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Patent code US10829487

Compile Data Set for Download or QSAR
Found 150 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
SOS1 and KRAS G12D


()
BDBM472582
PNG
(US10829487, Example I-61)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C12CCC(CC1)C2)c1cccc(c1F)C(F)(F)CO
Show InChI InChI=1S/C25H27F3N4O2/c1-14(17-4-3-5-19(22(17)26)25(27,28)13-33)29-23-18-12-32(24-8-6-16(11-24)7-9-24)21(34)10-20(18)30-15(2)31-23/h3-5,10,12,14,16,33H,6-9,11,13H2,1-2H3,(H,29,30,31)/t14-,16?,24?/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 1n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472647
PNG
(US10829487, Example I-130)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C12CCC(CC1)CC2)c1cccc(c1F)C(F)(F)CO
Show InChI InChI=1S/C26H29F3N4O2/c1-15(18-4-3-5-20(23(18)27)26(28,29)14-34)30-24-19-13-33(22(35)12-21(19)31-16(2)32-24)25-9-6-17(7-10-25)8-11-25/h3-5,12-13,15,17,34H,6-11,14H2,1-2H3,(H,30,31,32)/t15-,17?,25?/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 1n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472578
PNG
(US10829487, Example I-57)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(C)CC1)c1cccc2c1CCC2(F)F
Show InChI InChI=1S/C23H24F2N4O/c1-13(15-5-4-6-18-16(15)7-8-23(18,24)25)26-21-17-12-29(22(3)9-10-22)20(30)11-19(17)27-14(2)28-21/h4-6,11-13H,7-10H2,1-3H3,(H,26,27,28)/t13-/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 2n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472606
PNG
(US10829487, Example I-89)
Show SMILES C[C@@H](Nc1nc(C)nc2c(F)c(=O)n(cc12)C1(CC1)C(F)F)c1cccc(c1F)C(F)(F)C(C)(C)O
Show InChI InChI=1S/C24H24F6N4O2/c1-11(13-6-5-7-15(16(13)25)24(29,30)22(3,4)36)31-19-14-10-34(23(8-9-23)21(27)28)20(35)17(26)18(14)32-12(2)33-19/h5-7,10-11,21,36H,8-9H2,1-4H3,(H,31,32,33)/t11-/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 2n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472605
PNG
(US10829487, Example I-88)
Show SMILES C[C@@H](Nc1nc(C)nc2c(F)c(=O)n(cc12)C1(C)CC1)c1cccc(c1F)C(F)(F)C(C)(C)O
Show InChI InChI=1S/C24H26F4N4O2/c1-12(14-7-6-8-16(17(14)25)24(27,28)22(3,4)34)29-20-15-11-32(23(5)9-10-23)21(33)18(26)19(15)30-13(2)31-20/h6-8,11-12,34H,9-10H2,1-5H3,(H,29,30,31)/t12-/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 2n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472579
PNG
(US10829487, Example I-58)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(CC1)C(F)F)c1cccc2c1CCC2(F)F
Show InChI InChI=1S/C23H22F4N4O/c1-12(14-4-3-5-17-15(14)6-7-23(17,26)27)28-20-16-11-31(22(8-9-22)21(24)25)19(32)10-18(16)29-13(2)30-20/h3-5,10-12,21H,6-9H2,1-2H3,(H,28,29,30)/t12-/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 2n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472645
PNG
(US10829487, Example I-128)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C12CCN(CC1)CC2)c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C24H25F4N5O/c1-14(16-4-3-5-18(21(16)25)24(26,27)28)29-22-17-13-33(20(34)12-19(17)30-15(2)31-22)23-6-9-32(10-7-23)11-8-23/h3-5,12-14H,6-11H2,1-2H3,(H,29,30,31)/t14-/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 2n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472641
PNG
(US10829487, Example I-124)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C12CCC(CC1)(CC2)C(=O)N(C)C)c1cccc(C(F)F)c1C
Show InChI InChI=1S/C29H35F2N5O2/c1-17-20(7-6-8-21(17)25(30)31)18(2)32-26-22-16-36(24(37)15-23(22)33-19(3)34-26)29-12-9-28(10-13-29,11-14-29)27(38)35(4)5/h6-8,15-16,18,25H,9-14H2,1-5H3,(H,32,33,34)/t18-,28?,29?/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 2n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472642
PNG
(US10829487, Example I-125)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C12CCN(CC1)CC2)c1cccc(C(F)F)c1C
Show InChI InChI=1S/C25H29F2N5O/c1-15-18(5-4-6-19(15)23(26)27)16(2)28-24-20-14-32(22(33)13-21(20)29-17(3)30-24)25-7-10-31(11-8-25)12-9-25/h4-6,13-14,16,23H,7-12H2,1-3H3,(H,28,29,30)/t16-/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 2n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472653
PNG
(US10829487, Example I-160)
Show SMILES C[C@@H](Nc1nc(C)nc2c(C)c(=O)n(cc12)C12CCN(CC1)C2)c1cccc2c1CCC2(F)F
Show InChI InChI=1S/C26H29F2N5O/c1-15-22-20(13-33(24(15)34)25-9-11-32(14-25)12-10-25)23(31-17(3)30-22)29-16(2)18-5-4-6-21-19(18)7-8-26(21,27)28/h4-6,13,16H,7-12,14H2,1-3H3,(H,29,30,31)/t16-/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 2n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472670
PNG
(US10829487, Example I-177)
Show SMILES C[C@@H](Nc1ncnc2c(C)c(=O)n(cc12)C12CCC(CC1)C2)c1cccc2c1CCC2(F)F
Show InChI InChI=1S/C26H28F2N4O/c1-15-22-20(13-32(24(15)33)25-9-6-17(12-25)7-10-25)23(30-14-29-22)31-16(2)18-4-3-5-21-19(18)8-11-26(21,27)28/h3-5,13-14,16-17H,6-12H2,1-2H3,(H,29,30,31)/t16-,17?,25?/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 2n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472539
PNG
(US10829487, Example I-19)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C12CCC(CC1)C2)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C24H25F3N4O/c1-13(16-4-3-5-17(21(16)25)22(26)27)28-23-18-12-31(24-8-6-15(11-24)7-9-24)20(32)10-19(18)29-14(2)30-23/h3-5,10,12-13,15,22H,6-9,11H2,1-2H3,(H,28,29,30)/t13-,15?,24?/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 2n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472581
PNG
(US10829487, Example I-60)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C12CCN(CC1)C2)c1cccc2c1CCC2(F)F
Show InChI InChI=1S/C25H27F2N5O/c1-15(17-4-3-5-20-18(17)6-7-25(20,26)27)28-23-19-13-32(24-8-10-31(14-24)11-9-24)22(33)12-21(19)29-16(2)30-23/h3-5,12-13,15H,6-11,14H2,1-2H3,(H,28,29,30)/t15-/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 2n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472651
PNG
(US10829487, Example I-158)
Show SMILES C[C@@H](Nc1nc(C)nc2c(C)c(=O)n(cc12)C12CCN(CC1)CC2)c1cccc(C(F)F)c1C
Show InChI InChI=1S/C26H31F2N5O/c1-15-19(6-5-7-20(15)23(27)28)17(3)29-24-21-14-33(26-8-11-32(12-9-26)13-10-26)25(34)16(2)22(21)30-18(4)31-24/h5-7,14,17,23H,8-13H2,1-4H3,(H,29,30,31)/t17-/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 2n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472540
PNG
(US10829487, Example I-20)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(C)CC1)c1cccc(C(F)F)c1C
Show InChI InChI=1S/C22H24F2N4O/c1-12-15(6-5-7-16(12)20(23)24)13(2)25-21-17-11-28(22(4)8-9-22)19(29)10-18(17)26-14(3)27-21/h5-7,10-11,13,20H,8-9H2,1-4H3,(H,25,26,27)/t13-/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472652
PNG
(US10829487, Example I-159)
Show SMILES C[C@@H](Nc1nc(C)nc2c(C)c(=O)n(cc12)C12CCN(CC1)CC2)c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C26H30F3N5O/c1-15-19(6-5-7-21(15)26(27,28)29)17(3)30-23-20-14-34(25-8-11-33(12-9-25)13-10-25)24(35)16(2)22(20)31-18(4)32-23/h5-7,14,17H,8-13H2,1-4H3,(H,30,31,32)/t17-/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472541
PNG
(US10829487, Example I-21)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(CC1)C(F)F)c1cccc(C(F)F)c1C
Show InChI InChI=1S/C22H22F4N4O/c1-11-14(5-4-6-15(11)19(23)24)12(2)27-20-16-10-30(22(7-8-22)21(25)26)18(31)9-17(16)28-13(3)29-20/h4-6,9-10,12,19,21H,7-8H2,1-3H3,(H,27,28,29)/t12-/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472580
PNG
(US10829487, Example I-59)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C12CC(C1)C2)c1cccc2c1CCC2(F)F
Show InChI InChI=1S/C24H24F2N4O/c1-13(16-4-3-5-19-17(16)6-7-24(19,25)26)27-22-18-12-30(23-9-15(10-23)11-23)21(31)8-20(18)28-14(2)29-22/h3-5,8,12-13,15H,6-7,9-11H2,1-2H3,(H,27,28,29)/t13-,15?,23?/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472639
PNG
(US10829487, Example I-122)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C12CCC(O)(CC1)CC2)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C25H27F3N4O2/c1-14(16-4-3-5-17(21(16)26)22(27)28)29-23-18-13-32(20(33)12-19(18)30-15(2)31-23)24-6-9-25(34,10-7-24)11-8-24/h3-5,12-14,22,34H,6-11H2,1-2H3,(H,29,30,31)/t14-,24?,25?/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472640
PNG
(US10829487, Example I-123)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(C)CCOC1)c1cccc(C(F)F)c1C
Show InChI InChI=1S/C23H26F2N4O2/c1-13-16(6-5-7-17(13)21(24)25)14(2)26-22-18-11-29(23(4)8-9-31-12-23)20(30)10-19(18)27-15(3)28-22/h5-7,10-11,14,21H,8-9,12H2,1-4H3,(H,26,27,28)/t14-,23?/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472610
