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Patent code US10829493

Compile Data Set for Download or QSAR
Found 69 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM472775
PNG
(US10829493, Example 1)
Show SMILES CC(C)(O)Cn1cc(cn1)-c1cc2c(N)ncnn2c1
Show InChI InChI=1S/C13H16N6O/c1-13(2,20)7-18-5-10(4-16-18)9-3-11-12(14)15-8-17-19(11)6-9/h3-6,8,20H,7H2,1-2H3,(H2,14,15,17)
PDB

GoogleScholar
UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM472777
PNG
(US10829493, Example 3)
Show SMILES C[C@@H](O)Cn1cc(cn1)-c1cc2c(N)ncnn2c1
Show InChI InChI=1S/C12H14N6O/c1-8(19)4-17-5-10(3-15-17)9-2-11-12(13)14-7-16-18(11)6-9/h2-3,5-8,19H,4H2,1H3,(H2,13,14,16)/t8-/m1/s1
PDB

GoogleScholar
UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM472788
PNG
(US10829493, Example 14)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H]1CCOC1
Show InChI InChI=1S/C29H31FN10O/c1-29(31,22-2-4-24(30)5-3-22)23-14-32-28(33-15-23)38-9-7-37(8-10-38)27-26-12-20(16-40(26)36-19-34-27)21-13-35-39(17-21)25-6-11-41-18-25/h2-5,12-17,19,25H,6-11,18,31H2,1H3/t25-,29+/m1/s1
PDB

GoogleScholar
UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM472783
PNG
(US10829493, Example 9)
Show SMILES C[C@H](O)Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1
Show InChI InChI=1S/C28H31FN10O/c1-19(40)15-38-16-21(12-34-38)20-11-25-26(33-18-35-39(25)17-20)36-7-9-37(10-8-36)27-31-13-23(14-32-27)28(2,30)22-3-5-24(29)6-4-22/h3-6,11-14,16-19,40H,7-10,15,30H2,1-2H3/t19-,28-/m0/s1
PDB

GoogleScholar
UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM472787
PNG
(US10829493, Example 13)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)C1(CO)CC1
Show InChI InChI=1S/C29H31FN10O/c1-28(31,22-2-4-24(30)5-3-22)23-14-32-27(33-15-23)38-10-8-37(9-11-38)26-25-12-20(16-39(25)36-19-34-26)21-13-35-40(17-21)29(18-41)6-7-29/h2-5,12-17,19,41H,6-11,18,31H2,1H3/t28-/m0/s1
PDB

GoogleScholar
UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM472789
PNG
(US10829493, Example 15)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H]1CCOC1
Show InChI InChI=1S/C29H31FN10O/c1-29(31,22-2-4-24(30)5-3-22)23-14-32-28(33-15-23)38-9-7-37(8-10-38)27-26-12-20(16-40(26)36-19-34-27)21-13-35-39(17-21)25-6-11-41-18-25/h2-5,12-17,19,25H,6-11,18,31H2,1H3/t25-,29-/m0/s1
PDB

GoogleScholar
UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM472792
PNG
(US10829493, Example 18)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H]1COC[C@@H]1O
Show InChI InChI=1S/C29H31FN10O2/c1-29(31,21-2-4-23(30)5-3-21)22-12-32-28(33-13-22)38-8-6-37(7-9-38)27-24-10-19(14-39(24)36-18-34-27)20-11-35-40(15-20)25-16-42-17-26(25)41/h2-5,10-15,18,25-26,41H,6-9,16-17,31H2,1H3/t25-,26-,29-/m0/s1
PDB

GoogleScholar
UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM469288
PNG
(US10807985, Compound 63 | US10829493, Example 63 o...)
Show SMILES CCn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1
Show InChI InChI=1S/C27H29FN10/c1-3-37-16-20(13-33-37)19-12-24-25(32-18-34-38(24)17-19)35-8-10-36(11-9-35)26-30-14-22(15-31-26)27(2,29)21-4-6-23(28)7-5-21/h4-7,12-18H,3,8-11,29H2,1-2H3/t27-/m0/s1
PDB

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PC cid
PC sid
UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM472777
PNG
(US10829493, Example 3)
Show SMILES C[C@@H](O)Cn1cc(cn1)-c1cc2c(N)ncnn2c1
Show InChI InChI=1S/C12H14N6O/c1-8(19)4-17-5-10(3-15-17)9-2-11-12(13)14-7-16-18(11)6-9/h2-3,5-8,19H,4H2,1H3,(H2,13,14,16)/t8-/m1/s1
PDB

