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Patent code US10815206

Compile Data Set for Download or QSAR
Found 95 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470273
PNG
(US10815206, Compound I-58)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O)C#CC1(O)COC1
PDB

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n/an/a 11n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470252
PNG
(US10815206, Compound I-29)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2ncn(Cc3ccccc3)n2)C1=O)C#CC(C)(C)O
Show InChI InChI=1S/C25H25N5O4/c1-25(2,33)12-11-17-9-10-21-20(13-17)29(3)24(32)19(15-34-21)27-23(31)22-26-16-30(28-22)14-18-7-5-4-6-8-18/h4-10,13,16,19,33H,14-15H2,1-3H3,(H,27,31)/t19-/m0/s1
PDB

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n/an/a 12.4n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470256
PNG
(US10815206, Compound I-33)
Show SMILES CN1c2cc(CCC(=O)N3CCCC3)ccc2OC[C@H](NC(=O)c2ncn(Cc3ccccc3)n2)C1=O
Show InChI InChI=1S/C27H30N6O4/c1-31-22-15-19(10-12-24(34)32-13-5-6-14-32)9-11-23(22)37-17-21(27(31)36)29-26(35)25-28-18-33(30-25)16-20-7-3-2-4-8-20/h2-4,7-9,11,15,18,21H,5-6,10,12-14,16-17H2,1H3,(H,29,35)/t21-/m0/s1
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n/an/a 14.5n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470224
PNG
(US10815206, Compound I-2)
Show SMILES CN1c2cc(CCC(=O)Nc3ccc4[nH]ncc4c3)ccc2OC[C@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)C1=O
PDB

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n/an/a 15.7n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470319
PNG
(US10815206, Compound I-87)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O)C#CC(C)(C)O
Show InChI InChI=1S/C26H25N3O5/c1-26(2,32)12-11-18-9-10-23-22(14-18)29(3)25(31)21(16-33-23)27-24(30)20-15-19(34-28-20)13-17-7-5-4-6-8-17/h4-10,14-15,21,32H,13,16H2,1-3H3,(H,27,30)/t21-/m0/s1
PDB

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n/an/a 18.7n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470279
PNG
(US10815206, Compound I-64)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Oc3ccccc3)n2)C1=O)C#CC(C)(C)O
PDB

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n/an/a 19n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470298
PNG
(US10815206, Compound I-81)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2ccn(Cc3ccccc3)n2)C1=O)C#C
Show InChI InChI=1S/C23H20N4O3/c1-3-16-9-10-21-20(13-16)26(2)23(29)19(15-30-21)24-22(28)18-11-12-27(25-18)14-17-7-5-4-6-8-17/h1,4-13,19H,14-15H2,2H3,(H,24,28)/t19-/m0/s1
PDB

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n/an/a 19n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM464513
PNG
(US10815206, Compound I-1)
Show SMILES COCC(=O)CCc1ccc2OC[C@H](NC(=O)c3n[nH]c(Cc4ccccc4)n3)C(=O)N(C)c2c1
PDB

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n/an/a 19n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470228
PNG
(US10815206, Compound I-5)
Show SMILES CCOC(=O)CCc1ccc2OC[C@H](NC(=O)c3ncn(Cc4ccccc4F)n3)C(=O)N(C)c2c1
Show InChI InChI=1S/C25H26FN5O5/c1-3-35-22(32)11-9-16-8-10-21-20(12-16)30(2)25(34)19(14-36-21)28-24(33)23-27-15-31(29-23)13-17-6-4-5-7-18(17)26/h4-8,10,12,15,19H,3,9,11,13-14H2,1-2H3,(H,28,33)/t19-/m0/s1
PDB

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n/an/a 19.7n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470297
PNG
(US10815206, Compound I-80)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3F)n2)C1=O)C#CC(C)(C)O
PDB

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n/an/a 20.6n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470230
PNG
(US10815206, Compound I-7)
Show SMILES CN1c2cc(CCC(=O)Nc3ccc4[nH]ncc4c3)ccc2OC[C@H](NC(=O)c2ncn(Cc3ccccc3F)n2)C1=O
PDB

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n/an/a 21n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470270
PNG
(US10815206, Compound I-52 | US10815206, Compound I...)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O)C#CC1(O)CCCC1
PDB