PNG
(US10829487, Example I-93)
Show SMILES C[C@@H](Nc1nc(C)nc2c(F)c(=O)n(cc12)C1(CC1)C(F)F)c1cccc(c1)C(F)(F)C1CCCO1
Show InChI InChI=1S/C25H25F5N4O2/c1-13(15-5-3-6-16(11-15)25(29,30)18-7-4-10-36-18)31-21-17-12-34(24(8-9-24)23(27)28)22(35)19(26)20(17)32-14(2)33-21/h3,5-6,11-13,18,23H,4,7-10H2,1-2H3,(H,31,32,33)/t13-,18?/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472592
PNG
(US10829487, Example I-73)
Show SMILES C[C@@H](Nc1ncnc2cc(=O)n(cc12)C12CCC(F)(CC1)CC2)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C24H24F4N4O/c1-14(15-3-2-4-16(20(15)25)21(26)27)31-22-17-12-32(19(33)11-18(17)29-13-30-22)24-8-5-23(28,6-9-24)7-10-24/h2-4,11-14,21H,5-10H2,1H3,(H,29,30,31)/t14-,23?,24?/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472543
PNG
(US10829487, Example I-23)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(C)CCC1)c1cccc(C(F)F)c1C
Show InChI InChI=1S/C23H26F2N4O/c1-13-16(7-5-8-17(13)21(24)25)14(2)26-22-18-12-29(23(4)9-6-10-23)20(30)11-19(18)27-15(3)28-22/h5,7-8,11-12,14,21H,6,9-10H2,1-4H3,(H,26,27,28)/t14-/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 4n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472619
PNG
(US10829487, Example I-102)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(CC1)C(F)F)c1cccc2c1OCC2(F)F
Show InChI InChI=1S/C22H20F4N4O2/c1-11(13-4-3-5-15-18(13)32-10-22(15,25)26)27-19-14-9-30(21(6-7-21)20(23)24)17(31)8-16(14)28-12(2)29-19/h3-5,8-9,11,20H,6-7,10H2,1-2H3,(H,27,28,29)/t11-/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 4n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472522
PNG
(US10829487, Example I-2)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(CF)CC1)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C21H20F4N4O/c1-11(13-4-3-5-14(18(13)23)19(24)25)26-20-15-9-29(21(10-22)6-7-21)17(30)8-16(15)27-12(2)28-20/h3-5,8-9,11,19H,6-7,10H2,1-2H3,(H,26,27,28)/t11-/m1/s1
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TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472604
PNG
(US10829487, Example I-87)
Show SMILES C[C@@H](Nc1nc(C)nc2c(F)c(=O)n(cc12)C1(CF)CC1)c1cccc(c1F)C(C)(F)F
Show InChI InChI=1S/C22H21F5N4O/c1-11(13-5-4-6-15(16(13)24)21(3,26)27)28-19-14-9-31(22(10-23)7-8-22)20(32)17(25)18(14)29-12(2)30-19/h4-6,9,11H,7-8,10H2,1-3H3,(H,28,29,30)/t11-/m1/s1
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TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472608
PNG
(US10829487, Example I-91)
Show SMILES C[C@@H](Nc1nc(C)nc2c(F)c(=O)n(cc12)C12CC(F)(C1)C2)c1cccc(c1F)C(F)(F)C(C)(C)O
Show InChI InChI=1S/C25H25F5N4O2/c1-12(14-6-5-7-16(17(14)26)25(29,30)22(3,4)36)31-20-15-8-34(24-9-23(28,10-24)11-24)21(35)18(27)19(15)32-13(2)33-20/h5-8,12,36H,9-11H2,1-4H3,(H,31,32,33)/t12-,23?,24?/m1/s1
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TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472618
PNG
(US10829487, Example I-101)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(C)CC1)c1cccc2c1OCC2(F)F
Show InChI InChI=1S/C22H22F2N4O2/c1-12(14-5-4-6-16-19(14)30-11-22(16,23)24)25-20-15-10-28(21(3)7-8-21)18(29)9-17(15)26-13(2)27-20/h4-6,9-10,12H,7-8,11H2,1-3H3,(H,25,26,27)/t12-/m1/s1
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TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472607
PNG
(US10829487, Example I-90)
Show SMILES C[C@@H](Nc1nc(C)nc2c(F)c(=O)n(cc12)C12CC(C1)C2)c1cccc(c1F)C(F)(F)C(C)(C)O
Show InChI InChI=1S/C25H26F4N4O2/c1-12(15-6-5-7-17(18(15)26)25(28,29)23(3,4)35)30-21-16-11-33(24-8-14(9-24)10-24)22(34)19(27)20(16)31-13(2)32-21/h5-7,11-12,14,35H,8-10H2,1-4H3,(H,30,31,32)/t12-,14?,24?/m1/s1
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TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472625
PNG
(US10829487, Example I-108)
Show SMILES C[C@@H](Nc1ncnc2cc(=O)n(cc12)C12CCC(CC1)C2)c1cccc2c1CCC2(F)F
Show InChI InChI=1S/C25H26F2N4O/c1-15(17-3-2-4-20-18(17)7-10-25(20,26)27)30-23-19-13-31(22(32)11-21(19)28-14-29-23)24-8-5-16(12-24)6-9-24/h2-4,11,13-16H,5-10,12H2,1H3,(H,28,29,30)/t15-,16?,24?/m1/s1
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TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472649
PNG
(US10829487, Example I-156)
Show SMILES C[C@@H](Nc1nc(C)nc2c(C)c(=O)n(cc12)C12CCC(O)(CC1)CC2)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C26H29F3N4O2/c1-14-21-19(13-33(24(14)34)25-7-10-26(35,11-8-25)12-9-25)23(32-16(3)31-21)30-15(2)17-5-4-6-18(20(17)27)22(28)29/h4-6,13,15,22,35H,7-12H2,1-3H3,(H,30,31,32)/t15-,25?,26?/m1/s1
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TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472573
PNG
(US10829487, Example I-52)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(C)CC1)c1cccc(c1F)C(C)(F)F
Show InChI InChI=1S/C22H23F3N4O/c1-12(14-6-5-7-16(19(14)23)22(4,24)25)26-20-15-11-29(21(3)8-9-21)18(30)10-17(15)27-13(2)28-20/h5-7,10-12H,8-9H2,1-4H3,(H,26,27,28)/t12-/m1/s1
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TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472559
PNG
(US10829487, Example I-38)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(CF)CC1)c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C22H22F4N4O/c1-12-15(5-4-6-17(12)22(24,25)26)13(2)27-20-16-10-30(21(11-23)7-8-21)19(31)9-18(16)28-14(3)29-20/h4-6,9-10,13H,7-8,11H2,1-3H3,(H,27,28,29)/t13-/m1/s1
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TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472574
PNG
(US10829487, Example I-53)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(CF)CC1)c1cccc(c1F)C(C)(F)F
Show InChI InChI=1S/C22H22F4N4O/c1-12(14-5-4-6-16(19(14)24)21(3,25)26)27-20-15-10-30(22(11-23)7-8-22)18(31)9-17(15)28-13(2)29-20/h4-6,9-10,12H,7-8,11H2,1-3H3,(H,27,28,29)/t12-/m1/s1
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TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472609
PNG
(US10829487, Example I-92)
Show SMILES C[C@@H](Nc1nc(C)nc2c(F)c(=O)n(cc12)C1(C)CC1)c1cccc(c1)C(F)(F)C1CCCO1
Show InChI InChI=1S/C25H27F3N4O2/c1-14(16-6-4-7-17(12-16)25(27,28)19-8-5-11-34-19)29-22-18-13-32(24(3)9-10-24)23(33)20(26)21(18)30-15(2)31-22/h4,6-7,12-14,19H,5,8-11H2,1-3H3,(H,29,30,31)/t14-,19?/m1/s1
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TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472623
PNG
(US10829487, Example I-106)
Show SMILES C[C@@H](Nc1ncnc2cc(=O)n(cc12)C12CC(C1)C2)c1cccc2c1CCC2(F)F
Show InChI InChI=1S/C23H22F2N4O/c1-13(15-3-2-4-18-16(15)5-6-23(18,24)25)28-21-17-11-29(22-8-14(9-22)10-22)20(30)7-19(17)26-12-27-21/h2-4,7,11-14H,5-6,8-10H2,1H3,(H,26,27,28)/t13-,14?,22?/m1/s1
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TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472633
PNG
(US10829487, Example I-116)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C12CCN(CC1)CC2)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H26F3N5O/c1-15(17-4-3-5-18(12-17)24(25,26)27)28-22-19-14-32(21(33)13-20(19)29-16(2)30-22)23-6-9-31(10-7-23)11-8-23/h3-5,12-15H,6-11H2,1-2H3,(H,28,29,30)/t15-/m1/s1
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TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472621
PNG
(US10829487, Example I-104)
Show SMILES C[C@@H](Nc1ncnc2cc(=O)n(cc12)C1(C)CC1)c1cccc2c1CCC2(F)F
Show InChI InChI=1S/C22H22F2N4O/c1-13(14-4-3-5-17-15(14)6-7-22(17,23)24)27-20-16-11-28(21(2)8-9-21)19(29)10-18(16)25-12-26-20/h3-5,10-13H,6-9H2,1-2H3,(H,25,26,27)/t13-/m1/s1
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TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472523
PNG
(US10829487, Example I-3)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(CC1)C(F)F)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C21H19F5N4O/c1-10(12-4-3-5-13(17(12)22)18(23)24)27-19-14-9-30(21(6-7-21)20(25)26)16(31)8-15(14)28-11(2)29-19/h3-5,8-10,18,20H,6-7H2,1-2H3,(H,27,28,29)/t10-/m1/s1
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TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472575
PNG
(US10829487, Example I-54)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(CC1)C(F)F)c1cccc(c1F)C(C)(F)F
Show InChI InChI=1S/C22H21F5N4O/c1-11(13-5-4-6-15(18(13)23)21(3,26)27)28-19-14-10-31(22(7-8-22)20(24)25)17(32)9-16(14)29-12(2)30-19/h4-6,9-11,20H,7-8H2,1-3H3,(H,28,29,30)/t11-/m1/s1
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TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472620
PNG
(US10829487, Example I-103)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(CC1)C(F)F)c1cccc2c(F)coc12
