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Patent code US10807989

Compile Data Set for Download or QSAR

Found 571 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nociceptin receptor


(Homo sapiens (Human))
BDBM469875
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)NCc3ccccc3C)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C31H42N4O2/c1-24-10-7-8-13-26(24)20-32-28(36)22-34-23-30(35(29(34)37)21-25-11-9-12-25)16-18-31(19-17-30,33(2)3)27-14-5-4-6-15-27/h4-8,10,13-15,25H,9,11-12,16-23H2,1-3H3,(H,32,36)/t30-,31+
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0.400n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469999
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3cncnc3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H36N6O2/c1-31(2)27(22-9-4-3-5-10-22)13-11-26(12-14-27)19-32(25(35)33(26)17-21-7-6-8-21)18-24(34)30-23-15-28-20-29-16-23/h3-5,9-10,15-16,20-21H,6-8,11-14,17-19H2,1-2H3,(H,30,34)/t26-,27+
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0.5n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469822
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3ccc(cn3)S(C)(=O)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H39N5O4S/c1-32(2)29(23-10-5-4-6-11-23)16-14-28(15-17-29)21-33(27(36)34(28)19-22-8-7-9-22)20-26(35)31-25-13-12-24(18-30-25)39(3,37)38/h4-6,10-13,18,22H,7-9,14-17,19-21H2,1-3H3,(H,30,31,35)/t28-,29+
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GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469858
PNG
(CIS-N-(4-Cyano-5-methylsulfanyl-1H-pyrazol-3-yl)-2...)
Show SMILES CSc1[nH]nc(NC(=O)CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCC3)C2=O)c1C#N
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0.800n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469884
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[2-(1,...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)N3CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H40N4O4S/c1-28(2)27(23-9-4-3-5-10-23)13-11-26(12-14-27)21-30(25(33)31(26)19-22-7-6-8-22)20-24(32)29-15-17-36(34,35)18-16-29/h3-5,9-10,22H,6-8,11-21H2,1-2H3/t26-,27+
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GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469848
PNG
(CIS-6-[[2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3cccc(n3)C(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H38N6O3/c1-33(2)29(22-10-4-3-5-11-22)16-14-28(15-17-29)20-34(27(38)35(28)18-21-8-6-9-21)19-25(36)32-24-13-7-12-23(31-24)26(30)37/h3-5,7,10-13,21H,6,8-9,14-20H2,1-2H3,(H2,30,37)(H,31,32,36)/t28-,29+
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GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469922
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)NCCS(C)(=O)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H40N4O4S/c1-28(2)26(22-10-5-4-6-11-22)14-12-25(13-15-26)20-29(19-23(31)27-16-17-35(3,33)34)24(32)30(25)18-21-8-7-9-21/h4-6,10-11,21H,7-9,12-20H2,1-3H3,(H,27,31)/t25-,26+
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GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469908
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3cccc(n3)S(C)(=O)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H39N5O4S/c1-32(2)29(23-11-5-4-6-12-23)17-15-28(16-18-29)21-33(27(36)34(28)19-22-9-7-10-22)20-25(35)30-24-13-8-14-26(31-24)39(3,37)38/h4-6,8,11-14,22H,7,9-10,15-21H2,1-3H3,(H,30,31,35)/t28-,29+
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GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469854
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3nccs3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H35N5O2S/c1-29(2)26(21-9-4-3-5-10-21)13-11-25(12-14-26)19-30(18-22(32)28-23-27-15-16-34-23)24(33)31(25)17-20-7-6-8-20/h3-5,9-10,15-16,20H,6-8,11-14,17-19H2,1-2H3,(H,27,28,32)/t25-,26+
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GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM470058
PNG
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-3-[2-(4...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)N3CCC(CC3)S(C)(=O)=O)C(=O)N2CC2CC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H42N4O4S/c1-29(2)28(23-7-5-4-6-8-23)15-13-27(14-16-28)21-31(26(34)32(27)19-22-9-10-22)20-25(33)30-17-11-24(12-18-30)37(3,35)36/h4-8,22,24H,9-21H2,1-3H3/t27-,28+
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GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM470041
PNG
(CIS-N-(Carbamoyl-methyl)-2-[1-(cyclobutyl-methyl)-...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)N(C)CC(N)=O)C(=O)N2CC2CCC2)CC1)c1cccc(F)c1
Show InChI InChI=1S/C26H38FN5O3/c1-29(2)26(20-8-5-9-21(27)14-20)12-10-25(11-13-26)18-31(17-23(34)30(3)16-22(28)33)24(35)32(25)15-19-6-4-7-19/h5,8-9,14,19H,4,6-7,10-13,15-18H2,1-3H3,(H2,28,33)/t25-,26+
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GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM470044
