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Patent code US10829483

Compile Data Set for Download or QSAR
Found 103 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472426
PNG
(US10829483, Compound WX031)
Show SMILES C[C@@H](Sc1nnc(Br)n1-c1sc(C2CC2)c2CCCCc12)C(O)=O
Show InChI InChI=1S/C16H18BrN3O2S2/c1-8(14(21)22)23-16-19-18-15(17)20(16)13-11-5-3-2-4-10(11)12(24-13)9-6-7-9/h8-9H,2-7H2,1H3,(H,21,22)/t8-/m1/s1
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472508
PNG
(US10829483, Compound WX092)
Show SMILES Cc1cc(sc1C1CC1)-n1c(Br)nnc1SC1(CCCC1)C(O)=O
Show InChI InChI=1S/C16H18BrN3O2S2/c1-9-8-11(23-12(9)10-4-5-10)20-14(17)18-19-15(20)24-16(13(21)22)6-2-3-7-16/h8,10H,2-7H2,1H3,(H,21,22)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472467
PNG
(US10829483, Compound WX059)
Show SMILES OC(=O)C1(CCC1)Sc1nnc(Br)n1-c1sc(C2CC2)c2CCCc12
Show InChI InChI=1S/C17H18BrN3O2S2/c18-15-19-20-16(25-17(14(22)23)7-2-8-17)21(15)13-11-4-1-3-10(11)12(24-13)9-5-6-9/h9H,1-8H2,(H,22,23)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472474
PNG
(US10829483, Compound WX065)
Show SMILES CC(C)(Sc1nnc(Br)n1-c1sc(C2CC2)c2CC(C)(C)Cc12)C(O)=O
Show InChI InChI=1S/C18H22BrN3O2S2/c1-17(2)7-10-11(8-17)13(25-12(10)9-5-6-9)22-15(19)20-21-16(22)26-18(3,4)14(23)24/h9H,5-8H2,1-4H3,(H,23,24)
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Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472391
PNG
(US10829483, Compound WX001)
Show SMILES OC(=O)CSc1nnc(Br)n1-c1sc(C2CC2)c2CCCCc12
Show InChI InChI=1S/C15H16BrN3O2S2/c16-14-17-18-15(22-7-11(20)21)19(14)13-10-4-2-1-3-9(10)12(23-13)8-5-6-8/h8H,1-7H2,(H,20,21)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472397
PNG
(US10829483, Compound WX005)
Show SMILES CC(C)(Sc1nnc(Br)n1-c1sc(c2CCCCc12)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C20H20BrN3O2S2/c1-20(2,17(25)26)28-19-23-22-18(21)24(19)16-14-11-7-6-10-13(14)15(27-16)12-8-4-3-5-9-12/h3-5,8-9H,6-7,10-11H2,1-2H3,(H,25,26)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472420
PNG
(US10829483, Compound WX026)
Show SMILES CC(Sc1nnc(Br)n1-c1sc(C2CC2)c2CCCCc12)C(O)=O
Show InChI InChI=1S/C16H18BrN3O2S2/c1-8(14(21)22)23-16-19-18-15(17)20(16)13-11-5-3-2-4-10(11)12(24-13)9-6-7-9/h8-9H,2-7H2,1H3,(H,21,22)
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Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472423
PNG
(US10829483, Compound WX028)
Show SMILES CC(C)C(Sc1nnc(Br)n1-c1sc(C2CC2)c2CCCCc12)C(O)=O
Show InChI InChI=1S/C18H22BrN3O2S2/c1-9(2)13(16(23)24)26-18-21-20-17(19)22(18)15-12-6-4-3-5-11(12)14(25-15)10-7-8-10/h9-10,13H,3-8H2,1-2H3,(H,23,24)
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Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472424
PNG
(US10829483, Compound WX029)
Show SMILES OC(=O)C1(CCC1)Sc1nnc(Br)n1-c1sc(C2CC2)c2CCCCc12
Show InChI InChI=1S/C18H20BrN3O2S2/c19-16-20-21-17(26-18(15(23)24)8-3-9-18)22(16)14-12-5-2-1-4-11(12)13(25-14)10-6-7-10/h10H,1-9H2,(H,23,24)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472468
PNG
(US10829483, Compound WX060)
Show SMILES OC(=O)C1(CCCC1)Sc1nnc(Br)n1-c1sc(C2CC2)c2CCCc12
Show InChI InChI=1S/C18H20BrN3O2S2/c19-16-20-21-17(26-18(15(23)24)8-1-2-9-18)22(16)14-12-5-3-4-11(12)13(25-14)10-6-7-10/h10H,1-9H2,(H,23,24)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472481
PNG
(US10829483, Compound WX069)
Show SMILES OC(=O)C1(CCCC1)Sc1nnc(Br)n1-c1cc(Cl)c(s1)C1CC1
Show InChI InChI=1S/C15H15BrClN3O2S2/c16-13-18-19-14(24-15(12(21)22)5-1-2-6-15)20(13)10-7-9(17)11(23-10)8-3-4-8/h7-8H,1-6H2,(H,21,22)
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Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472501
PNG
(US10829483, Compound WX088)
Show SMILES CC(C)C(Sc1nnc(Br)n1-c1cc(C)c(s1)C1CC1)C(O)=O
Show InChI InChI=1S/C15H18BrN3O2S2/c1-7(2)11(13(20)21)23-15-18-17-14(16)19(15)10-6-8(3)12(22-10)9-4-5-9/h6-7,9,11H,4-5H2,1-3H3,(H,20,21)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472506
PNG
(US10829483, Compound WX091)
Show SMILES CCC(Sc1nnc(Br)n1-c1cc(C)c(s1)C1CC1)C(O)=O
Show InChI InChI=1S/C14H16BrN3O2S2/c1-3-9(12(19)20)21-14-17-16-13(15)18(14)10-6-7(2)11(22-10)8-4-5-8/h6,8-9H,3-5H2,1-2H3,(H,19,20)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472422
PNG
(US10829483, Compound WX027)
Show SMILES CC(C)(Sc1nnc(Br)n1-c1sc(C2CC2)c2CCCCc12)C(O)=O
Show InChI InChI=1S/C17H20BrN3O2S2/c1-17(2,14(22)23)25-16-20-19-15(18)21(16)13-11-6-4-3-5-10(11)12(24-13)9-7-8-9/h9H,3-8H2,1-2H3,(H,22,23)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472469
PNG
(US10829483, Compound WX061)
Show SMILES CC(Sc1nnc(Br)n1-c1sc(C2CC2)c2CCCc12)C(O)=O
Show InChI InChI=1S/C15H16BrN3O2S2/c1-7(13(20)21)22-15-18-17-14(16)19(15)12-10-4-2-3-9(10)11(23-12)8-5-6-8/h7-8H,2-6H2,1H3,(H,20,21)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472476
PNG
(US10829483, Compound WX067)
Show SMILES CC(C)(Sc1nnc(Br)n1-c1cc(Cl)c(s1)C1CC1)C(O)=O
Show InChI InChI=1S/C13H13BrClN3O2S2/c1-13(2,10(19)20)22-12-17-16-11(14)18(12)8-5-7(15)9(21-8)6-3-4-6/h5-6H,3-4H2,1-2H3,(H,19,20)