Show InChI InChI=1S/C22H19F3N4O2/c1-11(13-4-3-5-14-16(23)10-31-19(13)14)26-20-15-9-29(22(6-7-22)21(24)25)18(30)8-17(15)27-12(2)28-20/h3-5,8-11,21H,6-7H2,1-2H3,(H,26,27,28)/t11-/m1/s1
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TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472648
PNG
(US10829487, Example I-155)
Show SMILES C[C@@H](Nc1nc(C)nc2c(C)c(=O)n(cc12)C1(C)CC1)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C22H23F3N4O/c1-11-18-16(10-29(21(11)30)22(4)8-9-22)20(28-13(3)27-18)26-12(2)14-6-5-7-15(17(14)23)19(24)25/h5-7,10,12,19H,8-9H2,1-4H3,(H,26,27,28)/t12-/m1/s1
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TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472599
PNG
(US10829487, Example I-82)
Show SMILES C[C@@H](Nc1nc(C)nc2c(F)c(=O)n(cc12)C1(CC1)C(F)F)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C21H18F6N4O/c1-9(11-4-3-5-12(14(11)22)17(24)25)28-18-13-8-31(21(6-7-21)20(26)27)19(32)15(23)16(13)29-10(2)30-18/h3-5,8-9,17,20H,6-7H2,1-2H3,(H,28,29,30)/t9-/m1/s1
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TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472538
PNG
(US10829487, Example I-18)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1CCOCC1)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C22H23F3N4O2/c1-12(15-4-3-5-16(20(15)23)21(24)25)26-22-17-11-29(14-6-8-31-9-7-14)19(30)10-18(17)27-13(2)28-22/h3-5,10-12,14,21H,6-9H2,1-2H3,(H,26,27,28)/t12-/m1/s1
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TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472612
PNG
(US10829487, Example I-95)
Show SMILES C[C@@H](Nc1nc(C)nc2c(F)c(=O)n(cc12)C1(CC1)C(F)F)c1cccc(c1F)C(F)(F)[C@@H]1CCCO1
Show InChI InChI=1S/C25H24F6N4O2/c1-12(14-5-3-6-16(18(14)26)25(30,31)17-7-4-10-37-17)32-21-15-11-35(24(8-9-24)23(28)29)22(36)19(27)20(15)33-13(2)34-21/h3,5-6,11-12,17,23H,4,7-10H2,1-2H3,(H,32,33,34)/t12-,17+/m1/s1
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TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472636
PNG
(US10829487, Example I-119)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)[C@@]1(CCOC1)C(F)(F)F)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C22H20F6N4O2/c1-11(13-4-3-5-14(18(13)23)19(24)25)29-20-15-9-32(17(33)8-16(15)30-12(2)31-20)21(22(26,27)28)6-7-34-10-21/h3-5,8-9,11,19H,6-7,10H2,1-2H3,(H,29,30,31)/t11-,21-/m1/s1
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TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472638
PNG
(US10829487, Example I-121)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C12CCC(F)(CC1)CC2)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C25H26F4N4O/c1-14(16-4-3-5-17(21(16)26)22(27)28)30-23-18-13-33(20(34)12-19(18)31-15(2)32-23)25-9-6-24(29,7-10-25)8-11-25/h3-5,12-14,22H,6-11H2,1-2H3,(H,30,31,32)/t14-,24?,25?/m1/s1
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TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472671
PNG
(US10829487, Example I-178)
Show SMILES C[C@@H](Nc1ncnc2c(C)c(=O)n(cc12)C12CC(F)(C1)C2)c1cccc(c1F)C(F)(F)C(C)(C)O
Show InChI InChI=1S/C25H26F4N4O2/c1-13-19-16(8-33(21(13)34)24-9-23(27,10-24)11-24)20(31-12-30-19)32-14(2)15-6-5-7-17(18(15)26)25(28,29)22(3,4)35/h5-8,12,14,35H,9-11H2,1-4H3,(H,30,31,32)/t14-,23?,24?/m1/s1
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TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472643
PNG
(US10829487, Example I-126)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(C)CCOC1)c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C23H25F3N4O2/c1-13-16(6-5-7-18(13)23(24,25)26)14(2)27-21-17-11-30(22(4)8-9-32-12-22)20(31)10-19(17)28-15(3)29-21/h5-7,10-11,14H,8-9,12H2,1-4H3,(H,27,28,29)/t14-,22?/m1/s1
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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472521
PNG
(US10829487, Example I-1)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(C)CC1)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C21H21F3N4O/c1-11(13-5-4-6-14(18(13)22)19(23)24)25-20-15-10-28(21(3)7-8-21)17(29)9-16(15)26-12(2)27-20/h4-6,9-11,19H,7-8H2,1-3H3,(H,25,26,27)/t11-/m1/s1
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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472531
PNG
(US10829487, Example I-11)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(C)CCC1)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C22H23F3N4O/c1-12(14-6-4-7-15(19(14)23)20(24)25)26-21-16-11-29(22(3)8-5-9-22)18(30)10-17(16)27-13(2)28-21/h4,6-7,10-12,20H,5,8-9H2,1-3H3,(H,26,27,28)/t12-/m1/s1
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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472537
PNG
(US10829487, Example I-17)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C12CC(C1)(C2)N1CCOCC1)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C26H28F3N5O2/c1-15(17-4-3-5-18(22(17)27)23(28)29)30-24-19-11-34(21(35)10-20(19)31-16(2)32-24)26-12-25(13-26,14-26)33-6-8-36-9-7-33/h3-5,10-11,15,23H,6-9,12-14H2,1-2H3,(H,30,31,32)/t15-,25?,26?/m1/s1
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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472564
PNG
(US10829487, Example I-43)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)[C@H]1C[C@H](O)C1)c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C22H23F3N4O2/c1-11-16(5-4-6-18(11)22(23,24)25)12(2)26-21-17-10-29(14-7-15(30)8-14)20(31)9-19(17)27-13(3)28-21/h4-6,9-10,12,14-15,30H,7-8H2,1-3H3,(H,26,27,28)/t12-,14-,15-/m1/s1
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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472611
PNG
(US10829487, Example I-94)
Show SMILES C[C@@H](Nc1nc(C)nc2c(F)c(=O)n(cc12)C1(C)CC1)c1cccc(c1F)C(F)(F)[C@@H]1CCCO1
Show InChI InChI=1S/C25H26F4N4O2/c1-13(15-6-4-7-17(19(15)26)25(28,29)18-8-5-11-35-18)30-22-16-12-33(24(3)9-10-24)23(34)20(27)21(16)31-14(2)32-22/h4,6-7,12-13,18H,5,8-11H2,1-3H3,(H,30,31,32)/t13-,18+/m1/s1
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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472650
PNG
(US10829487, Example I-157)
Show SMILES C[C@@H](Nc1nc(C)nc2c(C)c(=O)n(cc12)C1(C)CC1)c1cccc(C(F)F)c1C
Show InChI InChI=1S/C23H26F2N4O/c1-12-16(7-6-8-17(12)20(24)25)14(3)26-21-18-11-29(23(5)9-10-23)22(30)13(2)19(18)27-15(4)28-21/h6-8,11,14,20H,9-10H2,1-5H3,(H,26,27,28)/t14-/m1/s1
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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472558
PNG
(US10829487, Example I-37)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(C)CC1)c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C22H23F3N4O/c1-12-15(6-5-7-17(12)22(23,24)25)13(2)26-20-16-11-29(21(4)8-9-21)19(30)10-18(16)27-14(3)28-20/h5-7,10-11,13H,8-9H2,1-4H3,(H,26,27,28)/t13-/m1/s1
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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472598
PNG
(US10829487, Example I-81)
Show SMILES C[C@@H](Nc1nc(C)nc2c(F)c(=O)n(cc12)C1(CF)CC1)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C21H19F5N4O/c1-10(12-4-3-5-13(15(12)23)18(25)26)27-19-14-8-30(21(9-22)6-7-21)20(31)16(24)17(14)28-11(2)29-19/h3-5,8,10,18H,6-7,9H2,1-2H3,(H,27,28,29)/t10-/m1/s1
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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472595
PNG
(US10829487, Example I-77)
Show SMILES C[C@@H](Nc1ncnc2cc(=O)n(cc12)C1(CF)CC1)c1cccc(c1F)C(C)(F)F
Show InChI InChI=1S/C21H20F4N4O/c1-12(13-4-3-5-15(18(13)23)20(2,24)25)28-19-14-9-29(21(10-22)6-7-21)17(30)8-16(14)26-11-27-19/h3-5,8-9,11-12H,6-7,10H2,1-2H3,(H,26,27,28)/t12-/m1/s1
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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472626
PNG
(US10829487, Example I-109)
Show SMILES C[C@@H](Nc1ncnc2cc(=O)n(cc12)C12CCC(CC1)C2)c1cccc2C(=O)CCc12
Show InChI InChI=1S/C25H26N4O2/c1-15(17-3-2-4-19-18(17)5-6-22(19)30)28-24-20-13-29(23(31)11-21(20)26-14-27-24)25-9-7-16(12-25)8-10-25/h2-4,11,13-16H,5-10,12H2,1H3,(H,26,27,28)/t15-,16?,25?/m1/s1
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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472664
PNG
(US10829487, Example I-171)
Show SMILES C[C@@H](Nc1ncnc2c(C)c(=O)n(cc12)C12CCC(F)(CC1)CC2)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C25H26F4N4O/c1-14-20-18(12-33(23(14)34)25-9-6-24(29,7-10-25)8-11-25)22(31-13-30-20)32-15(2)16-4-3-5-17(19(16)26)21(27)28/h3-5,12-13,15,21H,6-11H2,1-2H3,(H,30,31,32)/t15-,24?,25?/m1/s1
PDB