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n/an/a 21.5n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470289
PNG
(US10815206, Compound I-71)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)o2)C1=O)C#CC(C)(C)O
Show InChI InChI=1S/C25H24N4O5/c1-25(2,32)12-11-17-9-10-20-19(13-17)29(3)24(31)18(15-33-20)26-22(30)23-28-27-21(34-23)14-16-7-5-4-6-8-16/h4-10,13,18,32H,14-15H2,1-3H3,(H,26,30)/t18-/m0/s1
PDB

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n/an/a 21.7n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470255
PNG
(US10815206, Compound I-32)
Show SMILES CN1c2cc(CCC(N)=O)ccc2OC[C@H](NC(=O)c2ncn(Cc3ccccc3)n2)C1=O
Show InChI InChI=1S/C23H24N6O4/c1-28-18-11-15(8-10-20(24)30)7-9-19(18)33-13-17(23(28)32)26-22(31)21-25-14-29(27-21)12-16-5-3-2-4-6-16/h2-7,9,11,14,17H,8,10,12-13H2,1H3,(H2,24,30)(H,26,31)/t17-/m0/s1
PDB

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n/an/a 21.9n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470283
PNG
(US10815206, Compound I-68)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2cc(Oc3ccccc3)ccn2)C1=O)C#CC(C)(C)O
Show InChI InChI=1S/C27H25N3O5/c1-27(2,33)13-11-18-9-10-24-23(15-18)30(3)26(32)22(17-34-24)29-25(31)21-16-20(12-14-28-21)35-19-7-5-4-6-8-19/h4-10,12,14-16,22,33H,17H2,1-3H3,(H,29,31)/t22-/m0/s1
PDB

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n/an/a 22.2n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470258
PNG
(US10815206, Compound I-35)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O)C#CCCCO
PDB

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n/an/a 22.3n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470269
PNG
(US10815206, Compound I-50)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O)C#CC1(O)CCC1
PDB

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n/an/a 23.4n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470270
PNG
(US10815206, Compound I-52 | US10815206, Compound I...)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O)C#CC1(O)CCCC1
PDB

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n/an/a 24.9n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470311
PNG
(US10815206, Compound I-82)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3C)n2)C1=O)C#CC(C)(C)O
PDB

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n/an/a 25.5n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470271
PNG
(US10815206, Compound I-54)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O)C#CC1(O)CCOCC1
PDB

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n/an/a 26.9n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470327
PNG
(US10815206, Compound I-95)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O)C#CCN1CCCC1
PDB

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n/an/a 27.1n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470284
PNG
(US10815206, Compound I-69)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)C1=O)C#CC(C)(C)O
PDB

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n/an/a 28.6n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470253
PNG
(US10815206, Compound I-30 | US10815206, Compound I...)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O)C#CC(C)(C)O
PDB

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n/an/a 30.3n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470328
PNG
(US10815206, Compound I-96)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O)C#CCN1CCOCC1
PDB

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n/an/a 31.7n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470334
PNG
(US10815206, Compound I-51)
Show SMILES CN1c2cc(ccc2OC[C@@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O)C#CC1(O)CCC1
PDB

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n/an/a 31.7n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470294
PNG
(US10815206, Compound I-77)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2ccn(Cc3ccccc3)n2)C1=O)C#CC(C)(C)O
Show InChI InChI=1S/C26H26N4O4/c1-26(2,33)13-11-18-9-10-23-22(15-18)29(3)25(32)21(17-34-23)27-24(31)20-12-14-30(28-20)16-19-7-5-4-6-8-19/h4-10,12,14-15,21,33H,16-17H2,1-3H3,(H,27,31)/t21-/m0/s1
PDB

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n/an/a 32.7n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470326
PNG
(US10815206, Compound I-94)
Show SMILES CN1c2cc(\C=C(/Cl)C(C)(C)O)ccc2OC[C@H](NC(=O)c2ncn(Cc3ccccc3)n2)C1=O
Show InChI InChI=1S/C25H26ClN5O4/c1-25(2,34)21(26)12-17-9-10-20-19(11-17)30(3)24(33)18(14-35-20)28-23(32)22-27-15-31(29-22)13-16-7-5-4-6-8-16/h4-12,15,18,34H,13-14H2,1-3H3,(H,28,32)/b21-12-/t18-/m0/s1
PDB