GoogleScholar
UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM472778
PNG
(US10829493, Example 4)
Show SMILES Nc1ncnn2cc(cc12)-c1cnn(CCO)c1
Show InChI InChI=1S/C11H12N6O/c12-11-10-3-8(6-17(10)15-7-13-11)9-4-14-16(5-9)1-2-18/h3-7,18H,1-2H2,(H2,12,13,15)
PDB

GoogleScholar
UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM472779
PNG
(US10829493, Example 5)
Show SMILES C[C@H](CO)n1cc(cn1)-c1cc2c(N)ncnn2c1
Show InChI InChI=1S/C12H14N6O/c1-8(6-19)17-5-10(3-15-17)9-2-11-12(13)14-7-16-18(11)4-9/h2-5,7-8,19H,6H2,1H3,(H2,13,14,16)/t8-/m1/s1
PDB

GoogleScholar
UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM472781
PNG
(US10829493, Example 7)
Show SMILES Nc1ncnn2cc(cc12)-c1cnn(c1)C1COC1
Show InChI InChI=1S/C12H12N6O/c13-12-11-1-8(3-18(11)16-7-14-12)9-2-15-17(4-9)10-5-19-6-10/h1-4,7,10H,5-6H2,(H2,13,14,16)
PDB

GoogleScholar
UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM472791
PNG
(US10829493, Example 17)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H]1COC[C@@H]1O
Show InChI InChI=1S/C29H31FN10O2/c1-29(31,21-2-4-23(30)5-3-21)22-12-32-28(33-13-22)38-8-6-37(7-9-38)27-24-10-19(14-39(24)36-18-34-27)20-11-35-40(15-20)25-16-42-17-26(25)41/h2-5,10-15,18,25-26,41H,6-9,16-17,31H2,1H3/t25-,26+,29+/m1/s1
PDB

GoogleScholar
UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM472792
PNG
(US10829493, Example 18)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H]1COC[C@@H]1O
Show InChI InChI=1S/C29H31FN10O2/c1-29(31,21-2-4-23(30)5-3-21)22-12-32-28(33-13-22)38-8-6-37(7-9-38)27-24-10-19(14-39(24)36-18-34-27)20-11-35-40(15-20)25-16-42-17-26(25)41/h2-5,10-15,18,25-26,41H,6-9,16-17,31H2,1H3/t25-,26-,29-/m0/s1
PDB

GoogleScholar
UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM472793
PNG
(US10829493, Example 19)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H]1COC[C@H]1O
Show InChI InChI=1S/C29H31FN10O2/c1-29(31,21-2-4-23(30)5-3-21)22-12-32-28(33-13-22)38-8-6-37(7-9-38)27-24-10-19(14-39(24)36-18-34-27)20-11-35-40(15-20)25-16-42-17-26(25)41/h2-5,10-15,18,25-26,41H,6-9,16-17,31H2,1H3/t25-,26-,29+/m1/s1
PDB

GoogleScholar
UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM472796
PNG
(US10829493, Example 22)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H]1CC[C@H]1O
Show InChI InChI=1S/C29H31FN10O/c1-29(31,21-2-4-23(30)5-3-21)22-14-32-28(33-15-22)38-10-8-37(9-11-38)27-25-12-19(16-40(25)36-18-34-27)20-13-35-39(17-20)24-6-7-26(24)41/h2-5,12-18,24,26,41H,6-11,31H2,1H3/t24-,26-,29+/m1/s1
PDB

GoogleScholar
UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM472775
PNG
(US10829493, Example 1)
Show SMILES CC(C)(O)Cn1cc(cn1)-c1cc2c(N)ncnn2c1
Show InChI InChI=1S/C13H16N6O/c1-13(2,20)7-18-5-10(4-16-18)9-3-11-12(14)15-8-17-19(11)6-9/h3-6,8,20H,7H2,1-2H3,(H2,14,15,17)
PDB

GoogleScholar
UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM472779
PNG
(US10829493, Example 5)
Show SMILES C[C@H](CO)n1cc(cn1)-c1cc2c(N)ncnn2c1
Show InChI InChI=1S/C12H14N6O/c1-8(6-19)17-5-10(3-15-17)9-2-11-12(13)14-7-16-18(11)4-9/h2-5,7-8,19H,6H2,1H3,(H2,13,14,16)/t8-/m1/s1
PDB

