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Patent code US10828290

Compile Data Set for Download or QSAR

Found 327 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM377145
PNG
(N-{4-[(3S)-3-Aminopiperidin-1-yl]quinolin-3-yl}-2-...)
Show SMILES N[C@H]1CCCN(C1)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnc2ccccc12
Show InChI InChI=1S/C24H21F2N5OS/c25-16-7-3-8-17(26)21(16)24-30-20(13-33-24)23(32)29-19-11-28-18-9-2-1-6-15(18)22(19)31-10-4-5-14(27)12-31/h1-3,6-9,11,13-14H,4-5,10,12,27H2,(H,29,32)/t14-/m0/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM377145
PNG
(N-{4-[(3S)-3-Aminopiperidin-1-yl]quinolin-3-yl}-2-...)
Show SMILES N[C@H]1CCCN(C1)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnc2ccccc12
Show InChI InChI=1S/C24H21F2N5OS/c25-16-7-3-8-17(26)21(16)24-30-20(13-33-24)23(32)29-19-11-28-18-9-2-1-6-15(18)22(19)31-10-4-5-14(27)12-31/h1-3,6-9,11,13-14H,4-5,10,12,27H2,(H,29,32)/t14-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM377185
PNG
(N-{4-[(3S)-3-aminopiperidin-1-yl]-1H-pyrazolo[3,4-...)
Show SMILES N[C@H]1CCCN(C1)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnc2[nH]ncc12
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM377226
PNG
(N-{4-[(3S)-3-Aminopiperidin-1-yl]-7-hydroxy-6,7-di...)
Show SMILES CS(=O)(=O)c1cc(F)c(c(F)c1)-c1nc(ccc1F)C(=O)Nc1cnc2[C@@H](O)CCc2c1N1CCC[C@H](N)C1
Show InChI InChI=1S/C26H26F3N5O4S/c1-39(37,38)14-9-17(28)22(18(29)10-14)24-16(27)5-6-19(32-24)26(36)33-20-11-31-23-15(4-7-21(23)35)25(20)34-8-2-3-13(30)12-34/h5-6,9-11,13,21,35H,2-4,7-8,12,30H2,1H3,(H,33,36)/t13-,21-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM377185
PNG
(N-{4-[(3S)-3-aminopiperidin-1-yl]-1H-pyrazolo[3,4-...)
Show SMILES N[C@H]1CCCN(C1)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnc2[nH]ncc12
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM377174
PNG
(5-Amino-N-{4-[3,4-trans-3-amino-4-hydroxypiperidin...)
Show SMILES N[C@@H]1CN(CC[C@H]1O)c1c2CCCc2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C23H24F2N6O2S/c24-12-4-2-5-13(25)18(12)23-30-19(21(27)34-23)22(33)29-16-9-28-15-6-1-3-11(15)20(16)31-8-7-17(32)14(26)10-31/h2,4-5,9,14,17,32H,1,3,6-8,10,26-27H2,(H,29,33)/t14-,17-/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM377178
PNG
(5-Amino-N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methy...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1c2CCCc2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C24H26F2N6O2S/c1-11-9-32(10-15(27)21(11)33)20-12-4-2-7-16(12)29-8-17(20)30-23(34)19-22(28)35-24(31-19)18-13(25)5-3-6-14(18)26/h3,5-6,8,11,15,21,33H,2,4,7,9-10,27-28H2,1H3,(H,30,34)/t11-,15+,21+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM377179
PNG
(5-Amino-N-{7-[3,4-trans-3-amino-4-hydroxypiperidin...)
Show SMILES N[C@@H]1CN(CC[C@H]1O)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnc2ccsc12
Show InChI InChI=1S/C22H20F2N6O2S2/c23-10-2-1-3-11(24)16(10)22-29-17(20(26)34-22)21(32)28-14-8-27-13-5-7-33-19(13)18(14)30-6-4-15(31)12(25)9-30/h1-3,5,7-8,12,15,31H,4,6,9,25-26H2,(H,28,32)/t12-,15-/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM377181
PNG
(5-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-5,6,7,8-...)
