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Patent code US10815229

Compile Data Set for Download or QSAR

Found 1146 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ep nav1.6


(Homo sapiens (Human))
BDBM374028
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H23F2N5O2S2/c1-14-18(27(2)16-8-9-28(12-16)11-15-6-4-3-5-7-15)10-17(22)20(19(14)23)32(29,30)26-21-24-13-25-31-21/h3-7,10,13,16H,8-9,11-12H2,1-2H3,(H,24,25,26)/t16-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
ep nav1.6


(Homo sapiens (Human))
BDBM374029
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN([C@H]1CCN(Cc2cccc(C)n2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H24F2N6O2S2/c1-13-5-4-6-15(26-13)10-29-8-7-16(11-29)28(3)18-9-17(22)20(19(23)14(18)2)33(30,31)27-21-24-12-25-32-21/h4-6,9,12,16H,7-8,10-11H2,1-3H3,(H,24,25,27)/t16-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
ep nav1.6


(Homo sapiens (Human))
BDBM374015
PNG
((R)-2,6-difluoro-3-methyl-4-((1-(1-phenylethyl)pip...)
Show SMILES C[C@@H](N1CCC(CC1)Oc1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1)c1ccccc1
Show InChI InChI=1S/C23H25F2N3O3S2/c1-15-20(12-19(24)23(22(15)25)33(29,30)27-21-13-32-14-26-21)31-18-8-10-28(11-9-18)16(2)17-6-4-3-5-7-17/h3-7,12-14,16,18,27H,8-11H2,1-2H3/t16-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM374015
PNG
((R)-2,6-difluoro-3-methyl-4-((1-(1-phenylethyl)pip...)
Show SMILES C[C@@H](N1CCC(CC1)Oc1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1)c1ccccc1
Show InChI InChI=1S/C23H25F2N3O3S2/c1-15-20(12-19(24)23(22(15)25)33(29,30)27-21-13-32-14-26-21)31-18-8-10-28(11-9-18)16(2)17-6-4-3-5-7-17/h3-7,12-14,16,18,27H,8-11H2,1-2H3/t16-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
ep nav1.6


(Homo sapiens (Human))
BDBM373891
PNG
((S)-4-((1-benzyl-3-methylpyrrolidin-3-yl)oxy)-2,6-...)
Show SMILES Cc1c(F)c(c(F)cc1O[C@@]1(C)CCN(Cc2ccccc2)C1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H23F2N3O3S2/c1-15-18(30-22(2)8-9-27(13-22)11-16-6-4-3-5-7-16)10-17(23)21(20(15)24)32(28,29)26-19-12-31-14-25-19/h3-7,10,12,14,26H,8-9,11,13H2,1-2H3/t22-/m0/s1
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n/an/a 8n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM373956
PNG
(4-((1-benzylpiperidin-4-yl)oxy)-2,6-difluoro-3-met...)
Show SMILES Cc1c(F)c(c(F)cc1OC1CCN(Cc2ccccc2)CC1)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C22H23F2N3O3S2/c1-15-19(30-17-7-10-27(11-8-17)14-16-5-3-2-4-6-16)13-18(23)21(20(15)24)32(28,29)26-22-25-9-12-31-22/h2-6,9,12-13,17H,7-8,10-11,14H2,1H3,(H,25,26)
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n/an/a 9n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM373891
PNG
((S)-4-((1-benzyl-3-methylpyrrolidin-3-yl)oxy)-2,6-...)
Show SMILES Cc1c(F)c(c(F)cc1O[C@@]1(C)CCN(Cc2ccccc2)C1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H23F2N3O3S2/c1-15-18(30-22(2)8-9-27(13-22)11-16-6-4-3-5-7-16)10-17(23)21(20(15)24)32(28,29)26-19-12-31-14-25-19/h3-7,10,12,14,26H,8-9,11,13H2,1-2H3/t22-/m0/s1
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n/an/a 9n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM374028
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H23F2N5O2S2/c1-14-18(27(2)16-8-9-28(12-16)11-15-6-4-3-5-7-15)10-17(22)20(19(14)23)32(29,30)26-21-24-13-25-31-21/h3-7,10,13,16H,8-9,11-12H2,1-2H3,(H,24,25,26)/t16-/m0/s1
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n/an/a 9n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM374029
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN([C@H]1CCN(Cc2cccc(C)n2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H24F2N6O2S2/c1-13-5-4-6-15(26-13)10-29-8-7-16(11-29)28(3)18-9-17(22)20(19(23)14(18)2)33(30,31)27-21-24-12-25-32-21/h4-6,9,12,16H,7-8,10-11H2,1-3H3,(H,24,25,27)/t16-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
ep nav1.6


