BindingDB logo
myBDB logout

Patent code US10822348

Compile Data Set for Download or QSAR

Found 937 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467351
PNG
(N-((3R,5S)-1-Acryloyl-5-hydroxypiperidin-3-yl)-5-(...)
Show SMILES Cc1cc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4C[C@@H](O)CN(C4)C(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.98n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM468112
PNG
((R)-N-(1-Acryloylpiperidin-3-yl)-5-(5-(2-fluorophe...)
Show SMILES Fc1ccccc1Oc1ccc(nc1)-n1c2ccnc3sc(C(=O)N[C@@H]4CCCN(C4)C(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.01n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467359
PNG
((R)-N-(1-Acryloylpiperidin-3-yl)-5-(2-fluoro-4-phe...)
Show SMILES Cc1nc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCCN(C4)C(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.01n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM468101
PNG
((R)-N-(1-Acryloylpiperidin-3-yl)-5-(*S)-(6-isobuto...)
Show SMILES CC(C)COc1cc(C)c(cn1)-n1c2ccnc3sc(C(=O)N[C@@H]4CCCN(C4)C(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.31n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467852
PNG
((R)-N-(1-Acryloylpiperidin-3-yl)-4-oxo-5-(5-phenox...)
Show SMILES C=CC(=O)N1CCC[C@H](C1)NC(=O)c1sc2nccc3n(-c4ccc(Oc5ccccc5)cn4)c(=O)[nH]c1c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.31n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467359
PNG
((R)-N-(1-Acryloylpiperidin-3-yl)-5-(2-fluoro-4-phe...)
Show SMILES Cc1nc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCCN(C4)C(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.31n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM468012
PNG
(N-((3R,5S)-1-Acryloyl-5-hydroxypiperidin-3-yl)-5-(...)
Show SMILES O[C@H]1C[C@H](CN(C1)C(=O)C=C)NC(=O)c1sc2nccc3n(-c4cccc(c4)-c4cccc(F)c4F)c(=O)[nH]c1c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.31n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467898
PNG
((R,E)-N-(1-(2-Cyano-3-cyclopropylacryloyl)piperidi...)
Show SMILES O=C(N[C@@H]1CCCN(C1)C(=O)C(=C\C1CC1)\C#N)c1sc2nccc3n(-c4ccnc(c4)-c4ccccc4)c(=O)[nH]c1c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.31n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM471707
PNG
(N-((3R,5S)-1-Acryloyl-5-hydroxypiperidin-3-yl)-5-(...)
Show SMILES O[C@H]1CNC[C@@H](C1)NC(=O)c1sc2nccc3n(-c4ccc(Oc5ccccc5)cc4)c(=O)[nH]c1c23
PDB

GoogleScholar
UniChem
US Patent
n/an/a 6.31n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467367
PNG
((R)-N-(1-Acryloylpiperidin-3-yl)-4-oxo-5-(4-phenox...)
Show SMILES C=CC(=O)N1CCC[C@H](C1)NC(=O)c1sc2nccc3n(-c4ccc(Oc5ccccc5)cc4)c(=O)[nH]c1c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.31n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM468011
PNG
((R)-N-(1-Acryloylpyrrolidin-3-yl)-5-(2',3'-difluor...)
Show SMILES Fc1cccc(c1F)-c1cccc(c1)-n1c2ccnc3sc(C(=O)N[C@@H]4CCN(C4)C(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.31n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467820
PNG
(N-((3R,5R)-1-Acryloyl-5-methoxypiperidin-3-yl)-5-(...)
Show SMILES CO[C@@H]1C[C@H](CN(C1)C(=O)C=C)NC(=O)c1sc2nccc3n(-c4ccc(Oc5ccccc5)cc4C)c(=O)[nH]c1c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.31n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM472459
PNG
((R)-N-(1-Acryloylpiperidin-3-yl)-5-(*S)-(6-(cyclop...)
Show SMILES Cc1cc(OC2CCCC2)ncc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCCN(C4)C(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
UniChem
US Patent
n/an/a 6.31n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM468111
PNG
((R)-N-(1-Acryloylpyrrolidin-3-yl)-5-(*S)-(6-(cyclo...)
Show SMILES Cc1cc(OC2CCCC2)ncc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCN(C4)C(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.94n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467866
PNG
((R)-N-(1-Acryloylpiperidin-3-yl)-4-oxo-5-(3-phenox...)
Show SMILES C=CC(=O)N1CCC[C@H](C1)NC(=O)c1sc2nccc3n(-c4cccc(Oc5ccccc5)c4)c(=O)[nH]c1c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.94n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467354
PNG
((R)-N-(1-Acryloylpyrrolidin-3-yl)-5-(*S)-(2-methyl...)
Show SMILES Cc1cc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCN(C4)C(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.94n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM471715
PNG
((R)-N-(1-Acryloylpiperidin-3-yl)-5-(2-fluoro-4-phe...)
Show SMILES Fc1cc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCCN(C4)C(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
UniChem
US Patent
n/an/a 7.94n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM472284
PNG
(N-((3R,5R)-1-Acryloyl-5-hydroxypiperidin-3-yl)-4-o...)
Show SMILES O[C@H]1C[C@@H](CCN1C(=O)C=C)NC(=O)c1sc2nccc3n(-c4ccc(Oc5ccccc5)cc4)c(=O)[nH]c1c23
PDB