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n/an/a 33.3n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470254
PNG
(US10815206, Compound I-31)
Show SMILES CN1c2cc(CCC(N)=O)ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O
PDB

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n/an/a 33.4n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470295
PNG
(US10815206, Compound I-78)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3cccc(F)c3)n2)C1=O)C#CC(C)(C)O
PDB

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n/an/a 33.4n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470336
PNG
(US10815206, Compound I-55)
Show SMILES CN1c2cc(ccc2OC[C@@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O)C#CC1(O)CCOCC1
PDB

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n/an/a 33.7n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470253
PNG
(US10815206, Compound I-30 | US10815206, Compound I...)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O)C#CC(C)(C)O
PDB

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n/an/a 33.8n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470266
PNG
(US10815206, Compound I-44)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O)C#CCCOc1cccc2ncccc12
PDB

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n/an/a 34n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470335
PNG
(US10815206, Compound I-53)
Show SMILES CN1c2cc(ccc2OC[C@@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O)C#CC1(O)CCCC1
PDB

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n/an/a 34n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470296
PNG
(US10815206, Compound I-79)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3ccc(F)cc3)n2)C1=O)C#CC(C)(C)O
PDB

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n/an/a 34.7n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470246
PNG
(US10815206, Compound I-23)
Show SMILES CN1c2cc(\C=C\C(=O)NC3CC3)ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O
PDB

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n/an/a 35.2n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470253
PNG
(US10815206, Compound I-30 | US10815206, Compound I...)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O)C#CC(C)(C)O
PDB

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n/an/a 35.5n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470262
PNG
(US10815206, Compound I-39)
Show SMILES CN1c2cc(CN3CCN4N=C(NC4C3)C(F)(F)F)ccc2OC[C@H](NC(=O)c2ncn(Cc3ccccc3)n2)C1=O
Show InChI InChI=1S/C27H28F3N9O3/c1-36-20-11-18(12-37-9-10-39-22(14-37)33-26(35-39)27(28,29)30)7-8-21(20)42-15-19(25(36)41)32-24(40)23-31-16-38(34-23)13-17-5-3-2-4-6-17/h2-8,11,16,19,22H,9-10,12-15H2,1H3,(H,32,40)(H,33,35)/t19-,22?/m0/s1
PDB

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n/an/a 36.4n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470251
PNG
(US10815206, Compound I-28)
Show SMILES CN1c2cc(CCC(C)(C)O)ccc2OC[C@H](NC(=O)c2ncn(Cc3ccccc3)n2)C1=O
Show InChI InChI=1S/C25H29N5O4/c1-25(2,33)12-11-17-9-10-21-20(13-17)29(3)24(32)19(15-34-21)27-23(31)22-26-16-30(28-22)14-18-7-5-4-6-8-18/h4-10,13,16,19,33H,11-12,14-15H2,1-3H3,(H,27,31)/t19-/m0/s1
PDB

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n/an/a 37.5n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470225
PNG
(US10815206, Compound I-3)
Show SMILES CN1c2cc(CCC(=O)Nc3ccc4cnnc4c3)ccc2OC[C@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)C1=O
PDB

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n/an/a 40.2n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470253
PNG
(US10815206, Compound I-30 | US10815206, Compound I...)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O)C#CC(C)(C)O
PDB

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n/an/a 40.2n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470282
PNG
(US10815206, Compound I-67)
Show SMILES CN1c2ccc(CN3CCn4nc(nc4C3)C(F)(F)F)cc2OC[C@H](NC(=O)c2ncn(Cc3c(Cl)cccc3Cl)n2)C1=O
Show InChI InChI=1S/C27H24Cl2F3N9O3/c1-38-20-6-5-15(10-39-7-8-41-22(12-39)35-26(37-41)27(30,31)32)9-21(20)44-13-19(25(38)43)34-24(42)23-33-14-40(36-23)11-16-17(28)3-2-4-18(16)29/h2-6,9,14,19H,7-8,10-13H2,1H3,(H,34,42)/t19-/m0/s1
PDB

