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Patent code US10815244

Compile Data Set for Download or QSAR
Found 10 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM470588
PNG
(US10815244, Example U)
Show SMILES O[C@H]1CO[C@@H]2[C@H](CO[C@H]12)Oc1ccc(Nc2ncnc3ccsc23)cc1Cl
Show InChI InChI=1S/C18H16ClN3O4S/c19-10-5-9(22-18-17-11(3-4-27-17)20-8-21-18)1-2-13(10)26-14-7-25-15-12(23)6-24-16(14)15/h1-5,8,12,14-16,23H,6-7H2,(H,20,21,22)/t12-,14-,15+,16+/m0/s1
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n/an/a>100n/an/an/an/an/an/a



RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

US Patent


Assay Description
Briefly, the assay method measures ADP formed from EGFR kinase activity using luminescence derived from ATP-Luciferase detection system. Purified EGF...


US Patent US10815244 (2020)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM470587
PNG
(US10815244, Example T)
Show SMILES COc1cc2ncnc(Nc3ccc(O[C@H]4CO[C@@H]5[C@@H](O)CO[C@H]45)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C22H22ClN3O6/c1-28-17-6-12-14(7-18(17)29-2)24-10-25-22(12)26-11-3-4-16(13(23)5-11)32-19-9-31-20-15(27)8-30-21(19)20/h3-7,10,15,19-21,27H,8-9H2,1-2H3,(H,24,25,26)/t15-,19-,20+,21+/m0/s1
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n/an/a>100n/an/an/an/an/an/a



RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

US Patent


Assay Description
Briefly, the assay method measures ADP formed from EGFR kinase activity using luminescence derived from ATP-Luciferase detection system. Purified EGF...


US Patent US10815244 (2020)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM470591
PNG
(US10815244, Example Z)
Show SMILES COc1cc2ncnc(Nc3ccc(O[C@H]4CO[C@@H]5[C@H](CO[C@H]45)OCc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C29H29N3O6/c1-33-23-12-21-22(13-24(23)34-2)30-17-31-29(21)32-19-8-10-20(11-9-19)38-26-16-37-27-25(15-36-28(26)27)35-14-18-6-4-3-5-7-18/h3-13,17,25-28H,14-16H2,1-2H3,(H,30,31,32)/t25-,26-,27+,28+/m0/s1
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n/an/a>100n/an/an/an/an/an/a



RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

US Patent


Assay Description
Briefly, the assay method measures ADP formed from EGFR kinase activity using luminescence derived from ATP-Luciferase detection system. Purified EGF...


US Patent US10815244 (2020)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM470595
PNG
(US10815244, Example DD)
Show SMILES COc1cc2ncnc(Nc3ccc(O[C@H]4CO[C@@H]5[C@H](CO[C@H]45)OC(=O)c4ccccc4)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C29H26ClN3O7/c1-35-22-11-18-20(12-23(22)36-2)31-15-32-28(18)33-17-8-9-21(19(30)10-17)39-24-13-37-27-25(14-38-26(24)27)40-29(34)16-6-4-3-5-7-16/h3-12,15,24-27H,13-14H2,1-2H3,(H,31,32,33)/t24-,25-,26+,27+/m0/s1
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n/an/a>100n/an/an/an/an/an/a



RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

US Patent


Assay Description
Briefly, the assay method measures ADP formed from EGFR kinase activity using luminescence derived from ATP-Luciferase detection system. Purified EGF...


US Patent US10815244 (2020)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM470592
PNG
(US10815244, Example AA)
Show SMILES COc1cc2ncnc(Nc3ccc(O[C@H]4CO[C@@H]5[C@H](CO[C@H]45)OCc4ccccc4)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C29H28ClN3O6/c1-34-23-11-19-21(12-24(23)35-2)31-16-32-29(19)33-18-8-9-22(20(30)10-18)39-26-15-38-27-25(14-37-28(26)27)36-13-17-6-4-3-5-7-17/h3-12,16,25-28H,13-15H2,1-2H3,(H,31,32,33)/t25-,26-,27+,28+/m0/s1
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n/an/a>100n/an/an/an/an/an/a



RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

US Patent


Assay Description
Briefly, the assay method measures ADP formed from EGFR kinase activity using luminescence derived from ATP-Luciferase detection system. Purified EGF...


