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Found 698 Enz. Inhib. hit(s) with all data for entry = 9511
LigandPNGBDBM471908((5R)-5-[3-[(3S)-4- (4-chloro- 3-fluoro- 5-methoxy-...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471909((5R)-5-[3-[4-(3,4- dichloro-5- methoxy- phenyl) pi...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471911((5R)-5-[3-[4-(3- chloro-4-fluoro- 5-methoxy- pheny...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471913((5R)-5-[3-[(3S)- 4-(3-chloro- 4-fluoro- 5-methoxy-...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471914(US10829478, Compound 150)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM471764((5S)-5- cyclopropyl- 5-[(2S)-3-[4-(3- fluoro-5-met...)
Affinity DataIC50:  12.5nMAssay Description:TABLE VI: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by human ADAMTS4.For the...More data for this Ligand-Target Pair
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LigandPNGBDBM471736(5-cyclopropyl-5- [3-[4-(3,4- difluoro-5- methoxy- ...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471740((R)-5-[3-[4-(3,4- difluoro-5- methoxy- phenyl) pip...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471743(5-cyclopropyl-5- [3-[(3S)-4-(3,4- difluoro-5- meth...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471757(5-[3-[(3S)-4-(3,4- difluoro-5- methoxy-phenyl)- 3-...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471761(5-[3-[(3S)-4-(4- chloro-3-methoxy- phenyl)-3-methy...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471764((5S)-5- cyclopropyl- 5-[(2S)-3-[4-(3- fluoro-5-met...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471766((5R)-5-[(2S)-3-[4- (3-fluoro-5- methoxy- phenyl) p...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471769(5-cyclopropyl-5- [(2S)-3-[(3S)-4- (3,4-difluoro-5-...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471771(5-[3-[(3S)-4-(4- chloro-3,5- dimethoxy- phenyl)- 3...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471775(5-[3-[4-(4-chloro- 3,5-dimethoxy- phenyl) piperazi...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471788((5S)-5- cyclopropyl- 5-[3-[(3S)-4-(3,4- difluoro-5...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471789(5-[3-[4-(4-chloro- 3-fluoro-5- methoxy- phenyl) pi...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471790(5-[3-[(3S)-4-(4- chloro-3-fluoro-5- methoxy-phenyl...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471791(5-[3-[4-(4-chloro- 3,5-dimethoxy- phenyl) piperazi...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471792(5-[3-[4-(4-chloro- 3-methoxy- phenyl)-3-methyl- pi...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471793(5-[3-[(3S)-4-(3,4- difluoro-5- methoxy-phenyl)- 3-...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471794(5-[3-[4-(3,4- difluoro-5- methoxy- phenyl) piperaz...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471933(5-[3-[(3S)-4-(4- chloro-3,5- dimethoxy- phenyl)- 3...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471795(5-[3-[(3S)-4-(3,4- difluoro-5- methoxy-phenyl)- 3-...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471796(5-[3-[(3S)-4-(4- chloro-3-methoxy- phenyl)-3-methy...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471797(5-[3-[4-(3,4- dichloro-5- methoxy- phenyl) piperaz...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471798(5-[3-[(3S)-4-(3,4- difluoro-5- methoxy-phenyl)- 3-...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471799(5-[3-[4-(3-chloro- 4-fluoro-5- methoxy- phenyl) pi...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471800(5-[3-[4-(3,4- difluoro-5- methoxy- phenyl) piperaz...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471801(5-[3-[4-(3,4- difluoro-5- methoxy- phenyl) piperaz...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471827(5-[3-[(3S)-4-(3- chloro-4-fluoro-5- methoxy-phenyl...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471828((5S)-5-[(2S)-3-[4- (3,4-difluoro-5- methoxy- pheny...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471829((5R)-5-[3-[(3S)-4- (4-chloro-3- methoxy-phenyl)- 3...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471830((5R)-5-[(2R)-3-[4- (3,4-difluoro-5- methoxy- pheny...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471831((5R)-5-[(2S)-3- [4-(3,4-difluoro- 5-methoxy- pheny...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471834((5S)-5-[(2S)-3-[4- (3,4-difluoro-5- methoxy- pheny...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471837(5-[3-[(3S)-4-(3,4- difluoro-5- methoxy-phenyl)- 3-...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471838((5S)-5-[3-[(3S)-4- (3-chloro- 4-fluoro- 5-methoxy-...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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LigandPNGBDBM471839((5R)-5-[3-[(3S)-4- (3-chloro- 4-fluoro- 5-methoxy-...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
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TargetADAMTS5(Rattus norvegicus (Rat))
Galapagos