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n/an/a 41.5n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470317
PNG
(US10815206, Compound I-85)
Show SMILES CC(C)Cn1cnc(n1)C(=O)N[C@H]1COc2ccc(cc2N(C)C1=O)C#CC(C)(C)O
Show InChI InChI=1S/C22H27N5O4/c1-14(2)11-27-13-23-19(25-27)20(28)24-16-12-31-18-7-6-15(8-9-22(3,4)30)10-17(18)26(5)21(16)29/h6-7,10,13-14,16,30H,11-12H2,1-5H3,(H,24,28)/t16-/m0/s1
PDB

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n/an/a 42.3n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470233
PNG
(US10815206, Compound I-10)
Show SMILES CN1c2cc(CCC(=O)N3CCCC3)ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O
PDB

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n/an/a 42.9n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470290
PNG
(US10815206, Compound I-73)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)C1=O)C#CC1(O)COC1
PDB

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n/an/a 42.9n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470267
PNG
(US10815206, Compound I-46)
Show SMILES CN1c2cc(CN3CCn4c(C3)nnc4C(F)(F)F)ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O
PDB

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n/an/a 43.7n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470316
PNG
(US10815206, Compound I-84)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2ncn(Cc3c(C)cccc3C)n2)C1=O)C#CC(C)(C)O
Show InChI InChI=1S/C27H29N5O4/c1-17-7-6-8-18(2)20(17)14-32-16-28-24(30-32)25(33)29-21-15-36-23-10-9-19(11-12-27(3,4)35)13-22(23)31(5)26(21)34/h6-10,13,16,21,35H,14-15H2,1-5H3,(H,29,33)/t21-/m0/s1
PDB

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n/an/a 44.1n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470293
PNG
(US10815206, Compound I-76)
Show SMILES COC(=O)C(C)(C)C#Cc1ccc2OC[C@H](NC(=O)c3n[nH]c(Cc4ccccc4)n3)C(=O)N(C)c2c1
PDB

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n/an/a 44.9n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470330
PNG
(US10815206, Compound I-42)
Show SMILES CN1c2cc(ccc2OC[C@@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O)C#CCCOc1ccc2cccnc2c1
PDB

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n/an/a 47.7n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470245
PNG
(US10815206, Compound I-22)
Show SMILES CN1c2cc(\C=C\C(=O)N3CCCC3)ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O
PDB

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n/an/a 48n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470257
PNG
(US10815206, Compound I-34)
Show SMILES CN1c2cc(CCC(=O)N3CCCC3)ccc2OC[C@H](NC(=O)c2nnn(Cc3cc(F)ccc3F)n2)C1=O
Show InChI InChI=1S/C26H27F2N7O4/c1-33-21-12-16(5-9-23(36)34-10-2-3-11-34)4-8-22(21)39-15-20(26(33)38)29-25(37)24-30-32-35(31-24)14-17-13-18(27)6-7-19(17)28/h4,6-8,12-13,20H,2-3,5,9-11,14-15H2,1H3,(H,29,37)/t20-/m0/s1
PDB

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n/an/a 49.2n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470248
PNG
(US10815206, Compound I-25)
Show SMILES CN1c2cc(CN3CCn4ncnc4C3)ccc2OC[C@H](NC(=O)c2ncn(Cc3ccccc3)n2)C1=O
Show InChI InChI=1S/C26H27N9O3/c1-32-21-11-19(12-33-9-10-35-23(14-33)27-16-29-35)7-8-22(21)38-15-20(26(32)37)30-25(36)24-28-17-34(31-24)13-18-5-3-2-4-6-18/h2-8,11,16-17,20H,9-10,12-15H2,1H3,(H,30,36)/t20-/m0/s1
PDB

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n/an/a 51n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470291
PNG
(US10815206, Compound I-74)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)C1=O)C#C[C@@]1(O)COC2[C@H](COC12)OC(=O)c1ccccc1
PDB

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n/an/a 51.8n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470235
PNG
(US10815206, Compound I-12)
Show SMILES CN1c2cc(CCC(=O)Nc3ccc4cccnc4c3)ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O
PDB

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n/an/a 52n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470321
PNG
(US10815206, Compound I-89)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2n[nH]c(Cc3ccccc3F)n2)C1=O)C#CC(C)(C)C
PDB