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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472588
PNG
(US10829487, Example I-69)
Show SMILES C[C@@H](Nc1ncnc2cc(=O)n(cc12)[C@H]1C[C@H](F)C1)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C20H18F4N4O/c1-10(13-3-2-4-14(18(13)22)19(23)24)27-20-15-8-28(12-5-11(21)6-12)17(29)7-16(15)25-9-26-20/h2-4,7-12,19H,5-6H2,1H3,(H,25,26,27)/t10-,11-,12-/m1/s1
PDB

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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472526
PNG
(US10829487, Example I-6)
Show SMILES COCC1(CC1)n1cc2c(N[C@H](C)c3cccc(C(F)F)c3F)nc(C)nc2cc1=O
Show InChI InChI=1S/C22H23F3N4O2/c1-12(14-5-4-6-15(19(14)23)20(24)25)26-21-16-10-29(22(7-8-22)11-31-3)18(30)9-17(16)27-13(2)28-21/h4-6,9-10,12,20H,7-8,11H2,1-3H3,(H,26,27,28)/t12-/m1/s1
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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472542
PNG
(US10829487, Example I-22)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1CCC1)c1cccc(C(F)F)c1C
Show InChI InChI=1S/C22H24F2N4O/c1-12-16(8-5-9-17(12)21(23)24)13(2)25-22-18-11-28(15-6-4-7-15)20(29)10-19(18)26-14(3)27-22/h5,8-11,13,15,21H,4,6-7H2,1-3H3,(H,25,26,27)/t13-/m1/s1
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n/an/a 6n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472603
PNG
(US10829487, Example I-86)
Show SMILES C[C@@H](Nc1nc(C)nc2c(F)c(=O)n(cc12)C1(C)CC1)c1cccc(c1F)C(C)(F)F
Show InChI InChI=1S/C22H22F4N4O/c1-11(13-6-5-7-15(16(13)23)22(4,25)26)27-19-14-10-30(21(3)8-9-21)20(31)17(24)18(14)28-12(2)29-19/h5-7,10-11H,8-9H2,1-4H3,(H,27,28,29)/t11-/m1/s1
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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472570
PNG
(US10829487, Example I-49)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1CCOCC1)c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C23H25F3N4O2/c1-13-17(5-4-6-19(13)23(24,25)26)14(2)27-22-18-12-30(16-7-9-32-10-8-16)21(31)11-20(18)28-15(3)29-22/h4-6,11-12,14,16H,7-10H2,1-3H3,(H,27,28,29)/t14-/m1/s1
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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472637
PNG
(US10829487, Example I-120)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C12CCC(CC1)CC2)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C25H27F3N4O/c1-14(17-4-3-5-18(22(17)26)23(27)28)29-24-19-13-32(21(33)12-20(19)30-15(2)31-24)25-9-6-16(7-10-25)8-11-25/h3-5,12-14,16,23H,6-11H2,1-2H3,(H,29,30,31)/t14-,16?,25?/m1/s1
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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472584
PNG
(US10829487, Example I-63)
Show SMILES C[C@@H](Nc1ncnc2cc(=O)n(cc12)C1(CF)CC1)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C20H18F4N4O/c1-11(12-3-2-4-13(17(12)22)18(23)24)27-19-14-8-28(20(9-21)5-6-20)16(29)7-15(14)25-10-26-19/h2-4,7-8,10-11,18H,5-6,9H2,1H3,(H,25,26,27)/t11-/m1/s1
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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472655
PNG
(US10829487, Example I-162)
Show SMILES C[C@@H](Nc1ncnc2c(C)c(=O)n(cc12)C1(CF)CC1)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C21H20F4N4O/c1-11-17-15(8-29(20(11)30)21(9-22)6-7-21)19(27-10-26-17)28-12(2)13-4-3-5-14(16(13)23)18(24)25/h3-5,8,10,12,18H,6-7,9H2,1-2H3,(H,26,27,28)/t12-/m1/s1
PDB

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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472583
PNG
(US10829487, Example I-62)
Show SMILES C[C@@H](Nc1ncnc2cc(=O)n(cc12)C1(C)CC1)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C20H19F3N4O/c1-11(12-4-3-5-13(17(12)21)18(22)23)26-19-14-9-27(20(2)6-7-20)16(28)8-15(14)24-10-25-19/h3-5,8-11,18H,6-7H2,1-2H3,(H,24,25,26)/t11-/m1/s1
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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472613
PNG
(US10829487, Example I-96)
Show SMILES C[C@@H](Nc1ncnc2c(F)c(=O)n(cc12)C1(CC1)C(F)F)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C20H16F6N4O/c1-9(10-3-2-4-11(13(10)21)16(23)24)29-17-12-7-30(20(5-6-20)19(25)26)18(31)14(22)15(12)27-8-28-17/h2-4,7-9,16,19H,5-6H2,1H3,(H,27,28,29)/t9-/m1/s1
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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472590
PNG
(US10829487, Example I-71 | US10829487, Example I-7...)
Show SMILES C[C@@H](Nc1ncnc2cc(=O)n(cc12)C12CC(F)(C1)C2)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C21H18F4N4O/c1-11(12-3-2-4-13(17(12)22)18(23)24)28-19-14-6-29(21-7-20(25,8-21)9-21)16(30)5-15(14)26-10-27-19/h2-6,10-11,18H,7-9H2,1H3,(H,26,27,28)/t11-,20?,21?/m1/s1
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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472616
PNG
(US10829487, Example I-99)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(CC1)C(F)F)c1cccc(c1)C(C)(F)F
Show InChI InChI=1S/C22H22F4N4O/c1-12(14-5-4-6-15(9-14)21(3,25)26)27-19-16-11-30(22(7-8-22)20(23)24)18(31)10-17(16)28-13(2)29-19/h4-6,9-12,20H,7-8H2,1-3H3,(H,27,28,29)/t12-/m1/s1
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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472532
PNG
(US10829487, Example I-12)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)[C@H]1C[C@H](F)C1)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C21H20F4N4O/c1-10(14-4-3-5-15(19(14)23)20(24)25)26-21-16-9-29(13-6-12(22)7-13)18(30)8-17(16)27-11(2)28-21/h3-5,8-10,12-13,20H,6-7H2,1-2H3,(H,26,27,28)/t10-,12-,13-/m1/s1
PDB