(Homo sapiens (Human))
BDBM470683
PNG
((S)-2,6-difluoro-3-methyl-4-(methyl(1-((6-methylpy...)
Show SMILES CN([C@H]1CCN(Cc2cccc(C)n2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H25F2N5O2S2/c1-14-5-4-6-16(26-14)10-29-8-7-17(11-29)28(3)19-9-18(23)22(21(24)15(19)2)33(30,31)27-20-12-32-13-25-20/h4-6,9,12-13,17,27H,7-8,10-11H2,1-3H3/t17-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
ep nav1.6


(Homo sapiens (Human))
BDBM374012
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1ccsn1
Show InChI InChI=1S/C22H24F2N4O2S2/c1-15-19(27(2)17-8-10-28(14-17)13-16-6-4-3-5-7-16)12-18(23)22(21(15)24)32(29,30)26-20-9-11-31-25-20/h3-7,9,11-12,17H,8,10,13-14H2,1-2H3,(H,25,26)/t17-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
ep nav1.6


(Homo sapiens (Human))
BDBM444553
PNG
((S)-3-chloro-2,6-difluoro-4-(methyl (1-((6-methylp...)
Show SMILES CN([C@H]1CCN(Cc2cccc(C)n2)C1)c1cc(F)c(c(F)c1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H21ClF2N6O2S2/c1-12-4-3-5-13(26-12)9-29-7-6-14(10-29)28(2)16-8-15(22)19(18(23)17(16)21)33(30,31)27-20-24-11-25-32-20/h3-5,8,11,14H,6-7,9-10H2,1-2H3,(H,24,25,27)/t14-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM373764
PNG
((S)-3-chloro-4-((1-(3-(difluoromethyl)benzyl)pyrro...)
Show SMILES CN([C@H]1CCN(Cc2cccc(c2)C(F)F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H22ClF2N5O2S2/c1-28(16-7-8-29(12-16)11-14-3-2-4-15(9-14)20(23)24)19-6-5-17(10-18(19)22)33(30,31)27-21-25-13-26-32-21/h2-6,9-10,13,16,20H,7-8,11-12H2,1H3,(H,25,26,27)/t16-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
ep nav1.6


