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Patent code US10829492

Compile Data Set for Download or QSAR
Found 73 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472737
PNG
((R)-2-amino-5-(2-(2,5-difluorophenyl)pyrrolidin-1-...)
Show SMILES Nc1nn2ccc(nc2c1C(=O)Nc1ccc(F)cc1)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C23H19F3N6O/c24-13-3-6-15(7-4-13)28-23(33)20-21(27)30-32-11-9-19(29-22(20)32)31-10-1-2-18(31)16-12-14(25)5-8-17(16)26/h3-9,11-12,18H,1-2,10H2,(H2,27,30)(H,28,33)/t18-/m1/s1
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n/an/a<1n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
NT-3 growth factor receptor


(Homo sapiens (Human))
BDBM472759
PNG
(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...)
Show SMILES NC(=O)c1c(N)nn2ccc(nc12)N1C[C@@H](F)C[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C17H15F3N6O/c18-8-1-2-11(20)10(5-8)12-6-9(19)7-25(12)13-3-4-26-17(23-13)14(16(22)27)15(21)24-26/h1-5,9,12H,6-7H2,(H2,21,24)(H2,22,27)/t9-,12+/m0/s1
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n/an/a<1n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472764
PNG
(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...)
Show SMILES Nc1nn2ccc(nc2c1C#N)N1C[C@@H](F)C[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C17H13F3N6/c18-9-1-2-13(20)11(5-9)14-6-10(19)8-25(14)15-3-4-26-17(23-15)12(7-21)16(22)24-26/h1-5,10,14H,6,8H2,(H2,22,24)/t10-,14+/m0/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))
BDBM472735
PNG
(2-amino-5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-...)
Show SMILES Nc1nn2ccc(nc2c1C(=O)N[C@H]1CC[C@H](O)CC1)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C23H26F2N6O2/c24-13-3-8-17(25)16(12-13)18-2-1-10-30(18)19-9-11-31-22(28-19)20(21(26)29-31)23(33)27-14-4-6-15(32)7-5-14/h3,8-9,11-12,14-15,18,32H,1-2,4-7,10H2,(H2,26,29)(H,27,33)/t14-,15-,18-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472725
PNG
(2-(2,5-difluorophenyl)-4,4-difluoropyrrolidine | ...)
Show SMILES NC(=O)c1c(N)nn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C17H16F2N6O/c18-9-3-4-11(19)10(8-9)12-2-1-6-24(12)13-5-7-25-17(22-13)14(16(21)26)15(20)23-25/h3-5,7-8,12H,1-2,6H2,(H2,20,23)(H2,21,26)/t12-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472763
PNG
((R)-2-amino-5-(2-(2,5-difluorophenyl)pyrrolidin-1-...)
Show SMILES Nc1nn2ccc(nc2c1C(=O)NOCCO)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C19H20F2N6O3/c20-11-3-4-13(21)12(10-11)14-2-1-6-26(14)15-5-7-27-18(23-15)16(17(22)24-27)19(29)25-30-9-8-28/h3-5,7,10,14,28H,1-2,6,8-9H2,(H2,22,24)(H,25,29)/t14-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472757
PNG
((R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-(1...)
Show SMILES Cn1cc(cn1)-c1c(N)nn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C20H19F2N7/c1-27-11-12(10-24-27)18-19(23)26-29-8-6-17(25-20(18)29)28-7-2-3-16(28)14-9-13(21)4-5-15(14)22/h4-6,8-11,16H,2-3,7H2,1H3,(H2,23,26)/t16-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472741
PNG
((R)-2-amino-N-(tert-butoxy)-5-(2-(2,5-difluorophen...)
Show SMILES CC(C)(C)ONC(=O)c1c(N)nn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H24F2N6O2/c1-21(2,3)31-27-20(30)17-18(24)26-29-10-8-16(25-19(17)29)28-9-4-5-15(28)13-11-12(22)6-7-14(13)23/h6-8,10-11,15H,4-5,9H2,1-3H3,(H2,24,26)(H,27,30)/t15-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472730
PNG
(5-(2,5-difluorophenyl)-pyrrolidin-3-one | US10829...)
Show SMILES NC(=O)c1c(N)nn2ccc(nc12)N1CCCC1c1cc(F)ccc1F
Show InChI InChI=1S/C17H16F2N6O/c18-9-3-4-11(19)10(8-9)12-2-1-6-24(12)13-5-7-25-17(22-13)14(16(21)26)15(20)23-25/h3-5,7-8,12H,1-2,6H2,(H2,20,23)(H2,21,26)
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472752
PNG
(US10829492, Example 29 | ethyl 2-(2-amino-5-(2-(2,...)