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n/an/a 7n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472589
PNG
(US10829487, Example I-70)
Show SMILES C[C@@H](Nc1ncnc2cc(=O)n(cc12)C12CC(C1)C2)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C21H19F3N4O/c1-11(13-3-2-4-14(18(13)22)19(23)24)27-20-15-9-28(21-6-12(7-21)8-21)17(29)5-16(15)25-10-26-20/h2-5,9-12,19H,6-8H2,1H3,(H,25,26,27)/t11-,12?,21?/m1/s1
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TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472594
PNG
(US10829487, Example I-76)
Show SMILES C[C@@H](Nc1ncnc2cc(=O)n(cc12)C1(C)CC1)c1cccc(c1F)C(C)(F)F
Show InChI InChI=1S/C21H21F3N4O/c1-12(13-5-4-6-15(18(13)22)21(3,23)24)27-19-14-10-28(20(2)7-8-20)17(29)9-16(14)25-11-26-19/h4-6,9-12H,7-8H2,1-3H3,(H,25,26,27)/t12-/m1/s1
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n/an/a 7n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472585
PNG
(US10829487, Example I-64)
Show SMILES C[C@@H](Nc1ncnc2cc(=O)n(cc12)C1(CC1)C(F)F)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C20H17F5N4O/c1-10(11-3-2-4-12(16(11)21)17(22)23)28-18-13-8-29(20(5-6-20)19(24)25)15(30)7-14(13)26-9-27-18/h2-4,7-10,17,19H,5-6H2,1H3,(H,26,27,28)/t10-/m1/s1
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n/an/a 8n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472601
PNG
(US10829487, Example I-84)
Show SMILES C[C@@H](Nc1nc(C)nc2c(F)c(=O)n(cc12)[C@H]1C[C@H](F)C1)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C21H19F5N4O/c1-9(13-4-3-5-14(16(13)23)19(25)26)27-20-15-8-30(12-6-11(22)7-12)21(31)17(24)18(15)28-10(2)29-20/h3-5,8-9,11-12,19H,6-7H2,1-2H3,(H,27,28,29)/t9-,11-,12-/m1/s1
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n/an/a 8n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472524
PNG
(US10829487, Example I-4)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(CC1)C(F)(F)F)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C21H18F6N4O/c1-10(12-4-3-5-13(17(12)22)18(23)24)28-19-14-9-31(20(6-7-20)21(25,26)27)16(32)8-15(14)29-11(2)30-19/h3-5,8-10,18H,6-7H2,1-2H3,(H,28,29,30)/t10-/m1/s1
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n/an/a 8n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472535
PNG
(US10829487, Example I-15)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C12CC(C1)C2)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C22H21F3N4O/c1-11(14-4-3-5-15(19(14)23)20(24)25)26-21-16-10-29(22-7-13(8-22)9-22)18(30)6-17(16)27-12(2)28-21/h3-6,10-11,13,20H,7-9H2,1-2H3,(H,26,27,28)/t11-,13?,22?/m1/s1
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n/an/a 8n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472527
PNG
(US10829487, Example I-7)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(CC1)c1ccncc1)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C25H22F3N5O/c1-14(17-4-3-5-18(22(17)26)23(27)28)30-24-19-13-33(21(34)12-20(19)31-15(2)32-24)25(8-9-25)16-6-10-29-11-7-16/h3-7,10-14,23H,8-9H2,1-2H3,(H,30,31,32)/t14-/m1/s1
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n/an/a 8n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472615
PNG
(US10829487, Example I-98)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(CC1)C(F)F)c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C21H18F6N4O/c1-10(12-4-3-5-14(17(12)22)21(25,26)27)28-18-13-9-31(20(6-7-20)19(23)24)16(32)8-15(13)29-11(2)30-18/h3-5,8-10,19H,6-7H2,1-2H3,(H,28,29,30)/t10-/m1/s1
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n/an/a 8n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472597
PNG
(US10829487, Example I-80)
Show SMILES C[C@@H](Nc1nc(C)nc2c(F)c(=O)n(cc12)C1(C)CC1)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C21H20F4N4O/c1-10(12-5-4-6-13(15(12)22)18(24)25)26-19-14-9-29(21(3)7-8-21)20(30)16(23)17(14)27-11(2)28-19/h4-6,9-10,18H,7-8H2,1-3H3,(H,26,27,28)/t10-/m1/s1
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n/an/a 9n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472555
PNG
(US10829487, Example I-35)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1CCOCC1)c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C22H22F4N4O2/c1-12(15-4-3-5-17(20(15)23)22(24,25)26)27-21-16-11-30(14-6-8-32-9-7-14)19(31)10-18(16)28-13(2)29-21/h3-5,10-12,14H,6-9H2,1-2H3,(H,27,28,29)/t12-/m1/s1
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n/an/a 9n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472634
PNG
(US10829487, Example I-117)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(CCOC1)C(F)(F)F)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C22H20F6N4O2/c1-11(13-4-3-5-14(18(13)23)19(24)25)29-20-15-9-32(17(33)8-16(15)30-12(2)31-20)21(22(26,27)28)6-7-34-10-21/h3-5,8-9,11,19H,6-7,10H2,1-2H3,(H,29,30,31)/t11-,21?/m1/s1
PDB

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n/an/a 9n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472667
PNG
(US10829487, Example I-174)
Show SMILES C[C@@H](Nc1ncnc2c(C)c(=O)n(cc12)C1(C)CC1)c1cccc(c1F)C(C)(F)F
Show InChI InChI=1S/C22H23F3N4O/c1-12-18-15(10-29(20(12)30)21(3)8-9-21)19(27-11-26-18)28-13(2)14-6-5-7-16(17(14)23)22(4,24)25/h5-7,10-11,13H,8-9H2,1-4H3,(H,26,27,28)/t13-/m1/s1
PDB

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n/an/a 9n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472561
PNG
(US10829487, Example I-40)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)[C@@H]1[C@H]2COC[C@@H]12)c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C23H23F3N4O2/c1-11-14(5-4-6-18(11)23(24,25)26)12(2)27-22-15-8-30(21-16-9-32-10-17(16)21)20(31)7-19(15)28-13(3)29-22/h4-8,12,16-17,21H,9-10H2,1-3H3,(H,27,28,29)/t12-,16-,17+,21+/m1/s1
PDB

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n/an/a 9n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472628
PNG
(US10829487, Example I-111)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(C)CCOC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H23F3N4O2/c1-13(15-5-4-6-16(9-15)22(23,24)25)26-20-17-11-29(21(3)7-8-31-12-21)19(30)10-18(17)27-14(2)28-20/h4-6,9-11,13H,7-8,12H2,1-3H3,(H,26,27,28)/t13-,21?/m1/s1
PDB

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n/an/a 9n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472563
PNG
(US10829487, Example I-42)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(C)CCC1)c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C23H25F3N4O/c1-13-16(7-5-8-18(13)23(24,25)26)14(2)27-21-17-12-30(22(4)9-6-10-22)20(31)11-19(17)28-15(3)29-21/h5,7-8,11-12,14H,6,9-10H2,1-4H3,(H,27,28,29)/t14-/m1/s1
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n/an/a 9n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472602
PNG
(US10829487, Example I-85)
Show SMILES C[C@@H](Nc1nc(C)nc2c(F)c(=O)n(cc12)[C@@]1(CCOC1)C(F)(F)F)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C22H19F7N4O2/c1-10(12-4-3-5-13(15(12)23)18(25)26)30-19-14-8-33(21(22(27,28)29)6-7-35-9-21)20(34)16(24)17(14)31-11(2)32-19/h3-5,8,10,18H,6-7,9H2,1-2H3,(H,30,31,32)/t10-,21-/m1/s1
PDB

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n/an/a 9n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472590
PNG
(US10829487, Example I-71 | US10829487, Example I-7...)
Show SMILES C[C@@H](Nc1ncnc2cc(=O)n(cc12)C12CC(F)(C1)C2)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C21H18F4N4O/c1-11(12-3-2-4-13(17(12)22)18(23)24)28-19-14-6-29(21-7-20(25,8-21)9-21)16(30)5-15(14)26-10-27-19/h2-6,10-11,18H,7-9H2,1H3,(H,26,27,28)/t11-,20?,21?/m1/s1
PDB

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TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472661
PNG
(US10829487, Example I-168)
Show SMILES C[C@@H](Nc1ncnc2c(C)c(=O)n(cc12)[C@H]1C[C@H](F)C1)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C21H20F4N4O/c1-10-18-16(8-29(21(10)30)13-6-12(22)7-13)20(27-9-26-18)28-11(2)14-4-3-5-15(17(14)23)19(24)25/h3-5,8-9,11-13,19H,6-7H2,1-2H3,(H,26,27,28)/t11-,12-,13-/m1/s1
PDB

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n/an/a 9n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472571
PNG
(US10829487, Example I-50)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(C)CC1)c1cccc(c1)C(C)(F)F
Show InChI InChI=1S/C22H24F2N4O/c1-13(15-6-5-7-16(10-15)22(4,23)24)25-20-17-12-28(21(3)8-9-21)19(29)11-18(17)26-14(2)27-20/h5-7,10-13H,8-9H2,1-4H3,(H,25,26,27)/t13-/m1/s1
PDB

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n/an/a 9n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472669
PNG
(US10829487, Example I-176)
Show SMILES C[C@@H](Nc1ncnc2c(C)c(=O)n(cc12)C12CC(F)(C1)C2)c1cccc(c1F)C(C)(F)F
Show InChI InChI=1S/C23H22F4N4O/c1-12-18-15(7-31(20(12)32)23-8-22(27,9-23)10-23)19(29-11-28-18)30-13(2)14-5-4-6-16(17(14)24)21(3,25)26/h4-7,11,13H,8-10H2,1-3H3,(H,28,29,30)/t13-,22?,23?/m1/s1
PDB