(Homo sapiens (Human))
BDBM470682
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H24F2N4O2S2/c1-15-19(27(2)17-8-9-28(12-17)11-16-6-4-3-5-7-16)10-18(23)22(21(15)24)32(29,30)26-20-13-31-14-25-20/h3-7,10,13-14,17,26H,8-9,11-12H2,1-2H3/t17-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM374014
PNG
((R)-2-fluoro-5-methyl-4-(methyl(1-(1-phenylethyl)p...)
Show SMILES C[C@@H](N1CCC(CC1)N(C)c1cc(F)c(cc1C)S(=O)(=O)Nc1cscn1)c1ccccc1
Show InChI InChI=1S/C24H29FN4O2S2/c1-17-13-23(33(30,31)27-24-15-32-16-26-24)21(25)14-22(17)28(3)20-9-11-29(12-10-20)18(2)19-7-5-4-6-8-19/h4-8,13-16,18,20,27H,9-12H2,1-3H3/t18-/m1/s1
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n/an/a 21n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM373768
PNG
((S)-3-chloro-4-((1-(2-fluoro-5-methylbenzyl)pyrrol...)
Show SMILES CN([C@H]1CCN(Cc2cc(C)ccc2F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H23ClFN5O2S2/c1-14-3-5-19(23)15(9-14)11-28-8-7-16(12-28)27(2)20-6-4-17(10-18(20)22)32(29,30)26-21-24-13-25-31-21/h3-6,9-10,13,16H,7-8,11-12H2,1-2H3,(H,24,25,26)/t16-/m0/s1
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n/an/a 21n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM373763
PNG
((S)-3-chloro-4-((1-(3-chlorobenzyl)pyrrolidin-3-yl...)
Show SMILES CN([C@H]1CCN(Cc2cccc(Cl)c2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H21Cl2N5O2S2/c1-26(16-7-8-27(12-16)11-14-3-2-4-15(21)9-14)19-6-5-17(10-18(19)22)31(28,29)25-20-23-13-24-30-20/h2-6,9-10,13,16H,7-8,11-12H2,1H3,(H,23,24,25)/t16-/m0/s1
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n/an/a 21n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM373957
PNG
((S)-2,6-difluoro-3-methyl-4-(methyl(1-((6-(trifluo...)
Show SMILES CN([C@H]1CCN(Cc2cccc(n2)C(F)(F)F)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H22F5N5O2S2/c1-13-17(8-16(23)21(20(13)24)36(33,34)30-19-11-35-12-28-19)31(2)15-6-7-32(10-15)9-14-4-3-5-18(29-14)22(25,26)27/h3-5,8,11-12,15,30H,6-7,9-10H2,1-2H3/t15-/m0/s1
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n/an/a 24n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
ep nav1.6


(Homo sapiens (Human))
BDBM444506
PNG
(4-((trans-1-benzyl-4-methylpyrrolidin-3-yl)amino)-...)
Show SMILES C[C@H]1CN(Cc2ccccc2)C[C@@H]1Nc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C21H23ClN4O2S2/c1-15-12-26(13-16-5-3-2-4-6-16)14-20(15)24-19-8-7-17(11-18(19)22)30(27,28)25-21-23-9-10-29-21/h2-11,15,20,24H,12-14H2,1H3,(H,23,25)/t15-,20-/m0/s1
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n/an/a 25n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM470683
PNG
((S)-2,6-difluoro-3-methyl-4-(methyl(1-((6-methylpy...)
Show SMILES CN([C@H]1CCN(Cc2cccc(C)n2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H25F2N5O2S2/c1-14-5-4-6-16(26-14)10-29-8-7-17(11-29)28(3)19-9-18(23)22(21(24)15(19)2)33(30,31)27-20-12-32-13-25-20/h4-6,9,12-13,17,27H,7-8,10-11H2,1-3H3/t17-/m0/s1
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n/an/a 26n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
ep nav1.6


(Homo sapiens (Human))
BDBM374010
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2-f...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(cc1C)S(=O)(=O)Nc1ccsn1
Show InChI InChI=1S/C22H25FN4O2S2/c1-16-12-21(31(28,29)25-22-9-11-30-24-22)19(23)13-20(16)26(2)18-8-10-27(15-18)14-17-6-4-3-5-7-17/h3-7,9,11-13,18H,8,10,14-15H2,1-2H3,(H,24,25)/t18-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
ep nav1.6


(Homo sapiens (Human))
BDBM373764
PNG
((S)-3-chloro-4-((1-(3-(difluoromethyl)benzyl)pyrro...)
Show SMILES CN([C@H]1CCN(Cc2cccc(c2)C(F)F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H22ClF2N5O2S2/c1-28(16-7-8-29(12-16)11-14-3-2-4-15(9-14)20(23)24)19-6-5-17(10-18(19)22)33(30,31)27-21-25-13-26-32-21/h2-6,9-10,13,16,20H,7-8,11-12H2,1H3,(H,25,26,27)/t16-/m0/s1
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n/an/a 29n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM373816
PNG
((S)-3-chloro-4-(methyl(1-(3-methylbenzyl)pyrrolidi...)
Show SMILES CN([C@H]1CCN(Cc2cccc(C)c2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H24ClN5O2S2/c1-15-4-3-5-16(10-15)12-27-9-8-17(13-27)26(2)20-7-6-18(11-19(20)22)31(28,29)25-21-23-14-24-30-21/h3-7,10-11,14,17H,8-9,12-13H2,1-2H3,(H,23,24,25)/t17-/m0/s1
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n/an/a 29n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
ep nav1.6