GoogleScholar
UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM472781
PNG
(US10829493, Example 7)
Show SMILES Nc1ncnn2cc(cc12)-c1cnn(c1)C1COC1
Show InChI InChI=1S/C12H12N6O/c13-12-11-1-8(3-18(11)16-7-14-12)9-2-15-17(4-9)10-5-19-6-10/h1-4,7,10H,5-6H2,(H2,13,14,16)
PDB

GoogleScholar
UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM472786
PNG
(US10829493, Example 12)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(CC2(O)CC2)c1
Show InChI InChI=1S/C29H31FN10O/c1-28(31,22-2-4-24(30)5-3-22)23-14-32-27(33-15-23)38-10-8-37(9-11-38)26-25-12-20(17-40(25)36-19-34-26)21-13-35-39(16-21)18-29(41)6-7-29/h2-5,12-17,19,41H,6-11,18,31H2,1H3/t28-/m0/s1
PDB

GoogleScholar
UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM472786
PNG
(US10829493, Example 12)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(CC2(O)CC2)c1
Show InChI InChI=1S/C29H31FN10O/c1-28(31,22-2-4-24(30)5-3-22)23-14-32-27(33-15-23)38-10-8-37(9-11-38)26-25-12-20(17-40(25)36-19-34-26)21-13-35-39(16-21)18-29(41)6-7-29/h2-5,12-17,19,41H,6-11,18,31H2,1H3/t28-/m0/s1
PDB

GoogleScholar
UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM472788
PNG
(US10829493, Example 14)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H]1CCOC1
Show InChI InChI=1S/C29H31FN10O/c1-29(31,22-2-4-24(30)5-3-22)23-14-32-28(33-15-23)38-9-7-37(8-10-38)27-26-12-20(16-40(26)36-19-34-27)21-13-35-39(17-21)25-6-11-41-18-25/h2-5,12-17,19,25H,6-11,18,31H2,1H3/t25-,29+/m1/s1
PDB

GoogleScholar
UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM472789
PNG
(US10829493, Example 15)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H]1CCOC1
Show InChI InChI=1S/C29H31FN10O/c1-29(31,22-2-4-24(30)5-3-22)23-14-32-28(33-15-23)38-9-7-37(8-10-38)27-26-12-20(16-40(26)36-19-34-27)21-13-35-39(17-21)25-6-11-41-18-25/h2-5,12-17,19,25H,6-11,18,31H2,1H3/t25-,29-/m0/s1
PDB

GoogleScholar
UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM472793
PNG
(US10829493, Example 19)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H]1COC[C@H]1O
Show InChI InChI=1S/C29H31FN10O2/c1-29(31,21-2-4-23(30)5-3-21)22-12-32-28(33-13-22)38-8-6-37(7-9-38)27-24-10-19(14-39(24)36-18-34-27)20-11-35-40(15-20)25-16-42-17-26(25)41/h2-5,10-15,18,25-26,41H,6-9,16-17,31H2,1H3/t25-,26-,29+/m1/s1
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n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM472794
PNG
(US10829493, Example 20)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H]1COC[C@H]1O
Show InChI InChI=1S/C29H31FN10O2/c1-29(31,21-2-4-23(30)5-3-21)22-12-32-28(33-13-22)38-8-6-37(7-9-38)27-24-10-19(14-39(24)36-18-34-27)20-11-35-40(15-20)25-16-42-17-26(25)41/h2-5,10-15,18,25-26,41H,6-9,16-17,31H2,1H3/t25-,26+,29-/m0/s1
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UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM472795
PNG
(US10829493, Example 21)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H]1CC[C@@H]1O
Show InChI InChI=1S/C29H31FN10O/c1-29(31,21-2-4-23(30)5-3-21)22-14-32-28(33-15-22)38-10-8-37(9-11-38)27-25-12-19(16-40(25)36-18-34-27)20-13-35-39(17-20)24-6-7-26(24)41/h2-5,12-18,24,26,41H,6-11,31H2,1H3/t24-,26-,29-/m0/s1
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UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM472784
PNG
(US10829493, Example 10)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)C1C[C@H](O)C1
Show InChI InChI=1S/C29H31FN10O/c1-29(31,21-2-4-23(30)5-3-21)22-14-32-28(33-15-22)38-8-6-37(7-9-38)27-26-10-19(16-40(26)36-18-34-27)20-13-35-39(17-20)24-11-25(41)12-24/h2-5,10,13-18,24-25,41H,6-9,11-12,31H2,1H3/t24?,25-,29-/m0/s1
PDB