Show SMILES N[C@H]1CCCN(C1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnc2NCCCc12
Show InChI InChI=1S/C23H25F2N7OS/c24-14-6-1-7-15(25)17(14)23-31-18(20(27)34-23)22(33)30-16-10-29-21-13(5-2-8-28-21)19(16)32-9-3-4-12(26)11-32/h1,6-7,10,12H,2-5,8-9,11,26-27H2,(H,28,29)(H,30,33)/t12-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM377181
PNG
(5-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-5,6,7,8-...)
Show SMILES N[C@H]1CCCN(C1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnc2NCCCc12
Show InChI InChI=1S/C23H25F2N7OS/c24-14-6-1-7-15(25)17(14)23-31-18(20(27)34-23)22(33)30-16-10-29-21-13(5-2-8-28-21)19(16)32-9-3-4-12(26)11-32/h1,6-7,10,12H,2-5,8-9,11,26-27H2,(H,28,29)(H,30,33)/t12-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM377183
PNG
(N-{4-[(3S)-3-Aminopiperidin-1-yl]-5,6,7,8-tetrahyd...)
Show SMILES N[C@H]1CCCN(C1)c1c(NC(=O)c2ccc(F)c(n2)-c2c(F)cccc2F)cnc2NCCCc12
Show InChI InChI=1S/C25H25F3N6O/c26-16-6-1-7-17(27)21(16)22-18(28)8-9-19(32-22)25(35)33-20-12-31-24-15(5-2-10-30-24)23(20)34-11-3-4-14(29)13-34/h1,6-9,12,14H,2-5,10-11,13,29H2,(H,30,31)(H,33,35)/t14-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM377184
PNG
(5-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-1H-pyraz...)
Show SMILES N[C@H]1CCCN(C1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnc2[nH]ncc12
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM424958
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1c2CCC(O)c2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C26H26F3N5O3/c1-12-10-34(11-17(30)25(12)36)24-13-5-8-20(35)22(13)31-9-19(24)33-26(37)18-7-6-16(29)23(32-18)21-14(27)3-2-4-15(21)28/h2-4,6-7,9,12,17,20,25,35-36H,5,8,10-11,30H2,1H3,(H,33,37)/t12-,17+,20?,25+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM377189
PNG
(3-Amino-N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1c2CCOc2ncc1NC(=O)c1nc(c(F)cc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C25H25F3N6O2/c1-12-7-13(29)11-34(10-12)23-14-5-6-36-25(14)31-9-19(23)32-24(35)22-18(30)8-17(28)21(33-22)20-15(26)3-2-4-16(20)27/h2-4,8-9,12-13H,5-7,10-11,29-30H2,1H3,(H,32,35)/t12-,13+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM377191
PNG
(5-Amino-N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methy...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1c2CCOc2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C23H24F2N6O3S/c1-10-8-31(9-14(26)19(10)32)18-11-5-6-34-22(11)28-7-15(18)29-21(33)17-20(27)35-23(30-17)16-12(24)3-2-4-13(16)25/h2-4,7,10,14,19,32H,5-6,8-9,26-27H2,1H3,(H,29,33)/t10-,14+,19+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM471777
PNG
(US10828290, Example 46 (Diastereoisomer 2))
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1c2CC[C@@H](O)c2ncc1NC(=O)c1nc(ccc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C26H28F2N6O2/c1-13-9-14(29)12-34(11-13)25-15-5-8-21(35)23(15)31-10-20(25)33-26(36)24-18(30)6-7-19(32-24)22-16(27)3-2-4-17(22)28/h2-4,6-7,10,13-14,21,35H,5,8-9,11-12,29-30H2,1H3,(H,33,36)/t13-,14+,21-/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM377201
PNG
(5-Amino-N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1c2CC[C@H](O)c2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C24H26F2N6O2S/c1-11-7-12(27)10-32(9-11)21-13-5-6-17(33)19(13)29-8-16(21)30-23(34)20-22(28)35-24(31-20)18-14(25)3-2-4-15(18)26/h2-4,8,11-12,17,33H,5-7,9-10,27-28H2,1H3,(H,30,34)/t11-,12+,17+/m1/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM377208
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES CCOc1cc(F)c(c(F)c1)-c1nc(ccc1F)C(=O)Nc1cnc2[C@@H](O)CCc2c1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C28H30F3N5O4/c1-3-40-14-8-17(30)23(18(31)9-14)25-16(29)5-6-20(34-25)28(39)35-21-10-33-24-15(4-7-22(24)37)26(21)36-11-13(2)27(38)19(32)12-36/h5-6,8-10,13,19,22,27,37-38H,3-4,7,11-12,32H2,1-2H3,(H,35,39)/t13-,19+,22-,27+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM377209
PNG
(US10265307, Example 51-2 | US10517858, Example 51 ...)
