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Patent code US10807994

Compile Data Set for Download or QSAR
Found 99 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470128
PNG
(US10807994, Compound 1.4 | US10807994, Example S-4)
Show SMILES CN1Cc2cc(Nc3ncc4C(=O)N(COc4n3)c3c(Cl)cccc3Cl)ccc2C(C)(C)C1
Show InChI InChI=1S/C24H23Cl2N5O2/c1-24(2)12-30(3)11-14-9-15(7-8-17(14)24)28-23-27-10-16-21(29-23)33-13-31(22(16)32)20-18(25)5-4-6-19(20)26/h4-10H,11-13H2,1-3H3,(H,27,28,29)
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n/an/a 9n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470134
PNG
(US10807994, Compound 1.10 | US10807994, Example S-...)
Show SMILES CC1(C)CNCc2cc(Nc3ncc4C(=O)N(COc4n3)c3c(Cl)cccc3Cl)ccc12
Show InChI InChI=1S/C23H21Cl2N5O2/c1-23(2)11-26-9-13-8-14(6-7-16(13)23)28-22-27-10-15-20(29-22)32-12-30(21(15)31)19-17(24)4-3-5-18(19)25/h3-8,10,26H,9,11-12H2,1-2H3,(H,27,28,29)
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n/an/a 11n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470175
PNG
(US10807994, Compound 1.51 | US10807994, Example S-...)
Show SMILES Clc1cccc(Cl)c1N1COc2nc(Nc3ccc4c(CNCC44CC4)c3)ncc2C1=O
Show InChI InChI=1S/C23H19Cl2N5O2/c24-17-2-1-3-18(25)19(17)30-12-32-20-15(21(30)31)10-27-22(29-20)28-14-4-5-16-13(8-14)9-26-11-23(16)6-7-23/h1-5,8,10,26H,6-7,9,11-12H2,(H,27,28,29)
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n/an/a 11n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470140
PNG
(US10807994, Compound 1.16 | US10807994, Compound 1...)
Show SMILES OCc1cc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)ccc1N1CCNCC1
Show InChI InChI=1S/C23H22Cl2N6O3/c24-17-2-1-3-18(25)20(17)31-13-34-21-16(22(31)33)11-27-23(29-21)28-15-4-5-19(14(10-15)12-32)30-8-6-26-7-9-30/h1-5,10-11,26,32H,6-9,12-13H2,(H,27,28,29)
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n/an/a 14n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470164
PNG
(US10807994, Compound 1.40 | US10807994, Example S-...)
Show SMILES Clc1cc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)ccc1N1CCNCC1
Show InChI InChI=1S/C22H19Cl3N6O2/c23-15-2-1-3-16(24)19(15)31-12-33-20-14(21(31)32)11-27-22(29-20)28-13-4-5-18(17(25)10-13)30-8-6-26-7-9-30/h1-5,10-11,26H,6-9,12H2,(H,27,28,29)
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n/an/a 20n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470203
PNG
(US10807994, Compound 1.227 | US10807994, Example S...)
Show SMILES CC1(C)NCCc2cc(Nc3ncc4C(=O)N(COc4n3)c3c(Cl)cccc3Cl)ccc12
Show InChI InChI=1S/C23H21Cl2N5O2/c1-23(2)16-7-6-14(10-13(16)8-9-27-23)28-22-26-11-15-20(29-22)32-12-30(21(15)31)19-17(24)4-3-5-18(19)25/h3-7,10-11,27H,8-9,12H2,1-2H3,(H,26,28,29)
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n/an/a 21n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470168
PNG
(US10807994, Compound 1.44 | US10807994, Example S-...)
Show SMILES Clc1cccc(Cl)c1N1COc2nc(Nc3ccc4CNCCc4c3)ncc2C1=O
Show InChI InChI=1S/C21H17Cl2N5O2/c22-16-2-1-3-17(23)18(16)28-11-30-19-15(20(28)29)10-25-21(27-19)26-14-5-4-13-9-24-7-6-12(13)8-14/h1-5,8,10,24H,6-7,9,11H2,(H,25,26,27)
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n/an/a 23n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470166
PNG
(US10807994, Compound 1.42 | US10807994, Example S-...)
Show SMILES CN1CCC(CC1)c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1CO
Show InChI InChI=1S/C25H25Cl2N5O3/c1-31-9-7-15(8-10-31)18-6-5-17(11-16(18)13-33)29-25-28-12-19-23(30-25)35-14-32(24(19)34)22-20(26)3-2-4-21(22)27/h2-6,11-12,15,33H,7-10,13-14H2,1H3,(H,28,29,30)
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n/an/a 25n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470174
PNG
(US10807994, Compound 1.50 | US10807994, Example S-...)
Show SMILES COc1cc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)ccc1C1CCNCC1
Show InChI InChI=1S/C24H23Cl2N5O3/c1-33-20-11-15(5-6-16(20)14-7-9-27-10-8-14)29-24-28-12-17-22(30-24)34-13-31(23(17)32)21-18(25)3-2-4-19(21)26/h2-6,11-12,14,27H,7-10,13H2,1H3,(H,28,29,30)
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NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470146
PNG
(US10807994, Compound 1.22 | US10807994, Example S-...)
Show SMILES CCN1Cc2cc(Nc3ncc4C(=O)N(COc4n3)c3c(Cl)cccc3Cl)ccc2C(C)(C)C1
Show InChI InChI=1S/C25H25Cl2N5O2/c1-4-31-12-15-10-16(8-9-18(15)25(2,3)13-31)29-24-28-11-17-22(30-24)34-14-32(23(17)33)21-19(26)6-5-7-20(21)27/h5-11H,4,12-14H2,1-3H3,(H,28,29,30)
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n/an/a 30n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470192
PNG
(US10807994, Compound 1.174 | US10807994, Example S...)
Show SMILES C[C@@H]1CN(CCN1)c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1F
Show InChI InChI=1S/C23H21Cl2FN6O2/c1-13-11-31(8-7-27-13)19-6-5-14(9-18(19)26)29-23-28-10-15-21(30-23)34-12-32(22(15)33)20-16(24)3-2-4-17(20)25/h2-6,9-10,13,27H,7-8,11-12H2,1H3,(H,28,29,30)/t13-/m1/s1
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n/an/a 32n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470198
PNG
(US10807994, Compound 1.223 | US10807994, Example S...)
Show SMILES CN(C)C1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C25H26Cl2N6O2/c1-31(2)17-10-12-32(13-11-17)18-8-6-16(7-9-18)29-25-28-14-19-23(30-25)35-15-33(24(19)34)22-20(26)4-3-5-21(22)27/h3-9,14,17H,10-13,15H2,1-2H3,(H,28,29,30)
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n/an/a 32n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470177
PNG
(US10807994, Compound 1.53 | US10807994, Example S-...)
