985, Compound 83)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(O)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H26ClN9O/c1-26(37,20-3-5-22(27)6-4-20)21-13-28-25(29-14-21)35-9-7-34(8-10-35)24-23-11-18(16-36(23)32-17-30-24)19-12-31-33(2)15-19/h3-6,11-17,37H,7-10H2,1-2H3/t26-/m0/s1
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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469321
PNG
(US10807985, Compound 96)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](O)(CF)c1ccc(F)cc1
Show InChI InChI=1S/C26H25F2N9O/c1-34-14-19(11-32-34)18-10-23-24(31-17-33-37(23)15-18)35-6-8-36(9-7-35)25-29-12-21(13-30-25)26(38,16-27)20-2-4-22(28)5-3-20/h2-5,10-15,17,38H,6-9,16H2,1H3/t26-/m0/s1
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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469341
PNG
(US10807985, Compound 116)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(O)c1c(F)cc(F)cc1F
Show InChI InChI=1S/C26H24F3N9O/c1-26(39,23-20(28)8-19(27)9-21(23)29)18-11-30-25(31-12-18)37-5-3-36(4-6-37)24-22-7-16(14-38(22)34-15-32-24)17-10-33-35(2)13-17/h7-15,39H,3-6H2,1-2H3/t26-/m1/s1
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n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469345
PNG
(US10807985, Compound 120)
Show SMILES C([C@@H]1CNCCO1)n1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(Cc2ccccc2)cn1
Show InChI InChI=1S/C29H32N10O/c1-2-4-22(5-3-1)12-23-14-31-29(32-15-23)37-9-7-36(8-10-37)28-27-13-24(19-39(27)35-21-33-28)25-16-34-38(18-25)20-26-17-30-6-11-40-26/h1-5,13-16,18-19,21,26,30H,6-12,17,20H2/t26-/m0/s1
PDB

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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469235
PNG
(US10807985, Compound 10)
Show SMILES C[C@@H](c1ccccc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C26H27N9/c1-19(20-6-4-3-5-7-20)22-13-27-26(28-14-22)34-10-8-33(9-11-34)25-24-12-21(17-35(24)31-18-29-25)23-15-30-32(2)16-23/h3-7,12-19H,8-11H2,1-2H3/t19-/m0/s1
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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469250
PNG
(US10807985, Compound 25)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(O)c1ccccc1
Show InChI InChI=1S/C26H27N9O/c1-26(36,21-6-4-3-5-7-21)22-14-27-25(28-15-22)34-10-8-33(9-11-34)24-23-12-19(17-35(23)31-18-29-24)20-13-30-32(2)16-20/h3-7,12-18,36H,8-11H2,1-2H3/t26-/m0/s1
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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469270
PNG
(US10807985, Compound 45)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(O)c1ccc(F)cc1
Show InChI InChI=1S/C26H26FN9O/c1-26(37,20-3-5-22(27)6-4-20)21-13-28-25(29-14-21)35-9-7-34(8-10-35)24-23-11-18(16-36(23)32-17-30-24)19-12-31-33(2)15-19/h3-6,11-17,37H,7-10H2,1-2H3/t26-/m1/s1
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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469283
PNG
(US10807985, Compound 58)
Show SMILES C[C@@](O)(c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cn[nH]c1)c1ccc(F)cc1F
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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469303
PNG
(US10807985, Compound 78)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(CO)c1ccc(F)cc1
Show InChI InChI=1S/C27H28FN9O/c1-27(17-38,21-3-5-23(28)6-4-21)22-13-29-26(30-14-22)36-9-7-35(8-10-36)25-24-11-19(16-37(24)33-18-31-25)20-12-32-34(2)15-20/h3-6,11-16,18,38H,7-10,17H2,1-2H3/t27-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469321
PNG
(US10807985, Compound 96)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](O)(CF)c1ccc(F)cc1
Show InChI InChI=1S/C26H25F2N9O/c1-34-14-19(11-32-34)18-10-23-24(31-17-33-37(23)15-18)35-6-8-36(9-7-35)25-29-12-21(13-30-25)26(38,16-27)20-2-4-22(28)5-3-20/h2-5,10-15,17,38H,6-9,16H2,1H3/t26-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469336
PNG
(US10807985, Compound 111)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](N)(C(F)F)c1ccc(F)cc1
Show InChI InChI=1S/C26H25F3N10/c1-36-14-18(11-34-36)17-10-22-23(33-16-35-39(22)15-17)37-6-8-38(9-7-37)25-31-12-20(13-32-25)26(30,24(28)29)19-2-4-21(27)5-3-19/h2-5,10-16,24H,6-9,30H2,1H3/t26-/m0/s1
PDB

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n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469342
PNG
(US10807985, Compound 117)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](O)(C(F)F)c1ccc(F)cc1
Show InChI InChI=1S/C26H24F3N9O/c1-35-14-18(11-33-35)17-10-22-23(32-16-34-38(22)15-17)36-6-8-37(9-7-36)25-30-12-20(13-31-25)26(39,24(28)29)19-2-4-21(27)5-3-19/h2-5,10-16,24,39H,6-9H2,1H3/t26-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469246
PNG
(US10807985, Compound 21)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(N)c1ccccc1
Show InChI InChI=1S/C26H28N10/c1-26(27,21-6-4-3-5-7-21)22-14-28-25(29-15-22)35-10-8-34(9-11-35)24-23-12-19(17-36(23)32-18-30-24)20-13-31-33(2)16-20/h3-7,12-18H,8-11,27H2,1-2H3/t26-/m1/s1
PDB

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n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469247
PNG
(US10807985, Compound 22)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccccc1
Show InChI InChI=1S/C26H28N10/c1-26(27,21-6-4-3-5-7-21)22-14-28-25(29-15-22)35-10-8-34(9-11-35)24-23-12-19(17-36(23)32-18-30-24)20-13-31-33(2)16-20/h3-7,12-18H,8-11,27H2,1-2H3/t26-/m0/s1
PDB

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n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469270
PNG
(US10807985, Compound 45)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(O)c1ccc(F)cc1
Show InChI InChI=1S/C26H26FN9O/c1-26(37,20-3-5-22(27)6-4-20)21-13-28-25(29-14-21)35-9-7-34(8-10-35)24-23-11-18(16-36(23)32-17-30-24)19-12-31-33(2)15-19/h3-6,11-17,37H,7-10H2,1-2H3/t26-/m1/s1
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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469282
PNG
(US10807985, Compound 57)
Show SMILES C[C@](O)(c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cn[nH]c1)c1ccc(F)cc1F
PDB

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n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469311
PNG
(US10807985, Compound 86)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(N)c1ccc(F)cc1F
Show InChI InChI=1S/C26H26F2N10/c1-26(29,21-4-3-20(27)10-22(21)28)19-12-30-25(31-13-19)37-7-5-36(6-8-37)24-23-9-17(15-38(23)34-16-32-24)18-11-33-35(2)14-18/h3-4,9-16H,5-8,29H2,1-2H3/t26-/m0/s1
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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469318
PNG
(US10807985, Compound 93)
Show SMILES C[C@@H]1CN(CCN1c1ncc(cn1)[C@](C)(O)c1ccc(F)cc1F)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C27H27F2N9O/c1-17-13-36(25-24-8-18(15-38(24)34-16-32-25)19-10-33-35(3)14-19)6-7-37(17)26-30-11-20(12-31-26)27(2,39)22-5-4-21(28)9-23(22)29/h4-5,8-12,14-17,39H,6-7,13H2,1-3H3/t17-,27+/m1/s1
PDB