Show SMILES CCOc1cc(F)c(c(F)c1)-c1nc(ccc1F)C(=O)Nc1cnc2[C@H](O)CCc2c1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C28H30F3N5O4/c1-3-40-14-8-17(30)23(18(31)9-14)25-16(29)5-6-20(34-25)28(39)35-21-10-33-24-15(4-7-22(24)37)26(21)36-11-13(2)27(38)19(32)12-36/h5-6,8-10,13,19,22,27,37-38H,3-4,7,11-12,32H2,1-2H3,(H,35,39)/t13-,19+,22+,27+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM377210
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1c2CCCc2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C26H26F3N5O2/c1-13-11-34(12-18(30)25(13)35)24-14-4-2-7-19(14)31-10-21(24)33-26(36)20-9-8-17(29)23(32-20)22-15(27)5-3-6-16(22)28/h3,5-6,8-10,13,18,25,35H,2,4,7,11-12,30H2,1H3,(H,33,36)/t13-,18+,25+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM377212
PNG
(US10265307, Example 53-2 | US10517858, Example 53 ...)
Show SMILES COc1ccc(F)c(-c2nc(C(=O)Nc3cnc4[C@H](O)CCc4c3N3CCC[C@H](N)C3)c(N)s2)c1F
Show InChI InChI=1S/C24H26F2N6O3S/c1-35-16-7-5-13(25)17(18(16)26)24-31-20(22(28)36-24)23(34)30-14-9-29-19-12(4-6-15(19)33)21(14)32-8-2-3-11(27)10-32/h5,7,9,11,15,33H,2-4,6,8,10,27-28H2,1H3,(H,30,34)/t11-,15+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM377216
PNG
(US10265307, Example 55-2 | US10517858, Example 55 ...)
Show SMILES COc1ccc(F)c(c1F)-c1nc(ccc1F)C(=O)Nc1cnc2[C@H](O)CCc2c1N1CCC[C@H](N)C1
Show InChI InChI=1S/C26H26F3N5O3/c1-37-20-9-6-15(27)21(22(20)29)24-16(28)5-7-17(32-24)26(36)33-18-11-31-23-14(4-8-19(23)35)25(18)34-10-2-3-13(30)12-34/h5-7,9,11,13,19,35H,2-4,8,10,12,30H2,1H3,(H,33,36)/t13-,19+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM377217
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-7-hy...)
Show SMILES COc1ccc(F)c(c1F)-c1nc(ccc1F)C(=O)Nc1cnc2[C@@H](O)CCc2c1N1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C27H28F3N5O3/c1-13-9-14(31)12-35(11-13)26-15-3-7-20(36)24(15)32-10-19(26)34-27(37)18-6-4-17(29)25(33-18)22-16(28)5-8-21(38-2)23(22)30/h4-6,8,10,13-14,20,36H,3,7,9,11-12,31H2,1-2H3,(H,34,37)/t13-,14+,20+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM377218
PNG
(US10265307, Example 56-2 | US10517858, Example 56 ...)