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-8-(3-...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)NCCO)C(=O)N2CC2CCC2)CC1)c1cccc(F)c1
Show InChI InChI=1S/C25H37FN4O3/c1-28(2)25(20-7-4-8-21(26)15-20)11-9-24(10-12-25)18-29(17-22(32)27-13-14-31)23(33)30(24)16-19-5-3-6-19/h4,7-8,15,19,31H,3,5-6,9-14,16-18H2,1-2H3,(H,27,32)/t24-,25+
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GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM470043
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)N3CCC(CC3)S(C)(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H44N4O5S/c1-30(2)29(23-8-5-4-6-9-23)16-14-27(15-17-29)21-32(26(35)33(27)22-28(36)12-7-13-28)20-25(34)31-18-10-24(11-19-31)39(3,37)38/h4-6,8-9,24,36H,7,10-22H2,1-3H3/t27-,29+
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GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469980
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[2-(1,...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)N3CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H40N4O4S/c1-28(2)27(23-9-4-3-5-10-23)13-11-26(12-14-27)21-30(25(33)31(26)19-22-7-6-8-22)20-24(32)29-15-17-36(34,35)18-16-29/h3-5,9-10,22H,6-8,11-21H2,1-2H3/t26-,27+
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GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469785
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES COc1cccc(NC(=O)CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCC3)C2=O)n1
Show InChI InChI=1S/C29H39N5O3/c1-32(2)29(23-11-5-4-6-12-23)17-15-28(16-18-29)21-33(27(36)34(28)19-22-9-7-10-22)20-25(35)30-24-13-8-14-26(31-24)37-3/h4-6,8,11-14,22H,7,9-10,15-21H2,1-3H3,(H,30,31,35)/t28-,29+
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GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469820
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES COc1cnccc1NC(=O)CN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C29H39N5O3/c1-32(2)29(23-10-5-4-6-11-23)15-13-28(14-16-29)21-33(27(36)34(28)19-22-8-7-9-22)20-26(35)31-24-12-17-30-18-25(24)37-3/h4-6,10-12,17-18,22H,7-9,13-16,19-21H2,1-3H3,(H,30,31,35)/t28-,29+
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GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM470037
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-8-(3-...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)N(C)CCO)C(=O)N2CC2CCC2)CC1)c1cccc(F)c1
Show InChI InChI=1S/C26H39FN4O3/c1-28(2)26(21-8-5-9-22(27)16-21)12-10-25(11-13-26)19-30(18-23(33)29(3)14-15-32)24(34)31(25)17-20-6-4-7-20/h5,8-9,16,20,32H,4,6-7,10-15,17-19H2,1-3H3/t25-,26+
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GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469842
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES COc1ncc(NC(=O)CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCC3)C2=O)cn1
Show InChI InChI=1S/C28H38N6O3/c1-32(2)28(22-10-5-4-6-11-22)14-12-27(13-15-28)20-33(26(36)34(27)18-21-8-7-9-21)19-24(35)31-23-16-29-25(37-3)30-17-23/h4-6,10-11,16-17,21H,7-9,12-15,18-20H2,1-3H3,(H,31,35)/t27-,28+
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GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469872
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)NCc3cccc(C)n3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H41N5O2/c1-23-9-7-14-26(32-23)19-31-27(36)21-34-22-29(35(28(34)37)20-24-10-8-11-24)15-17-30(18-16-29,33(2)3)25-12-5-4-6-13-25/h4-7,9,12-14,24H,8,10-11,15-22H2,1-3H3,(H,31,36)/t29-,30+
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GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469856
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3ccon3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H35N5O3/c1-29(2)26(21-9-4-3-5-10-21)14-12-25(13-15-26)19-30(18-23(32)27-22-11-16-34-28-22)24(33)31(25)17-20-7-6-8-20/h3-5,9-11,16,20H,6-8,12-15,17-19H2,1-2H3,(H,27,28,32)/t25-,26+
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GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469815
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3ccc(C)nc3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H39N5O2/c1-22-12-13-25(18-30-22)31-26(35)20-33-21-28(34(27(33)36)19-23-8-7-9-23)14-16-29(17-15-28,32(2)3)24-10-5-4-6-11-24/h4-6,10-13,18,23H,7-9,14-17,19-21H2,1-3H3,(H,31,35)/t28-,29+
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GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469812
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3cccnc3C)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H39N5O2/c1-22-25(13-8-18-30-22)31-26(35)20-33-21-28(34(27(33)36)19-23-9-7-10-23)14-16-29(17-15-28,32(2)3)24-11-5-4-6-12-24/h4-6,8,11-13,18,23H,7,9-10,14-17,19-21H2,1-3H3,(H,31,35)/t28-,29+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469876
PNG
(CIS-6-[[2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2...)