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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469346
PNG
(US10807985, Compound 121)
Show SMILES C[C@](O)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)C1=NC=N[N]2=CC(C=C12)c1cnn(c1)C1COC1
Show InChI InChI=1S/C28H29FN9O2/c1-28(39,21-2-4-23(29)5-3-21)22-12-30-27(31-13-22)36-8-6-35(7-9-36)26-25-10-19(14-38(25)34-18-32-26)20-11-33-37(15-20)24-16-40-17-24/h2-5,10-15,18-19,24,39H,6-9,16-17H2,1H3/t19?,28-/m0/s1
PDB

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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469232
PNG
(US10807985, Compound 7)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(Cc2ccccc2)cn1
Show InChI InChI=1S/C25H25N9/c1-31-16-22(15-29-31)21-12-23-24(28-18-30-34(23)17-21)32-7-9-33(10-8-32)25-26-13-20(14-27-25)11-19-5-3-2-4-6-19/h2-6,12-18H,7-11H2,1H3
PDB

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n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469247
PNG
(US10807985, Compound 22)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccccc1
Show InChI InChI=1S/C26H28N10/c1-26(27,21-6-4-3-5-7-21)22-14-28-25(29-15-22)35-10-8-34(9-11-35)24-23-12-19(17-36(23)32-18-30-24)20-13-31-33(2)16-20/h3-7,12-18H,8-11,27H2,1-2H3/t26-/m0/s1
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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469259
PNG
(US10807985, Compound 34)
Show SMILES C[C@](N)(c1ccccc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C28H27FN8/c1-28(30,22-5-3-2-4-6-22)23-16-31-27(32-17-23)36-13-11-35(12-14-36)26-25-15-21(18-37(25)34-19-33-26)20-7-9-24(29)10-8-20/h2-10,15-19H,11-14,30H2,1H3/t28-/m0/s1
PDB

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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469274
PNG
(US10807985, Compound 49)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@H](CO)c1ccc(F)cc1
Show InChI InChI=1S/C26H26FN9O/c1-33-14-21(13-31-33)19-10-24-25(30-17-32-36(24)15-19)34-6-8-35(9-7-34)26-28-11-20(12-29-26)23(16-37)18-2-4-22(27)5-3-18/h2-5,10-15,17,23,37H,6-9,16H2,1H3/t23-/m0/s1
PDB

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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469281
PNG
(US10807985, Compound 56)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(Sc2ccccc2F)c(N)n1
Show InChI InChI=1S/C24H23FN10S/c1-32-13-17(11-29-32)16-10-19-23(28-15-30-35(19)14-16)33-6-8-34(9-7-33)24-27-12-21(22(26)31-24)36-20-5-3-2-4-18(20)25/h2-5,10-15H,6-9H2,1H3,(H2,26,27,31)
PDB

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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469304
PNG
(US10807985, Compound 79)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(CO)c1ccc(F)cc1
Show InChI InChI=1S/C27H28FN9O/c1-27(17-38,21-3-5-23(28)6-4-21)22-13-29-26(30-14-22)36-9-7-35(8-10-36)25-24-11-19(16-37(24)33-18-31-25)20-12-32-34(2)15-20/h3-6,11-16,18,38H,7-10,17H2,1-2H3/t27-/m1/s1
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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469310
PNG
(US10807985, Compound 85)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1F
Show InChI InChI=1S/C26H26F2N10/c1-26(29,21-4-3-20(27)10-22(21)28)19-12-30-25(31-13-19)37-7-5-36(6-8-37)24-23-9-17(15-38(23)34-16-32-24)18-11-33-35(2)14-18/h3-4,9-16H,5-8,29H2,1-2H3/t26-/m1/s1
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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469323
PNG
(US10807985, Compound 98)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(Cc2ccccc2)cn1
Show InChI InChI=1S/C30H30N8O/c1-35(2)29(39)25-10-8-24(9-11-25)26-17-27-28(33-21-34-38(27)20-26)36-12-14-37(15-13-36)30-31-18-23(19-32-30)16-22-6-4-3-5-7-22/h3-11,17-21H,12-16H2,1-2H3
PDB

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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469325
PNG
(US10807985, Compound 100)
Show SMILES O[C@@](C(F)F)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cn[nH]c1
PDB

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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469339
PNG
(US10807985, Compound 114)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1c(F)cc(F)cc1F
Show InChI InChI=1S/C26H25F3N10/c1-26(30,23-20(28)8-19(27)9-21(23)29)18-11-31-25(32-12-18)38-5-3-37(4-6-38)24-22-7-16(14-39(22)35-15-33-24)17-10-34-36(2)13-17/h7-15H,3-6,30H2,1-2H3/t26-/m1/s1
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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469330
PNG
(US10807985, Compound 105)
Show SMILES C[C@H](O)Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(Sc2ccccc2F)cn1
Show InChI InChI=1S/C26H26FN9OS/c1-18(37)14-35-15-20(11-31-35)19-10-23-25(30-17-32-36(23)16-19)33-6-8-34(9-7-33)26-28-12-21(13-29-26)38-24-5-3-2-4-22(24)27/h2-5,10-13,15-18,37H,6-9,14H2,1H3/t18-/m0/s1
PDB

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US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469340
PNG
(US10807985, Compound 115)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(O)c1c(F)cc(F)cc1F
Show InChI InChI=1S/C26H24F3N9O/c1-26(39,23-20(28)8-19(27)9-21(23)29)18-11-30-25(31-12-18)37-5-3-36(4-6-37)24-22-7-16(14-38(22)34-15-32-24)17-10-33-35(2)13-17/h7-15,39H,3-6H2,1-2H3/t26-/m0/s1
PDB

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US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469236
PNG
(US10807985, Compound 11)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ccc(cn1)C(O)c1ccccc1
Show InChI InChI=1S/C26H26N8O/c1-31-16-22(15-29-31)21-13-23-26(28-18-30-34(23)17-21)33-11-9-32(10-12-33)24-8-7-20(14-27-24)25(35)19-5-3-2-4-6-19/h2-8,13-18,25,35H,9-12H2,1H3
PDB

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US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469290
PNG
(US10807985, Compound 65)
Show SMILES C[C@](O)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C28H25F2N7O/c1-28(38,21-4-8-24(30)9-5-21)22-15-31-27(32-16-22)36-12-10-35(11-13-36)26-25-14-20(17-37(25)34-18-33-26)19-2-6-23(29)7-3-19/h2-9,14-18,38H,10-13H2,1H3/t28-/m0/s1
PDB

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US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469291
PNG
(US10807985, Compound 66)
Show SMILES C[C@](O)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cccc(F)c1
Show InChI InChI=1S/C28H25F2N7O/c1-28(38,21-5-7-23(29)8-6-21)22-15-31-27(32-16-22)36-11-9-35(10-12-36)26-25-14-20(17-37(25)34-18-33-26)19-3-2-4-24(30)13-19/h2-8,13-18,38H,9-12H2,1H3/t28-/m0/s1
PDB

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US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469295
PNG
(US10807985, Compound 70)
Show SMILES CC[C@@](O)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C27H28FN9O/c1-3-27(38,21-4-6-23(28)7-5-21)22-14-29-26(30-15-22)36-10-8-35(9-11-36)25-24-12-19(17-37(24)33-18-31-25)20-13-32-34(2)16-20/h4-7,12-18,38H,3,8-11H2,1-2H3/t27-/m1/s1
PDB