Show SMILES CCOC(=O)c1csc(n1)-c1c(N)nn2ccc(nc12)N1CCCC1c1cc(F)ccc1F
Show InChI InChI=1S/C22H20F2N6O2S/c1-2-32-22(31)15-11-33-21(26-15)18-19(25)28-30-9-7-17(27-20(18)30)29-8-3-4-16(29)13-10-12(23)5-6-14(13)24/h5-7,9-11,16H,2-4,8H2,1H3,(H2,25,28)
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
NT-3 growth factor receptor


(Homo sapiens (Human))
BDBM472762
PNG
(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...)
Show SMILES CNC(=O)c1c(N)nn2ccc(nc12)N1C[C@@H](F)C[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C18H17F3N6O/c1-23-18(28)15-16(22)25-27-5-4-14(24-17(15)27)26-8-10(20)7-13(26)11-6-9(19)2-3-12(11)21/h2-6,10,13H,7-8H2,1H3,(H2,22,25)(H,23,28)/t10-,13+/m0/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472740
PNG
(2-amino-5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-...)
Show SMILES CC1(C)OCC(CONC(=O)c2c(N)nn3ccc(nc23)N2CCC[C@@H]2c2cc(F)ccc2F)O1
Show InChI InChI=1S/C23H26F2N6O4/c1-23(2)33-11-14(35-23)12-34-29-22(32)19-20(26)28-31-9-7-18(27-21(19)31)30-8-3-4-17(30)15-10-13(24)5-6-16(15)25/h5-7,9-10,14,17H,3-4,8,11-12H2,1-2H3,(H2,26,28)(H,29,32)/t14?,17-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472753
PNG
((2-(2-amino-5-(2-(2,5-difluorophenyl)pyrrolidin-1-...)
Show SMILES Nc1nn2ccc(nc2c1-c1nc(cs1)C(=O)N1CC[C@H](O)C1)N1CCCC1c1cc(F)ccc1F
Show InChI InChI=1S/C24H23F2N7O2S/c25-13-3-4-16(26)15(10-13)18-2-1-7-32(18)19-6-9-33-22(29-19)20(21(27)30-33)23-28-17(12-36-23)24(35)31-8-5-14(34)11-31/h3-4,6,9-10,12,14,18,34H,1-2,5,7-8,11H2,(H2,27,30)/t14-,18?/m0/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472754
PNG
(2-amino-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)p...)
Show SMILES NC(=S)c1c(N)nn2ccc(nc12)N1CCCC1c1cc(F)ccc1F
Show InChI InChI=1S/C17H16F2N6S/c18-9-3-4-11(19)10(8-9)12-2-1-6-24(12)13-5-7-25-17(22-13)14(16(21)26)15(20)23-25/h3-5,7-8,12H,1-2,6H2,(H2,20,23)(H2,21,26)
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472772
PNG
(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...)
Show SMILES Nc1nn2ccc(nc2c1C(=O)NOCCO)N1C[C@@H](F)C[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C19H19F3N6O3/c20-10-1-2-13(22)12(7-10)14-8-11(21)9-27(14)15-3-4-28-18(24-15)16(17(23)25-28)19(30)26-31-6-5-29/h1-4,7,11,14,29H,5-6,8-9H2,(H2,23,25)(H,26,30)/t11-,14+/m0/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472735
PNG
(2-amino-5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-...)
Show SMILES Nc1nn2ccc(nc2c1C(=O)N[C@H]1CC[C@H](O)CC1)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C23H26F2N6O2/c24-13-3-8-17(25)16(12-13)18-2-1-10-30(18)19-9-11-31-22(28-19)20(21(26)29-31)23(33)27-14-4-6-15(32)7-5-14/h3,8-9,11-12,14-15,18,32H,1-2,4-7,10H2,(H2,26,29)(H,27,33)/t14-,15-,18-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472758
PNG
(US10829492, Example 35 | ethyl 2-amino-5-((2R,4S)-...)
Show SMILES CCOC(=O)c1c(N)nn2ccc(nc12)N1C[C@@H](F)C[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C19H18F3N5O2/c1-2-29-19(28)16-17(23)25-27-6-5-15(24-18(16)27)26-9-11(21)8-14(26)12-7-10(20)3-4-13(12)22/h3-7,11,14H,2,8-9H2,1H3,(H2,23,25)/t11-,14+/m0/s1
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n/an/a<1n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472771
PNG
(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...)
Show SMILES Nc1nn2ccc(nc2c1C(=O)NCCO)N1C[C@@H](F)C[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C19H19F3N6O2/c20-10-1-2-13(22)12(7-10)14-8-11(21)9-27(14)15-3-5-28-18(25-15)16(17(23)26-28)19(30)24-4-6-29/h1-3,5,7,11,14,29H,4,6,8-9H2,(H2,23,26)(H,24,30)/t11-,14+/m0/s1
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n/an/a<1n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))
BDBM472759
PNG
(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...)