Show SMILES CNC(=O)c1ccc(NC(=O)CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCC3)C2=O)nc1
Show InChI InChI=1S/C30H40N6O3/c1-31-27(38)23-12-13-25(32-18-23)33-26(37)20-35-21-29(36(28(35)39)19-22-8-7-9-22)14-16-30(17-15-29,34(2)3)24-10-5-4-6-11-24/h4-6,10-13,18,22H,7-9,14-17,19-21H2,1-3H3,(H,31,38)(H,32,33,37)/t29-,30+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469972
PNG
(CIS-2-[[2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)NCC(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H37N5O3/c1-28(2)25(20-9-4-3-5-10-20)13-11-24(12-14-25)18-29(17-22(32)27-15-21(26)31)23(33)30(24)16-19-7-6-8-19/h3-5,9-10,19H,6-8,11-18H2,1-2H3,(H2,26,31)(H,27,32)/t24-,25+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469982
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[2-(4-...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)N3CCN(CC3)S(C)(=O)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H43N5O4S/c1-29(2)28(24-10-5-4-6-11-24)14-12-27(13-15-28)22-31(26(35)33(27)20-23-8-7-9-23)21-25(34)30-16-18-32(19-17-30)38(3,36)37/h4-6,10-11,23H,7-9,12-22H2,1-3H3/t27-,28+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469811
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES COc1ccc(NC(=O)CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCC3)C2=O)cn1
Show InChI InChI=1S/C29H39N5O3/c1-32(2)29(23-10-5-4-6-11-23)16-14-28(15-17-29)21-33(27(36)34(28)19-22-8-7-9-22)20-25(35)31-24-12-13-26(37-3)30-18-24/h4-6,10-13,18,22H,7-9,14-17,19-21H2,1-3H3,(H,31,35)/t28-,29+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469863
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)NCc3cnccc3C)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H41N5O2/c1-23-12-17-31-18-25(23)19-32-27(36)21-34-22-29(35(28(34)37)20-24-8-7-9-24)13-15-30(16-14-29,33(2)3)26-10-5-4-6-11-26/h4-6,10-12,17-18,24H,7-9,13-16,19-22H2,1-3H3,(H,32,36)/t29-,30+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469807
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3cnc(C)nc3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H38N6O2/c1-21-29-16-24(17-30-21)31-25(35)19-33-20-27(34(26(33)36)18-22-8-7-9-22)12-14-28(15-13-27,32(2)3)23-10-5-4-6-11-23/h4-6,10-11,16-17,22H,7-9,12-15,18-20H2,1-3H3,(H,31,35)/t27-,28+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469787
PNG
(CIS-6-[[2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2...)