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Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472405
PNG
(US10829483, Compound WX013)
Show SMILES CC(C)(Sc1nnc(Br)n1-c1sc(c2CCCCc12)-c1ccc(F)c(F)c1)C(O)=O
Show InChI InChI=1S/C20H18BrF2N3O2S2/c1-20(2,17(27)28)30-19-25-24-18(21)26(19)16-12-6-4-3-5-11(12)15(29-16)10-7-8-13(22)14(23)9-10/h7-9H,3-6H2,1-2H3,(H,27,28)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472432
PNG
(US10829483, Compound WX034)
Show SMILES CC(C)(Sc1nnc(Br)n1-c1sc(C2CC2)c2CCC(C)(C)Cc12)C(O)=O
Show InChI InChI=1S/C19H24BrN3O2S2/c1-18(2)8-7-11-12(9-18)14(26-13(11)10-5-6-10)23-16(20)21-22-17(23)27-19(3,4)15(24)25/h10H,5-9H2,1-4H3,(H,24,25)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472470
PNG
(US10829483, Compound WX062)
Show SMILES CC(C)(Sc1nnc(Br)n1-c1sc(C2CC2)c2CCCc12)C(O)=O
Show InChI InChI=1S/C16H18BrN3O2S2/c1-16(2,13(21)22)24-15-19-18-14(17)20(15)12-10-5-3-4-9(10)11(23-12)8-6-7-8/h8H,3-7H2,1-2H3,(H,21,22)
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Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472403
PNG
(US10829483, Compound WX011)
Show SMILES CC(C)(Sc1nnc(Br)n1-c1sc(c2CCCCc12)-c1ccc(Cl)c(Cl)c1)C(O)=O
Show InChI InChI=1S/C20H18BrCl2N3O2S2/c1-20(2,17(27)28)30-19-25-24-18(21)26(19)16-12-6-4-3-5-11(12)15(29-16)10-7-8-13(22)14(23)9-10/h7-9H,3-6H2,1-2H3,(H,27,28)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472404
PNG
(US10829483, Compound WX012)
Show SMILES COc1ccc(cc1Br)-c1sc(c2CCCCc12)-n1c(Br)nnc1SC(C)C(O)=O
Show InChI InChI=1S/C20H19Br2N3O3S2/c1-10(18(26)27)29-20-24-23-19(22)25(20)17-13-6-4-3-5-12(13)16(30-17)11-7-8-15(28-2)14(21)9-11/h7-10H,3-6H2,1-2H3,(H,26,27)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472425
PNG
(US10829483, Compound WX030)
Show SMILES OC(=O)C1(CCCC1)Sc1nnc(Br)n1-c1sc(C2CC2)c2CCCCc12
Show InChI InChI=1S/C19H22BrN3O2S2/c20-17-21-22-18(27-19(16(24)25)9-3-4-10-19)23(17)15-13-6-2-1-5-12(13)14(26-15)11-7-8-11/h11H,1-10H2,(H,24,25)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472433
PNG
(US10829483, Compound WX035)
Show SMILES CC(C)(Sc1nnc(Br)n1-c1sc(C2CC2)c2CC(C)(C)CCc12)C(O)=O
Show InChI InChI=1S/C19H24BrN3O2S2/c1-18(2)8-7-11-12(9-18)13(10-5-6-10)26-14(11)23-16(20)21-22-17(23)27-19(3,4)15(24)25/h10H,5-9H2,1-4H3,(H,24,25)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472509
PNG
(US10829483, Compound WX093)
Show SMILES Cc1cc(sc1C1CC1)-n1c(Br)nnc1SC1(CCC1)C(O)=O
Show InChI InChI=1S/C15H16BrN3O2S2/c1-8-7-10(22-11(8)9-3-4-9)19-13(16)17-18-14(19)23-15(12(20)21)5-2-6-15/h7,9H,2-6H2,1H3,(H,20,21)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472510
PNG
(US10829483, Compound WX094)
Show SMILES CC(Sc1nnc(Br)n1-c1cc(C)c(s1)C1CC1)C(O)=O
Show InChI InChI=1S/C13H14BrN3O2S2/c1-6-5-9(21-10(6)8-3-4-8)17-12(14)15-16-13(17)20-7(2)11(18)19/h5,7-8H,3-4H2,1-2H3,(H,18,19)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472475
PNG
(US10829483, Compound WX066)
Show SMILES CC1(C)Cc2c(C1)c(sc2C1CC1)-n1c(Br)nnc1SC1(CCC1)C(O)=O
Show InChI InChI=1S/C19H22BrN3O2S2/c1-18(2)8-11-12(9-18)14(26-13(11)10-4-5-10)23-16(20)21-22-17(23)27-19(15(24)25)6-3-7-19/h10H,3-9H2,1-2H3,(H,24,25)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472401
PNG
(US10829483, Compound WX009)
Show SMILES OC(=O)CSc1nnc(Br)n1-c1sc(c2CCCCc12)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C18H14BrF2N3O2S2/c19-17-22-23-18(27-8-14(25)26)24(17)16-13-4-2-1-3-12(13)15(28-16)9-5-10(20)7-11(21)6-9/h5-7H,1-4,8H2,(H,25,26)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472406
PNG
(US10829483, Compound WX014)
Show SMILES CC(Sc1nnc(Br)n1-c1sc(c2CCCCc12)-c1ccc(cc1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C20H17BrF3N3O2S2/c1-10(17(28)29)30-19-26-25-18(21)27(19)16-14-5-3-2-4-13(14)15(31-16)11-6-8-12(9-7-11)20(22,23)24/h6-10H,2-5H2,1H3,(H,28,29)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472431
PNG
(US10829483, Compound WX033)
Show SMILES CC(C)(Sc1nnc(Br)n1-c1sc(C2CC2)c2CC(F)(F)CCc12)C(O)=O
Show InChI InChI=1S/C17H18BrF2N3O2S2/c1-16(2,13(24)25)27-15-22-21-14(18)23(15)12-9-5-6-17(19,20)7-10(9)11(26-12)8-3-4-8/h8H,3-7H2,1-2H3,(H,24,25)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472472
PNG
(US10829483, Compound WX063)
Show SMILES CCC(C)(Sc1nnc(Br)n1-c1sc(C2CC2)c2CCCc12)C(O)=O
Show InChI InChI=1S/C17H20BrN3O2S2/c1-3-17(2,14(22)23)25-16-20-19-15(18)21(16)13-11-6-4-5-10(11)12(24-13)9-7-8-9/h9H,3-8H2,1-2H3,(H,22,23)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472427
PNG
(US10829483, Compound WX032)
Show SMILES C[C@H](Sc1nnc(Br)n1-c1sc(C2CC2)c2CCCCc12)C(O)=O
Show InChI InChI=1S/C16H18BrN3O2S2/c1-8(14(21)22)23-16-19-18-15(17)20(16)13-11-5-3-2-4-10(11)12(24-13)9-6-7-9/h8-9H,2-7H2,1H3,(H,21,22)/t8-/m0/s1
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472395
PNG
(US10829483, Compound WX003)
Show SMILES OC(=O)CSc1nnc(Br)n1-c1sc(c2CCCCc12)-c1ccccc1
Show InChI InChI=1S/C18H16BrN3O2S2/c19-17-20-21-18(25-10-14(23)24)22(17)16-13-9-5-4-8-12(13)15(26-16)11-6-2-1-3-7-11/h1-3,6-7H,4-5,8-10H2,(H,23,24)
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n/an/a 2.75E+3n/an/an/an/an/an/a


TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472479
PNG
(US10829483, Compound WX068)
Show SMILES OC(=O)C1(CCC1)Sc1nnc(Br)n1-c1cc(Cl)c(s1)C1CC1
Show InChI InChI=1S/C14H13BrClN3O2S2/c15-12-17-18-13(23-14(11(20)21)4-1-5-14)19(12)9-6-8(16)10(22-9)7-2-3-7/h6-7H,1-5H2,(H,20,21)
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n/an/a 2.75E+3n/an/an/an/an/an/a


TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472502
PNG
(US10829483, Compound WX089)
Show SMILES Cc1cc(sc1C1CC1)-n1c(Br)nnc1SC(C)(C)C(O)=O
Show InChI InChI=1S/C14H16BrN3O2S2/c1-7-6-9(21-10(7)8-4-5-8)18-12(15)16-17-13(18)22-14(2,3)11(19)20/h6,8H,4-5H2,1-3H3,(H,19,20)
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n/an/a 2.75E+3n/an/an/an/an/an/a


TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472503
PNG
(US10829483, Compound WX090)
Show SMILES Cc1cc(sc1C1CC1)-n1c(Br)nnc1SC(C(O)=O)c1ccccc1
Show InChI InChI=1S/C18H16BrN3O2S2/c1-10-9-13(25-14(10)12-7-8-12)22-17(19)20-21-18(22)26-15(16(23)24)11-5-3-2-4-6-11/h2-6,9,12,15H,7-8H2,1H3,(H,23,24)
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n/an/a 2.75E+3n/an/an/an/an/an/a


TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472408
PNG
(US10829483, Compound WX016)
Show SMILES COc1ccc(cc1)-c1sc(c2CCCCc12)-n1c(Br)nnc1SC(C)C(O)=O
Show InChI InChI=1S/C20H20BrN3O3S2/c1-11(18(25)26)28-20-23-22-19(21)24(20)17-15-6-4-3-5-14(15)16(29-17)12-7-9-13(27-2)10-8-12/h7-11H,3-6H2,1-2H3,(H,25,26)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472411
PNG
(US10829483, Compound WX018)
Show SMILES CC(Sc1nnc(Br)n1-c1sc(c2CCCCc12)-c1ccc(Cl)c(Cl)c1)C(O)=O
Show InChI InChI=1S/C19H16BrCl2N3O2S2/c1-9(17(26)27)28-19-24-23-18(20)25(19)16-12-5-3-2-4-11(12)15(29-16)10-6-7-13(21)14(22)8-10/h6-9H,2-5H2,1H3,(H,26,27)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472473
PNG
(US10829483, Compound WX064)
Show SMILES OC(=O)C(Sc1nnc(Br)n1-c1sc(C2CC2)c2CCCc12)c1ccccc1
Show InChI InChI=1S/C20H18BrN3O2S2/c21-19-22-23-20(28-16(18(25)26)11-5-2-1-3-6-11)24(19)17-14-8-4-7-13(14)15(27-17)12-9-10-12/h1-3,5-6,12,16H,4,7-10H2,(H,25,26)
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n/an/a 2.75E+3n/an/an/an/an/an/a


TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472483
PNG
(US10829483, Compound WX070)
Show SMILES CC(Sc1nnc(Br)n1-c1cc(Cl)c(s1)C1CC1)C(O)=O
Show InChI InChI=1S/C12H11BrClN3O2S2/c1-5(10(18)19)20-12-16-15-11(13)17(12)8-4-7(14)9(21-8)6-2-3-6/h4-6H,2-3H2,1H3,(H,18,19)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472489
PNG
(US10829483, Compound WX076)
Show SMILES CCOC(=O)C(C)(C)Sc1nncn1-c1cc(Br)c(s1)C1CC1
Show InChI InChI=1S/C15H18BrN3O2S2/c1-4-21-13(20)15(2,3)23-14-18-17-8-19(14)11-7-10(16)12(22-11)9-5-6-9/h7-9H,4-6H2,1-3H3
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n/an/a 2.75E+3n/an/an/an/an/an/a


TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472398
PNG
(US10829483, Compound WX006)
Show SMILES OC(=O)CSc1nnc(Br)n1-c1sc(c2CCCCc12)-c1ccc(F)cc1
Show InChI InChI=1S/C18H15BrFN3O2S2/c19-17-21-22-18(26-9-14(24)25)23(17)16-13-4-2-1-3-12(13)15(27-16)10-5-7-11(20)8-6-10/h5-8H,1-4,9H2,(H,24,25)
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n/an/a 2.75E+3n/an/an/an/an/an/a


TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472400
PNG
(US10829483, Compound WX008)
Show SMILES OC(=O)CSc1nnc(Br)n1-c1sc(c2CCCCc12)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C18H14BrF2N3O2S2/c19-17-22-23-18(27-8-14(25)26)24(17)16-11-4-2-1-3-10(11)15(28-16)9-5-6-12(20)13(21)7-9/h5-7H,1-4,8H2,(H,25,26)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472402
PNG
(US10829483, Compound WX010)
Show SMILES CC(C)(Sc1nnc(Br)n1-c1sc(c2CCCCc12)-c1ccc(cc1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C21H19BrF3N3O2S2/c1-20(2,17(29)30)32-19-27-26-18(22)28(19)16-14-6-4-3-5-13(14)15(31-16)11-7-9-12(10-8-11)21(23,24)25/h7-10H,3-6H2,1-2H3,(H,29,30)
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n/an/a 2.75E+3n/an/an/an/an/an/a


TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472494
PNG
(US10829483, Compound WX081)
Show SMILES Cc1cc(sc1-c1ccccc1)-n1c(Br)nnc1SC(C)(C)C(O)=O
Show InChI InChI=1S/C17H16BrN3O2S2/c1-10-9-12(24-13(10)11-7-5-4-6-8-11)21-15(18)19-20-16(21)25-17(2,3)14(22)23/h4-9H,1-3H3,(H,22,23)
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n/an/a 2.75E+3n/an/an/an/an/an/a


TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472399
PNG
(US10829483, Compound WX007)
Show SMILES OC(=O)CSc1nnc(Br)n1-c1sc(c2CCCCc12)-c1cccc(F)c1
Show InChI InChI=1S/C18H15BrFN3O2S2/c19-17-21-22-18(26-9-14(24)25)23(17)16-13-7-2-1-6-12(13)15(27-16)10-4-3-5-11(20)8-10/h3-5,8H,1-2,6-7,9H2,(H,24,25)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472396
PNG
(US10829483, Compound WX004)
Show SMILES CC(Sc1nnc(Br)n1-c1sc(c2CCCCc12)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C19H18BrN3O2S2/c1-11(17(24)25)26-19-22-21-18(20)23(19)16-14-10-6-5-9-13(14)15(27-16)12-7-3-2-4-8-12/h2-4,7-8,11H,5-6,9-10H2,1H3,(H,24,25)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472417
PNG
(US10829483, Compound WX023)
Show SMILES CN(C)c1ccc(cc1Br)-c1sc(c2CCCCc12)-n1cnnc1SC(C)(C)C(O)=O
Show InChI InChI=1S/C22H25BrN4O2S2/c1-22(2,20(28)29)31-21-25-24-12-27(21)19-15-8-6-5-7-14(15)18(30-19)13-9-10-17(26(3)4)16(23)11-13/h9-12H,5-8H2,1-4H3,(H,28,29)
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n/an/a 2.75E+3n/an/an/an/an/an/a


TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472488
PNG
(US10829483, Compound WX075)
Show SMILES COC(=O)C(C)Sc1nncn1-c1cc(Br)c(s1)-c1ccccc1
Show InChI InChI=1S/C16H14BrN3O2S2/c1-10(15(21)22-2)23-16-19-18-9-20(16)13-8-12(17)14(24-13)11-6-4-3-5-7-11/h3-10H,1-2H3
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n/an/a 2.75E+3n/an/an/an/an/an/a


TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472492
PNG
(US10829483, Compound WX079)
Show SMILES Cc1cc(sc1-c1ccccc1)-n1c(Br)nnc1SCC(O)=O
Show InChI InChI=1S/C15H12BrN3O2S2/c1-9-7-11(23-13(9)10-5-3-2-4-6-10)19-14(16)17-18-15(19)22-8-12(20)21/h2-7H,8H2,1H3,(H,20,21)
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n/an/a 2.75E+3n/an/an/an/an/an/a


TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472500
PNG
(US10829483, Compound WX087)
Show SMILES CC(Sc1nnc(Br)n1-c1cc(C)c(s1)-c1cccc(F)c1)C(O)=O
Show InChI InChI=1S/C16H13BrFN3O2S2/c1-8-6-12(25-13(8)10-4-3-5-11(18)7-10)21-15(17)19-20-16(21)24-9(2)14(22)23/h3-7,9H,1-2H3,(H,22,23)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472418
PNG
(US10829483, Compound WX024)
Show SMILES CNc1c(Br)cc(cc1Br)-c1sc(c2CCCCc12)-n1cnnc1SC(C)(C)C(O)=O
Show InChI InChI=1S/C21H22Br2N4O2S2/c1-21(2,19(28)29)31-20-26-25-10-27(20)18-13-7-5-4-6-12(13)17(30-18)11-8-14(22)16(24-3)15(23)9-11/h8-10,24H,4-7H2,1-3H3,(H,28,29)
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n/an/a 2.75E+3n/an/an/an/an/an/a


TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472465
PNG
(US10829483, Compound WX057)
Show SMILES CN(C)c1ccc(cc1Br)-c1sc(c2CCCc12)-n1cnnc1SCC(O)=O
Show InChI InChI=1S/C19H19BrN4O2S2/c1-23(2)15-7-6-11(8-14(15)20)17-12-4-3-5-13(12)18(28-17)24-10-21-22-19(24)27-9-16(25)26/h6-8,10H,3-5,9H2,1-2H3,(H,25,26)
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n/an/a 2.75E+3n/an/an/an/an/an/a


TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472484
PNG
(US10829483, Compound WX071)
Show SMILES COc1ccc(cc1)-c1sc(cc1Cl)-n1c(Br)nnc1SC(C)(C)C(O)=O
Show InChI InChI=1S/C17H15BrClN3O3S2/c1-17(2,14(23)24)27-16-21-20-15(18)22(16)12-8-11(19)13(26-12)9-4-6-10(25-3)7-5-9/h4-8H,1-3H3,(H,23,24)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472493
PNG
(US10829483, Compound WX080)
Show SMILES CC(Sc1nnc(Br)n1-c1cc(C)c(s1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C16H14BrN3O2S2/c1-9-8-12(24-13(9)11-6-4-3-5-7-11)20-15(17)18-19-16(20)23-10(2)14(21)22/h3-8,10H,1-2H3,(H,21,22)
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n/an/a 2.75E+3n/an/an/an/an/an/a


TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472412
PNG
(US10829483, Compound WX019)
Show SMILES OC(=O)CSc1nnc(Br)n1-c1sc(c2CCCCc12)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H14BrCl2N3O2S2/c19-17-22-23-18(27-8-14(25)26)24(17)16-11-4-2-1-3-10(11)15(28-16)9-5-6-12(20)13(21)7-9/h5-7H,1-4,8H2,(H,25,26)
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n/an/a 2.75E+3n/an/an/an/an/an/a


TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472409
PNG
(US10829483, Compound WX017)
Show SMILES COc1ccc(cc1)-c1sc(c2CCCCc12)-n1c(Br)nnc1SCC(O)=O
Show InChI InChI=1S/C19H18BrN3O3S2/c1-26-12-8-6-11(7-9-12)16-13-4-2-3-5-14(13)17(28-16)23-18(20)21-22-19(23)27-10-15(24)25/h6-9H,2-5,10H2,1H3,(H,24,25)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472499
PNG
(US10829483, Compound WX086)
Show SMILES CC(Sc1nnc(Br)n1-c1cc(C)c(s1)-c1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C16H13BrClN3O2S2/c1-8-7-12(25-13(8)10-3-5-11(18)6-4-10)21-15(17)19-20-16(21)24-9(2)14(22)23/h3-7,9H,1-2H3,(H,22,23)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472519
PNG
(US10829483, Compound WX102)
Show SMILES CC(C)(Sc1nnc(Br)n1-c1sc(C2CC2)c2CCCc12)C(=O)NO
Show InChI InChI=1S/C16H19BrN4O2S2/c1-16(2,13(22)20-23)25-15-19-18-14(17)21(15)12-10-5-3-4-9(10)11(24-12)8-6-7-8/h8,23H,3-7H2,1-2H3,(H,20,22)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472520
PNG
(US10829483, Compound WX103)
Show SMILES CCOC(=O)C(C)(C)Sc1nncn1-c1sc(C(=O)NC(O)CCBr)c2CCCCc12
Show InChI InChI=1S/C20H27BrN4O4S2/c1-4-29-18(28)20(2,3)31-19-24-22-11-25(19)17-13-8-6-5-7-12(13)15(30-17)16(27)23-14(26)9-10-21/h11,14,26H,4-10H2,1-3H3,(H,23,27)
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n/an/a 2.75E+3n/an/an/an/an/an/a


TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472415
PNG
(US10829483, Compound WX022)
Show SMILES OC(=O)CSc1nncn1-c1sc(c2CCCCc12)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C18H15F2N3O2S2/c19-11-5-10(6-12(20)7-11)16-13-3-1-2-4-14(13)17(27-16)23-9-21-22-18(23)26-8-15(24)25/h5-7,9H,1-4,8H2,(H,24,25)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472518
PNG
(US10829483, Compound WX101)
Show SMILES CC(C)c1nnc(SCC(O)=O)n1-c1sc(C2CC2)c2CCCc12
Show InChI InChI=1S/C17H21N3O2S2/c1-9(2)15-18-19-17(23-8-13(21)22)20(15)16-12-5-3-4-11(12)14(24-16)10-6-7-10/h9-10H,3-8H2,1-2H3,(H,21,22)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472452
PNG
(US10829483, Compound WX049)
Show SMILES COc1ccc(cc1)-c1sc(c2CCCc12)-n1cnnc1SCC(O)=O
Show InChI InChI=1S/C18H17N3O3S2/c1-24-12-7-5-11(6-8-12)16-13-3-2-4-14(13)17(26-16)21-10-19-20-18(21)25-9-15(22)23/h5-8,10H,2-4,9H2,1H3,(H,22,23)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472458
PNG
(US10829483, Compound WX052)
Show SMILES OC(=O)CSc1nncn1-c1sc(c2CCCc12)-c1cccc(Cl)c1
Show InChI InChI=1S/C17H14ClN3O2S2/c18-11-4-1-3-10(7-11)15-12-5-2-6-13(12)16(25-15)21-9-19-20-17(21)24-8-14(22)23/h1,3-4,7,9H,2,5-6,8H2,(H,22,23)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472462
PNG
(US10829483, Compound WX054)
Show SMILES OC(=O)CSc1nncn1-c1sc(c2CCCc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C17H14ClN3O2S2/c18-11-6-4-10(5-7-11)15-12-2-1-3-13(12)16(25-15)21-9-19-20-17(21)24-8-14(22)23/h4-7,9H,1-3,8H2,(H,22,23)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472466
PNG
(US10829483, Compound WX058)
Show SMILES OC(=O)CSc1nnc(Br)n1-c1sc(C2CC2)c2CCCc12
Show InChI InChI=1S/C14H14BrN3O2S2/c15-13-16-17-14(21-6-10(19)20)18(13)12-9-3-1-2-8(9)11(22-12)7-4-5-7/h7H,1-6H2,(H,19,20)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472517
PNG
(US10829483, Compound WX100)
Show SMILES CCOC(=O)C(C)(C)Sc1nnc(Br)n1-c1sc(C(=O)Nc2ccc(F)c(F)c2)c2CCCCc12
Show InChI InChI=1S/C23H23BrF2N4O3S2/c1-4-33-20(32)23(2,3)35-22-29-28-21(24)30(22)19-14-8-6-5-7-13(14)17(34-19)18(31)27-12-9-10-15(25)16(26)11-12/h9-11H,4-8H2,1-3H3,(H,27,31)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472407
PNG
(US10829483, Compound WX015)
Show SMILES CC(Sc1nnc(Br)n1-c1sc(c2CCCCc12)-c1ccc(cc1)S(C)(=O)=O)C(O)=O
Show InChI InChI=1S/C20H20BrN3O4S3/c1-11(18(25)26)29-20-23-22-19(21)24(20)17-15-6-4-3-5-14(15)16(30-17)12-7-9-13(10-8-12)31(2,27)28/h7-11H,3-6H2,1-2H3,(H,25,26)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472464
PNG
(US10829483, Compound WX056)
Show SMILES Cn1cc(cn1)-c1sc(c2CCCc12)-n1cnnc1SCC(O)=O
Show InChI InChI=1S/C15H15N5O2S2/c1-19-6-9(5-17-19)13-10-3-2-4-11(10)14(24-13)20-8-16-18-15(20)23-7-12(21)22/h5-6,8H,2-4,7H2,1H3,(H,21,22)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472486
PNG
(US10829483, Compound WX073)
Show SMILES COC(=O)CSc1nncn1-c1cc(Br)c(s1)-c1ccccc1
Show InChI InChI=1S/C15H12BrN3O2S2/c1-21-13(20)8-22-15-18-17-9-19(15)12-7-11(16)14(23-12)10-5-3-2-4-6-10/h2-7,9H,8H2,1H3
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472393
PNG
(US10829483, Compound WX002)
Show SMILES OC(=O)CSc1nncn1-c1sc(C2CC2)c2CCCCc12
Show InChI InChI=1S/C15H17N3O2S2/c19-12(20)7-21-15-17-16-8-18(15)14-11-4-2-1-3-10(11)13(22-14)9-5-6-9/h8-9H,1-7H2,(H,19,20)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472440
PNG
(US10829483, Compound WX040)
Show SMILES OC(=O)CSc1nnc(Br)n1-c1sc(c2CCCc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C17H13BrClN3O2S2/c18-16-20-21-17(25-8-13(23)24)22(16)15-12-3-1-2-11(12)14(26-15)9-4-6-10(19)7-5-9/h4-7H,1-3,8H2,(H,23,24)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472456
PNG
(US10829483, Compound WX050)
Show SMILES Cc1ccc(cc1)-c1sc(c2CCCc12)-n1cnnc1SCC(O)=O
Show InChI InChI=1S/C18H17N3O2S2/c1-11-5-7-12(8-6-11)16-13-3-2-4-14(13)17(25-16)21-10-19-20-18(21)24-9-15(22)23/h5-8,10H,2-4,9H2,1H3,(H,22,23)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472457
PNG
(US10829483, Compound WX051)
Show SMILES OC(=O)CSc1nncn1-c1sc(c2CCCc12)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C18H14F3N3O2S2/c19-18(20,21)11-6-4-10(5-7-11)15-12-2-1-3-13(12)16(28-15)24-9-22-23-17(24)27-8-14(25)26/h4-7,9H,1-3,8H2,(H,25,26)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472461
PNG
(US10829483, Compound WX053)
Show SMILES CN(C)c1ccc(cc1)-c1sc(c2CCCc12)-n1cnnc1SCC(O)=O
Show InChI InChI=1S/C19H20N4O2S2/c1-22(2)13-8-6-12(7-9-13)17-14-4-3-5-15(14)18(27-17)23-11-20-21-19(23)26-10-16(24)25/h6-9,11H,3-5,10H2,1-2H3,(H,24,25)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472485