Show SMILES NC(=O)c1c(N)nn2ccc(nc12)N1C[C@@H](F)C[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C17H15F3N6O/c18-8-1-2-11(20)10(5-8)12-6-9(19)7-25(12)13-3-4-26-17(23-13)14(16(22)27)15(21)24-26/h1-5,9,12H,6-7H2,(H2,21,24)(H2,22,27)/t9-,12+/m0/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor (TrkA)(G667C)


(Homo sapiens (Human))
BDBM472735
PNG
(2-amino-5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-...)
Show SMILES Nc1nn2ccc(nc2c1C(=O)N[C@H]1CC[C@H](O)CC1)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C23H26F2N6O2/c24-13-3-8-17(25)16(12-13)18-2-1-10-30(18)19-9-11-31-22(28-19)20(21(26)29-31)23(33)27-14-4-6-15(32)7-5-14/h3,8-9,11-12,14-15,18,32H,1-2,4-7,10H2,(H2,26,29)(H,27,33)/t14-,15-,18-/m1/s1
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n/an/a<1n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkAG667C: TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells (purchased from Invitrogen) using pIEX-Bac-4 (purchased from Merck), and purif...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472725
PNG
(2-(2,5-difluorophenyl)-4,4-difluoropyrrolidine | ...)
Show SMILES NC(=O)c1c(N)nn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C17H16F2N6O/c18-9-3-4-11(19)10(8-9)12-2-1-6-24(12)13-5-7-25-17(22-13)14(16(21)26)15(20)23-25/h3-5,7-8,12H,1-2,6H2,(H2,20,23)(H2,21,26)/t12-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
NT-3 growth factor receptor


(Homo sapiens (Human))
BDBM472735
PNG
(2-amino-5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-...)
Show SMILES Nc1nn2ccc(nc2c1C(=O)N[C@H]1CC[C@H](O)CC1)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C23H26F2N6O2/c24-13-3-8-17(25)16(12-13)18-2-1-10-30(18)19-9-11-31-22(28-19)20(21(26)29-31)23(33)27-14-4-6-15(32)7-5-14/h3,8-9,11-12,14-15,18,32H,1-2,4-7,10H2,(H2,26,29)(H,27,33)/t14-,15-,18-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472762
PNG
(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...)
Show SMILES CNC(=O)c1c(N)nn2ccc(nc12)N1C[C@@H](F)C[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C18H17F3N6O/c1-23-18(28)15-16(22)25-27-5-4-14(24-17(15)27)26-8-10(20)7-13(26)11-6-9(19)2-3-12(11)21/h2-6,10,13H,7-8H2,1H3,(H2,22,25)(H,23,28)/t10-,13+/m0/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472707
PNG
((R)-2-amino-5-(2-(2,5-difluorophenyl)pyrrolidin-1-...)
Show SMILES CNC(=O)c1c(N)nn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C18H18F2N6O/c1-22-18(27)15-16(21)24-26-8-6-14(23-17(15)26)25-7-2-3-13(25)11-9-10(19)4-5-12(11)20/h4-6,8-9,13H,2-3,7H2,1H3,(H2,21,24)(H,22,27)/t13-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472726
PNG
(US10829492, Example 5 | ethyl 2-amino-5-(2-(2,5-di...)
Show SMILES CCOC(=O)c1c(N)nn2ccc(nc12)N1CCCC1c1cc(F)ccc1F
Show InChI InChI=1S/C19H19F2N5O2/c1-2-28-19(27)16-17(22)24-26-9-7-15(23-18(16)26)25-8-3-4-14(25)12-10-11(20)5-6-13(12)21/h5-7,9-10,14H,2-4,8H2,1H3,(H2,22,24)
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472734
PNG
((R)-2-amino-5-(2-(2,5-difluorophenyl)pyrrolidin-1-...)
Show SMILES Nc1nn2ccc(nc2c1C(=O)NC1CCC(O)CC1)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C23H26F2N6O2/c24-13-3-8-17(25)16(12-13)18-2-1-10-30(18)19-9-11-31-22(28-19)20(21(26)29-31)23(33)27-14-4-6-15(32)7-5-14/h3,8-9,11-12,14-15,18,32H,1-2,4-7,10H2,(H2,26,29)(H,27,33)/t14?,15?,18-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472759
PNG
(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...)
Show SMILES NC(=O)c1c(N)nn2ccc(nc12)N1C[C@@H](F)C[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C17H15F3N6O/c18-8-1-2-11(20)10(5-8)12-6-9(19)7-25(12)13-3-4-26-17(23-13)14(16(22)27)15(21)24-26/h1-5,9,12H,6-7H2,(H2,21,24)(H2,22,27)/t9-,12+/m0/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472762
PNG
(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...)