Show SMILES CNC(=O)c1cccc(NC(=O)CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCC3)C2=O)n1
Show InChI InChI=1S/C30H40N6O3/c1-31-27(38)24-13-8-14-25(32-24)33-26(37)20-35-21-29(36(28(35)39)19-22-9-7-10-22)15-17-30(18-16-29,34(2)3)23-11-5-4-6-12-23/h4-6,8,11-14,22H,7,9-10,15-21H2,1-3H3,(H,31,38)(H,32,33,37)/t29-,30+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469883
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)NC3CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H42N4O4S/c1-30(2)28(23-9-4-3-5-10-23)15-13-27(14-16-28)21-31(26(34)32(27)19-22-7-6-8-22)20-25(33)29-24-11-17-37(35,36)18-12-24/h3-5,9-10,22,24H,6-8,11-21H2,1-2H3,(H,29,33)/t27-,28+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469850
PNG
(CIS-2-[[2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)NCC(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H37N5O3/c1-28(2)25(20-9-4-3-5-10-20)13-11-24(12-14-25)18-29(17-22(32)27-15-21(26)31)23(33)30(24)16-19-7-6-8-19/h3-5,9-10,19H,6-8,11-18H2,1-2H3,(H2,26,31)(H,27,32)/t24-,25+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469841
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES COc1ncncc1NC(=O)CN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C28H38N6O3/c1-32(2)28(22-10-5-4-6-11-22)14-12-27(13-15-28)19-33(26(36)34(27)17-21-8-7-9-21)18-24(35)31-23-16-29-20-30-25(23)37-3/h4-6,10-11,16,20-21H,7-9,12-15,17-19H2,1-3H3,(H,31,35)/t27-,28+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469861
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)NCc3ccccc3O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H40N4O3/c1-32(2)30(25-12-4-3-5-13-25)17-15-29(16-18-30)22-33(28(37)34(29)20-23-9-8-10-23)21-27(36)31-19-24-11-6-7-14-26(24)35/h3-7,11-14,23,35H,8-10,15-22H2,1-2H3,(H,31,36)/t29-,30+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469998
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3cccnn3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H36N6O2/c1-31(2)27(22-10-4-3-5-11-22)15-13-26(14-16-27)20-32(25(35)33(26)18-21-8-6-9-21)19-24(34)29-23-12-7-17-28-30-23/h3-5,7,10-12,17,21H,6,8-9,13-16,18-20H2,1-2H3,(H,29,30,34)/t26-,27+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM470015
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3ccccn3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H37N5O2/c1-31(2)28(23-11-4-3-5-12-23)16-14-27(15-17-28)21-32(26(35)33(27)19-22-9-8-10-22)20-25(34)30-24-13-6-7-18-29-24/h3-7,11-13,18,22H,8-10,14-17,19-21H2,1-2H3,(H,29,30,34)/t27-,28+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469855
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3cc(C)on3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H37N5O3/c1-20-16-23(29-35-20)28-24(33)18-31-19-26(32(25(31)34)17-21-8-7-9-21)12-14-27(15-13-26,30(2)3)22-10-5-4-6-11-22/h4-6,10-11,16,21H,7-9,12-15,17-19H2,1-3H3,(H,28,29,33)/t26-,27+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469870
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES COc1ncccc1CNC(=O)CN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C30H41N5O3/c1-33(2)30(25-12-5-4-6-13-25)16-14-29(15-17-30)22-34(28(37)35(29)20-23-9-7-10-23)21-26(36)32-19-24-11-8-18-31-27(24)38-3/h4-6,8,11-13,18,23H,7,9-10,14-17,19-22H2,1-3H3,(H,32,36)/t29-,30+
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US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469847
PNG
(CIS-N-(2-Cyano-pyrimidin-5-yl)-2-[1-(cyclobutyl-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3cnc(nc3)C#N)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H35N7O2/c1-33(2)28(22-9-4-3-5-10-22)13-11-27(12-14-28)20-34(26(37)35(27)18-21-7-6-8-21)19-25(36)32-23-16-30-24(15-29)31-17-23/h3-5,9-10,16-17,21H,6-8,11-14,18-20H2,1-2H3,(H,32,36)/t27-,28+
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1.5n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469996
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3ccncn3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H36N6O2/c1-31(2)27(22-9-4-3-5-10-22)14-12-26(13-15-27)19-32(25(35)33(26)17-21-7-6-8-21)18-24(34)30-23-11-16-28-20-29-23/h3-5,9-11,16,20-21H,6-8,12-15,17-19H2,1-2H3,(H,28,29,30,34)/t26-,27+
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1.5n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469871
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES COc1ccncc1CNC(=O)CN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O
Show InChI InChI=1S/C30H41N5O3/c1-33(2)30(25-10-5-4-6-11-25)15-13-29(14-16-30)22-34(28(37)35(29)20-23-8-7-9-23)21-27(36)32-19-24-18-31-17-12-26(24)38-3/h4-6,10-12,17-18,23H,7-9,13-16,19-22H2,1-3H3,(H,32,36)/t29-,30+