PNG
(US10829483, Compound WX072)
Show SMILES CCOC(=O)CSc1nncn1-c1cc(Br)c(s1)C1CC1
Show InChI InChI=1S/C13H14BrN3O2S2/c1-2-19-11(18)6-20-13-16-15-7-17(13)10-5-9(14)12(21-10)8-3-4-8/h5,7-8H,2-4,6H2,1H3
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472435
PNG
(US10829483, Compound WX037)
Show SMILES OC(=O)CSc1nnc(Br)n1-c1sc(c2CCCc12)-c1ccccc1
Show InChI InChI=1S/C17H14BrN3O2S2/c18-16-19-20-17(24-9-13(22)23)21(16)15-12-8-4-7-11(12)14(25-15)10-5-2-1-3-6-10/h1-3,5-6H,4,7-9H2,(H,22,23)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472487
PNG
(US10829483, Compound WX074)
Show SMILES CCOC(=O)C(C)Sc1nncn1-c1cc(Br)c(s1)C1CC1
Show InChI InChI=1S/C14H16BrN3O2S2/c1-3-20-13(19)8(2)21-14-17-16-7-18(14)11-6-10(15)12(22-11)9-4-5-9/h6-9H,3-5H2,1-2H3
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472495
PNG
(US10829483, Compound WX082)
Show SMILES Cc1cc(sc1-c1ccc(F)cc1)-n1c(Br)nnc1SCC(O)=O
Show InChI InChI=1S/C15H11BrFN3O2S2/c1-8-6-11(24-13(8)9-2-4-10(17)5-3-9)20-14(16)18-19-15(20)23-7-12(21)22/h2-6H,7H2,1H3,(H,21,22)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472413
PNG
(US10829483, Compound WX020)
Show SMILES OC(=O)CSc1nncn1-c1sc(c2CCCCc12)-c1cccc(F)c1
Show InChI InChI=1S/C18H16FN3O2S2/c19-12-5-3-4-11(8-12)16-13-6-1-2-7-14(13)17(26-16)22-10-20-21-18(22)25-9-15(23)24/h3-5,8,10H,1-2,6-7,9H2,(H,23,24)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472414
PNG
(US10829483, Compound WX021)
Show SMILES OC(=O)CSc1nncn1-c1sc(c2CCCCc12)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C18H15F2N3O2S2/c19-13-6-5-10(7-14(13)20)16-11-3-1-2-4-12(11)17(27-16)23-9-21-22-18(23)26-8-15(24)25/h5-7,9H,1-4,8H2,(H,24,25)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472434
PNG
(US10829483, Compound WX036)
Show SMILES CC(Sc1nncn1-c1sc(C2CC2)c2CCCCc12)C(O)=O
Show InChI InChI=1S/C16H19N3O2S2/c1-9(15(20)21)22-16-18-17-8-19(16)14-12-5-3-2-4-11(12)13(23-14)10-6-7-10/h8-10H,2-7H2,1H3,(H,20,21)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472450
PNG
(US10829483, Compound WX047)
Show SMILES Cn1cc(cn1)-c1sc(c2CCCc12)-n1c(Br)nnc1SCC(O)=O
Show InChI InChI=1S/C15H14BrN5O2S2/c1-20-6-8(5-17-20)12-9-3-2-4-10(9)13(25-12)21-14(16)18-19-15(21)24-7-11(22)23/h5-6H,2-4,7H2,1H3,(H,22,23)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472496
PNG
(US10829483, Compound WX083)
Show SMILES COc1ccc(cc1)-c1sc(cc1C)-n1c(Br)nnc1SCC(O)=O
Show InChI InChI=1S/C16H14BrN3O3S2/c1-9-7-12(20-15(17)18-19-16(20)24-8-13(21)22)25-14(9)10-3-5-11(23-2)6-4-10/h3-7H,8H2,1-2H3,(H,21,22)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472498
PNG
(US10829483, Compound WX085)
Show SMILES Cc1cc(sc1-c1ccc(cc1)C(C)(C)C)-n1c(Br)nnc1SCC(O)=O
Show InChI InChI=1S/C19H20BrN3O2S2/c1-11-9-14(23-17(20)21-22-18(23)26-10-15(24)25)27-16(11)12-5-7-13(8-6-12)19(2,3)4/h5-9H,10H2,1-4H3,(H,24,25)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472511
PNG
(US10829483, Compound WX095)
Show SMILES Cc1cc(sc1-c1ccc(F)cc1)-n1cnnc1SCC(O)=O
Show InChI InChI=1S/C15H12FN3O2S2/c1-9-6-12(19-8-17-18-15(19)22-7-13(20)21)23-14(9)10-2-4-11(16)5-3-10/h2-6,8H,7H2,1H3,(H,20,21)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472513
PNG
(US10829483, Compound WX096)
Show SMILES COc1ccc(cc1)-c1sc(cc1C)-n1cnnc1SCC(O)=O
Show InChI InChI=1S/C16H15N3O3S2/c1-10-7-13(19-9-17-18-16(19)23-8-14(20)21)24-15(10)11-3-5-12(22-2)6-4-11/h3-7,9H,8H2,1-2H3,(H,20,21)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472419
PNG
(US10829483, Compound WX025)
Show SMILES CC(C)(Sc1nnc(Br)n1-c1sc(c2CCCCc12)-c1ccncn1)C(O)=O
Show InChI InChI=1S/C18H18BrN5O2S2/c1-18(2,15(25)26)28-17-23-22-16(19)24(17)14-11-6-4-3-5-10(11)13(27-14)12-7-8-20-9-21-12/h7-9H,3-6H2,1-2H3,(H,25,26)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472437
PNG
(US10829483, Compound WX038)
Show SMILES OC(=O)CSc1nnc(Br)n1-c1sc(c2CCCc12)-c1ccc(F)cc1
Show InChI InChI=1S/C17H13BrFN3O2S2/c18-16-20-21-17(25-8-13(23)24)22(16)15-12-3-1-2-11(12)14(26-15)9-4-6-10(19)7-5-9/h4-7H,1-3,8H2,(H,23,24)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472438
PNG
(US10829483, Compound WX039)
Show SMILES OC(=O)CSc1nnc(Br)n1-c1sc(c2CCCc12)-c1cccc(F)c1
Show InChI InChI=1S/C17H13BrFN3O2S2/c18-16-20-21-17(25-8-13(23)24)22(16)15-12-6-2-5-11(12)14(26-15)9-3-1-4-10(19)7-9/h1,3-4,7H,2,5-6,8H2,(H,23,24)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472490
PNG
(US10829483, Compound WX077)
Show SMILES COC(=O)C(C)(C)Sc1nncn1-c1cc(Br)c(s1)-c1ccccc1
Show InChI InChI=1S/C17H16BrN3O2S2/c1-17(2,15(22)23-3)25-16-20-19-10-21(16)13-9-12(18)14(24-13)11-7-5-4-6-8-11/h4-10H,1-3H3