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US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469329
PNG
(US10807985, Compound 104)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](O)(C1CC1)c1ccc(F)cc1
Show InChI InChI=1S/C28H28FN9O/c1-35-16-20(13-33-35)19-12-25-26(32-18-34-38(25)17-19)36-8-10-37(11-9-36)27-30-14-23(15-31-27)28(39,21-2-3-21)22-4-6-24(29)7-5-22/h4-7,12-18,21,39H,2-3,8-11H2,1H3/t28-/m0/s1
PDB

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US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469343
PNG
(US10807985, Compound 118)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](O)(C(F)F)c1ccc(F)cc1
Show InChI InChI=1S/C26H24F3N9O/c1-35-14-18(11-33-35)17-10-22-23(32-16-34-38(22)15-17)36-6-8-37(9-7-36)25-30-12-20(13-31-25)26(39,24(28)29)19-2-4-21(27)5-3-19/h2-5,10-16,24,39H,6-9H2,1H3/t26-/m1/s1
PDB

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US Patent
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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469275
PNG
(US10807985, Compound 50)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@H](CO)c1ccc(F)cc1
Show InChI InChI=1S/C26H26FN9O/c1-33-14-21(13-31-33)19-10-24-25(30-17-32-36(24)15-19)34-6-8-35(9-7-34)26-28-11-20(12-29-26)23(16-37)18-2-4-22(27)5-3-18/h2-5,10-15,17,23,37H,6-9,16H2,1H3/t23-/m1/s1
PDB

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US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469293
PNG
(US10807985, Compound 68)
Show SMILES CO[C@](C)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C27H28FN9O/c1-27(38-3,21-4-6-23(28)7-5-21)22-14-29-26(30-15-22)36-10-8-35(9-11-36)25-24-12-19(17-37(24)33-18-31-25)20-13-32-34(2)16-20/h4-7,12-18H,8-11H2,1-3H3/t27-/m1/s1
PDB

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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469312
PNG
(US10807985, Compound 87)
Show SMILES Cc1ncc(s1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(O)c1ccc(F)cc1
Show InChI InChI=1S/C26H25FN8OS/c1-17-28-14-23(37-17)18-11-22-24(31-16-32-35(22)15-18)33-7-9-34(10-8-33)25-29-12-20(13-30-25)26(2,36)19-3-5-21(27)6-4-19/h3-6,11-16,36H,7-10H2,1-2H3/t26-/m1/s1
PDB

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US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469347
PNG
(US10807985, Compound 122)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](N)(c1ccc(F)cc1)C(F)(F)F
Show InChI InChI=1S/C26H24F4N10/c1-37-14-18(11-35-37)17-10-22-23(34-16-36-40(22)15-17)38-6-8-39(9-7-38)24-32-12-20(13-33-24)25(31,26(28,29)30)19-2-4-21(27)5-3-19/h2-5,10-16H,6-9,31H2,1H3/t25-/m0/s1
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469245
PNG
(US10807985, Compound 20)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)C(C)(C)c1ccccc1
Show InChI InChI=1S/C27H29N9/c1-27(2,22-7-5-4-6-8-22)23-15-28-26(29-16-23)35-11-9-34(10-12-35)25-24-13-20(18-36(24)32-19-30-25)21-14-31-33(3)17-21/h4-8,13-19H,9-12H2,1-3H3
PDB

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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469246
PNG
(US10807985, Compound 21)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(N)c1ccccc1
Show InChI InChI=1S/C26H28N10/c1-26(27,21-6-4-3-5-7-21)22-14-28-25(29-15-22)35-10-8-34(9-11-35)24-23-12-19(17-36(23)32-18-30-24)20-13-31-33(2)16-20/h3-7,12-18H,8-11,27H2,1-2H3/t26-/m1/s1
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469257
PNG
(US10807985, Compound 32)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@H](O)c1ccc(F)cc1
Show InChI InChI=1S/C25H24FN9O/c1-32-14-20(13-30-32)18-10-22-24(29-16-31-35(22)15-18)33-6-8-34(9-7-33)25-27-11-19(12-28-25)23(36)17-2-4-21(26)5-3-17/h2-5,10-16,23,36H,6-9H2,1H3/t23-/m1/s1
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469263
PNG
(US10807985, Compound 38)
Show SMILES C[C@](O)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1ccccc1
Show InChI InChI=1S/C28H26FN7O/c1-28(37,22-7-9-24(29)10-8-22)23-16-30-27(31-17-23)35-13-11-34(12-14-35)26-25-15-21(18-36(25)33-19-32-26)20-5-3-2-4-6-20/h2-10,15-19,37H,11-14H2,1H3/t28-/m0/s1
PDB

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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469287
PNG
(US10807985, Compound 62)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C28H26F2N8/c1-28(31,21-4-8-24(30)9-5-21)22-15-32-27(33-16-22)37-12-10-36(11-13-37)26-25-14-20(17-38(25)35-18-34-26)19-2-6-23(29)7-3-19/h2-9,14-18H,10-13,31H2,1H3/t28-/m0/s1
PDB