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n/an/a 52.7n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470231
PNG
(US10815206, Compound I-8)
Show SMILES CCOC(=O)CCc1ccc2OC[C@H](NC(=O)c3ncn(Cc4c(Cl)cccc4Cl)n3)C(=O)N(C)c2c1
Show InChI InChI=1S/C25H25Cl2N5O5/c1-3-36-22(33)10-8-15-7-9-21-20(11-15)31(2)25(35)19(13-37-21)29-24(34)23-28-14-32(30-23)12-16-17(26)5-4-6-18(16)27/h4-7,9,11,14,19H,3,8,10,12-13H2,1-2H3,(H,29,34)/t19-/m0/s1
PDB

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n/an/a 52.9n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470236
PNG
(US10815206, Compound I-13)
Show SMILES CN1c2cc(CCC(=O)NC3CC3)ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O
PDB

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n/an/a 53.9n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470292
PNG
(US10815206, Compound I-75)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)C1=O)C#C[C@@]1(O)COC2[C@@H](O)COC12
PDB

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n/an/a 54.6n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470260
PNG
(US10815206, Compound I-37)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2ncn(Cc3ccccc3)n2)C1=O)C#CCCOc1ccc2ncccc2c1
Show InChI InChI=1S/C33H28N6O4/c1-38-29-18-23(8-5-6-17-42-26-13-14-27-25(19-26)11-7-16-34-27)12-15-30(29)43-21-28(33(38)41)36-32(40)31-35-22-39(37-31)20-24-9-3-2-4-10-24/h2-4,7,9-16,18-19,22,28H,6,17,20-21H2,1H3,(H,36,40)/t28-/m0/s1
PDB

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n/an/a 56.5n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470227
PNG
(US10815206, Compound I-4)
Show SMILES COC1Cc2cccc(NC(=O)CCc3ccc4OC[C@H](NC(=O)c5n[nH]c(Cc6ccccc6)n5)C(=O)N(C)c4c3)c2CC1OC
PDB

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n/an/a 56.8n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470234
PNG
(US10815206, Compound I-11)
Show SMILES CN1c2cc(CCC(=O)N3CCOCC3)ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O
PDB

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n/an/a 57.1n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470274
PNG
(US10815206, Compound I-59)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O)C#CC(C)=C
PDB

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n/an/a 57.9n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470247
PNG
(US10815206, Compound I-24)
Show SMILES CN1c2cc(CN3CCn4ncnc4C3)ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O
PDB

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n/an/a 59.2n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470333
PNG
(US10815206, Compound I-49)
Show SMILES CN1c2cc(ccc2OC[C@@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O)C#CC(C)(C)C
PDB

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n/an/a 60.4n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470268
PNG
(US10815206, Compound I-48)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O)C#CC(C)(C)C
PDB

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n/an/a 62.4n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470280
PNG
(US10815206, Compound I-65)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3c(Cl)cccc3Cl)n2)C1=O)C#CC(C)(C)O
PDB

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n/an/a 63.9n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470325
PNG
(US10815206, Compound I-93)
Show SMILES CC(=C)C#Cc1ccc2OC[C@H](NC(=O)c3ncn(Cc4ccccc4)n3)C(=O)Nc2c1
Show InChI InChI=1S/C24H21N5O3/c1-16(2)8-9-17-10-11-21-19(12-17)26-23(30)20(14-32-21)27-24(31)22-25-15-29(28-22)13-18-6-4-3-5-7-18/h3-7,10-12,15,20H,1,13-14H2,2H3,(H,26,30)(H,27,31)/t20-/m0/s1
PDB

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n/an/a 64.1n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470275
PNG
(US10815206, Compound I-60)
Show SMILES CC(C)CCc1ccc2OC[C@H](NC(=O)c3nnc(Cc4ccccc4)n3)C(=O)N(C)c2c1
PDB

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n/an/a 64.4n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470276
PNG
(US10815206, Compound I-61)
Show SMILES COC(C)(C)C#Cc1ccc2OC[C@H](NC(=O)c3nnc(Cc4ccccc4)n3)C(=O)N(C)c2c1
PDB