Show SMILES COc1ccc(F)c(c1F)-c1nc(ccc1F)C(=O)Nc1cnc2[C@H](O)CCc2c1N1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C27H28F3N5O3/c1-13-9-14(31)12-35(11-13)26-15-3-7-20(36)24(15)32-10-19(26)34-27(37)18-6-4-17(29)25(33-18)22-16(28)5-8-21(38-2)23(22)30/h4-6,8,10,13-14,20,36H,3,7,9,11-12,31H2,1-2H3,(H,34,37)/t13-,14+,20-/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM377223
PNG
(US10265307, Example 59-2 | US10517858, Example 59 ...)
Show SMILES CS(=O)c1cc(F)c(c(F)c1)-c1nc(ccc1F)C(=O)Nc1cnc2[C@H](O)CCc2c1N1CCC[C@H](N)C1
Show InChI InChI=1S/C26H26F3N5O3S/c1-38(37)14-9-17(28)22(18(29)10-14)24-16(27)5-6-19(32-24)26(36)33-20-11-31-23-15(4-7-21(23)35)25(20)34-8-2-3-13(30)12-34/h5-6,9-11,13,21,35H,2-4,7-8,12,30H2,1H3,(H,33,36)/t13-,21+,38?/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM377224
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-7-hy...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1c2CC[C@H](O)c2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(cc1F)S(C)=O
Show InChI InChI=1S/C27H28F3N5O3S/c1-13-7-14(31)12-35(11-13)26-16-3-6-22(36)24(16)32-10-21(26)34-27(37)20-5-4-17(28)25(33-20)23-18(29)8-15(39(2)38)9-19(23)30/h4-5,8-10,13-14,22,36H,3,6-7,11-12,31H2,1-2H3,(H,34,37)/t13-,14+,22+,39?/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM377226
PNG
(N-{4-[(3S)-3-Aminopiperidin-1-yl]-7-hydroxy-6,7-di...)
Show SMILES CS(=O)(=O)c1cc(F)c(c(F)c1)-c1nc(ccc1F)C(=O)Nc1cnc2[C@@H](O)CCc2c1N1CCC[C@H](N)C1
Show InChI InChI=1S/C26H26F3N5O4S/c1-39(37,38)14-9-17(28)22(18(29)10-14)24-16(27)5-6-19(32-24)26(36)33-20-11-31-23-15(4-7-21(23)35)25(20)34-8-2-3-13(30)12-34/h5-6,9-11,13,21,35H,2-4,7-8,12,30H2,1H3,(H,33,36)/t13-,21-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM377227
PNG
(US10265307, Example 61-2 | US10517858, Example 61 ...)
Show SMILES CS(=O)(=O)c1cc(F)c(c(F)c1)-c1nc(ccc1F)C(=O)Nc1cnc2[C@H](O)CCc2c1N1CCC[C@H](N)C1
Show InChI InChI=1S/C26H26F3N5O4S/c1-39(37,38)14-9-17(28)22(18(29)10-14)24-16(27)5-6-19(32-24)26(36)33-20-11-31-23-15(4-7-21(23)35)25(20)34-8-2-3-13(30)12-34/h5-6,9-11,13,21,35H,2-4,7-8,12,30H2,1H3,(H,33,36)/t13-,21+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM377230
PNG
(N-{4-[(3R,5S)-3-Amino-4-hydroxy-4,5-dimethylpiperi...)
Show SMILES C[C@H]1CN(C[C@@H](N)C1(C)O)c1c2CC[C@H](O)c2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C27H28F3N5O3/c1-13-11-35(12-21(31)27(13,2)38)25-14-6-9-20(36)23(14)32-10-19(25)34-26(37)18-8-7-17(30)24(33-18)22-15(28)4-3-5-16(22)29/h3-5,7-8,10,13,20-21,36,38H,6,9,11-12,31H2,1-2H3,(H,34,37)/t13-,20-,21+,27?/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM377230
PNG
(N-{4-[(3R,5S)-3-Amino-4-hydroxy-4,5-dimethylpiperi...)