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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469298
PNG
(US10807985, Compound 73)
Show SMILES C[C@@H](c1ccc(F)cc1)c1cnc(nc1)N1CCN(C[C@H]1CO)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C27H28FN9O/c1-18(19-3-5-23(28)6-4-19)21-10-29-27(30-11-21)36-8-7-35(15-24(36)16-38)26-25-9-20(14-37(25)33-17-31-26)22-12-32-34(2)13-22/h3-6,9-14,17-18,24,38H,7-8,15-16H2,1-2H3/t18-,24-/m0/s1
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469309
PNG
(US10807985, Compound 84)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(O)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H26ClN9O/c1-26(37,20-3-5-22(27)6-4-20)21-13-28-25(29-14-21)35-9-7-34(8-10-35)24-23-11-18(16-36(23)32-17-30-24)19-12-31-33(2)15-19/h3-6,11-17,37H,7-10H2,1-2H3/t26-/m1/s1
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469327
PNG
(US10807985, Compound 102)
Show SMILES COc1ccc(cc1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(O)c1ccc(F)cc1
Show InChI InChI=1S/C29H28FN7O2/c1-29(38,22-5-7-24(30)8-6-22)23-16-31-28(32-17-23)36-13-11-35(12-14-36)27-26-15-21(18-37(26)34-19-33-27)20-3-9-25(39-2)10-4-20/h3-10,15-19,38H,11-14H2,1-2H3/t29-/m0/s1
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469348
PNG
(Synthesis of (S)-2-((4-(4-(4-(5-(2-fluorophenylthi...)
Show SMILES Fc1ccccc1Sc1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(C[C@@H]2CNCCO2)c1
Show InChI InChI=1S/C28H29FN10OS/c29-24-3-1-2-4-26(24)41-23-14-31-28(32-15-23)37-8-6-36(7-9-37)27-25-11-20(17-39(25)35-19-33-27)21-12-34-38(16-21)18-22-13-30-5-10-40-22/h1-4,11-12,14-17,19,22,30H,5-10,13,18H2/t22-/m0/s1
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US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469234
PNG
(US10807985, Compound 9)
Show SMILES C[C@H](c1ccccc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C26H27N9/c1-19(20-6-4-3-5-7-20)22-13-27-26(28-14-22)34-10-8-33(9-11-34)25-24-12-21(17-35(24)31-18-29-25)23-15-30-32(2)16-23/h3-7,12-19H,8-11H2,1-2H3/t19-/m1/s1
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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469238
PNG
(US10807985, Compound 13)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@H](N)c1ccccc1
Show InChI InChI=1S/C25H26N10/c1-32-15-21(14-30-32)19-11-22-24(29-17-31-35(22)16-19)33-7-9-34(10-8-33)25-27-12-20(13-28-25)23(26)18-5-3-2-4-6-18/h2-6,11-17,23H,7-10,26H2,1H3/t23-/m1/s1
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469239
PNG
(US10807985, Compound 14)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(Cc2ccc(F)cc2)cn1
Show InChI InChI=1S/C25H24FN9/c1-32-15-21(14-30-32)20-11-23-24(29-17-31-35(23)16-20)33-6-8-34(9-7-33)25-27-12-19(13-28-25)10-18-2-4-22(26)5-3-18/h2-5,11-17H,6-10H2,1H3
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469252
PNG
(US10807985, Compound 27)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@H](N)c1ccc(F)cc1
Show InChI InChI=1S/C25H25FN10/c1-33-14-20(13-31-33)18-10-22-24(30-16-32-36(22)15-18)34-6-8-35(9-7-34)25-28-11-19(12-29-25)23(27)17-2-4-21(26)5-3-17/h2-5,10-16,23H,6-9,27H2,1H3/t23-/m0/s1
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469261
PNG
(Synthesis of (S)—N,N-dimethyl-1-(2-(4-(6-(1-m...)
Show SMILES CN(C)[C@@H](c1ccccc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C27H30N10/c1-33(2)25(20-7-5-4-6-8-20)22-14-28-27(29-15-22)36-11-9-35(10-12-36)26-24-13-21(18-37(24)32-19-30-26)23-16-31-34(3)17-23/h4-8,13-19,25H,9-12H2,1-3H3/t25-/m0/s1
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469265
PNG
(US10807985, Compound 40)
Show SMILES CC[C@H](c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C27H28FN9/c1-3-24(19-4-6-23(28)7-5-19)21-13-29-27(30-14-21)36-10-8-35(9-11-36)26-25-12-20(17-37(25)33-18-31-26)22-15-32-34(2)16-22/h4-7,12-18,24H,3,8-11H2,1-2H3/t24-/m1/s1
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469293
PNG
(US10807985, Compound 68)
Show SMILES CO[C@](C)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C27H28FN9O/c1-27(38-3,21-4-6-23(28)7-5-21)22-14-29-26(30-15-22)36-10-8-35(9-11-36)25-24-12-19(17-37(24)33-18-31-25)20-13-32-34(2)16-20/h4-7,12-18H,8-11H2,1-3H3/t27-/m1/s1
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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469301
PNG
(US10807985, Compound 76)
Show SMILES C[C@@H]1CN(CCN1c1ncc(cn1)[C@](C)(O)c1ccc(F)cc1)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C27H28FN9O/c1-18-14-35(25-24-10-19(16-37(24)33-17-31-25)20-11-32-34(3)15-20)8-9-36(18)26-29-12-22(13-30-26)27(2,38)21-4-6-23(28)7-5-21/h4-7,10-13,15-18,38H,8-9,14H2,1-3H3/t18-,27-/m1/s1
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469312
PNG
(US10807985, Compound 87)
Show SMILES Cc1ncc(s1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(O)c1ccc(F)cc1
Show InChI InChI=1S/C26H25FN8OS/c1-17-28-14-23(37-17)18-11-22-24(31-16-32-35(22)15-18)33-7-9-34(10-8-33)25-29-12-20(13-30-25)26(2,36)19-3-5-21(27)6-4-19/h3-6,11-16,36H,7-10H2,1-2H3/t26-/m1/s1
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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469347
PNG
(US10807985, Compound 122)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](N)(c1ccc(F)cc1)C(F)(F)F
Show InChI InChI=1S/C26H24F4N10/c1-37-14-18(11-35-37)17-10-22-23(34-16-36-40(22)15-17)38-6-8-39(9-7-38)24-32-12-20(13-33-24)25(31,26(28,29)30)19-2-4-21(27)5-3-19/h2-5,10-16H,6-9,31H2,1H3/t25-/m0/s1
PDB

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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469348
PNG
(Synthesis of (S)-2-((4-(4-(4-(5-(2-fluorophenylthi...)
Show SMILES Fc1ccccc1Sc1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(C[C@@H]2CNCCO2)c1
Show InChI InChI=1S/C28H29FN10OS/c29-24-3-1-2-4-26(24)41-23-14-31-28(32-15-23)37-8-6-36(7-9-37)27-25-11-20(17-39(25)35-19-33-27)21-12-34-38(16-21)18-22-13-30-5-10-40-22/h1-4,11-12,14-17,19,22,30H,5-10,13,18H2/t22-/m0/s1
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469242
PNG
(US10807985, Compound 17)
Show SMILES Fc1ccccc1Sc1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C23H20FN9S/c24-19-3-1-2-4-21(19)34-18-12-25-23(26-13-18)32-7-5-31(6-8-32)22-20-9-16(17-10-28-29-11-17)14-33(20)30-15-27-22/h1-4,9-15H,5-8H2,(H,28,29)
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469249
PNG
(US10807985, Compound 24)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(O)c1ccccc1
Show InChI InChI=1S/C26H27N9O/c1-26(36,21-6-4-3-5-7-21)22-14-27-25(28-15-22)34-10-8-33(9-11-34)24-23-12-19(17-35(23)31-18-29-24)20-13-30-32(2)16-20/h3-7,12-18,36H,8-11H2,1-2H3/t26-/m1/s1
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469256
PNG
(US10807985, Compound 31)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@H](O)c1ccc(F)cc1
Show InChI InChI=1S/C25H24FN9O/c1-32-14-20(13-30-32)18-10-22-24(29-16-31-35(22)15-18)33-6-8-34(9-7-33)25-27-11-19(12-28-25)23(36)17-2-4-21(26)5-3-17/h2-5,10-16,23,36H,6-9H2,1H3/t23-/m0/s1
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469258
PNG
(US10807985, Compound 33)
Show SMILES NC(=O)c1ccc(cc1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(Cc2ccccc2)cn1
Show InChI InChI=1S/C28H26N8O/c29-26(37)23-8-6-22(7-9-23)24-15-25-27(32-19-33-36(25)18-24)34-10-12-35(13-11-34)28-30-16-21(17-31-28)14-20-4-2-1-3-5-20/h1-9,15-19H,10-14H2,(H2,29,37)
PDB

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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469264
PNG
(US10807985, Compound 39)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)C(C)(C)c1ccc(F)cc1
Show InChI InChI=1S/C27H28FN9/c1-27(2,21-4-6-23(28)7-5-21)22-14-29-26(30-15-22)36-10-8-35(9-11-36)25-24-12-19(17-37(24)33-18-31-25)20-13-32-34(3)16-20/h4-7,12-18H,8-11H2,1-3H3
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469273
PNG
(US10807985, Compound 48)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(O)c1ccccc1F
Show InChI InChI=1S/C26H26FN9O/c1-26(37,21-5-3-4-6-22(21)27)20-13-28-25(29-14-20)35-9-7-34(8-10-35)24-23-11-18(16-36(23)32-17-30-24)19-12-31-33(2)15-19/h3-6,11-17,37H,7-10H2,1-2H3/t26-/m0/s1
PDB

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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469279
PNG
(US10807985, Compound 54)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(O)c1ccc(F)cn1
Show InChI InChI=1S/C25H25FN10O/c1-25(37,22-4-3-20(26)13-27-22)19-11-28-24(29-12-19)35-7-5-34(6-8-35)23-21-9-17(15-36(21)32-16-30-23)18-10-31-33(2)14-18/h3-4,9-16,37H,5-8H2,1-2H3/t25-/m1/s1
PDB