Show SMILES CNC(=O)c1c(N)nn2ccc(nc12)N1C[C@@H](F)C[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C18H17F3N6O/c1-23-18(28)15-16(22)25-27-5-4-14(24-17(15)27)26-8-10(20)7-13(26)11-6-9(19)2-3-12(11)21/h2-6,10,13H,7-8H2,1H3,(H2,22,25)(H,23,28)/t10-,13+/m0/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))
BDBM472762
PNG
(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...)
Show SMILES CNC(=O)c1c(N)nn2ccc(nc12)N1C[C@@H](F)C[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C18H17F3N6O/c1-23-18(28)15-16(22)25-27-5-4-14(24-17(15)27)26-8-10(20)7-13(26)11-6-9(19)2-3-12(11)21/h2-6,10,13H,7-8H2,1H3,(H2,22,25)(H,23,28)/t10-,13+/m0/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472705
PNG
(US10829492, Example 1 | ethyl (R)-2-amino-5-(2-(2,...)
Show SMILES CCOC(=O)c1c(N)nn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C19H19F2N5O2/c1-2-28-19(27)16-17(22)24-26-9-7-15(23-18(16)26)25-8-3-4-14(25)12-10-11(20)5-6-13(12)21/h5-7,9-10,14H,2-4,8H2,1H3,(H2,22,24)/t14-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472736
PNG
((R)-2-amino-5-(2-(2,5-difluorophenyl)pyrrolidin-1-...)
Show SMILES Nc1nn2ccc(nc2c1C(=O)NCCO)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C19H20F2N6O2/c20-11-3-4-13(21)12(10-11)14-2-1-7-26(14)15-5-8-27-18(24-15)16(17(22)25-27)19(29)23-6-9-28/h3-5,8,10,14,28H,1-2,6-7,9H2,(H2,22,25)(H,23,29)/t14-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472739
PNG
((R)-2-amino-5-(2-(2,5-difluorophenyl)pyrrolidin-1-...)
Show SMILES CC(C)(CO)ONC(=O)c1c(N)nn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H24F2N6O3/c1-21(2,11-30)32-27-20(31)17-18(24)26-29-9-7-16(25-19(17)29)28-8-3-4-15(28)13-10-12(22)5-6-14(13)23/h5-7,9-10,15,30H,3-4,8,11H2,1-2H3,(H2,24,26)(H,27,31)/t15-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472773
PNG
(2-amino-N-cyclopropyl-5-((2R,4S)-2-(2,5-difluoroph...)
Show SMILES Nc1nn2ccc(nc2c1C(=O)NC1CC1)N1C[C@@H](F)C[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C20H19F3N6O/c21-10-1-4-14(23)13(7-10)15-8-11(22)9-28(15)16-5-6-29-19(26-16)17(18(24)27-29)20(30)25-12-2-3-12/h1,4-7,11-12,15H,2-3,8-9H2,(H2,24,27)(H,25,30)/t11-,15+/m0/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472774
PNG
(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...)
Show SMILES Nc1nn2ccc(nc2c1C(=O)NC1(CO)CC1)N1C[C@@H](F)C[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H21F3N6O2/c22-11-1-2-14(24)13(7-11)15-8-12(23)9-29(15)16-3-6-30-19(26-16)17(18(25)28-30)20(32)27-21(10-31)4-5-21/h1-3,6-7,12,15,31H,4-5,8-10H2,(H2,25,28)(H,27,32)/t12-,15+/m0/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472737
PNG
((R)-2-amino-5-(2-(2,5-difluorophenyl)pyrrolidin-1-...)
Show SMILES Nc1nn2ccc(nc2c1C(=O)Nc1ccc(F)cc1)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C23H19F3N6O/c24-13-3-6-15(7-4-13)28-23(33)20-21(27)30-32-11-9-19(29-22(20)32)31-10-1-2-18(31)16-12-14(25)5-8-17(16)26/h3-9,11-12,18H,1-2,10H2,(H2,27,30)(H,28,33)/t18-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472759
PNG
(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...)
Show SMILES NC(=O)c1c(N)nn2ccc(nc12)N1C[C@@H](F)C[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C17H15F3N6O/c18-8-1-2-11(20)10(5-8)12-6-9(19)7-25(12)13-3-4-26-17(23-13)14(16(22)27)15(21)24-26/h1-5,9,12H,6-7H2,(H2,21,24)(H2,22,27)/t9-,12+/m0/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472735
PNG
(2-amino-5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-...)