Show SMILES C[C@H]1CN(C[C@@H](N)C1(C)O)c1c2CC[C@H](O)c2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C27H28F3N5O3/c1-13-11-35(12-21(31)27(13,2)38)25-14-6-9-20(36)23(14)32-10-19(25)34-26(37)18-8-7-17(30)24(33-18)22-15(28)4-3-5-16(22)29/h3-5,7-8,10,13,20-21,36,38H,6,9,11-12,31H2,1-2H3,(H,34,37)/t13-,20-,21+,27?/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM471813
PNG
(N-{4-[(3R,5S)-3-Amino-4-hydroxy-4,5-dimethylpiperi...)
Show SMILES C[C@H]1CN(C[C@@H](N)C1(C)O)c1c2CCC(O)c2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C27H28F3N5O3/c1-13-11-35(12-21(31)27(13,2)38)25-14-6-9-20(36)23(14)32-10-19(25)34-26(37)18-8-7-17(30)24(33-18)22-15(28)4-3-5-16(22)29/h3-5,7-8,10,13,20-21,36,38H,6,9,11-12,31H2,1-2H3,(H,34,37)/t13-,20?,21+,27?/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM471813
PNG
(N-{4-[(3R,5S)-3-Amino-4-hydroxy-4,5-dimethylpiperi...)
Show SMILES C[C@H]1CN(C[C@@H](N)C1(C)O)c1c2CCC(O)c2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C27H28F3N5O3/c1-13-11-35(12-21(31)27(13,2)38)25-14-6-9-20(36)23(14)32-10-19(25)34-26(37)18-8-7-17(30)24(33-18)22-15(28)4-3-5-16(22)29/h3-5,7-8,10,13,20-21,36,38H,6,9,11-12,31H2,1-2H3,(H,34,37)/t13-,20?,21+,27?/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM377234
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1c2CCOc2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(cc1F)C(C)(C)O
Show InChI InChI=1S/C28H30F3N5O4/c1-13-11-36(12-19(32)25(13)37)24-15-6-7-40-27(15)33-10-21(24)35-26(38)20-5-4-16(29)23(34-20)22-17(30)8-14(9-18(22)31)28(2,3)39/h4-5,8-10,13,19,25,37,39H,6-7,11-12,32H2,1-3H3,(H,35,38)/t13-,19+,25+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM377249
PNG
(US10265307, Example 72-2 | US10517858, Example 72 ...)
Show SMILES CC(C)(O)c1cc(F)c(c(F)c1)-c1nc(ccc1F)C(=O)Nc1cnc2[C@H](O)CCc2c1N1C[C@@H](N)C[C@H](C1)C(F)(F)F
Show InChI InChI=1S/C29H29F6N5O3/c1-28(2,43)13-8-18(31)23(19(32)9-13)25-17(30)4-5-20(38-25)27(42)39-21-10-37-24-16(3-6-22(24)41)26(21)40-11-14(29(33,34)35)7-15(36)12-40/h4-5,8-10,14-15,22,41,43H,3,6-7,11-12,36H2,1-2H3,(H,39,42)/t14-,15+,22-/m1/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM377138
PNG
(5-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]quinolin-...)
Show SMILES N[C@H]1CCCN(C1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnc2ccccc12
Show InChI InChI=1S/C24H22F2N6OS/c25-15-7-3-8-16(26)19(15)24-31-20(22(28)34-24)23(33)30-18-11-29-17-9-2-1-6-14(17)21(18)32-10-4-5-13(27)12-32/h1-3,6-9,11,13H,4-5,10,12,27-28H2,(H,30,33)/t13-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM377147
PNG
(N-{4-[(3S)-3-Aminopiperidin-1-yl]thieno[2,3-b]pyri...)