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n/an/a 10n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472544
PNG
(US10829487, Example I-24)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C12CCC(CC1)(C2)C(=O)N(C)C)c1cccc(C(F)F)c1C
Show InChI InChI=1S/C28H33F2N5O2/c1-16-19(7-6-8-20(16)24(29)30)17(2)31-25-21-14-35(23(36)13-22(21)32-18(3)33-25)28-11-9-27(15-28,10-12-28)26(37)34(4)5/h6-8,13-14,17,24H,9-12,15H2,1-5H3,(H,31,32,33)/t17-,27?,28?/m1/s1
PDB

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n/an/a 10n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472586
PNG
(US10829487, Example I-65)
Show SMILES C[C@@H](Nc1ncnc2cc(=O)n(cc12)C1(CC1)C(F)(F)F)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C20H16F6N4O/c1-10(11-3-2-4-12(16(11)21)17(22)23)29-18-13-8-30(19(5-6-19)20(24,25)26)15(31)7-14(13)27-9-28-18/h2-4,7-10,17H,5-6H2,1H3,(H,27,28,29)/t10-/m1/s1
PDB

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n/an/a 10n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472632
PNG
(US10829487, Example I-115)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C12CCC(CC1)C2)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H25F3N4O/c1-14(17-4-3-5-18(10-17)24(25,26)27)28-22-19-13-31(23-8-6-16(12-23)7-9-23)21(32)11-20(19)29-15(2)30-22/h3-5,10-11,13-14,16H,6-9,12H2,1-2H3,(H,28,29,30)/t14-,16?,23?/m1/s1
PDB

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n/an/a 10n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472533
PNG
(US10829487, Example I-13)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1CC(F)(F)C1)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C21H19F5N4O/c1-10(13-4-3-5-14(18(13)22)19(23)24)27-20-15-9-30(12-7-21(25,26)8-12)17(31)6-16(15)28-11(2)29-20/h3-6,9-10,12,19H,7-8H2,1-2H3,(H,27,28,29)/t10-/m1/s1
PDB

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n/an/a 11n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472566
PNG
(US10829487, Example I-45)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1C[C@H](O)C1)c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C22H23F3N4O2/c1-11-16(5-4-6-18(11)22(23,24)25)12(2)26-21-17-10-29(14-7-15(30)8-14)20(31)9-19(17)27-13(3)28-21/h4-6,9-10,12,14-15,30H,7-8H2,1-3H3,(H,26,27,28)/t12-,14?,15-/m1/s1
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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472551
PNG
(US10829487, Example I-31)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1CCOCC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H23F3N4O2/c1-13(15-4-3-5-16(10-15)22(23,24)25)26-21-18-12-29(17-6-8-31-9-7-17)20(30)11-19(18)27-14(2)28-21/h3-5,10-13,17H,6-9H2,1-2H3,(H,26,27,28)/t13-/m1/s1
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n/an/a 11n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472591
PNG
(US10829487, Example I-72)
Show SMILES C[C@@H](Nc1ncnc2cc(=O)n(cc12)C1(CCOC1)C(F)(F)F)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C21H18F6N4O2/c1-11(12-3-2-4-13(17(12)22)18(23)24)30-19-14-8-31(16(32)7-15(14)28-10-29-19)20(21(25,26)27)5-6-33-9-20/h2-4,7-8,10-11,18H,5-6,9H2,1H3,(H,28,29,30)/t11-,20?/m1/s1
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n/an/a 11n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472530
PNG
(US10829487, Example I-10)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)[C@H](C)C(F)(F)F)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C20H18F6N4O/c1-9(12-5-4-6-13(17(12)21)18(22)23)27-19-14-8-30(10(2)20(24,25)26)16(31)7-15(14)28-11(3)29-19/h4-10,18H,1-3H3,(H,27,28,29)/t9-,10-/m1/s1
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n/an/a 11n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472536
PNG
(US10829487, Example I-16)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C12CC(F)(C1)C2)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C22H20F4N4O/c1-11(13-4-3-5-14(18(13)23)19(24)25)27-20-15-7-30(22-8-21(26,9-22)10-22)17(31)6-16(15)28-12(2)29-20/h3-7,11,19H,8-10H2,1-2H3,(H,27,28,29)/t11-,21?,22?/m1/s1
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n/an/a 12n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472525
PNG
(US10829487, Example I-5)
Show SMILES CCC1(CC1)n1cc2c(N[C@H](C)c3cccc(C(F)F)c3F)nc(C)nc2cc1=O
Show InChI InChI=1S/C22H23F3N4O/c1-4-22(8-9-22)29-11-16-17(10-18(29)30)27-13(3)28-21(16)26-12(2)14-6-5-7-15(19(14)23)20(24)25/h5-7,10-12,20H,4,8-9H2,1-3H3,(H,26,27,28)/t12-/m1/s1
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n/an/a 12n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472552
PNG
(US10829487, Example I-32)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)[C@@H]1[C@H]2COC[C@@H]12)c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C22H20F4N4O2/c1-10(12-4-3-5-16(19(12)23)22(24,25)26)27-21-13-7-30(20-14-8-32-9-15(14)20)18(31)6-17(13)28-11(2)29-21/h3-7,10,14-15,20H,8-9H2,1-2H3,(H,27,28,29)/t10-,14-,15+,20+/m1/s1
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n/an/a 12n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472565
PNG
(US10829487, Example I-44)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)[C@@H]1C[C@H](O)C1)c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C22H23F3N4O2/c1-11-16(5-4-6-18(11)22(23,24)25)12(2)26-21-17-10-29(14-7-15(30)8-14)20(31)9-19(17)27-13(3)28-21/h4-6,9-10,12,14-15,30H,7-8H2,1-3H3,(H,26,27,28)/t12-,14-,15+/m1/s1
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n/an/a 12n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472662
PNG
(US10829487, Example I-169)
Show SMILES C[C@@H](Nc1ncnc2c(C)c(=O)n(cc12)C12CC(C1)C2)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C22H21F3N4O/c1-11-18-16(9-29(21(11)30)22-6-13(7-22)8-22)20(27-10-26-18)28-12(2)14-4-3-5-15(17(14)23)19(24)25/h3-5,9-10,12-13,19H,6-8H2,1-2H3,(H,26,27,28)/t12-,13?,22?/m1/s1
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n/an/a 12n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472663
PNG
(US10829487, Example I-170)
Show SMILES C[C@@H](Nc1ncnc2c(C)c(=O)n(cc12)C12CC(F)(C1)C2)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C22H20F4N4O/c1-11-17-15(6-30(20(11)31)22-7-21(26,8-22)9-22)19(28-10-27-17)29-12(2)13-4-3-5-14(16(13)23)18(24)25/h3-6,10,12,18H,7-9H2,1-2H3,(H,27,28,29)/t12-,21?,22?/m1/s1
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n/an/a 12n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472654
PNG
(US10829487, Example I-161)
Show SMILES C[C@@H](Nc1ncnc2c(C)c(=O)n(cc12)C1(C)CC1)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C21H21F3N4O/c1-11-17-15(9-28(20(11)29)21(3)7-8-21)19(26-10-25-17)27-12(2)13-5-4-6-14(16(13)22)18(23)24/h4-6,9-10,12,18H,7-8H2,1-3H3,(H,25,26,27)/t12-/m1/s1
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n/an/a 12n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472657
PNG
(US10829487, Example I-164)
Show SMILES C[C@@H](Nc1ncnc2c(C)c(=O)n(cc12)C1(CC1)C(F)(F)F)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C21H18F6N4O/c1-10-16-14(8-31(19(10)32)20(6-7-20)21(25,26)27)18(29-9-28-16)30-11(2)12-4-3-5-13(15(12)22)17(23)24/h3-5,8-9,11,17H,6-7H2,1-2H3,(H,28,29,30)/t11-/m1/s1
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n/an/a 13n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472576
PNG
(US10829487, Example I-55)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(CC1)C(F)(F)F)c1cccc(c1F)C(C)(F)F
Show InChI InChI=1S/C22H20F6N4O/c1-11(13-5-4-6-15(18(13)23)20(3,24)25)29-19-14-10-32(21(7-8-21)22(26,27)28)17(33)9-16(14)30-12(2)31-19/h4-6,9-11H,7-8H2,1-3H3,(H,29,30,31)/t11-/m1/s1
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n/an/a 13n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472629
PNG
(US10829487, Example I-112)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(C)CCOCC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H25F3N4O2/c1-14(16-5-4-6-17(11-16)23(24,25)26)27-21-18-13-30(22(3)7-9-32-10-8-22)20(31)12-19(18)28-15(2)29-21/h4-6,11-14H,7-10H2,1-3H3,(H,27,28,29)/t14-/m1/s1
PDB