Show SMILES COc1cc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)ccc1N1CCNCC1
Show InChI InChI=1S/C23H22Cl2N6O3/c1-33-19-11-14(5-6-18(19)30-9-7-26-8-10-30)28-23-27-12-15-21(29-23)34-13-31(22(15)32)20-16(24)3-2-4-17(20)25/h2-6,11-12,26H,7-10,13H2,1H3,(H,27,28,29)
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n/an/a 33n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470148
PNG
(US10807994, Compound 1.24 | US10807994, Example S-...)
Show SMILES Clc1cccc(Cl)c1N1COc2nc(Nc3ccc4CCNCc4c3)ncc2C1=O
Show InChI InChI=1S/C21H17Cl2N5O2/c22-16-2-1-3-17(23)18(16)28-11-30-19-15(20(28)29)10-25-21(27-19)26-14-5-4-12-6-7-24-9-13(12)8-14/h1-5,8,10,24H,6-7,9,11H2,(H,25,26,27)
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n/an/a 35n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470152
PNG
(US10807994, Compound 1.28 | US10807994, Example S-...)
Show SMILES CC1(C)CNCc2cc(Nc3ncc4C(=O)N(COc4n3)c3c(F)cccc3Cl)ccc12
Show InChI InChI=1S/C23H21ClFN5O2/c1-23(2)11-26-9-13-8-14(6-7-16(13)23)28-22-27-10-15-20(29-22)32-12-30(21(15)31)19-17(24)4-3-5-18(19)25/h3-8,10,26H,9,11-12H2,1-2H3,(H,27,28,29)
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NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470159
PNG
(US10807994, Compound 1.35 | US10807994, Example S-...)
Show SMILES CN1CCc2ccc(Nc3ncc4C(=O)N(COc4n3)c3c(Cl)cccc3Cl)cc2C1
Show InChI InChI=1S/C22H19Cl2N5O2/c1-28-8-7-13-5-6-15(9-14(13)11-28)26-22-25-10-16-20(27-22)31-12-29(21(16)30)19-17(23)3-2-4-18(19)24/h2-6,9-10H,7-8,11-12H2,1H3,(H,25,26,27)
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NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470127
PNG
(US10807994, Compound 1.3 | US10807994, Example S-3)
Show SMILES CC1(C)CN(Cc2cc(Nc3ncc4C(=O)N(COc4n3)c3c(Cl)cccc3Cl)ccc12)C(=O)CO
Show InChI InChI=1S/C25H23Cl2N5O4/c1-25(2)12-31(20(34)11-33)10-14-8-15(6-7-17(14)25)29-24-28-9-16-22(30-24)36-13-32(23(16)35)21-18(26)4-3-5-19(21)27/h3-9,33H,10-13H2,1-2H3,(H,28,29,30)
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n/an/a 40n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470173
PNG
(US10807994, Compound 1.49 | US10807994, Example S-...)
Show SMILES C[C@@H]1CNCCN1c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C23H22Cl2N6O2/c1-14-11-26-9-10-30(14)16-7-5-15(6-8-16)28-23-27-12-17-21(29-23)33-13-31(22(17)32)20-18(24)3-2-4-19(20)25/h2-8,12,14,26H,9-11,13H2,1H3,(H,27,28,29)/t14-/m1/s1
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n/an/a 41n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470184
PNG
(US10807994, Compound 1.60 | US10807994, Example S-...)
Show SMILES Cc1cc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)ccc1C1CCNCC1
Show InChI InChI=1S/C24H23Cl2N5O2/c1-14-11-16(5-6-17(14)15-7-9-27-10-8-15)29-24-28-12-18-22(30-24)33-13-31(23(18)32)21-19(25)3-2-4-20(21)26/h2-6,11-12,15,27H,7-10,13H2,1H3,(H,28,29,30)
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n/an/a 43.5n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470213
PNG
(US10807994, Compound 1.238 | US10807994, Example S...)
Show SMILES CC1(C)CNCc2cc(Nc3ncc4C(=O)N(CSc4n3)c3c(F)cccc3Cl)ccc12
Show InChI InChI=1S/C23H21ClFN5OS/c1-23(2)11-26-9-13-8-14(6-7-16(13)23)28-22-27-10-15-20(29-22)32-12-30(21(15)31)19-17(24)4-3-5-18(19)25/h3-8,10,26H,9,11-12H2,1-2H3,(H,27,28,29)
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n/an/a 45n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470190
PNG
(US10807994, Compound 1.96 | US10807994, Example S-...)
Show SMILES OCC1CN(CCN1)c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C23H22Cl2N6O3/c24-18-2-1-3-19(25)20(18)31-13-34-21-17(22(31)33)10-27-23(29-21)28-14-4-6-16(7-5-14)30-9-8-26-15(11-30)12-32/h1-7,10,15,26,32H,8-9,11-13H2,(H,27,28,29)
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n/an/a 47n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470144
PNG
(US10807994, Compound 1.20 | US10807994, Example S-...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1CO
Show InChI InChI=1S/C24H24Cl2N6O3/c1-30-7-9-31(10-8-30)20-6-5-16(11-15(20)13-33)28-24-27-12-17-22(29-24)35-14-32(23(17)34)21-18(25)3-2-4-19(21)26/h2-6,11-12,33H,7-10,13-14H2,1H3,(H,27,28,29)
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n/an/a 48n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470140
PNG
(US10807994, Compound 1.16 | US10807994, Compound 1...)
Show SMILES OCc1cc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)ccc1N1CCNCC1
Show InChI InChI=1S/C23H22Cl2N6O3/c24-17-2-1-3-18(25)20(17)31-13-34-21-16(22(31)33)11-27-23(29-21)28-15-4-5-19(14(10-15)12-32)30-8-6-26-7-9-30/h1-5,10-11,26,32H,6-9,12-13H2,(H,27,28,29)
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n/an/a 49n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470157
PNG
(US10807994, Compound 1.33 | US10807994, Example S-...)
Show SMILES Cc1cc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)ccc1N1CCNCC1
Show InChI InChI=1S/C23H22Cl2N6O2/c1-14-11-15(5-6-19(14)30-9-7-26-8-10-30)28-23-27-12-16-21(29-23)33-13-31(22(16)32)20-17(24)3-2-4-18(20)25/h2-6,11-12,26H,7-10,13H2,1H3,(H,27,28,29)
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n/an/a 50n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470176
PNG
(US10807994, Compound 1.52 | US10807994, Example S-...)