US Patent US10815244 (2020)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM470593
PNG
(US10815244, Example BB)
Show SMILES COc1cc2ncnc(Nc3ccc(O[C@H]4CO[C@@H]5[C@H](CO[C@H]45)OC(C)=O)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C24H24ClN3O7/c1-12(29)34-20-9-32-23-21(10-33-22(20)23)35-17-5-4-13(6-15(17)25)28-24-14-7-18(30-2)19(31-3)8-16(14)26-11-27-24/h4-8,11,20-23H,9-10H2,1-3H3,(H,26,27,28)/t20-,21-,22+,23+/m0/s1
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n/an/a>500n/an/an/an/an/an/a



RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

US Patent


Assay Description
Briefly, the assay method measures ADP formed from EGFR kinase activity using luminescence derived from ATP-Luciferase detection system. Purified EGF...


US Patent US10815244 (2020)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM470594
PNG
(US10815244, Example CC)
Show SMILES CC(=O)O[C@H]1CO[C@@H]2[C@H](CO[C@H]12)Oc1ccc(Nc2ncnc3ccsc23)cc1Cl
Show InChI InChI=1S/C20H18ClN3O5S/c1-10(25)28-15-7-26-18-16(8-27-17(15)18)29-14-3-2-11(6-12(14)21)24-20-19-13(4-5-30-19)22-9-23-20/h2-6,9,15-18H,7-8H2,1H3,(H,22,23,24)/t15-,16-,17+,18+/m0/s1
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n/an/a>500n/an/an/an/an/an/a



RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

US Patent


Assay Description
Briefly, the assay method measures ADP formed from EGFR kinase activity using luminescence derived from ATP-Luciferase detection system. Purified EGF...


US Patent US10815244 (2020)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM470589
PNG
(US10815244, Example X)
Show SMILES COc1cc2ncnc(Nc3ccc(O[C@H]4CO[C@@H]5[C@H](CO[C@H]45)OC(C)=O)cc3)c2cc1OC
Show InChI InChI=1S/C24H25N3O7/c1-13(28)33-20-10-31-23-21(11-32-22(20)23)34-15-6-4-14(5-7-15)27-24-16-8-18(29-2)19(30-3)9-17(16)25-12-26-24/h4-9,12,20-23H,10-11H2,1-3H3,(H,25,26,27)/t20-,21-,22+,23+/m0/s1
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n/an/a>500n/an/an/an/an/an/a



RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

US Patent


Assay Description
Briefly, the assay method measures ADP formed from EGFR kinase activity using luminescence derived from ATP-Luciferase detection system. Purified EGF...


US Patent US10815244 (2020)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM470596
PNG
(US10815244, Example EE)
Show SMILES Clc1cc(Nc2ncnc3ccsc23)ccc1O[C@H]1CO[C@@H]2[C@H](CO[C@H]12)OC(=O)c1ccccc1
Show InChI InChI=1S/C25H20ClN3O5S/c26-16-10-15(29-24-23-17(8-9-35-23)27-13-28-24)6-7-18(16)33-19-11-31-22-20(12-32-21(19)22)34-25(30)14-4-2-1-3-5-14/h1-10,13,19-22H,11-12H2,(H,27,28,29)/t19-,20-,21+,22+/m0/s1
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n/an/a>500n/an/an/an/an/an/a



RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

US Patent


Assay Description
Briefly, the assay method measures ADP formed from EGFR kinase activity using luminescence derived from ATP-Luciferase detection system. Purified EGF...


US Patent US10815244 (2020)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM470590
PNG
(US10815244, Example Y)
Show SMILES CC(=O)O[C@H]1CO[C@@H]2[C@H](CO[C@H]12)Oc1ccc(Nc2ncnc3ccsc23)cc1
Show InChI InChI=1S/C20H19N3O5S/c1-11(24)27-15-8-25-18-16(9-26-17(15)18)28-13-4-2-12(3-5-13)23-20-19-14(6-7-29-19)21-10-22-20/h2-7,10,15-18H,8-9H2,1H3,(H,21,22,23)/t15-,16-,17+,18+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

US Patent


Assay Description
Briefly, the assay method measures ADP formed from EGFR kinase activity using luminescence derived from ATP-Luciferase detection system. Purified EGF...


US Patent US10815244 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%