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1.5n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469793
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)NCC3CCC(O)C3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H44N4O3/c1-31(2)29(24-9-4-3-5-10-24)15-13-28(14-16-29)21-32(27(36)33(28)19-22-7-6-8-22)20-26(35)30-18-23-11-12-25(34)17-23/h3-5,9-10,22-23,25,34H,6-8,11-21H2,1-2H3,(H,30,35)/t23?,25?,28-,29+
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1.60n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469990
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)NCC3(O)CCCC3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H44N4O3/c1-31(2)29(24-11-4-3-5-12-24)17-15-27(16-18-29)22-32(26(35)33(27)19-23-9-8-10-23)20-25(34)30-21-28(36)13-6-7-14-28/h3-5,11-12,23,36H,6-10,13-22H2,1-2H3,(H,30,34)/t27-,29+
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1.60n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469921
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3ncccc3O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H37N5O3/c1-31(2)28(22-10-4-3-5-11-22)15-13-27(14-16-28)20-32(26(36)33(27)18-21-8-6-9-21)19-24(35)30-25-23(34)12-7-17-29-25/h3-5,7,10-12,17,21,34H,6,8-9,13-16,18-20H2,1-2H3,(H,29,30,35)/t27-,28+
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1.60n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469869
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)NCc3cccnc3C)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H41N5O2/c1-23-25(11-8-18-31-23)19-32-27(36)21-34-22-29(35(28(34)37)20-24-9-7-10-24)14-16-30(17-15-29,33(2)3)26-12-5-4-6-13-26/h4-6,8,11-13,18,24H,7,9-10,14-17,19-22H2,1-3H3,(H,32,36)/t29-,30+
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1.60n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469835
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[2-(3-...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)N3CCCC(O)C3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H42N4O3/c1-29(2)28(23-10-4-3-5-11-23)15-13-27(14-16-28)21-31(26(35)32(27)18-22-8-6-9-22)20-25(34)30-17-7-12-24(33)19-30/h3-5,10-11,22,24,33H,6-9,12-21H2,1-2H3/t24?,27-,28+
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1.60n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469882
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3ccc(O)cn3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H37N5O3/c1-31(2)28(22-9-4-3-5-10-22)15-13-27(14-16-28)20-32(26(36)33(27)18-21-7-6-8-21)19-25(35)30-24-12-11-23(34)17-29-24/h3-5,9-12,17,21,34H,6-8,13-16,18-20H2,1-2H3,(H,29,30,35)/t27-,28+
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GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469923
PNG
(US10807989, Example SC_1153)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3ccc(cn3)S(C)(=O)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H39N5O4S/c1-32(2)29(23-10-5-4-6-11-23)16-14-28(15-17-29)21-33(27(36)34(28)19-22-8-7-9-22)20-26(35)31-25-13-12-24(18-30-25)39(3,37)38/h4-6,10-13,18,22H,7-9,14-17,19-21H2,1-3H3,(H,30,31,35)/t28-,29+
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GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469817
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3ccc(C)cn3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H39N5O2/c1-22-12-13-25(30-18-22)31-26(35)20-33-21-28(34(27(33)36)19-23-8-7-9-23)14-16-29(17-15-28,32(2)3)24-10-5-4-6-11-24/h4-6,10-13,18,23H,7-9,14-17,19-21H2,1-3H3,(H,30,31,35)/t28-,29+
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1.60n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469868
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)NC[N]3=COC=C3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H38N5O3/c1-29(2)27(23-9-4-3-5-10-23)13-11-26(12-14-27)19-31(25(34)32(26)17-22-7-6-8-22)18-24(33)28-20-30-15-16-35-21-30/h3-5,9-10,15-16,21-22H,6-8,11-14,17-20H2,1-2H3,(H,28,33)/t26-,27+
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1.60n/an/an/an/an/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM469824
PNG
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3ccc(nc3)S(C)(=O)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H39N5O4S/c1-32(2)29(23-10-5-4-6-11-23)16-14-28(15-17-29)21-33(27(36)34(28)19-22-8-7-9-22)20-25(35)31-24-12-13-26(30-18-24)39(3,37)38/h4-6,10-13,18,22H,7-9,14-17,19-21H2,1-3H3,(H,31,35)/t28-,29+
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GRÜNENTHAL GMBH

US Patent


Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...


US Patent US10807989 (2020)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%