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472514
PNG
(US10829483, Compound WX097)
Show SMILES Cc1cc(sc1-c1ccc(cc1)C(F)(F)F)-n1cnnc1SCC(O)=O
Show InChI InChI=1S/C16H12F3N3O2S2/c1-9-6-12(22-8-20-21-15(22)25-7-13(23)24)26-14(9)10-2-4-11(5-3-10)16(17,18)19/h2-6,8H,7H2,1H3,(H,23,24)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472516
PNG
(US10829483, Compound WX099)
Show SMILES OC(=O)CSc1nnc(Br)n1-c1sc(c2OCCOc12)-c1ccccc1
Show InChI InChI=1S/C16H12BrN3O4S2/c17-15-18-19-16(25-8-10(21)22)20(15)14-12-11(23-6-7-24-12)13(26-14)9-4-2-1-3-5-9/h1-5H,6-8H2,(H,21,22)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472444
PNG
(US10829483, Compound WX043)
Show SMILES COc1ccc(cc1)-c1sc(c2CCCc12)-n1c(Br)nnc1SCC(O)=O
Show InChI InChI=1S/C18H16BrN3O3S2/c1-25-11-7-5-10(6-8-11)15-12-3-2-4-13(12)16(27-15)22-17(19)20-21-18(22)26-9-14(23)24/h5-8H,2-4,9H2,1H3,(H,23,24)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472451
PNG
(US10829483, Compound WX048)
Show SMILES CC(C)(C)c1ccc(cc1)-c1sc(c2CCCc12)-n1cnnc1SCC(O)=O
Show InChI InChI=1S/C21H23N3O2S2/c1-21(2,3)14-9-7-13(8-10-14)18-15-5-4-6-16(15)19(28-18)24-12-22-23-20(24)27-11-17(25)26/h7-10,12H,4-6,11H2,1-3H3,(H,25,26)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472463
PNG
(US10829483, Compound WX055)
Show SMILES OC(=O)CSc1nncn1-c1sc(c2CCCc12)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H13Cl2N3O2S2/c18-12-5-4-9(6-13(12)19)15-10-2-1-3-11(10)16(26-15)22-8-20-21-17(22)25-7-14(23)24/h4-6,8H,1-3,7H2,(H,23,24)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472497
PNG
(US10829483, Compound WX084)
Show SMILES Cc1cc(sc1-c1ccc(cc1)C(F)(F)F)-n1c(Br)nnc1SCC(O)=O
Show InChI InChI=1S/C16H11BrF3N3O2S2/c1-8-6-11(23-14(17)21-22-15(23)26-7-12(24)25)27-13(8)9-2-4-10(5-3-9)16(18,19)20/h2-6H,7H2,1H3,(H,24,25)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472442
PNG
(US10829483, Compound WX042)
Show SMILES Cc1ccc(cc1)-c1sc(c2CCCc12)-n1c(Br)nnc1SCC(O)=O
Show InChI InChI=1S/C18H16BrN3O2S2/c1-10-5-7-11(8-6-10)15-12-3-2-4-13(12)16(26-15)22-17(19)20-21-18(22)25-9-14(23)24/h5-8H,2-4,9H2,1H3,(H,23,24)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472446
PNG
(US10829483, Compound WX044)
Show SMILES OC(=O)CSc1nnc(Br)n1-c1sc(c2CCCc12)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C18H13BrF3N3O2S2/c19-16-23-24-17(28-8-13(26)27)25(16)15-12-3-1-2-11(12)14(29-15)9-4-6-10(7-5-9)18(20,21)22/h4-7H,1-3,8H2,(H,26,27)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472448
PNG
(US10829483, Compound WX045)
Show SMILES OC(=O)CSc1nnc(Br)n1-c1sc(c2CCCc12)-c1cccc(Cl)c1
Show InChI InChI=1S/C17H13BrClN3O2S2/c18-16-20-21-17(25-8-13(23)24)22(16)15-12-6-2-5-11(12)14(26-15)9-3-1-4-10(19)7-9/h1,3-4,7H,2,5-6,8H2,(H,23,24)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472449
PNG
(US10829483, Compound WX046)
Show SMILES CC(C)(C)c1ccc(cc1)-c1sc(c2CCCc12)-n1c(Br)nnc1SCC(O)=O
Show InChI InChI=1S/C21H22BrN3O2S2/c1-21(2,3)13-9-7-12(8-10-13)17-14-5-4-6-15(14)18(29-17)25-19(22)23-24-20(25)28-11-16(26)27/h7-10H,4-6,11H2,1-3H3,(H,26,27)
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TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472491
PNG
(US10829483, Compound WX078)
Show SMILES Cc1cc(sc1C1CC1)-n1c(Br)nnc1SCC(O)=O
Show InChI InChI=1S/C12H12BrN3O2S2/c1-6-4-8(20-10(6)7-2-3-7)16-11(13)14-15-12(16)19-5-9(17)18/h4,7H,2-3,5H2,1H3,(H,17,18)
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DrugBank
antibodypedia
GoogleScholar
UniChem
n/an/a>5.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472515
PNG
(US10829483, Compound WX098)
Show SMILES Cc1cc(sc1-c1ccc(cc1)C(C)(C)C)-n1cnnc1SCC(O)=O
Show InChI InChI=1S/C19H21N3O2S2/c1-12-9-15(22-11-20-21-18(22)25-10-16(23)24)26-17(12)13-5-7-14(8-6-13)19(2,3)4/h5-9,11H,10H2,1-4H3,(H,23,24)
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KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
n/an/a>5.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM472441
PNG
(US10829483, Compound WX041)
Show SMILES OC(=O)CSc1nnc(Br)n1-c1sc(c2CCCc12)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H12BrCl2N3O2S2/c18-16-21-22-17(26-7-13(24)25)23(16)15-10-3-1-2-9(10)14(27-15)8-4-5-11(19)12(20)6-8/h4-6H,1-3,7H2,(H,24,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
n/an/a>5.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Experimental Purpose:Determination of the IC50 value of the inhibitory activity of the compound against uric acid reabsorption by the HEK293 cell lin...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%