Show SMILES Nc1nn2ccc(nc2c1C(=O)N[C@H]1CC[C@H](O)CC1)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C23H26F2N6O2/c24-13-3-8-17(25)16(12-13)18-2-1-10-30(18)19-9-11-31-22(28-19)20(21(26)29-31)23(33)27-14-4-6-15(32)7-5-14/h3,8-9,11-12,14-15,18,32H,1-2,4-7,10H2,(H2,26,29)(H,27,33)/t14-,15-,18-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472742
PNG
((R)-2-amino-5-(2-(2,5-difluorophenyl)pyrrolidin-1-...)
Show SMILES CN(C)CCNC(=O)c1c(N)nn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H25F2N7O/c1-28(2)11-8-25-21(31)18-19(24)27-30-10-7-17(26-20(18)30)29-9-3-4-16(29)14-12-13(22)5-6-15(14)23/h5-7,10,12,16H,3-4,8-9,11H2,1-2H3,(H2,24,27)(H,25,31)/t16-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM472762
PNG
(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...)
Show SMILES CNC(=O)c1c(N)nn2ccc(nc12)N1C[C@@H](F)C[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C18H17F3N6O/c1-23-18(28)15-16(22)25-27-5-4-14(24-17(15)27)26-8-10(20)7-13(26)11-6-9(19)2-3-12(11)21/h2-6,10,13H,7-8H2,1H3,(H2,22,25)(H,23,28)/t10-,13+/m0/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK2: A testing platform for JAK2 kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
NT-3 growth factor receptor


(Homo sapiens (Human))
BDBM472737
PNG
((R)-2-amino-5-(2-(2,5-difluorophenyl)pyrrolidin-1-...)
Show SMILES Nc1nn2ccc(nc2c1C(=O)Nc1ccc(F)cc1)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C23H19F3N6O/c24-13-3-6-15(7-4-13)28-23(33)20-21(27)30-32-11-9-19(29-22(20)32)31-10-1-2-18(31)16-12-14(25)5-8-17(16)26/h3-9,11-12,18H,1-2,10H2,(H2,27,30)(H,28,33)/t18-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
NT-3 growth factor receptor


(Homo sapiens (Human))
BDBM472725
PNG
(2-(2,5-difluorophenyl)-4,4-difluoropyrrolidine | ...)
Show SMILES NC(=O)c1c(N)nn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C17H16F2N6O/c18-9-3-4-11(19)10(8-9)12-2-1-6-24(12)13-5-7-25-17(22-13)14(16(21)26)15(20)23-25/h3-5,7-8,12H,1-2,6H2,(H2,20,23)(H2,21,26)/t12-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))
BDBM472725
PNG
(2-(2,5-difluorophenyl)-4,4-difluoropyrrolidine | ...)
Show SMILES NC(=O)c1c(N)nn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C17H16F2N6O/c18-9-3-4-11(19)10(8-9)12-2-1-6-24(12)13-5-7-25-17(22-13)14(16(21)26)15(20)23-25/h3-5,7-8,12H,1-2,6H2,(H2,20,23)(H2,21,26)/t12-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor (TrkA)(G667C)


(Homo sapiens (Human))
BDBM472762
PNG
(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...)
Show SMILES CNC(=O)c1c(N)nn2ccc(nc12)N1C[C@@H](F)C[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C18H17F3N6O/c1-23-18(28)15-16(22)25-27-5-4-14(24-17(15)27)26-8-10(20)7-13(26)11-6-9(19)2-3-12(11)21/h2-6,10,13H,7-8H2,1H3,(H2,22,25)(H,23,28)/t10-,13+/m0/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkAG667C: TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells (purchased from Invitrogen) using pIEX-Bac-4 (purchased from Merck), and purif...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor (TrkA)(G667C)


(Homo sapiens (Human))
BDBM472759
PNG
(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...)
Show SMILES NC(=O)c1c(N)nn2ccc(nc12)N1C[C@@H](F)C[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C17H15F3N6O/c18-8-1-2-11(20)10(5-8)12-6-9(19)7-25(12)13-3-4-26-17(23-13)14(16(22)27)15(21)24-26/h1-5,9,12H,6-7H2,(H2,21,24)(H2,22,27)/t9-,12+/m0/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkAG667C: TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells (purchased from Invitrogen) using pIEX-Bac-4 (purchased from Merck), and purif...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))
BDBM472737
PNG
((R)-2-amino-5-(2-(2,5-difluorophenyl)pyrrolidin-1-...)
Show SMILES Nc1nn2ccc(nc2c1C(=O)Nc1ccc(F)cc1)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C23H19F3N6O/c24-13-3-6-15(7-4-13)28-23(33)20-21(27)30-32-11-9-19(29-22(20)32)31-10-1-2-18(31)16-12-14(25)5-8-17(16)26/h3-9,11-12,18H,1-2,10H2,(H2,27,30)(H,28,33)/t18-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM472735
PNG
(2-amino-5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-...)