GoogleScholar
UniChem
US Patent
n/an/a 7.94n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM468083
PNG
((R)-N-(1-Acryloylpiperidin-3-yl)-5-(*S)-(4-methyl-...)
Show SMILES Cc1nc(Oc2ccccc2)ncc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCCN(C4)C(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.94n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM472480
PNG
((R)-N-(1-Acryloylpiperidin-3-yl)-5-(*S)-(6-isoprop...)
Show SMILES CC(C)Oc1cc(C)c(cn1)-n1c2ccnc3sc(CN[C@@H]4CCCN(C4)C(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
UniChem
US Patent
n/an/a 7.94n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467358
PNG
((R)-N-(1-Acryloylpiperidin-3-yl)-5-(*S)-(2-methyl-...)
Show SMILES Cc1cc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCCN(C4)C(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.94n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467357
PNG
(N-((3R,5R)-1-Acryloyl-5-methoxypiperidin-3-yl)-5-(...)
Show SMILES Cc1cc(Oc2ccccc2)ncc1-n1c2ccnc3sc(C(=O)N[C@@H]4COC[C@@H]4NC(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.94n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467839
PNG
((R)-N-(1-Acryloylpiperidin-3-yl)-5-(3'-fluoro-[1,1...)
Show SMILES Fc1cccc(c1)-c1cccc(c1)-n1c2ccnc3sc(C(=O)N[C@@H]4CCCN(C4)C(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.94n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM468000
PNG
((R)-N-(1-Acryloylpiperidin-3-yl)-5-(*S)-(4-methyl-...)
Show SMILES Cc1cc(Oc2ccccc2)ncc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCCN(C4)C(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.94n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467724
PNG
((R,E)-N-(1-(4-Aminobut-2-enoyl)pyrrolidin-3-yl)-5-...)
Show SMILES Cc1cc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCN(C4)C(=O)\C=C\CN)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.94n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467894
PNG
(5-(*S)-(2-Methyl-4-phenoxyphenyl)-4-oxo-N-((R)-1-(...)
Show SMILES Cc1cc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCN(C4)C(=O)\C=C\CN4C[C@H]5OCCO[C@H]5C4)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.94n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM468007
PNG
((R)-N-(1-Acryloylpiperidin-3-yl)-5-(*S)-(6-isobuty...)
Show SMILES CC(C)Cc1cc(C)c(cn1)-n1c2ccnc3sc(C(=O)N[C@@H]4CCCN(C4)C(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.94n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM468023
PNG
((R)-N-(1-Acryloylpiperidin-3-yl)-4-oxo-5-(6-phenyl...)
Show SMILES C=CC(=O)N1CCC[C@H](C1)NC(=O)c1sc2nccc3n(-c4cc(ncn4)-c4ccccc4)c(=O)[nH]c1c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.94n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM468010
PNG
((R)-N-(1-Acryloylpiperidin-3-yl)-5-(6-cyclobutoxy-...)
Show SMILES Cc1cc(OC2CCC2)ncc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCCN(C4)C(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.94n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467396
PNG
((R,E)-N-(1-(2-Cyano-3-cyclopropylacryloyl)piperidi...)
Show SMILES O=C(N[C@@H]1CCCN(C1)C(=O)C(=C\C1CC1)\C#N)c1sc2nccc3n(-c4ccc(Oc5ccccc5)cc4)c(=O)[nH]c1c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467823
PNG
(N-((3R,5S)-1-Acryloyl-5-fluoropiperidin-3-yl)-5-(*...)
Show SMILES Cc1cc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4C[C@H](F)CN(C4)C(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM468114
PNG
((R)-N-(1-Acryloylpyrrolidin-3-yl)-5-(*S)-(6-isobut...)
Show SMILES CC(C)COc1cc(C)c(cn1)-n1c2ccnc3sc(C(=O)N[C@@H]4CCN(C4)C(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467849
PNG
((R)-N-(1-Acryloylpiperidin-3-yl)-5-(2'-chloro-[1,1...)
Show SMILES Clc1ccccc1-c1cccc(c1)-n1c2ccnc3sc(C(=O)N[C@@H]4CCCN(C4)C(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467737
PNG
((R)-N-(1-(2-Chloroacetyl)pyrrolidin-3-yl)-5-(2-met...)