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n/an/a 13n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472545
PNG
(US10829487, Example I-25)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(C)CC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H21F3N4O/c1-12(14-5-4-6-15(9-14)21(22,23)24)25-19-16-11-28(20(3)7-8-20)18(29)10-17(16)26-13(2)27-19/h4-6,9-12H,7-8H2,1-3H3,(H,25,26,27)/t12-/m1/s1
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n/an/a 13n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472668
PNG
(US10829487, Example I-175)
Show SMILES C[C@@H](Nc1ncnc2c(C)c(=O)n(cc12)C1(CF)CC1)c1cccc(c1F)C(C)(F)F
Show InChI InChI=1S/C22H22F4N4O/c1-12-18-15(9-30(20(12)31)22(10-23)7-8-22)19(28-11-27-18)29-13(2)14-5-4-6-16(17(14)24)21(3,25)26/h4-6,9,11,13H,7-8,10H2,1-3H3,(H,27,28,29)/t13-/m1/s1
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n/an/a 13n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472665
PNG
(US10829487, Example I-172)
Show SMILES C[C@@H](Nc1ncnc2c(C)c(=O)n(cc12)-c1cnn(C)c1)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C21H19F3N6O/c1-11-18-16(9-30(21(11)31)13-7-27-29(3)8-13)20(26-10-25-18)28-12(2)14-5-4-6-15(17(14)22)19(23)24/h4-10,12,19H,1-3H3,(H,25,26,28)/t12-/m1/s1
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n/an/a 14n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472562
PNG
(US10829487, Example I-41)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1CCC1)c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C22H23F3N4O/c1-12-16(8-5-9-18(12)22(23,24)25)13(2)26-21-17-11-29(15-6-4-7-15)20(30)10-19(17)27-14(3)28-21/h5,8-11,13,15H,4,6-7H2,1-3H3,(H,26,27,28)/t13-/m1/s1
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n/an/a 14n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472614
PNG
(US10829487, Example I-97)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(CC1)C(F)F)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H19F5N4O/c1-11(13-4-3-5-14(8-13)21(24,25)26)27-18-15-10-30(20(6-7-20)19(22)23)17(31)9-16(15)28-12(2)29-18/h3-5,8-11,19H,6-7H2,1-2H3,(H,27,28,29)/t11-/m1/s1
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n/an/a 14n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472587
PNG
(US10829487, Example I-66)
Show SMILES C[C@@H](Nc1ncnc2cc(=O)n(cc12)C1CC11CC1)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C21H19F3N4O/c1-11(12-3-2-4-13(18(12)22)19(23)24)27-20-14-9-28(16-8-21(16)5-6-21)17(29)7-15(14)25-10-26-20/h2-4,7,9-11,16,19H,5-6,8H2,1H3,(H,25,26,27)/t11-,16?/m1/s1
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n/an/a 15n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472593
PNG
(US10829487, Example I-75)
Show SMILES C[C@@H](Nc1ncnc2cc(=O)n(cc12)C1(C)CC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H19F3N4O/c1-12(13-4-3-5-14(8-13)20(21,22)23)26-18-15-10-27(19(2)6-7-19)17(28)9-16(15)24-11-25-18/h3-5,8-12H,6-7H2,1-2H3,(H,24,25,26)/t12-/m1/s1
PDB

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n/an/a 15n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472656
PNG
(US10829487, Example I-163)
Show SMILES C[C@@H](Nc1ncnc2c(C)c(=O)n(cc12)C1(CC1)C(F)F)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C21H19F5N4O/c1-10-16-14(8-30(19(10)31)21(6-7-21)20(25)26)18(28-9-27-16)29-11(2)12-4-3-5-13(15(12)22)17(23)24/h3-5,8-9,11,17,20H,6-7H2,1-2H3,(H,27,28,29)/t11-/m1/s1
PDB