(Homo sapiens (Human))
BDBM373749
PNG
(4-(((1R,3s,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3...)
Show SMILES Clc1cc(ccc1O[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccccc1)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C23H24ClN3O3S2/c24-21-14-20(32(28,29)26-23-25-10-11-31-23)8-9-22(21)30-19-12-17-6-7-18(13-19)27(17)15-16-4-2-1-3-5-16/h1-5,8-11,14,17-19H,6-7,12-13,15H2,(H,25,26)/t17-,18+,19-
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n/an/a 30n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM373961
PNG
(US10246453, Example 228 | US10815229, Example 228 ...)
Show SMILES Cc1c(F)c(c(F)cc1OC1(C)CCN(Cc2ccccc2)C1)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C22H23F2N3O3S2/c1-15-18(30-22(2)8-10-27(14-22)13-16-6-4-3-5-7-16)12-17(23)20(19(15)24)32(28,29)26-21-25-9-11-31-21/h3-7,9,11-12H,8,10,13-14H2,1-2H3,(H,25,26)
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n/an/a 31n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
ep nav1.6


(Homo sapiens (Human))
BDBM373788
PNG
((R)-3-chloro-4-((1-(1-phenylethyl)piperidin-4-yl)o...)
Show SMILES C[C@@H](N1CCC(CC1)Oc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1)c1ccccc1
Show InChI InChI=1S/C22H24ClN3O3S2/c1-16(17-5-3-2-4-6-17)26-12-9-18(10-13-26)29-21-8-7-19(15-20(21)23)31(27,28)25-22-24-11-14-30-22/h2-8,11,14-16,18H,9-10,12-13H2,1H3,(H,24,25)/t16-/m1/s1
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n/an/a 32n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
ep nav1.6


(Homo sapiens (Human))
BDBM373838
PNG
(4-((1-benzylpiperidin-4-yl)oxy)-3-chloro-2,6-diflu...)
Show SMILES Fc1cc(OC2CCN(Cc3ccccc3)CC2)c(Cl)c(F)c1S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C21H20ClF2N3O3S2/c22-19-17(30-15-6-8-27(9-7-15)11-14-4-2-1-3-5-14)10-16(23)21(20(19)24)32(28,29)26-18-12-31-13-25-18/h1-5,10,12-13,15,26H,6-9,11H2
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n/an/a 34n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
ep nav1.6


(Homo sapiens (Human))
BDBM373761
PNG
((S)-3-chloro-4-((1-(3-(difluoromethyl)benzyl)pyrro...)
Show SMILES CN([C@H]1CCN(Cc2cccc(c2)C(F)F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C22H23ClF2N4O2S2/c1-28(17-7-9-29(14-17)13-15-3-2-4-16(11-15)21(24)25)20-6-5-18(12-19(20)23)33(30,31)27-22-26-8-10-32-22/h2-6,8,10-12,17,21H,7,9,13-14H2,1H3,(H,26,27)/t17-/m0/s1
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n/an/a 36n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
ep nav1.6


(Homo sapiens (Human))
BDBM373816
PNG
((S)-3-chloro-4-(methyl(1-(3-methylbenzyl)pyrrolidi...)
Show SMILES CN([C@H]1CCN(Cc2cccc(C)c2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H24ClN5O2S2/c1-15-4-3-5-16(10-15)12-27-9-8-17(13-27)26(2)20-7-6-18(11-19(20)22)31(28,29)25-21-23-14-24-30-21/h3-7,10-11,14,17H,8-9,12-13H2,1-2H3,(H,23,24,25)/t17-/m0/s1
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n/an/a 36n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
ep nav1.6