Show SMILES CN1CCC(CC1)c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C24H23Cl2N5O2/c1-30-11-9-16(10-12-30)15-5-7-17(8-6-15)28-24-27-13-18-22(29-24)33-14-31(23(18)32)21-19(25)3-2-4-20(21)26/h2-8,13,16H,9-12,14H2,1H3,(H,27,28,29)
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n/an/a 50.5n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470151
PNG
(US10807994, Compound 1.27 | US10807994, Example S-...)
Show SMILES Fc1cccc(Cl)c1N1COc2nc(Nc3ccc(cc3)N3CCNCC3)ncc2C1=O
Show InChI InChI=1S/C22H20ClFN6O2/c23-17-2-1-3-18(24)19(17)30-13-32-20-16(21(30)31)12-26-22(28-20)27-14-4-6-15(7-5-14)29-10-8-25-9-11-29/h1-7,12,25H,8-11,13H2,(H,26,27,28)
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n/an/a 52n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470170
PNG
(US10807994, Compound 1.46 | US10807994, Example S-...)
Show SMILES NCC(=O)N1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C24H23Cl2N7O3/c25-18-2-1-3-19(26)21(18)33-14-36-22-17(23(33)35)13-28-24(30-22)29-15-4-6-16(7-5-15)31-8-10-32(11-9-31)20(34)12-27/h1-7,13H,8-12,14,27H2,(H,28,29,30)
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n/an/a 53n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470125
PNG
(US10807994, Compound 1.1 | US10807994, Compound 1....)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C23H22Cl2N6O2/c1-29-9-11-30(12-10-29)16-7-5-15(6-8-16)27-23-26-13-17-21(28-23)33-14-31(22(17)32)20-18(24)3-2-4-19(20)25/h2-8,13H,9-12,14H2,1H3,(H,26,27,28)
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n/an/a 56n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470221
PNG
(US10807994, Compound 1.246 | US10807994, Example S...)
Show SMILES CC1(C)NCCc2cc(Nc3ncc4C(=O)N(CSc4n3)c3c(Cl)cccc3Cl)ccc12
Show InChI InChI=1S/C23H21Cl2N5OS/c1-23(2)16-7-6-14(10-13(16)8-9-27-23)28-22-26-11-15-20(29-22)32-12-30(21(15)31)19-17(24)4-3-5-18(19)25/h3-7,10-11,27H,8-9,12H2,1-2H3,(H,26,28,29)
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n/an/a 61n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470222
PNG
(US10807994, Compound 1.172 | US10807994, Example S...)
Show SMILES C[C@H]1CNCCN1c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C23H22Cl2N6O2/c1-14-11-26-9-10-30(14)16-7-5-15(6-8-16)28-23-27-12-17-21(29-23)33-13-31(22(17)32)20-18(24)3-2-4-19(20)25/h2-8,12,14,26H,9-11,13H2,1H3,(H,27,28,29)/t14-/m0/s1
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n/an/a 66n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470193
PNG
(US10807994, Compound 1.175 | US10807994, Example S...)
Show SMILES Clc1cccc(Cl)c1N1COc2nc(Nc3ccc4[nH]ccc4c3)ncc2C1=O
Show InChI InChI=1S/C20H13Cl2N5O2/c21-14-2-1-3-15(22)17(14)27-10-29-18-13(19(27)28)9-24-20(26-18)25-12-4-5-16-11(8-12)6-7-23-16/h1-9,23H,10H2,(H,24,25,26)
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n/an/a 66n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470149
PNG
(US10807994, Compound 1.25 | US10807994, Example S-...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(F)cccc2Cl)cc1
Show InChI InChI=1S/C23H22ClFN6O2/c1-29-9-11-30(12-10-29)16-7-5-15(6-8-16)27-23-26-13-17-21(28-23)33-14-31(22(17)32)20-18(24)3-2-4-19(20)25/h2-8,13H,9-12,14H2,1H3,(H,26,27,28)
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n/an/a 68n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470129
PNG
(US10807994, Compound 1.5 | US10807994, Example S-5)
Show SMILES Clc1cccc(Cl)c1N1COc2nc(Nc3ccc(cc3)N3CCNCC3)ncc2C1=O
Show InChI InChI=1S/C22H20Cl2N6O2/c23-17-2-1-3-18(24)19(17)30-13-32-20-16(21(30)31)12-26-22(28-20)27-14-4-6-15(7-5-14)29-10-8-25-9-11-29/h1-7,12,25H,8-11,13H2,(H,26,27,28)
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n/an/a 69n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470171
PNG
(US10807994, Compound 1.47 | US10807994, Example S-...)
Show SMILES C[C@H]1CN([C@H](C)CN1)c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C24H24Cl2N6O2/c1-14-12-31(15(2)10-27-14)17-8-6-16(7-9-17)29-24-28-11-18-22(30-24)34-13-32(23(18)33)21-19(25)4-3-5-20(21)26/h3-9,11,14-15,27H,10,12-13H2,1-2H3,(H,28,29,30)/t14-,15+/m0/s1
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n/an/a 70n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470136
PNG
(US10807994, Compound 1.12 | US10807994, Example S-...)
Show SMILES Clc1cccc(Cl)c1N1COc2nc(Nc3ccc(cc3)C3CCNCC3)ncc2C1=O
Show InChI InChI=1S/C23H21Cl2N5O2/c24-18-2-1-3-19(25)20(18)30-13-32-21-17(22(30)31)12-27-23(29-21)28-16-6-4-14(5-7-16)15-8-10-26-11-9-15/h1-7,12,15,26H,8-11,13H2,(H,27,28,29)
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n/an/a 73.5n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470131
PNG
(US10807994, Compound 1.7 | US10807994, Example S-7)
Show SMILES OCC(=O)N1CCc2ccc(Nc3ncc4C(=O)N(COc4n3)c3c(Cl)cccc3Cl)cc2C1
Show InChI InChI=1S/C23H19Cl2N5O4/c24-17-2-1-3-18(25)20(17)30-12-34-21-16(22(30)33)9-26-23(28-21)27-15-5-4-13-6-7-29(19(32)11-31)10-14(13)8-15/h1-5,8-9,31H,6-7,10-12H2,(H,26,27,28)
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n/an/a 74n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470191
PNG
(US10807994, Compound 1.173 | US10807994, Example S...)
Show SMILES C[C@@H]1CN(CCN1)c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C23H22Cl2N6O2/c1-14-12-30(10-9-26-14)16-7-5-15(6-8-16)28-23-27-11-17-21(29-23)33-13-31(22(17)32)20-18(24)3-2-4-19(20)25/h2-8,11,14,26H,9-10,12-13H2,1H3,(H,27,28,29)/t14-/m1/s1
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n/an/a 87n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470150
PNG
(US10807994, Compound 1.26 | US10807994, Example S-...)