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n/an/a 65.4n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470249
PNG
(US10815206, Compound I-26)
Show SMILES CN1c2cc(CCC(=O)NC3CC3)ccc2OC[C@H](NC(=O)c2ncn(Cc3ccccc3)n2)C1=O
Show InChI InChI=1S/C26H28N6O4/c1-31-21-13-17(8-12-23(33)28-19-9-10-19)7-11-22(21)36-15-20(26(31)35)29-25(34)24-27-16-32(30-24)14-18-5-3-2-4-6-18/h2-7,11,13,16,19-20H,8-10,12,14-15H2,1H3,(H,28,33)(H,29,34)/t20-/m0/s1
PDB

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n/an/a 65.6n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470315
PNG
(US10815206, Compound I-83)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3ccc(cc3)-c3ccccc3)n2)C1=O)C#CC(C)(C)O
PDB

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n/an/a 66.4n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470261
PNG
(US10815206, Compound I-38)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O)C#CCCOc1ccc2ncccc2c1
PDB

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n/an/a 68n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470332
PNG
(US10815206, Compound I-47)
Show SMILES CN1c2cc(CN3CCn4c(C3)nnc4C(F)(F)F)ccc2OC[C@@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O
PDB

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n/an/a 68.3n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470229
PNG
(US10815206, Compound I-6)
Show SMILES CN1c2cc(CCC(O)=O)ccc2OC[C@H](NC(=O)c2ncn(Cc3ccccc3F)n2)C1=O
Show InChI InChI=1S/C23H22FN5O5/c1-28-18-10-14(7-9-20(30)31)6-8-19(18)34-12-17(23(28)33)26-22(32)21-25-13-29(27-21)11-15-4-2-3-5-16(15)24/h2-6,8,10,13,17H,7,9,11-12H2,1H3,(H,26,32)(H,30,31)/t17-/m0/s1
PDB

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n/an/a 72.4n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470237
PNG
(US10815206, Compound I-14)
Show SMILES CN1c2cc(CCCO)ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O
PDB

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n/an/a 73n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470320
PNG
(US10815206, Compound I-88)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)C1=O)C#Cc1ccc2CCNCc2c1
PDB

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n/an/a 73.8n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470244
PNG
(US10815206, Compound I-21)
Show SMILES CN1c2cc(CN3CCN(CC3)c3ccncc3)ccc2OC[C@H](NC(=O)c2nnc(Cc3c(Cl)cccc3Cl)n2)C1=O
PDB

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n/an/a 77n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470281
PNG
(US10815206, Compound I-66)
Show SMILES CN1c2ccc(CN3CCn4nc(nc4C3)C(F)(F)F)cc2OC[C@H](NC(=O)c2nnc(Cc3c(Cl)cccc3Cl)n2)C1=O
PDB

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n/an/a 79.4n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470264
PNG
(US10815206, Compound I-41)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O)C#CCCOc1ccc2cccnc2c1
PDB

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n/an/a 80n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470331
PNG
(US10815206, Compound I-45)
Show SMILES CN1c2cc(ccc2OC[C@@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O)C#CCCOc1cccc2ncccc12
PDB

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n/an/a 82.5n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470265
PNG
(US10815206, Compound I-43)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3ccc(F)cc3F)n2)C1=O)C#CC(C)(C)O
PDB

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n/an/a 85.4n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470329
PNG
(US10815206, Compound I-97)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O)C#C[Si](C)(C)C
PDB

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n/an/a 85.8n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470263
PNG
(US10815206, Compound I-40)
Show SMILES CN1c2cc(CN3CCN4N=C(NC4C3)C(F)(F)F)ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O
PDB

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n/an/a 88.7n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470238
PNG
(US10815206, Compound I-15)
Show SMILES CN1c2cc(CCCCO)ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O
PDB

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n/an/a 136n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470242
PNG
(US10815206, Compound I-19)
Show SMILES CN1c2cc(CCC(=O)NC3CC3)ccc2OC[C@H](NC(=O)c2ncn(Cc3c(Cl)cccc3Cl)n2)C1=O
Show InChI InChI=1S/C26H26Cl2N6O4/c1-33-21-11-15(6-10-23(35)30-16-7-8-16)5-9-22(21)38-13-20(26(33)37)31-25(36)24-29-14-34(32-24)12-17-18(27)3-2-4-19(17)28/h2-5,9,11,14,16,20H,6-8,10,12-13H2,1H3,(H,30,35)(H,31,36)/t20-/m0/s1
PDB