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UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM472790
PNG
(US10829493, Example 16)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)C1CCOCC1
Show InChI InChI=1S/C30H33FN10O/c1-30(32,23-2-4-25(31)5-3-23)24-16-33-29(34-17-24)39-10-8-38(9-11-39)28-27-14-21(18-41(27)37-20-35-28)22-15-36-40(19-22)26-6-12-42-13-7-26/h2-5,14-20,26H,6-13,32H2,1H3/t30-/m0/s1
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n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM472796
PNG
(US10829493, Example 22)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H]1CC[C@H]1O
Show InChI InChI=1S/C29H31FN10O/c1-29(31,21-2-4-23(30)5-3-21)22-14-32-28(33-15-22)38-10-8-37(9-11-38)27-25-12-19(16-40(25)36-18-34-27)20-13-35-39(17-20)24-6-7-26(24)41/h2-5,12-18,24,26,41H,6-11,31H2,1H3/t24-,26-,29+/m1/s1
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UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM469288
PNG
(US10807985, Compound 63 | US10829493, Example 63 o...)
Show SMILES CCn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1
Show InChI InChI=1S/C27H29FN10/c1-3-37-16-20(13-33-37)19-12-24-25(32-18-34-38(24)17-19)35-8-10-36(11-9-35)26-30-14-22(15-31-26)27(2,29)21-4-6-23(28)7-5-21/h4-7,12-18H,3,8-11,29H2,1-2H3/t27-/m0/s1
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PC cid
PC sid
UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM472776
PNG
(US10829493, Example 2)
Show SMILES CC(C)(CO)n1cc(cn1)-c1cc2c(N)ncnn2c1
Show InChI InChI=1S/C13H16N6O/c1-13(2,7-20)19-6-10(4-16-19)9-3-11-12(14)15-8-17-18(11)5-9/h3-6,8,20H,7H2,1-2H3,(H2,14,15,17)
PDB

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UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM472780
PNG
(US10829493, Example 6)
Show SMILES C[C@@H](CO)n1cc(cn1)-c1cc2c(N)ncnn2c1
Show InChI InChI=1S/C12H14N6O/c1-8(6-19)17-5-10(3-15-17)9-2-11-12(13)14-7-16-18(11)4-9/h2-5,7-8,19H,6H2,1H3,(H2,13,14,16)/t8-/m0/s1
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UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM472780
PNG
(US10829493, Example 6)
Show SMILES C[C@@H](CO)n1cc(cn1)-c1cc2c(N)ncnn2c1
Show InChI InChI=1S/C12H14N6O/c1-8(6-19)17-5-10(3-15-17)9-2-11-12(13)14-7-16-18(11)4-9/h2-5,7-8,19H,6H2,1H3,(H2,13,14,16)/t8-/m0/s1
PDB

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UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM472782
PNG
(US10829493, Example 8)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(CC2COC2)c1
Show InChI InChI=1S/C29H31FN10O/c1-29(31,23-2-4-25(30)5-3-23)24-12-32-28(33-13-24)38-8-6-37(7-9-38)27-26-10-21(16-40(26)36-19-34-27)22-11-35-39(15-22)14-20-17-41-18-20/h2-5,10-13,15-16,19-20H,6-9,14,17-18,31H2,1H3/t29-/m0/s1
PDB

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UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM472785
PNG
(US10829493, Example 11)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)C1C[C@H](O)C1
Show InChI InChI=1S/C29H31FN10O/c1-29(31,21-2-4-23(30)5-3-21)22-14-32-28(33-15-22)38-8-6-37(7-9-38)27-26-10-19(16-40(26)36-18-34-27)20-13-35-39(17-20)24-11-25(41)12-24/h2-5,10,13-18,24-25,41H,6-9,11-12,31H2,1H3/t24?,25-,29-/m0/s1
PDB

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UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM472794
PNG
(US10829493, Example 20)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H]1COC[C@H]1O
Show InChI InChI=1S/C29H31FN10O2/c1-29(31,21-2-4-23(30)5-3-21)22-12-32-28(33-13-22)38-8-6-37(7-9-38)27-24-10-19(14-39(24)36-18-34-27)20-11-35-40(15-20)25-16-42-17-26(25)41/h2-5,10-15,18,25-26,41H,6-9,16-17,31H2,1H3/t25-,26+,29-/m0/s1
PDB