(Homo sapiens (Human))
BDBM374016
PNG
((R)-2,6-difluoro-3-methyl-4-((1-(1-phenylethyl)pip...)
Show SMILES C[C@@H](N1CCC(CC1)Oc1cc(F)c(c(F)c1Cl)S(=O)(=O)Nc1cscn1)c1ccccc1
Show InChI InChI=1S/C22H22ClF2N3O3S2/c1-14(15-5-3-2-4-6-15)28-9-7-16(8-10-28)31-18-11-17(24)22(21(25)20(18)23)33(29,30)27-19-12-32-13-26-19/h2-6,11-14,16,27H,7-10H2,1H3/t14-/m1/s1
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n/an/a 37n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
ep nav1.6


(Homo sapiens (Human))
BDBM373821
PNG
((R)-5-chloro-2-fluoro-4-(1-(3-methylbenzyl)pyrroli...)
Show SMILES Cc1cccc(CN2CC[C@H](C2)Nc2cc(F)c(cc2Cl)S(=O)(=O)Nc2nccs2)c1
Show InChI InChI=1S/C21H22ClFN4O2S2/c1-14-3-2-4-15(9-14)12-27-7-5-16(13-27)25-19-11-18(23)20(10-17(19)22)31(28,29)26-21-24-6-8-30-21/h2-4,6,8-11,16,25H,5,7,12-13H2,1H3,(H,24,26)/t16-/m1/s1
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n/an/a 39n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM373767
PNG
((S)-3-chloro-4-((1-(2-fluoro-3-methylbenzyl)pyrrol...)
Show SMILES CN([C@H]1CCN(Cc2cccc(C)c2F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H23ClFN5O2S2/c1-14-4-3-5-15(20(14)23)11-28-9-8-16(12-28)27(2)19-7-6-17(10-18(19)22)32(29,30)26-21-24-13-25-31-21/h3-7,10,13,16H,8-9,11-12H2,1-2H3,(H,24,25,26)/t16-/m0/s1
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n/an/a 39n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM373766
PNG
((S)-3-chloro-4-((1-(5-chloro-2-fluorobenzyl)pyrrol...)
Show SMILES CN([C@H]1CCN(Cc2cc(Cl)ccc2F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H20Cl2FN5O2S2/c1-27(15-6-7-28(11-15)10-13-8-14(21)2-4-18(13)23)19-5-3-16(9-17(19)22)32(29,30)26-20-24-12-25-31-20/h2-5,8-9,12,15H,6-7,10-11H2,1H3,(H,24,25,26)/t15-/m0/s1
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n/an/a 41n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
ep nav1.6


(Homo sapiens (Human))
BDBM374031
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cccc(F)n1
Show InChI InChI=1S/C24H25F3N4O2S/c1-16-20(30(2)18-11-12-31(15-18)14-17-7-4-3-5-8-17)13-19(25)24(23(16)27)34(32,33)29-22-10-6-9-21(26)28-22/h3-10,13,18H,11-12,14-15H2,1-2H3,(H,28,29)/t18-/m0/s1
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n/an/a 43n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM373968
PNG
((S)-2,6-difluoro-4-((1-(3-fluorobenzyl)pyrrolidin-...)
Show SMILES CN([C@H]1CCN(Cc2cccc(F)c2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H23F3N4O2S2/c1-14-19(9-18(24)22(21(14)25)33(30,31)27-20-12-32-13-26-20)28(2)17-6-7-29(11-17)10-15-4-3-5-16(23)8-15/h3-5,8-9,12-13,17,27H,6-7,10-11H2,1-2H3/t17-/m0/s1
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n/an/a 47n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM373765
PNG
((S)-3-chloro-4-((1-(3-chloro-2-fluorobenzyl)pyrrol...)
Show SMILES CN([C@H]1CCN(Cc2cccc(Cl)c2F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H20Cl2FN5O2S2/c1-27(14-7-8-28(11-14)10-13-3-2-4-16(21)19(13)23)18-6-5-15(9-17(18)22)32(29,30)26-20-24-12-25-31-20/h2-6,9,12,14H,7-8,10-11H2,1H3,(H,24,25,26)/t14-/m0/s1
PDB