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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469290
PNG
(US10807985, Compound 65)
Show SMILES C[C@](O)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C28H25F2N7O/c1-28(38,21-4-8-24(30)9-5-21)22-15-31-27(32-16-22)36-12-10-35(11-13-36)26-25-14-20(17-37(25)34-18-33-26)19-2-6-23(29)7-3-19/h2-9,14-18,38H,10-13H2,1H3/t28-/m0/s1
PDB

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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469299
PNG
(US10807985, Compound 74)
Show SMILES C[C@H](c1ccc(F)cc1)c1cnc(nc1)N1CCN(C[C@H]1CO)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C27H28FN9O/c1-18(19-3-5-23(28)6-4-19)21-10-29-27(30-11-21)36-8-7-35(15-24(36)16-38)26-25-9-20(14-37(25)33-17-31-26)22-12-32-34(2)13-22/h3-6,9-14,17-18,24,38H,7-8,15-16H2,1-2H3/t18-,24+/m1/s1
PDB

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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469322
PNG
(US10807985, Compound 97)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN([C@H](CO)C1)c1ncc(Sc2ccccc2F)cn1
Show InChI InChI=1S/C25H24FN9OS/c1-32-12-18(9-30-32)17-8-22-24(29-16-31-35(22)13-17)33-6-7-34(19(14-33)15-36)25-27-10-20(11-28-25)37-23-5-3-2-4-21(23)26/h2-5,8-13,16,19,36H,6-7,14-15H2,1H3/t19-/m0/s1
PDB

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US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469327
PNG
(US10807985, Compound 102)
Show SMILES COc1ccc(cc1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(O)c1ccc(F)cc1
Show InChI InChI=1S/C29H28FN7O2/c1-29(38,22-5-7-24(30)8-6-22)23-16-31-28(32-17-23)36-13-11-35(12-14-36)27-26-15-21(18-37(26)34-19-33-27)20-3-9-25(39-2)10-4-20/h3-10,15-19,38H,11-14H2,1-2H3/t29-/m0/s1
PDB

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US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469331
PNG
(US10807985, Compound 106)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)C(C)(C)c1c(F)cc(F)cc1F
Show InChI InChI=1S/C27H26F3N9/c1-27(2,24-21(29)9-20(28)10-22(24)30)19-12-31-26(32-13-19)38-6-4-37(5-7-38)25-23-8-17(15-39(23)35-16-33-25)18-11-34-36(3)14-18/h8-16H,4-7H2,1-3H3
PDB

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US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469335
PNG
(US10807985, Compound 110)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(O)c1ccc(F)cc1Cl
Show InChI InChI=1S/C26H25ClFN9O/c1-26(38,21-4-3-20(28)10-22(21)27)19-12-29-25(30-13-19)36-7-5-35(6-8-36)24-23-9-17(15-37(23)33-16-31-24)18-11-32-34(2)14-18/h3-4,9-16,38H,5-8H2,1-2H3/t26-/m1/s1
PDB

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US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469244
PNG
(US10807985, Compound 19)
Show SMILES C[C@@H]1CN(CCN1c1ncc(Cc2ccccc2)cn1)c1ncnn2cc(cc12)-c1cnn(C)c1C
Show InChI InChI=1S/C27H29N9/c1-19-16-34(9-10-35(19)27-28-13-22(14-29-27)11-21-7-5-4-6-8-21)26-25-12-23(17-36(25)32-18-30-26)24-15-31-33(3)20(24)2/h4-8,12-15,17-19H,9-11,16H2,1-3H3/t19-/m1/s1
PDB

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US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469253
PNG
(US10807985, Compound 28)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@H](N)c1ccc(F)cc1
Show InChI InChI=1S/C25H25FN10/c1-33-14-20(13-31-33)18-10-22-24(30-16-32-36(22)15-18)34-6-8-35(9-7-34)25-28-11-19(12-29-25)23(27)17-2-4-21(26)5-3-17/h2-5,10-16,23H,6-9,27H2,1H3/t23-/m1/s1
PDB

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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469282
PNG
(US10807985, Compound 57)
Show SMILES C[C@](O)(c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cn[nH]c1)c1ccc(F)cc1F
PDB

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UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469301
PNG
(US10807985, Compound 76)
Show SMILES C[C@@H]1CN(CCN1c1ncc(cn1)[C@](C)(O)c1ccc(F)cc1)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C27H28FN9O/c1-18-14-35(25-24-10-19(16-37(24)33-17-31-25)20-11-32-34(3)15-20)8-9-36(18)26-29-12-22(13-30-26)27(2,38)21-4-6-23(28)7-5-21/h4-7,10-13,15-18,38H,8-9,14H2,1-3H3/t18-,27-/m1/s1
PDB

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US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469322
PNG
(US10807985, Compound 97)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN([C@H](CO)C1)c1ncc(Sc2ccccc2F)cn1
Show InChI InChI=1S/C25H24FN9OS/c1-32-12-18(9-30-32)17-8-22-24(29-16-31-35(22)13-17)33-6-7-34(19(14-33)15-36)25-27-10-20(11-28-25)37-23-5-3-2-4-21(23)26/h2-5,8-13,16,19,36H,6-7,14-15H2,1H3/t19-/m0/s1
PDB

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US Patent
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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469328
PNG
(US10807985, Compound 103)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](O)(C1CC1)c1ccc(F)cc1
Show InChI InChI=1S/C28H28FN9O/c1-35-16-20(13-33-35)19-12-25-26(32-18-34-38(25)17-19)36-8-10-37(11-9-36)27-30-14-23(15-31-27)28(39,21-2-3-21)22-4-6-24(29)7-5-22/h4-7,12-18,21,39H,2-3,8-11H2,1H3/t28-/m1/s1
PDB

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US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469337
PNG
(US10807985, Compound 112)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](N)(C(F)F)c1ccc(F)cc1
Show InChI InChI=1S/C26H25F3N10/c1-36-14-18(11-34-36)17-10-22-23(33-16-35-39(22)15-17)37-6-8-38(9-7-37)25-31-12-20(13-32-25)26(30,24(28)29)19-2-4-21(27)5-3-19/h2-5,10-16,24H,6-9,30H2,1H3/t26-/m1/s1
PDB

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US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469342
PNG
(US10807985, Compound 117)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](O)(C(F)F)c1ccc(F)cc1
Show InChI InChI=1S/C26H24F3N9O/c1-35-14-18(11-33-35)17-10-22-23(32-16-34-38(22)15-17)36-6-8-37(9-7-36)25-30-12-20(13-31-25)26(39,24(28)29)19-2-4-21(27)5-3-19/h2-5,10-16,24,39H,6-9H2,1H3/t26-/m0/s1
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469233
PNG
(US10807985, Compound 8)
Show SMILES C[C@@H]1CN(CCN1c1ncc(Cc2ccccc2)cn1)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C26H27N9/c1-19-15-33(25-24-11-22(17-35(24)31-18-29-25)23-14-30-32(2)16-23)8-9-34(19)26-27-12-21(13-28-26)10-20-6-4-3-5-7-20/h3-7,11-14,16-19H,8-10,15H2,1-2H3/t19-/m1/s1
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469234
PNG
(US10807985, Compound 9)
Show SMILES C[C@H](c1ccccc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C26H27N9/c1-19(20-6-4-3-5-7-20)22-13-27-26(28-14-22)34-10-8-33(9-11-34)25-24-12-21(17-35(24)31-18-29-25)23-15-30-32(2)16-23/h3-7,12-19H,8-11H2,1-2H3/t19-/m1/s1
PDB