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UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM472778
PNG
(US10829493, Example 4)
Show SMILES Nc1ncnn2cc(cc12)-c1cnn(CCO)c1
Show InChI InChI=1S/C11H12N6O/c12-11-10-3-8(6-17(10)15-7-13-11)9-4-14-16(5-9)1-2-18/h3-7,18H,1-2H2,(H2,12,13,15)
PDB

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UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM472782
PNG
(US10829493, Example 8)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(CC2COC2)c1
Show InChI InChI=1S/C29H31FN10O/c1-29(31,23-2-4-25(30)5-3-23)24-12-32-28(33-13-24)38-8-6-37(7-9-38)27-26-10-21(16-40(26)36-19-34-27)22-11-35-39(15-22)14-20-17-41-18-20/h2-5,10-13,15-16,19-20H,6-9,14,17-18,31H2,1H3/t29-/m0/s1
PDB

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UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM472790
PNG
(US10829493, Example 16)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)C1CCOCC1
Show InChI InChI=1S/C30H33FN10O/c1-30(32,23-2-4-25(31)5-3-23)24-16-33-29(34-17-24)39-10-8-38(9-11-39)28-27-14-21(18-41(27)37-20-35-28)22-15-36-40(19-22)26-6-12-42-13-7-26/h2-5,14-20,26H,6-13,32H2,1H3/t30-/m0/s1
PDB

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UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM472783
PNG
(US10829493, Example 9)
Show SMILES C[C@H](O)Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1
Show InChI InChI=1S/C28H31FN10O/c1-19(40)15-38-16-21(12-34-38)20-11-25-26(33-18-35-39(25)17-20)36-7-9-37(10-8-36)27-31-13-23(14-32-27)28(2,30)22-3-5-24(29)6-4-22/h3-6,11-14,16-19,40H,7-10,15,30H2,1-2H3/t19-,28-/m0/s1
PDB

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UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM472785
PNG
(US10829493, Example 11)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)C1C[C@H](O)C1
Show InChI InChI=1S/C29H31FN10O/c1-29(31,21-2-4-23(30)5-3-21)22-14-32-28(33-15-22)38-8-6-37(7-9-38)27-26-10-19(16-40(26)36-18-34-27)20-13-35-39(17-20)24-11-25(41)12-24/h2-5,10,13-18,24-25,41H,6-9,11-12,31H2,1H3/t24?,25-,29-/m0/s1
PDB

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UniChem
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM472791
PNG
(US10829493, Example 17)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H]1COC[C@@H]1O
Show InChI InChI=1S/C29H31FN10O2/c1-29(31,21-2-4-23(30)5-3-21)22-12-32-28(33-13-22)38-8-6-37(7-9-38)27-24-10-19(14-39(24)36-18-34-27)20-11-35-40(15-20)25-16-42-17-26(25)41/h2-5,10-15,18,25-26,41H,6-9,16-17,31H2,1H3/t25-,26+,29+/m1/s1
PDB

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UniChem
n/an/a 0.650n/an/an/an/an/an/a


TBA

Assay Description
PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM472787
PNG
(US10829493, Example 13)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)C1(CO)CC1
Show InChI InChI=1S/C29H31FN10O/c1-28(31,22-2-4-24(30)5-3-22)23-14-32-27(33-15-23)38-10-8-37(9-11-38)26-25-12-20(16-39(25)36-19-34-26)21-13-35-40(17-21)29(18-41)6-7-29/h2-5,12-17,19,41H,6-11,18,31H2,1H3/t28-/m0/s1
PDB

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UniChem
n/an/a 0.650n/an/an/an/an/an/a


TBA

Assay Description
PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM472776
PNG
(US10829493, Example 2)
Show SMILES CC(C)(CO)n1cc(cn1)-c1cc2c(N)ncnn2c1
Show InChI InChI=1S/C13H16N6O/c1-13(2,7-20)19-6-10(4-16-19)9-3-11-12(14)15-8-17-18(11)5-9/h3-6,8,20H,7H2,1-2H3,(H2,14,15,17)
PDB

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UniChem
n/an/a 0.650n/an/an/an/an/an/a