Show SMILES Cc1cc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCN(C4)C(=O)CCl)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467452
PNG
((R)-5-(2-Methyl-4-phenoxyphenyl)-N-(1-(3- (methyls...)
Show SMILES Cc1cc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCN(C4)C(=O)CCS(C)(=O)=O)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM468004
PNG
((R)-N-(1-Acryloylpyrrolidin-3-yl)-5-(*R)-(2-methyl...)
Show SMILES Cc1nc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCN(C4)C(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467379
PNG
((R,E)-N-(1-(4-Hydroxybut-2-enoyl)pyrrolidin-3-yl)-...)
Show SMILES Cc1cc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCN(C4)C(=O)\C=C\CO)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467714
PNG
((R)-5-(2-Methyl-4-phenoxyphenyl)-4-oxo-N-(1- (viny...)
Show SMILES Cc1cc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCCN(C4)S(=O)(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM468113
PNG
((R)-N-(1-Acryloylpiperidin-3-yl)-5-(2-methyl-4-(py...)
Show SMILES Cc1cc(Oc2ccccn2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCCN(C4)C(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM468160
PNG
((R,E)-N-(1-(2-Cyano-3-cyclopropylacryloyl)piperidi...)
Show SMILES Cc1cc(ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCCN(C4)C(=O)C(=C\C4CC4)\C#N)c([nH]c1=O)c23)C(=O)Nc1cc(ccn1)C(F)(F)F
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467843
PNG
((R)-N-(1-Acryloylpiperidin-3-yl)-5-(2'-methyl-[1,1...)
Show SMILES Cc1ccccc1-c1cccc(c1)-n1c2ccnc3sc(C(=O)N[C@@H]4CCCN(C4)C(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467994
PNG
(N-((3R,4R)-1-Acryloyl-4-hydroxypiperidin-3-yl)-4-o...)
Show SMILES O[C@@H]1CCN(C[C@H]1NC(=O)c1sc2nccc3n(-c4ccc(Oc5ccccc5)cc4)c(=O)[nH]c1c23)C(=O)C=C
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM468001
PNG
((R)-N-(1-Acryloylpyrrolidin-3-yl)-5-(*S)-(4-methyl...)
Show SMILES Cc1cc(Oc2ccccc2)ncc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCN(C4)C(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM468030
PNG
((R)-N-(1-Acryloylpiperidin-3-yl)-5-(2-cyclopentylp...)
Show SMILES C=CC(=O)N1CCC[C@H](C1)NC(=O)c1sc2nccc3n(-c4ccnc(c4)C4CCCC4)c(=O)[nH]c1c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467711
PNG
((R)-5-(2-Methyl-4-phenoxyphenyl)-4-oxo-N-(1- (viny...)
Show SMILES Cc1cc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCN(C4)S(=O)(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467363
PNG
(N-((3R,5S)-1-Acryloyl-5-methoxypiperidin-3-yl)-5-(...)
Show SMILES CO[C@H]1C[C@H](CN(C1)C(=O)C=C)NC(=O)c1sc2nccc3n(-c4ccc(Oc5ccccc5)cc4C)c(=O)[nH]c1c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467719
PNG
((R,E)-5-(2-Methyl-4-phenoxyphenyl)-N-(1-(4-(methyl...)
Show SMILES CNC\C=C\C(=O)N1CC[C@H](C1)NC(=O)c1sc2nccc3n(-c4ccc(Oc5ccccc5)cc4C)c(=O)[nH]c1c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467370
PNG
((R,E)-N-(1-(2-cyano-3-(3-methyloxetan-3-yl)acryloy...)
Show SMILES Cc1cc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCCN(C4)C(=O)C(=C\C4(C)COC4)\C#N)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 12.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467710
PNG
((R,E)-N-(1-(4-(Dimethylamino)but-2-enoyl)pyrrolidi...)
Show SMILES CN(C)C\C=C\C(=O)N1CC[C@H](C1)NC(=O)c1sc2nccc3n(-c4ccc(Oc5ccccc5)cc4C)c(=O)[nH]c1c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 12.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK (386-659)


(Homo sapiens (Human))
BDBM467386
PNG
(N-((3S,4R)-1-Acryloyl-4-fluoropyrrolidin-3-yl)-5-(...)
Show SMILES Cc1cc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)N[C@H]4CN(C[C@H]4F)C(=O)C=C)c([nH]c1=O)c23
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 12.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10822348 (2020)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 937 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%