Show SMILES CC1CNCCN1c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C23H22Cl2N6O2/c1-14-11-26-9-10-30(14)16-7-5-15(6-8-16)28-23-27-12-17-21(29-23)33-13-31(22(17)32)20-18(24)3-2-4-19(20)25/h2-8,12,14,26H,9-11,13H2,1H3,(H,27,28,29)
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n/an/a 88n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470216
PNG
(US10807994, Compound 1.241 | US10807994, Example S...)
Show SMILES CN1Cc2cc(Nc3ncc4C(=O)N(CSc4n3)c3c(Cl)cccc3Cl)ccc2C(C)(C)C1
Show InChI InChI=1S/C24H23Cl2N5OS/c1-24(2)12-30(3)11-14-9-15(7-8-17(14)24)28-23-27-10-16-21(29-23)33-13-31(22(16)32)20-18(25)5-4-6-19(20)26/h4-10H,11-13H2,1-3H3,(H,27,28,29)
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n/an/a 95n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470181
PNG
(US10807994, Compound 1.57 | US10807994, Example S-...)
Show SMILES CNCC(=O)N1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C25H25Cl2N7O3/c1-28-14-21(35)33-11-9-32(10-12-33)17-7-5-16(6-8-17)30-25-29-13-18-23(31-25)37-15-34(24(18)36)22-19(26)3-2-4-20(22)27/h2-8,13,28H,9-12,14-15H2,1H3,(H,29,30,31)
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n/an/a 101n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470172
PNG
(US10807994, Compound 1.48 | US10807994, Example S-...)
Show SMILES CNCCOc1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C21H19Cl2N5O3/c1-24-9-10-30-14-7-5-13(6-8-14)26-21-25-11-15-19(27-21)31-12-28(20(15)29)18-16(22)3-2-4-17(18)23/h2-8,11,24H,9-10,12H2,1H3,(H,25,26,27)
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n/an/a 103n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470160
PNG
(US10807994, Compound 1.36 | US10807994, Example S-...)
Show SMILES Clc1cccc(Cl)c1N1COc2nc(Nc3ccc(nc3)N3CCNCC3)ncc2C1=O
Show InChI InChI=1S/C21H19Cl2N7O2/c22-15-2-1-3-16(23)18(15)30-12-32-19-14(20(30)31)11-26-21(28-19)27-13-4-5-17(25-10-13)29-8-6-24-7-9-29/h1-5,10-11,24H,6-9,12H2,(H,26,27,28)
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n/an/a 104n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470194
PNG
(US10807994, Compound 1.176 | US10807994, Example S...)
Show SMILES Cc1cc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc(C)c1N1CCNCC1
Show InChI InChI=1S/C24H24Cl2N6O2/c1-14-10-16(11-15(2)20(14)31-8-6-27-7-9-31)29-24-28-12-17-22(30-24)34-13-32(23(17)33)21-18(25)4-3-5-19(21)26/h3-5,10-12,27H,6-9,13H2,1-2H3,(H,28,29,30)
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n/an/a 105n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470179
PNG
(US10807994, Compound 1.55 | US10807994, Example S-...)
Show SMILES Clc1cccc(Cl)c1N1COc2nc(Nc3ccc(N4CCNCC4)c(c3)C#N)ncc2C1=O
Show InChI InChI=1S/C23H19Cl2N7O2/c24-17-2-1-3-18(25)20(17)32-13-34-21-16(22(32)33)12-28-23(30-21)29-15-4-5-19(14(10-15)11-26)31-8-6-27-7-9-31/h1-5,10,12,27H,6-9,13H2,(H,28,29,30)
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n/an/a 106n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470197
PNG
(US10807994, Compound 1.107 | US10807994, Example S...)
Show SMILES CN(C)Cc1c[nH]c2cc(Nc3ncc4C(=O)N(COc4n3)c3c(Cl)cccc3Cl)ccc12
Show InChI InChI=1S/C23H20Cl2N6O2/c1-30(2)11-13-9-26-19-8-14(6-7-15(13)19)28-23-27-10-16-21(29-23)33-12-31(22(16)32)20-17(24)4-3-5-18(20)25/h3-10,26H,11-12H2,1-2H3,(H,27,28,29)
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n/an/a 110n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470185
PNG
(US10807994, Compound 1.61 | US10807994, Example S-...)
Show SMILES Clc1cccc(Cl)c1N1COc2nc(Nc3ccc(cc3)N3CCCNCC3)ncc2C1=O
Show InChI InChI=1S/C23H22Cl2N6O2/c24-18-3-1-4-19(25)20(18)31-14-33-21-17(22(31)32)13-27-23(29-21)28-15-5-7-16(8-6-15)30-11-2-9-26-10-12-30/h1,3-8,13,26H,2,9-12,14H2,(H,27,28,29)
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n/an/a 110n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470211
PNG
(US10807994, Compound 1.235 | US10807994, Example S...)
Show SMILES Cc1cc(Nc2ncc3C(=O)N(CSc3n2)c2c(Cl)cccc2Cl)ccc1N1CCNCC1
Show InChI InChI=1S/C23H22Cl2N6OS/c1-14-11-15(5-6-19(14)30-9-7-26-8-10-30)28-23-27-12-16-21(29-23)33-13-31(22(16)32)20-17(24)3-2-4-18(20)25/h2-6,11-12,26H,7-10,13H2,1H3,(H,27,28,29)
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n/an/a 111n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470161
PNG
(US10807994, Compound 1.37 | US10807994, Example S-...)
Show SMILES OC[C@H]1CNCCN1c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C23H22Cl2N6O3/c24-18-2-1-3-19(25)20(18)31-13-34-21-17(22(31)33)11-27-23(29-21)28-14-4-6-15(7-5-14)30-9-8-26-10-16(30)12-32/h1-7,11,16,26,32H,8-10,12-13H2,(H,27,28,29)/t16-/m1/s1
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n/an/a 113n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470186
PNG
(US10807994, Compound 1.62 | US10807994, Example S-...)
Show SMILES CC1Oc2nc(Nc3ccc(N4CCNCC4)c(CO)c3)ncc2C(=O)N1c1c(Cl)cccc1Cl
Show InChI InChI=1S/C24H24Cl2N6O3/c1-14-32(21-18(25)3-2-4-19(21)26)23(34)17-12-28-24(30-22(17)35-14)29-16-5-6-20(15(11-16)13-33)31-9-7-27-8-10-31/h2-6,11-12,14,27,33H,7-10,13H2,1H3,(H,28,29,30)
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n/an/a 123n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470204
PNG
(US10807994, Compound 1.228 | US10807994, Example S...)