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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469241
PNG
(US10807985, Compound 16)
Show SMILES N#Cc1ccc(cc1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(Cc2ccccc2)cn1
Show InChI InChI=1S/C28H24N8/c29-16-22-6-8-24(9-7-22)25-15-26-27(32-20-33-36(26)19-25)34-10-12-35(13-11-34)28-30-17-23(18-31-28)14-21-4-2-1-3-5-21/h1-9,15,17-20H,10-14H2
PDB

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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469254
PNG
(US10807985, Compound 29)
Show SMILES C[C@@](O)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cn[nH]c1
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469254
PNG
(US10807985, Compound 29)
Show SMILES C[C@@](O)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cn[nH]c1
PDB

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UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469266
PNG
(US10807985, Compound 41)
Show SMILES CC[C@@H](c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C27H28FN9/c1-3-24(19-4-6-23(28)7-5-19)21-13-29-27(30-14-21)36-10-8-35(9-11-36)26-25-12-20(17-37(25)33-18-31-26)22-15-32-34(2)16-22/h4-7,12-18,24H,3,8-11H2,1-2H3/t24-/m0/s1
PDB

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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469266
PNG
(US10807985, Compound 41)
Show SMILES CC[C@@H](c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C27H28FN9/c1-3-24(19-4-6-23(28)7-5-19)21-13-29-27(30-14-21)36-10-8-35(9-11-36)26-25-12-20(17-37(25)33-18-31-26)22-15-32-34(2)16-22/h4-7,12-18,24H,3,8-11H2,1-2H3/t24-/m0/s1
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469287
PNG
(US10807985, Compound 62)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C28H26F2N8/c1-28(31,21-4-8-24(30)9-5-21)22-15-32-27(33-16-22)37-12-10-36(11-13-37)26-25-14-20(17-38(25)35-18-34-26)19-2-6-23(29)7-3-19/h2-9,14-18H,10-13,31H2,1H3/t28-/m0/s1
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469309
PNG
(US10807985, Compound 84)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(O)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H26ClN9O/c1-26(37,20-3-5-22(27)6-4-20)21-13-28-25(29-14-21)35-9-7-34(8-10-35)24-23-11-18(16-36(23)32-17-30-24)19-12-31-33(2)15-19/h3-6,11-17,37H,7-10H2,1-2H3/t26-/m1/s1
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469317
PNG
(US10807985, Compound 92)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(O)c1c(F)cccc1F
Show InChI InChI=1S/C26H25F2N9O/c1-26(38,23-20(27)4-3-5-21(23)28)19-12-29-25(30-13-19)36-8-6-35(7-9-36)24-22-10-17(15-37(22)33-16-31-24)18-11-32-34(2)14-18/h3-5,10-16,38H,6-9H2,1-2H3/t26-/m1/s1
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US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469318
PNG
(US10807985, Compound 93)
Show SMILES C[C@@H]1CN(CCN1c1ncc(cn1)[C@](C)(O)c1ccc(F)cc1F)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C27H27F2N9O/c1-17-13-36(25-24-8-18(15-38(24)34-16-32-25)19-10-33-35(3)14-19)6-7-37(17)26-30-11-20(12-31-26)27(2,39)22-5-4-21(28)9-23(22)29/h4-5,8-12,14-17,39H,6-7,13H2,1-3H3/t17-,27+/m1/s1
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US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469349
PNG
(US10807985, Compound 124)
Show SMILES CC(C)(C)OC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(O)c1ccc(F)cc1
Show InChI InChI=1S/C32H37FN8O3/c1-31(2,3)44-30(42)40-11-9-22(10-12-40)23-17-27-28(36-21-37-41(27)20-23)38-13-15-39(16-14-38)29-34-18-25(19-35-29)32(4,43)24-5-7-26(33)8-6-24/h5-9,17-21,43H,10-16H2,1-4H3/t32-/m0/s1
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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469245
PNG
(US10807985, Compound 20)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)C(C)(C)c1ccccc1
Show InChI InChI=1S/C27H29N9/c1-27(2,22-7-5-4-6-8-22)23-15-28-26(29-16-23)35-11-9-34(10-12-35)25-24-13-20(18-36(24)32-19-30-25)21-14-31-33(3)17-21/h4-8,13-19H,9-12H2,1-3H3
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469263
PNG
(US10807985, Compound 38)
Show SMILES C[C@](O)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1ccccc1
Show InChI InChI=1S/C28H26FN7O/c1-28(37,22-7-9-24(29)10-8-22)23-16-30-27(31-17-23)35-13-11-34(12-14-35)26-25-15-21(18-36(25)33-19-32-26)20-5-3-2-4-6-20/h2-10,15-19,37H,11-14H2,1H3/t28-/m0/s1
PDB

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US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469268
PNG
(US10807985, Compound 43)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(N)c1ccc(F)cc1
Show InChI InChI=1S/C26H27FN10/c1-26(28,20-3-5-22(27)6-4-20)21-13-29-25(30-14-21)36-9-7-35(8-10-36)24-23-11-18(16-37(23)33-17-31-24)19-12-32-34(2)15-19/h3-6,11-17H,7-10,28H2,1-2H3/t26-/m1/s1
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469277
PNG
(US10807985, Compound 52)
Show SMILES Cc1cc(no1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(O)c1ccc(F)cc1
Show InChI InChI=1S/C26H25FN8O2/c1-17-11-22(32-37-17)18-12-23-24(30-16-31-35(23)15-18)33-7-9-34(10-8-33)25-28-13-20(14-29-25)26(2,36)19-3-5-21(27)6-4-19/h3-6,11-16,36H,7-10H2,1-2H3/t26-/m0/s1
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469285
PNG
(US10807985, Compound 60)
Show SMILES Cc1ccc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(O)c1ccc(F)cc1
Show InChI InChI=1S/C28H27FN8O/c1-19-3-4-20(14-30-19)21-13-25-26(33-18-34-37(25)17-21)35-9-11-36(12-10-35)27-31-15-23(16-32-27)28(2,38)22-5-7-24(29)8-6-22/h3-8,13-18,38H,9-12H2,1-2H3/t28-/m0/s1
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469286
PNG
(US10807985, Compound 61)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)C1(COC1)c1ccc(F)cc1
Show InChI InChI=1S/C27H26FN9O/c1-34-14-20(11-32-34)19-10-24-25(31-18-33-37(24)15-19)35-6-8-36(9-7-35)26-29-12-22(13-30-26)27(16-38-17-27)21-2-4-23(28)5-3-21/h2-5,10-15,18H,6-9,16-17H2,1H3
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469294
PNG
(US10807985, Compound 69)
Show SMILES CC[C@](O)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C27H28FN9O/c1-3-27(38,21-4-6-23(28)7-5-21)22-14-29-26(30-15-22)36-10-8-35(9-11-36)25-24-12-19(17-37(24)33-18-31-25)20-13-32-34(2)16-20/h4-7,12-18,38H,3,8-11H2,1-2H3/t27-/m0/s1
PDB