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n/an/a 47n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM373840
PNG
((S)-2-fluoro-4-((1-((2-isopropylthiazol-4-yl)methy...)
Show SMILES CC(C)c1nc(CN2CC[C@@H](C2)N(C)c2cc(F)c(cc2C)S(=O)(=O)Nc2cscn2)cs1
Show InChI InChI=1S/C22H28FN5O2S3/c1-14(2)22-25-16(11-32-22)9-28-6-5-17(10-28)27(4)19-8-18(23)20(7-15(19)3)33(29,30)26-21-12-31-13-24-21/h7-8,11-14,17,26H,5-6,9-10H2,1-4H3/t17-/m0/s1
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n/an/a 49n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM373871
PNG
((S)-4-((1-((2-cyclopropylthiazol-4-yl)methyl)pyrro...)
Show SMILES CN([C@H]1CCN(Cc2csc(n2)C2CC2)C1)c1cc(F)c(cc1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H26FN5O2S3/c1-14-7-20(33(29,30)26-21-12-31-13-24-21)18(23)8-19(14)27(2)17-5-6-28(10-17)9-16-11-32-22(25-16)15-3-4-15/h7-8,11-13,15,17,26H,3-6,9-10H2,1-2H3/t17-/m0/s1
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n/an/a 50n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
ep nav1.6


(Homo sapiens (Human))
BDBM470680
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2-f...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(cc1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H25FN4O2S2/c1-16-10-21(31(28,29)25-22-14-30-15-24-22)19(23)11-20(16)26(2)18-8-9-27(13-18)12-17-6-4-3-5-7-17/h3-7,10-11,14-15,18,25H,8-9,12-13H2,1-2H3/t18-/m0/s1
PDB

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n/an/a 54n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
ep nav1.6


(Homo sapiens (Human))
BDBM373815
PNG
(3-chloro-4-(1-((6-methylpyridin-2-yl)methyl)piperi...)
Show SMILES Cc1cccc(CN2CCC(CC2)Oc2ccc(cc2Cl)S(=O)(=O)Nc2nccs2)n1
Show InChI InChI=1S/C21H23ClN4O3S2/c1-15-3-2-4-16(24-15)14-26-10-7-17(8-11-26)29-20-6-5-18(13-19(20)22)31(27,28)25-21-23-9-12-30-21/h2-6,9,12-13,17H,7-8,10-11,14H2,1H3,(H,23,25)
PDB

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n/an/a 56n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM373851
PNG
((S)-2-fluoro-5-methyl-4-(methyl(1-((1-(2,2,2-trifl...)
Show SMILES CN([C@H]1CCN(Cc2ccn(CC(F)(F)F)n2)C1)c1cc(F)c(cc1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C21H24F4N6O2S2/c1-14-7-19(35(32,33)28-20-11-34-13-26-20)17(22)8-18(14)29(2)16-4-5-30(10-16)9-15-3-6-31(27-15)12-21(23,24)25/h3,6-8,11,13,16,28H,4-5,9-10,12H2,1-2H3/t16-/m0/s1
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n/an/a 58n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
ep nav1.6