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n/an/a 15n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472577
PNG
(US10829487, Example I-56)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C12CC(F)(C1)C2)c1cccc(c1F)C(C)(F)F
Show InChI InChI=1S/C23H22F4N4O/c1-12(14-5-4-6-16(19(14)24)21(3,25)26)28-20-15-8-31(23-9-22(27,10-23)11-23)18(32)7-17(15)29-13(2)30-20/h4-8,12H,9-11H2,1-3H3,(H,28,29,30)/t12-,22?,23?/m1/s1
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n/an/a 15n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472600
PNG
(US10829487, Example I-83)
Show SMILES C[C@@H](Nc1nc(C)nc2c(F)c(=O)n(cc12)[C@H]1C[C@@H]1C(F)F)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C21H18F6N4O/c1-8(10-4-3-5-11(15(10)22)18(24)25)28-20-13-7-31(14-6-12(14)19(26)27)21(32)16(23)17(13)29-9(2)30-20/h3-5,7-8,12,14,18-19H,6H2,1-2H3,(H,28,29,30)/t8-,12+,14+/m1/s1
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n/an/a 15n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472528
PNG
(US10829487, Example I-8)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(CC1)c1ccccc1)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C26H23F3N4O/c1-15(18-9-6-10-19(23(18)27)24(28)29)30-25-20-14-33(22(34)13-21(20)31-16(2)32-25)26(11-12-26)17-7-4-3-5-8-17/h3-10,13-15,24H,11-12H2,1-2H3,(H,30,31,32)/t15-/m1/s1
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n/an/a 16n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472658
PNG
(US10829487, Example I-165)
Show SMILES C[C@@H](Nc1ncnc2c(C)c(=O)n(cc12)[C@H]1C[C@@H]1C(F)F)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C21H19F5N4O/c1-9-17-14(7-30(21(9)31)15-6-13(15)19(25)26)20(28-8-27-17)29-10(2)11-4-3-5-12(16(11)22)18(23)24/h3-5,7-8,10,13,15,18-19H,6H2,1-2H3,(H,27,28,29)/t10-,13+,15+/m1/s1
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n/an/a 17n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472624
PNG
(US10829487, Example I-107)
Show SMILES C[C@@H](Nc1ncnc2cc(=O)n(cc12)C12CC(C1)C2)c1cccc2C(=O)CCc12
Show InChI InChI=1S/C23H22N4O2/c1-13(15-3-2-4-17-16(15)5-6-20(17)28)26-22-18-11-27(23-8-14(9-23)10-23)21(29)7-19(18)24-12-25-22/h2-4,7,11-14H,5-6,8-10H2,1H3,(H,24,25,26)/t13-,14?,23?/m1/s1
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n/an/a 17n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472560
PNG
(US10829487, Example I-39)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(CC1)C(F)(F)F)c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C22H20F6N4O/c1-11-14(5-4-6-16(11)21(23,24)25)12(2)29-19-15-10-32(20(7-8-20)22(26,27)28)18(33)9-17(15)30-13(3)31-19/h4-6,9-10,12H,7-8H2,1-3H3,(H,29,30,31)/t12-/m1/s1
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n/an/a 18n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472666
PNG
(US10829487, Example I-173)
Show SMILES C[C@@H](Nc1ncnc2c(C)c(=O)n(cc12)C1(C)CC1)c1cccc(c1)C(F)F
Show InChI InChI=1S/C21H22F2N4O/c1-12-17-16(10-27(20(12)28)21(3)7-8-21)19(25-11-24-17)26-13(2)14-5-4-6-15(9-14)18(22)23/h4-6,9-11,13,18H,7-8H2,1-3H3,(H,24,25,26)/t13-/m1/s1
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n/an/a 18n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472646
PNG
(US10829487, Example I-129)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(CCOC1)C(F)(F)F)c1cccc(c1F)C(C)(F)F
Show InChI InChI=1S/C23H22F6N4O2/c1-12(14-5-4-6-16(19(14)24)21(3,25)26)30-20-15-10-33(18(34)9-17(15)31-13(2)32-20)22(23(27,28)29)7-8-35-11-22/h4-6,9-10,12H,7-8,11H2,1-3H3,(H,30,31,32)/t12-,22?/m1/s1
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n/an/a 18n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472635
PNG
(US10829487, Example I-118)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)[C@]1(CCOC1)C(F)(F)F)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C22H20F6N4O2/c1-11(13-4-3-5-14(18(13)23)19(24)25)29-20-15-9-32(17(33)8-16(15)30-12(2)31-20)21(22(26,27)28)6-7-34-10-21/h3-5,8-9,11,19H,6-7,10H2,1-2H3,(H,29,30,31)/t11-,21+/m1/s1
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n/an/a 20n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472534
PNG
(US10829487, Example I-14)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(C)CC(F)(F)C1)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C22H21F5N4O/c1-11(13-5-4-6-14(18(13)23)19(24)25)28-20-15-8-31(21(3)9-22(26,27)10-21)17(32)7-16(15)29-12(2)30-20/h4-8,11,19H,9-10H2,1-3H3,(H,28,29,30)/t11-/m1/s1
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n/an/a 21n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472644
PNG
(US10829487, Example I-127)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(CCOCC1)c1ccccc1)c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C29H29F3N4O2/c1-18-22(10-7-11-24(18)29(30,31)32)19(2)33-27-23-17-36(26(37)16-25(23)34-20(3)35-27)28(12-14-38-15-13-28)21-8-5-4-6-9-21/h4-11,16-17,19H,12-15H2,1-3H3,(H,33,34,35)/t19-/m1/s1
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n/an/a 23n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472549
PNG
(US10829487, Example I-29)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1CCCCC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H25F3N4O/c1-14(16-7-6-8-17(11-16)23(24,25)26)27-22-19-13-30(18-9-4-3-5-10-18)21(31)12-20(19)28-15(2)29-22/h6-8,11-14,18H,3-5,9-10H2,1-2H3,(H,27,28,29)/t14-/m1/s1
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n/an/a 24n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472622
PNG
(US10829487, Example I-105)
Show SMILES C[C@@H](Nc1ncnc2cc(=O)n(cc12)C1(C)CC1)c1cccc2C(=O)CCc12
Show InChI InChI=1S/C22H22N4O2/c1-13(14-4-3-5-16-15(14)6-7-19(16)27)25-21-17-11-26(22(2)8-9-22)20(28)10-18(17)23-12-24-21/h3-5,10-13H,6-9H2,1-2H3,(H,23,24,25)/t13-/m1/s1
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n/an/a 25n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472627
PNG
(US10829487, Example I-110)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C(C)(C)C)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H23F3N4O/c1-12(14-7-6-8-15(9-14)21(22,23)24)25-19-16-11-28(20(3,4)5)18(29)10-17(16)26-13(2)27-19/h6-12H,1-5H3,(H,25,26,27)/t12-/m1/s1
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n/an/a 25n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472631
PNG
(US10829487, Example I-114)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(C)CCN(C)CC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H28F3N5O/c1-15(17-6-5-7-18(12-17)24(25,26)27)28-22-19-14-32(23(3)8-10-31(4)11-9-23)21(33)13-20(19)29-16(2)30-22/h5-7,12-15H,8-11H2,1-4H3,(H,28,29,30)/t15-/m1/s1
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n/an/a 26n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472659
PNG
(US10829487, Example I-166)
Show SMILES C[C@@H](Nc1ncnc2c(C)c(=O)n(cc12)[C@@H]1C[C@H]1C(F)F)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C21H19F5N4O/c1-9-17-14(7-30(21(9)31)15-6-13(15)19(25)26)20(28-8-27-17)29-10(2)11-4-3-5-12(16(11)22)18(23)24/h3-5,7-8,10,13,15,18-19H,6H2,1-2H3,(H,27,28,29)/t10-,13-,15-/m1/s1
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n/an/a 26n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472569
PNG
(US10829487, Example I-48)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)[C@H]1C[C@](O)(C1)C(F)(F)F)c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C23H22F6N4O2/c1-11-15(5-4-6-17(11)22(24,25)26)12(2)30-20-16-10-33(14-8-21(35,9-14)23(27,28)29)19(34)7-18(16)31-13(3)32-20/h4-7,10,12,14,35H,8-9H2,1-3H3,(H,30,31,32)/t12-,14-,21-/m1/s1
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n/an/a 27n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472548
PNG
(US10829487, Example I-28)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1CCCC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H23F3N4O/c1-13(15-6-5-7-16(10-15)22(23,24)25)26-21-18-12-29(17-8-3-4-9-17)20(30)11-19(18)27-14(2)28-21/h5-7,10-13,17H,3-4,8-9H2,1-2H3,(H,26,27,28)/t13-/m1/s1
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n/an/a 27n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472617
PNG
(US10829487, Example I-100)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(CC1)C(F)F)c1cccc(CC(F)(F)F)c1
Show InChI InChI=1S/C22H21F5N4O/c1-12(15-5-3-4-14(8-15)10-22(25,26)27)28-19-16-11-31(21(6-7-21)20(23)24)18(32)9-17(16)29-13(2)30-19/h3-5,8-9,11-12,20H,6-7,10H2,1-2H3,(H,28,29,30)/t12-/m1/s1
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n/an/a 30n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472529
PNG
(US10829487, Example I-9)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(CC1)c1ccc(F)cc1)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C26H22F4N4O/c1-14(18-4-3-5-19(23(18)28)24(29)30)31-25-20-13-34(22(35)12-21(20)32-15(2)33-25)26(10-11-26)16-6-8-17(27)9-7-16/h3-9,12-14,24H,10-11H2,1-2H3,(H,31,32,33)/t14-/m1/s1
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n/an/a 30n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472567
PNG
(US10829487, Example I-46)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(C)CC(F)(F)C1)c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C23H23F5N4O/c1-12-15(6-5-7-17(12)23(26,27)28)13(2)29-20-16-9-32(21(4)10-22(24,25)11-21)19(33)8-18(16)30-14(3)31-20/h5-9,13H,10-11H2,1-4H3,(H,29,30,31)/t13-/m1/s1
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n/an/a 31n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472572
PNG
(US10829487, Example I-51)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C12CC(F)(C1)C2)c1cccc(c1)C(C)(F)F
Show InChI InChI=1S/C23H23F3N4O/c1-13(15-5-4-6-16(7-15)21(3,24)25)27-20-17-9-30(23-10-22(26,11-23)12-23)19(31)8-18(17)28-14(2)29-20/h4-9,13H,10-12H2,1-3H3,(H,27,28,29)/t13-,22?,23?/m1/s1
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n/an/a 31n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472568
PNG
(US10829487, Example I-47)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)[C@H]1C[C@@](O)(C1)C(F)(F)F)c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C23H22F6N4O2/c1-11-15(5-4-6-17(11)22(24,25)26)12(2)30-20-16-10-33(14-8-21(35,9-14)23(27,28)29)19(34)7-18(16)31-13(3)32-20/h4-7,10,12,14,35H,8-9H2,1-3H3,(H,30,31,32)/t12-,14-,21+/m1/s1
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n/an/a 33n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472660
PNG
(US10829487, Example I-167)
Show SMILES C[C@@H](Nc1ncnc2c(C)c(=O)n(cc12)C1CC11CC1)c1cccc(C(F)F)c1F
Show InChI InChI=1S/C22H21F3N4O/c1-11-18-15(9-29(21(11)30)16-8-22(16)6-7-22)20(27-10-26-18)28-12(2)13-4-3-5-14(17(13)23)19(24)25/h3-5,9-10,12,16,19H,6-8H2,1-2H3,(H,26,27,28)/t12-,16?/m1/s1
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n/an/a 36n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472546
PNG
(US10829487, Example I-26)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1CC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H19F3N4O/c1-11(13-4-3-5-14(8-13)20(21,22)23)24-19-16-10-27(15-6-7-15)18(28)9-17(16)25-12(2)26-19/h3-5,8-11,15H,6-7H2,1-2H3,(H,24,25,26)/t11-/m1/s1
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n/an/a 37n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472547
PNG
(US10829487, Example I-27)
Show SMILES CC(C)n1cc2c(N[C@H](C)c3cccc(c3)C(F)(F)F)nc(C)nc2cc1=O
Show InChI InChI=1S/C20H21F3N4O/c1-11(2)27-10-16-17(9-18(27)28)25-13(4)26-19(16)24-12(3)14-6-5-7-15(8-14)20(21,22)23/h5-12H,1-4H3,(H,24,25,26)/t12-/m1/s1
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n/an/a 38n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472553
PNG
(US10829487, Example I-33)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)[C@@H]1CCOC1)c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C21H20F4N4O2/c1-11(14-4-3-5-16(19(14)22)21(23,24)25)26-20-15-9-29(13-6-7-31-10-13)18(30)8-17(15)27-12(2)28-20/h3-5,8-9,11,13H,6-7,10H2,1-2H3,(H,26,27,28)/t11-,13-/m1/s1
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n/an/a 38n/an/an/an/an/an/a


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Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


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More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472554
PNG
(US10829487, Example I-34)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)[C@H]1CCOC1)c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C21H20F4N4O2/c1-11(14-4-3-5-16(19(14)22)21(23,24)25)26-20-15-9-29(13-6-7-31-10-13)18(30)8-17(15)27-12(2)28-20/h3-5,8-9,11,13H,6-7,10H2,1-2H3,(H,26,27,28)/t11-,13+/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 39n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472550
PNG
(US10829487, Example I-30)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1CCC(F)(F)CC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H23F5N4O/c1-13(15-4-3-5-16(10-15)23(26,27)28)29-21-18-12-32(17-6-8-22(24,25)9-7-17)20(33)11-19(18)30-14(2)31-21/h3-5,10-13,17H,6-9H2,1-2H3,(H,29,30,31)/t13-/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 39n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472630
PNG
(US10829487, Example I-113)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(C)CCCOC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H25F3N4O2/c1-14(16-6-4-7-17(10-16)23(24,25)26)27-21-18-12-30(22(3)8-5-9-32-13-22)20(31)11-19(18)28-15(2)29-21/h4,6-7,10-12,14H,5,8-9,13H2,1-3H3,(H,27,28,29)/t14-,22?/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 39n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
SOS1 and KRAS G12D


()
BDBM472557
PNG
(US10829487, Example I-36)
Show SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(CCOCC1)c1ccccc1)c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C28H26F4N4O2/c1-17(20-9-6-10-22(25(20)29)28(30,31)32)33-26-21-16-36(24(37)15-23(21)34-18(2)35-26)27(11-13-38-14-12-27)19-7-4-3-5-8-19/h3-10,15-17H,11-14H2,1-2H3,(H,33,34,35)/t17-/m1/s1
PDB

GoogleScholar
UniChem
n/an/a 40n/an/an/an/an/an/a


TBA

Assay Description
Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%