US Patent
LigandPNGBDBM471743(5-cyclopropyl-5- [3-[(3S)-4-(3,4- difluoro-5- meth...)
Affinity DataIC50:  12.5nMAssay Description:TABLE VII: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by rnADAMTS-5 (1-564-6H...More data for this Ligand-Target Pair
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TargetADAMTS5(Rattus norvegicus (Rat))
Galapagos

US Patent
LigandPNGBDBM471764((5S)-5- cyclopropyl- 5-[(2S)-3-[4-(3- fluoro-5-met...)
Affinity DataIC50:  12.5nMAssay Description:TABLE VII: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by rnADAMTS-5 (1-564-6H...More data for this Ligand-Target Pair
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TargetADAMTS5(Rattus norvegicus (Rat))
Galapagos

US Patent
LigandPNGBDBM471788((5S)-5- cyclopropyl- 5-[3-[(3S)-4-(3,4- difluoro-5...)
Affinity DataIC50:  12.5nMAssay Description:TABLE VII: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by rnADAMTS-5 (1-564-6H...More data for this Ligand-Target Pair
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TargetADAMTS5(Rattus norvegicus (Rat))
Galapagos

US Patent
LigandPNGBDBM471792(5-[3-[4-(4-chloro- 3-methoxy- phenyl)-3-methyl- pi...)
Affinity DataIC50:  12.5nMAssay Description:TABLE VII: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by rnADAMTS-5 (1-564-6H...More data for this Ligand-Target Pair
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TargetADAMTS5(Rattus norvegicus (Rat))
Galapagos

US Patent
LigandPNGBDBM471793(5-[3-[(3S)-4-(3,4- difluoro-5- methoxy-phenyl)- 3-...)
Affinity DataIC50:  12.5nMAssay Description:TABLE VII: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by rnADAMTS-5 (1-564-6H...More data for this Ligand-Target Pair
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TargetADAMTS5(Rattus norvegicus (Rat))
Galapagos

US Patent
LigandPNGBDBM471794(5-[3-[4-(3,4- difluoro-5- methoxy- phenyl) piperaz...)
Affinity DataIC50:  12.5nMAssay Description:TABLE VII: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by rnADAMTS-5 (1-564-6H...More data for this Ligand-Target Pair
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TargetADAMTS5(Rattus norvegicus (Rat))
Galapagos

US Patent
LigandPNGBDBM471828((5S)-5-[(2S)-3-[4- (3,4-difluoro-5- methoxy- pheny...)
Affinity DataIC50:  12.5nMAssay Description:TABLE VII: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by rnADAMTS-5 (1-564-6H...More data for this Ligand-Target Pair
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TargetADAMTS5(Rattus norvegicus (Rat))
Galapagos

US Patent
LigandPNGBDBM471834((5S)-5-[(2S)-3-[4- (3,4-difluoro-5- methoxy- pheny...)
Affinity DataIC50:  12.5nMAssay Description:TABLE VII: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by rnADAMTS-5 (1-564-6H...More data for this Ligand-Target Pair
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TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM471743(5-cyclopropyl-5- [3-[(3S)-4-(3,4- difluoro-5- meth...)
Affinity DataIC50:  12.5nMAssay Description:TABLE IX: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by human ADAMTS-5.For th...More data for this Ligand-Target Pair
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TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM471764((5S)-5- cyclopropyl- 5-[(2S)-3-[4-(3- fluoro-5-met...)
Affinity DataIC50:  12.5nMAssay Description:TABLE IX: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by human ADAMTS-5.For th...More data for this Ligand-Target Pair
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