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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469296
PNG
(US10807985, Compound 71)
Show SMILES Cc1nn(C)cc1-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(O)c1ccc(F)cc1
Show InChI InChI=1S/C27H28FN9O/c1-18-23(16-34(3)33-18)19-12-24-25(31-17-32-37(24)15-19)35-8-10-36(11-9-35)26-29-13-21(14-30-26)27(2,38)20-4-6-22(28)7-5-20/h4-7,12-17,38H,8-11H2,1-3H3/t27-/m1/s1
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469302
PNG
(US10807985, Compound 77)
Show SMILES C[C@@H]1CN(CCN1c1ncc(cn1)[C@@](C)(O)c1ccc(F)cc1)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C27H28FN9O/c1-18-14-35(25-24-10-19(16-37(24)33-17-31-25)20-11-32-34(3)15-20)8-9-36(18)26-29-12-22(13-30-26)27(2,38)21-4-6-23(28)7-5-21/h4-7,10-13,15-18,38H,8-9,14H2,1-3H3/t18-,27+/m1/s1
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469304
PNG
(US10807985, Compound 79)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(CO)c1ccc(F)cc1
Show InChI InChI=1S/C27H28FN9O/c1-27(17-38,21-3-5-23(28)6-4-21)22-13-29-26(30-14-22)36-9-7-35(8-10-36)25-24-11-19(16-37(24)33-18-31-25)20-12-32-34(2)15-20/h3-6,11-16,18,38H,7-10,17H2,1-2H3/t27-/m1/s1
PDB

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n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469306
PNG
(US10807985, Compound 81)
Show SMILES Cc1ccc(s1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(O)c1ccc(F)cc1
Show InChI InChI=1S/C27H26FN7OS/c1-18-3-8-24(37-18)19-13-23-25(31-17-32-35(23)16-19)33-9-11-34(12-10-33)26-29-14-21(15-30-26)27(2,36)20-4-6-22(28)7-5-20/h3-8,13-17,36H,9-12H2,1-2H3/t27-/m1/s1
PDB

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n/an/a 55n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469243
PNG
(US10807985, Compound 18)
Show SMILES COc1ccc(cc1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(Cc2ccccc2)cn1
Show InChI InChI=1S/C28H27N7O/c1-36-25-9-7-23(8-10-25)24-16-26-27(31-20-32-35(26)19-24)33-11-13-34(14-12-33)28-29-17-22(18-30-28)15-21-5-3-2-4-6-21/h2-10,16-20H,11-15H2,1H3
PDB

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n/an/a 55n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469280
PNG
(US10807985, Compound 55)
Show SMILES C[C@@H]1CN(CCN1c1ncc(Sc2ccccc2F)cn1)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C25H24FN9S/c1-17-13-33(24-22-9-18(15-35(22)31-16-29-24)19-10-30-32(2)14-19)7-8-34(17)25-27-11-20(12-28-25)36-23-6-4-3-5-21(23)26/h3-6,9-12,14-17H,7-8,13H2,1-2H3/t17-/m1/s1
PDB

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n/an/a 55n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469334
PNG
(US10807985, Compound 109)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(O)c1ccc(F)cc1Cl
Show InChI InChI=1S/C26H25ClFN9O/c1-26(38,21-4-3-20(28)10-22(21)27)19-12-29-25(30-13-19)36-7-5-35(6-8-36)24-23-9-17(15-37(23)33-16-31-24)18-11-32-34(2)14-18/h3-4,9-16,38H,5-8H2,1-2H3/t26-/m0/s1
PDB

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n/an/a 55n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469228
PNG
(US10807985, Compound 3)
Show SMILES COc1cccc(c1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C23H23N5O/c1-29-21-9-5-6-18(14-21)19-15-22-23(24-17-25-28(22)16-19)27-12-10-26(11-13-27)20-7-3-2-4-8-20/h2-9,14-17H,10-13H2,1H3
PDB

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n/an/a 55n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469230
PNG
(US10807985, Compound 5)
Show SMILES COc1ccc(cc1OC)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C24H25N5O2/c1-30-22-9-8-18(15-23(22)31-2)19-14-21-24(25-17-26-29(21)16-19)28-12-10-27(11-13-28)20-6-4-3-5-7-20/h3-9,14-17H,10-13H2,1-2H3
PDB

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n/an/a 55n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469248
PNG
(US10807985, Compound 23)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)C(=C)c1ccc(F)cc1
Show InChI InChI=1S/C26H24FN9/c1-18(19-3-5-23(27)6-4-19)21-12-28-26(29-13-21)35-9-7-34(8-10-35)25-24-11-20(16-36(24)32-17-30-25)22-14-31-33(2)15-22/h3-6,11-17H,1,7-10H2,2H3
PDB

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n/an/a 55n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469262
PNG
(US10807985, Compound 37)
Show SMILES CN(C)[C@H](c1ccccc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C27H30N10/c1-33(2)25(20-7-5-4-6-8-20)22-14-28-27(29-15-22)36-11-9-35(10-12-36)26-24-13-21(18-37(24)32-19-30-26)23-16-31-34(3)17-23/h4-8,13-19,25H,9-12H2,1-3H3/t25-/m1/s1
PDB