Show SMILES CC1CN(CCN1)c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1Cl
Show InChI InChI=1S/C23H21Cl3N6O2/c1-13-11-31(8-7-27-13)19-6-5-14(9-18(19)26)29-23-28-10-15-21(30-23)34-12-32(22(15)33)20-16(24)3-2-4-17(20)25/h2-6,9-10,13,27H,7-8,11-12H2,1H3,(H,28,29,30)
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n/an/a 127n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470207
PNG
(US10807994, Compound 1.231 | US10807994, Example S...)
Show SMILES CC1(C)CNCc2cc(Nc3ncc4C(=O)N(CSc4n3)c3c(Cl)cccc3Cl)ccc12
Show InChI InChI=1S/C23H21Cl2N5OS/c1-23(2)11-26-9-13-8-14(6-7-16(13)23)28-22-27-10-15-20(29-22)32-12-30(21(15)31)19-17(24)4-3-5-18(19)25/h3-8,10,26H,9,11-12H2,1-2H3,(H,27,28,29)
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n/an/a 142n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470137
PNG
(US10807994, Compound 1.13 | US10807994, Example S-...)
Show SMILES OCC1CNCCN1c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C23H22Cl2N6O3/c24-18-2-1-3-19(25)20(18)31-13-34-21-17(22(31)33)11-27-23(29-21)28-14-4-6-15(7-5-14)30-9-8-26-10-16(30)12-32/h1-7,11,16,26,32H,8-10,12-13H2,(H,27,28,29)
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n/an/a 144n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470141
PNG
(US10807994, Compound 1.17 | US10807994, Example S-...)
Show SMILES CC1Oc2nc(Nc3ccc(cc3)N3CCNCC3)ncc2C(=O)N1c1c(Cl)cccc1Cl
Show InChI InChI=1S/C23H22Cl2N6O2/c1-14-31(20-18(24)3-2-4-19(20)25)22(32)17-13-27-23(29-21(17)33-14)28-15-5-7-16(8-6-15)30-11-9-26-10-12-30/h2-8,13-14,26H,9-12H2,1H3,(H,27,28,29)
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n/an/a 156n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470132
PNG
(US10807994, Compound 1.8 | US10807994, Example S-8)
Show SMILES OCC(=O)N1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C24H22Cl2N6O4/c25-18-2-1-3-19(26)21(18)32-14-36-22-17(23(32)35)12-27-24(29-22)28-15-4-6-16(7-5-15)30-8-10-31(11-9-30)20(34)13-33/h1-7,12,33H,8-11,13-14H2,(H,27,28,29)
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n/an/a 162n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470209
PNG
(US10807994, Compound 1.233 | US10807994, Example S...)
Show SMILES Clc1cccc(Cl)c1N1CSc2nc(Nc3ccc4CCNCc4c3)ncc2C1=O
Show InChI InChI=1S/C21H17Cl2N5OS/c22-16-2-1-3-17(23)18(16)28-11-30-19-15(20(28)29)10-25-21(27-19)26-14-5-4-12-6-7-24-9-13(12)8-14/h1-5,8,10,24H,6-7,9,11H2,(H,25,26,27)
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n/an/a 165n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470138
PNG
(US10807994, Compound 1.14 | US10807994, Example S-...)
Show SMILES CC1(C)CNCc2cc(Nc3ncc4C(=O)N(COc4n3)c3ccc(F)cc3Cl)ccc12
Show InChI InChI=1S/C23H21ClFN5O2/c1-23(2)11-26-9-13-7-15(4-5-17(13)23)28-22-27-10-16-20(29-22)32-12-30(21(16)31)19-6-3-14(25)8-18(19)24/h3-8,10,26H,9,11-12H2,1-2H3,(H,27,28,29)
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n/an/a 173n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470162
PNG
(US10807994, Compound 1.38 | US10807994, Example S-...)
Show SMILES OC[C@@H]1CNCCN1c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C23H22Cl2N6O3/c24-18-2-1-3-19(25)20(18)31-13-34-21-17(22(31)33)11-27-23(29-21)28-14-4-6-15(7-5-14)30-9-8-26-10-16(30)12-32/h1-7,11,16,26,32H,8-10,12-13H2,(H,27,28,29)/t16-/m0/s1
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n/an/a 176n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470205
PNG
(US10807994, Compound 1.229 | US10807994, Example S...)
Show SMILES C[C@H]1CN(CCN1)c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1Cl
Show InChI InChI=1S/C23H21Cl3N6O2/c1-13-11-31(8-7-27-13)19-6-5-14(9-18(19)26)29-23-28-10-15-21(30-23)34-12-32(22(15)33)20-16(24)3-2-4-17(20)25/h2-6,9-10,13,27H,7-8,11-12H2,1H3,(H,28,29,30)/t13-/m0/s1
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n/an/a 185n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470202
PNG
(US10807994, Compound 1.226 | US10807994, Example S...)
Show SMILES Clc1cccc(Cl)c1N1COc2nc(Nc3ccc4NCCNc4c3)ncc2C1=O
Show InChI InChI=1S/C20H16Cl2N6O2/c21-13-2-1-3-14(22)17(13)28-10-30-18-12(19(28)29)9-25-20(27-18)26-11-4-5-15-16(8-11)24-7-6-23-15/h1-5,8-9,23-24H,6-7,10H2,(H,25,26,27)
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n/an/a 188n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470142
PNG
(US10807994, Compound 1.18 | US10807994, Example S-...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C24H24Cl2N6O2/c1-2-30-10-12-31(13-11-30)17-8-6-16(7-9-17)28-24-27-14-18-22(29-24)34-15-32(23(18)33)21-19(25)4-3-5-20(21)26/h3-9,14H,2,10-13,15H2,1H3,(H,27,28,29)
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n/an/a 192n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470133
PNG
(US10807994, Compound 1.9 | US10807994, Example S-9)
Show SMILES Clc1ccccc1N1COc2nc(Nc3ccc(cc3)N3CCNCC3)ncc2C1=O
Show InChI InChI=1S/C22H21ClN6O2/c23-18-3-1-2-4-19(18)29-14-31-20-17(21(29)30)13-25-22(27-20)26-15-5-7-16(8-6-15)28-11-9-24-10-12-28/h1-8,13,24H,9-12,14H2,(H,25,26,27)
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n/an/a 193n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470178
PNG
(US10807994, Compound 1.54 | US10807994, Example S-...)
Show SMILES CNCCNc1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C21H20Cl2N6O2/c1-24-9-10-25-13-5-7-14(8-6-13)27-21-26-11-15-19(28-21)31-12-29(20(15)30)18-16(22)3-2-4-17(18)23/h2-8,11,24-25H,9-10,12H2,1H3,(H,26,27,28)
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n/an/a 200n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470210
PNG
(US10807994, Compound 1.234 | US10807994, Example S...)