(Homo sapiens (Human))
BDBM373762
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-3-c...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H22ClN5O2S2/c1-25(16-9-10-26(13-16)12-15-5-3-2-4-6-15)19-8-7-17(11-18(19)21)30(27,28)24-20-22-14-23-29-20/h2-8,11,14,16H,9-10,12-13H2,1H3,(H,22,23,24)/t16-/m0/s1
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n/an/a 60n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM470682
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H24F2N4O2S2/c1-15-19(27(2)17-8-9-28(12-17)11-16-6-4-3-5-7-16)10-18(23)22(21(15)24)32(29,30)26-20-13-31-14-25-20/h3-7,10,13-14,17,26H,8-9,11-12H2,1-2H3/t17-/m0/s1
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n/an/a 61n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM444553
PNG
((S)-3-chloro-2,6-difluoro-4-(methyl (1-((6-methylp...)
Show SMILES CN([C@H]1CCN(Cc2cccc(C)n2)C1)c1cc(F)c(c(F)c1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H21ClF2N6O2S2/c1-12-4-3-5-13(26-12)9-29-7-6-14(10-29)28(2)16-8-15(22)19(18(23)17(16)21)33(30,31)27-20-24-11-25-32-20/h3-5,8,11,14H,6-7,9-10H2,1-2H3,(H,24,25,27)/t14-/m0/s1
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n/an/a 62n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM374012
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1ccsn1
Show InChI InChI=1S/C22H24F2N4O2S2/c1-15-19(27(2)17-8-10-28(14-17)13-16-6-4-3-5-7-16)12-18(23)22(21(15)24)32(29,30)26-20-9-11-31-25-20/h3-7,9,11-12,17H,8,10,13-14H2,1-2H3,(H,25,26)/t17-/m0/s1
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n/an/a 64n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM373970
PNG
((S)-4-((1-(2,3-difluorobenzyl)pyrrolidin-3-yl)(met...)
Show SMILES CN([C@H]1CCN(Cc2cccc(F)c2F)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H22F4N4O2S2/c1-13-18(8-17(24)22(20(13)25)34(31,32)28-19-11-33-12-27-19)29(2)15-6-7-30(10-15)9-14-4-3-5-16(23)21(14)26/h3-5,8,11-12,15,28H,6-7,9-10H2,1-2H3/t15-/m0/s1
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n/an/a 64n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
ep nav1.6


(Homo sapiens (Human))
BDBM374000
PNG
((S)-3-chloro-2,6-difluoro-4-(methyl(1-((6-methylpy...)
Show SMILES CN([C@H]1CCN(Cc2cccc(C)n2)C1)c1cc(F)c(c(F)c1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C21H22ClF2N5O2S2/c1-13-4-3-5-14(26-13)9-29-7-6-15(10-29)28(2)17-8-16(23)21(20(24)19(17)22)33(30,31)27-18-11-32-12-25-18/h3-5,8,11-12,15,27H,6-7,9-10H2,1-2H3/t15-/m0/s1
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n/an/a 66n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM373969
PNG
((S)-2,6-difluoro-4-((1-(2-fluorobenzyl)pyrrolidin-...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2F)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H23F3N4O2S2/c1-14-19(9-18(24)22(21(14)25)33(30,31)27-20-12-32-13-26-20)28(2)16-7-8-29(11-16)10-15-5-3-4-6-17(15)23/h3-6,9,12-13,16,27H,7-8,10-11H2,1-2H3/t16-/m0/s1
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n/an/a 67n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM374016
PNG
((R)-2,6-difluoro-3-methyl-4-((1-(1-phenylethyl)pip...)
Show SMILES C[C@@H](N1CCC(CC1)Oc1cc(F)c(c(F)c1Cl)S(=O)(=O)Nc1cscn1)c1ccccc1
Show InChI InChI=1S/C22H22ClF2N3O3S2/c1-14(15-5-3-2-4-6-15)28-9-7-16(8-10-28)31-18-11-17(24)22(21(25)20(18)23)33(29,30)27-19-12-32-13-26-19/h2-6,11-14,16,27H,7-10H2,1H3/t14-/m1/s1
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n/an/a 67n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
ep nav1.6


(Homo sapiens (Human))
BDBM373760
PNG
((S)-3-chloro-4-((1-(3-chlorobenzyl)pyrrolidin-3-yl...)
Show SMILES CN([C@H]1CCN(Cc2cccc(Cl)c2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C21H22Cl2N4O2S2/c1-26(17-7-9-27(14-17)13-15-3-2-4-16(22)11-15)20-6-5-18(12-19(20)23)31(28,29)25-21-24-8-10-30-21/h2-6,8,10-12,17H,7,9,13-14H2,1H3,(H,24,25)/t17-/m0/s1
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n/an/a 70n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10815229 (2020)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%