TBA

Assay Description
PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM472795
PNG
(US10829493, Example 21)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H]1CC[C@@H]1O
Show InChI InChI=1S/C29H31FN10O/c1-29(31,21-2-4-23(30)5-3-21)22-14-32-28(33-15-22)38-10-8-37(9-11-38)27-25-12-19(16-40(25)36-18-34-27)20-13-35-39(17-20)24-6-7-26(24)41/h2-5,12-18,24,26,41H,6-11,31H2,1H3/t24-,26-,29-/m0/s1
PDB

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UniChem
n/an/a 0.650n/an/an/an/an/an/a


TBA

Assay Description
PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM472784
PNG
(US10829493, Example 10)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)C1C[C@H](O)C1
Show InChI InChI=1S/C29H31FN10O/c1-29(31,21-2-4-23(30)5-3-21)22-14-32-28(33-15-22)38-8-6-37(7-9-38)27-26-10-19(16-40(26)36-18-34-27)20-13-35-39(17-20)24-11-25(41)12-24/h2-5,10,13-18,24-25,41H,6-9,11-12,31H2,1H3/t24?,25-,29-/m0/s1
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TBA

Assay Description
PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...


Citation and Details
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM472777
PNG
(US10829493, Example 3)
Show SMILES C[C@@H](O)Cn1cc(cn1)-c1cc2c(N)ncnn2c1
Show InChI InChI=1S/C12H14N6O/c1-8(19)4-17-5-10(3-15-17)9-2-11-12(13)14-7-16-18(11)6-9/h2-3,5-8,19H,4H2,1H3,(H2,13,14,16)/t8-/m1/s1
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TBA

Assay Description
Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...


Citation and Details
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM472795
PNG
(US10829493, Example 21)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H]1CC[C@@H]1O
Show InChI InChI=1S/C29H31FN10O/c1-29(31,21-2-4-23(30)5-3-21)22-14-32-28(33-15-22)38-10-8-37(9-11-38)27-25-12-19(16-40(25)36-18-34-27)20-13-35-39(17-20)24-6-7-26(24)41/h2-5,12-18,24,26,41H,6-11,31H2,1H3/t24-,26-,29-/m0/s1
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TBA

Assay Description
Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...


Citation and Details
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM472788
PNG
(US10829493, Example 14)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H]1CCOC1
Show InChI InChI=1S/C29H31FN10O/c1-29(31,22-2-4-24(30)5-3-22)23-14-32-28(33-15-23)38-9-7-37(8-10-38)27-26-12-20(16-40(26)36-19-34-27)21-13-35-39(17-21)25-6-11-41-18-25/h2-5,12-17,19,25H,6-11,18,31H2,1H3/t25-,29+/m1/s1
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TBA

Assay Description
Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...


Citation and Details
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM472794
PNG
(US10829493, Example 20)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H]1COC[C@H]1O
Show InChI InChI=1S/C29H31FN10O2/c1-29(31,21-2-4-23(30)5-3-21)22-12-32-28(33-13-22)38-8-6-37(7-9-38)27-24-10-19(14-39(24)36-18-34-27)20-11-35-40(15-20)25-16-42-17-26(25)41/h2-5,10-15,18,25-26,41H,6-9,16-17,31H2,1H3/t25-,26+,29-/m0/s1
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TBA

Assay Description
Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...


Citation and Details
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM472780
PNG
(US10829493, Example 6)
Show SMILES C[C@@H](CO)n1cc(cn1)-c1cc2c(N)ncnn2c1
Show InChI InChI=1S/C12H14N6O/c1-8(6-19)17-5-10(3-15-17)9-2-11-12(13)14-7-16-18(11)4-9/h2-5,7-8,19H,6H2,1H3,(H2,13,14,16)/t8-/m0/s1
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TBA

Assay Description
Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...


Citation and Details
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM472790
PNG
(US10829493, Example 16)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)C1CCOCC1
Show InChI InChI=1S/C30H33FN10O/c1-30(32,23-2-4-25(31)5-3-23)24-16-33-29(34-17-24)39-10-8-38(9-11-39)28-27-14-21(18-41(27)37-20-35-28)22-15-36-40(19-22)26-6-12-42-13-7-26/h2-5,14-20,26H,6-13,32H2,1H3/t30-/m0/s1
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TBA

Assay Description
Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...