Show SMILES Clc1cccc(Cl)c1N1CSc2nc(Nc3ccc4CNCCc4c3)ncc2C1=O
Show InChI InChI=1S/C21H17Cl2N5OS/c22-16-2-1-3-17(23)18(16)28-11-30-19-15(20(28)29)10-25-21(27-19)26-14-5-4-13-9-24-7-6-12(13)8-14/h1-5,8,10,24H,6-7,9,11H2,(H,25,26,27)
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n/an/a 202n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470143
PNG
(US10807994, Compound 1.19 | US10807994, Example S-...)
Show SMILES CC(C)N1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C25H26Cl2N6O2/c1-16(2)31-10-12-32(13-11-31)18-8-6-17(7-9-18)29-25-28-14-19-23(30-25)35-15-33(24(19)34)22-20(26)4-3-5-21(22)27/h3-9,14,16H,10-13,15H2,1-2H3,(H,28,29,30)
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n/an/a 206n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470153
PNG
(US10807994, Compound 1.29 | US10807994, Example S-...)
Show SMILES Fc1cc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)ccc1N1CCNCC1
Show InChI InChI=1S/C22H19Cl2FN6O2/c23-15-2-1-3-16(24)19(15)31-12-33-20-14(21(31)32)11-27-22(29-20)28-13-4-5-18(17(25)10-13)30-8-6-26-7-9-30/h1-5,10-11,26H,6-9,12H2,(H,27,28,29)
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n/an/a 212n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470200
PNG
(US10807994, Compound 1.224 | US10807994, Example S...)
Show SMILES Clc1cccc(Cl)c1N1COc2nc(Nc3ccc4NCCCc4c3)ncc2C1=O
Show InChI InChI=1S/C21H17Cl2N5O2/c22-15-4-1-5-16(23)18(15)28-11-30-19-14(20(28)29)10-25-21(27-19)26-13-6-7-17-12(9-13)3-2-8-24-17/h1,4-7,9-10,24H,2-3,8,11H2,(H,25,26,27)
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n/an/a 232n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470182
PNG
(US10807994, Compound 1.58 | US10807994, Example S-...)
Show SMILES OCCN1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C24H24Cl2N6O3/c25-19-2-1-3-20(26)21(19)32-15-35-22-18(23(32)34)14-27-24(29-22)28-16-4-6-17(7-5-16)31-10-8-30(9-11-31)12-13-33/h1-7,14,33H,8-13,15H2,(H,27,28,29)
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NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470208
PNG
(US10807994, Compound 1.232 | US10807994, Example S...)
Show SMILES CN(C)C1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(CSc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C25H26Cl2N6OS/c1-31(2)17-10-12-32(13-11-17)18-8-6-16(7-9-18)29-25-28-14-19-23(30-25)35-15-33(24(19)34)22-20(26)4-3-5-21(22)27/h3-9,14,17H,10-13,15H2,1-2H3,(H,28,29,30)
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n/an/a 273n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470130
PNG
(US10807994, Compound 1.6 | US10807994, Example S-6)
Show SMILES CC(C)(O)C(=O)N1Cc2cc(Nc3ncc4C(=O)N(COc4n3)c3c(Cl)cccc3Cl)ccc2C(C)(C)C1
Show InChI InChI=1S/C27H27Cl2N5O4/c1-26(2)13-33(24(36)27(3,4)37)12-15-10-16(8-9-18(15)26)31-25-30-11-17-22(32-25)38-14-34(23(17)35)21-19(28)6-5-7-20(21)29/h5-11,37H,12-14H2,1-4H3,(H,30,31,32)
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n/an/a 279n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470201
PNG
(US10807994, Compound 1.225 | US10807994, Example S...)
Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C24H25Cl2N5O3/c1-3-30(4-2)12-13-33-17-10-8-16(9-11-17)28-24-27-14-18-22(29-24)34-15-31(23(18)32)21-19(25)6-5-7-20(21)26/h5-11,14H,3-4,12-13,15H2,1-2H3,(H,27,28,29)
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n/an/a 282n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470169
PNG
(US10807994, Compound 1.45 | US10807994, Example S-...)
Show SMILES OC1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C23H21Cl2N5O3/c24-18-2-1-3-19(25)20(18)30-13-33-21-17(22(30)32)12-26-23(28-21)27-14-4-6-15(7-5-14)29-10-8-16(31)9-11-29/h1-7,12,16,31H,8-11,13H2,(H,26,27,28)
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n/an/a 288n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470220
PNG
(US10807994, Compound 1.245 | US10807994, Example S...)
Show SMILES CN(C)C1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(CSc3n2)c2c(F)cccc2Cl)cc1Cl
Show InChI InChI=1S/C25H25Cl2FN6OS/c1-32(2)16-8-10-33(11-9-16)21-7-6-15(12-19(21)27)30-25-29-13-17-23(31-25)36-14-34(24(17)35)22-18(26)4-3-5-20(22)28/h3-7,12-13,16H,8-11,14H2,1-2H3,(H,29,30,31)
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n/an/a 297n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470215
PNG
(US10807994, Compound 1.240 | US10807994, Example S...)
Show SMILES CN(C)C1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(CSc3n2)c2c(Cl)cccc2Cl)cc1Cl
Show InChI InChI=1S/C25H25Cl3N6OS/c1-32(2)16-8-10-33(11-9-16)21-7-6-15(12-20(21)28)30-25-29-13-17-23(31-25)36-14-34(24(17)35)22-18(26)4-3-5-19(22)27/h3-7,12-13,16H,8-11,14H2,1-2H3,(H,29,30,31)
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n/an/a 303n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470154
PNG
(US10807994, Compound 1.30 | US10807994, Example S-...)
Show SMILES Cc1cccc(Cl)c1N1COc2nc(Nc3ccc(cc3)N3CCNCC3)ncc2C1=O
Show InChI InChI=1S/C23H23ClN6O2/c1-15-3-2-4-19(24)20(15)30-14-32-21-18(22(30)31)13-26-23(28-21)27-16-5-7-17(8-6-16)29-11-9-25-10-12-29/h2-8,13,25H,9-12,14H2,1H3,(H,26,27,28)
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n/an/a 325n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470217
PNG
(US10807994, Compound 1.242 | US10807994, Example S...)
Show SMILES COc1cc(Nc2ncc3C(=O)N(CSc3n2)c2c(Cl)cccc2Cl)ccc1N1CCC(CC1)N(C)C
Show InChI InChI=1S/C26H28Cl2N6O2S/c1-32(2)17-9-11-33(12-10-17)21-8-7-16(13-22(21)36-3)30-26-29-14-18-24(31-26)37-15-34(25(18)35)23-19(27)5-4-6-20(23)28/h4-8,13-14,17H,9-12,15H2,1-3H3,(H,29,30,31)
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NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470212
PNG
(US10807994, Compound 1.236 | US10807994, Example S...)