Show SMILES Nc1nn2ccc(nc2c1C(=O)N[C@H]1CC[C@H](O)CC1)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C23H26F2N6O2/c24-13-3-8-17(25)16(12-13)18-2-1-10-30(18)19-9-11-31-22(28-19)20(21(26)29-31)23(33)27-14-4-6-15(32)7-5-14/h3,8-9,11-12,14-15,18,32H,1-2,4-7,10H2,(H2,26,29)(H,27,33)/t14-,15-,18-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK2: A testing platform for JAK2 kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472733
PNG
((2-amino-5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1...)
Show SMILES Nc1nn2ccc(nc2c1C(=O)N1CCC(O)C1)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H22F2N6O2/c22-12-3-4-15(23)14(10-12)16-2-1-7-28(16)17-6-9-29-20(25-17)18(19(24)26-29)21(31)27-8-5-13(30)11-27/h3-4,6,9-10,13,16,30H,1-2,5,7-8,11H2,(H2,24,26)/t13?,16-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472748
PNG
((R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyraz...)
Show SMILES Nc1cc2nc(ccn2n1)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C16H15F2N5/c17-10-3-4-12(18)11(8-10)13-2-1-6-22(13)15-5-7-23-16(20-15)9-14(19)21-23/h3-5,7-9,13H,1-2,6H2,(H2,19,21)/t13-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472761
PNG
(US10829492, Example 38 | ethyl 2-amino-5-(2-(2,5-d...)
Show SMILES CCOC(=O)c1c(N)nn2ccc(nc12)N1CC(F)(F)CC1c1cc(F)ccc1F
Show InChI InChI=1S/C19H17F4N5O2/c1-2-30-18(29)15-16(24)26-28-6-5-14(25-17(15)28)27-9-19(22,23)8-13(27)11-7-10(20)3-4-12(11)21/h3-7,13H,2,8-9H2,1H3,(H2,24,26)
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472766
PNG
(US10829492, Example 43 | ethyl 2-amino-5-(2-(2,5-d...)
Show SMILES CCOC(=O)c1c(N)nn2ccc(nc12)N1CC(=O)CC1c1cc(F)ccc1F
Show InChI InChI=1S/C19H17F2N5O3/c1-2-29-19(28)16-17(22)24-26-6-5-15(23-18(16)26)25-9-11(27)8-14(25)12-7-10(20)3-4-13(12)21/h3-7,14H,2,8-9H2,1H3,(H2,22,24)
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472767
PNG
(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-hydrox...)
Show SMILES Nc1nn2ccc(nc2c1C#N)N1C[C@@H](O)C[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C17H14F2N6O/c18-9-1-2-13(19)11(5-9)14-6-10(26)8-24(14)15-3-4-25-17(22-15)12(7-20)16(21)23-25/h1-5,10,14,26H,6,8H2,(H2,21,23)/t10-,14+/m0/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472768
PNG
(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-hydrox...)
Show SMILES NC(=O)c1c(N)nn2ccc(nc12)N1C[C@@H](O)C[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C17H16F2N6O2/c18-8-1-2-11(19)10(5-8)12-6-9(26)7-24(12)13-3-4-25-17(22-13)14(16(21)27)15(20)23-25/h1-5,9,12,26H,6-7H2,(H2,20,23)(H2,21,27)/t9-,12+/m0/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472732
PNG
(US10829492, Example 9 | ethyl (R)-2-acetylamino-5-...)
Show SMILES CCOC(=O)c1c(NC(C)=O)nn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H21F2N5O3/c1-3-31-21(30)18-19(24-12(2)29)26-28-10-8-17(25-20(18)28)27-9-4-5-16(27)14-11-13(22)6-7-15(14)23/h6-8,10-11,16H,3-5,9H2,1-2H3,(H,24,26,29)/t16-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472750
PNG
(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-(4-met...)
Show SMILES Cc1coc(n1)-c1c(N)nn2ccc(nc12)N1CCCC1c1cc(F)ccc1F
Show InChI InChI=1S/C20H18F2N6O/c1-11-10-29-20(24-11)17-18(23)26-28-8-6-16(25-19(17)28)27-7-2-3-15(27)13-9-12(21)4-5-14(13)22/h4-6,8-10,15H,2-3,7H2,1H3,(H2,23,26)
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472756
PNG
(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-(3-mor...)
Show SMILES Nc1nn2ccc(nc2c1-c1cccc(c1)N1CCOCC1)N1CCCC1c1cc(F)ccc1F
Show InChI InChI=1S/C26H26F2N6O/c27-18-6-7-21(28)20(16-18)22-5-2-9-33(22)23-8-10-34-26(30-23)24(25(29)31-34)17-3-1-4-19(15-17)32-11-13-35-14-12-32/h1,3-4,6-8,10,15-16,22H,2,5,9,11-14H2,(H2,29,31)
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472751
PNG
(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-(4-met...)