Citation and Details
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM472796
PNG
(US10829493, Example 22)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H]1CC[C@H]1O
Show InChI InChI=1S/C29H31FN10O/c1-29(31,21-2-4-23(30)5-3-21)22-14-32-28(33-15-22)38-10-8-37(9-11-38)27-25-12-19(16-40(25)36-18-34-27)20-13-35-39(17-20)24-6-7-26(24)41/h2-5,12-18,24,26,41H,6-11,31H2,1H3/t24-,26-,29+/m1/s1
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TBA

Assay Description
Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...


Citation and Details
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM472775
PNG
(US10829493, Example 1)
Show SMILES CC(C)(O)Cn1cc(cn1)-c1cc2c(N)ncnn2c1
Show InChI InChI=1S/C13H16N6O/c1-13(2,20)7-18-5-10(4-16-18)9-3-11-12(14)15-8-17-19(11)6-9/h3-6,8,20H,7H2,1-2H3,(H2,14,15,17)
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TBA

Assay Description
Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...


Citation and Details
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM472779
PNG
(US10829493, Example 5)
Show SMILES C[C@H](CO)n1cc(cn1)-c1cc2c(N)ncnn2c1
Show InChI InChI=1S/C12H14N6O/c1-8(6-19)17-5-10(3-15-17)9-2-11-12(13)14-7-16-18(11)4-9/h2-5,7-8,19H,6H2,1H3,(H2,13,14,16)/t8-/m1/s1
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TBA

Assay Description
Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...


Citation and Details
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM472781
PNG
(US10829493, Example 7)
Show SMILES Nc1ncnn2cc(cc12)-c1cnn(c1)C1COC1
Show InChI InChI=1S/C12H12N6O/c13-12-11-1-8(3-18(11)16-7-14-12)9-2-15-17(4-9)10-5-19-6-10/h1-4,7,10H,5-6H2,(H2,13,14,16)
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TBA

Assay Description
Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...


Citation and Details
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM472786
PNG
(US10829493, Example 12)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(CC2(O)CC2)c1
Show InChI InChI=1S/C29H31FN10O/c1-28(31,22-2-4-24(30)5-3-22)23-14-32-27(33-15-23)38-10-8-37(9-11-38)26-25-12-20(17-40(25)36-19-34-26)21-13-35-39(16-21)18-29(41)6-7-29/h2-5,12-17,19,41H,6-11,18,31H2,1H3/t28-/m0/s1
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TBA

Assay Description
Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...


Citation and Details
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM472789
PNG
(US10829493, Example 15)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H]1CCOC1
Show InChI InChI=1S/C29H31FN10O/c1-29(31,22-2-4-24(30)5-3-22)23-14-32-28(33-15-23)38-9-7-37(8-10-38)27-26-12-20(16-40(26)36-19-34-27)21-13-35-39(17-21)25-6-11-41-18-25/h2-5,12-17,19,25H,6-11,18,31H2,1H3/t25-,29-/m0/s1
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TBA

Assay Description
Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...


Citation and Details
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM472792
PNG
(US10829493, Example 18)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H]1COC[C@@H]1O
Show InChI InChI=1S/C29H31FN10O2/c1-29(31,21-2-4-23(30)5-3-21)22-12-32-28(33-13-22)38-8-6-37(7-9-38)27-24-10-19(14-39(24)36-18-34-27)20-11-35-40(15-20)25-16-42-17-26(25)41/h2-5,10-15,18,25-26,41H,6-9,16-17,31H2,1H3/t25-,26-,29-/m0/s1
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TBA

Assay Description
Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...


Citation and Details
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM472782
PNG
(US10829493, Example 8)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(CC2COC2)c1
Show InChI InChI=1S/C29H31FN10O/c1-29(31,23-2-4-25(30)5-3-23)24-12-32-28(33-13-24)38-8-6-37(7-9-38)27-26-10-21(16-40(26)36-19-34-27)22-11-35-39(15-22)14-20-17-41-18-20/h2-5,10-13,15-16,19-20H,6-9,14,17-18,31H2,1H3/t29-/m0/s1
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TBA

Assay Description
Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...


Citation and Details
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM472784
PNG
(US10829493, Example 10)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)C1C[C@H](O)C1
Show InChI InChI=1S/C29H31FN10O/c1-29(31,21-2-4-23(30)5-3-21)22-14-32-28(33-15-22)38-8-6-37(7-9-38)27-26-10-19(16-40(26)36-18-34-27)20-13-35-39(17-20)24-11-25(41)12-24/h2-5,10,13-18,24-25,41H,6-9,11-12,31H2,1H3/t24?,25-,29-/m0/s1
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TBA

Assay Description
Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...