Show SMILES Clc1cc(Nc2ncc3C(=O)N(CSc3n2)c2c(Cl)cccc2Cl)ccc1N1CCNCC1
Show InChI InChI=1S/C22H19Cl3N6OS/c23-15-2-1-3-16(24)19(15)31-12-33-20-14(21(31)32)11-27-22(29-20)28-13-4-5-18(17(25)10-13)30-8-6-26-7-9-30/h1-5,10-11,26H,6-9,12H2,(H,27,28,29)
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n/an/a 335n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470223
PNG
(US10807994, Compound 1.919 | US10807994, Example S...)
Show SMILES C[C@@H]1CN(CCN1)c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1Cl
Show InChI InChI=1S/C23H21Cl3N6O2/c1-13-11-31(8-7-27-13)19-6-5-14(9-18(19)26)29-23-28-10-15-21(30-23)34-12-32(22(15)33)20-16(24)3-2-4-17(20)25/h2-6,9-10,13,27H,7-8,11-12H2,1H3,(H,28,29,30)/t13-/m1/s1
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NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470219
PNG
(US10807994, Compound 1.244 | US10807994, Example S...)
Show SMILES CC1CN(CCN1)c1ccc(Nc2ncc3C(=O)N(CSc3n2)c2c(Cl)cccc2Cl)cc1Cl
Show InChI InChI=1S/C23H21Cl3N6OS/c1-13-11-31(8-7-27-13)19-6-5-14(9-18(19)26)29-23-28-10-15-21(30-23)34-12-32(22(15)33)20-16(24)3-2-4-17(20)25/h2-6,9-10,13,27H,7-8,11-12H2,1H3,(H,28,29,30)
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n/an/a 351n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470125
PNG
(US10807994, Compound 1.1 | US10807994, Compound 1....)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C23H22Cl2N6O2/c1-29-9-11-30(12-10-29)16-7-5-15(6-8-16)27-23-26-13-17-21(28-23)33-14-31(22(17)32)20-18(24)3-2-4-19(20)25/h2-8,13H,9-12,14H2,1H3,(H,26,27,28)
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n/an/a 366n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470167
PNG
(US10807994, Compound 1.43 | US10807994, Example S-...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cncc2Cl)cc1
Show InChI InChI=1S/C22H21Cl2N7O2/c1-29-6-8-30(9-7-29)15-4-2-14(3-5-15)27-22-26-10-16-20(28-22)33-13-31(21(16)32)19-17(23)11-25-12-18(19)24/h2-5,10-12H,6-9,13H2,1H3,(H,26,27,28)
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n/an/a 479n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470199
PNG
(US10807994, Compound 1.121 | US10807994, Example S...)
Show SMILES Clc1cccc(Cl)c1N1COc2nc(Nc3ccc4CCCNc4c3)ncc2C1=O
Show InChI InChI=1S/C21H17Cl2N5O2/c22-15-4-1-5-16(23)18(15)28-11-30-19-14(20(28)29)10-25-21(27-19)26-13-7-6-12-3-2-8-24-17(12)9-13/h1,4-7,9-10,24H,2-3,8,11H2,(H,25,26,27)
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n/an/a 501n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470214
PNG
(US10807994, Compound 1.239 | US10807994, Example S...)
Show SMILES CN(C)C1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(CSc3n2)c2c(Cl)cccc2Cl)cc1C#N
Show InChI InChI=1S/C26H25Cl2N7OS/c1-33(2)18-8-10-34(11-9-18)22-7-6-17(12-16(22)13-29)31-26-30-14-19-24(32-26)37-15-35(25(19)36)23-20(27)4-3-5-21(23)28/h3-7,12,14,18H,8-11,15H2,1-2H3,(H,30,31,32)
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n/an/a 508n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470163
PNG
(US10807994, Compound 1.39 | US10807994, Example S-...)
Show SMILES Fc1cccc(F)c1N1COc2nc(Nc3ccc(cc3)N3CCNCC3)ncc2C1=O
Show InChI InChI=1S/C22H20F2N6O2/c23-17-2-1-3-18(24)19(17)30-13-32-20-16(21(30)31)12-26-22(28-20)27-14-4-6-15(7-5-14)29-10-8-25-9-11-29/h1-7,12,25H,8-11,13H2,(H,26,27,28)
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n/an/a 540n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470206
PNG
(US10807994, Compound 1.230 | US10807994, Example S...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(CSc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C23H22Cl2N6OS/c1-29-9-11-30(12-10-29)16-7-5-15(6-8-16)27-23-26-13-17-21(28-23)33-14-31(22(17)32)20-18(24)3-2-4-19(20)25/h2-8,13H,9-12,14H2,1H3,(H,26,27,28)
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n/an/a 561n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470147
PNG
(US10807994, Compound 1.23 | US10807994, Example S-...)
Show SMILES Clc1cccc(Cl)c1N1COc2nc(Nc3ccc4CCNC(=O)c4c3)ncc2C1=O
Show InChI InChI=1S/C21H15Cl2N5O3/c22-15-2-1-3-16(23)17(15)28-10-31-19-14(20(28)30)9-25-21(27-19)26-12-5-4-11-6-7-24-18(29)13(11)8-12/h1-5,8-9H,6-7,10H2,(H,24,29)(H,25,26,27)
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n/an/a 607n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470195
PNG
(US10807994, Compound 1.87 | US10807994, Example S-...)
Show SMILES Clc1cccc(Cl)c1N1COc2nc(Nc3ccc4[nH]ncc4c3)ncc2C1=O
Show InChI InChI=1S/C19H12Cl2N6O2/c20-13-2-1-3-14(21)16(13)27-9-29-17-12(18(27)28)8-22-19(25-17)24-11-4-5-15-10(6-11)7-23-26-15/h1-8H,9H2,(H,23,26)(H,22,24,25)
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n/an/a 777n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470165
PNG
(US10807994, Compound 1.41 | US10807994, Example S-...)