Show SMILES N[C@H]1CCCN(C1)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnc2sccc12
Show InChI InChI=1S/C22H19F2N5OS2/c23-14-4-1-5-15(24)18(14)22-28-17(11-32-22)20(30)27-16-9-26-21-13(6-8-31-21)19(16)29-7-2-3-12(25)10-29/h1,4-6,8-9,11-12H,2-3,7,10,25H2,(H,27,30)/t12-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM377158
PNG
(5-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-hydrox...)
Show SMILES N[C@H]1CCCN(C1)c1c2CC[C@H](O)c2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C23H24F2N6O2S/c24-13-4-1-5-14(25)17(13)23-30-19(21(27)34-23)22(33)29-15-9-28-18-12(6-7-16(18)32)20(15)31-8-2-3-11(26)10-31/h1,4-5,9,11,16,32H,2-3,6-8,10,26-27H2,(H,29,33)/t11-,16-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM377160
PNG
(N-{4-[(3S)-3-Aminopiperidin-1-yl]-7-hydroxy-6,7-di...)
Show SMILES N[C@H]1CCCN(C1)c1c2CC[C@H](O)c2ncc1NC(=O)c1csc(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C23H23F2N5O2S/c24-14-4-1-5-15(25)19(14)23-29-17(11-33-23)22(32)28-16-9-27-20-13(6-7-18(20)31)21(16)30-8-2-3-12(26)10-30/h1,4-5,9,11-12,18,31H,2-3,6-8,10,26H2,(H,28,32)/t12-,18-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM377175
PNG
(5-Amino-N-{4-[(3,4-cis-3-amino-4-hydroxypiperidin-...)
Show SMILES N[C@H]1CN(CC[C@H]1O)c1c2CCCc2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C23H24F2N6O2S/c24-12-4-2-5-13(25)18(12)23-30-19(21(27)34-23)22(33)29-16-9-28-15-6-1-3-11(15)20(16)31-8-7-17(32)14(26)10-31/h2,4-5,9,14,17,32H,1,3,6-8,10,26-27H2,(H,29,33)/t14-,17+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM377177
PNG
(5-Amino-N-{4-[3.4-cis-3-amino-4-hydroxypiperidin-1...)
Show SMILES N[C@@H]1CN(CC[C@@H]1O)c1c2CCCc2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C23H24F2N6O2S/c24-12-4-2-5-13(25)18(12)23-30-19(21(27)34-23)22(33)29-16-9-28-15-6-1-3-11(15)20(16)31-8-7-17(32)14(26)10-31/h2,4-5,9,14,17,32H,1,3,6-8,10,26-27H2,(H,29,33)/t14-,17+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM377180
PNG
(5-Amino-N-{7-[3.4-cis-3-amino-4-hydroxypiperidin-1...)
Show SMILES N[C@@H]1CN(CC[C@@H]1O)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnc2ccsc12
Show InChI InChI=1S/C22H20F2N6O2S2/c23-10-2-1-3-11(24)16(10)22-29-17(20(26)34-22)21(32)28-14-8-27-13-5-7-33-19(13)18(14)30-6-4-15(31)12(25)9-30/h1-3,5,7-8,12,15,31H,4,6,9,25-26H2,(H,28,32)/t12-,15+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM377182
PNG
(3-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-5,6,7,8-...)