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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469289
PNG
(US10807985, Compound 64)
Show SMILES C[C@@](O)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C28H25F2N7O/c1-28(38,21-4-8-24(30)9-5-21)22-15-31-27(32-16-22)36-12-10-35(11-13-36)26-25-14-20(17-37(25)34-18-33-26)19-2-6-23(29)7-3-19/h2-9,14-18,38H,10-13H2,1H3/t28-/m1/s1
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n/an/a 55n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469292
PNG
(US10807985, Compound 67)
Show SMILES CO[C@@](C)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C27H28FN9O/c1-27(38-3,21-4-6-23(28)7-5-21)22-14-29-26(30-15-22)36-10-8-35(9-11-36)25-24-12-19(17-37(24)33-18-31-25)20-13-32-34(2)16-20/h4-7,12-18H,8-11H2,1-3H3/t27-/m0/s1
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n/an/a 55n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469326
PNG
(US10807985, Compound 101)
Show SMILES COc1cccc(c1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(O)c1ccc(F)cc1
Show InChI InChI=1S/C29H28FN7O2/c1-29(38,22-6-8-24(30)9-7-22)23-16-31-28(32-17-23)36-12-10-35(11-13-36)27-26-15-21(18-37(26)34-19-33-27)20-4-3-5-25(14-20)39-2/h3-9,14-19,38H,10-13H2,1-2H3/t29-/m0/s1
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n/an/a 55n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469267
PNG
(US10807985, Compound 42)
Show SMILES Cn1cc(cn1)-c1cc2ncnc(N3CCN(CC3)c3ncc(cn3)C(C)(C)c3ccc(F)cc3)n2n1
Show InChI InChI=1S/C26H27FN10/c1-26(2,19-4-6-21(27)7-5-19)20-14-28-24(29-15-20)35-8-10-36(11-9-35)25-31-17-30-23-12-22(33-37(23)25)18-13-32-34(3)16-18/h4-7,12-17H,8-11H2,1-3H3
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n/an/a 55n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469324
PNG
(US10807985, Compound 99)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C24H22FN9O2S/c1-31-14-18(11-29-31)17-10-22-23(28-16-30-34(22)15-17)32-6-8-33(9-7-32)24-26-12-21(13-27-24)37(35,36)20-4-2-19(25)3-5-20/h2-5,10-16H,6-9H2,1H3
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n/an/a 55n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469243
PNG
(US10807985, Compound 18)
Show SMILES COc1ccc(cc1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(Cc2ccccc2)cn1
Show InChI InChI=1S/C28H27N7O/c1-36-25-9-7-23(8-10-25)24-16-26-27(31-20-32-35(26)19-24)33-11-13-34(14-12-33)28-29-17-22(18-30-28)15-21-5-3-2-4-6-21/h2-10,16-20H,11-15H2,1H3
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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469344
PNG
(US10807985, Compound 119)
Show SMILES C[C@](O)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)C1=NC=N[N]2=CC(C=C12)c1ccc(cc1)C1CC1
Show InChI InChI=1S/C31H31FN7O/c1-31(40,25-8-10-27(32)11-9-25)26-17-33-30(34-18-26)38-14-12-37(13-15-38)29-28-16-24(19-39(28)36-20-35-29)23-6-4-22(5-7-23)21-2-3-21/h4-11,16-21,24,40H,2-3,12-15H2,1H3/t24?,31-/m0/s1
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n/an/a 55n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469307
PNG
(US10807985, Compound 82)
Show SMILES Cc1ccc(s1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(O)c1ccc(F)cc1
Show InChI InChI=1S/C27H26FN7OS/c1-18-3-8-24(37-18)19-13-23-25(31-17-32-35(23)16-19)33-9-11-34(12-10-33)26-29-14-21(15-30-26)27(2,36)20-4-6-22(28)7-5-20/h3-8,13-17,36H,9-12H2,1-2H3/t27-/m0/s1
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n/an/a 55n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469276
PNG
(US10807985, Compound 51)
Show SMILES Cc1cc(no1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(O)c1ccc(F)cc1
Show InChI InChI=1S/C26H25FN8O2/c1-17-11-22(32-37-17)18-12-23-24(30-16-31-35(23)15-18)33-7-9-34(10-8-33)25-28-13-20(14-29-25)26(2,36)19-3-5-21(27)6-4-19/h3-6,11-16,36H,7-10H2,1-2H3/t26-/m1/s1
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n/an/a 55n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469278
PNG
(US10807985, Compound 53)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(O)c1ccc(F)cn1
Show InChI InChI=1S/C25H25FN10O/c1-25(37,22-4-3-20(26)13-27-22)19-11-28-24(29-12-19)35-7-5-34(6-8-35)23-21-9-17(15-36(21)32-16-30-23)18-10-31-33(2)14-18/h3-4,9-16,37H,5-8H2,1-2H3/t25-/m0/s1
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n/an/a 55n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469284
PNG
(US10807985, Compound 59)
Show SMILES Cc1ccc(cc1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(O)c1ccc(F)cc1
Show InChI InChI=1S/C29H28FN7O/c1-20-3-5-21(6-4-20)22-15-26-27(33-19-34-37(26)18-22)35-11-13-36(14-12-35)28-31-16-24(17-32-28)29(2,38)23-7-9-25(30)10-8-23/h3-10,15-19,38H,11-14H2,1-2H3/t29-/m0/s1
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n/an/a 55n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469240
PNG
(US10807985, Compound 15)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(Oc2ccc(F)cc2)cn1
Show InChI InChI=1S/C24H22FN9O/c1-31-14-18(11-29-31)17-10-22-23(28-16-30-34(22)15-17)32-6-8-33(9-7-32)24-26-12-21(13-27-24)35-20-4-2-19(25)3-5-20/h2-5,10-16H,6-9H2,1H3
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n/an/a 55n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469305
PNG
(US10807985, Compound 80)
Show SMILES Cc1cc(F)ccc1[C@](C)(O)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C27H28FN9O/c1-18-10-22(28)4-5-23(18)27(2,38)21-13-29-26(30-14-21)36-8-6-35(7-9-36)25-24-11-19(16-37(24)33-17-31-25)20-12-32-34(3)15-20/h4-5,10-17,38H,6-9H2,1-3H3/t27-/m1/s1
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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469315
PNG
(US10807985, Compound 90)
Show SMILES Cn1cc(cn1)-c1cn2ncnc(N3CCN(CC3)c3ncc(cn3)[C@@](C)(O)c3ccc(F)cc3)c2c1F
Show InChI InChI=1S/C26H25F2N9O/c1-26(38,18-3-5-20(27)6-4-18)19-12-29-25(30-13-19)36-9-7-35(8-10-36)24-23-22(28)21(15-37(23)33-16-31-24)17-11-32-34(2)14-17/h3-6,11-16,38H,7-10H2,1-2H3/t26-/m0/s1
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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469231
PNG
(US10807985, Compound 6)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C25H26N6O/c1-28(2)25(32)20-10-8-19(9-11-20)21-16-23-24(26-18-27-31(23)17-21)30-14-12-29(13-15-30)22-6-4-3-5-7-22/h3-11,16-18H,12-15H2,1-2H3
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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469314
PNG
(US10807985, Compound 89)
Show SMILES Cn1cc(cn1)-c1cn2ncnc(N3CCN(CC3)c3ncc(cn3)[C@](C)(O)c3ccc(F)cc3)c2c1F
Show InChI InChI=1S/C26H25F2N9O/c1-26(38,18-3-5-20(27)6-4-18)19-12-29-25(30-13-19)36-9-7-35(8-10-36)24-23-22(28)21(15-37(23)33-16-31-24)17-11-32-34(2)14-17/h3-6,11-16,38H,7-10H2,1-2H3/t26-/m1/s1
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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469229
PNG
(US10807985, Compound 4)
Show SMILES COc1cc(OC)cc(c1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C24H25N5O2/c1-30-21-12-18(13-22(15-21)31-2)19-14-23-24(25-17-26-29(23)16-19)28-10-8-27(9-11-28)20-6-4-3-5-7-20/h3-7,12-17H,8-11H2,1-2H3
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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469226
PNG
(US10807985, Compound 1)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C20H21N7/c1-24-13-17(12-22-24)16-11-19-20(21-15-23-27(19)14-16)26-9-7-25(8-10-26)18-5-3-2-4-6-18/h2-6,11-15H,7-10H2,1H3
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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469227
PNG
(US10807985, Compound 2)
Show SMILES COc1ccc(cc1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C23H23N5O/c1-29-21-9-7-18(8-10-21)19-15-22-23(24-17-25-28(22)16-19)27-13-11-26(12-14-27)20-5-3-2-4-6-20/h2-10,15-17H,11-14H2,1H3
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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469333
PNG
(US10807985, Compound 108)
Show SMILES Cn1cc(cn1)-c1cn2ncnc(N3CCN(CC3)c3ncc(cn3)[C@@](C)(O)c3ccc(F)cc3)c2c1Cl
Show InChI InChI=1S/C26H25ClFN9O/c1-26(38,18-3-5-20(28)6-4-18)19-12-29-25(30-13-19)36-9-7-35(8-10-36)24-23-22(27)21(15-37(23)33-16-31-24)17-11-32-34(2)14-17/h3-6,11-16,38H,7-10H2,1-2H3/t26-/m0/s1
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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469332
PNG
(Synthesis of (S)-1-(2-(4-(5-chloro-6-(1-methyl-1H-...)
Show SMILES Cn1cc(cn1)-c1cn2ncnc(N3CCN(CC3)c3ncc(cn3)[C@](C)(O)c3ccc(F)cc3)c2c1Cl
Show InChI InChI=1S/C26H25ClFN9O/c1-26(38,18-3-5-20(28)6-4-18)19-12-29-25(30-13-19)36-9-7-35(8-10-36)24-23-22(27)21(15-37(23)33-16-31-24)17-11-32-34(2)14-17/h3-6,11-16,38H,7-10H2,1-2H3/t26-/m1/s1
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Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...


US Patent US10807985 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%