Show SMILES Clc1cccc(Cl)c1N1COc2nc(Nc3ccc(cc3)N3CCNCC3=O)ncc2C1=O
Show InChI InChI=1S/C22H18Cl2N6O3/c23-16-2-1-3-17(24)19(16)30-12-33-20-15(21(30)32)10-26-22(28-20)27-13-4-6-14(7-5-13)29-9-8-25-11-18(29)31/h1-7,10,25H,8-9,11-12H2,(H,26,27,28)
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n/an/a 791n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470135
PNG
(US10807994, Compound 1.11 | US10807994, Example S-...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(COc3n2)c2ccc(F)cc2Cl)cc1
Show InChI InChI=1S/C23H22ClFN6O2/c1-29-8-10-30(11-9-29)17-5-3-16(4-6-17)27-23-26-13-18-21(28-23)33-14-31(22(18)32)20-7-2-15(25)12-19(20)24/h2-7,12-13H,8-11,14H2,1H3,(H,26,27,28)
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n/an/a 837n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470218
PNG
(US10807994, Compound 1.243 | US10807994, Example S...)
Show SMILES CC1CNCCN1c1ccc(Nc2ncc3C(=O)N(CSc3n2)c2c(Cl)cccc2Cl)cc1Cl
Show InChI InChI=1S/C23H21Cl3N6OS/c1-13-10-27-7-8-31(13)19-6-5-14(9-18(19)26)29-23-28-11-15-21(30-23)34-12-32(22(15)33)20-16(24)3-2-4-17(20)25/h2-6,9,11,13,27H,7-8,10,12H2,1H3,(H,28,29,30)
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n/an/a 948n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470189
PNG
(US10807994, Compound 1.65 | US10807994, Example S-...)
Show SMILES FC(F)CN1CCc2ccc(Nc3ncc4C(=O)N(COc4n3)c3c(Cl)cccc3Cl)cc2C1
Show InChI InChI=1S/C23H19Cl2F2N5O2/c24-17-2-1-3-18(25)20(17)32-12-34-21-16(22(32)33)9-28-23(30-21)29-15-5-4-13-6-7-31(11-19(26)27)10-14(13)8-15/h1-5,8-9,19H,6-7,10-12H2,(H,28,29,30)
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n/an/a 1.33E+3n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470145
PNG
(US10807994, Compound 1.21 | US10807994, Example S-...)
Show SMILES Clc1cccc(Cl)c1N1COc2nc(Nc3ccc(cc3)N3CCN(CC3)C3CC3)ncc2C1=O
Show InChI InChI=1S/C25H24Cl2N6O2/c26-20-2-1-3-21(27)22(20)33-15-35-23-19(24(33)34)14-28-25(30-23)29-16-4-6-17(7-5-16)31-10-12-32(13-11-31)18-8-9-18/h1-7,14,18H,8-13,15H2,(H,28,29,30)
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n/an/a 1.39E+3n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470139
PNG
(US10807994, Compound 1.15 | US10807994, Example S-...)
Show SMILES CCS(=O)(=O)N1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C24H24Cl2N6O4S/c1-2-37(34,35)31-12-10-30(11-13-31)17-8-6-16(7-9-17)28-24-27-14-18-22(29-24)36-15-32(23(18)33)21-19(25)4-3-5-20(21)26/h3-9,14H,2,10-13,15H2,1H3,(H,27,28,29)
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n/an/a 1.56E+3n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470126
PNG
(US10807994, Compound 1.2 | US10807994, Example S-2)
Show SMILES Clc1cccc(Cl)c1N1COc2nc(Nc3ccc(cc3)N3CCOCC3)ncc2C1=O
Show InChI InChI=1S/C22H19Cl2N5O3/c23-17-2-1-3-18(24)19(17)29-13-32-20-16(21(29)30)12-25-22(27-20)26-14-4-6-15(7-5-14)28-8-10-31-11-9-28/h1-7,12H,8-11,13H2,(H,25,26,27)
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n/an/a 3.26E+3n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470187
PNG
(US10807994, Compound 1.63 | US10807994, Example S-...)
Show SMILES FC1(F)CCN(CC1)c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C23H19Cl2F2N5O2/c24-17-2-1-3-18(25)19(17)32-13-34-20-16(21(32)33)12-28-22(30-20)29-14-4-6-15(7-5-14)31-10-8-23(26,27)9-11-31/h1-7,12H,8-11,13H2,(H,28,29,30)
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n/an/a>5.00E+3n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470196
PNG
(US10807994, Compound 1.104 | US10807994, Example S...)
Show SMILES CN(c1ccc(cc1)N1CCNCC1)c1ncc2C(=O)N(COc2n1)c1c(Cl)cccc1Cl
Show InChI InChI=1S/C23H22Cl2N6O2/c1-29(15-5-7-16(8-6-15)30-11-9-26-10-12-30)23-27-13-17-21(28-23)33-14-31(22(17)32)20-18(24)3-2-4-19(20)25/h2-8,13,26H,9-12,14H2,1H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470183
PNG
(US10807994, Compound 1.59 | US10807994, Example S-...)
Show SMILES CC1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C24H23Cl2N5O2/c1-15-9-11-30(12-10-15)17-7-5-16(6-8-17)28-24-27-13-18-22(29-24)33-14-31(23(18)32)21-19(25)3-2-4-20(21)26/h2-8,13,15H,9-12,14H2,1H3,(H,27,28,29)
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n/an/a>5.00E+3n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470180
PNG
(US10807994, Compound 1.56 | US10807994, Example S-...)
Show SMILES Clc1cccc(Cl)c1N1COc2nc(Nc3ccc(cc3)N3CCCC3)ncc2C1=O
Show InChI InChI=1S/C22H19Cl2N5O2/c23-17-4-3-5-18(24)19(17)29-13-31-20-16(21(29)30)12-25-22(27-20)26-14-6-8-15(9-7-14)28-10-1-2-11-28/h3-9,12H,1-2,10-11,13H2,(H,25,26,27)
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n/an/a>5.00E+3n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470188
PNG
(US10807994, Compound 1.64 | US10807994, Example S-...)
Show SMILES Clc1cccc(Cl)c1N1COc2nc(Nc3ccc4cnccc4c3)ncc2C1=O
Show InChI InChI=1S/C21H13Cl2N5O2/c22-16-2-1-3-17(23)18(16)28-11-30-19-15(20(28)29)10-25-21(27-19)26-14-5-4-13-9-24-7-6-12(13)8-14/h1-10H,11H2,(H,25,26,27)
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n/an/a>5.00E+3n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM470155
PNG
(US10807994, Compound 1.31 | US10807994, Example S-...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ccc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C24H23Cl2N5O2/c1-29-11-13-30(14-12-29)17-7-5-16(6-8-17)27-21-10-9-18-23(28-21)33-15-31(24(18)32)22-19(25)3-2-4-20(22)26/h2-10H,11-15H2,1H3,(H,27,28)
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n/an/a 3.00E+4n/an/an/an/an/an/a



NUVATION BIO INC.

US Patent


Assay Description
IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen™ Terbium Labeled TR-FRET assay. Kinase assays were performed in 1...


US Patent US10807994 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%