Show SMILES Cc1csc(n1)-c1c(N)nn2ccc(nc12)N1CCCC1c1cc(F)ccc1F
Show InChI InChI=1S/C20H18F2N6S/c1-11-10-29-20(24-11)17-18(23)26-28-8-6-16(25-19(17)28)27-7-2-3-15(27)13-9-12(21)4-5-14(13)22/h4-6,8-10,15H,2-3,7H2,1H3,(H2,23,26)
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472765
PNG
(US10829492, Example 42 | ethyl 2-amino-5-((4R)-2-(...)
Show SMILES CCOC(=O)c1c(N)nn2ccc(nc12)N1C[C@H](O)CC1c1cc(F)ccc1F
Show InChI InChI=1S/C19H19F2N5O3/c1-2-29-19(28)16-17(22)24-26-6-5-15(23-18(16)26)25-9-11(27)8-14(25)12-7-10(20)3-4-13(12)21/h3-7,11,14,27H,2,8-9H2,1H3,(H2,22,24)/t11-,14?/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472738
PNG
((R)-2-amino-5-(2-(2,5-difluorophenyl)pyrrolidin-1-...)
Show SMILES CN(C)C(=O)c1c(N)nn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C19H20F2N6O/c1-25(2)19(28)16-17(22)24-27-9-7-15(23-18(16)27)26-8-3-4-14(26)12-10-11(20)5-6-13(12)21/h5-7,9-10,14H,3-4,8H2,1-2H3,(H2,22,24)/t14-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472755
PNG
((R)-3-bromo-5-(2-(2,5-difluorophenyl)pyrrolidin-1-...)
Show SMILES Nc1nn2ccc(nc2c1Br)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C16H14BrF2N5/c17-14-15(20)22-24-7-5-13(21-16(14)24)23-6-1-2-12(23)10-8-9(18)3-4-11(10)19/h3-5,7-8,12H,1-2,6H2,(H2,20,22)/t12-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472745
PNG
(US10829492, Example 22 | ethyl (R)-5-(2-(2,5-diflu...)
Show SMILES CCNc1nn2ccc(nc2c1C(=O)OCC)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H23F2N5O2/c1-3-24-19-18(21(29)30-4-2)20-25-17(9-11-28(20)26-19)27-10-5-6-16(27)14-12-13(22)7-8-15(14)23/h7-9,11-12,16H,3-6,10H2,1-2H3,(H,24,26)/t16-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472731
PNG
(US10829492, Example 7 | ethyl 5-(2-(2,5-difluoroph...)
Show SMILES CCOC(=O)c1c(NC(=O)NC)nn2ccc(nc12)N1CCCC1c1cc(F)ccc1F
Show InChI InChI=1S/C21H22F2N6O3/c1-3-32-20(30)17-18(26-21(31)24-2)27-29-10-8-16(25-19(17)29)28-9-4-5-15(28)13-11-12(22)6-7-14(13)23/h6-8,10-11,15H,3-5,9H2,1-2H3,(H2,24,26,27,31)
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM472759
PNG
(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...)
Show SMILES NC(=O)c1c(N)nn2ccc(nc12)N1C[C@@H](F)C[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C17H15F3N6O/c18-8-1-2-11(20)10(5-8)12-6-9(19)7-25(12)13-3-4-26-17(23-13)14(16(22)27)15(21)24-26/h1-5,9,12H,6-7H2,(H2,21,24)(H2,22,27)/t9-,12+/m0/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK2: A testing platform for JAK2 kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472746
PNG
(US10829492, Example 23 | ethyl (R)-5-(2-(2,5-diflu...)
Show SMILES CCOC(=O)c1c(NCCN2CCOCC2)nn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C25H30F2N6O3/c1-2-36-25(34)22-23(28-8-11-31-12-14-35-15-13-31)30-33-10-7-21(29-24(22)33)32-9-3-4-20(32)18-16-17(26)5-6-19(18)27/h5-7,10,16,20H,2-4,8-9,11-15H2,1H3,(H,28,30)/t20-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472706
PNG
((R)-2-amino-5-(2-(2,5-difluorophenyl)pyrrolidin-1-...)
Show SMILES Nc1nn2ccc(nc2c1C(O)=O)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C17H15F2N5O2/c18-9-3-4-11(19)10(8-9)12-2-1-6-23(12)13-5-7-24-16(21-13)14(17(25)26)15(20)22-24/h3-5,7-8,12H,1-2,6H2,(H2,20,22)(H,25,26)/t12-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472749
PNG
(US10829492, Example 26 | ethyl 2-(5-(2-(2,5-difluo...)