Show SMILES N[C@H]1CCCN(C1)c1c(NC(=O)c2nc(c(F)cc2N)-c2c(F)cccc2F)cnc2NCCCc12
Show InChI InChI=1S/C25H26F3N7O/c26-15-6-1-7-16(27)20(15)21-17(28)10-18(30)22(34-21)25(36)33-19-11-32-24-14(5-2-8-31-24)23(19)35-9-3-4-13(29)12-35/h1,6-7,10-11,13H,2-5,8-9,12,29-30H2,(H,31,32)(H,33,36)/t13-/m0/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM377186
PNG
(5-Amino-N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1c2CCOc2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C23H24F2N6O2S/c1-11-7-12(26)10-31(9-11)19-13-5-6-33-22(13)28-8-16(19)29-21(32)18-20(27)34-23(30-18)17-14(24)3-2-4-15(17)25/h2-4,8,11-12H,5-7,9-10,26-27H2,1H3,(H,29,32)/t11-,12+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM424958
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1c2CCC(O)c2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C26H26F3N5O3/c1-12-10-34(11-17(30)25(12)36)24-13-5-8-20(35)22(13)31-9-19(24)33-26(37)18-7-6-16(29)23(32-18)21-14(27)3-2-4-15(21)28/h2-4,6-7,9,12,17,20,25,35-36H,5,8,10-11,30H2,1H3,(H,33,37)/t12-,17+,20?,25+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM377189
PNG
(3-Amino-N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1c2CCOc2ncc1NC(=O)c1nc(c(F)cc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C25H25F3N6O2/c1-12-7-13(29)11-34(10-12)23-14-5-6-36-25(14)31-9-19(23)32-24(35)22-18(30)8-17(28)21(33-22)20-15(26)3-2-4-16(20)27/h2-4,8-9,12-13H,5-7,10-11,29-30H2,1H3,(H,32,35)/t12-,13+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM377195
PNG
(5-Amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)p...)
Show SMILES N[C@H]1C[C@H](CN(C1)c1c2CC[C@H](O)c2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F)C(F)(F)F
Show InChI InChI=1S/C24H23F5N6O2S/c25-13-2-1-3-14(26)17(13)23-34-19(21(31)38-23)22(37)33-15-7-32-18-12(4-5-16(18)36)20(15)35-8-10(24(27,28)29)6-11(30)9-35/h1-3,7,10-11,16,36H,4-6,8-9,30-31H2,(H,33,37)/t10-,11+,16+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM377195
PNG
(5-Amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)p...)
Show SMILES N[C@H]1C[C@H](CN(C1)c1c2CC[C@H](O)c2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F)C(F)(F)F
Show InChI InChI=1S/C24H23F5N6O2S/c25-13-2-1-3-14(26)17(13)23-34-19(21(31)38-23)22(37)33-15-7-32-18-12(4-5-16(18)36)20(15)35-8-10(24(27,28)29)6-11(30)9-35/h1-3,7,10-11,16,36H,4-6,8-9,30-31H2,(H,33,37)/t10-,11+,16+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM377201
PNG
(5-Amino-N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1c2CC[C@H](O)c2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C24H26F2N6O2S/c1-11-7-12(27)10-32(9-11)21-13-5-6-17(33)19(13)29-8-16(21)30-23(34)20-22(28)35-24(31-20)18-14(25)3-2-4-15(18)26/h2-4,8,11-12,17,33H,5-7,9-10,27-28H2,1H3,(H,30,34)/t11-,12+,17+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM377216
PNG
(US10265307, Example 55-2 | US10517858, Example 55 ...)
Show SMILES COc1ccc(F)c(c1F)-c1nc(ccc1F)C(=O)Nc1cnc2[C@H](O)CCc2c1N1CCC[C@H](N)C1
Show InChI InChI=1S/C26H26F3N5O3/c1-37-20-9-6-15(27)21(22(20)29)24-16(28)5-7-17(32-24)26(36)33-18-11-31-23-14(4-8-19(23)35)25(18)34-10-2-3-13(30)12-34/h5-7,9,11,13,19,35H,2-4,8,10,12,30H2,1H3,(H,33,36)/t13-,19+/m0/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM377219
PNG
(5-Amino-N-[4-(3-amino-3-methylpiperidin-1-yl)-6,7-...)
Show SMILES CC1(N)CCCN(C1)c1c2CCCc2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C24H26F2N6OS/c1-24(28)9-4-10-32(12-24)20-13-5-2-8-16(13)29-11-17(20)30-22(33)19-21(27)34-23(31-19)18-14(25)6-3-7-15(18)26/h3,6-7,11H,2,4-5,8-10,12,27-28H2,1H3,(H,30,33)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%