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n/an/a 146n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470243
PNG
(US10815206, Compound I-20)
Show SMILES CN1c2cc(CN3CCN(CC3)c3ccncc3)ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O
PDB

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n/an/a 153n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470250
PNG
(US10815206, Compound I-27)
Show SMILES CN1c2cc(CCC(=O)NC3CC3)ccc2OC[C@H](NC(=O)c2ncn(Cc3ccc(F)cc3F)n2)C1=O
Show InChI InChI=1S/C26H26F2N6O4/c1-33-21-10-15(3-9-23(35)30-18-6-7-18)2-8-22(21)38-13-20(26(33)37)31-25(36)24-29-14-34(32-24)12-16-4-5-17(27)11-19(16)28/h2,4-5,8,10-11,14,18,20H,3,6-7,9,12-13H2,1H3,(H,30,35)(H,31,36)/t20-/m0/s1
PDB

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n/an/a 158n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470241
PNG
(US10815206, Compound I-18)
Show SMILES CN1c2cc(CCC(=O)N3CCCC3)ccc2OC[C@H](NC(=O)c2ncn(Cc3c(Cl)cccc3Cl)n2)C1=O
Show InChI InChI=1S/C27H28Cl2N6O4/c1-33-22-13-17(8-10-24(36)34-11-2-3-12-34)7-9-23(22)39-15-21(27(33)38)31-26(37)25-30-16-35(32-25)14-18-19(28)5-4-6-20(18)29/h4-7,9,13,16,21H,2-3,8,10-12,14-15H2,1H3,(H,31,37)/t21-/m0/s1
PDB

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n/an/a 164n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470232
PNG
(US10815206, Compound I-9)
Show SMILES CN1c2cc(CCC(O)=O)ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O
PDB

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n/an/a 189n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470322
PNG
(US10815206, Compound I-90)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2n[nH]c(Cc3c(C)cccc3C)n2)C1=O)C#CC(C)(C)C
PDB

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n/an/a 365n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470323
PNG
(US10815206, Compound I-91)
Show SMILES CCN1c2cc(ccc2OC[C@H](NC(=O)c2ncn(Cc3ccccc3)n2)C1=O)C#CC(C)(C)O
Show InChI InChI=1S/C26H27N5O4/c1-4-31-21-14-18(12-13-26(2,3)34)10-11-22(21)35-16-20(25(31)33)28-24(32)23-27-17-30(29-23)15-19-8-6-5-7-9-19/h5-11,14,17,20,34H,4,15-16H2,1-3H3,(H,28,32)/t20-/m0/s1
PDB

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n/an/a 388n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470240
PNG
(US10815206, Compound I-17)
Show SMILES CN1c2cc(CCCCNc3ccccn3)ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O
PDB

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n/an/a 491n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470253
PNG
(US10815206, Compound I-30 | US10815206, Compound I...)
Show SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O)C#CC(C)(C)O
PDB

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n/an/a 616n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470324
PNG
(US10815206, Compound I-92)
Show SMILES CCN1c2cc(ccc2OC[C@H](NC(=O)c2ncn(Cc3cccc(F)c3)n2)C1=O)C#CC(C)(C)O
Show InChI InChI=1S/C26H26FN5O4/c1-4-32-21-13-17(10-11-26(2,3)35)8-9-22(21)36-15-20(25(32)34)29-24(33)23-28-16-31(30-23)14-18-6-5-7-19(27)12-18/h5-9,12-13,16,20,35H,4,14-15H2,1-3H3,(H,29,33)/t20-/m0/s1
PDB

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n/an/a 932n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470288
PNG
(US10815206, Compound I-70)
Show SMILES CN1c2cc(ccc2OC[C@@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)C1=O)C#CC(C)(C)O
PDB

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n/an/a 1.16E+3n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)


(Homo sapiens (Human))
BDBM470239
PNG
(US10815206, Compound I-16)
Show SMILES CN1c2cc(CCCCOCc3ccccn3)ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O
PDB

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n/an/a 1.63E+3n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
A 500 ml stock volume of 5 Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...


US Patent US10815206 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%