Show SMILES CCOC(=O)c1coc(n1)-c1c(NCc2ccc(OC)cc2)nn2ccc(nc12)N1CCCC1c1cc(F)ccc1F
Show InChI InChI=1S/C30H28F2N6O4/c1-3-41-30(39)23-17-42-29(34-23)26-27(33-16-18-6-9-20(40-2)10-7-18)36-38-14-12-25(35-28(26)38)37-13-4-5-24(37)21-15-19(31)8-11-22(21)32/h6-12,14-15,17,24H,3-5,13,16H2,1-2H3,(H,33,36)
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM472737
PNG
((R)-2-amino-5-(2-(2,5-difluorophenyl)pyrrolidin-1-...)
Show SMILES Nc1nn2ccc(nc2c1C(=O)Nc1ccc(F)cc1)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C23H19F3N6O/c24-13-3-6-15(7-4-13)28-23(33)20-21(27)30-32-11-9-19(29-22(20)32)31-10-1-2-18(31)16-12-14(25)5-8-17(16)26/h3-9,11-12,18H,1-2,10H2,(H2,27,30)(H,28,33)/t18-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK2: A testing platform for JAK2 kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472747
PNG
(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[...)
Show SMILES Nc1cc2nc(ccn2n1)N1CCCC1c1cc(F)ccc1F
Show InChI InChI=1S/C16H15F2N5/c17-10-3-4-12(18)11(8-10)13-2-1-6-22(13)15-5-7-23-16(20-15)9-14(19)21-23/h3-5,7-9,13H,1-2,6H2,(H2,19,21)
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472770
PNG
(US10829492, Example 48 | ethyl 2-amino-5-((4S)-2-(...)
Show SMILES CCOC(=O)c1c(N)nn2ccc(nc12)N1C[C@@H](O)CC1c1cc(F)ccc1F
Show InChI InChI=1S/C19H19F2N5O3/c1-2-29-19(28)16-17(22)24-26-6-5-15(23-18(16)26)25-9-11(27)8-14(25)12-7-10(20)3-4-13(12)21/h3-7,11,14,27H,2,8-9H2,1H3,(H2,22,24)/t11-,14?/m0/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472744
PNG
((R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-2-(m...)
Show SMILES CNc1nn2ccc(nc2c1C(N)=O)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C18H18F2N6O/c1-22-17-15(16(21)27)18-23-14(6-8-26(18)24-17)25-7-2-3-13(25)11-9-10(19)4-5-12(11)20/h4-6,8-9,13H,2-3,7H2,1H3,(H2,21,27)(H,22,24)/t13-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472760
PNG
(US10829492, Example 37 | ethyl 2-amino-5-((2S,4S)-...)
Show SMILES CCOC(=O)c1c(N)nn2ccc(nc12)N1C[C@@H](F)C[C@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C19H18F3N5O2/c1-2-29-19(28)16-17(23)25-27-6-5-15(24-18(16)27)26-9-11(21)8-14(26)12-7-10(20)3-4-13(12)22/h3-7,11,14H,2,8-9H2,1H3,(H2,23,25)/t11-,14-/m0/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472743
PNG
(US10829492, Example 20 | ethyl (R)-5-(2-(2,5-diflu...)
Show SMILES CCOC(=O)c1c(NC)nn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C20H21F2N5O2/c1-3-29-20(28)17-18(23-2)25-27-10-8-16(24-19(17)27)26-9-4-5-15(26)13-11-12(21)6-7-14(13)22/h6-8,10-11,15H,3-5,9H2,1-2H3,(H,23,25)/t15-/m1/s1
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM472769
PNG
(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-hydrox...)
Show SMILES NC(=O)c1c(N)nn2ccc(nc12)N1C[C@@H](O)C[C@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C17H16F2N6O2/c18-8-1-2-11(19)10(5-8)12-6-9(26)7-24(12)13-3-4-25-17(22-13)14(16(21)27)15(20)23-25/h1-5,9,12,26H,6-7H2,(H2,20,23)(H2,21,27)/t9-,12-/m0/s1
PDB
MMDB

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n/an/a<1.00E+3n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM472725
PNG
(2-(2,5-difluorophenyl)-4,4-difluoropyrrolidine | ...)
Show SMILES NC(=O)c1c(N)nn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C17H16F2N6O/c18-9-3-4-11(19)10(8-9)12-2-1-6-24(12)13-5-7-25-17(22-13)14(16(21)26)15(20)23-25/h3-5,7-8,12H,1-2,6H2,(H2,20,23)(H2,21,26)/t12-/m1/s1
PDB

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KEGG

UniProtKB/SwissProt

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antibodypedia
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n/an/a>2.00E+3n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK2: A testing platform for JAK2 kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of...


US Patent US10829492 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%