Citation and Details
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM469288
PNG
(US10807985, Compound 63 | US10829493, Example 63 o...)
Show SMILES CCn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1
Show InChI InChI=1S/C27H29FN10/c1-3-37-16-20(13-33-37)19-12-24-25(32-18-34-38(24)17-19)35-8-10-36(11-9-35)26-30-14-22(15-31-26)27(2,29)21-4-6-23(28)7-5-21/h4-7,12-18H,3,8-11,29H2,1-2H3/t27-/m0/s1
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n/an/an/a 17.5n/an/an/an/an/a


TBA

Assay Description
Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...


Citation and Details
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM472776
PNG
(US10829493, Example 2)
Show SMILES CC(C)(CO)n1cc(cn1)-c1cc2c(N)ncnn2c1
Show InChI InChI=1S/C13H16N6O/c1-13(2,7-20)19-6-10(4-16-19)9-3-11-12(14)15-8-17-18(11)5-9/h3-6,8,20H,7H2,1-2H3,(H2,14,15,17)
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TBA

Assay Description
Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...


Citation and Details
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM472791
PNG
(US10829493, Example 17)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H]1COC[C@@H]1O
Show InChI InChI=1S/C29H31FN10O2/c1-29(31,21-2-4-23(30)5-3-21)22-12-32-28(33-13-22)38-8-6-37(7-9-38)27-24-10-19(14-39(24)36-18-34-27)20-11-35-40(15-20)25-16-42-17-26(25)41/h2-5,10-15,18,25-26,41H,6-9,16-17,31H2,1H3/t25-,26+,29+/m1/s1
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TBA

Assay Description
Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...


Citation and Details
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM472787
PNG
(US10829493, Example 13)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)C1(CO)CC1
Show InChI InChI=1S/C29H31FN10O/c1-28(31,22-2-4-24(30)5-3-22)23-14-32-27(33-15-23)38-10-8-37(9-11-38)26-25-12-20(16-39(25)36-19-34-26)21-13-35-40(17-21)29(18-41)6-7-29/h2-5,12-17,19,41H,6-11,18,31H2,1H3/t28-/m0/s1
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TBA

Assay Description
Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...


Citation and Details
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM472783
PNG
(US10829493, Example 9)
Show SMILES C[C@H](O)Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1
Show InChI InChI=1S/C28H31FN10O/c1-19(40)15-38-16-21(12-34-38)20-11-25-26(33-18-35-39(25)17-20)36-7-9-37(10-8-36)27-31-13-23(14-32-27)28(2,30)22-3-5-24(29)6-4-22/h3-6,11-14,16-19,40H,7-10,15,30H2,1-2H3/t19-,28-/m0/s1
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TBA

Assay Description
Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...


Citation and Details
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM472778
PNG
(US10829493, Example 4)
Show SMILES Nc1ncnn2cc(cc12)-c1cnn(CCO)c1
Show InChI InChI=1S/C11H12N6O/c12-11-10-3-8(6-17(10)15-7-13-11)9-4-14-16(5-9)1-2-18/h3-7,18H,1-2H2,(H2,12,13,15)
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TBA

Assay Description
Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...


Citation and Details
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM472793
PNG
(US10829493, Example 19)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H]1COC[C@H]1O
Show InChI InChI=1S/C29H31FN10O2/c1-29(31,21-2-4-23(30)5-3-21)22-12-32-28(33-13-22)38-8-6-37(7-9-38)27-24-10-19(14-39(24)36-18-34-27)20-11-35-40(15-20)25-16-42-17-26(25)41/h2-5,10-15,18,25-26,41H,6-9,16-17,31H2,1H3/t25-,26-,29+/m1/s1
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n/an/an/a<10n/an/an/an/an/a


TBA

Assay Description
Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...


Citation and Details
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM472785
PNG
(US10829493, Example 11)
Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)C1C[C@H](O)C1
Show InChI InChI=1S/C29H31FN10O/c1-29(31,21-2-4-23(30)5-3-21)22-14-32-28(33-15-22)38-8-6-37(7-9-38)27-26-10-19(16-40(26)36-18-34-27)20-13-35-39(17-20)24-11-25(41)12-24/h2-5,10,13-18,24-25,41H,6-9,11-12,31H2,1H3/t24?,25-,29-/m0/s1
PDB

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UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
n/an/an/a<10n/an/an/an/an/a


TBA

Assay Description
Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%